example/loop_annotation/loop_annotation.ipynb

{
 "cells": [
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "# Loop Annotation"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Input files"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "Polaris requires a `.mcool` file as input. You can obtain `.mcool` files in the following ways:"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### 1. Download from the 4DN Database\n",
    "\n",
    "- Visit the [4DN Data Portal](https://data.4dnucleome.org/).\n",
    "- Search for and download `.mcool` files suitable for your study."
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### 2. Convert Files Using cooler\n",
    "\n",
    "If you have data in formats such as `.pairs` or `.cool`, you can convert them to `.mcool` format using the Python library [cooler](https://cooler.readthedocs.io/en/latest/index.html). Follow these steps:\n",
    "\n",
    "- **Install cooler**\n",
    "\n",
    "  Ensure you have installed cooler using the following command:\n",
    "  ```bash\n",
    "  pip install cooler\n",
    "  ```\n",
    "- **Convert .pairs to .cool**\n",
    "\n",
    "   If you are starting with a .pairs file (e.g., normalized contact data with columns for chrom1, pos1, chrom2, pos2), use this command to create a .cool file:\n",
    "   ```bash\n",
    "   cooler cload pairs --assembly <genome_version> -c1 chrom1 -p1 pos1 -c2 chrom2 -p2 pos2 <pairs_file> <resolution>.cool\n",
    "   ```\n",
    "   Replace `<genome_version> with the appropriate genome assembly (e.g., hg38) and <resolution> with the desired bin size in base pairs.\n",
    "- **Generate a Multiresolution .mcool File**\n",
    "\n",
    "   To convert a single-resolution .cool file into a multiresolution .mcool file, use the following command:\n",
    "\n",
    "   ```bash\n",
    "   cooler zoomify <input.cool>\n",
    "   ```"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "The resulting `.mcool` file can be directly used as input for Polaris."
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Loop Annotation by Polaris"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Download example data\n",
    "\n",
    "You can download example data from the [Hugging Face repo of Polaris](https://huggingface.co/rr-ss/Polaris/resolve/main/example/loop_annotation/GM12878_250M.bcool?download=true) by runing:"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "--2025-03-10 16:52:13--  https://huggingface.co/rr-ss/Polaris/resolve/main/example/loop_annotation/GM12878_250M.bcool?download=true\n",
      "Resolving huggingface.co (huggingface.co)... 54.230.71.103, 54.230.71.28, 54.230.71.2, ...\n",
      "Connecting to huggingface.co (huggingface.co)|54.230.71.103|:443... connected.\n",
      "HTTP request sent, awaiting response... 302 Found\n",
      "Location: https://cdn-lfs-us-1.hf.co/repos/23/0c/230c589108031ad469781dc63a8df8d4f9950d91b268b326f2a95c3481e4100c/962c8dbb130eb024d9d931cf50ace2f1adff8a84bdbf023f6d3770d27842212d?response-content-disposition=attachment%3B+filename*%3DUTF-8%27%27GM12878_250M.bcool%3B+filename%3D%22GM12878_250M.bcool%22%3B&Expires=1741600333&Policy=eyJTdGF0ZW1lbnQiOlt7IkNvbmRpdGlvbiI6eyJEYXRlTGVzc1RoYW4iOnsiQVdTOkVwb2NoVGltZSI6MTc0MTYwMDMzM319LCJSZXNvdXJjZSI6Imh0dHBzOi8vY2RuLWxmcy11cy0xLmhmLmNvL3JlcG9zLzIzLzBjLzIzMGM1ODkxMDgwMzFhZDQ2OTc4MWRjNjNhOGRmOGQ0Zjk5NTBkOTFiMjY4YjMyNmYyYTk1YzM0ODFlNDEwMGMvOTYyYzhkYmIxMzBlYjAyNGQ5ZDkzMWNmNTBhY2UyZjFhZGZmOGE4NGJkYmYwMjNmNmQzNzcwZDI3ODQyMjEyZD9yZXNwb25zZS1jb250ZW50LWRpc3Bvc2l0aW9uPSoifV19&Signature=u4wqE3K8b7QrOnuHC0dU45iNb-fEpLC0PrKoTVcCFyRTBC71rXSrGz%7EL5BD-uhWhMEOLbo%7EzBroiIYryDu%7E3yZwflYXsWmgXJ29uwDtdMyY5cZ3tr51F53CUEo2gtnFBL6rJF6-UZ5ipMURVV0yfvTq9HkCQrJL-5HkoNbkMt7gdQ2bft36CuA-HXPsG8vAX5Bs97SwXogzkYjKG5hVQq0h%7EnowuBrrpX4aXmoncVkf47QojJ3lgwMwSTqIDdpGiTzUBDfA03kSDTkAWdO7zO7WHJo3yAQlIsKLdIl4uawCl0xKWDcadB5Ck-qPJYJI28UnOvnMW39G9qQQ4lJoV4w__&Key-Pair-Id=K24J24Z295AEI9 [following]\n",
      "--2025-03-10 16:52:13--  https://cdn-lfs-us-1.hf.co/repos/23/0c/230c589108031ad469781dc63a8df8d4f9950d91b268b326f2a95c3481e4100c/962c8dbb130eb024d9d931cf50ace2f1adff8a84bdbf023f6d3770d27842212d?response-content-disposition=attachment%3B+filename*%3DUTF-8%27%27GM12878_250M.bcool%3B+filename%3D%22GM12878_250M.bcool%22%3B&Expires=1741600333&Policy=eyJTdGF0ZW1lbnQiOlt7IkNvbmRpdGlvbiI6eyJEYXRlTGVzc1RoYW4iOnsiQVdTOkVwb2NoVGltZSI6MTc0MTYwMDMzM319LCJSZXNvdXJjZSI6Imh0dHBzOi8vY2RuLWxmcy11cy0xLmhmLmNvL3JlcG9zLzIzLzBjLzIzMGM1ODkxMDgwMzFhZDQ2OTc4MWRjNjNhOGRmOGQ0Zjk5NTBkOTFiMjY4YjMyNmYyYTk1YzM0ODFlNDEwMGMvOTYyYzhkYmIxMzBlYjAyNGQ5ZDkzMWNmNTBhY2UyZjFhZGZmOGE4NGJkYmYwMjNmNmQzNzcwZDI3ODQyMjEyZD9yZXNwb25zZS1jb250ZW50LWRpc3Bvc2l0aW9uPSoifV19&Signature=u4wqE3K8b7QrOnuHC0dU45iNb-fEpLC0PrKoTVcCFyRTBC71rXSrGz%7EL5BD-uhWhMEOLbo%7EzBroiIYryDu%7E3yZwflYXsWmgXJ29uwDtdMyY5cZ3tr51F53CUEo2gtnFBL6rJF6-UZ5ipMURVV0yfvTq9HkCQrJL-5HkoNbkMt7gdQ2bft36CuA-HXPsG8vAX5Bs97SwXogzkYjKG5hVQq0h%7EnowuBrrpX4aXmoncVkf47QojJ3lgwMwSTqIDdpGiTzUBDfA03kSDTkAWdO7zO7WHJo3yAQlIsKLdIl4uawCl0xKWDcadB5Ck-qPJYJI28UnOvnMW39G9qQQ4lJoV4w__&Key-Pair-Id=K24J24Z295AEI9\n",
      "Resolving cdn-lfs-us-1.hf.co (cdn-lfs-us-1.hf.co)... 3.171.198.15, 3.171.198.97, 3.171.198.59, ...\n",
      "Connecting to cdn-lfs-us-1.hf.co (cdn-lfs-us-1.hf.co)|3.171.198.15|:443... connected.\n",
      "HTTP request sent, awaiting response... 200 OK\n",
      "Length: 70088396 (67M) [binary/octet-stream]\n",
      "Saving to: ‘./GM12878_250M.bcool’\n",
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      "  7550K .......... .......... .......... .......... .......... 11% 16.6M 12s\n",
      "  7600K .......... .......... .......... .......... .......... 11% 18.8M 12s\n",
      "  7650K .......... .......... .......... .......... .......... 11% 17.6M 12s\n",
      "  7700K .......... .......... .......... .......... .......... 11% 12.8M 12s\n",
      "  7750K .......... .......... .......... .......... .......... 11% 23.0M 12s\n",
      "  7800K .......... .......... .......... .......... .......... 11% 20.8M 12s\n",
      "  7850K .......... .......... .......... .......... .......... 11% 15.9M 12s\n",
      "  7900K .......... .......... .......... .......... .......... 11% 14.1M 12s\n",
      "  7950K .......... .......... .......... .......... .......... 11% 24.5M 12s\n",
      "  8000K .......... .......... .......... .......... .......... 11% 15.2M 11s\n",
      "  8050K .......... .......... .......... .......... .......... 11% 24.0M 11s\n",
      "  8100K .......... .......... .......... .......... .......... 11% 19.9M 11s\n",
      "  8150K .......... .......... .......... .......... .......... 11% 23.5M 11s\n",
      "  8200K .......... .......... .......... .......... .......... 12% 15.7M 11s\n",
      "  8250K .......... .......... .......... .......... .......... 12% 12.3M 11s\n",
      "  8300K .......... .......... .......... .......... .......... 12% 20.3M 11s\n",
      "  8350K .......... .......... .......... .......... .......... 12% 29.3M 11s\n",
      "  8400K .......... .......... .......... .......... .......... 12% 24.8M 11s\n",
      "  8450K .......... .......... .......... .......... .......... 12% 15.8M 11s\n",
      "  8500K .......... .......... .......... .......... .......... 12% 16.3M 11s\n",
      "  8550K .......... .......... .......... .......... .......... 12% 64.5M 11s\n",
      "  8600K .......... .......... .......... .......... .......... 12% 16.7M 11s\n",
      "  8650K .......... .......... .......... .......... .......... 12% 22.7M 11s\n",
      "  8700K .......... .......... .......... .......... .......... 12% 16.1M 11s\n",
      "  8750K .......... .......... .......... .......... .......... 12% 18.7M 11s\n",
      "  8800K .......... .......... .......... .......... .......... 12% 56.7M 11s\n",
      "  8850K .......... .......... .......... .......... .......... 13% 16.1M 11s\n",
      "  8900K .......... .......... .......... .......... .......... 13% 26.9M 10s\n",
      "  8950K .......... .......... .......... .......... .......... 13% 16.3M 10s\n",
      "  9000K .......... .......... .......... .......... .......... 13% 19.6M 10s\n",
      "  9050K .......... .......... .......... .......... .......... 13% 19.1M 10s\n",
      "  9100K .......... .......... .......... .......... .......... 13% 18.1M 10s\n",
      "  9150K .......... .......... .......... .......... .......... 13% 10.3M 10s\n",
      "  9200K .......... .......... .......... .......... .......... 13% 25.3M 10s\n",
      "  9250K .......... .......... .......... .......... .......... 13% 10.5M 10s\n",
      "  9300K .......... .......... .......... .......... .......... 13% 11.7M 10s\n",
      "  9350K .......... .......... .......... .......... .......... 13% 11.3M 10s\n",
      "  9400K .......... .......... .......... .......... .......... 13% 9.83M 10s\n",
      "  9450K .......... .......... .......... .......... .......... 13% 24.7M 10s\n",
      "  9500K .......... .......... .......... .......... .......... 13% 10.1M 10s\n",
      "  9550K .......... .......... .......... .......... .......... 14% 17.3M 10s\n",
      "  9600K .......... .......... .......... .......... .......... 14% 10.8M 10s\n",
      "  9650K .......... .......... .......... .......... .......... 14% 24.5M 10s\n",
      "  9700K .......... .......... .......... .......... .......... 14% 12.2M 10s\n",
      "  9750K .......... .......... .......... .......... .......... 14% 10.4M 10s\n",
      "  9800K .......... .......... .......... .......... .......... 14% 14.9M 10s\n",
      "  9850K .......... .......... .......... .......... .......... 14% 14.1M 10s\n",
      "  9900K .......... .......... .......... .......... .......... 14% 24.0M 10s\n",
      "  9950K .......... .......... .......... .......... .......... 14% 10.9M 10s\n",
      " 10000K .......... .......... .......... .......... .......... 14% 13.6M 10s\n",
      " 10050K .......... .......... .......... .......... .......... 14% 18.2M 10s\n",
      " 10100K .......... .......... .......... .......... .......... 14% 11.4M 10s\n",
      " 10150K .......... .......... .......... .......... .......... 14% 13.9M 9s\n",
      " 10200K .......... .......... .......... .......... .......... 14% 24.5M 9s\n",
      " 10250K .......... .......... .......... .......... .......... 15% 12.6M 9s\n",
      " 10300K .......... .......... .......... .......... .......... 15% 24.8M 9s\n",
      " 10350K .......... .......... .......... .......... .......... 15% 11.7M 9s\n",
      " 10400K .......... .......... .......... .......... .......... 15% 27.5M 9s\n",
      " 10450K .......... .......... .......... .......... .......... 15% 14.8M 9s\n",
      " 10500K .......... .......... .......... .......... .......... 15% 11.7M 9s\n",
      " 10550K .......... .......... .......... .......... .......... 15% 34.5M 9s\n",
      " 10600K .......... .......... .......... .......... .......... 15% 15.9M 9s\n",
      " 10650K .......... .......... .......... .......... .......... 15% 12.6M 9s\n",
      " 10700K .......... .......... .......... .......... .......... 15% 30.0M 9s\n",
      " 10750K .......... .......... .......... .......... .......... 15% 13.7M 9s\n",
      " 10800K .......... .......... .......... .......... .......... 15% 21.2M 9s\n",
      " 10850K .......... .......... .......... .......... .......... 15% 31.9M 9s\n",
      " 10900K .......... .......... .......... .......... .......... 15% 12.6M 9s\n",
      " 10950K .......... .......... .......... .......... .......... 16% 14.6M 9s\n",
      " 11000K .......... .......... .......... .......... .......... 16% 25.7M 9s\n",
      " 11050K .......... .......... .......... .......... .......... 16% 14.7M 9s\n",
      " 11100K .......... .......... .......... .......... .......... 16% 15.2M 9s\n",
      " 11150K .......... .......... .......... .......... .......... 16% 15.0M 9s\n",
      " 11200K .......... .......... .......... .......... .......... 16% 15.7M 9s\n",
      " 11250K .......... .......... .......... .......... .......... 16% 12.5M 9s\n",
      " 11300K .......... .......... .......... .......... .......... 16%  129M 9s\n",
      " 11350K .......... .......... .......... .......... .......... 16% 19.4M 9s\n",
      " 11400K .......... .......... .......... .......... .......... 16% 15.0M 9s\n",
      " 11450K .......... .......... .......... .......... .......... 16% 15.9M 9s\n",
      " 11500K .......... .......... .......... .......... .......... 16% 16.3M 9s\n",
      " 11550K .......... .......... .......... .......... .......... 16%  122M 9s\n",
      " 11600K .......... .......... .......... .......... .......... 17% 16.2M 8s\n",
      " 11650K .......... .......... .......... .......... .......... 17% 20.9M 8s\n",
      " 11700K .......... .......... .......... .......... .......... 17% 16.3M 8s\n",
      " 11750K .......... .......... .......... .......... .......... 17% 17.6M 8s\n",
      " 11800K .......... .......... .......... .......... .......... 17% 88.1M 8s\n",
      " 11850K .......... .......... .......... .......... .......... 17% 82.2M 8s\n",
      " 11900K .......... .......... .......... .......... .......... 17% 16.9M 8s\n",
      " 11950K .......... .......... .......... .......... .......... 17% 22.4M 8s\n",
      " 12000K .......... .......... .......... .......... .......... 17% 20.2M 8s\n",
      " 12050K .......... .......... .......... .......... .......... 17% 37.3M 8s\n",
      " 12100K .......... .......... .......... .......... .......... 17% 22.3M 8s\n",
      " 12150K .......... .......... .......... .......... .......... 17% 10.8M 8s\n",
      " 12200K .......... .......... .......... .......... .......... 17% 10.6M 8s\n",
      " 12250K .......... .......... .......... .......... .......... 17% 10.5M 8s\n",
      " 12300K .......... .......... .......... .......... .......... 18% 24.8M 8s\n",
      " 12350K .......... .......... .......... .......... .......... 18% 12.0M 8s\n",
      " 12400K .......... .......... .......... .......... .......... 18% 11.5M 8s\n",
      " 12450K .......... .......... .......... .......... .......... 18% 9.64M 8s\n",
      " 12500K .......... .......... .......... .......... .......... 18% 25.8M 8s\n",
      " 12550K .......... .......... .......... .......... .......... 18% 10.0M 8s\n",
      " 12600K .......... .......... .......... .......... .......... 18% 11.1M 8s\n",
      " 12650K .......... .......... .......... .......... .......... 18% 15.6M 8s\n",
      " 12700K .......... .......... .......... .......... .......... 18% 11.8M 8s\n",
      " 12750K .......... .......... .......... .......... .......... 18% 25.0M 8s\n",
      " 12800K .......... .......... .......... .......... .......... 18% 10.8M 8s\n",
      " 12850K .......... .......... .......... .......... .......... 18% 9.96M 8s\n",
      " 12900K .......... .......... .......... .......... .......... 18% 24.7M 8s\n",
      " 12950K .......... .......... .......... .......... .......... 18% 11.1M 8s\n",
      " 13000K .......... .......... .......... .......... .......... 19% 14.0M 8s\n",
      " 13050K .......... .......... .......... .......... .......... 19% 23.7M 8s\n",
      " 13100K .......... .......... .......... .......... .......... 19% 11.7M 8s\n",
      " 13150K .......... .......... .......... .......... .......... 19% 16.2M 8s\n",
      " 13200K .......... .......... .......... .......... .......... 19% 14.1M 8s\n",
      " 13250K .......... .......... .......... .......... .......... 19% 32.2M 8s\n",
      " 13300K .......... .......... .......... .......... .......... 19% 12.1M 8s\n",
      " 13350K .......... .......... .......... .......... .......... 19% 13.4M 8s\n",
      " 13400K .......... .......... .......... .......... .......... 19% 17.2M 8s\n",
      " 13450K .......... .......... .......... .......... .......... 19% 17.7M 8s\n",
      " 13500K .......... .......... .......... .......... .......... 19% 22.5M 8s\n",
      " 13550K .......... .......... .......... .......... .......... 19% 16.9M 8s\n",
      " 13600K .......... .......... .......... .......... .......... 19% 17.2M 7s\n",
      " 13650K .......... .......... .......... .......... .......... 20% 16.9M 7s\n",
      " 13700K .......... .......... .......... .......... .......... 20% 12.4M 7s\n",
      " 13750K .......... .......... .......... .......... .......... 20% 13.3M 7s\n",
      " 13800K .......... .......... .......... .......... .......... 20% 33.4M 7s\n",
      " 13850K .......... .......... .......... .......... .......... 20% 13.6M 7s\n",
      " 13900K .......... .......... .......... .......... .......... 20% 18.1M 7s\n",
      " 13950K .......... .......... .......... .......... .......... 20% 16.5M 7s\n",
      " 14000K .......... .......... .......... .......... .......... 20% 26.6M 7s\n",
      " 14050K .......... .......... .......... .......... .......... 20% 23.5M 7s\n",
      " 14100K .......... .......... .......... .......... .......... 20% 14.8M 7s\n",
      " 14150K .......... .......... .......... .......... .......... 20% 16.0M 7s\n",
      " 14200K .......... .......... .......... .......... .......... 20% 13.5M 7s\n",
      " 14250K .......... .......... .......... .......... .......... 20% 18.2M 7s\n",
      " 14300K .......... .......... .......... .......... .......... 20% 53.4M 7s\n",
      " 14350K .......... .......... .......... .......... .......... 21% 12.8M 7s\n",
      " 14400K .......... .......... .......... .......... .......... 21% 20.9M 7s\n",
      " 14450K .......... .......... .......... .......... .......... 21% 14.1M 7s\n",
      " 14500K .......... .......... .......... .......... .......... 21% 18.6M 7s\n",
      " 14550K .......... .......... .......... .......... .......... 21% 16.0M 7s\n",
      " 14600K .......... .......... .......... .......... .......... 21% 68.2M 7s\n",
      " 14650K .......... .......... .......... .......... .......... 21% 16.1M 7s\n",
      " 14700K .......... .......... .......... .......... .......... 21% 20.3M 7s\n",
      " 14750K .......... .......... .......... .......... .......... 21% 19.0M 7s\n",
      " 14800K .......... .......... .......... .......... .......... 21% 60.3M 7s\n",
      " 14850K .......... .......... .......... .......... .......... 21% 17.8M 7s\n",
      " 14900K .......... .......... .......... .......... .......... 21% 21.1M 7s\n",
      " 14950K .......... .......... .......... .......... .......... 21% 19.9M 7s\n",
      " 15000K .......... .......... .......... .......... .......... 21% 65.3M 7s\n",
      " 15050K .......... .......... .......... .......... .......... 22% 18.1M 7s\n",
      " 15100K .......... .......... .......... .......... .......... 22% 20.3M 7s\n",
      " 15150K .......... .......... .......... .......... .......... 22% 19.8M 7s\n",
      " 15200K .......... .......... .......... .......... .......... 22% 10.7M 7s\n",
      " 15250K .......... .......... .......... .......... .......... 22% 17.4M 7s\n",
      " 15300K .......... .......... .......... .......... .......... 22% 23.9M 7s\n",
      " 15350K .......... .......... .......... .......... .......... 22% 7.33M 7s\n",
      " 15400K .......... .......... .......... .......... .......... 22% 22.6M 7s\n",
      " 15450K .......... .......... .......... .......... .......... 22% 7.98M 7s\n",
      " 15500K .......... .......... .......... .......... .......... 22% 15.5M 7s\n",
      " 15550K .......... .......... .......... .......... .......... 22% 15.9M 7s\n",
      " 15600K .......... .......... .......... .......... .......... 22% 24.0M 7s\n",
      " 15650K .......... .......... .......... .......... .......... 22% 8.07M 7s\n",
      " 15700K .......... .......... .......... .......... .......... 23% 16.0M 7s\n",
      " 15750K .......... .......... .......... .......... .......... 23% 11.5M 7s\n",
      " 15800K .......... .......... .......... .......... .......... 23% 10.1M 7s\n",
      " 15850K .......... .......... .......... .......... .......... 23% 28.7M 7s\n",
      " 15900K .......... .......... .......... .......... .......... 23% 10.3M 7s\n",
      " 15950K .......... .......... .......... .......... .......... 23% 13.1M 7s\n",
      " 16000K .......... .......... .......... .......... .......... 23% 18.0M 7s\n",
      " 16050K .......... .......... .......... .......... .......... 23% 23.4M 7s\n",
      " 16100K .......... .......... .......... .......... .......... 23% 14.0M 7s\n",
      " 16150K .......... .......... .......... .......... .......... 23% 11.7M 7s\n",
      " 16200K .......... .......... .......... .......... .......... 23% 17.0M 6s\n",
      " 16250K .......... .......... .......... .......... .......... 23% 13.8M 6s\n",
      " 16300K .......... .......... .......... .......... .......... 23% 90.7M 6s\n",
      " 16350K .......... .......... .......... .......... .......... 23% 9.40M 6s\n",
      " 16400K .......... .......... .......... .......... .......... 24% 14.8M 6s\n",
      " 16450K .......... .......... .......... .......... .......... 24% 24.0M 6s\n",
      " 16500K .......... .......... .......... .......... .......... 24% 13.0M 6s\n",
      " 16550K .......... .......... .......... .......... .......... 24% 13.7M 6s\n",
      " 16600K .......... .......... .......... .......... .......... 24% 30.3M 6s\n",
      " 16650K .......... .......... .......... .......... .......... 24% 12.9M 6s\n",
      " 16700K .......... .......... .......... .......... .......... 24% 14.1M 6s\n",
      " 16750K .......... .......... .......... .......... .......... 24% 21.3M 6s\n",
      " 16800K .......... .......... .......... .......... .......... 24% 14.0M 6s\n",
      " 16850K .......... .......... .......... .......... .......... 24% 27.4M 6s\n",
      " 16900K .......... .......... .......... .......... .......... 24% 13.9M 6s\n",
      " 16950K .......... .......... .......... .......... .......... 24% 12.6M 6s\n",
      " 17000K .......... .......... .......... .......... .......... 24% 28.9M 6s\n",
      " 17050K .......... .......... .......... .......... .......... 24% 23.7M 6s\n",
      " 17100K .......... .......... .......... .......... .......... 25% 14.3M 6s\n",
      " 17150K .......... .......... .......... .......... .......... 25% 14.3M 6s\n",
      " 17200K .......... .......... .......... .......... .......... 25% 38.4M 6s\n",
      " 17250K .......... .......... .......... .......... .......... 25% 13.8M 6s\n",
      " 17300K .......... .......... .......... .......... .......... 25% 15.5M 6s\n",
      " 17350K .......... .......... .......... .......... .......... 25% 12.5M 6s\n",
      " 17400K .......... .......... .......... .......... .......... 25% 20.7M 6s\n",
      " 17450K .......... .......... .......... .......... .......... 25% 14.4M 6s\n",
      " 17500K .......... .......... .......... .......... .......... 25% 80.7M 6s\n",
      " 17550K .......... .......... .......... .......... .......... 25% 17.1M 6s\n",
      " 17600K .......... .......... .......... .......... .......... 25% 16.0M 6s\n",
      " 17650K .......... .......... .......... .......... .......... 25% 16.0M 6s\n",
      " 17700K .......... .......... .......... .......... .......... 25% 84.1M 6s\n",
      " 17750K .......... .......... .......... .......... .......... 26% 22.4M 6s\n",
      " 17800K .......... .......... .......... .......... .......... 26% 16.9M 6s\n",
      " 17850K .......... .......... .......... .......... .......... 26% 17.0M 6s\n",
      " 17900K .......... .......... .......... .......... .......... 26% 57.2M 6s\n",
      " 17950K .......... .......... .......... .......... .......... 26% 17.8M 6s\n",
      " 18000K .......... .......... .......... .......... .......... 26% 29.1M 6s\n",
      " 18050K .......... .......... .......... .......... .......... 26% 64.7M 6s\n",
      " 18100K .......... .......... .......... .......... .......... 26% 14.6M 6s\n",
      " 18150K .......... .......... .......... .......... .......... 26% 21.0M 6s\n",
      " 18200K .......... .......... .......... .......... .......... 26% 25.2M 6s\n",
      " 18250K .......... .......... .......... .......... .......... 26% 10.9M 6s\n",
      " 18300K .......... .......... .......... .......... .......... 26% 15.9M 6s\n",
      " 18350K .......... .......... .......... .......... .......... 26% 10.4M 6s\n",
      " 18400K .......... .......... .......... .......... .......... 26% 12.3M 6s\n",
      " 18450K .......... .......... .......... .......... .......... 27% 24.5M 6s\n",
      " 18500K .......... .......... .......... .......... .......... 27% 7.94M 6s\n",
      " 18550K .......... .......... .......... .......... .......... 27% 15.3M 6s\n",
      " 18600K .......... .......... .......... .......... .......... 27% 16.5M 6s\n",
      " 18650K .......... .......... .......... .......... .......... 27% 13.5M 6s\n",
      " 18700K .......... .......... .......... .......... .......... 27% 6.62M 6s\n",
      " 18750K .......... .......... .......... .......... .......... 27% 27.1M 6s\n",
      " 18800K .......... .......... .......... .......... .......... 27% 18.2M 6s\n",
      " 18850K .......... .......... .......... .......... .......... 27% 10.2M 6s\n",
      " 18900K .......... .......... .......... .......... .......... 27% 14.7M 6s\n",
      " 18950K .......... .......... .......... .......... .......... 27% 9.92M 6s\n",
      " 19000K .......... .......... .......... .......... .......... 27% 26.9M 6s\n",
      " 19050K .......... .......... .......... .......... .......... 27% 18.0M 6s\n",
      " 19100K .......... .......... .......... .......... .......... 27% 11.8M 6s\n",
      " 19150K .......... .......... .......... .......... .......... 28% 17.5M 6s\n",
      " 19200K .......... .......... .......... .......... .......... 28% 14.8M 6s\n",
      " 19250K .......... .......... .......... .......... .......... 28% 17.4M 6s\n",
      " 19300K .......... .......... .......... .......... .......... 28% 17.5M 6s\n",
      " 19350K .......... .......... .......... .......... .......... 28% 13.4M 6s\n",
      " 19400K .......... .......... .......... .......... .......... 28% 17.9M 6s\n",
      " 19450K .......... .......... .......... .......... .......... 28% 16.3M 6s\n",
      " 19500K .......... .......... .......... .......... .......... 28% 14.9M 6s\n",
      " 19550K .......... .......... .......... .......... .......... 28% 17.3M 6s\n",
      " 19600K .......... .......... .......... .......... .......... 28% 14.7M 6s\n",
      " 19650K .......... .......... .......... .......... .......... 28% 19.3M 6s\n",
      " 19700K .......... .......... .......... .......... .......... 28% 16.5M 6s\n",
      " 19750K .......... .......... .......... .......... .......... 28% 13.3M 5s\n",
      " 19800K .......... .......... .......... .......... .......... 29% 17.5M 5s\n",
      " 19850K .......... .......... .......... .......... .......... 29% 16.9M 5s\n",
      " 19900K .......... .......... .......... .......... .......... 29% 15.5M 5s\n",
      " 19950K .......... .......... .......... .......... .......... 29% 17.6M 5s\n",
      " 20000K .......... .......... .......... .......... .......... 29% 16.2M 5s\n",
      " 20050K .......... .......... .......... .......... .......... 29% 14.9M 5s\n",
      " 20100K .......... .......... .......... .......... .......... 29% 17.3M 5s\n",
      " 20150K .......... .......... .......... .......... .......... 29% 16.8M 5s\n",
      " 20200K .......... .......... .......... .......... .......... 29% 17.6M 5s\n",
      " 20250K .......... .......... .......... .......... .......... 29% 17.4M 5s\n",
      " 20300K .......... .......... .......... .......... .......... 29% 13.3M 5s\n",
      " 20350K .......... .......... .......... .......... .......... 29% 17.4M 5s\n",
      " 20400K .......... .......... .......... .......... .......... 29% 18.0M 5s\n",
      " 20450K .......... .......... .......... .......... .......... 29% 17.6M 5s\n",
      " 20500K .......... .......... .......... .......... .......... 30% 17.1M 5s\n",
      " 20550K .......... .......... .......... .......... .......... 30% 17.6M 5s\n",
      " 20600K .......... .......... .......... .......... .......... 30% 18.0M 5s\n",
      " 20650K .......... .......... .......... .......... .......... 30% 17.5M 5s\n",
      " 20700K .......... .......... .......... .......... .......... 30% 13.3M 5s\n",
      " 20750K .......... .......... .......... .......... .......... 30% 17.4M 5s\n",
      " 20800K .......... .......... .......... .......... .......... 30% 13.9M 5s\n",
      " 20850K .......... .......... .......... .......... .......... 30% 17.6M 5s\n",
      " 20900K .......... .......... .......... .......... .......... 30% 16.6M 5s\n",
      " 20950K .......... .......... .......... .......... .......... 30% 17.6M 5s\n",
      " 21000K .......... .......... .......... .......... .......... 30% 17.5M 5s\n",
      " 21050K .......... .......... .......... .......... .......... 30% 17.5M 5s\n",
      " 21100K .......... .......... .......... .......... .......... 30% 13.3M 5s\n",
      " 21150K .......... .......... .......... .......... .......... 30% 18.1M 5s\n",
      " 21200K .......... .......... .......... .......... .......... 31% 17.5M 5s\n",
      " 21250K .......... .......... .......... .......... .......... 31% 17.4M 5s\n",
      " 21300K .......... .......... .......... .......... .......... 31% 17.1M 5s\n",
      " 21350K .......... .......... .......... .......... .......... 31% 18.1M 5s\n",
      " 21400K .......... .......... .......... .......... .......... 31% 17.5M 5s\n",
      " 21450K .......... .......... .......... .......... .......... 31% 17.5M 5s\n",
      " 21500K .......... .......... .......... .......... .......... 31% 13.3M 5s\n",
      " 21550K .......... .......... .......... .......... .......... 31% 14.0M 5s\n",
      " 21600K .......... .......... .......... .......... .......... 31% 17.5M 5s\n",
      " 21650K .......... .......... .......... .......... .......... 31% 16.7M 5s\n",
      " 21700K .......... .......... .......... .......... .......... 31% 17.2M 5s\n",
      " 21750K .......... .......... .......... .......... .......... 31% 17.5M 5s\n",
      " 21800K .......... .......... .......... .......... .......... 31% 17.6M 5s\n",
      " 21850K .......... .......... .......... .......... .......... 31% 17.8M 5s\n",
      " 21900K .......... .......... .......... .......... .......... 32% 13.4M 5s\n",
      " 21950K .......... .......... .......... .......... .......... 32% 17.5M 5s\n",
      " 22000K .......... .......... .......... .......... .......... 32% 17.5M 5s\n",
      " 22050K .......... .......... .......... .......... .......... 32% 17.5M 5s\n",
      " 22100K .......... .......... .......... .......... .......... 32% 11.1M 5s\n",
      " 22150K .......... .......... .......... .......... .......... 32% 21.6M 5s\n",
      " 22200K .......... .......... .......... .......... .......... 32% 17.4M 5s\n",
      " 22250K .......... .......... .......... .......... .......... 32% 15.1M 5s\n",
      " 22300K .......... .......... .......... .......... .......... 32% 17.3M 5s\n",
      " 22350K .......... .......... .......... .......... .......... 32% 18.1M 5s\n",
      " 22400K .......... .......... .......... .......... .......... 32% 17.5M 5s\n",
      " 22450K .......... .......... .......... .......... .......... 32% 17.3M 5s\n",
      " 22500K .......... .......... .......... .......... .......... 32% 12.6M 5s\n",
      " 22550K .......... .......... .......... .......... .......... 33% 18.7M 5s\n",
      " 22600K .......... .......... .......... .......... .......... 33% 15.1M 5s\n",
      " 22650K .......... .......... .......... .......... .......... 33% 15.7M 5s\n",
      " 22700K .......... .......... .......... .......... .......... 33% 16.2M 5s\n",
      " 22750K .......... .......... .......... .......... .......... 33% 16.6M 5s\n",
      " 22800K .......... .......... .......... .......... .......... 33% 17.4M 5s\n",
      " 22850K .......... .......... .......... .......... .......... 33% 18.1M 5s\n",
      " 22900K .......... .......... .......... .......... .......... 33% 11.4M 5s\n",
      " 22950K .......... .......... .......... .......... .......... 33% 17.4M 5s\n",
      " 23000K .......... .......... .......... .......... .......... 33% 17.6M 5s\n",
      " 23050K .......... .......... .......... .......... .......... 33% 16.7M 5s\n",
      " 23100K .......... .......... .......... .......... .......... 33% 18.6M 5s\n",
      " 23150K .......... .......... .......... .......... .......... 33% 17.4M 5s\n",
      " 23200K .......... .......... .......... .......... .......... 33% 17.4M 5s\n",
      " 23250K .......... .......... .......... .......... .......... 34% 17.5M 5s\n",
      " 23300K .......... .......... .......... .......... .......... 34% 13.4M 5s\n",
      " 23350K .......... .......... .......... .......... .......... 34% 16.8M 5s\n",
      " 23400K .......... .......... .......... .......... .......... 34% 14.7M 5s\n",
      " 23450K .......... .......... .......... .......... .......... 34% 16.3M 5s\n",
      " 23500K .......... .......... .......... .......... .......... 34% 17.4M 5s\n",
      " 23550K .......... .......... .......... .......... .......... 34% 17.3M 5s\n",
      " 23600K .......... .......... .......... .......... .......... 34% 18.1M 5s\n",
      " 23650K .......... .......... .......... .......... .......... 34% 17.5M 5s\n",
      " 23700K .......... .......... .......... .......... .......... 34% 13.3M 5s\n",
      " 23750K .......... .......... .......... .......... .......... 34% 17.5M 5s\n",
      " 23800K .......... .......... .......... .......... .......... 34% 17.5M 5s\n",
      " 23850K .......... .......... .......... .......... .......... 34% 17.9M 5s\n",
      " 23900K .......... .......... .......... .......... .......... 34% 17.3M 5s\n",
      " 23950K .......... .......... .......... .......... .......... 35% 17.2M 5s\n",
      " 24000K .......... .......... .......... .......... .......... 35% 17.6M 5s\n",
      " 24050K .......... .......... .......... .......... .......... 35% 18.0M 5s\n",
      " 24100K .......... .......... .......... .......... .......... 35% 12.8M 5s\n",
      " 24150K .......... .......... .......... .......... .......... 35% 14.7M 5s\n",
      " 24200K .......... .......... .......... .......... .......... 35% 16.3M 5s\n",
      " 24250K .......... .......... .......... .......... .......... 35% 17.5M 5s\n",
      " 24300K .......... .......... .......... .......... .......... 35% 17.3M 5s\n",
      " 24350K .......... .......... .......... .......... .......... 35% 17.9M 5s\n",
      " 24400K .......... .......... .......... .......... .......... 35% 17.5M 5s\n",
      " 24450K .......... .......... .......... .......... .......... 35% 17.5M 5s\n",
      " 24500K .......... .......... .......... .......... .......... 35% 13.3M 5s\n",
      " 24550K .......... .......... .......... .......... .......... 35% 17.4M 4s\n",
      " 24600K .......... .......... .......... .......... .......... 36% 18.0M 4s\n",
      " 24650K .......... .......... .......... .......... .......... 36% 17.5M 4s\n",
      " 24700K .......... .......... .......... .......... .......... 36% 17.3M 4s\n",
      " 24750K .......... .......... .......... .......... .......... 36% 17.4M 4s\n",
      " 24800K .......... .......... .......... .......... .......... 36% 17.9M 4s\n",
      " 24850K .......... .......... .......... .......... .......... 36% 17.5M 4s\n",
      " 24900K .......... .......... .......... .......... .......... 36% 11.2M 4s\n",
      " 24950K .......... .......... .......... .......... .......... 36% 16.3M 4s\n",
      " 25000K .......... .......... .......... .......... .......... 36% 17.5M 4s\n",
      " 25050K .......... .......... .......... .......... .......... 36% 17.4M 4s\n",
      " 25100K .......... .......... .......... .......... .......... 36% 17.9M 4s\n",
      " 25150K .......... .......... .......... .......... .......... 36% 17.4M 4s\n",
      " 25200K .......... .......... .......... .......... .......... 36% 14.4M 4s\n",
      " 25250K .......... .......... .......... .......... .......... 36% 20.6M 4s\n",
      " 25300K .......... .......... .......... .......... .......... 37% 12.0M 4s\n",
      " 25350K .......... .......... .......... .......... .......... 37% 18.2M 4s\n",
      " 25400K .......... .......... .......... .......... .......... 37% 17.4M 4s\n",
      " 25450K .......... .......... .......... .......... .......... 37% 17.4M 4s\n",
      " 25500K .......... .......... .......... .......... .......... 37% 17.3M 4s\n",
      " 25550K .......... .......... .......... .......... .......... 37% 17.4M 4s\n",
      " 25600K .......... .......... .......... .......... .......... 37% 17.4M 4s\n",
      " 25650K .......... .......... .......... .......... .......... 37% 12.4M 4s\n",
      " 25700K .......... .......... .......... .......... .......... 37% 13.0M 4s\n",
      " 25750K .......... .......... .......... .......... .......... 37% 19.2M 4s\n",
      " 25800K .......... .......... .......... .......... .......... 37% 16.0M 4s\n",
      " 25850K .......... .......... .......... .......... .......... 37% 17.9M 4s\n",
      " 25900K .......... .......... .......... .......... .......... 37% 17.4M 4s\n",
      " 25950K .......... .......... .......... .......... .......... 37% 12.2M 4s\n",
      " 26000K .......... .......... .......... .......... .......... 38% 22.5M 4s\n",
      " 26050K .......... .......... .......... .......... .......... 38% 18.6M 4s\n",
      " 26100K .......... .......... .......... .......... .......... 38% 12.7M 4s\n",
      " 26150K .......... .......... .......... .......... .......... 38% 18.8M 4s\n",
      " 26200K .......... .......... .......... .......... .......... 38% 17.6M 4s\n",
      " 26250K .......... .......... .......... .......... .......... 38% 17.5M 4s\n",
      " 26300K .......... .......... .......... .......... .......... 38% 17.5M 4s\n",
      " 26350K .......... .......... .......... .......... .......... 38% 17.5M 4s\n",
      " 26400K .......... .......... .......... .......... .......... 38% 14.0M 4s\n",
      " 26450K .......... .......... .......... .......... .......... 38% 17.4M 4s\n",
      " 26500K .......... .......... .......... .......... .......... 38% 12.7M 4s\n",
      " 26550K .......... .......... .......... .......... .......... 38% 17.4M 4s\n",
      " 26600K .......... .......... .......... .......... .......... 38% 18.1M 4s\n",
      " 26650K .......... .......... .......... .......... .......... 39% 17.6M 4s\n",
      " 26700K .......... .......... .......... .......... .......... 39% 17.3M 4s\n",
      " 26750K .......... .......... .......... .......... .......... 39% 17.4M 4s\n",
      " 26800K .......... .......... .......... .......... .......... 39% 17.9M 4s\n",
      " 26850K .......... .......... .......... .......... .......... 39% 17.6M 4s\n",
      " 26900K .......... .......... .......... .......... .......... 39% 13.3M 4s\n",
      " 26950K .......... .......... .......... .......... .......... 39% 17.2M 4s\n",
      " 27000K .......... .......... .......... .......... .......... 39% 17.5M 4s\n",
      " 27050K .......... .......... .......... .......... .......... 39% 18.1M 4s\n",
      " 27100K .......... .......... .......... .......... .......... 39% 16.9M 4s\n",
      " 27150K .......... .......... .......... .......... .......... 39% 14.3M 4s\n",
      " 27200K .......... .......... .......... .......... .......... 39% 16.6M 4s\n",
      " 27250K .......... .......... .......... .......... .......... 39% 17.0M 4s\n",
      " 27300K .......... .......... .......... .......... .......... 39% 13.4M 4s\n",
      " 27350K .......... .......... .......... .......... .......... 40% 18.0M 4s\n",
      " 27400K .......... .......... .......... .......... .......... 40% 17.5M 4s\n",
      " 27450K .......... .......... .......... .......... .......... 40% 17.3M 4s\n",
      " 27500K .......... .......... .......... .......... .......... 40% 17.5M 4s\n",
      " 27550K .......... .......... .......... .......... .......... 40% 17.8M 4s\n",
      " 27600K .......... .......... .......... .......... .......... 40% 17.6M 4s\n",
      " 27650K .......... .......... .......... .......... .......... 40% 17.4M 4s\n",
      " 27700K .......... .......... .......... .......... .......... 40% 13.4M 4s\n",
      " 27750K .......... .......... .......... .......... .......... 40% 17.5M 4s\n",
      " 27800K .......... .......... .......... .......... .......... 40% 17.8M 4s\n",
      " 27850K .......... .......... .......... .......... .......... 40% 17.6M 4s\n",
      " 27900K .......... .......... .......... .......... .......... 40% 13.8M 4s\n",
      " 27950K .......... .......... .......... .......... .......... 40% 17.5M 4s\n",
      " 28000K .......... .......... .......... .......... .......... 40% 16.4M 4s\n",
      " 28050K .......... .......... .......... .......... .......... 41% 18.0M 4s\n",
      " 28100K .......... .......... .......... .......... .......... 41% 13.2M 4s\n",
      " 28150K .......... .......... .......... .......... .......... 41% 17.6M 4s\n",
      " 28200K .......... .......... .......... .......... .......... 41% 17.5M 4s\n",
      " 28250K .......... .......... .......... .......... .......... 41% 14.4M 4s\n",
      " 28300K .......... .......... .......... .......... .......... 41% 20.4M 4s\n",
      " 28350K .......... .......... .......... .......... .......... 41% 13.3M 4s\n",
      " 28400K .......... .......... .......... .......... .......... 41% 20.8M 4s\n",
      " 28450K .......... .......... .......... .......... .......... 41% 17.5M 4s\n",
      " 28500K .......... .......... .......... .......... .......... 41% 13.2M 4s\n",
      " 28550K .......... .......... .......... .......... .......... 41% 18.0M 4s\n",
      " 28600K .......... .......... .......... .......... .......... 41% 17.3M 4s\n",
      " 28650K .......... .......... .......... .......... .......... 41% 14.0M 4s\n",
      " 28700K .......... .......... .......... .......... .......... 42% 15.0M 4s\n",
      " 28750K .......... .......... .......... .......... .......... 42% 18.2M 4s\n",
      " 28800K .......... .......... .......... .......... .......... 42% 18.6M 4s\n",
      " 28850K .......... .......... .......... .......... .......... 42% 15.7M 4s\n",
      " 28900K .......... .......... .......... .......... .......... 42% 13.3M 4s\n",
      " 28950K .......... .......... .......... .......... .......... 42% 17.6M 4s\n",
      " 29000K .......... .......... .......... .......... .......... 42% 12.3M 4s\n",
      " 29050K .......... .......... .......... .......... .......... 42% 21.5M 4s\n",
      " 29100K .......... .......... .......... .......... .......... 42% 17.3M 4s\n",
      " 29150K .......... .......... .......... .......... .......... 42% 17.4M 4s\n",
      " 29200K .......... .......... .......... .......... .......... 42% 17.4M 4s\n",
      " 29250K .......... .......... .......... .......... .......... 42% 18.1M 4s\n",
      " 29300K .......... .......... .......... .......... .......... 42% 12.7M 4s\n",
      " 29350K .......... .......... .......... .......... .......... 42% 18.6M 4s\n",
      " 29400K .......... .......... .......... .......... .......... 43% 13.9M 4s\n",
      " 29450K .......... .......... .......... .......... .......... 43% 17.5M 4s\n",
      " 29500K .......... .......... .......... .......... .......... 43% 16.2M 4s\n",
      " 29550K .......... .......... .......... .......... .......... 43% 18.0M 4s\n",
      " 29600K .......... .......... .......... .......... .......... 43% 17.4M 4s\n",
      " 29650K .......... .......... .......... .......... .......... 43% 17.2M 4s\n",
      " 29700K .......... .......... .......... .......... .......... 43% 13.5M 4s\n",
      " 29750K .......... .......... .......... .......... .......... 43% 17.2M 4s\n",
      " 29800K .......... .......... .......... .......... .......... 43% 18.3M 4s\n",
      " 29850K .......... .......... .......... .......... .......... 43% 17.4M 4s\n",
      " 29900K .......... .......... .......... .......... .......... 43% 17.4M 4s\n",
      " 29950K .......... .......... .......... .......... .......... 43% 17.5M 4s\n",
      " 30000K .......... .......... .......... .......... .......... 43% 17.9M 4s\n",
      " 30050K .......... .......... .......... .......... .......... 43% 17.5M 4s\n",
      " 30100K .......... .......... .......... .......... .......... 44% 13.3M 4s\n",
      " 30150K .......... .......... .......... .......... .......... 44% 14.0M 4s\n",
      " 30200K .......... .......... .......... .......... .......... 44% 17.4M 4s\n",
      " 30250K .......... .......... .......... .......... .......... 44% 16.3M 4s\n",
      " 30300K .......... .......... .......... .......... .......... 44% 17.9M 4s\n",
      " 30350K .......... .......... .......... .......... .......... 44% 17.4M 4s\n",
      " 30400K .......... .......... .......... .......... .......... 44% 17.2M 4s\n",
      " 30450K .......... .......... .......... .......... .......... 44% 17.8M 4s\n",
      " 30500K .......... .......... .......... .......... .......... 44% 13.3M 4s\n",
      " 30550K .......... .......... .......... .......... .......... 44% 18.0M 4s\n",
      " 30600K .......... .......... .......... .......... .......... 44% 17.5M 4s\n",
      " 30650K .......... .......... .......... .......... .......... 44% 17.5M 4s\n",
      " 30700K .......... .......... .......... .......... .......... 44% 17.3M 4s\n",
      " 30750K .......... .......... .......... .......... .......... 44% 17.9M 4s\n",
      " 30800K .......... .......... .......... .......... .......... 45% 17.5M 4s\n",
      " 30850K .......... .......... .......... .......... .......... 45% 17.4M 4s\n",
      " 30900K .......... .......... .......... .......... .......... 45% 11.2M 4s\n",
      " 30950K .......... .......... .......... .......... .......... 45% 17.5M 4s\n",
      " 31000K .......... .......... .......... .......... .......... 45% 16.3M 3s\n",
      " 31050K .......... .......... .......... .......... .......... 45% 17.9M 3s\n",
      " 31100K .......... .......... .......... .......... .......... 45% 17.3M 3s\n",
      " 31150K .......... .......... .......... .......... .......... 45% 17.4M 3s\n",
      " 31200K .......... .......... .......... .......... .......... 45% 17.5M 3s\n",
      " 31250K .......... .......... .......... .......... .......... 45% 18.0M 3s\n",
      " 31300K .......... .......... .......... .......... .......... 45% 12.0M 3s\n",
      " 31350K .......... .......... .......... .......... .......... 45% 20.6M 3s\n",
      " 31400K .......... .......... .......... .......... .......... 45% 13.2M 3s\n",
      " 31450K .......... .......... .......... .......... .......... 46% 20.8M 3s\n",
      " 31500K .......... .......... .......... .......... .......... 46% 17.9M 3s\n",
      " 31550K .......... .......... .......... .......... .......... 46% 17.3M 3s\n",
      " 31600K .......... .......... .......... .......... .......... 46% 17.6M 3s\n",
      " 31650K .......... .......... .......... .......... .......... 46% 15.2M 3s\n",
      " 31700K .......... .......... .......... .......... .......... 46% 12.3M 3s\n",
      " 31750K .......... .......... .......... .......... .......... 46% 14.3M 3s\n",
      " 31800K .......... .......... .......... .......... .......... 46% 20.4M 3s\n",
      " 31850K .......... .......... .......... .......... .......... 46% 16.8M 3s\n",
      " 31900K .......... .......... .......... .......... .......... 46% 16.7M 3s\n",
      " 31950K .......... .......... .......... .......... .......... 46% 17.4M 3s\n",
      " 32000K .......... .......... .......... .......... .......... 46% 18.0M 3s\n",
      " 32050K .......... .......... .......... .......... .......... 46% 17.5M 3s\n",
      " 32100K .......... .......... .......... .......... .......... 46% 13.3M 3s\n",
      " 32150K .......... .......... .......... .......... .......... 47% 18.2M 3s\n",
      " 32200K .......... .......... .......... .......... .......... 47% 17.8M 3s\n",
      " 32250K .......... .......... .......... .......... .......... 47% 11.0M 3s\n",
      " 32300K .......... .......... .......... .......... .......... 47% 16.8M 3s\n",
      " 32350K .......... .......... .......... .......... .......... 47% 17.5M 3s\n",
      " 32400K .......... .......... .......... .......... .......... 47% 17.4M 3s\n",
      " 32450K .......... .......... .......... .......... .......... 47% 17.4M 3s\n",
      " 32500K .......... .......... .......... .......... .......... 47% 17.9M 3s\n",
      " 32550K .......... .......... .......... .......... .......... 47% 17.6M 3s\n",
      " 32600K .......... .......... .......... .......... .......... 47% 17.4M 3s\n",
      " 32650K .......... .......... .......... .......... .......... 47% 13.4M 3s\n",
      " 32700K .......... .......... .......... .......... .......... 47% 17.3M 3s\n",
      " 32750K .......... .......... .......... .......... .......... 47% 17.0M 3s\n",
      " 32800K .......... .......... .......... .......... .......... 47% 18.3M 3s\n",
      " 32850K .......... .......... .......... .......... .......... 48% 17.1M 3s\n",
      " 32900K .......... .......... .......... .......... .......... 48% 18.0M 3s\n",
      " 32950K .......... .......... .......... .......... .......... 48% 17.8M 3s\n",
      " 33000K .......... .......... .......... .......... .......... 48% 13.3M 3s\n",
      " 33050K .......... .......... .......... .......... .......... 48% 13.3M 3s\n",
      " 33100K .......... .......... .......... .......... .......... 48% 17.5M 3s\n",
      " 33150K .......... .......... .......... .......... .......... 48% 17.4M 3s\n",
      " 33200K .......... .......... .......... .......... .......... 48% 17.7M 3s\n",
      " 33250K .......... .......... .......... .......... .......... 48% 17.7M 3s\n",
      " 33300K .......... .......... .......... .......... .......... 48% 17.4M 3s\n",
      " 33350K .......... .......... .......... .......... .......... 48% 17.7M 3s\n",
      " 33400K .......... .......... .......... .......... .......... 48% 17.4M 3s\n",
      " 33450K .......... .......... .......... .......... .......... 48% 13.3M 3s\n",
      " 33500K .......... .......... .......... .......... .......... 49% 16.9M 3s\n",
      " 33550K .......... .......... .......... .......... .......... 49% 18.5M 3s\n",
      " 33600K .......... .......... .......... .......... .......... 49% 17.7M 3s\n",
      " 33650K .......... .......... .......... .......... .......... 49% 17.3M 3s\n",
      " 33700K .......... .......... .......... .......... .......... 49% 16.9M 3s\n",
      " 33750K .......... .......... .......... .......... .......... 49% 14.7M 3s\n",
      " 33800K .......... .......... .......... .......... .......... 49% 16.3M 3s\n",
      " 33850K .......... .......... .......... .......... .......... 49% 17.7M 3s\n",
      " 33900K .......... .......... .......... .......... .......... 49% 17.1M 3s\n",
      " 33950K .......... .......... .......... .......... .......... 49% 18.1M 3s\n",
      " 34000K .......... .......... .......... .......... .......... 49% 14.0M 3s\n",
      " 34050K .......... .......... .......... .......... .......... 49% 16.4M 3s\n",
      " 34100K .......... .......... .......... .......... .......... 49% 13.3M 3s\n",
      " 34150K .......... .......... .......... .......... .......... 49% 17.5M 3s\n",
      " 34200K .......... .......... .......... .......... .......... 50% 17.4M 3s\n",
      " 34250K .......... .......... .......... .......... .......... 50% 17.9M 3s\n",
      " 34300K .......... .......... .......... .......... .......... 50% 17.4M 3s\n",
      " 34350K .......... .......... .......... .......... .......... 50% 12.5M 3s\n",
      " 34400K .......... .......... .......... .......... .......... 50% 19.0M 3s\n",
      " 34450K .......... .......... .......... .......... .......... 50% 13.2M 3s\n",
      " 34500K .......... .......... .......... .......... .......... 50% 15.3M 3s\n",
      " 34550K .......... .......... .......... .......... .......... 50% 23.0M 3s\n",
      " 34600K .......... .......... .......... .......... .......... 50% 18.8M 3s\n",
      " 34650K .......... .......... .......... .......... .......... 50% 13.5M 3s\n",
      " 34700K .......... .......... .......... .......... .......... 50% 12.7M 3s\n",
      " 34750K .......... .......... .......... .......... .......... 50% 27.6M 3s\n",
      " 34800K .......... .......... .......... .......... .......... 50% 17.8M 3s\n",
      " 34850K .......... .......... .......... .......... .......... 50% 13.0M 3s\n",
      " 34900K .......... .......... .......... .......... .......... 51% 16.6M 3s\n",
      " 34950K .......... .......... .......... .......... .......... 51% 17.0M 3s\n",
      " 35000K .......... .......... .......... .......... .......... 51% 20.7M 3s\n",
      " 35050K .......... .......... .......... .......... .......... 51% 15.4M 3s\n",
      " 35100K .......... .......... .......... .......... .......... 51% 10.3M 3s\n",
      " 35150K .......... .......... .......... .......... .......... 51% 19.0M 3s\n",
      " 35200K .......... .......... .......... .......... .......... 51% 17.3M 3s\n",
      " 35250K .......... .......... .......... .......... .......... 51% 13.7M 3s\n",
      " 35300K .......... .......... .......... .......... .......... 51% 29.1M 3s\n",
      " 35350K .......... .......... .......... .......... .......... 51% 16.5M 3s\n",
      " 35400K .......... .......... .......... .......... .......... 51% 13.2M 3s\n",
      " 35450K .......... .......... .......... .......... .......... 51% 17.3M 3s\n",
      " 35500K .......... .......... .......... .......... .......... 51% 13.5M 3s\n",
      " 35550K .......... .......... .......... .......... .......... 52% 25.6M 3s\n",
      " 35600K .......... .......... .......... .......... .......... 52% 13.4M 3s\n",
      " 35650K .......... .......... .......... .......... .......... 52% 17.8M 3s\n",
      " 35700K .......... .......... .......... .......... .......... 52% 17.4M 3s\n",
      " 35750K .......... .......... .......... .......... .......... 52% 21.1M 3s\n",
      " 35800K .......... .......... .......... .......... .......... 52% 15.3M 3s\n",
      " 35850K .......... .......... .......... .......... .......... 52% 17.1M 3s\n",
      " 35900K .......... .......... .......... .......... .......... 52% 13.4M 3s\n",
      " 35950K .......... .......... .......... .......... .......... 52% 17.1M 3s\n",
      " 36000K .......... .......... .......... .......... .......... 52% 13.6M 3s\n",
      " 36050K .......... .......... .......... .......... .......... 52% 26.5M 3s\n",
      " 36100K .......... .......... .......... .......... .......... 52% 17.1M 3s\n",
      " 36150K .......... .......... .......... .......... .......... 52% 13.4M 3s\n",
      " 36200K .......... .......... .......... .......... .......... 52% 17.4M 3s\n",
      " 36250K .......... .......... .......... .......... .......... 53% 26.1M 3s\n",
      " 36300K .......... .......... .......... .......... .......... 53% 13.5M 3s\n",
      " 36350K .......... .......... .......... .......... .......... 53% 13.2M 3s\n",
      " 36400K .......... .......... .......... .......... .......... 53% 17.3M 3s\n",
      " 36450K .......... .......... .......... .......... .......... 53% 17.9M 3s\n",
      " 36500K .......... .......... .......... .......... .......... 53% 20.9M 3s\n",
      " 36550K .......... .......... .......... .......... .......... 53% 15.1M 3s\n",
      " 36600K .......... .......... .......... .......... .......... 53% 17.1M 3s\n",
      " 36650K .......... .......... .......... .......... .......... 53% 17.9M 3s\n",
      " 36700K .......... .......... .......... .......... .......... 53% 11.2M 3s\n",
      " 36750K .......... .......... .......... .......... .......... 53% 23.0M 3s\n",
      " 36800K .......... .......... .......... .......... .......... 53% 18.2M 3s\n",
      " 36850K .......... .......... .......... .......... .......... 53% 25.8M 3s\n",
      " 36900K .......... .......... .......... .......... .......... 53% 10.5M 3s\n",
      " 36950K .......... .......... .......... .......... .......... 54% 17.4M 3s\n",
      " 37000K .......... .......... .......... .......... .......... 54% 27.1M 3s\n",
      " 37050K .......... .......... .......... .......... .......... 54% 13.9M 3s\n",
      " 37100K .......... .......... .......... .......... .......... 54% 12.7M 3s\n",
      " 37150K .......... .......... .......... .......... .......... 54% 17.5M 3s\n",
      " 37200K .......... .......... .......... .......... .......... 54% 17.6M 3s\n",
      " 37250K .......... .......... .......... .......... .......... 54% 24.4M 3s\n",
      " 37300K .......... .......... .......... .......... .......... 54% 13.6M 3s\n",
      " 37350K .......... .......... .......... .......... .......... 54% 17.8M 3s\n",
      " 37400K .......... .......... .......... .......... .......... 54% 12.5M 3s\n",
      " 37450K .......... .......... .......... .......... .......... 54% 17.8M 3s\n",
      " 37500K .......... .......... .......... .......... .......... 54% 12.2M 3s\n",
      " 37550K .......... .......... .......... .......... .......... 54% 17.9M 3s\n",
      " 37600K .......... .......... .......... .......... .......... 55% 26.6M 3s\n",
      " 37650K .......... .......... .......... .......... .......... 55% 17.3M 3s\n",
      " 37700K .......... .......... .......... .......... .......... 55% 13.3M 3s\n",
      " 37750K .......... .......... .......... .......... .......... 55% 17.4M 3s\n",
      " 37800K .......... .......... .......... .......... .......... 55% 18.6M 3s\n",
      " 37850K .......... .......... .......... .......... .......... 55% 16.6M 3s\n",
      " 37900K .......... .......... .......... .......... .......... 55% 13.1M 3s\n",
      " 37950K .......... .......... .......... .......... .......... 55% 16.8M 3s\n",
      " 38000K .......... .......... .......... .......... .......... 55% 16.8M 3s\n",
      " 38050K .......... .......... .......... .......... .......... 55% 12.8M 3s\n",
      " 38100K .......... .......... .......... .......... .......... 55% 28.5M 3s\n",
      " 38150K .......... .......... .......... .......... .......... 55% 17.7M 3s\n",
      " 38200K .......... .......... .......... .......... .......... 55% 11.0M 3s\n",
      " 38250K .......... .......... .......... .......... .......... 55% 14.8M 3s\n",
      " 38300K .......... .......... .......... .......... .......... 56% 15.2M 3s\n",
      " 38350K .......... .......... .......... .......... .......... 56% 30.8M 3s\n",
      " 38400K .......... .......... .......... .......... .......... 56% 16.0M 3s\n",
      " 38450K .......... .......... .......... .......... .......... 56% 13.3M 3s\n",
      " 38500K .......... .......... .......... .......... .......... 56% 17.1M 3s\n",
      " 38550K .......... .......... .......... .......... .......... 56% 27.2M 3s\n",
      " 38600K .......... .......... .......... .......... .......... 56% 13.1M 3s\n",
      " 38650K .......... .......... .......... .......... .......... 56% 13.4M 3s\n",
      " 38700K .......... .......... .......... .......... .......... 56% 17.7M 3s\n",
      " 38750K .......... .......... .......... .......... .......... 56% 17.5M 3s\n",
      " 38800K .......... .......... .......... .......... .......... 56% 12.9M 3s\n",
      " 38850K .......... .......... .......... .......... .......... 56% 27.8M 3s\n",
      " 38900K .......... .......... .......... .......... .......... 56% 17.1M 3s\n",
      " 38950K .......... .......... .......... .......... .......... 56% 15.7M 3s\n",
      " 39000K .......... .......... .......... .......... .......... 57% 12.9M 3s\n",
      " 39050K .......... .......... .......... .......... .......... 57% 15.1M 3s\n",
      " 39100K .......... .......... .......... .......... .......... 57% 26.9M 3s\n",
      " 39150K .......... .......... .......... .......... .......... 57% 17.3M 3s\n",
      " 39200K .......... .......... .......... .......... .......... 57% 13.1M 3s\n",
      " 39250K .......... .......... .......... .......... .......... 57% 17.4M 3s\n",
      " 39300K .......... .......... .......... .......... .......... 57% 26.7M 3s\n",
      " 39350K .......... .......... .......... .......... .......... 57% 13.4M 3s\n",
      " 39400K .......... .......... .......... .......... .......... 57% 13.2M 3s\n",
      " 39450K .......... .......... .......... .......... .......... 57% 17.0M 2s\n",
      " 39500K .......... .......... .......... .......... .......... 57% 17.9M 2s\n",
      " 39550K .......... .......... .......... .......... .......... 57% 13.8M 2s\n",
      " 39600K .......... .......... .......... .......... .......... 57% 24.7M 2s\n",
      " 39650K .......... .......... .......... .......... .......... 58% 17.0M 2s\n",
      " 39700K .......... .......... .......... .......... .......... 58% 16.2M 2s\n",
      " 39750K .......... .......... .......... .......... .......... 58% 15.3M 2s\n",
      " 39800K .......... .......... .......... .......... .......... 58% 16.3M 2s\n",
      " 39850K .......... .......... .......... .......... .......... 58% 18.3M 2s\n",
      " 39900K .......... .......... .......... .......... .......... 58% 25.8M 2s\n",
      " 39950K .......... .......... .......... .......... .......... 58% 10.6M 2s\n",
      " 40000K .......... .......... .......... .......... .......... 58% 17.2M 2s\n",
      " 40050K .......... .......... .......... .......... .......... 58% 27.4M 2s\n",
      " 40100K .......... .......... .......... .......... .......... 58% 13.1M 2s\n",
      " 40150K .......... .......... .......... .......... .......... 58% 26.7M 2s\n",
      " 40200K .......... .......... .......... .......... .......... 58% 10.5M 2s\n",
      " 40250K .......... .......... .......... .......... .......... 58% 18.1M 2s\n",
      " 40300K .......... .......... .......... .......... .......... 58% 12.9M 2s\n",
      " 40350K .......... .......... .......... .......... .......... 59% 26.6M 2s\n",
      " 40400K .......... .......... .......... .......... .......... 59% 17.7M 2s\n",
      " 40450K .......... .......... .......... .......... .......... 59% 15.9M 2s\n",
      " 40500K .......... .......... .......... .......... .......... 59% 13.6M 2s\n",
      " 40550K .......... .......... .......... .......... .......... 59% 13.8M 2s\n",
      " 40600K .......... .......... .......... .......... .......... 59% 15.4M 2s\n",
      " 40650K .......... .......... .......... .......... .......... 59% 26.8M 2s\n",
      " 40700K .......... .......... .......... .......... .......... 59% 13.2M 2s\n",
      " 40750K .......... .......... .......... .......... .......... 59% 17.3M 2s\n",
      " 40800K .......... .......... .......... .......... .......... 59% 17.3M 2s\n",
      " 40850K .......... .......... .......... .......... .......... 59% 18.2M 2s\n",
      " 40900K .......... .......... .......... .......... .......... 59% 17.3M 2s\n",
      " 40950K .......... .......... .......... .......... .......... 59% 14.2M 2s\n",
      " 41000K .......... .......... .......... .......... .......... 59% 14.9M 2s\n",
      " 41050K .......... .......... .......... .......... .......... 60% 12.6M 2s\n",
      " 41100K .......... .......... .......... .......... .......... 60% 17.3M 2s\n",
      " 41150K .......... .......... .......... .......... .......... 60% 27.6M 2s\n",
      " 41200K .......... .......... .......... .......... .......... 60% 15.9M 2s\n",
      " 41250K .......... .......... .......... .......... .......... 60% 11.8M 2s\n",
      " 41300K .......... .......... .......... .......... .......... 60% 17.4M 2s\n",
      " 41350K .......... .......... .......... .......... .......... 60% 27.0M 2s\n",
      " 41400K .......... .......... .......... .......... .......... 60% 13.8M 2s\n",
      " 41450K .......... .......... .......... .......... .......... 60% 12.8M 2s\n",
      " 41500K .......... .......... .......... .......... .......... 60% 17.7M 2s\n",
      " 41550K .......... .......... .......... .......... .......... 60% 16.8M 2s\n",
      " 41600K .......... .......... .......... .......... .......... 60% 13.5M 2s\n",
      " 41650K .......... .......... .......... .......... .......... 60% 26.8M 2s\n",
      " 41700K .......... .......... .......... .......... .......... 60% 17.5M 2s\n",
      " 41750K .......... .......... .......... .......... .......... 61% 13.9M 2s\n",
      " 41800K .......... .......... .......... .......... .......... 61% 12.6M 2s\n",
      " 41850K .......... .......... .......... .......... .......... 61% 17.3M 2s\n",
      " 41900K .......... .......... .......... .......... .......... 61% 27.8M 2s\n",
      " 41950K .......... .......... .......... .......... .......... 61% 15.4M 2s\n",
      " 42000K .......... .......... .......... .......... .......... 61% 15.2M 2s\n",
      " 42050K .......... .......... .......... .......... .......... 61% 13.1M 2s\n",
      " 42100K .......... .......... .......... .......... .......... 61% 17.1M 2s\n",
      " 42150K .......... .......... .......... .......... .......... 61% 28.0M 2s\n",
      " 42200K .......... .......... .......... .......... .......... 61% 12.9M 2s\n",
      " 42250K .......... .......... .......... .......... .......... 61% 17.3M 2s\n",
      " 42300K .......... .......... .......... .......... .......... 61% 17.4M 2s\n",
      " 42350K .......... .......... .......... .......... .......... 61% 13.9M 2s\n",
      " 42400K .......... .......... .......... .......... .......... 62% 24.3M 2s\n",
      " 42450K .......... .......... .......... .......... .......... 62% 17.1M 2s\n",
      " 42500K .......... .......... .......... .......... .......... 62% 14.7M 2s\n",
      " 42550K .......... .......... .......... .......... .......... 62% 15.4M 2s\n",
      " 42600K .......... .......... .......... .......... .......... 62% 14.0M 2s\n",
      " 42650K .......... .......... .......... .......... .......... 62% 26.3M 2s\n",
      " 42700K .......... .......... .......... .......... .......... 62% 15.1M 2s\n",
      " 42750K .......... .......... .......... .......... .......... 62% 13.6M 2s\n",
      " 42800K .......... .......... .......... .......... .......... 62% 19.2M 2s\n",
      " 42850K .......... .......... .......... .......... .......... 62% 17.5M 2s\n",
      " 42900K .......... .......... .......... .......... .......... 62% 12.6M 2s\n",
      " 42950K .......... .......... .......... .......... .......... 62% 42.5M 2s\n",
      " 43000K .......... .......... .......... .......... .......... 62% 11.6M 2s\n",
      " 43050K .......... .......... .......... .......... .......... 62% 17.6M 2s\n",
      " 43100K .......... .......... .......... .......... .......... 63% 14.2M 2s\n",
      " 43150K .......... .......... .......... .......... .......... 63% 22.9M 2s\n",
      " 43200K .......... .......... .......... .......... .......... 63% 25.4M 2s\n",
      " 43250K .......... .......... .......... .......... .......... 63% 11.2M 2s\n",
      " 43300K .......... .......... .......... .......... .......... 63% 16.9M 2s\n",
      " 43350K .......... .......... .......... .......... .......... 63% 25.3M 2s\n",
      " 43400K .......... .......... .......... .......... .......... 63% 13.2M 2s\n",
      " 43450K .......... .......... .......... .......... .......... 63% 15.9M 2s\n",
      " 43500K .......... .......... .......... .......... .......... 63% 13.6M 2s\n",
      " 43550K .......... .......... .......... .......... .......... 63% 17.3M 2s\n",
      " 43600K .......... .......... .......... .......... .......... 63% 13.8M 2s\n",
      " 43650K .......... .......... .......... .......... .......... 63% 15.8M 2s\n",
      " 43700K .......... .......... .......... .......... .......... 63% 26.4M 2s\n",
      " 43750K .......... .......... .......... .......... .......... 63% 13.9M 2s\n",
      " 43800K .......... .......... .......... .......... .......... 64% 15.9M 2s\n",
      " 43850K .......... .......... .......... .......... .......... 64% 18.0M 2s\n",
      " 43900K .......... .......... .......... .......... .......... 64% 18.4M 2s\n",
      " 43950K .......... .......... .......... .......... .......... 64% 15.6M 2s\n",
      " 44000K .......... .......... .......... .......... .......... 64% 13.0M 2s\n",
      " 44050K .......... .......... .......... .......... .......... 64% 18.3M 2s\n",
      " 44100K .......... .......... .......... .......... .......... 64% 16.8M 2s\n",
      " 44150K .......... .......... .......... .......... .......... 64% 13.4M 2s\n",
      " 44200K .......... .......... .......... .......... .......... 64% 27.8M 2s\n",
      " 44250K .......... .......... .......... .......... .......... 64% 16.8M 2s\n",
      " 44300K .......... .......... .......... .......... .......... 64% 11.0M 2s\n",
      " 44350K .......... .......... .......... .......... .......... 64% 14.0M 2s\n",
      " 44400K .......... .......... .......... .......... .......... 64% 16.3M 2s\n",
      " 44450K .......... .......... .......... .......... .......... 65% 30.1M 2s\n",
      " 44500K .......... .......... .......... .......... .......... 65% 15.7M 2s\n",
      " 44550K .......... .......... .......... .......... .......... 65% 13.6M 2s\n",
      " 44600K .......... .......... .......... .......... .......... 65% 17.0M 2s\n",
      " 44650K .......... .......... .......... .......... .......... 65% 26.8M 2s\n",
      " 44700K .......... .......... .......... .......... .......... 65% 12.6M 2s\n",
      " 44750K .......... .......... .......... .......... .......... 65% 14.1M 2s\n",
      " 44800K .......... .......... .......... .......... .......... 65% 17.9M 2s\n",
      " 44850K .......... .......... .......... .......... .......... 65% 17.4M 2s\n",
      " 44900K .......... .......... .......... .......... .......... 65% 13.8M 2s\n",
      " 44950K .......... .......... .......... .......... .......... 65% 27.6M 2s\n",
      " 45000K .......... .......... .......... .......... .......... 65% 15.7M 2s\n",
      " 45050K .......... .......... .......... .......... .......... 65% 17.0M 2s\n",
      " 45100K .......... .......... .......... .......... .......... 65% 8.03M 2s\n",
      " 45150K .......... .......... .......... .......... .......... 66% 27.6M 2s\n",
      " 45200K .......... .......... .......... .......... .......... 66% 26.5M 2s\n",
      " 45250K .......... .......... .......... .......... .......... 66% 21.9M 2s\n",
      " 45300K .......... .......... .......... .......... .......... 66% 13.5M 2s\n",
      " 45350K .......... .......... .......... .......... .......... 66% 17.4M 2s\n",
      " 45400K .......... .......... .......... .......... .......... 66% 25.6M 2s\n",
      " 45450K .......... .......... .......... .......... .......... 66% 14.4M 2s\n",
      " 45500K .......... .......... .......... .......... .......... 66% 12.5M 2s\n",
      " 45550K .......... .......... .......... .......... .......... 66% 18.5M 2s\n",
      " 45600K .......... .......... .......... .......... .......... 66% 15.9M 2s\n",
      " 45650K .......... .......... .......... .......... .......... 66% 14.7M 2s\n",
      " 45700K .......... .......... .......... .......... .......... 66% 24.6M 2s\n",
      " 45750K .......... .......... .......... .......... .......... 66% 16.5M 2s\n",
      " 45800K .......... .......... .......... .......... .......... 66% 17.4M 2s\n",
      " 45850K .......... .......... .......... .......... .......... 67% 13.8M 2s\n",
      " 45900K .......... .......... .......... .......... .......... 67% 10.8M 2s\n",
      " 45950K .......... .......... .......... .......... .......... 67% 20.7M 2s\n",
      " 46000K .......... .......... .......... .......... .......... 67% 29.5M 2s\n",
      " 46050K .......... .......... .......... .......... .......... 67% 13.9M 2s\n",
      " 46100K .......... .......... .......... .......... .......... 67% 17.4M 2s\n",
      " 46150K .......... .......... .......... .......... .......... 67% 26.1M 2s\n",
      " 46200K .......... .......... .......... .......... .......... 67% 13.8M 2s\n",
      " 46250K .......... .......... .......... .......... .......... 67% 23.0M 2s\n",
      " 46300K .......... .......... .......... .......... .......... 67% 11.0M 2s\n",
      " 46350K .......... .......... .......... .......... .......... 67% 17.9M 2s\n",
      " 46400K .......... .......... .......... .......... .......... 67% 13.6M 2s\n",
      " 46450K .......... .......... .......... .......... .......... 67% 23.3M 2s\n",
      " 46500K .......... .......... .......... .......... .......... 68% 17.2M 2s\n",
      " 46550K .......... .......... .......... .......... .......... 68% 17.1M 2s\n",
      " 46600K .......... .......... .......... .......... .......... 68% 13.3M 2s\n",
      " 46650K .......... .......... .......... .......... .......... 68% 13.1M 2s\n",
      " 46700K .......... .......... .......... .......... .......... 68% 16.4M 2s\n",
      " 46750K .......... .......... .......... .......... .......... 68% 26.3M 2s\n",
      " 46800K .......... .......... .......... .......... .......... 68% 13.1M 2s\n",
      " 46850K .......... .......... .......... .......... .......... 68% 17.2M 2s\n",
      " 46900K .......... .......... .......... .......... .......... 68% 17.5M 2s\n",
      " 46950K .......... .......... .......... .......... .......... 68% 18.7M 2s\n",
      " 47000K .......... .......... .......... .......... .......... 68% 17.2M 2s\n",
      " 47050K .......... .......... .......... .......... .......... 68% 14.1M 2s\n",
      " 47100K .......... .......... .......... .......... .......... 68% 14.9M 2s\n",
      " 47150K .......... .......... .......... .......... .......... 68% 13.4M 2s\n",
      " 47200K .......... .......... .......... .......... .......... 69% 15.9M 2s\n",
      " 47250K .......... .......... .......... .......... .......... 69% 30.9M 2s\n",
      " 47300K .......... .......... .......... .......... .......... 69% 16.4M 2s\n",
      " 47350K .......... .......... .......... .......... .......... 69% 10.8M 2s\n",
      " 47400K .......... .......... .......... .......... .......... 69% 18.3M 2s\n",
      " 47450K .......... .......... .......... .......... .......... 69% 26.0M 2s\n",
      " 47500K .......... .......... .......... .......... .......... 69% 14.0M 2s\n",
      " 47550K .......... .......... .......... .......... .......... 69% 12.9M 2s\n",
      " 47600K .......... .......... .......... .......... .......... 69% 17.5M 2s\n",
      " 47650K .......... .......... .......... .......... .......... 69% 16.6M 2s\n",
      " 47700K .......... .......... .......... .......... .......... 69% 13.7M 2s\n",
      " 47750K .......... .......... .......... .......... .......... 69% 26.5M 2s\n",
      " 47800K .......... .......... .......... .......... .......... 69% 17.1M 2s\n",
      " 47850K .......... .......... .......... .......... .......... 69% 15.4M 2s\n",
      " 47900K .......... .......... .......... .......... .......... 70% 12.5M 2s\n",
      " 47950K .......... .......... .......... .......... .......... 70% 16.2M 2s\n",
      " 48000K .......... .......... .......... .......... .......... 70% 30.5M 2s\n",
      " 48050K .......... .......... .......... .......... .......... 70% 15.5M 2s\n",
      " 48100K .......... .......... .......... .......... .......... 70% 15.1M 2s\n",
      " 48150K .......... .......... .......... .......... .......... 70% 12.6M 2s\n",
      " 48200K .......... .......... .......... .......... .......... 70% 17.9M 2s\n",
      " 48250K .......... .......... .......... .......... .......... 70% 18.2M 2s\n",
      " 48300K .......... .......... .......... .......... .......... 70% 16.3M 2s\n",
      " 48350K .......... .......... .......... .......... .......... 70% 17.4M 2s\n",
      " 48400K .......... .......... .......... .......... .......... 70% 16.9M 2s\n",
      " 48450K .......... .......... .......... .......... .......... 70% 13.3M 2s\n",
      " 48500K .......... .......... .......... .......... .......... 70% 29.9M 2s\n",
      " 48550K .......... .......... .......... .......... .......... 71% 16.3M 2s\n",
      " 48600K .......... .......... .......... .......... .......... 71% 15.0M 2s\n",
      " 48650K .......... .......... .......... .......... .......... 71% 14.6M 2s\n",
      " 48700K .......... .......... .......... .......... .......... 71% 13.7M 2s\n",
      " 48750K .......... .......... .......... .......... .......... 71% 29.7M 2s\n",
      " 48800K .......... .......... .......... .......... .......... 71% 16.0M 2s\n",
      " 48850K .......... .......... .......... .......... .......... 71% 12.9M 2s\n",
      " 48900K .......... .......... .......... .......... .......... 71% 19.0M 2s\n",
      " 48950K .......... .......... .......... .......... .......... 71% 17.1M 2s\n",
      " 49000K .......... .......... .......... .......... .......... 71% 12.2M 2s\n",
      " 49050K .......... .......... .......... .......... .......... 71% 31.2M 2s\n",
      " 49100K .......... .......... .......... .......... .......... 71% 13.8M 2s\n",
      " 49150K .......... .......... .......... .......... .......... 71% 17.0M 2s\n",
      " 49200K .......... .......... .......... .......... .......... 71% 12.2M 2s\n",
      " 49250K .......... .......... .......... .......... .......... 72% 30.8M 2s\n",
      " 49300K .......... .......... .......... .......... .......... 72% 23.6M 2s\n",
      " 49350K .......... .......... .......... .......... .......... 72% 12.7M 2s\n",
      " 49400K .......... .......... .......... .......... .......... 72% 15.4M 2s\n",
      " 49450K .......... .......... .......... .......... .......... 72% 26.0M 2s\n",
      " 49500K .......... .......... .......... .......... .......... 72% 13.0M 2s\n",
      " 49550K .......... .......... .......... .......... .......... 72% 16.6M 2s\n",
      " 49600K .......... .......... .......... .......... .......... 72% 13.3M 2s\n",
      " 49650K .......... .......... .......... .......... .......... 72% 17.9M 2s\n",
      " 49700K .......... .......... .......... .......... .......... 72% 12.7M 2s\n",
      " 49750K .......... .......... .......... .......... .......... 72% 16.6M 2s\n",
      " 49800K .......... .......... .......... .......... .......... 72% 27.7M 2s\n",
      " 49850K .......... .......... .......... .......... .......... 72% 16.9M 1s\n",
      " 49900K .......... .......... .......... .......... .......... 72% 12.9M 1s\n",
      " 49950K .......... .......... .......... .......... .......... 73% 13.0M 1s\n",
      " 50000K .......... .......... .......... .......... .......... 73% 30.8M 1s\n",
      " 50050K .......... .......... .......... .......... .......... 73% 17.6M 1s\n",
      " 50100K .......... .......... .......... .......... .......... 73% 12.3M 1s\n",
      " 50150K .......... .......... .......... .......... .......... 73% 17.2M 1s\n",
      " 50200K .......... .......... .......... .......... .......... 73% 17.3M 1s\n",
      " 50250K .......... .......... .......... .......... .......... 73% 26.1M 1s\n",
      " 50300K .......... .......... .......... .......... .......... 73% 13.1M 1s\n",
      " 50350K .......... .......... .......... .......... .......... 73% 10.2M 1s\n",
      " 50400K .......... .......... .......... .......... .......... 73% 19.5M 1s\n",
      " 50450K .......... .......... .......... .......... .......... 73% 17.7M 1s\n",
      " 50500K .......... .......... .......... .......... .......... 73% 13.3M 1s\n",
      " 50550K .......... .......... .......... .......... .......... 73% 29.7M 1s\n",
      " 50600K .......... .......... .......... .......... .......... 74% 16.2M 1s\n",
      " 50650K .......... .......... .......... .......... .......... 74% 13.6M 1s\n",
      " 50700K .......... .......... .......... .......... .......... 74% 13.9M 1s\n",
      " 50750K .......... .......... .......... .......... .......... 74% 16.7M 1s\n",
      " 50800K .......... .......... .......... .......... .......... 74% 26.5M 1s\n",
      " 50850K .......... .......... .......... .......... .......... 74% 14.2M 1s\n",
      " 50900K .......... .......... .......... .......... .......... 74% 15.8M 1s\n",
      " 50950K .......... .......... .......... .......... .......... 74% 17.4M 1s\n",
      " 51000K .......... .......... .......... .......... .......... 74% 27.8M 1s\n",
      " 51050K .......... .......... .......... .......... .......... 74% 13.9M 1s\n",
      " 51100K .......... .......... .......... .......... .......... 74% 13.1M 1s\n",
      " 51150K .......... .......... .......... .......... .......... 74% 18.3M 1s\n",
      " 51200K .......... .......... .......... .......... .......... 74% 12.4M 1s\n",
      " 51250K .......... .......... .......... .......... .......... 74% 14.0M 1s\n",
      " 51300K .......... .......... .......... .......... .......... 75% 23.1M 1s\n",
      " 51350K .......... .......... .......... .......... .......... 75% 27.0M 1s\n",
      " 51400K .......... .......... .......... .......... .......... 75% 12.8M 1s\n",
      " 51450K .......... .......... .......... .......... .......... 75% 17.5M 1s\n",
      " 51500K .......... .......... .......... .......... .......... 75% 25.5M 1s\n",
      " 51550K .......... .......... .......... .......... .......... 75% 14.5M 1s\n",
      " 51600K .......... .......... .......... .......... .......... 75% 16.1M 1s\n",
      " 51650K .......... .......... .......... .......... .......... 75% 17.0M 1s\n",
      " 51700K .......... .......... .......... .......... .......... 75% 12.7M 1s\n",
      " 51750K .......... .......... .......... .......... .......... 75% 14.0M 1s\n",
      " 51800K .......... .......... .......... .......... .......... 75% 27.7M 1s\n",
      " 51850K .......... .......... .......... .......... .......... 75% 16.5M 1s\n",
      " 51900K .......... .......... .......... .......... .......... 75% 13.0M 1s\n",
      " 51950K .......... .......... .......... .......... .......... 75% 19.3M 1s\n",
      " 52000K .......... .......... .......... .......... .......... 76% 17.2M 1s\n",
      " 52050K .......... .......... .......... .......... .......... 76% 15.1M 1s\n",
      " 52100K .......... .......... .......... .......... .......... 76% 14.9M 1s\n",
      " 52150K .......... .......... .......... .......... .......... 76% 18.4M 1s\n",
      " 52200K .......... .......... .......... .......... .......... 76% 17.3M 1s\n",
      " 52250K .......... .......... .......... .......... .......... 76% 27.6M 1s\n",
      " 52300K .......... .......... .......... .......... .......... 76% 12.5M 1s\n",
      " 52350K .......... .......... .......... .......... .......... 76% 24.3M 1s\n",
      " 52400K .......... .......... .......... .......... .......... 76% 14.0M 1s\n",
      " 52450K .......... .......... .......... .......... .......... 76% 13.9M 1s\n",
      " 52500K .......... .......... .......... .......... .......... 76% 12.9M 1s\n",
      " 52550K .......... .......... .......... .......... .......... 76% 26.1M 1s\n",
      " 52600K .......... .......... .......... .......... .......... 76% 16.8M 1s\n",
      " 52650K .......... .......... .......... .......... .......... 76% 13.2M 1s\n",
      " 52700K .......... .......... .......... .......... .......... 77% 17.7M 1s\n",
      " 52750K .......... .......... .......... .......... .......... 77% 11.2M 1s\n",
      " 52800K .......... .......... .......... .......... .......... 77% 20.5M 1s\n",
      " 52850K .......... .......... .......... .......... .......... 77% 27.6M 1s\n",
      " 52900K .......... .......... .......... .......... .......... 77% 12.9M 1s\n",
      " 52950K .......... .......... .......... .......... .......... 77% 17.1M 1s\n",
      " 53000K .......... .......... .......... .......... .......... 77% 17.9M 1s\n",
      " 53050K .......... .......... .......... .......... .......... 77% 18.0M 1s\n",
      " 53100K .......... .......... .......... .......... .......... 77% 17.2M 1s\n",
      " 53150K .......... .......... .......... .......... .......... 77% 12.0M 1s\n",
      " 53200K .......... .......... .......... .......... .......... 77% 18.7M 1s\n",
      " 53250K .......... .......... .......... .......... .......... 77% 17.0M 1s\n",
      " 53300K .......... .......... .......... .......... .......... 77% 21.8M 1s\n",
      " 53350K .......... .......... .......... .......... .......... 78% 12.1M 1s\n",
      " 53400K .......... .......... .......... .......... .......... 78% 11.8M 1s\n",
      " 53450K .......... .......... .......... .......... .......... 78% 19.6M 1s\n",
      " 53500K .......... .......... .......... .......... .......... 78% 18.2M 1s\n",
      " 53550K .......... .......... .......... .......... .......... 78% 20.5M 1s\n",
      " 53600K .......... .......... .......... .......... .......... 78% 16.3M 1s\n",
      " 53650K .......... .......... .......... .......... .......... 78% 13.5M 1s\n",
      " 53700K .......... .......... .......... .......... .......... 78% 16.3M 1s\n",
      " 53750K .......... .......... .......... .......... .......... 78% 16.9M 1s\n",
      " 53800K .......... .......... .......... .......... .......... 78% 20.9M 1s\n",
      " 53850K .......... .......... .......... .......... .......... 78% 15.9M 1s\n",
      " 53900K .......... .......... .......... .......... .......... 78% 12.8M 1s\n",
      " 53950K .......... .......... .......... .......... .......... 78% 18.3M 1s\n",
      " 54000K .......... .......... .......... .......... .......... 78% 17.1M 1s\n",
      " 54050K .......... .......... .......... .......... .......... 79% 14.1M 1s\n",
      " 54100K .......... .......... .......... .......... .......... 79% 26.8M 1s\n",
      " 54150K .......... .......... .......... .......... .......... 79% 15.9M 1s\n",
      " 54200K .......... .......... .......... .......... .......... 79% 15.7M 1s\n",
      " 54250K .......... .......... .......... .......... .......... 79% 12.0M 1s\n",
      " 54300K .......... .......... .......... .......... .......... 79% 13.8M 1s\n",
      " 54350K .......... .......... .......... .......... .......... 79% 23.9M 1s\n",
      " 54400K .......... .......... .......... .......... .......... 79% 17.5M 1s\n",
      " 54450K .......... .......... .......... .......... .......... 79% 17.1M 1s\n",
      " 54500K .......... .......... .......... .......... .......... 79% 17.2M 1s\n",
      " 54550K .......... .......... .......... .......... .......... 79% 25.5M 1s\n",
      " 54600K .......... .......... .......... .......... .......... 79% 14.4M 1s\n",
      " 54650K .......... .......... .......... .......... .......... 79% 16.3M 1s\n",
      " 54700K .......... .......... .......... .......... .......... 79% 14.2M 1s\n",
      " 54750K .......... .......... .......... .......... .......... 80% 15.3M 1s\n",
      " 54800K .......... .......... .......... .......... .......... 80% 14.4M 1s\n",
      " 54850K .......... .......... .......... .......... .......... 80% 22.7M 1s\n",
      " 54900K .......... .......... .......... .......... .......... 80% 17.9M 1s\n",
      " 54950K .......... .......... .......... .......... .......... 80% 13.5M 1s\n",
      " 55000K .......... .......... .......... .......... .......... 80% 18.1M 1s\n",
      " 55050K .......... .......... .......... .......... .......... 80% 17.1M 1s\n",
      " 55100K .......... .......... .......... .......... .......... 80% 12.2M 1s\n",
      " 55150K .......... .......... .......... .......... .......... 80% 20.8M 1s\n",
      " 55200K .......... .......... .......... .......... .......... 80% 17.3M 1s\n",
      " 55250K .......... .......... .......... .......... .......... 80% 17.3M 1s\n",
      " 55300K .......... .......... .......... .......... .......... 80% 29.3M 1s\n",
      " 55350K .......... .......... .......... .......... .......... 80% 12.2M 1s\n",
      " 55400K .......... .......... .......... .......... .......... 81% 24.4M 1s\n",
      " 55450K .......... .......... .......... .......... .......... 81% 14.3M 1s\n",
      " 55500K .......... .......... .......... .......... .......... 81% 13.6M 1s\n",
      " 55550K .......... .......... .......... .......... .......... 81% 13.3M 1s\n",
      " 55600K .......... .......... .......... .......... .......... 81% 23.8M 1s\n",
      " 55650K .......... .......... .......... .......... .......... 81% 17.1M 1s\n",
      " 55700K .......... .......... .......... .......... .......... 81% 13.8M 1s\n",
      " 55750K .......... .......... .......... .......... .......... 81% 16.1M 1s\n",
      " 55800K .......... .......... .......... .......... .......... 81% 13.5M 1s\n",
      " 55850K .......... .......... .......... .......... .......... 81% 28.9M 1s\n",
      " 55900K .......... .......... .......... .......... .......... 81% 9.93M 1s\n",
      " 55950K .......... .......... .......... .......... .......... 81% 25.3M 1s\n",
      " 56000K .......... .......... .......... .......... .......... 81% 17.0M 1s\n",
      " 56050K .......... .......... .......... .......... .......... 81% 16.8M 1s\n",
      " 56100K .......... .......... .......... .......... .......... 82% 19.4M 1s\n",
      " 56150K .......... .......... .......... .......... .......... 82% 17.3M 1s\n",
      " 56200K .......... .......... .......... .......... .......... 82% 14.2M 1s\n",
      " 56250K .......... .......... .......... .......... .......... 82% 17.5M 1s\n",
      " 56300K .......... .......... .......... .......... .......... 82% 11.9M 1s\n",
      " 56350K .......... .......... .......... .......... .......... 82% 15.4M 1s\n",
      " 56400K .......... .......... .......... .......... .......... 82% 30.0M 1s\n",
      " 56450K .......... .......... .......... .......... .......... 82% 10.4M 1s\n",
      " 56500K .......... .......... .......... .......... .......... 82% 18.1M 1s\n",
      " 56550K .......... .......... .......... .......... .......... 82% 18.0M 1s\n",
      " 56600K .......... .......... .......... .......... .......... 82% 25.8M 1s\n",
      " 56650K .......... .......... .......... .......... .......... 82% 14.2M 1s\n",
      " 56700K .......... .......... .......... .......... .......... 82% 13.3M 1s\n",
      " 56750K .......... .......... .......... .......... .......... 82% 17.3M 1s\n",
      " 56800K .......... .......... .......... .......... .......... 83% 16.0M 1s\n",
      " 56850K .......... .......... .......... .......... .......... 83% 13.9M 1s\n",
      " 56900K .......... .......... .......... .......... .......... 83% 26.3M 1s\n",
      " 56950K .......... .......... .......... .......... .......... 83% 17.5M 1s\n",
      " 57000K .......... .......... .......... .......... .......... 83% 15.0M 1s\n",
      " 57050K .......... .......... .......... .......... .......... 83% 14.7M 1s\n",
      " 57100K .......... .......... .......... .......... .......... 83% 13.5M 1s\n",
      " 57150K .......... .......... .......... .......... .......... 83% 30.4M 1s\n",
      " 57200K .......... .......... .......... .......... .......... 83% 13.9M 1s\n",
      " 57250K .......... .......... .......... .......... .......... 83% 16.1M 1s\n",
      " 57300K .......... .......... .......... .......... .......... 83% 13.0M 1s\n",
      " 57350K .......... .......... .......... .......... .......... 83% 18.0M 1s\n",
      " 57400K .......... .......... .......... .......... .......... 83% 16.8M 1s\n",
      " 57450K .......... .......... .......... .......... .......... 84% 26.1M 1s\n",
      " 57500K .......... .......... .......... .......... .......... 84% 13.1M 1s\n",
      " 57550K .......... .......... .......... .......... .......... 84% 17.0M 1s\n",
      " 57600K .......... .......... .......... .......... .......... 84% 13.9M 1s\n",
      " 57650K .......... .......... .......... .......... .......... 84% 25.2M 1s\n",
      " 57700K .......... .......... .......... .......... .......... 84% 17.3M 1s\n",
      " 57750K .......... .......... .......... .......... .......... 84% 15.0M 1s\n",
      " 57800K .......... .......... .......... .......... .......... 84% 14.3M 1s\n",
      " 57850K .......... .......... .......... .......... .......... 84% 26.5M 1s\n",
      " 57900K .......... .......... .......... .......... .......... 84% 13.3M 1s\n",
      " 57950K .......... .......... .......... .......... .......... 84% 15.4M 1s\n",
      " 58000K .......... .......... .......... .......... .......... 84% 14.8M 1s\n",
      " 58050K .......... .......... .......... .......... .......... 84% 19.3M 1s\n",
      " 58100K .......... .......... .......... .......... .......... 84% 16.5M 1s\n",
      " 58150K .......... .......... .......... .......... .......... 85% 12.3M 1s\n",
      " 58200K .......... .......... .......... .......... .......... 85% 30.5M 1s\n",
      " 58250K .......... .......... .......... .......... .......... 85% 17.9M 1s\n",
      " 58300K .......... .......... .......... .......... .......... 85% 13.3M 1s\n",
      " 58350K .......... .......... .......... .......... .......... 85% 12.2M 1s\n",
      " 58400K .......... .......... .......... .......... .......... 85% 30.7M 1s\n",
      " 58450K .......... .......... .......... .......... .......... 85% 23.7M 1s\n",
      " 58500K .......... .......... .......... .......... .......... 85% 12.7M 1s\n",
      " 58550K .......... .......... .......... .......... .......... 85% 15.5M 1s\n",
      " 58600K .......... .......... .......... .......... .......... 85% 24.7M 1s\n",
      " 58650K .......... .......... .......... .......... .......... 85% 19.0M 1s\n",
      " 58700K .......... .......... .......... .......... .......... 85% 12.0M 1s\n",
      " 58750K .......... .......... .......... .......... .......... 85% 13.4M 1s\n",
      " 58800K .......... .......... .......... .......... .......... 85% 18.4M 1s\n",
      " 58850K .......... .......... .......... .......... .......... 86% 12.6M 1s\n",
      " 58900K .......... .......... .......... .......... .......... 86% 15.9M 1s\n",
      " 58950K .......... .......... .......... .......... .......... 86% 27.8M 1s\n",
      " 59000K .......... .......... .......... .......... .......... 86% 18.0M 1s\n",
      " 59050K .......... .......... .......... .......... .......... 86% 12.6M 1s\n",
      " 59100K .......... .......... .......... .......... .......... 86% 12.9M 1s\n",
      " 59150K .......... .......... .......... .......... .......... 86% 30.3M 1s\n",
      " 59200K .......... .......... .......... .......... .......... 86% 17.6M 1s\n",
      " 59250K .......... .......... .......... .......... .......... 86% 13.8M 1s\n",
      " 59300K .......... .......... .......... .......... .......... 86% 15.1M 1s\n",
      " 59350K .......... .......... .......... .......... .......... 86% 12.8M 1s\n",
      " 59400K .......... .......... .......... .......... .......... 86% 16.5M 1s\n",
      " 59450K .......... .......... .......... .......... .......... 86% 30.8M 1s\n",
      " 59500K .......... .......... .......... .......... .......... 87% 15.0M 1s\n",
      " 59550K .......... .......... .......... .......... .......... 87% 10.3M 1s\n",
      " 59600K .......... .......... .......... .......... .......... 87% 19.9M 1s\n",
      " 59650K .......... .......... .......... .......... .......... 87% 31.8M 1s\n",
      " 59700K .......... .......... .......... .......... .......... 87% 13.9M 1s\n",
      " 59750K .......... .......... .......... .......... .......... 87% 13.6M 1s\n",
      " 59800K .......... .......... .......... .......... .......... 87% 17.2M 1s\n",
      " 59850K .......... .......... .......... .......... .......... 87% 16.6M 1s\n",
      " 59900K .......... .......... .......... .......... .......... 87% 13.4M 1s\n",
      " 59950K .......... .......... .......... .......... .......... 87% 28.9M 1s\n",
      " 60000K .......... .......... .......... .......... .......... 87% 16.5M 1s\n",
      " 60050K .......... .......... .......... .......... .......... 87% 13.5M 1s\n",
      " 60100K .......... .......... .......... .......... .......... 87% 13.0M 1s\n",
      " 60150K .......... .......... .......... .......... .......... 87% 17.5M 1s\n",
      " 60200K .......... .......... .......... .......... .......... 88% 30.3M 1s\n",
      " 60250K .......... .......... .......... .......... .......... 88% 14.5M 1s\n",
      " 60300K .......... .......... .......... .......... .......... 88% 15.1M 1s\n",
      " 60350K .......... .......... .......... .......... .......... 88% 12.8M 1s\n",
      " 60400K .......... .......... .......... .......... .......... 88% 18.4M 1s\n",
      " 60450K .......... .......... .......... .......... .......... 88% 16.3M 1s\n",
      " 60500K .......... .......... .......... .......... .......... 88% 16.4M 1s\n",
      " 60550K .......... .......... .......... .......... .......... 88% 19.1M 1s\n",
      " 60600K .......... .......... .......... .......... .......... 88% 17.8M 1s\n",
      " 60650K .......... .......... .......... .......... .......... 88% 13.6M 1s\n",
      " 60700K .......... .......... .......... .......... .......... 88% 25.2M 1s\n",
      " 60750K .......... .......... .......... .......... .......... 88% 17.5M 1s\n",
      " 60800K .......... .......... .......... .......... .......... 88% 15.0M 1s\n",
      " 60850K .......... .......... .......... .......... .......... 88% 14.5M 1s\n",
      " 60900K .......... .......... .......... .......... .......... 89% 13.7M 1s\n",
      " 60950K .......... .......... .......... .......... .......... 89% 24.9M 1s\n",
      " 61000K .......... .......... .......... .......... .......... 89% 16.4M 1s\n",
      " 61050K .......... .......... .......... .......... .......... 89% 13.8M 1s\n",
      " 61100K .......... .......... .......... .......... .......... 89% 19.1M 1s\n",
      " 61150K .......... .......... .......... .......... .......... 89% 17.3M 1s\n",
      " 61200K .......... .......... .......... .......... .......... 89% 12.5M 1s\n",
      " 61250K .......... .......... .......... .......... .......... 89% 27.9M 1s\n",
      " 61300K .......... .......... .......... .......... .......... 89% 13.4M 1s\n",
      " 61350K .......... .......... .......... .......... .......... 89% 18.0M 1s\n",
      " 61400K .......... .......... .......... .......... .......... 89% 12.1M 1s\n",
      " 61450K .......... .......... .......... .......... .......... 89% 30.3M 1s\n",
      " 61500K .......... .......... .......... .......... .......... 89% 23.4M 1s\n",
      " 61550K .......... .......... .......... .......... .......... 89% 12.1M 1s\n",
      " 61600K .......... .......... .......... .......... .......... 90% 16.8M 1s\n",
      " 61650K .......... .......... .......... .......... .......... 90% 23.6M 1s\n",
      " 61700K .......... .......... .......... .......... .......... 90% 13.5M 1s\n",
      " 61750K .......... .......... .......... .......... .......... 90% 15.6M 1s\n",
      " 61800K .......... .......... .......... .......... .......... 90% 14.2M 1s\n",
      " 61850K .......... .......... .......... .......... .......... 90% 18.3M 1s\n",
      " 61900K .......... .......... .......... .......... .......... 90% 12.8M 0s\n",
      " 61950K .......... .......... .......... .......... .......... 90% 17.1M 0s\n",
      " 62000K .......... .......... .......... .......... .......... 90% 24.4M 0s\n",
      " 62050K .......... .......... .......... .......... .......... 90% 18.5M 0s\n",
      " 62100K .......... .......... .......... .......... .......... 90% 12.4M 0s\n",
      " 62150K .......... .......... .......... .......... .......... 90% 13.5M 0s\n",
      " 62200K .......... .......... .......... .......... .......... 90% 27.2M 0s\n",
      " 62250K .......... .......... .......... .......... .......... 91% 17.8M 0s\n",
      " 62300K .......... .......... .......... .......... .......... 91% 12.3M 0s\n",
      " 62350K .......... .......... .......... .......... .......... 91% 17.3M 0s\n",
      " 62400K .......... .......... .......... .......... .......... 91% 17.0M 0s\n",
      " 62450K .......... .......... .......... .......... .......... 91% 25.6M 0s\n",
      " 62500K .......... .......... .......... .......... .......... 91% 11.8M 0s\n",
      " 62550K .......... .......... .......... .......... .......... 91% 11.2M 0s\n",
      " 62600K .......... .......... .......... .......... .......... 91% 16.1M 0s\n",
      " 62650K .......... .......... .......... .......... .......... 91% 20.0M 0s\n",
      " 62700K .......... .......... .......... .......... .......... 91% 15.4M 0s\n",
      " 62750K .......... .......... .......... .......... .......... 91% 26.1M 0s\n",
      " 62800K .......... .......... .......... .......... .......... 91% 16.2M 0s\n",
      " 62850K .......... .......... .......... .......... .......... 91% 14.9M 0s\n",
      " 62900K .......... .......... .......... .......... .......... 91% 13.6M 0s\n",
      " 62950K .......... .......... .......... .......... .......... 92% 15.7M 0s\n",
      " 63000K .......... .......... .......... .......... .......... 92% 28.8M 0s\n",
      " 63050K .......... .......... .......... .......... .......... 92% 13.2M 0s\n",
      " 63100K .......... .......... .......... .......... .......... 92% 15.5M 0s\n",
      " 63150K .......... .......... .......... .......... .......... 92% 18.1M 0s\n",
      " 63200K .......... .......... .......... .......... .......... 92% 29.0M 0s\n",
      " 63250K .......... .......... .......... .......... .......... 92% 13.7M 0s\n",
      " 63300K .......... .......... .......... .......... .......... 92% 13.2M 0s\n",
      " 63350K .......... .......... .......... .......... .......... 92% 17.2M 0s\n",
      " 63400K .......... .......... .......... .......... .......... 92% 13.0M 0s\n",
      " 63450K .......... .......... .......... .......... .......... 92% 14.1M 0s\n",
      " 63500K .......... .......... .......... .......... .......... 92% 21.3M 0s\n",
      " 63550K .......... .......... .......... .......... .......... 92% 25.8M 0s\n",
      " 63600K .......... .......... .......... .......... .......... 92% 13.3M 0s\n",
      " 63650K .......... .......... .......... .......... .......... 93% 17.8M 0s\n",
      " 63700K .......... .......... .......... .......... .......... 93% 13.4M 0s\n",
      " 63750K .......... .......... .......... .......... .......... 93% 24.8M 0s\n",
      " 63800K .......... .......... .......... .......... .......... 93% 14.2M 0s\n",
      " 63850K .......... .......... .......... .......... .......... 93% 17.6M 0s\n",
      " 63900K .......... .......... .......... .......... .......... 93% 15.5M 0s\n",
      " 63950K .......... .......... .......... .......... .......... 93% 25.7M 0s\n",
      " 64000K .......... .......... .......... .......... .......... 93% 13.5M 0s\n",
      " 64050K .......... .......... .......... .......... .......... 93% 17.8M 0s\n",
      " 64100K .......... .......... .......... .......... .......... 93% 13.2M 0s\n",
      " 64150K .......... .......... .......... .......... .......... 93% 18.7M 0s\n",
      " 64200K .......... .......... .......... .......... .......... 93% 11.5M 0s\n",
      " 64250K .......... .......... .......... .......... .......... 93% 18.4M 0s\n",
      " 64300K .......... .......... .......... .......... .......... 94% 29.5M 0s\n",
      " 64350K .......... .......... .......... .......... .......... 94% 14.6M 0s\n",
      " 64400K .......... .......... .......... .......... .......... 94% 16.8M 0s\n",
      " 64450K .......... .......... .......... .......... .......... 94% 30.5M 0s\n",
      " 64500K .......... .......... .......... .......... .......... 94% 12.5M 0s\n",
      " 64550K .......... .......... .......... .......... .......... 94% 22.0M 0s\n",
      " 64600K .......... .......... .......... .......... .......... 94% 14.2M 0s\n",
      " 64650K .......... .......... .......... .......... .......... 94% 13.8M 0s\n",
      " 64700K .......... .......... .......... .......... .......... 94% 12.8M 0s\n",
      " 64750K .......... .......... .......... .......... .......... 94% 26.2M 0s\n",
      " 64800K .......... .......... .......... .......... .......... 94% 16.6M 0s\n",
      " 64850K .......... .......... .......... .......... .......... 94% 13.2M 0s\n",
      " 64900K .......... .......... .......... .......... .......... 94% 17.5M 0s\n",
      " 64950K .......... .......... .......... .......... .......... 94% 13.0M 0s\n",
      " 65000K .......... .......... .......... .......... .......... 95% 16.8M 0s\n",
      " 65050K .......... .......... .......... .......... .......... 95% 27.0M 0s\n",
      " 65100K .......... .......... .......... .......... .......... 95% 13.7M 0s\n",
      " 65150K .......... .......... .......... .......... .......... 95% 16.3M 0s\n",
      " 65200K .......... .......... .......... .......... .......... 95% 14.9M 0s\n",
      " 65250K .......... .......... .......... .......... .......... 95% 23.1M 0s\n",
      " 65300K .......... .......... .......... .......... .......... 95% 17.3M 0s\n",
      " 65350K .......... .......... .......... .......... .......... 95% 14.2M 0s\n",
      " 65400K .......... .......... .......... .......... .......... 95% 14.8M 0s\n",
      " 65450K .......... .......... .......... .......... .......... 95% 16.6M 0s\n",
      " 65500K .......... .......... .......... .......... .......... 95% 12.6M 0s\n",
      " 65550K .......... .......... .......... .......... .......... 95% 29.0M 0s\n",
      " 65600K .......... .......... .......... .......... .......... 95% 9.95M 0s\n",
      " 65650K .......... .......... .......... .......... .......... 95% 17.5M 0s\n",
      " 65700K .......... .......... .......... .......... .......... 96% 17.9M 0s\n",
      " 65750K .......... .......... .......... .......... .......... 96% 14.9M 0s\n",
      " 65800K .......... .......... .......... .......... .......... 96% 30.1M 0s\n",
      " 65850K .......... .......... .......... .......... .......... 96% 16.2M 0s\n",
      " 65900K .......... .......... .......... .......... .......... 96% 14.2M 0s\n",
      " 65950K .......... .......... .......... .......... .......... 96% 14.0M 0s\n",
      " 66000K .......... .......... .......... .......... .......... 96% 15.8M 0s\n",
      " 66050K .......... .......... .......... .......... .......... 96% 27.4M 0s\n",
      " 66100K .......... .......... .......... .......... .......... 96% 15.1M 0s\n",
      " 66150K .......... .......... .......... .......... .......... 96% 14.0M 0s\n",
      " 66200K .......... .......... .......... .......... .......... 96% 16.9M 0s\n",
      " 66250K .......... .......... .......... .......... .......... 96% 30.4M 0s\n",
      " 66300K .......... .......... .......... .......... .......... 96% 13.2M 0s\n",
      " 66350K .......... .......... .......... .......... .......... 97% 13.9M 0s\n",
      " 66400K .......... .......... .......... .......... .......... 97% 17.3M 0s\n",
      " 66450K .......... .......... .......... .......... .......... 97% 12.9M 0s\n",
      " 66500K .......... .......... .......... .......... .......... 97% 13.3M 0s\n",
      " 66550K .......... .......... .......... .......... .......... 97% 23.4M 0s\n",
      " 66600K .......... .......... .......... .......... .......... 97% 25.9M 0s\n",
      " 66650K .......... .......... .......... .......... .......... 97% 14.9M 0s\n",
      " 66700K .......... .......... .......... .......... .......... 97% 13.6M 0s\n",
      " 66750K .......... .......... .......... .......... .......... 97% 15.4M 0s\n",
      " 66800K .......... .......... .......... .......... .......... 97% 24.9M 0s\n",
      " 66850K .......... .......... .......... .......... .......... 97% 18.7M 0s\n",
      " 66900K .......... .......... .......... .......... .......... 97% 13.7M 0s\n",
      " 66950K .......... .......... .......... .......... .......... 97% 15.4M 0s\n",
      " 67000K .......... .......... .......... .......... .......... 97% 26.6M 0s\n",
      " 67050K .......... .......... .......... .......... .......... 98% 13.3M 0s\n",
      " 67100K .......... .......... .......... .......... .......... 98% 14.6M 0s\n",
      " 67150K .......... .......... .......... .......... .......... 98% 16.1M 0s\n",
      " 67200K .......... .......... .......... .......... .......... 98% 18.2M 0s\n",
      " 67250K .......... .......... .......... .......... .......... 98% 11.0M 0s\n",
      " 67300K .......... .......... .......... .......... .......... 98% 19.7M 0s\n",
      " 67350K .......... .......... .......... .......... .......... 98% 30.6M 0s\n",
      " 67400K .......... .......... .......... .......... .......... 98% 13.8M 0s\n",
      " 67450K .......... .......... .......... .......... .......... 98% 17.4M 0s\n",
      " 67500K .......... .......... .......... .......... .......... 98% 12.2M 0s\n",
      " 67550K .......... .......... .......... .......... .......... 98% 30.2M 0s\n",
      " 67600K .......... .......... .......... .......... .......... 98% 23.3M 0s\n",
      " 67650K .......... .......... .......... .......... .......... 98% 14.3M 0s\n",
      " 67700K .......... .......... .......... .......... .......... 98% 14.0M 0s\n",
      " 67750K .......... .......... .......... .......... .......... 99% 12.8M 0s\n",
      " 67800K .......... .......... .......... .......... .......... 99% 26.6M 0s\n",
      " 67850K .......... .......... .......... .......... .......... 99% 16.9M 0s\n",
      " 67900K .......... .......... .......... .......... .......... 99% 13.6M 0s\n",
      " 67950K .......... .......... .......... .......... .......... 99% 16.3M 0s\n",
      " 68000K .......... .......... .......... .......... .......... 99% 13.0M 0s\n",
      " 68050K .......... .......... .......... .......... .......... 99% 29.8M 0s\n",
      " 68100K .......... .......... .......... .......... .......... 99% 16.6M 0s\n",
      " 68150K .......... .......... .......... .......... .......... 99% 13.3M 0s\n",
      " 68200K .......... .......... .......... .......... .......... 99% 16.1M 0s\n",
      " 68250K .......... .......... .......... .......... .......... 99% 13.5M 0s\n",
      " 68300K .......... .......... .......... .......... .......... 99% 27.3M 0s\n",
      " 68350K .......... .......... .......... .......... .......... 99% 17.4M 0s\n",
      " 68400K .......... .......... .......... .......... .....     100% 12.9M=5.1s\n",
      "\n",
      "2025-03-10 16:52:19 (13.0 MB/s) - ‘./GM12878_250M.bcool’ saved [70088396/70088396]\n",
      "\n"
     ]
    }
   ],
   "source": [
    "%%bash\n",
    "\n",
    "wget https://huggingface.co/rr-ss/Polaris/resolve/main/example/loop_annotation/GM12878_250M.bcool?download=true -O \"./GM12878_250M.bcool\""
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "Polaris provides two methods to generate loop annotations for input `.mcool` file. Both methods ultimately yield consistent loop results."
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Method 1: polaris loop pred\n",
    "\n",
    "This is the simplest approach, allowing you to directly predict loops in a single step.\n",
    "The command below will take approximately 30 seconds, depending on your device, to identify loops in GM12878 data (250M valid read pairs)."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 6,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "polaris loop pred START :)\n",
      "Automatically selected GPU: 0\n",
      "Analysing chroms: ['chr15', 'chr16', 'chr17']\n",
      "\n",
      "********score START********\n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "[Analyzing chr17 with 458 submatrices]: 100%|██████████| 3/3 [00:24<00:00,  8.08s/it]\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "********score FINISHED********\n",
      "********pool START********\n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "[Runing clustering on chr16]: 100%|██████████| 3/3 [00:04<00:00,  1.37s/it]\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "********pool FINISHED********\n",
      "\n",
      "polaris loop pred FINISHED :)\n",
      "2876 loops saved to GM12878_250M_chr151617_loops.bedpe\n"
     ]
    }
   ],
   "source": [
    "%%bash\n",
    "\n",
    "polaris loop pred -c chr15,chr16,chr17 -i GM12878_250M.bcool -o GM12878_250M_chr151617_loops.bedpe -t 0.5"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "> **Note:** If you encounter a `CUDA OUT OF MEMORY` error, please:\n",
    "> - Check your GPU's status and available memory.\n",
    "> - Reduce the --batchsize parameter. (The default value of 128 requires approximately 36GB of CUDA memory. Setting it to 24 will reduce the requirement to less than 10GB.)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Method 2: polaris loop score and polaris loop pool"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "This method involves two steps: generating loop scores for each pixel in the contact map and clustering these scores to call loops.\n"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "**Step 1: Generate Loop Scores**\n",
    "\n",
    "Run the following command to calculate the loop score for each pixel in the input contact map and save the result in `GM12878_250M_chr151617_loop_score.bedpe`."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 7,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "polaris loop score START :) \n",
      "Automatically selected GPU: 0\n",
      "Analysing chroms: ['chr15', 'chr16', 'chr17']\n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "[Analyzing chr17 with 458 submatrices]: 100%|██████████| 3/3 [00:23<00:00,  7.97s/it]\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "polaris loop score FINISHED :)\n",
      "Loopscore file saved at GM12878_250M_chr151617_loop_score.bedpe\n"
     ]
    }
   ],
   "source": [
    "%%bash\n",
    "\n",
    "polaris loop score -c chr15,chr16,chr17 -i GM12878_250M.bcool -o GM12878_250M_chr151617_loop_score.bedpe -t 0.5"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "**Step 2: Call Loops from Loop Candidates**\n",
    "\n",
    "Use the following command to identify loops by clustering from the generated loop score file."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 8,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "polaris loop pool START :) \n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "[Runing clustering on chr15]: 100%|██████████| 3/3 [00:04<00:00,  1.41s/it]\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "polaris loop pool FINISHED :)\n",
      "2876 loops saved to GM12878_250M_chr151617_loops_method2.bedpe\n"
     ]
    }
   ],
   "source": [
    "%%bash\n",
    "\n",
    "polaris loop pool -i GM12878_250M_chr151617_loop_score.bedpe  -o GM12878_250M_chr151617_loops_method2.bedpe -t 0.5"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "We can see both methods ultimately yield consistent loop number.\n",
    "\n",
    "The we can perform [Aggregate Peak Analysis](https://github.com/ai4nucleome/Polaris/blob/master/example/APA/APA.ipynb) to visualize these results."
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "#### ⭐**Little function for very large, high coverage, and hight resolution mcool file**\n",
    "\n",
    "For very large file, the above methods may cause out of memory problem. \n",
    "\n",
    "Therefore, we provide a **Function that under Development**.\n",
    "\n",
    "\n",
    "You can run the code below:"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 9,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Usage: polaris loop scorelf [OPTIONS]\n",
      "\n",
      "  *development* Score Pixels for Very Large mcool (>30GB) ...\n",
      "\n",
      "Options:\n",
      "  -b, --batchsize INTEGER      Batch size [128]\n",
      "  -C, --cpu BOOLEAN            Use CPU [False]\n",
      "  -G, --gpu TEXT               Comma-separated GPU indices [auto select]\n",
      "  -c, --chrom TEXT             Comma separated chroms [all autosomes]\n",
      "  -t, --threshold FLOAT        Loop Score Threshold [0.5]\n",
      "  -s, --sparsity FLOAT         Allowed sparsity of submatrices [0.9]\n",
      "  -md, --max_distance INTEGER  Max distance (bp) between contact pairs\n",
      "                               [3000000]\n",
      "  -r, --resol INTEGER          Resolution [5000]\n",
      "  --raw BOOLEAN                Raw matrix or balanced matrix\n",
      "  -i, --input TEXT             Hi-C contact map path  [required]\n",
      "  -o, --output TEXT            .bedpe file path to save loop candidates\n",
      "                               [required]\n",
      "  --help                       Show this message and exit.\n"
     ]
    }
   ],
   "source": [
    "%%bash\n",
    "\n",
    "polaris loop scorelf --help"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "polaris loop scorelf START :) \n",
      "Automatically selected GPU: 0\n",
      "Analysing chroms: ['chr15', 'chr16', 'chr17']\n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "[Analyzing chr17]: 100%|██████████| 3/3 [00:21<00:00,  7.26s/it]\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "polaris loop scorelf FINISHED :)\n",
      "Loopscore file saved at GM12878_250M_chr151617_loop_score.bedpe\n",
      "\n",
      "polaris loop pool START :) \n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "[Runing clustering on chr16]: 100%|██████████| 3/3 [00:04<00:00,  1.41s/it]\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "polaris loop pool FINISHED :)\n",
      "2876 loops saved to GM12878_250M_chr151617_loops_method2.bedpe\n"
     ]
    }
   ],
   "source": [
    "%%bash\n",
    "\n",
    "polaris loop scorelf -c chr15,chr16,chr17 -i GM12878_250M.bcool -o GM12878_250M_chr151617_loop_score.bedpe -t 0.5\n",
    "polaris loop pool -i GM12878_250M_chr151617_loop_score.bedpe  -o GM12878_250M_chr151617_loops_method2.bedpe -t 0.5\n"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": []
  }
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