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43,254,821 | {
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} | Recent studies indicate that the circadian pacemakers in the eyes of Japanese quail are coupled to the rest of the circadian system by both neural and hormonal outputs. The effects of exogenous melatonin administration on cir cadian body temperature and activity rhythms of quail were tested to determine whether melatonin could be the hormonal link involved. Continuous melatonin administration caused arrhythmicity or period changes in the body temperature and activity rhythms of pinealectomized and sham-pinealectomized birds held in constant darkness and also significantly decreased the amplitude of the body temperature rhythms of normal birds held on light:dark 12:12. Further, mela tonin entrained the body temperature and activity rhythms of normal birds when administered daily via the drinking water. The results show that melatonin can affect the circadian system of quail and support the hypothesis that melatonin is importantly involved in linking pacemakers in the eyes to the rest of the circadian system. | 2022-09-14T12:53:46.804Z |
6,927,283 | {
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"DOI": "10.4049/jimmunol.164.10.5094",
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} | As a potential means for facilitating studies of NK cell-related molecules, we examined the expression of these molecules on a range of mouse tumor cell lines. Of the lines we initially examined, only EL4 and RMA expressed such molecules, both lines expressing several members of the Ly49 and NKRP1 families. Unexpectedly, several of the NK-related molecules, together with certain other molecules including CD2, CD3, CD4, CD32, and CD44, were often expressed in a mosaic manner, even on freshly derived clones, indicating frequent switching in expression. In each case examined, switching was controlled at the mRNA level, with expression of CD3ζ determining expression of the entire CD3-TCR complex. Each of the variable molecules was expressed independently, with the exception that CD3 was restricted to cells that also expressed CD2. Treatment with drugs that affect DNA methylation and histone acetylation could augment the expression of at least some of the variable molecules. The striking phenotypic similarity between EL4 and RMA led us to examine the state of their TCRβ genes. Both lines had identical rearrangements on both chromosomes, indicating that RMA is in fact a subline of EL4. Overall, these findings suggest that EL4 is an NK-T cell tumor that may have retained a genetic mechanism that permits the variable expression of a restricted group of molecules involved in recognition and signaling. | 2022-09-16T05:05:41.219Z |
245,721,236 | {
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"url": "https://www.revistas.usp.br/estic/article/download/182382/178492"
} | Este artigo tem como objetivo traçar um panorama acerca dos lugares de vulnerabilidade que as crianças têm ocupado nos cenários da pólis e identificar possíveis modos de cuidados para com elas. Trata-se de uma reflexão teórica que problematiza a maneira como as dinâmicas sociais interferem na constituição subjetiva dos sujeitos. Foram retomados alguns conceitos fundamentais para Freud, como o desamparo e o mal-estar civilizatório, refletindo sobre como estes se presentificam na formação dos laços sociais na conjuntura contemporânea das infâncias. Coube, ainda, enfatizar o processo de segregação e a desigualdade social que compõem a construção das cidades no Brasil, colocando em cena a situação das crianças nestes cenários. Finalmente, considerou-se as possibilidades de cuidado à infância, interessando à psicanálise o sujeito do inconsciente e a circulação da palavra. | 2022-01-22T01:50:03.402Z |
15,658,738 | {
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} | With the increasing of comment data about television programs on Internet, using text mining technology to analyze the massive data so that it can make subjective evaluation about television programs. It can give decision support and improve competitiveness for each department in radio and TV industry. This paper mainly introduces how to using sentiment-oriented pointwise mutual information (SO-PMI) to judge sentimental words' polarity and calculate sentimental words' intensity. It lays a solid foundation for the further study of subjective evaluation about television programs. | 2022-11-28T18:00:46.337Z |
28,355,637 | {
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} | A 9-year-old girl was admitted to our hospital with juvenile metachromatic leukodystrophy (arylsulfatase A deficiency). Symptoms of this lysosomal storage disease, such as decreased school performance and compromised motor skills, had started 1 year earlier. She underwent bone marrow transplantation from a matched unrelated donor after receiving conditioning with fludarabine, treosulfan, and thiotepa, together with thymoglobulin, a rabbit antithymocyte globulin. Conditioning was well tolerated, and the posttransplantation period was uneventful except for 1 febrile episode. Graft-vs-host disease (GvHD)4 prophylaxis consisted of 3 methotrexate doses in combination with a starting daily cyclosporin A (CsA) dosage of 3 mg · kg−1 · day−1. Trough CsA concentrations were monitored with the antibody-conjugated magnetic immunoassay (ACMIA) for CsA (RxL Dimension; Siemens). CsA concentrations entered the therapeutic interval after 3 days, and the dosage was adjusted to achieve trough concentrations of 120–150 μg/L (Fig. 1). The patient received CsA for 16 weeks. During this period, the CsA concentration was measured 31 times, with results from 98 μg/L to 219 μg/L (mean, 156 μg/L). Four weeks after transplantation, the patient developed a mild GvHD of the skin, which disappeared immediately after commencement of prednisolone treatment. Because B lymphocytes were absent or low early after transplantation, the patient received immunoglobulins for 5 months (Fig. 1). Endogenous immunoglobulin production started only in the later phase of immune reconstitution. Six weeks after discontinuation of CsA therapy, a concentration of 147 μg/L was still detected in whole blood. Although the patient was not supposed to have received CsA and the parents had denied the administration of CsA or drugs other than those prescribed, CsA concentrations between 116 μg/L and 174 μg/L were obtained over the next 4 months.
Fig. 1. Time courses of the whole-blood CsA concentration measured with the ACMIA CsA assay, the administered daily CsA dose, and the B-lymphocyte count.
### QUESTIONS TO CONSIDER
1. Has the CsA therapy really been discontinued?
2. Can delayed drug elimination explain the continued increased CsA concentrations?
3. What … | 2022-12-07T22:42:48.417Z |
235,961,171 | {
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} | In the patients with stenotic upper respiratory airways tumor, the tracheal intubation during the surgical resection is sometimes impossible. In these situations, Extracorporeal Membrane Oxygenation appears to be an interesting temporarily alternative to ventilation to allow tumor removal. In this report the authors describe a case of successful resection of tracheal tumor in an 80-year-old female patient in which tracheal intubation was impossible. A circulatory assistance was used to perform the operation. Afterwards, tracheal intubation was easily performed for the rest of the operation. | 2022-12-11T11:27:27.610Z |
16,591,697 | {
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"DOI": "10.1145/2893180",
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} | Considering the role of universities in promoting tolerance as well as education. | 2022-12-13T10:40:55.659Z |
33,946,003 | {
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} | To obtain a comprehensive understanding of proteins involved in excitation–contraction coupling, a catalog of proteins from sarcoplasmic reticulum (SR) membrane fractions of New Zealand white rabbit skeletal muscle was analyzed by an optimized shotgun proteomic method. Light and heavy SR membrane fractions were obtained by nonlinear sucrose gradient centrifugation and separated by 1DE followed by a highly reproducible, automated LC‐MS/MS on the hybrid linear ion trap (LTQ) Orbitrap mass spectrometer. By integrating as low as 1% false discovery rate as one of the features for quality control method, 483 proteins were identified from both of the two independent SR preparations. Proteins involved in calcium release unit complex, including ryanodine receptor 1, dihydropyridine receptor, calmodulin, triadin, junctin, and calsequestrin, were all detected, which offered validation for this protein identification method. Rigorous bioinformatics analysis was performed. Protein pI value, molecular weight range, hydrophobicity index, and transmembrane region were calculated using bioinformatics softwares. Eighty‐three proteins were classified as hydrophobic proteins and 175 proteins were recognized as membrane proteins. Based on the proteomic analysis results, we found as the first time that not only transverse tubule but also mitochondrion physically connected to SR. The complete mapping of these proteomes may help in the elucidation of the process of excitation–contraction coupling and excitation–metabolism coupling. | 2022-12-18T10:16:45.949Z |
204,726,721 | {
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"DOI": "10.1080/17400309.2019.1665244",
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} | After its launch in 2005, the American cable channel Logo TV produced a slate of original programs featuring explicit representations of its targeted LGBTQ audience base. By 2012, however, the chan... | 2022-12-18T21:33:01.863Z |
199,608,078 | {
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} | [1] CREUTZFELDT, H. G., "Zur Anatomie aind Lokalization der Spatencephalitis," Zeit. f. Neir. Heilkunde, 1924, lxxxi, p. 110. [2] STRAUSS, I., and GLOBUS, J. H., " A Contribution to the Neuropathology of the Parkinsonian Syndrome follouwing Epidemic Encephalitis," Arch. Neur. and Psych,. 1923, x, p. 597. [3] MCKINLEY, J. C., and GOWAN, L. R., " Neuron Destruction in Postencephalitic Paralysis Agitans," Arch. Neur. and Psych., 1926, p. 151. [4] SPATZ, H., "Die Snbstantia nigra and das extra-pyramidal motorische System," Deutsche Zeitschr. f. Nervenheilk., 1923, lxxvii, p. 275. [5] HOHMIAN, L., " Pathlologisch-anatornische Uiitersachtingen iiber den encephalitischen Parkinsonismus," Arch. a. d. Neurol. Inst. Wiener Univers., 1925, p. 27. [6] Foix, CH., and NICOLESCO, I., Anatomie cerebrale noyaiux gris centraux et region miesencephalo-sous-optique," Paris, 1925. [7] TAROZzi, G., " Reperto anatomo-istologico in an caso di sindrome di Parkinsoin postencefalitica," Rev. Sperimient. di Frenat., 1923, xlvii, p. 3. [8] VEGNI, R., " Studio Anatomico-clinico di uii caso di encefalite epidernica cronica a sindrome Parkinsoniana," II Policlin. (Sez. Med.), 1923, xxx, p. 195. [9] JACOB, A., " Die extrapyramidalen Erkrankungen," Berliln, 1923. [10] Lkvy, G., " Les manifestations tardives de l'encephalite 6pid6mique," Paris, 1924. [11] HASsIN, G. B., and BASSOE, P., " Parkinsonian States," Arch. Neatr. and Psych., 1926, xv, p. 218. F12] MIRTO, " Contributo alla fina anatomia della suibstantia niigra di Soemmering," Biv. Sper. di Frenatica, 1896. [13] KAPPERS, A., "Vergleichende Anatomie cles Nervensystems," Haarlem, 1921, ii. [14] DRESEL, K., and ROTHMANN, H., "Violliger Ausfall der Suibstantia nigra nach Extirpation von Groshirn ulld Striatu-m," Zeitschr. f. d. ges. Aeaur. u. Psych., 1924, xcv, p. 781. [15] FERRARO, A., " Contribhito sperimentale allo studio della siibstantia nigra n1ormales," Arch. Gemn. di Neur. Psich. e Psico, 1925, vi, p. 26. [16] VOGT, C. and O., " Zur Lehre der Erkrankungen des strikren Systems," Jour. f. Psych. nI. Neutrol., 1920, xxv (Ergiinziingsheft 3), pp. 627846. [17] WILSON, S. A. K., "An Experimental Research into the Anatomy and Physiology of the Corpus Striatum," Brain, 1914, xxxvi, p. 427. [18] DEJERINE, J., " Anatomie des ceintres lierveux1" Paris, 1895. [19] McALPINE, D., " The Pathology of the Parkinsonian Syndrome," Brain, 1923, xlvi, p. 255. [20] HURST, F. W., " On the So-called Calcification in the Basal Ganglia of the Brain," Journ. of Path. and Bact., 1926, xxxix, p. 65. [21] TRETIAKOFF, C., "Contribution h l'6tude de l'anatomie pathologique du locus niger," Thise de Paris, 1919. r22] LHERMITTE, J., "Les syndromes anatomocliniqaies du corps strie chez le vieillard," Rev. Neatr. 1922, xxix, p. 406. | 2022-12-23T02:13:21.897Z |
227,013,380 | {
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"DOI": "10.3760/CMA.J.ISSN.1674-1927.2014.02.011",
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} | Objective To investigate the association of renal function and inflammatory cytokines with left ventricular hypertrophy (LVH) in patients with intermediate or advanced stage chronic kidney disease (CKD).Methods Fifty-one hospitalized or clinic patients with intermediate or advanced stage CKD registered to our hospital between January 2009 and December 2012 were enrolled.Clinical and biochemical data of these patients were recorded.Left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) of these patients were measured with ultrasonography and used for calculation of left ventricular mass index (LVMI).The patients were then divided into stage Ⅲ CKD group or stage Ⅳ CKD group according to glomerular filtration rate (GFR),and also into LVH group and non-LVH group according to presence of LVH.Clinical and biochemical data,as well as findings of ultrasonography were compared between these groups.The correlation between GFR and the clinical and biochemical data,ultrasonic findings were analyzed.Results Of all 51 CKD patients,32 were stage Ⅲ CKD,and 19 stage Ⅳ CKD.There were no statistical difference in serum C-reactive protein (CRP),fibrinogen and albumin between patients with stage Ⅲ and stage Ⅳ CKD (all P＞0.05).A total of 40 patients had LVH and the remaining 11 did not.Compared with non-LVH group,patients in LVH group had higher levels of serum CRP and fibrinogen,and lower level of serum albumin (all P ＜ 0.05).In intermediate or advanced stage CKD patients,GFR correlated positively with LVEF and LVFS (r=0.398 and 0.394,respectively,both P ＜ 0.05).Conclusions In patients with intermediate or advanced CKD,higher levels of serum CRP and fibrinogen may predict the occurrence of LVH.The renal function in those patients is associated with left ventricular systolic function.
Key words:
Kidney diseases; Glomerular filtration rate; Inflammation; Hypertrophy, left ventricular | 2022-02-07T23:38:22.589Z |
216,254,907 | {
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"DOI": "10.25009/ej.v0i1.2530",
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"url": "https://enfoquesjuridicos.uv.mx/index.php/letrasjuridicas/article/download/2530/pdf"
} | RESUMEN: La película “moolaadé” expone prácticas ancestrales que han dado título a este trabajo, en cuanto refleja la invisibilidad de este tipo de violencia (mutilación genital femenina) que forma parte de un atavismo tribal. La situación permite numerosos enfoques que, naturalmente, remiten a otros aspectos que conforman las reivindicaciones tuitivas de la mujer en la actualidad. En este sentido, no podemos dejar de puntualizar el mensaje que transmite el documental, que una vez más revela el complejo tránsito sobre el alcance de la universalidad de estos derechos que, sin duda y respetando cada grupo cultural, debieran constituir un paradigma común.Palabras clave: violencia, tradición, género, etnia, reivindicación.ABSTRACT: The film “moolaadé” shows ancestral practices as regards the invisibility of this type of violence (female genital mutilation) that forms part of a tribal atavism. This situation described in the movie allows us to get numerous approaches which are –unavoidably- involved with other constitutive aspects of women´s claims today. Along these lines, we underline the message given by the film that reveals the complex transit on the universality of women´s rights, whose bases should be made up by a common paradigm respecting each cultural group.Keywords: violence, tradition, gender, ethnicity, claim. | 2022-06-30T07:20:24.662Z |
221,605,595 | {
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"DOI": "10.1002/cyto.a.23041",
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} | Whole Blood goes in, Leukocytes come out Today’s methods for flow cytometric sample preparation are generally laborious multi-step protocols which use aggressive buffers that are either toxic or cause hypotonic stress to fragile cells (or both) and can result in as much as 50% cell loss. Civin and co-workers demonstrate for the first time using a commercially viable polymeric chip incorporating Deterministic Lateral Displacement (DLD) to gently and uniformly remove >99.98% of erythrocytes, while simultaneously recovering a washed leukocyte preparation free from populational bias and leaving antibody staining and scatter profiles largely unchanged as compared to chemically lysed samples. This novel approach eliminates numerous hands-on steps and greatly simplifies workflows, and indicate that cost-effective plastic DLD microchips can speed and automate leukocyte processing for high quality flow cytometry analysis, and suggest their utility for multiple other applications. | 2022-08-20T10:50:28.972Z |
146,563,469 | {
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"DOI": "10.1504/ijbg.2015.072535",
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} | This article carries out an integrative analysis of internationalisation theories. The most important contributions to the literature on internationalisation theories are used to create a schematic table giving a framework overview. This approach shows the high-level interaction of the literature, covering all internationalisation theories, their focus and basic assumptions, while at the same time showing their historical timeline. We identify the main schools of thought - ranging from economics based to integrative models - using an analysis that begins in the 18th century and ends in the 21st century with the most recent trends in internationalisation theories. This schematic and integrative analysis aims to support the academic community in their research on business internationalisation. | 2022-12-16T18:17:04.895Z |
125,215,000 | {
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"DOI": "10.2514/6.2018-2048",
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} | Fast-response Pressure-Sensitive Paint (PSP) was used to study the wake response of the hemispherical turret at different subsonic and transonic Mach numbers to different pressure patterns on the hemisphere itself. POD technique was used to extract dominant spatial modes and the corresponding temporal coefficients of the unsteady pressure field on the hemisphere. The unsteady pressure distributions in the wake for different conditional events, such as large positive or negative temporal coefficients for different hemisphere-only POD modes, were computed and analyzed. It was found that the wake has the two main dynamic modes, the “switching” and “breathing” ones. The wake dynamics was found to be coupled with the instantaneous location of the separation line on the hemisphere. In the range of tested Mach numbers, the presence of the unsteady shock on the hemisphere did not have any significant effect of the wake dynamics. | 2022-12-16T23:38:00.713Z |
248,329,115 | {
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"DOI": "10.3390/s22093167",
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"url": "https://www.mdpi.com/1424-8220/22/9/3167/pdf?version=1650507188"
} | Dynamic displacement plays an essential role in structural health monitoring. To overcome the shortcomings of displacement measured directly, such as installation difficulty of monitoring devices, this paper proposes a smart reconstruction method, which can realize real-time intelligent online reconstruction of structural displacement. Unlike the existing approaches, the proposed algorithm combines the improved mode superposition methods that is suitable for complex beam structures with the Kalman filtering approach using acceleration and strain data. The effectiveness of the proposed multi-rate data fusion method for dynamic displacement reconstruction is demonstrated by both numerical simulation and model vibration experiment. Parametric analysis shows that the reconstruction error is only 5% when the noise signal to noise ratio is 5 dB, illustrating that the proposed algorithm has excellent anti-noise performance. The results also indicate that both the high-frequency and low-frequency components of the dynamic displacements can be accurately reconstructed through the proposed method, which has good robustness. | 2022-12-17T05:42:48.966Z |
4,002,267 | {
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} | A colocated multiple-input multiple-output (MIMO) radar system has the ability to address multiple beam information. However, the simultaneous multibeam working mode has two finite working resources: the number of beams and the total transmit power of the multiple beams. In this scenario, a resource allocation strategy for the multibeam working mode with the task of tracking multiple targets is developed in this paper. The basis of our technique is to adjust the number of beams and their directions and the transmit power of each beam through feedback, with the purpose of improving the worst tracking performance among the multiple targets. The Bayesian Cramér-Rao lower bound (BCRLB) provides us with a lower bound on the estimated mean square error (MSE) of the target state. Hence, it is derived and utilized as an optimization criterion for the resource allocation scheme. We prove that the resulting resource optimization problem is nonconvex but can be reformulated as a set of convex problems. Therefore, optimal solutions can be obtained easily, which greatly aids real-time resource management. Numerical results show that the worst case tracking accuracy can be efficiently improved by the proposed simultaneous multibeam resource allocation (SMRA) algorithm. | 2022-12-20T03:02:49.937Z |
40,425,998 | {
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} | We used representational difference analysis to discover new genes with specific expression in dendritic cells. Among other genes, we identified HEP27, encoding a member of the short chain alcohol dehydrogenase/reductase family to be upregulated during monocyte to dendritic cell differentiation. Originally cloned from hepatocellular carcinoma cells (HepG2), HEP27 was exclusively expressed in monocyte-derived dendritic cells within the hematopoietic system. The presence of different transcripts in monocyte-derived dendritic cells, HepG2 cells, and various tissues could be traced back to alternative splicing and alternative promoter usage. We describe here the complete genomic organization of HEP27, including two alternative promoter regions: a hepatocyte-specific promoter which was induced by the histone deacetylase inhibitor sodium butyrate in several other cell types, and a second upstream promoter which was specifically active in monocyte-derived dendritic cells. Its exclusive usage in monocyte-derived dendritic cells makes the alternative HEP27 promoter an interesting target to study dendritic-cell-specific gene regulation. | 2023-01-01T17:40:52.307Z |
76,139,691 | {
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} | Changes in coagulation findings before and after development of acute myocardial infarction and stroke were determined in patients who admitted in Tokyo Metropolitan Geriatric Hospital. The patients were restricted to autopsied cases in whom coagulation analysis was carried out within 24 hours following the attack of acute myocardial infarction or apoplexy. These cases consisted of 28 of acute myocardial infarction, 28 of acute cerebral infarction (excluding cases of hemorrhagic infarction), 7 of acute cerebral hemorrhagic infarction and 10 of acute cerebral hemorrhage. There were no changes in APTT and prothrombin time before and after the onset of the myocardial infarction or the stroke. A slight increase in plasma fibrinogen content was occasionally observed before the attack of the myocardial infarction or the apoplexy, however levels of fibrinogen in plasma tended to increase markedly following the attack. A slight increase in FDP was frequently observed in patients with poor prognosis. A remarkable prolongation of euglobulin lysis time was observed in cases of acute myocardial infarction. Euglobulin lysis times were prolonged in these cases preceding the development of the infarction. Generally, euglobulin lysis times in cases of acute cerebral hemorrhage or acute cerebral hemorrhagic infarction were slightly shorter than in cases of acute cerebral infarction (excluding hemorrhagic infarction). There was a trend toward a transient shortening of euglobulin lysis time after the attack of stroke, followed by a marked prolongation accompanied with a decrease in plasminogen content in plasma. A decrease in levels of antithrombin III in plasma was ob- | 2022-02-11T06:42:28.964Z |
129,032,719 | {
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} | With reference to data in a paper by T. P. Crimes and N. B. Dhonau on the Precambrian and lower Paleozoic of Wexford (for reference, see this Bibliography Vol. 32, No. 5, 20 E68-05581), it is pointed out that migmatites of the Rosslare complex exhibit certain similarities with Malvernian gneisses of the Malvern hills (England), but that neither of these complexes is in any way similar to Lewisian complexes. | 2022-05-05T16:05:24.991Z |
220,343,240 | {
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"DOI": "10.1177/105381518100400112",
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} | Most ERIC documents are available from the ERIC Document Reproduction Service (EDRS), P.O. Box 190, Arlington, Virginia 22210. Documents may generally be ordered either in a printed format, referred to as paper copy (PC) or on microfiche (MF), which is a 4 inch by 6 inch sheet of microfilm containing up to 96 pages of text. In ordering documents from EDRS, specify the desired format (PC or MF) and the ED identifying number. | 2022-07-10T04:47:55.066Z |
250,881,395 | {
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"DOI": "10.1088/0957-0233/3/4/017",
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} | A simple method of calculating the out-of-plane deflection of an object under a static load using a split lens speckle shearing interferometry is described. Experimental data of an optical shearogram have been analysed by this technique which appears to be satisfactory. | 2022-07-31T09:03:48.357Z |
157,055,534 | {
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"url": "https://ecoprom.misis.ru/jour/article/download/160/153"
} | The successful development of integration processes that improve the efficiency of national economies in the contemporary context of globalization seems appropriate to the creation of financial-industrial groups (FIG). The article is devoted to educational issues and the functioning of FIG, with the participation of enterprises ofAzerbaijanRepublicandRussian Federation. Factors prioritize the creation of such FIG; proposed principles of the strategy FIG outlines the key directions for the design of FIG; proposed priority activities for the successful implementation of FIGAzerbaijanandRussia. | 2022-09-02T03:36:15.532Z |
54,487,142 | {
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"DOI": "10.1109/EMBC.2016.7591805",
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} | This paper presents an elastic ribbon-like piezoelectric energy harvester which is targeted for skin-wearable devices by harnessing the movements of stretchable surfaces. The device aims to power up smart thin stick-on devices for healthcare monitoring. By embedding a ribbon-like PVDF film in a flexible elastomer, Ecoflex, the device is potentially able to stretch 34%, while maintaining internal strain of the film below its plastic deformation limit. Alternate electrode layout and bimorph configuration help to reduce charge cancellation, while increasing overall effectiveness. The harvester prototype with 225 mm3 active volume is able to output 15.6 V at open-circuit upon stretching 26% and is capable of generating at least 121 nJ per cycle. | 2022-09-15T07:06:13.890Z |
20,585,834 | {
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} | The separation of chyle lipoproteins on columns of hydroxyl apatite has been studied using phosphate buffer pH 6.9 of increasing molarity as eluent. Results obtained with lipoprotein fractions of different densities, isolated by centrifugation, indicate that 0.7 M buffer elutes lipoproteins with a density corresponding to Sf < 1,000. Lipoproteins with Sf < 1,000 cannot be eluted from the column, their lipids, however, can be recovered by eluting with chloroform/methanol. The lymph cholesterol of dietary origin is present to a larger extent in smaller size lipoprotein particles than the triglyceride fatty acids of the same origin | 2022-09-15T01:37:43.869Z |
148,574,686 | {
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"DOI": "10.1109/ISIVC.2018.8709192",
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} | This paper presents a novel method to detect unusual crowd behavior in a video sequence using probability models of speeds and directions. Thus, optical flow is used to extract velocities at each image frame, which are then reduced to speed and motion orientations. Using expectation maximization algorithm, we construct a mixture model of von Mises distribution describing the set of directions, and a mixture model of normal distribution related to the speed set. Each frame is compared with a collection of reference frames using distance of probability densities. This distance is then used to indicate changes in the crowd motion. Unlike the speed based detection, using the direction model is not yet adapted to the case of unstructured crowds. The proposed method was tested on various publicly available crowd datasets. | 2022-11-09T19:00:01.332Z |
128,902,043 | {
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} | On Contemporary Ice streams the most important factor controlling polar ice-sheet sheet stability and ice flowing occurs in ice streams. On Pleistocene Ice Sheet, Ice stream can be located using several geomorphologic criteria predict from known characteristic of contemporary ice streams, these criteria defining the conceptual Ice Stream land system model. But nowadays, during fossil glaciations, ice streams characterization is still poorly documented and only few studies illustrate fast ice velocity. In this work, we characterize geomorphological markers of ice stream activity in order to define the Ordovician ice stream glacial landsystem. The study area is located in Sahara from Niger to Algeria. In this area, Ordovician glacial landforms have been investigated using satellite images and field investigations. According to these observations, Ordovician paleo ice stream are characterize by their size (20 to 200 km), by the increase of the length or ratio L/l of sub-glacial lineations changing from ice flute to mega scale glacial lineation at the margin of the ice sheet, by the evolution of sub glacial valley morphology ranging from areal scouring to glacial linear incision, and by sub glacial deformation. Finally, marine outlet of ice stream show ice contact deltas deposit. Individually, these criteria may not necessarily be exclusive to ice stream activity, but collectively they are thought to discriminate the characteristic Ordovician ice stream landsystem. | 2022-12-13T06:19:57.460Z |
21,978,304 | {
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"url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC270505"
} | Dot and Northern (RNA) blot hybridization assays were developed for the P typing of group A bovine rotaviruses (BRV) by using cDNA probes prepared from gene segment 4. The probes were prepared by polymerase chain reaction amplification of hyperdivergent regions (nucleotides 211 to 686) of BRV strain UK, IND, NCDV, and Cr VP4 cDNA by using specific oligonucleotide primers. The probes were P type specific (VP4) and exhibited little or no cross-reactivity with double-stranded RNA from heterologous rotavirus P types. Our studies indicate that at least three P types, as defined by polymerase chain reaction-derived VP4 gene probes from the UK, NCDV, and Cr strains, exist among the seven BRV isolates tested. | 2022-12-17T00:09:11.467Z |
222,957,640 | {
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} | 一、病例摘要病例1(Ⅱ:8,图1):女性,55岁,汉族,因“左腰酸14年,右甲状旁腺切除术后近3年,血钙升高1个月”于2009年8月入院.患者于14年前因左侧腰部酸痛就诊,发现左肾结石,未予特殊治疗,增加饮水后症状仍反复出现;3年前无明显诱因下出现乏力,双膝关节酸痛不适,体重下降10余斤,至外院查骨密度示骨质疏松,血钙3.22 mmol/L(正常参考范围2.08 ～2.60,下同)、血PTH 76.4 pg/ml( 15～65),B超示双侧甲状腺下极后下方低回声肿块,甲状旁腺肿瘤可能,左肾结石;CT示右侧甲状腺后缘低密度影,甲状旁腺腺瘤可能性大;于2006年11月8日在外院行右甲状旁腺切除术,左甲状腺结节摘除术。 | 2022-02-08T00:43:38.528Z |
253,503,605 | {
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"DOI": "10.34117/bjdv8n11-034",
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} | A adição de ti em aço inoxidável ferrítico possui efeito benéfico no refino de grão e propicia melhoria na resistência à corrosão. O efeito da incorporação de 0,4 e 0,6% de Ti na liga Fe-25Cr foi investigado através de técnicas de microscopia, ensaio de imersão com variação de temperatura e ensaio eletroquímico. Os resultados indicam maior refino de grão na concentração de 0,4% de Ti, além disso foi observado que o titânio possui papel importante na melhoria da resistência à corrosão por frestas e por pites. | 2022-11-14T17:31:50.001Z |
15,433,505 | {
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"DOI": "10.1093/OXFORDJOURNALS.SCHBUL.A033492",
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} | We studied schizophrenia spectrum disorders in Chernobyl accident survivors by analyzing Chernobyl exclusion zone (EZ) archives (1986-1997) and by conducting a psychophysiological examination of 100 patients with acute radiation sickness (ARS) and 100 workers of the Chernobyl EZ who had worked as "liquidators-volunteers" for 5 or more years since 1986-1987. Beginning in 1990, there has been a significant increase in the incidence of schizophrenia in EZ personnel in comparison to the general population (5.4 per 10,000 in the EZ versus 1.1 per 10,000 in the Ukraine in 1990). Those irradiated by moderate to high doses (more than 0.30 Sv or 30 rem), including ARS patients, had significantly more left frontotemporal limbic and schizophreniform syndromes. We hypothesized that ionizing radiation may be an environmental trigger that can actualize a predisposition to schizophrenia or indeed cause schizophrenia-like disorders. The development of schizophrenia spectrum disorders in overirradiated Chernobyl survivors may be due to radiation-induced left frontotemporal limbic dysfunction, which may be the neurophysiological basis of schizophrenia-like symptoms. Persons exposed to 0.30 Sv or more are at higher risk of schizophrenia spectrum disorders. An integration of international efforts to discuss and organize collaborative studies in this field is of great importance for both clinical medicine and neuroscience. | 2022-12-20T02:12:11.604Z |
109,146,334 | {
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"DOI": "10.1115/GT2008-51233",
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} | Oil-free pressurized air is needed in several industrial fields, i.e. paper mills and in electronics manufacturing. The pressure level is rather high, 600 – 900 kPa, and the compressor type usually used in these applications are dry screw compressors and gearbox-driven centrifugal compressors. However, drawbacks of these kinds of compressors are wearing of the components, high maintenance costs and increased energy consumptions during the life-time. To tackle these drawbacks, the prototype of a two-stage centrifugal compressor was designed, manufactured and tested. Both compressor impellers and the electric motor are on the same shaft, and magnetic bearings are used to make the machine oil-free. Due to the high pressure level and two compressor stages, the centrifugal compressor needs to run at relatively high rotation speed. When the compressor has more than one wheel, the compressor power can be reduced and the overall efficiency increased with intercooling. In a two-stage compressor this means that the pressurized air after the first stage is cooled near to ambient temperature. As a result the compressor consumes less power, but intercooling causes a pressure loss to the system, which has to be taken into account. The compromise is needed with the same mass flow rate compressor stages is very restrictive, as the specific speeds can not vary much. The main difference comes from the different volume flows, as the density in the second stage is higher than in the first stage. The final optimizing of the efficiency takes into account the mechanical requirements with shaft critical speeds. The operation of the two-stage air compressor driven by a high-speed motor is rated at the point 800 kPa(g), 0.9 kgs−1 , 300 kW and 60 000 rpm, respectively. The compressor stages are equipped with vaneless diffusers to maximize the operational range. The aerodynamic design based on the traditional in-house practice is verified with computerized flow dynamics using the Finflo-solver. The calculation does not include the volute, and the differences between the CFD results and the in-house design results are larger in the first stage of the compressor. Both compressor stages have been properly measured in a comprehensive test program following the measurement standards. The performances of the compressor stages at 80% speed are similar to the design data. At design speed both the efficiencies and pressures are lower than expected and the results indicate a need to improve the aerodynamic design.Copyright © 2008 by ASME | 2022-02-10T06:37:20.522Z |
252,822,974 | {
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"DOI": "10.15554/pci.cta-18",
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},
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"status": "BRONZE",
"url": "https://doi.org/10.15554/pci.cta-18"
} | Develops a rational design method for the tube-in-tube column-corbel connection modifying the PCI Design Handbook concept. Presents experimental verification. | 2022-10-14T00:55:22.216Z |
109,089,348 | {
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"DOI": "10.1080/13632469.2014.974291",
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} | Shake table tests were carried out on a 7 m × 5 m three-story, timber light-frame building (7.5 m height) at the TreesLab laboratory (Eucentre) in Pavia. The aim of the research was to evaluate the seismic behavior of a typical Italian prefabricated timber building and to study the interaction between the individual structural components tested in quasi-static manner in a previous experimental study. The 1979 Montenegro Earthquake ground motion, recorded at the Ulcinj-Hotel Albatros station, was selected as the ground motion for seismic tests. The maximum peak ground acceleration was scaled to 0.07 g, 0.27 g, 0.5 g. 0.7 g, and 1 g in order to evaluate the building’s performance at different levels of seismic input. More than 100 instruments were used to monitor the behavior of the building during seismic tests measuring acceleration, displacement, and forces. The visual inspection shows that the building did not show any damage during all seismic tests. However the data analysis (dynamic identification, capacity spectrum, inter-story drift) confirm that during the 1.00 g test the structure went beyond its linear elastic limit. The results obtained from this experimental study suggest that the design hypotheses commonly adopted in practice for seismic analysis (e.g., in terms of force distributions between the walls, and also the behavior factor q) are not always consistent with the real behavior of timber frame multi-story buildings, and should be backed by more accurate knowledge of the contributions of the individual structural components. | 2022-11-19T16:35:00.500Z |
21,816,819 | {
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"DOI": "10.1093/OXFORDJOURNALS.JBCHEM.A132353",
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} | The pH-dependence of the kinetic parameters in H2O2 decomposition by beef liver catalase was investigated. At pH 7.0, the ternary complex (ESS) decomposition rate was about 100 times faster than ESS formation (42 microM H2O2), and the value of the Michaelis constant was 0.025 M. From ethanol competition experiments, two different proton dissociation constants of the enzyme (pKe1 = 5.0, pKes2 = 5.9) were obtained for the binding of first and second H2O2 molecules. Another pKa value (pKes1) of 4.2 was obtained from the pH dependence of overall rate constant (ko). The reaction mechanism of catalase was discussed in relation to these ionizable groups. | 2022-12-14T09:46:55.040Z |
17,769,435 | {
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"DOI": "10.1080/02643290342000131",
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"status": "GREEN",
"url": "http://www.cse.ucsd.edu/classes/fa07/cse87-b/papers/stricker/harely2004CNPFuture.pdf"
} | Reflections stimulated by Rapp, B. (Ed.) (2001). ‘The handbook of cognitive neuropsychology: What deficits reveal about the human mind’. Philadelphia: Psychology Press. | 2022-12-18T07:23:44.229Z |
163,584,258 | {
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"DOI": "10.2307/406988",
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} | Das erst seit kurzem zugingliche Friihwerk Alfred D6blins ist aufschluBreich nicht nur als Schliissel zum reifen Werk. An diesen fruihen Schriften la6t sich auch erkennen, wie der junge Autor auf zeitgeschichtliche Entwicklungen, seien sie nun sozio-politischer oder poetologischer Art, reagierte. D6blin, dessen autobiographische Zeugnisse spat einsetzten und spirlich blieben, zeigt sich hier noch direkter, unverschliisselter. Ideen und Meinungen sind noch nicht festgelegt; er nimmt Verschiedenes auf, la6t manches wieder fallen, wihrend gewisse Konstanten bleiben. So weist das friiheste erhaltene Manuskript, die Prosaskizze "Modern. Ein Bild aus der Gegenwart" schon wichtige Ansitze des Spitwerks auf: das Thema der Grolstadt, die Identifizierung mit den Nichtprivilegierten, die sexuelle Problematik und die Suche nach religioser Erl6sung. Auch in formaler Hinsicht deutet sich schon das Experimentelle in der Vielschichtigkeit der Erzihlweise, dem Nebeneinander von Tatsachenmaterial und fiktiver Darstellung und der Verwendung verschiedener Sprachebenen an. | 2022-01-27T10:55:25.928Z |
227,001,996 | {
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"DOI": "10.3760/CMA.J.ISSN.0254-1785.2015.06.001",
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} | Objective
To analyze the outcomes of renal transplantation from donation after citizen death (DCD) in our single center.
Method
We retrospectively investigated the recipient outcomes of renal allografts from DCD. Between November 2010 and 31st December 2014, our institution performed 242 renal transplants from DCD. Outcome variables (survival of recipients/allografts and adverse events) and characteristics of marginal donor transplants were analyzed.
Result
There were 139 males and 44 females in the enrolled 183 donors, and the range of age was from 2 days to 68 years. 183 donors included 102 cases of donation after brain death (category Ⅰ), 22 cases of donation after circulatory death (category Ⅱ) and 59 cases of donation after brain death followed by circulatory death (category Ⅲ). Utilizing these renal allografts, we performed 242 kidney transplantations including 237 single kidney transplants and 5 pediatric en bloc kidney transplants. The age of recipients ranged from 12 to 64 years. The data indicated that the 1-year recipient/allograft survival rate was 93.8% and 90.5%, respectively. The rate of delayed graft function (DGF) was 33.1%, higher than that from executed prisoners allografts (23.6%, P<0.05). However, the rate of 1-year acute rejection, interstitial pneumonia and the other adverse events (urinary fistula, ureteral obstruction and cardiac and cerebral vascular accident, etc.) was similar to that from executed prisoners allografts. In addition, good results from pediatric and elder donor renal transplantation were shown in our data, even though the discard rate of elder donor kidney was high.
Conclusion
By comprehensive evaluation, strictly screening donors and enhancing the management of donors, the long-term survival of recipients may be prolonged and the incidence of DGF and primary graft non-function (PNF) may be decreased. The marginal donors from pediatric and elder DCD donors could be utilized in clinical transplantation safely and effectively as long as reasonable evaluation was carried out.
Key words:
Donors; Donor selection; Kidney transplantation; Graft survival; Organ harvesting | 2022-02-07T23:38:16.839Z |
25,807,803 | {
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"DOI": "10.2527/JAS1989.6771740X",
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} | This study was conducted to examine serum cortisol concentrations and adrenal cortisol output in pigs treated chronically with recombinant pGH (rpGH) at a maximally effective anabolic dose. Recombinant pGH (140 micrograms/kg body weight) was administered daily to eight barrows for 77 d. At slaughter, adrenal glands were removed, weighed and sliced; slices of fresh adrenal tissue were incubated for 1 h in the presence or absence of ACTH. Recombinant pGH increased adrenal weight by 39%. This change was accompanied by an inversely proportional reduction of in vitro cortisol output per gram of tissue, with the net result that total cortisol output per adrenal per kilogram of BW was unaltered, as was cortisol output in the presence of ACTH. Serum cortisol concentrations were measured in 10 barrows fitted with femoral artery catheters and treated daily with 0 or 140 micrograms rpGH/kg BW for 8 d. Basal and ACTH-stimulated cortisol concentrations were not altered by rpGH treatment. These results do not support our earlier speculation that a pGH-dependent increase in adrenal weight is associated with a chronic increase in adrenal activity, but rather demonstrate that corticosteroid output is tightly regulated and remains constant despite a marked increase in the size of the adrenal glands. | 2022-02-12T17:55:03.620Z |
147,698,439 | {
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"DOI": "10.1525/NCLR.2016.19.3.437",
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} | All of the current prevailing theories of criminal punishment ultimately depend on some sort of normative argument to justify why the state may penalize people found guilty of crimes. Yet each of these theories lacks a strong epistemological foundation to explain how we can know what form punishments should take. This article analyzes the epistemological gaps in the predominant theories of punishment and finds that the putative epistemological sources they do use fall short of actual knowledge. The lack of an epistemological underpinning for punishment puts the very validity of punishment in doubt. Systems for quantifying punishment, such as proportionality and sentencing guidelines, only lend an appearance of knowledge to penalization. They are not true epistemological arguments. Although social norms may at first seem to provide the bases of the requisite knowledge, norms are themselves epistemically difficult to identify, let alone prove. The article concludes that a sound epistemological basis is intrinsically unattainable in the practice of criminal punishment. The best that we can achieve as an epistemologically justifiable punishment is to follow the regulative principle of “suitability” by relying on a mixture of social norms and specific empirical observation. | 2022-08-01T17:35:56.016Z |
97,513,609 | {
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"DOI": "10.1021/ED033P322",
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} | The principal aim of this article is to show how distribution data can readily and satisfactorily be used to deduce molecular equilibria in appropriate cases, and to illustrate this with simple examples. | 2022-09-03T19:33:06.154Z |
96,206,407 | {
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"DOI": "10.1006/JSSC.1998.8077",
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} | Abstract The structure of La 0.8 Sr 0.2 Ga 0.85 Mg 0.15 O 2.825 was studied by powder neutron diffraction and transmission electron microscopy. Neutron powder diffraction revealed cubic symmetry but electron diffraction and imaging showed the presence of local superstructures with symmetry lower than the average cubic. The thermal stability of the superstructures was investigated using high-temperature electron diffraction. One of the superstructures was related to ordering of the oxygen vacancies into planes normal to 〈100〉 c . Increasing the temperature destroys this planar ordering and eliminates the associated streaking on the electron diffraction pattern. The temperature of the disappearance of the streaking correlates with the change in conduction activation energy above 500°C. After rapid cooling in the electron microscope, the ordering is fully restored to its original form, consistent with the hypothesis that the superstructure is formed by ordering of a very mobile ion, such as oxygen, in La 0.8 Sr 0.2 Ga 0.85 Mg 0.15 O 2.825 . | 2022-09-23T21:47:42.262Z |
135,903,461 | {
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"DOI": "10.1088/1742-6596/150/4/042198",
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"status": "GOLD",
"url": "https://doi.org/10.1088/1742-6596/150/4/042198"
} | Nanoparticles of multiferroic material BiMnO3 were synthesized in the pores of the mesoporous silica SBA-15 and their magnetic properties were investigated. The powder X-ray diffraction pattern for the nanoparticles at room temperature was similar to that for bulk crystals with monoclinic symmetry. The particle size of the nanocrystals was estimated to be about 14 nm using Scherrer's equation. The temperature dependence of the DC susceptibilities for the nanoparticles showed superparamagnetic behavior. The susceptibility and thermoremanent magnetization exhibited the ferromagnetic feature and the ferromagnetic transition temperature was almost same to that for bulk crystals, ≈ 100 K. However, the Weiss temperature Θ was evaluated as the negative value and the magnetization curve showed antiferromagnetic behavior. The results suggest the antiferromagnetic properties appeared prominently in the nanoparticles. | 2022-11-25T18:40:47.336Z |
92,982,434 | {
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"DOI": "10.1080/15248372.2018.1523172",
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"status": "GREEN",
"url": "https://europepmc.org/articles/pmc6594696?pdf=render"
} | ABSTRACT This research investigates the development of constraints in word learning. Previous experiments have shown that as infants gain more knowledge of native language structure, they become more selective about the forms that they accept as labels. However, the developmental pattern exhibited depends greatly on the way that infants are introduced to the labels and tested. In a series of experiments, we examined how providing referential context in the form of familiar objects and familiar object names affects how infants learn labels that they would otherwise reject, nonspeech sounds. We found evidence of the development of intersecting constraints: Younger infants (14-month-olds) were more open to learning nonspeech tone labels than older infants (19-month-olds), and younger infants were more open to the influence of referential context. These findings suggest that infants form expectations about labels and labeling contexts as they become more sophisticated learners. | 2022-12-03T21:44:39.759Z |
207,943,452 | {
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"DOI": "10.1093/geroni/igz038.1561",
"MAG": "2983713842",
"PubMedCentral": "6840033"
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"license": "CCBY",
"status": "GOLD",
"url": "https://academic.oup.com/innovateage/article-pdf/3/Supplement_1/S418/33006806/igz038.1561.pdf"
} | Abstract We examined age/cohort profiles of income inequality in the Survey of Consumer Finances for 2007, 2010, and 2016. Overall, the Gini coefficient decreased somewhat following the 2008 onset of the Recession, but rebounded by 2016 to a higher level than the 2007 baseline. Within-cohort inequality trends from 2007-2016 differed considerably across cohorts. For late baby boomers and millennials, inequality increased sharply – from .56 to .67 for the 1963-1972 birth cohort and from .49 to .60 for the 1973-1982 birth cohort. Inequality was higher at baseline for early baby boomers than later cohorts but did not increase as they moved into midlife and early late life. The Great Recession, with its large drops in asset values, initially led to slight reductions in inequality, but this effect was temporary. Late boomers and millennials experienced sharp increases in inequality following the Recession, presaging a very high-inequality late-life experience for these cohorts. | 2022-12-10T10:26:09.260Z |
73,473,062 | {
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"DOI": "10.14444/6002",
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},
"license": null,
"status": "GOLD",
"url": "http://www.ijssurgery.com/content/ijss/13/1/17.full.pdf"
} | ABSTRACT Background: Symptomatic or asymptomatic transitional anomalies at the lumbosacral junction are common occurrences in the population. Lumbosacral (L5-S1) accessory articulations are the most common presentations of transitional anomalies at this region. Such anatomical alterations are believed to be associated with biomechanical changes of load-bearing and movement restrictions leading to low back pain. This study attempts to use computational models of a normal and a lumbosacral transitional vertebrae (LSTV) accessory articulation to analyze and compare the range of motion and loading patterns at the lumbosacral articulations. Methods: Three-dimensional Finite Element computational models of normal and accessory L5-S1 articulated sacrum were created. These models were tested for range of motion and stress patterns generated at the lumbosacral articulations using similar loading and motion simulation to elicit different moments/excursions at the lumbosacral junctions. Results: Compared to the normal variant, the transitional model exhibited different range of motion and divergent patterns of stress generation at the lumbosacral and accessory articulations with equal and physiological magnitudes of loading applied to both the models. Conclusions: The finite element modeling approach can be used for biomechanical investigations in LSTV variants. However, larger sample studies with different LSTV models may be required to statistically compare movement and loading patterns at LSTV-affected lumbosacral and sacroiliac junctions, and to recommend definitive treatment strategies in these situations. | 2022-12-10T23:30:41.441Z |
18,255,566 | {
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"DOI": "10.1109/ICMA.2010.5588318",
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} | A novel infrared (IR) and visible image fusion method based on nonsubsampled contourlet transform (NSCT) and fuzzy logic is proposed. Input IR and visible images are decomposed into a series of low frequency and high frequency subbands by using NSCT. The degree of membership to the background and the target for each pixel in the low frequency subband of the IR image is determined by using fuzzy logic. An adaptive weighted average is then taken as the fusion of low frequency subband coefficients while maximum absolution selection is performed for the fusion of high frequency subband coefficients. The fused image is obtained by taking inverse NSCT of the fused coefficients. Experimental results with real IR and visible images show that the proposed method effectively enhances infrared targets and preserves details of the visible image. | 2022-10-01T15:45:11.929Z |
3,241,907 | {
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"DOI": "10.1109/ICMTMA.2017.0029",
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} | Current transformer (CT) saturation may result in the distortion of CT secondary current, which will give rise to improper operation of relay protection devices in power system. In this paper, a novel scheme is proposed to detect CT saturation and assess the level of saturation. After analyzing the probability distribution of current sampling data, it is found that the calculated skewness using data within given data window is positive when saturation occurs. However, under unsaturation condition, the calculated skewness using relevant data is negative. Utilizing this difference, a criterion function is defined to detect CT saturation, and a coefficient is determined to assess the level of saturation. Simulation results show the effectiveness of the proposed scheme, and tests using the on-site recorded current signal revel that there is an obvious advantage to implement the proposed scheme in a real system. | 2022-09-12T03:08:39.685Z |
166,242 | {
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"DOI": "10.3109/00016488809125106",
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} | For this study, 100 human temporal bones from 73 individuals, aged 31 gestational weeks to 39 years, each with anomalies of the middle and/or inner ear, were studied to identify the features, locations, and frequencies with which congenital anomalies occurred in these structures. The temporal bones had been removed at autopsy, fixed, dehydrated, embedded in celloidin, sectioned horizontally or vertically at 20 microns, stained with hematoxylin and eosin, and studied under a light microscope. The anomaly in the middle ear most often found was wide dehiscence of the facial canal; hypoplastic cochlea was most frequently observed anomaly in the inner ear. The implications of these findings for development of the ear during fetal life are discussed. | 2022-09-30T16:41:27.744Z |
235,454,518 | {
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"DOI": "10.1109/CIYCEE49808.2020.9453102",
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} | The reliability of circuit breaker state identification greatly affects the application range of sequence control and remote control. And safety regulations require at least two criteria based on different identical principles and signals to determine the state of the equipment after operation. In this paper, based on the intelligent comparison of current and impedance, comprehensive criterion and warning technology of circuit breaker state is proposed. Based on the injection circuit, the current and voltage of the injected signal are detected and the characteristic change of zero sequence resistance is calculated to realize the on-Line loop impedance monitoring. And the loosing or aging problem of circuit breaker can be found out. While the state monitoring criterion of circuit breaker is proposed, which uses the existing measurement data to constitute the state confirmation criterion. | 2022-01-27T01:28:53.406Z |
20,295,681 | {
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"DOI": "10.11604/pamj.2016.25.252.11345",
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"url": "https://doi.org/10.11604/pamj.2016.25.252.11345"
} | Basosquamous carcinoma (BSC) is a rare skin cancer which has areas of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) and a transition zone between them. However, dermoscopic features of BSC are not well described in the literature, except for two studies. The aim of this case study was to better identify and clarify the role of dermoscopy in the diagnosis of BSC, although histological confirmation is necessary. | 2022-04-08T00:23:54.116Z |
84,319,114 | {
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} | In this study, we investigated effects of 24 weeks of food deprivation on covering behavior of Glyptocidaris crenularis and Strongylocentrotus intermedius. Neither G. crenularis nor S. intermedius significantly reduced covering behavior during both short- and long-term food deprivation. However, G. crenularis and S. intermedius had significantly different behavioral patterns over the 24 weeks. Covering behavior of G. crenularis greatly increased from the first to the second week, with decreasing reaction time and increasing covering ability, while the covering behavior of S. intermedius generally remained unchanged during the experiment of 24 weeks. As prolonged food deprivation does not significantly affect covering behavior of G. crenularis and S. intermedius, the present study highlights the innate nature and biological significance of covering behavior in sea urchins, providing new insights into its behavioral mechanism. | 2022-07-30T21:34:06.856Z |
92,631,892 | {
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"DOI": "10.1101/557058",
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"url": "https://www.biorxiv.org/content/biorxiv/early/2019/02/21/557058.full.pdf"
} | During mitosis centrosomes can affect the length of kinetochore-fibers (k-fibers) and the stability of kinetochore-microtubule attachments, implying that they regulate k-fiber dynamics. The exact cellular and molecular mechanisms by which centrosomes regulate k-fibers remain, however, unknown. Here, we created human non-cancerous cells with only one centrosome to investigate these mechanisms. Such cells formed highly asymmetric bipolar spindles that resulted in asymmetric cell divisions. K-fibers in acentrosomal spindles were shorter, more stable, had a reduced poleward microtubule flux at minus-ends, and more frequent pausing events at their plus-ends. This indicates that centrosomes regulate k-fiber dynamics both locally at minus-ends and far away at plus-ends. At the molecular level we find that the microtubule-stabilizing protein HURP is enriched on the k-fiber plus-ends in the acentrosomal spindles of cells with only one centrosome. HURP depletion rebalance k-fiber stability and dynamics in such cells, and improved spindle and cell division symmetry. Our data further indicate that HURP accumulates on k-fibers inversely proportionally to half-spindle length. We propose that centrosomes regulate k-fiber plus-ends indirectly via length-dependent accumulation of HURP. Thus by ensuring equal k-fiber length, centrosomes promote HURP symmetry, reinforcing the symmetry of the mitotic spindle and of cell division. | 2022-08-24T22:21:51.849Z |
21,773,732 | {
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} | New development in material and production technology influences the design of electrical machines. This paper presents a theoretical calculation and experimental verification of a single-phase semi claw-pole machine, which core is made of Soft Magnetic Mouldable Composite - SM2C. In comparison with a conventional claw-pole configuration the semi-claw pole machine has a higher torque capability. This is due to a slightly increased winding arrangement. | 2022-08-25T00:02:34.045Z |
114,122,681 | {
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"DOI": "10.2172/1244615",
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"url": "https://inldigitallibrary.inl.gov/sites/sti/sti/6799570.pdf"
} | Battelle Energy Alliance, LLC, managing and operating contractor for the U.S. Department of Energy’s (DOE) Idaho National Laboratory (INL), is the lead laboratory for U.S. Department of Energy’s Advanced Vehicle Testing Activity (AVTA). INL’s conduct of the AVTA resulted in a significant base of knowledge and experience in the area of testing light-duty vehicles that reduced transportation-related petroleum consumption. Due to this experience, INL was tasked by DOE to develop agreements with companies that were the recipients of The American Recovery and Reinvestment Act of 2009 (ARRA) grants, that would allow INL to collect raw data from light-duty vehicles and charging infrastructure. INL developed non-disclosure agreements (NDAs) with several companies and their partners that resulted in INL being able to receive raw data via server-to-server connections from the partner companies. This raw data allowed INL to independently conduct data quality checks, perform analysis, and report publicly to DOE, partners, and stakeholders, how drivers used both new vehicle technologies and the deployed charging infrastructure. The ultimate goal was not the deployment of vehicles and charging infrastructure, cut rather to create real-world laboratories of vehicles, charging infrastructure and drivers that would aid in the design of future electric drive transportation systems. Themore » five projects that INL collected data from and their partners are: • ChargePoint America - Plug-in Electric Vehicle Charging Infrastructure Demonstration • Chrysler Ram PHEV Pickup - Vehicle Demonstration • General Motors Chevrolet Volt - Vehicle Demonstration • The EV Project - Plug-in Electric Vehicle Charging Infrastructure Demonstration • EPRI / Via Motors PHEVs – Vehicle Demonstration The document serves to benchmark the performance science involved the execution, analysis and reporting for the five above projects that provided lessons learned based on driver’s use of the vehicles and recharging decisions made. Data is reported for the use of more than 25,000 vehicles and charging units.« less | 2022-09-07T06:56:45.960Z |
219,383,887 | {
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"DOI": "10.2139/ssrn.3162941",
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} | Hicks was quite clear in his 1937 Econometrica paper that his model of IS-LM was based directly on Keynes’s IS-LM model of the General Theory with minor embellishments. In his closing paragraph, Hicks is very clear that it is Keynes, not Hicks, who proposed the first IS-LM model: “These, then, are a few of the things we can get out of our skeleton apparatus. But even if it may claim to be a slight extension of Mr. Keynes’ similar skeleton...” (Hicks, 1937, p. 158). Hicks had, of course, realized that Keynes had already considered, and rejected, his “really General” Theory because it removed both expectations and uncertainty from the original model. Keynes was quite explicit in his reply to Hicks: “At One Time I Tried the Equations, as You Have Done, with I in All of Them”. In fact, Hicks’s “equations”, which are actually not equations at all ,but mere functional relationships expressed between dependent and independent variables of the form y=f(x) and z=h(q), are identical to those presented by Keynes in chapter 21 of the General Theory on pages 298-299.The only actual equations appear in the General Theory on pages 115, 199, and 208-209. It is shown that Hicks’s figures one and two on page 153 are simply graphical translations of Keynes’s specific descriptions contained on pages 200-202, 207 of the General Theory and Keynes’s analysis of the missing LM equation from the neoclassical theory contained on pages 179-182 of the General Theory. Hicks’s discussion of an horizontal IS curve, in relation to Keynes’s discussion of Wicksell on page 242 of the General Theory, is the only “slight extension” offered by Hicks. It is demonstrated that the economics profession has been completely bamboozled for 82 years by the canards, fictions, fables, myths, tall tales, and stories told about Keynes by a mathematically innumerate, illiterate, inept, and confused economist, named Joan Robinson, based on her claims that in the General Theory, Keynes only used the Marshallian, partial equilibrium modeling approach. Keynes supposedly refused to use a system of mathematical, simultaneous equations because, as a fanatic disciple of Marshall, he would always burn his mathematical analysis and replace it with a strictly literary summary after checking to make sure that the mathematical analysis supported the literary analysis. Robinson had no idea about how to specify or analyze a system of simultaneous, mathematical equations because she had never taken an introduction to pre-algebra course. The entire history of macroeconomics needs to be completely rewritten by economists. They have integrated the faulty claims introduced by Joan Robinson, a self admitted mathematical illiterate, into their histories. In retrospect, one can ask the following question: How could a mathematical illiterate, like Joan Robinson, have been taken seriously as the major source upon which to base the foundation for an assessment of Keynes’s GT? It is simply a catastrophic, egregious error that has ramifications for questions about the scientific respectability of the economics profession. Hicks admitted in 1937 that he had made only a slight improvement over Keynes ‘s model. Keynes established that absolute liquidity preference, which was represented by the “flattened” horizontal portion of his LP equation in (r,Y) space on page 207 of the GT, which was called a Liquidity “Trap” by others, would occur once the long run rate of interest fell below a rate of 2% or 2.5%. This is identical to a short run rate approaching or equaling 0%, once the various premiums are subtracted from the long run rate or added to the short run rate. Krugman has constantly maintained this position since the early 1990’s in the face of spurious attacks based on the baseless assertion that there was no IS-LM model in the GT. Hicks’s own admission in 1937, never repeated or clarified afterwards by Hicks, that his model represented only a slight improvement over Keynes’s, should end any support for the baseless claims of Joan Robinson. The most severe errors currently embedded in histories of macro economics concerning the impact of the GT can all be traced directly to Joan Robinson. The reader is asked to consult the many papers I have available on SSRN chronicling her many, myriad errors, errors which are embedded in heterodox and orthodox assessments of Keynes’s GT. | 2022-09-07T07:39:56.514Z |
25,962,595 | {
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} | Ab to the acetylcholine receptor (AChR) cause experimental myasthenia gravis (EMG). Th1 cytokines facilitate EMG, whereas Th2 cytokines might be protective. IL-10 inhibits Th1 responses but facilitates B cell proliferation and Ig production. We examined the role of IL-10 in EMG by using wild-type (WT) C57BL/6 mice and transgenic (TG) C57BL/6 mice that express IL-10 under control of the IL-2 promoter. We immunized the mice with doses of AChR that cause EMG in WT mice or with low doses ineffective at causing EMG in WT mice. After low-dose AChR immunization, WT mice did not develop EMG and had very little anti-AChR serum Ab, which were mainly IgG1, whereas TG mice developed EMG and had higher levels of anti-AChR serum Ab, which were mainly IgG2, in addition to IgG1. At the higher doses, TG mice developed EMG earlier and more frequently than WT mice and had more serum anti-AChR Ab. Both strains had similar relative serum concentrations of anti-AChR IgG subclasses and IgG and complement at the muscle synapses. CD8+-depleted splenocytes from all AChR-immunized mice proliferated in the presence of AChR and recognized a similar epitope repertoire. CD8+-depleted splenocytes from AChR-immunized TG mice stimulated in vitro with AChR secreted significantly more IL-10, but less of the prototypic Th1 cytokine IFN-γ, than those from WT mice. They secreted comparable amounts of IL-4 and slightly but not significantly reduced amounts of IL-2. This suggests that TG mice had reduced activation of anti-Torpedo AChR Th1 cells, but increased anti-AChR Ab synthesis, that likely resulted from IL-10-mediated stimulation of anti-AChR B cells. Thus, EMG development is not strictly dependent on Th1 cell activity. | 2022-09-14T00:59:46.023Z |
8,216,690 | {
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} | In this note, we show how to determine the set of stabilizing parameters of a proportional-integral-derivative controller for an integrator plus dead time process. In particular, by exploiting a version of the Hermite-Biehler theorem applicable to quasipolynomals, the admissible range of the proportional gain is computed first. Then, for each value of the proportional gain in that range, the set of stabilizing values of the integral and derivative gain are found. It is shown that the procedure is greatly simplified with respect to the case of a second-order integral process with dead time. | 2022-10-03T14:06:38.467Z |
115,013,913 | {
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} | This paper deals with the stability of an offshore barge when subjected to parametric rolling in longitudinal waves. The main aim of this paper is to understand the roll behaviour of an offshore barge under longitudinal waves, to predict the susceptibility of parametric rolling in longitudinal waves and to identify the region of instability when subjected to parametric rolling. The primary objective is to find the roll response of a geometrically modeled offshore barge in ANSYS AQWA for regular sea conditions followed by the calculation of roll response in a conservative way by the Linear Strip theory to validate with the results obtained from ANSYS AQWA. Two major cases were studied; once when the length of the waves is equal to the length of the barge and the other when the length of the encountering waves is four times the length of the barge The severity of the parametric rolling for the offshore barge is calculated by the mathematical modeling for solution of Mathieu’s Differential equation using Matlab programming, taking in account the stability parameters for the offshore barge for which stability curves are plotted. This Graphical InceStrutt diagram was then verified by numerical modeling to illustrate the instability of barge. The boundary approximations for the instability zone for which frequencies prone to parametric roll resonance were identified and their threshold damping coefficient was then calculated. Keywords— Parametric rolling, rolling, hydrodynamic, roll resonance, barge, longitudinal waves, strip theory. | 2022-09-16T02:40:26.911Z |
205,545,018 | {
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"DOI": "10.1111/j.1464-410X.2011.10333.x",
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} | What’s known on the subject? and What does the study add? | 2022-12-17T10:14:44.157Z |
145,004,161 | {
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} | Where do we draw the line on the adage that "good fences make good neighbours?" The iconic Robert Frost verse is much quoted, but do longer, higher, barbed-wire, electrified, security-patrolled, and access-controlled fences make for still better neighbours? This question embodies the essence of current continuing tensions along the Canadian-US borders. The traditional "longest undefended cliche" is quickly becoming a 20thcentury artefact with levels of security and proposals for much, much more than would have been conceivable a decade ago, before 11 September 2001. Admittedly, this circumstance would barely be recognized as a constraint, let alone a problem, throughout much of the world in historical or even current terms, where crossing a national border is a serious personalpolitical decision. (Try getting a visa to Russia or China if you want a lesson in bureaucratic frustration.) Nevertheless, due to the unique US-Canadian relationship, its recent evolution needs examination.Certainly, from time immemorial until n September 2001, the reality of the North American continent was the virtually free movement of populations - animal and human. Well before there was significant human presence, the "fauna" drifted (and for that matter the "flora" as well, albeit more slowly) with no special regard for anything beyond the availability of grass and water, favourable climate, and fewer predators. Much of North America was a sea of grass "where the deer and the antelope play" and a roaming herd of buffalo could take much of a day to pass a given landmark.Nor did anything beyond the nomadic pursuit of wildlife impinge on the travels of most native Americans: they came; they camped, gathered, hunted, and feasted; and they moved again for the next season or hunting opportunity. The Head- Smashed-in-Buffalo- Jump site in Alberta epitomizes such a style of life. While specific tribes were more or less found in general locations, geographic constraints were minimal. And, so far as European arrival on the continent was concerned, the specific location of boundaries was a technical-political concern rather than one of serious socioeconomic significance to individuals. Both Canada and the United States sought people to fill the empty space in the centre of the continent and thereby generate prosperity from farming, ranching, and mining. In that regard, the primary difference in the 19th and early 20th century between a Canadian and a US citizen was between an immigrant who turned right rather than left while traveling west across North America. And that is not to count the present-day Canadians and Americans whose ancestors originated in the other country, moving north or south at will and whim. Primarily, these were people seeking precious metals, better land, more reliable water, closer trailheads, and generally enhanced economic opportunity, rather than viewing where they lived as an immutable national label for citizenship.To be sure, there were specific territorial conflicts and persisting unresolved boundary differences; however, for generations the Canadian-US border has been socially and economically fluid, despite clearly surveyed and carefully marked boundary lines. There are endless anecdotes demonstrating a genuine neighbourly spirit more akin to the relations of congenial residents on a city block than those between two nations. Witness, for example: the children of Point Roberts in Washington state, who are bussed to school through British Columbia and get most of their services from Canada; the library and opera house in Derby Line, Vermont, that sit in both the United States and Stanstead, Quebec; the women of Stanstead, Quebec, who had their babies in Vermont when labour came on more quickly than expected, because that's where the closest clinic was, and whose children were then dual nationals, having been born in the US; Canusa Avenue, in Beebe Plain, Vermont, which runs east-west and whose northside residents are Canadians while its southside residents are Americans; the children's sports teams across the continent that regularly play opponents from schools in the other country; the thousands of daily workers and shoppers who live in one country and work in the other - and pick up "specials" on the way home; and the many instances where emergency vehicles and volunteer fire departments in one country respond to accidents and fires in the other. … | 2022-02-09T06:40:29.458Z |
109,211,920 | {
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"DOI": "10.2495/SDP130201",
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} | The change of the Arabian Gulf cities due to the sudden development in wealth after the unearthing of oil has been a subject of curiosity and concern for many years. This paper is based on a completed master's study which investigated the effects of the discovery of oil on the urban identity of Bahrain, by examining the relationship between the old and the new in the urban fabric. The thrust of the study further focused on exploring the role of two governmental institutions, the Ministry of Culture and the University of Bahrain, in stimulating this change. Using a qualitative research approach, the study employed a number of different sources of data. The first group, including archival resources, journal and newspaper articles, in addition to the diaries and writings of Englishmen, especially those of the British advisor Sir Charles Belgrave, aimed at investigating the change in the urban fabric of Bahrain since the discovery of oil. The second group, including questionnaires and interviews, aimed at examining the consequences of this change in the work of the two governmental institutions today. The study provides a description of the change in the urban identity of Bahrain, and an understanding of how the effects of this change in shaping the lifestyle and ideologies of people living on the islands today. Some limitations in the practices of the two institutions are highlighted, and recommendations for both the Ministry of Culture and the University of Bahrain are proposed. | 2022-03-08T08:36:15.184Z |
143,357,636 | {
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"DOI": "10.3917/AGORA.062.0033",
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} | En evaluant les resultats et les effets du programme Diapason sur l’integration scolaire, culturelle et sociale des eleves primo-arrivants non francophones d’une classe d’accueil, on a constate que le contexte didactique cree par le programme avait une influence sur le rapport au savoir des acteurs impliques dans l’experimentation. Les ateliers de pratique artistique conditionnent les situations non formelles d’apprentissage qui agissent sur la scolarite des eleves, mais aussi sur les pratiques professionnelles des enseignants et la creativite des artistes-intervenants. | 2022-03-30T15:13:51.132Z |
242,632,442 | {
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"DOI": "10.21203/rs.3.rs-20254/v1",
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"license": "CCBY",
"status": "GREEN",
"url": "https://www.researchsquare.com/article/rs-20254/latest.pdf"
} |
Background Although hip arthroplasty has become increasingly common, its radiological and clinical outcomes in chronic renal failure patients remain unclear. This study analyzed the outcomes of hip arthroplasty in patients with chronic renal failure undergoing dialysis. Methods Of 2,364 hips undergoing total hip arthroplasty or bipolar hemiarthroplasty between January 2003 and December 2017, data pertaining of 37 hips of patients with chronic renal failure undergoing dialysis (16 men, 21 women) were retrospectively examined. We analyzed the radiological and clinical outcomes of hip arthroplasty, as well as the occurrence of local and general complications (particularly the time of their occurrence) during follow-up and their association with dialysis duration. Results The mean patient age was 60.6 ± 13.5 years, and the mean follow-up duration was 36.6 ± 27.2 months. The mean T-value indicating bone mineral density was -2.62 ± 1.15, with osteoporosis noted in 20 cases. Except for 1 case with infection-induced change in acetabular cup tilt, all cases of total hip arthroplasty with cementless acetabular cup implant exhibited excellent radiographic outcomes. The cementless proximally coated femoral stem was used in all 25 cases of total hip arthroplasty and 7 out of 12 cases of bipolar hemiarthroplasty. Changes in the alignment of femoral stems, subsidence, osteolysis, and loosening were not observed. On clinical assessment, 33 patients received an “excellent” or “good” Harris hip score. Within 1 year postoperatively, complications developed in 18 patients, and some patients exhibited more than 1 complication. More than 1 year after surgery, general complications developed in 12 patients; however, no patient experienced local complications.Conclusions Hip arthroplasty in chronic renal failure patients on dialysis showed excellent radiological and satisfactory clinical outcomes; however, it may be associated with various postoperative complications. Therefore, meticulous preoperative treatment planning and overall postoperative management are required to reduce the risk of complications. | 2022-07-31T05:23:23.719Z |
251,238,108 | {
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"url": "https://studiahumanitatisjournal.com/revista/index.php/shj/article/download/66/73"
} | En el momento de escribir este trabajo, estamos viendo y sufriendo las consecuencias de más de tres meses de guerra en Ucrania, iniciada el 24 de febrero de 2022. Como europeo y español no podía concebir que, tras la Guerra Fría, la postguerra fría y el llamado Nuevo Orden Mundial, de carácter multipolar, con una tendencia creciente a la democratización de los estados, con una nueva agenda internacional con nuevos retos como el cambio climático, la reducción de los armamentos, los problemas demográficos, etc., pudiera estallar una guerra convencional en el Este de Europa. Protagonizada por una de las antiguas superpotencias, Rusia, hoy convertida en una estado autoritario, represor y antioccidental, que ha invadido el territorio de una de sus antigua repúblicas federadas, Ucrania, transformada en una democracia consolidada, abierta a Occidente, europeísta y con un gran progreso económico y social. | 2022-08-03T22:12:21.416Z |
11,054,527 | {
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"DOI": "10.1109/IISA.2013.6623678",
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} | A data mining of Time Series using Autocorrelation Coefficients (ACC) and LVQ -Neural Network is addressed in this work-a problem that has not yet been seen in a signal processing framework, to the best of our knowledge. Neural network classification was performed on real Time series Data of real data, in an attempt to experimentally investigate the connection between Time Series data and hidden information about the properties of stationary Time Series. Finally, the ability of the ACC will be tested via a well fitted LVQ neural network which gives satisfactory results in predicting Time Series. | 2022-09-12T23:17:38.722Z |
252,954,528 | {
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"DOI": "10.2298/theo2203005p",
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"url": "http://www.doiserbia.nb.rs/ft.aspx?id=0351-22742203005P"
} | Epicureans and Roman Stoics interpreted pleasure (?????) differently from
each other: for the Epicureans, pleasure was the ultimate good, while most
Stoics perceived pleasure as something indifferent. This difference in
understanding of pleasure is the crucial point of a disagreement between
these two Hellenistic schools of philosophy, in particular if we consider
their ethics. This paper examines this difference and highlights the
significant similarities between the Roman Stoic and the Epicurean
positions. Further, it briefly explores the Epicurean and the Roman Stoic
understanding of social relations and philosophers? role in politics and
society. | 2022-10-21T00:50:52.585Z |
12,003,243 | {
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"DOI": "10.12968/BJON.1993.2.7.358",
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} | This article describes the actions of hydrocolloid dressings and the type of wounds for which they are most suitable. The range of hydrocolloid products is reviewed along with their individual advantages and disadvantages. | 2022-12-04T20:29:07.563Z |
18,647,458 | {
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"DOI": "10.1111/J.1475-682X.2011.00378.X",
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} | We adapt a metaphor from life course studies to designate the whole of one's possessions, across time, as a convoy of material support. This dynamic collection of things supports daily life and the self, but it can also present difficulty in later life. To alleviate the purported burdens of the material convoy, a discourse has arisen that urges elders and their family members to reduce the volume of possessions. An analysis of 11 such possession management texts shows authors addressing two distinct audiences about elders' need to downsize: family members and elders themselves. Authors who speak to family members do so with an urgent, unsentimental tone that echoes mainstream clutter-control advice about disorderly, overfull households. In texts for elders, the standard critique about consumption and unruly lives is gentler, more sensitive to the meaning of things, and underplays the emotions of divestment. There is stress on the responsibility to spare the next generation and control one's legacy. These latter texts seem to respect that downsizing in later life symbolizes a narrowing of the life world. | 2022-12-05T07:11:10.069Z |
896,156 | {
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"DOI": "10.1080/00140130500070871",
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} | This study was aimed to investigate complete recovery time (CRT) after exhaustion in high-intensity work. Twenty-four subjects were divided into two groups based on the cardiorespiratory capability index, which was measured in a maximum capacity test. Each subject then performed two cycling tests (at 60% and 70% maximum working capacity). The subject continued cycling until exhaustion in each test and then sat recovering until he/she no longer felt fatigue or until the oxygen uptake (VO2) and heart rate (HR) returned to their baselines, whichever was longer. The results indicated that HR required the longest time to recover and, consequently, HR data were adopted to set the CRT. The CRT was significantly correlated with the cardiorespiratory capability index and the relative workload indices: RVO2 and RHR. The RVO2 was the average elevation in VO2 during work from the resting level as a percentage of maximum VO2 reserve. The RHR's definition was similar to that of RVO2. Based on the obtained CRT-prediction model, the CRT for a high-cardiorespiratory-capability person was 20.8, 22.1, 23.4, and 24.7 min at 50%, 60%, 70%, and 80% RHR levels, respectively. These suggested CRT values should be increased by 10 min for a low-cardiorespiratory-capability person. | 2022-12-10T12:48:11.977Z |
28,890,979 | {
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} | AIM
This paper reports a study examining the relationships between demographic characteristics, social support, anxiety, coping and defence among women with possible breast cancer.
BACKGROUND
Awaiting a possible breast cancer diagnosis is an anxiety-provoking situation that demands coping. Social support and demographic characteristics have been reported to influence coping and well-being, but the interconnection is insufficiently understood.
DESIGN
A survey design was used, and self-administrated questionnaires were returned by a convenience sample of 117 women in Norway who had undergone breast biopsy. The data were collected from September 1998 to February 2000.
INSTRUMENTS
The instruments consisted of: the Social Provisions Scale, State-Trait Anxiety Scale, Utrecht Coping List and Defence Mechanisms Inventory. In addition, data on age, level of education, employment, marital status, and household status were collected.
RESULTS
Social support was positively related to instrumental-oriented coping and emotion-focused coping, unrelated to cognitive defence and defensive hostility. Educational level was positively related to instrumental-oriented coping. Educational level, employment and marital status were negatively related to cognitive defence. Educational level was the most important contributor to social support. Attachment and education were the most important contributors to instrumental-oriented coping, with education as the strongest predictor.
CONCLUSION
Better coping was linked primarily to education, and secondly to attachment. Unemployment, low level of education and single/divorced/widowed status were related to greater use of cognitive defence. Women who used a defensive hostile style tended to receive poor social support. Nurses need to be aware of the influence of demographic characteristics on social support, coping and defence and to identify poor copers, as these patients are most in need of professional support. | 2022-12-14T03:59:21.119Z |
218,859,329 | {
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"DOI": "10.1093/gbe/evaa105",
"MAG": "3026121043",
"PubMedCentral": "7486956"
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"license": "CCBY",
"status": "GOLD",
"url": "https://academic.oup.com/gbe/article-pdf/12/7/1087/33740953/evaa105.pdf"
} | Abstract Relaxed molecular clock methods allow the use of genomic data to estimate divergence times across the tree of life. This is most commonly achieved in Bayesian analyses where the molecular clock is calibrated a priori through the integration of fossil information. Alternatively, fossil calibrations can be used a posteriori, to transform previously estimated relative divergence times that were inferred without considering fossil information, into absolute divergence times. However, as branch length is the product of the rate of evolution and the duration in time of the considered branch, the extent to which a posteriori calibrated, relative divergence time methods can disambiguate time and rate, is unclear. Here, we use forward evolutionary simulations and compare a priori and a posteriori calibration strategies using different molecular clock methods and models. Specifically, we compare three Bayesian methods, the strict clock, uncorrelated clock and autocorrelated clock, and the non-Bayesian algorithm implemented in RelTime. We simulate phylogenies with multiple, independent substitution rate changes and show that correct timescales cannot be inferred without the use of calibrations. Under our simulation conditions, a posteriori calibration strategies almost invariably inferred incorrect rate changes and divergence times. The a priori integration of fossil calibrations is fundamental in these cases to improve the accuracy of the estimated divergence times. Relative divergence times and absolute timescales derived by calibrating relative timescales to geological time a posteriori appear to be less reliable than a priori calibrated, timescales. | 2022-12-16T02:48:54.290Z |
13,060,365 | {
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"ArXiv": null,
"DOI": "10.1093/bioinformatics/btw026",
"MAG": "2305364952",
"PubMedCentral": null
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"license": null,
"status": "BRONZE",
"url": "https://academic.oup.com/bioinformatics/article-pdf/32/10/1446/16920397/btw026.pdf"
} | MOTIVATION
DNA methylation is an epigenetic modification with important roles in many biological processes and diseases. Bisulfite sequencing (BS-seq) has emerged recently as the technology of choice to profile DNA methylation because of its accuracy, genome coverage and higher resolution. Current statistical methods to identify differential methylation mainly focus on comparing two treatment groups. With an increasing number of experiments performed under a general and multiple-factor design, particularly in reduced representation bisulfite sequencing, there is a need to develop more flexible, powerful and computationally efficient methods.
RESULTS
We present a novel statistical model to detect differentially methylated loci from BS-seq data under general experimental design, based on a beta-binomial regression model with 'arcsine' link function. Parameter estimation is based on transformed data with generalized least square approach without relying on iterative algorithm. Simulation and real data analyses demonstrate that our method is accurate, powerful, robust and computationally efficient.
AVAILABILITY AND IMPLEMENTATION
It is available as Bioconductor package DSS.
CONTACT
[email protected] or [email protected]
SUPPLEMENTARY INFORMATION
Supplementary data are available at Bioinformatics online. | 2023-01-01T17:11:11.983Z |
87,962,067 | {
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"DOI": "10.22377/IJGP.V7I1.298",
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} | Context: The persistent increase in the number of antibiotic resistant strains of microorganisms has led to the development of more potent but more expensive antibiotics. Synthetic drugs are mostly associated with side effects and are generally costly, hence are not affordable to economically poor class of the society when long term treatment is required, thus interest has been developed in the use of herbal medicines which have been reported to have either very little or no side effects. Aims: Present work was carried out to assess the antimicrobial activity of A. paniculata against some multidrug resistant pathogenic bacteria. Materials and Methods: Different parts (leaf, stem, root) of A. paniculata were collected and air dried and soxhlet extracted by using standard methods for flavonoid and alkaloid extraction. These extracts were then tested for antimicrobial activity using disc diffusion method. Minimum inhibitory concentration, Minimum bactericidal concentration and Total activity were also calculated. Statistical Analysis: Mean value and Standard Deviation were calculated for the test bacteria and fungi. Data were analysed by one‑way analysis of variance and P values were considered significant at P < 0.05. Results: C. albicans was found to be the most susceptible organism followed by P. mirabilis, S. aureus, E. coli, P. aeruginosa and A. flavus. A. niger and T. mentegrophyte were observed to be resistant as none of the tested extracts showed activity against them. Free flavonoid extract of root showed best activity against C. albicans (IZ 14 mm, MIC 0.156), whereas leaf free flavonoid extract showed maximum 21 mm inhibition zone against P. mirabilis.The range of MIC and MBC was found to be 1.25‑0.039 and 2.5‑0.078 respectively. Conclusion: Results of the present study reveal that extracts of A. paniculata are showing great antimicrobial potential against tested microorganisms, and may be exploited for future antimicrobial drugs Key words: Flavonoids, minimum inhibitory concentration, minimum bactericidal concentration and total activity | 2022-06-13T15:49:42.901Z |
191,974,468 | {
"externalids": {
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"DOI": "10.3138/CTR.144.5",
"MAG": "2021299023",
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},
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"url": null
} | Theresa J. May, director of a University of Oregon production and a prominent eco-theatre scholar, breaks bread and meditates on Marie Clements' groundbreaking play. | 2022-09-13T16:36:59.387Z |
1,552,689 | {
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"ArXiv": null,
"DOI": "10.1145/359488.359491",
"MAG": "2072215619",
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} | An algorithm is presented for copying an arbitrarily linked list structure into a block of contiguous storage locations without destroying the original list. Apart from a fixed number of program variables, no auxillary storage, such as a stack, is used. The algorithm needs no mark bits and operates in linear time. It is shown to be significantly faster than Fisher's algorithm, the fastest previous linear-time algorithm for the same problem. Its speed comes mainly from its efficient list-traversal technique, which folds the processing stack into the structure being built, and from its classification of list cells into nine types, which enables processing operations to be optimized for each type. | 2022-10-05T16:13:20.967Z |
125,613,344 | {
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"DOI": "10.1088/1674-1137/42/11/114102",
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} | The two-parameter formulae, i.e. the nuclear softness formula and the power index formula, have been used to obtain the band head spin (I0) of the triaxial superdeformed (SD) bands in 163Lu(1, 2, 3, 4), 164Lu(1, 2, 3) and 165Lu(1, 2, 3), in the A ∼ 160 mass region. The least squares fitting approach is used. The values of the root mean square (RMS) deviation among the computed and the measured experimental transition energies are obtained by calculating the model parameters. Whenever accurate spins are available, superb agreement is shown between the determined and the measured experimental transition energies. In comparison to the power index formula, the values of band head spin (I0) of the triaxial SD bands in 163Lu(1, 2, 3, 4), 164Lu(1, 2, 3) and 165Lu(1, 2, 3) obtained by the nuclear softness formula are closer to the experimental data. The lowest RMS deviation is also achieved by the nuclear softness formula. Hence, the nuclear softness formula works well for obtaining the band head spin (I0) for the triaxial SD bands in 163Lu(1, 2, 3, 4), 164Lu(1, 2, 3) and 165Lu(1, 2, 3) in the A ∼ 160 mass region. The dynamic moment of inertia against ħω is also studied. | 2022-07-30T21:16:45.950Z |
95,027,351 | {
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"DOI": "10.1080/01904167.2013.873459",
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} | The aim of this study was to investigate the potential of silicon (Si) for alleviating Ultraviolet-B (UV-B) radiation stress based on changes in biomass, physiological attributes and photosynthetic characteristics of two soybean (Glycine max L.) cultivars, Kenjiandou 43 (‘K 43’) and Zhonghuang 35 (‘ZH 35’). The cultivars were raised with and without Si in the greenhouse, and then subjected to ambient, ambient + 2.7 kJ m−2d−1and ambient + 5.4 kJ m−2d−1of UV-B radiation. Depending on cultivar, plants suffered severe growth limitations under UV-B radiation, but the application of Si alleviated the adverse effects on growth and development by increasing the stem length, net photosynthetic rate (PN) and leaf chlorophyll content. Concurrently, it decreased the stomatal conductance (Sc) and intercellular carbon dioxide (CO2) concentration (Ci). In response to the UV-B radiation stress, the antioxidant enzyme activities of superoxide dismutase (SOD) increased by 41.2–72.7%, peroxidases (POD) by 49.5–85.7%, malodialdehyde (MDA) by 6.7–20.4% and soluble protein by 4.2–7.6%. The overall results indicated that media treatment with Si might improve soybean growth under elevated UV-B radiation through positive changes in biomass and some physiological attributes that were dependent on cultivar. | 2022-12-17T17:36:13.658Z |
218,897,376 | {
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"DOI": "10.1076/0271-3683(200006)2061-YFT496",
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} | Purpose. To determine the transcorneal flux, and intracorneal penetration, of ?9-tetrahydrocannabinol when presented to the isolated rabbit cornea in different vehicles. Methods. Corneas were mounted in specular microscope hambers, with 3 H-?9-tetrahydrocannabinol on the epithelial surface in one of 15 vehicles and the endothelium perfused with Ringer. Following equilibration the perfusate was collected at 20 minute intervals and sampled for counting. After 3 hours the epithelium was harvested and the stroma/endothelium collected. The tissues were placed in distilled water and sampled at 24 hours. Results. The order of efficacy of the best 6 vehicles in terms of transcorneal ?9-tetrahydrocannabinol flux was: a-cyclodextrin > hydroxypropylmethylcellulose (80 to 120 centipoises) > polyvinyl alcohol > hydroxypropylmethylcellulose (3500 to 5600 centipoises) > polyvinylpyrrolidone (29 to 32 centipoises) > polyvinylpyrrolidone (12 to 18 centipoises). Remaining vehicles, including light mineral oil, corn oil, hyaluronic acid, hydroxypropyl-ß-, ß-, and ?-cyclodextrin and hydroxypropylmethylcellulose (40 to 60 centipoises) all gave lower fluxes. The epithelium was the site of most intracorneal drug. Conclusions. Differentiation was made between several potential vehicles for in vivo topical delivery of ?9-tetrahydrocannabinol. The vehicles include cyclodextrins and other excipients such as hydroxypropylmethylcellulose and polyvinylpyrrolidone. There is not a strong relationship between solubility or binding of the lipophilic drug by excipients and transcorneal flux. The most efficacious vehicles provided a considerably greater transcorneal drug flux than light mineral oil which previously had been shown to deliver sufficient topical ?9-tetrahydrocannabinol to reduce intraocular pressure of several species. The new vehicles should permit greater pharmacological sequelae. | 2022-08-30T03:02:54.297Z |
119,944,858 | {
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"ArXiv": null,
"DOI": "10.1063/1.870214",
"MAG": "1972659817",
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} | The role of the turbulence-intensity gradient upon the motion of a bubble is investigated. Isolated bubbles are put into a turbulence field, which is isotropic and decreases exponentially in intensity in the z-direction. Experiments are carried out under microgravity conditions, so that the buoyancy is negligible. Bubbles are observed to move in the z-direction. Their mean velocity is found to result from a balance between the mean-pressure gradient and the Reynolds-stress gradient. | 2022-09-04T07:00:58.852Z |
12,865,172 | {
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"DOI": "10.1109/CASE.2011.6042515",
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} | Supervisory Control Theory (SCT) allows for the automatic synthesis of non-blocking supervisors capable of ensuring all and only those sequences of events that meet the specifications for discrete event systems. For a job shop problem, it's possible to obtain an optimal supervisor capable of satisfying resource, production routine and deadline specifications, as well as of providing all viable scheduling solutions, by using a timed SCT extension. This paper investigates the feasibility of applying SCT to production planning and logistics modeling - applications rendered possible through a method for synthesizing schedules via an innovative approach to resource modeling; through the incremental synthesis of production routines and deadlines; and through a bisection method for minimizing total production time and job-specific lead times. The method is applied to the scheduling of activities at a repair shipyard, namely, the activities of the five main resources involved in the execution of ten job orders. The paper concludes with the presentation of a computational tool developed to integrate production planning and a tool for automatic supervisory synthesis so as to facilitate handling of the interface by users not familiar with SCT. | 2022-09-14T22:33:56.935Z |
216,366,292 | {
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"DOI": "10.2166/washdev.2020.144",
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"status": "GOLD",
"url": "https://iwaponline.com/washdev/article-pdf/10/2/276/713158/washdev0100276.pdf"
} |
Proper treatment of wastewater is key to the achievement of sustainable environmental management. The use of ultraviolet radiation and ultrasound have continued to be considered as some of the best sustainable practices in wastewater purification. However, despite the suitability of the two emerging techniques in sustainably increasing the purification efficiencies of wastewater, their application has not been fully understood, especially in eliminating faecal pathogenic microorganisms. Moreover, their combined potential in the elimination of Escherichia coli resistant genes from wastewater has not been adequately explored. This study was designed to evaluate the potential of individual and combined/integrated ultraviolet radiation and ultrasonic technologies in the removal of antibiotic-resistant E. coli from domestic effluents. There was a statistical difference in the mean log units of sulfonamide resistant E. coli between the different ultraviolet radiation and ultrasonic dosages (P < 0.05), showing that ultraviolet radiation technology was more effective in the removal of both sulfonamide and tetracycline resistant E. coli from the wastewater. However, the integrated ultraviolet radiation-ultrasonic technique was highly efficient and is recommended in the removal of antibiotic resistant E. coli from wastewater. Nonetheless, further studies also need to be performed to further evaluate the disinfection effectiveness on a different bacteria species under continuous operation. | 2022-10-10T15:26:39.166Z |
216,417,061 | {
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"DOI": "10.35239/tariharastirmalari.654693",
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"status": "GOLD",
"url": "https://dergipark.org.tr/tr/download/article-file/1010585"
} | Insanoglu tarihin en eski devirlerinden beri, giyinme ihtiyaci hissetmistir. Oncelikle dis dunyadan korunma amacli olan bu ihtiyac, zaman icerisinde kisinin yasadigi toplum, bulundugu cografya, inanc sistemi vs. gibi etkenlerle sekillenmistir. Toplumlar gelistikce, kiyafetler de degisim ve gelisme gostermistir. Zamanla basit kiyafetlerin yerini, daha suslu ve renkli kiyafetler almis; dokuma, bir zanaat dali olarak toplumlarda kendine yer bulmustur. Diger toplumlarda oldugu gibi, Hitit ulkesinde de dokuma alaninda uzmanlasmis kimseler bulunmaktadir. Ve yine Hititce civi yazili belgelerde bircok kiyafet turu karsimiza cikmaktadir. Hititce civi yazili metinlerde gecen dokuma turlerinden birisi TUGkuressar’dir. TUGkuressar, bir kadin giysisidir. Bu durum, Hititce civi yazili belgelerde acikca ortaya konulmustur. TUGkuressar, Hititce belgelerde bircok farkli metinde karsimiza cikmaktadir. | 2022-10-26T15:34:45.305Z |
137,686,865 | {
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"DOI": "10.5006/0010-9312-25.10.438",
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} | Abstract Information is presented on the response to sensitizing heat treatments of Incoloy 800, Incoloy 825, Carpenter 20 Cb-3, Inconel 600, Inconel 625, and Hastelloy G. None of the alloys investigated was found to be consistently immune to the development of susceptibility to intergranular corrosion as measured by nitric acid and ferric sulfate-sulfuric acid evaluation tests. In most cases the two test methods were in substantial agreement but the ferric sulfate-sulfuric acid test was less sensitive to thermal effects for Incoloy 825 and more sensitive for Hastelloy G. In general, variability in resistance to sensitization as a function of prior processing history appears to be more pronounced in the higher nickel alloys than in the 300 series stainless steels. | 2022-12-11T18:16:19.102Z |
85,039,755 | {
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"DOI": "10.1039/C4TB01903B",
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} | Until now, there has been no appropriate marker to specifically and effectively label living neural stem/precursor cells (NSPCs) to investigate NSPC migration and differentiation. Therefore, the purpose of this study was to develop a specific method for tracking NSPCs by a cell marker, 3,6-bis(1-methyl-4-vinylpyridinium)-carbazole diiodide (BMVC). It was found that the bright fluorescence spots could be rapidly observed in the nuclei of NSPCs, isolated from the embryonic rat cerebral cortex, after incubation with BMVC for just 5 min and could be maintained for exceeding 7 days without obvious decay. Even NSPCs were induced to undergo differentiation; their daughter cells also expressed bright fluorescence spots. In contrast, foreskin fibroblasts, adipose-derived stem cells (ADSCs), bone marrow mesenchymal stem cells (BMMSCs), neurons, and glial cells did not express the bright fluorescence spot in the presence of BMVC. In addition, BMVC-labeled NSPCs could be tracked in wound healing and decellularized rat brain models with minimal cell toxicity. Therefore, BMVC possessed a specific function to distinguish between NSPCs and other stem and neuron-related cells. These results are very encouraging, since a cell marker favorable for long-term labeling NSPCs should be useful in the development of strategies for tracking the development of NSPCs in neuroscience research. | 2022-07-11T20:24:22.226Z |
186,206,668 | {
"externalids": {
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"ArXiv": "1906.04905",
"DOI": "10.1088/1361-6544/ab987e",
"MAG": "3092380835",
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"license": null,
"status": "GREEN",
"url": "http://arxiv.org/pdf/1906.04905"
} | We study the stability of statistical properties of Anosov maps on tori by examining the stability of the spectrum of an analytically twisted Perron–Frobenius operator on the anisotropic Banach spaces of Gouëzel and Liverani (2006 Ergod. Theor. Dyn. Syst. 26 189–217). By extending our previous work in Crimmins and Froyland (2019 Ann. Henri Poincaré 20 3113–3161), we obtain the stability of various statistical properties (the variance of a CLT and the rate function of an LDP) of Anosov maps to general perturbations, including new classes of numerical approximations. In particular, we obtain new results on the stability of the rate function under deterministic perturbations. As a key application, we focus on perturbations arising from numerical schemes and develop two new Fourier-analytic methods for efficiently computing approximations of the aforementioned statistical properties. This includes the first example of a rigorous scheme for approximating the peripheral spectral data of the Perron–Frobenius operator of an Anosov map without mollification. We consequently obtain the first rigorous numerical methods for estimating the variance and rate function for Anosov maps. | 2022-12-18T03:11:13.093Z |
95,144,210 | {
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"DOI": "10.1070/RC1999V068N10ABEH000480",
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} | Methods of synthesis, molecular and electronic structures and
electrophysical, optical and magnetic properties of ternary and quaternary
chalcogenides based on copper, silver and gold are considered. The possibility
of the synthesis of chalcogenide analogues of high-temperature superconductors
is discussed. The prospects of searching for new high-temperature
superconductors in Ln–Cu–X systems, where Ln is a rare-earth element
and X is S, Se or Te, are shown. The bibliography includes 148
references. | 2022-12-20T17:04:45.684Z |
250,857,907 | {
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"DOI": "10.1070/RC2005v074n02ABEH000970",
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} | The review summarises the achievements in the theory of the equation of state. Novel approaches and new high-precision equations of state for one- and multicomponent fluid systems are consdidered. The results are given for both bulk phases and surface monolayers including two-dimensional equations. In the framework of the theory based on the exclusion factor, a hierarchy of approximations is formulated, incorporating both well-established and relatively new equations of state. | 2022-08-25T00:58:16.801Z |
129,915,968 | {
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"DOI": "10.1002/hyp.9760",
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} | Artesian springs are localized aquifer outlets that originate when pressurized ground water is allowed to rise to the surface. Computing artesian discharge directly is often subject to practical difficulties such as restricted accessibility, abundant vegetation or slow flow rates. These circumstances call for indirect approaches to quantify flow. This paper presents a method to estimate ground water discharge through an upwelling spring by means of a three‐layer steady‐state groundwater flow model. Model inputs include on‐site measurements of vertical sediment permeability, sediment temperatures and hydraulic gradients. About 70 spring bed piezometers were used to carry out permeability tests within the spring sediments, as well as to quantify the hydraulic head at different depths below the discharge point. Sediment temperatures were measured at different depths and correlated to permeabilities in order to demonstrate the potential of temperature as a substitute for cumbersome slug tests. Results show that the spatial distribution of discharge through the spring bottom is highly heterogeneous, as sediment permeability varies by several orders of magnitude within centimetres. Sensitivity analyses imply that geostatistical interpolation is irrelevant to the results if field datasets come from a sufficiently high resolution of piezometric records. Copyright © 2013 John Wiley & Sons, Ltd. | 2022-09-01T08:45:18.083Z |
151,798,584 | {
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"DOI": "10.1017/CCOL9780521519373.002",
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} | The opening of John Ford's 1633 play 'Tis Pity She's a Whore raises questions about the connections between the closeness of family ties, the private spaces of the household and the nature of tragedy. It begins with a shocking discussion between Giovanni, son of Florio, a citizen of Parma, and a Friar. Giovanni has 'unclasped [his] burdened soul' and 'Emptied the storehouse of [his] thoughts and heart' about his love, but the Friar is appalled by what he hears (1.1.13-14). The love Giovanni describes is a passionate one for his sister Annabella with whom he goes on to have a relationship that leaves her pregnant, and he tries to justify his feelings to the Friar by explaining the closeness of the relationship between a brother and a sister: Say that we had one father, say one womb / (Curse to my joys) gave both us life and birth; / Are we not therefore each to other bound / So much the more by nature? by the links Of blood, / of reason? nay, if you will have't, / Even of religion, to be ever one, / One soul, one flesh, one love, one heart, one all? (1.1.28-34) The Friar, not surprisingly, does not think much of Giovanni's logic, and rather than appreciating the bonds of a shared parentage as the basis for a sexual relationship, he tells Giovanni that he's damned. | 2022-09-05T22:53:29.520Z |
25,646,349 | {
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"DOI": "10.1243/09544119JEIM489",
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} | Abstract While researchers have suggested that joint mobility would probably be affected by age and gender, research findings often present discrepancies. Little research has been performed on the factors which effect mobility of the trapeziometacarpal (TMC) joint. The purpose of this study was to address the effects of age and gender on the ranges of motion of the normal TMC joint. Eighty normal subjects divided into four age groups participated in this study. The TMC joint motions were recorded using an electromagnetic tracking system. In order to achieve a maximal range of TMC joint motion which was defined as the maximal workspace, each subject was asked to perform actively maximal circumduction, flexion—extension, and abduction—adduction of the TMC joint. Numerical and statistical methods were used to compute the TMC workspace and to detect significant differences. A workspace-to-length ratio was determined as an index to examine the effects of the age and gender on the joint mobility. The results demonstrated that age and gender had significant influences on the TMC workspace among the groups studied. The understanding of TMC joint mobility under different age and gender conditions is achieved through this study. The findings can be used to report clinical measures in the determination of the extent of impairment of osteoarthritis as well as the outcomes between pre- and post-surgical (or non-surgical) interventions. | 2022-09-09T23:55:35.078Z |
25,250,202 | {
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"ArXiv": null,
"DOI": "10.1006/JAUT.1996.0042",
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} | To study the ability of interleukin 1-beta (IL-1) to induce apoptosis in the endocrine pancreas, rat islets of Langerhans obtained from 14-day-old BB.1A rats were exposed to 25 U/ml IL-1 for 40 h. In order to prove the role of nitric oxide (NO) in this process islets were exposed either to 1 mmol/l N-nitro-L-arginine methylester (NAME) or to 25 mmol/l nicotinamide (NA) or to a combination of NA or NAME with IL-1. In dispersed cells oligonucleosomes, resulting from cleavage of nuclear DNA due to apoptosis, were identified by enzymatic labelling the free 3'-OH-DNA ends with fluorescein-dUTP and quantified by means of flow cytometry. After exposure to IL-1, the islets were characterized by elevated basal (in response to 2 mmol/l glucose) insulin release while glucose-stimulated (20 mmol/l glucose) insulin secretion was nearly completely abolished. In contrast, glucose-stimulated insulin secretion was well preserved in NAME-exposed islets, but was markedly inhibited after NA treatment. Accordingly, only the IL-1-induced inhibition of glucose-stimulated insulin secretion was significantly restored in the presence of NAME but was reinforced by NA. IL-1 exposure resulted in a significant increase in the percentage of apoptotic cells (untreated controls 3.8 +/- 0.5% IL-1 18.8 +/- 1.8%, P < 0.01). This effect was significantly reduced in the presence of NA and NAME. Nitrite production which was assayed as an equivalent of NO generation of islets was highest under the influence of IL-1 (16.48 +/- 1.40 versus 2.89 +/- 0.37 pmol/islet for control islets) which was correlated with the percentage of apoptotic cells. IL-1-stimulated nitrite production was reduced to 9.25 +/- 0.48 and 3.41 +/- 0.36 pmol/islet in the presence of NA or NAME, respectively. The results demonstrate the potency of IL-1 to induce apoptosis in rat islets. Since inhibition of NO production was always paralleled by a reduced ability of IL-1 to induce programmed cell death, this radical appears to be involved in this process. Remarkably, the near-complete prevention of NO generation as demonstrated under the influence of NAME was able to prevent the IL-1-induced deterioration of glucose-stimulated insulin secretion in parallel to the prevention of apoptosis-related appearance of DNA double-strand breaks. It is concluded that the elimination of damaged beta cells due to IL-1 exposure is partly achieved by induction of apoptosis. | 2022-09-11T23:03:13.712Z |
243,188,911 | {
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"ArXiv": null,
"DOI": "10.31219/osf.io/wzfmy",
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},
"license": null,
"status": "GREEN",
"url": "https://osf.io/wzfmy/download"
} | Pengaruh bimbingan belajar terhadap prestasi belajar siswa kelas IV SD inpres nipa nipa | 2022-10-07T15:54:18.338Z |
249,941,933 | {
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"DOI": "10.1364/oe.459743",
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"license": "CCBY",
"status": "GOLD",
"url": "https://doi.org/10.1364/oe.459743"
} | Silicon photonic integrated sensors based on microring resonators are a promising candidate to achieve high-performance on-chip sensing. In this work, a novel dual-parameters sensor based on polarization multiplexing on silicon-on-insulator (SOI) platform is proposed and demonstrated experimentally, simultaneously achieving refractive index (RI) and temperature sensing with high sensitivity and large detection range (DR). The experimental results show that the RI sensitivity and temperature sensitivity of the TM-operated sensor are 489.3 nm/RIU and 20.0 pm/°C, respectively, and that of the TE-operated sensor are 102.6 nm/RIU and 43.3 pm/°C, respectively. Moreover, the DR of the fabricated sensor is 0.0296 RIU, which is 4.2 times that of the conventional TM-operated sensor based on the microring resonator. The dual-parameters sensor based on polarization multiplexing can successfully realize the simultaneous measurement of the RI and the temperature, showing potential applications of silicon photonic on-chip sensors in reality. | 2022-10-15T07:28:37.699Z |
245,201,080 | {
"externalids": {
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"DOI": "10.1155/2021/3532935",
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},
"license": "CCBY",
"status": "GREEN",
"url": "https://downloads.hindawi.com/journals/amse/2021/3532935.pdf"
} | The service performance of subgrade depends on the dynamic resilient modulus (MR) of subgrade soils. Meanwhile, due to complicated conditions such as rainfall infiltration, high temperature evaporation, and groundwater level fluctuations, it can be safely said that the humidity state and repeated wetting-drying (WD) cycles affect the MR of subgrade soils. The object of this study is to conduct a series of dynamic triaxial tests after WD cycles to investigate the characteristics of the MR under various factors. The main results are as follows: (i) the MR decreased with the increase of deviator stress and rose with the growth of confining pressure; (ii) the humidification effect caused by the increase in moisture content attenuated the MR; (iii) the accumulation of WD cycles damaged the MR; however the decline rate was gradually retarded until it was stable with WD cycles 5 times; (iv) the satisfactory prediction model for the MR of subgrade soils considering WD cycles was proposed and verified. It is expected that the findings can provide valuable contributions for road engineering. | 2022-04-08T01:30:50.427Z |
188,316,353 | {
"externalids": {
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"DOI": "10.5965/2595034701082011164",
"MAG": "2800376134",
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},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.revistas.udesc.br/index.php/moin/article/download/1059652595034701082011164/7947"
} | Estudo sobre os concursos de dramaturgia para o teatro de animacao, no Brasil, realizados entre os anos de 1970 a 1993, promovidos pelos orgaos nacionais responsaveis pela area cultural no referido periodo. Trata-se de um estudo exploratorio que inclui dados dos concursos, dos autores premiados e apresenta, ainda, as fontes de consulta sobre os respectivos textos dramaticos publicados e encenados. Palavras-Chave: Dramaturgia; teatro de bonecos; concursos; 1977 a 1993. | 2022-04-08T01:24:05.435Z |
210,163,218 | {
"externalids": {
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"ArXiv": null,
"DOI": "10.1055/s-0039-3402505",
"MAG": "2994829453",
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"license": "CCBYNCND",
"status": "HYBRID",
"url": "http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0039-3402505.pdf"
} | Introduction Tendinopathy is a term used to describe a clinical presentation of pain and dysfunction, which, at times, is accompanied by pathologic structural changes in the tendon matrix. Jumper's knee has been studied for some time, however the etiology is still unknown. The deep fibers of the proximal region are the most affected area in tendinopathies affecting the patellar tendon. Ultrasound (US) scanning may have the greatest sensitivity for confirming clinically diagnosed patellar tendinopathy compared with other imaging techniques such as magnetic resonance. Some studies have found that a minimum of six months is required to observe significant structural changes, although other studies reveal that structural changes can be visible in a shorter period of time. Thus, sonography has been used to evaluate quantitative variables such as thickness, echogenicity, texture measures and the internal tendon matrix. Objective The purpose of this study was to evaluate the sonographic behavior of morpho-textural changes of the patellar tendon in professional male volleyball players over a one year season. Material and Methods This is an observational, longitudinal and analytical study. A sample of 66 patellar tendons from 33 volleyball players of the Spanish super league was recruited, with an average of: 28 years, 86kg and 192cm. An ultrasound scan was performed using the Sonosite Titan ultrasound system, L38, 5–10 MHz, with a cross section of 5mm from the lower pole of the patella. Two depths were analyzed: a.39mm: echogenicity, echogenicity variation, circularity, width and thickness. b.24mm: entropy and contrast. Statistical analysis and analysis of variance (ANOVA) was performed for repeated measures and, in addition, the effect size was calculated with Cohen's d. The confidence interval was 95%. SPSS Statistics software was used. Results For textural variables: contrast increased significantly with an average effect size, and entropy showed no significant difference. Circularity was significantly lower. Width was shown to be significantly greater, with an average effect size, while thickness was reduced significantly. Regarding echogenicity, no significant changes were detected and variation in echogenicity did not show significant changes. Conclusions Imaging analysis could be a potential tool to detect changes in the pattern of patellar tendons. Some morpho-textural changes were found in male volleyball players: the textural contrast variable increases significantly throughout the annual season, meaning that the tendon becomes slightly flatter and loses circularity in its transverse section. The entropy and echogenic parameters obtained from the gray-scale histogram did not reveal any significant changes. | 2022-01-27T02:29:16.002Z |
94,218,442 | {
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"DOI": "10.1021/LA970327M",
"MAG": "1967488281",
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} | In this paper, we report the monolayer behavior of pure (5-n-hexadecanoylamino)fluorescein (HDFL) at the air-water interface. The spectroscopic characteristics of pure HDFL films at the air-water interface and the mixed Langmuir-Blodgett (LB) films of HDFL and palmitic acid (PA) deposited on quartz substrates have been studied and compared with the spectroscopic characteristics of HDFL in solution. The absorption and emission spectra of HDFL at the air-water interface were similar to those in polar, protic solvents but completely different in aprotic, apolar solvents. Detailed spectroscopic studies indicate that in protic solvents the fluorescein moieties exist as cations and zwitterions while in nonpolar environments the fluorescein chromophore exists as an inner lactone that is nonfluorescent. Spectroscopic studies of the mixed films of HDFL and PA transferred on quartz substrates provide evidence of aggregation and formation of at least two different aggregated species, one of them being fluorescent while the other is not. The large differences in the spectral characteristics between the monolayers at the air-water interface and the transferred layers indicate the existence ofHDFL moieties in different molecular configurations that are microenvironment dependent. Surface pressure dependent steady-state in situ fluorescence studies confirm that fluorescence quenching of the dye with increasing surface pressure occurs as a result of efficient energy transfer from the fluorescent monomeric species to the aggregates that are likely nonfluorescent and decay therefrom by nonradiative processes. This study establishes that fluoresceinated dyes may be utilized as efficient molecular probes for ascertaining polarity in supramolecular assemblies. | 2022-09-11T09:04:58.533Z |
52,986,666 | {
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"DOI": "10.1097/GOX.0000000000001906",
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} | Summary: Mephedrone is a new synthetic cathinone-derived drug. It is a sympathomimetic drug, and its structure is similar to amphetamines, although its specific pharmacokinetics and metabolism remain unknown. We performed a literature search in PUBMED with the following key words: Mephedrone AND Necrosis AND Hand. No results were found. We performed a second literature search with the following key words: Mephedrone AND Physiopathology AND Side effects, obtaining a total of 7 articles that we read before writing this case report. We will present a case report of a 28-year-old man with distal ischemia in his left hand associated to intra-arterial drug use of mephedrone. The patient ended up having superficial necrosis involving skin and subcutaneous tissue in his thumb, which was treated with wound care. Good quality healing, full range of motion, and normal sensitivity were achieved. There are no previous publications related to any side effects secondary to its intravascular use. The ultimate mechanism producing this distal fingertip necrosis remains undefined. | 2022-11-21T18:43:01.333Z |
41,657,959 | {
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"DOI": "10.1128/JB.69.5.604-605.1955",
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} | B. subtilis and B. circulans, and a narrower range, among those of B. licheniformis and B. megaterium. On the basis of experience with other variations within a species, it might be assumed that certain strains with lower maximum temperatures of growth could, by proper technique, be induced to grow at higher temperatures within the range established for their particular species. Only three of Allen's 10 thermophilic variants, those of B. licheniformis (table 1), seem to fulfill these expectations. They possessed the morphological and physiological characters of B. licheniformis and grew at 55 C, but not at 60 C, within the range of the species. The shift of 7 of the 10 variants, however, from the parent species to entirely different ones casts grave doubt on Allen's interpretation of her work as proof of adaptation of cultures to growth at higher temperatures. | 2022-12-10T09:05:51.630Z |
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