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138,048,912 | {
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"DOI": "10.1117/12.2230165",
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} | Numerical model for simulation of generation process in advanced pulse-periodic high-peak-power picosecond diode-pumped Nd:YAG and Nd:YLF lasers has been developed. The model adequately describes picosecond pulse formation governed by active and passive mode-locking, negative feedback and adjustable loss level in the oscillator cavity. Optical jitter of output pulses attributed to laser generation development from spontaneous noise level was evaluated using statistical analysis of calculation results. In the presented laser scheme, minimal jitter value on the level ~40 ps was estimated. | 2022-12-18T23:57:00.879Z |
143,206,074 | {
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"DOI": "10.1207/S15324834BASP1204_3",
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} | G. Elder's (1969) marketplace theory and Porterfield's (1978) concept of status incongruity were tested as possible explanations for the perceptions of and behavioral propensities toward a Black male-White female couple in a 2(Sex of Subject) x 2(Race of Male) x 2(Status of Male) x 2(Attractiveness of Female) design. Results obtained showed somewhat greater support for the marketplace concept that for the status incongruity concept. While evaluations of the interracial couple were negative overall, Race x Attractiveness interactions obtained allow one to infer that the couple was evaluated based on the perceived equity of the exchange of these variables. The Black male-unattractive White female couple received the best evaluation. By inference, this couple was perceived as an equitable exchange of assets. | 2022-12-20T00:31:44.082Z |
140,694,108 | {
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"DOI": "10.5762/KAIS.2011.12.9.4192",
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} | Abstract Terrestrial LiDAR is a high precision positioning technique to monitor the behavior and change of structures and natural slopes, but it has depended on subjective hand intensive tasks for the classification(surface and vegetation or structure and vegetation) of positioning data. Thus it has a couple of problems including lower reliability of data classification and longer operation hours due to the surface characteristics of various geographical and natural features. In order to solve those problems, the investigator developed a technique of using the NDVI, which is a major index to monitor the changes on the surface(including vegetation), to categorize land covers, combining the results with the terrestrial LiDAR data, and classifying the results according to items. The application results of the developed technique show that the accuracy of convergence was 94% even though there was a problem with partial misclassification of 0.003% along the boundaries between items. The technique took less time for data processing than the old hand intensive task and improved in accuracy, thus increasing its utilization across a range of fields. | 2022-06-18T09:28:26.592Z |
170,909,995 | {
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"DOI": "10.1017/S0036930600043180",
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} | I view the kenosis that it would be more appropriate that Christ did not have an awareness of his own divinity—a point which remains rather vague in the book under review. Like Dr Moule, I would locate 'the beginning' in God (Jn. 1.1) and in the incarnate life (1 Jn. 1.1-3): I wish that he had made more use of his NT expertise to show us the earthly 'origin of Christology' in the life and death of Jesus, behind the experience and interpretation of the early Christians. I hope a systematic theologian may be forgiven the trespass of reviewing a book by a NT scholar. It may perhaps be seen as a quid pro quo in the light of Dr Moule's venture into more systematic discussion of the continuing 'distinctiveness' of Christ in the last chapter of his book. This chapter reproduces an exchange with Dr Haddon Wilmer which had already appeared in the pages of Theology. It is perhaps not unfair to say that the book as a whole suffers rather from being a compilation from earlier material. The result is repetition and some unevenness of detail. We remain grateful, however, for the author's willingness to stand out against fashions among his fellow NT scholars, and for the many stimulating comments which he often throws modestly away between brackets. GEOFFREY WAINWRIGHT (Birmingham) | 2022-08-03T18:23:42.167Z |
4,710,104 | {
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"DOI": "10.1109/ITEC-INDIA.2017.8333823",
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} | In this paper a single-phase modified continuous input current switched boost inverter (SBI) is presented. The proposed inverter is modified version of SBI in which additional inductor and capacitor are switched with classical SBI to obtain high voltage gain. Detailed comparative analysis (considering the voltage, current stresses and component counts) between the proposed and other conventional impedance source inverters are carried out the highlight the advantages of the proposed inverter. Steady state analysis of proposed topology with simulation and experimental verification are discussed with modified PWM in this paper. TMS320F28335 DSP is used for experimental verification of the proposed inverter. | 2022-09-15T04:27:27.973Z |
79,995,491 | {
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"DOI": "10.1590/1981-52712015V39N4E02772014",
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} | ABSTRACT Medical education has been a recent area of study, research and new formulations, influenced by political, pedagogical, cultural and community aspects related to changes in health systems and services. Medical education has been subjected to profound criticisms about the need to diversify the teaching-learning sce-narios to build up new curricula and subjects, enabling insertion into a reflective and dynamic learning process. In view of the complexity of this issue, we indicate the guidelines necessary to progress with the change process of medical training. The study was conducted using the integrative review method. Searches for articles were made with the keywords: “undergraduate education in Medicine” and “primary health care” in the Virtual Health Library, seeking to capture all the articles that address medical training for the Unified Health System (SUS). This search resulted in 14 articles, which constitute the sample of this study. For analysis and discussion of the results, the articles were categorized in terms of their objectives, metho-dologies, references, results, conclusions and recommendations, in two thematic categories: professional training in the SUS and medical education. Analysis of the articles suggests implementing integration of medical training with health services and participation of community organizations. This seems to cons-titute a central challenge in this quest for change in medical training which offers new resources to fund innovative initiatives and programs, in a scope that encompasses students, teachers and health services, and that seeks new strategies, new pedagogical technologies and curricular reforms. | 2022-09-24T17:10:09.945Z |
246,854,338 | {
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"ArXiv": null,
"DOI": "10.15244/pjoes/143301",
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"url": "http://www.pjoes.com/pdf-143301-73210?filename=Study on Optimal Design.pdf"
} | It is important to optimize the design of urban sewage collection pipe networks. In this study, we established a nonlinear programming mathematical model by considering the undetermined engineering system for an urban sewage collection pipe network scheme as the research subject. The model treats the minimum total annual cost of sewage collection pipe networks as the objective function, the head loss at the head and end of the branch and trunk pipes belonging to the trunk pipe section as the coupling constraint, the longitudinal slope of the pipe section, pipe economic flow rate, and optional standard pipe diameter of the division pipe section as the feasible region constraints on the decision variables, and the line scheme for the pipe networks and diameter of the division pipe section as decision variables. We developed an optimization method by combining orthogonal test-based line selection and the decomposition-dynamic programming aggregation method for the large diameter pipe system, which treats the branch and trunk pipes belonging to the trunk pipe section as the test factor, and the line scheme for the branch and trunk pipes belonging to the trunk pipe section as the test level. We considered the regional sewage collection pipe network in Taizhou city as an example to conduct a comparative analysis and verified that the proposed optimization method can solve this type of large system optimization problem rapidly and accurately, thereby providing a theoretical reference for optimizing the design of urban rainwater drainage pipe networks. | 2022-12-02T11:55:22.506Z |
31,484,544 | {
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"DOI": "10.1073/PNAS.56.2.508",
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} | Classical genetic studies have revealed the presence of an inheritance mechanism in chloroplasts and mitochondria which is partially independent of the nuclear genome.", 2 The production of inheritable cytoplasmic changes by UV irradiation,' 3'4 streptomycin,' and dyes which interact with nucleic acids4' 6 implicated DNA in the transmission of cytoplasmic genetic information. The demonstration of Feulgen-positive material in association with mitochondria of DNase-treated fibroblasts,7 in the kinetoplast of trypanosomes,8 and in the plastids of Chlamydomonas' suggested that these organelles contain DNA. The intramitochondrial localization of DNA was strengthened by the electron microscopic demonstration of heavy metal staining, DNase-removable filaments inside the organelle.10 Finally, the demonstration that DNA could be isolated from chloroplasts of higher plants'1 and Chlamydornonas,12 and that this DNA has a buoyant density in CsCl different from that of nuclear DNA, provided the definitive proof of an organellespecific DNA. Mitochondria also contain a DNA of an independent buoyant density as demonstrated in Neurosporal" and chick,'4 and subsequently in a wide variety of other organisms. Little information is available indicating a specific genetic role for cytoplasmic DNA. Since the function of DNA is limited by its size, an accurate determination of the total length of the mitochondrial DNA molecule would provide a probable maximal limit to its genetic capacity. The high susceptibility of DNA to shear in handling makes it very difficult to isolate intact DNA filaments. The likelihood of degradation is markedly reduced, however, if it can be demonstrated that the DNA molecule is circular. This paper presents electron micrographs and measurements which indicate that mitochondrial DNA isolated from mouse liver is a circular molecule having a unique length. Materials and Methods.-I\litochondria were isolated from adult female CF-1 mice by a method similar to that used earlier for isolation of chick mitochondria.'4 Nuclei were prepared according to the method of Widnell and Tata."5 DNA was extracted by the method of Saito and Miura.16 Both mitochondrial and nuclear DNA were further purified by preparative centrifugation. Buoyant density determinations of DNA were made in CsCl on a Spinco analytical ultracentrifuge according to methods presented by Vinograd and Hearst.17 SPO-1 phage DNA of density 1.740 was used as a density reference.'8 Ultraviolet photographs were scanned with a Joyce-Loebl microdensitometer. Denaturation was accomplished by heating solutions containing 50 /Ag/ml DNA in SSC (SSC = 0.15 M NaCl; 0.015 M Na citrate) in a boiling water bath for 10 min, followed by rapid quenching in ice. DNA was renatured in 2 X SSC at 600 for 6 hr. The modified Kleinschmidt technique of Freifelder and Kleinschmidt'9 was used for spreading the DNA. For our study, DNA was suspended at a concentration of 3-6 ,lg/ml in 1 M ammonium acetate containing 0.01 per cent cytochrome c. | 2022-12-15T02:47:10.565Z |
225,247,596 | {
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"DOI": "10.1080/10549811.2020.1803918",
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} | ABSTRACT Biodiversity and productivity are the two most important attributes linked to the functioning of forest ecosystems. Understanding how diversity and productivity of a forest ecosystem change at a regional scale is crucial for conservation priority. We present an investigation of the structural attributes of forest with respect to biodiversity and biomass through a case study of Dachigam National Park (DNP), a protected forest in Indian Kashmir Himalaya. Systematic random sampling was performed in 60 forest stands of five different forest types of the study region. To compare the biodiversity and biomass attributes among forest types, we used Gaussian error distribution followed by the chi-square Wald test. We estimated structural attributes of the forest to visualize how they relate to the changing biodiversity across different forest types within DNP. The highest values of aboveground, below ground and total biomass were found in Pinus wallichiana forest, while it was lowest in scrub forest. Pinus wallichiana and Quercus robur tree species stocked the largest amounts of biomass, 24.83% and 17.20% respectively, and is a dominant carbon sink. The study would assist in evaluating the forested ecosystems by considering two important attributes of forests represented by diversity and productivity. | 2022-12-16T08:55:32.825Z |
6,269,741 | {
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"DOI": "10.1242/jcs.01030",
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} | The GABA-synthesizing enzyme GAD65 is synthesized as a soluble cytosolic protein but undergoes post-translational modification(s) to become anchored to the cytosolic face of Golgi membranes before targeting to synaptic vesicle membranes in neuroendocrine cells. Palmitoylation of cysteines 30 and 45 in GAD65 is not required for targeting to Golgi membranes but is crucial for post-Golgi trafficking to presynaptic clusters in neurons. Here, we show that palmitoylated GAD65 colocalizes with the small GTP-binding protein Rab5a in Golgi membranes and in axons but not in dendrites. In the presence of the constitutively positive mutant Rab5(Q79L) palmitoylation resulted in polarized targeting of GAD65 to giant Rab5a-positive axonal endosomes, characterized by the absence of the Rab5a-effector molecule EEA1 and the transferrin receptor. By contrast, Rab5a-positive/EEA1-positive somatodendritic giant endosomes containing the transferrin receptor were devoid of GAD65. Palmitoylation-deficient GAD65 was excluded from endosomal compartments. A dominant negative mutant of Rab5a, Rab5a(S34N), specifically blocked axonal trafficking and presynaptic clustering of palmitoylated GAD65, but did not affect axonal trafficking of mutants of GAD65 that fail to traffic to giant axonal endosomes containing Rab5a(Q79L). Two transmembrane synaptic vesicle proteins, VAMP2 and VGAT also localized to the axonal giant endosomes, and their axonal trafficking and presynaptic clustering was blocked by Rab5a(S34N). The results suggest that palmitoylation of GAD65 regulates the trafficking of the protein from Golgi membranes to an endosomal trafficking pathway in axons that is dependent on Rab5a and is required for the targeting of several synaptic vesicle proteins to presynaptic clusters. | 2022-12-19T00:29:40.847Z |
53,038,027 | {
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"DOI": "10.1145/3240508.3240560",
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} | Cross-modal hashing aims to learn hash functions, which map heterogeneous multimedia data into common Hamming space for fast and flexible cross-modal retrieval. Recently, several cross-modal hashing methods learn the hash functions by mining the correlation among multimedia data. However, they ignore two properties of cross-modal data: 1) The features of different scale in single modality consist different information, such as texture, object and scene feature in the image, which can provide multi-scale information on retrieval task. 2) The correlation among the features of different modalities and scales can provide multi-scale relationship for better cross-modal hashing learning. In this paper, we propose Multi-scale Correlation Sequential Cross-modal Hashing Learning (MCSCH) approach. The main contributions of the MCSCH can be summarized as follows: 1) We propose a multi-scale feature guided sequential hashing learning method which sequentially generates the hash code guided by different scale features through a RNN based network. The multi-scale feature guided sequential hashing learning method utilizes the scale information, which enhances the diversity of the hash codes and reduces the error caused by extreme situation in specifc features. 2) We propose a multi-scale correlation mining strategy during the multi-scale feature guided sequential hashing learning, which can simultaneously mine the correlation among the features of different modalities and scales. Through this strategy, we can mine any pair of scale features in different modalities and obtain abundant scale correlation for better cross-modal retrieval. Experiments on two widely-used datasets demonstrate the effectiveness of our proposed MCSCH approach. | 2022-12-21T04:17:02.689Z |
2,507,444 | {
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"DOI": "10.3390/nu9040328",
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"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2072-6643/9/4/328/pdf?version=1490436529"
} | Vitamin D deficiency (<20 ng/mL) and insufficiency (20–29 ng/mL) are common among patients with chronic kidney disease (CKD) or undergoing dialysis. In addition to nutritional and sunlight exposure deficits, factors that affect vitamin D deficiency include race, sex, age, obesity and impaired vitamin D synthesis and metabolism. Serum 1,25(OH)2D levels also decrease progressively because of 25(OH)D deficiency, together with impaired availability of 25(OH)D by renal proximal tubular cells, high fibroblast growth factor (FGF)-23 and decreased functional renal tissue. As in the general population, this condition is associated with increased morbidity and poor outcomes. Together with the progressive decline of serum calcitriol, vitamin D deficiency leads to secondary hyperparathyroidism (SHPT) and its complications, tertiary hyperparathyroidism and hypercalcemia, which require surgical parathyroidectomy or calcimimetics. Kidney Disease Outcomes Quality Initiative (KDOQI) and Kidney Disease Improving Global Outcomes (KDIGO) experts have recognized that vitamin D insufficiency and deficiency should be avoided in CKD and dialysis patients by using supplementation to prevent SHPT. Many vitamin D supplementation regimens using either ergocalciferol or cholecalciferol daily, weekly or monthly have been reported. The benefit of native vitamin D supplementation remains debatable because observational studies suggest that vitamin D receptor activator (VDRA) use is associated with better outcomes and it is more efficient for decreasing the serum parathormone (PTH) levels. Vitamin D has pleiotropic effects on the immune, cardiovascular and neurological systems and on antineoplastic activity. Extra-renal organs possess the enzymatic capacity to convert 25(OH)D to 1,25(OH)2D. Despite many unanswered questions, much data support vitamin D use in renal patients. This article emphasizes the role of native vitamin D replacement during all-phases of CKD together with VDRA when SHPT persists. | 2022-12-25T23:05:23.658Z |
99,599,330 | {
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"DOI": "10.1021/ACS.JPCC.5B02284",
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} | We present a Raman spectroscopy investigation of the vibrational properties of a rare-earth endohedral metallofullerene, Gd@C82, at low temperatures. While lowering the temperature, the Raman spectra show a blueshift in the Gd–C and C–C vibrational modes which are attributed to both anharmonic and thermal expansion contributions in the fullerene cage. The experimental data are compared with the theories of the shift and broadening of the phonon lines, and respective anharmonic and temperature coefficients are evaluated. In addition, the force constant of the Gd–C82 vibration is derived at various temperatures using a linear harmonic oscillator model. No change in the oxidation state of the ion is noted in the examined temperature range. | 2022-12-30T19:17:49.585Z |
226,648,814 | {
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"DOI": "10.37360/BLACPMA.20.19.2.12",
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} | The present study aimed to screen the Rhazya stricta Decne root for its antihyperglycemic and antioxidants potential through in-vitro assays along with phytochemical and elemental analyses. The crude extract was prepared through maceration and fractionated using solvent-solvent extraction technique. The spectroscopic studies indicated the presence of various phytochemical classes in the extract and its fractions. The antioxidant assays showed notable results along with a good concentration of phenolic and flavonoid contents. Enzyme inhibition assays demonstrated glucose-lowering effects by inhibiting the enzyme activity which could reduce post-prandial blood glucose level. The Dipeptidyl peptidase-IV (DPP-IV) inhibition assay results showed the novel DPP-IV inhibition activity of the plant extract and all fractions showed noteworthy enzyme inhibition and antihyperglycemic activity. Conclusively, the Rhazya stricta root extract displayed its antioxidant and antihyperglycemic potential due to the presence of various classes of phytochemicals and micro-nutrients. | 2022-01-27T11:05:45.942Z |
155,407,435 | {
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"DOI": "10.32682/jeel.v4i1.721",
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} | The scenes in the trailer shown are all sorts of interesting and prominent scenesto attract the attention of potential viewers and be able to describe the entire contents of the movie without giving too much information. The trailer was created to promote theatrical release of the movie and the movie trailer was a clip containing all the parts of the advertised movie, shown before other movie screenings in the cinema, and aimed for the audience to come to watch. The best way to teach English is to use interesting material, appropriate teaching methods, the use of technology that can be one of the important and effective support tools. Meta-analysis is essentially a synthesis of a topic taken from several research reports. Based on the synthesis is drawn conclusions about the topic under study. This research uses some similar research results as basic data in conducting studies and conclusions. From the same five studies, it is concluded that Movie Trailer is effective as a learning medium because it can improve understanding in English learning. | 2022-02-09T01:20:13.384Z |
10,873,328 | {
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"ArXiv": null,
"DOI": "10.1292/JVMS.58.10_1011",
"MAG": "2325835266",
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} | Isolation of very virulent Marek's disease virus (vvMDV) was carried out by inoculating blood and spleen samples of Marek's disease (MD) chickens onto chicken embryo fibroblast cell cultures and into the peritoneal cavity of one-day-old chicks. Seven isolates of MDV were isolated in this experiment. By the results of cytopathic effect and fluorescent antibody tests, the 7 isolates were divided into 3 serotypes: serotype 1 of strains LTB-1, -2, -3, LTS-1, and -2; serotype 2 of strain LTB-4; and serotype 3 of strain LTB-5. Strain LTB-1 was used to inoculate experimental chickens of both layers and broilers. Early phase mortality and markedly atrophied lymphoid organs were observed during 0-2nd week post-inoculation (PI) and at 5th week PI, respectively, but were not found in uninoculated chickens. In addition, experimental chickens vaccinated with (HVT) vaccine at 1 day old and challenged with strain LTB-1 at 10th day post-vaccination, revealed early phase death before 2nd week post-challenged (PC), and lymphomatous lesions before 10th week PC. From these results of this in vivo experiment, strain LTB-1 showed the same pathogenicity as that of vvMDV, and this is the first report of vvMDV being isolated and identified in Taiwan. | 2022-02-13T05:48:22.519Z |
73,109,970 | {
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"DOI": "10.11144/JAVERIANA.UO33-71.FEAT",
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} | Antecedentes: los errores clinicos en la prestacion de servicios de salud pueden deteriorar mas la salud de un paciente. El sistema de salud de paises como Colombia establece la obligatoriedad de reportar y hacer seguimiento de tales eventos adversos. Proposito: determinar la frecuencia y la naturaleza de los eventos adversos identificados en las historias clinicas de pacientes que asistieron al Posgrado de Endodoncia de la Pontificia Universidad Javeriana en Bogota Colombia (2007-2008) y describir el seguimiento realizado a los casos reportados en el primer periodo del 2007. Metodos: en este estudio descriptivo se analizaron 464 historias clinicas en las que se identificaron eventos adversos de tratamientos endodonticos en la hoja de evolucion, la secuencia radiografica y la confirmacion en el sistema (modelo se identificacion y seguimiento de eventos adversos). Dichos eventos pudieron ocurrir en los procedimientos de apertura, preparacion, obturacion y despues del tratamiento. Resultados: se encontraron 306 eventos adversos en endodoncia (74,4 %). De ellos, 81,3 % eran eventos prevenibles en procedimientos apertura (4,1 %), preparacion (36,1 %) y obturacion (60 %). Las perforaciones coronales, transportaciones y sobreobturaciones fueron los mas frecuentes, respectivamente, en cada tipo de procedimiento. Por otra parte, se identificaron signos de enfermedad en un 26,3 % de los casos de seguimiento analizados del primer periodo del 2007. Conclusion: dada la alta frecuencia de eventos adversos prevenibles en endodoncia identificados en este estudio, es importante generar mecanismos para determinar las causas y generar estrategias para disminuirlas. Background: Clinical errors in health care can complicate even more a patient’s health. In health care systems such as the Colombian it is compulsory to report and follow up such adverse events. Purpose: Describe the frequency and nature of adverse events identified in the clinical records of patients who attended the Endodontics Postdoctoral Clinics of the Pontificia Universidad Javeriana in Bogota Colombia (2007-2008) and to describe the follow-up reported cases from the first period of 2007. Methods: In this descriptive study, the follow-up chart, radiographic records, and registry in the system (adverse event identification and follow-up model) of 464 clinical records were analyzed to identify adverse events associated with endodontic therapy. Those events could have happened during root canal opening, clean-up/shaping, filling, and post-treatment. Results: There were 306 adverse events related to endodontic treatment (74.4%). 81.3% were preventable events during canal opening (4.1%), clean-up/shaping (36.1%), and filling (60%). Crown perforations, root canal transportation, and overfilling were the most frequent events in the procedures mentioned before. On the other side, there were symptoms reported in 26.3% of the 2007 first-term follow-up cases studied. Conclusion: Since adverse events in endodontics identified in this study were very frequent, it is important to create mechanisms to determine causes and develop strategies to reduce them. | 2022-03-08T13:27:24.347Z |
136,669,601 | {
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"DOI": "10.1115/MSEC2014-4035",
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} | A process for surface finishing of medical device and implant alloys is described. Unlike conventional electrochemical surface finishing processes, Faraday’s pulse reverse process does not require low conductivity/high viscosity electrolytes and does not require the addition of aggressive chemicals such as hydrofluoric acid to remove the passive film associated with electropolishing of passive and strongly passive materials. This paper focuses on pulse/pulse reverse electropolishing of Nitinol and other metals and alloys containing titanium, molybdenum and niobium.Copyright © 2014 by ASME | 2022-02-09T11:01:01.393Z |
78,257,158 | {
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"DOI": "10.1200/JCO.2008.26.15_SUPPL.19137",
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} | 19137 Background: Pemetrexed (LY231514, MTA) is a novel, multitargeted antifolate chemotherapy agent that has demonstrated clinical activity in non-small cell lung cancer as well as other solid tumors. In non-small cell lung cancer, single-agent activity has been documented in the first- and second-line settings in Phase II and Phase III trials. Based on these results, treatment with pemetrexed would be considered a standard treatment option for second-line NSCLC. Thus, this prospective, multicenter, phase II study assessed the efficacy and safety of pemetrexed in patients with advanced NSCLC who had prior chemotherapy in Korea. Methods: Patients ≥ 18 years with a histologic/cytologic diagnosis and who have had prior chemotherapy for advanced non-small cell lung cancer received pemetrexed at 500 mg/m2 every 3 weeks with folic acid and Vitamin B12 supplementation. Up to 72 patietns were to be enrolled as a Simin two- stage optimal design. Results: From June 2006 to April 2007, 81 patients with stage IIIB a... | 2022-02-11T04:57:22.026Z |
240,510,160 | {
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"DOI": "10.15517/AIE.V21I2.46785",
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} | En Mexico, la obligatoriedad de la Educacion Media Superior decretada en 2012 todavia es tarea pendiente en los contextos rurales y conurbados en donde los Telebachilleratos Comunitarios son una politica educativa en expansion para incorporar jovenes antes excluidos del sistema escolar. El Telebachillerato tiene sus origenes en 1980, no obstante, la modalidad escolarizada y comunitaria cuenta con apenas cinco generaciones, y aun es escasa la investigacion desde la perspectiva de sus propios actores. Por esta razon, el presente estudio se propuso comprender como las condiciones de acceso a este tipo educativo signan las subjetividades juveniles y su experiencia escolar. El estudio de corte cualitativo-interpretativo se desarrollo al sur del estado de Mexico, durante el bienio noviembre 2018-2020, bajo una metodologia dialogico-reflexiva desplegada en un taller de narrativa con un grupo de sexto semestre. Las sesiones fueron videograbadas, transcritas y sistematizadas en tres lineas analiticas: condiciones de acceso a la escolaridad, subjetividades juveniles y participacion en la escuela. Los resultados visibilizan itinerarios escolares marcados por la implementacion precaria de una modalidad en donde la poblacion de jovenes se enuncia a si misma como la mas abatida, pero en la que tambien construye otros modos de subjetividad a traves de la participacion para demandar mejor infraestructura, incidencia en la normatividad escolar y procesos pedagogicos basados en el reconocimiento. Se concluye que las subjetividades y narrativas escolares son fundantes de comunidades educativas construidas en el dialogo reflexivo y emergentes sentidos juveniles que se ponen en juego en el ejercicio del derecho a la educacion. | 2022-07-09T05:12:28.021Z |
154,152,909 | {
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"DOI": "10.1080/01900692.2013.791310",
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} | Although research on private-sector expatriates is abundant, not much is known about their public-sector counterparts, especially self-initiated expatriates, who themselves initiate the move to live and work abroad. Comparing work outcomes and creativity of self-initiated expatriates in the private vs. the public sector, the results of a survey including 329 respondents indicated that performance and effectiveness were higher in the private sector. However, only in the public sector was there a positive association between creativity and the two work outcomes. These findings are discussed in detail. | 2022-12-03T22:40:30.614Z |
61,778,235 | {
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"DOI": "10.1109/WSC.2003.1261603",
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} | Research was undertaken to assist practitioners in undertaking Monte Carlo simulation of project schedules. A probabilistic model was developed to translate project characteristics into schedule risk boundaries. This model has been tested in several projects and performed very well. Lessons learned during the application of Monte Carlo simulation to a large project are discussed. | 2022-12-05T17:12:30.599Z |
15,174,593 | {
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"DOI": "10.1145/2983468.2983516",
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"status": "BRONZE",
"url": "http://dl.acm.org/ft_gateway.cfm?id=2983516&type=pdf"
} | The paper presents a formal model for generation of personalized learning paths. The paths consist of self-modifying learning activities suitable for the achievement of course goals. The course goals (as defined by the teacher) are a list of functions/predicates with specific slots and include obligatory activities required for the automatized construction of learning paths. Further, the problems related to automatized learning path construction are identified and solved with the use of an original approach. The approach includes (but is not limited to): introduction of different points of view (aspects) for learning objects; automatized gathering/accumulation of metadata for learning activities; generation of personalized learning paths using set of student achievements, etc. | 2022-12-12T14:22:08.889Z |
218,858,955 | {
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"DOI": "10.3390/ijms21103621",
"MAG": "3026584115",
"PubMedCentral": "7279318"
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"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/1422-0067/21/10/3621/pdf?version=1590463803"
} | Prodrugs are designed to improve pharmaceutical/biopharmaceutical characteristics, pharmacokinetic/pharmacodynamic properties, site-specificity, and more. A crucial step in successful prodrug is its activation, which releases the active parent drug, exerting a therapeutic effect. Prodrug activation can be based on oxidation/reduction processes, or through enzyme-mediated hydrolysis, from oxidoreductases (i.e., Cytochrome P450) to hydrolytic enzymes (i.e., carboxylesterase). This study provides an overview of the novel in silico methods for the optimization of enzyme-mediated prodrug activation. Computational methods simulating enzyme-substrate binding can be simpler like molecular docking, or more complex, such as quantum mechanics (QM), molecular mechanics (MM), and free energy perturbation (FEP) methods such as molecular dynamics (MD). Examples for MD simulations used for elucidating the mechanism of prodrug (losartan, paclitaxel derivatives) metabolism via CYP450 enzyme are presented, as well as an MD simulation for optimizing linker length in phospholipid-based prodrugs. Molecular docking investigating quinazolinone prodrugs as substrates for alkaline phosphatase is also presented, as well as QM and MD simulations used for optimal fit of different prodrugs within the human carboxylesterase 1 catalytical site. Overall, high quality computational simulations may show good agreement with experimental results, and should be used early in the prodrug development process. | 2022-12-12T17:09:27Z |
55,427,727 | {
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"DOI": "10.1127/0935-1221/2007/0019-1720",
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"status": "CLOSED",
"url": null
} | Pumpellyite-(Al), ideally Ca 2 (Al,Fe 2+ ,Mg)Al 2 (SiO 4 )(Si 2 O 7 )(OH,O) 2 ·H 2 O, is a newly approved mineral species from Bertrix, Ardennes mountains, Belgium. It occurs as radiating fibrous aggregates reaching 5 mm in diameter, constituted by acicular crystals associated with calcite, K-feldspar and chlorite. Pumpellyite-(Al) is transparent to translucent and exhibits an emerald-green to white colour, sometimes with bluish tinges. The lustre is vitreous and the streak is colourless. The mineral is non-fluorescent, brittle, and shows a perfect {100} cleavage. The estimated Mohs hardness is 5½, and the calculated density is 3.24 g/cm 3 . Pumpellyite-(Al) is biaxial positive, α = 1.678(2), β = 1.680(2), γ = 1.691(1) (λ = 590 nm), colourless in thin section, 2 V = 46°, Y = b , no dispersion. Electron-microprobe analyses gave SiO 2 37.52, Al 2 O 3 25.63, MgO 1.99, FeO 4.97, MnO 0.11, CaO 23.21, BaO 0.01, Na 2 O 0.03, K 2 O 0.02, H 2 O calc . 6.71, total 100.20 wt. %. The resulting empirical formula, calculated on the basis of 8 cations, is (Ca 1.99 Na 0.01 ) ∑2.00 (Al 0.42 Fe 2+ 0.33 Mg 0.24 Mn 0.01 ) ∑1.00 Al 2.00 (SiO 4 )(Si 2 O 7 )(OH) 2.42 0.58H 2 O. The simplified formula is Ca 2 AlAl 2 (SiO 4 )(Si 2 O 7 )(OH) 3 , which requires SiO 2 38.16, Al 2 O 3 32.38, CaO 23.74, H 2 O 5.72, Total 100.00 wt. %. The unit-cell parameters, refined from X-ray powder diffraction data, are: a = 8.818(2), b = 5.898(2), c = 19.126(6) A, β = 97.26(3)°, V = 986.7(4) A 3 , space group A 2/ m. The eight strongest lines in the powder pattern [ d- values(in A)( I )( hkl )] are: 4.371(65)(200), 3.787(80)(202), 3.040(70)(204), 2.912(95)(300), 2.895(100)(302), 2.731(40)(206), 2.630(35)(311), 2.191(45)(402). Pumpellyite-(Al) belongs to the pumpellyite group, and corresponds to the Al-rich compositions where the M1 and M2 sites contain Al as predominant cation. The crystal structure of pumpellyite-(Al) has been refined by the Rietveld method, based on an X-ray powder diffraction pattern, to R Bragg = 7.09 %. The infrared spectrum is similar to those of minerals of the pumpellyite group. The mineral species and name were approved by the Commission on New Minerals and Mineral Names, IMA (no. 2005-016). | 2022-12-12T21:25:18.551Z |
145,797,180 | {
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"ArXiv": null,
"DOI": "10.1002/PITS.21824",
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} | Peer victimization is a concern because victimized youth are more likely to have social, emotional, and academic difficulties. The current study examined the link between peer victimization and academic achievement by exploring the indirect effect of academic self-concept on two variables. The sample consisted of 140 middle school students (40% male, 60% female). Using structural equation modeling, a mediation model revealed a significant indirect effect of victimization on academic achievement through academic self-concept; however, when tested for gender differences, the indirect effect was only significant for girls. Interpretation of these results and suggestions for future studies are discussed. | 2022-12-17T16:37:06.634Z |
155,997,126 | {
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"ArXiv": null,
"DOI": "10.6084/M9.FIGSHARE.1488586.V1",
"MAG": "2222519075",
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} | Teacher education is the corner stone for improving quality of education in India. The teacher education programs have to take the first step towards realizing this goal and provide highly trained teachers who are capable of taking on the challenges of the present and the future. The most immediate transformation that the education system is undergoing today is the blending in of educational technology for the purpose of teaching and learning. One of the dimensions of educational technology is online learning technology and student teachers * should be prepared to integrate it into their teaching and learning practices (Sang, Valcke, van Braak, & Tondeur, 2010)[1]. There is a vast array of online learning resource that the student teachers can freely access and benefit from. Having at least a familiarity with online learning environments is extremely essential for the student teachers not only during their pre-service training but also for their in-service trainings in the future to be in the mainstream of the requirements of the changing society. There is also tremendous scope for them to use online learning environments for teaching purposes. However, their access and exposure to these resources seems to be very limited. This study analyzes the extent to which the student teachers are aware of the online resources and are able to use it for the teaching and learning purposes. It highlights the present status of the teacher training programs regarding their knowledge and involvement with online learning technology. | 2022-08-30T01:35:55.741Z |
34,230,926 | {
"externalids": {
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"ArXiv": null,
"DOI": "10.1109/68.313063",
"MAG": "2152170026",
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} | 100 MHz-bandwidth response of an all-fiber phase modulator composed of a single-mode optical fiber jacketed with a 10 /spl mu/m-thick vinylidene fluoride/trifluoroethylene copolymer, radially poled is presented. Multiple peaks of optical phase shifts induced are observed over the frequency range of 10-100 MHz and ascribed to radial resonances of a fiber-jacket composite. The theoretical analysis of phase shifts is performed based on vibration theory of elasticity taking the exact geometry and composition of the cylindrical multilayer structure into account. The analysis also shows that the phase modulation is strongly dependent on jacket thickness and the maximum induced phase shift will be obtained in the 100 MHz region when the jacket is chosen to be thin as 0.7 /spl mu/m.<<ETX>> | 2022-09-14T01:26:51.354Z |
253,228,243 | {
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"ArXiv": null,
"DOI": "10.25130/tjas.21.2.10",
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},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.tjas.org/index.php/tjas/article/download/97/187"
} | Safflower (Carthamus tinctorius L.) is an annual oil crop that belongs to the Asteraceae family. The experimental studies were conducted at two different research stations in the Kurdistan Regional of Iraq to determine various liquid NPK application methods on the growth, yield, and yield components of three safflower varieties. The experimental design was a complete block design under split-plot system with three replications. NPK application methods (Foliar, Fertigation, Foliar + Fertigation) and no fertilizer application are the main plots. While three safflower varieties (Iden, AL-Shamia, and Zaafarani) as sub-plots. Foliar NPK application had the highest dry matter yield and seed yield of 29.544ton ha-1 and 7.185ton ha-1, respectively, at the average of both locations. Zaafarani safflower variety recorded the maximum dry matter yield and seed yield of 22.204ton ha-1 and 4.794ton ha-1, respectively, at the average of both locations. However, the statistical analysis for both locations' average shows non-significant differences between Iden and Zaafarani varieties have the highest performance for seed yield under foliar NPK application. Based on the average effectiveness of the different methods of applying NPK and safflower varieties on most components of growth, yield, and yield components, the order was as follows: Foliar > Foliar + Fertigation > Fertigation > Control. While for safflower varieties, it was as follows: Zaafarani > Iden > AL-Shamia. The results indicated that the number of capitula plant-1 is an essential character in safflower's seed yield. | 2022-11-04T00:27:50.738Z |
238,684,700 | {
"externalids": {
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"DOI": "10.21203/rs.3.rs-689510/v1",
"MAG": "3189557411",
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},
"license": "CCBY",
"status": "GREEN",
"url": "https://www.researchsquare.com/article/rs-689510/latest.pdf"
} |
Background Sarcopenia is one of the most common syndromes in the older adults. Gastrointestinal tumor is a malignant disease with high incidence. This study aimed to investigate the risk factors of sarcopenia in older adults with gastrointestinal tumor, the prognostic indicators of and short-term outcomes after resection for gastrointestinal tumor, and to explore the relationship between sarcopenia and short-term postoperative prognosis.Method A total of 247 older patients with gastrointestinal tumors who underwent radical resection in 2019 were included in this study. Relevant indexes were calculated using L3 slice image of computed tomography (CT) to evaluate sarcopenia. Short-term postoperative complications and length of stay were considered as short-term outcome of this study.Results Advanced age, lower higher body mass index (BMI), lower hemoglobin, having history of abdominal surgery and higher visceral fat index (VFI) were risk factors of sarcopenia, while higher BMI and lower subcutaneous fat index (SFI) were protective factors of sarcopenia. Further multivariate logistic regression analysis showed that having history of abdominal surgery, advanced age and lower BMI were independent risk factors. Sarcopenia and higher Charlson comorbidity index were independent risk factors of short-term postoperative complications in the elderly with gastrointestinal tumor. Higher Charlson comorbidity index gave rise to longer length of stay.ConclusionsSarcopenia and higher Charlson comorbidity index predict poor short-term prognosis of older patients undergoing gastrointestinal tumor resection. | 2022-12-19T10:15:12.608Z |
235,484,226 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/ijerph18126564",
"MAG": null,
"PubMedCentral": "8296318"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/1660-4601/18/12/6564/pdf?version=1624012464"
} | Sexting is generally known as creating, sending and/or forwarding of sexual content using electronic devices. When such content is non-consensually disseminated, it becomes a criminally relevant behavior. To date, very few empirical studies have examined the prevalence of non-consensual dissemination of sexting, and none of them have analyzed the relationship with psychopathology and further victimization outcomes. Therefore, the aims of this study were (1) to examine the prevalence of non-consensual dissemination of sexual content, (2) to analyze the prevalence of further victimization as a result of non-consensual dissemination of sexting and (3) to investigate the association between secondary victimization as a result of non-consensual dissemination of sexting and psychopathology. The sample comprised 1370 Spanish college students (73.6% female; mean age = 21.4 years; SD = 4.85) who answered an online survey about their engagement in sexting behaviors, online sexual victimization and psychopathology, measured by a sexting scale and the Listado de Síntomas Breve (LSB-50), respectively. Overall, 43 participants (3.14) were victims of non-consensual dissemination of sexting, and results showed those participants who had suffered further victimization reported higher psychopathology scores than those who were not victimized and that being victimized by an ex-partner was associated with poorer mental health outcomes in the victim. Further implications are discussed. | 2022-12-16T15:25:05.765Z |
12,699,726 | {
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"ArXiv": null,
"DOI": "10.1111/J.1745-7262.2007.00283.X",
"MAG": "2135782435",
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},
"license": null,
"status": null,
"url": null
} | Rat protein DE is an androgen-dependent cysteine-rich secretory protein (CRISP) synthesized by proximal epididymal regions. DE, also known as CRISP-1, is localized on the equatorial segment of acrosome-reacted spermatozoa and participates in gamete fusion through binding to egg complementary sites. Immunization of rats with DE inhibits fertility and sperm fusion ability, suggesting that DE represents a good epididymal contraceptive target. Recombinant DE fragments and synthetic peptides revealed that DE binds to the egg via a 12-amino acid region of an evolutionarily conserved motif, Signature 2 (S2). The ability of other CRISP to bind to the rat egg was correlated with their S2 amino acid sequences. Although testicular protein Tpx-1 (CRISP-2) was capable of binding to rodent eggs, human epididymal AEG-related protein (ARP) and helothermine (from lizard saliva) were not. The S2 region presented only two substitutions in Tpx-1 and four in ARP and helothermine, compared with the DE S2, suggesting that this amino acid sequence was relevant for egg interaction. Studies with Tpx-1 and anti-Tpx-1 revealed the participation of this protein in gamete fusion through binding to complementary sites in the egg. In competition studies, DE reduced binding of Tpx-1 dose-dependently, indicating that both CRISP share the egg complementary sites. That anti-DE and anti-Tpx-1 inhibit sperm-egg fusion while recognizing only the corresponding proteins, suggests functional cooperation between these homologous CRISP to ensure fertilization success. These results increase our understanding of the molecular mechanisms of gamete fusion and contribute to the development of new and safer fertility regulating methods. | 2022-12-17T10:25:34.552Z |
29,456,522 | {
"externalids": {
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"ArXiv": null,
"DOI": "10.1021/AC00095A013",
"MAG": "2049036570",
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} | Electrospray ionization mass spectrometry was used for the determination of calcium-binding stoichiometry for calcium-binding proteins. Bovine calmodulin, bovine alpha-lactalbumin, and rabbit parvalbumin were found to bind specifically to 4, 1, and 2 Ca(2+) ions, respectively, in agreement with previously reported results obtained by using other physical methods. This mass spectrometry method could also be applied to proteins that bind more than one type of metal ion. The Zn(2+)- and Ca(2+)-binding stoichiometries for human stromelysin catalytic domain were determined to be 3 and 2, respectively. | 2022-12-21T03:33:22.168Z |
157,409,536 | {
"externalids": {
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"ArXiv": null,
"DOI": "10.1504/IJDIPE.2016.10002292",
"MAG": "2566481901",
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},
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"url": null
} | According to the EU Treaties, the EU economic policy coordination should serve the objectives of the EU, among which is the promotion of the EU values. The paper demonstrates that: a) the EU values and objectives as well as the Charter of Fundamental Rights are binding on the EU institutions, even when they are acting outside the EU legal order (e.g., when drafting the MoUs); b) democratic principles are lacking in the EMU patchwork, especially in the case of member states under adjustment programmes; c) the national constitutional courts have recently ruled that equality and dignity were infringed by the laws implementing the MoUs, and so did the European Committee of Social Rights as far as social rights are concerned. However, the European Court of Human Rights rules that the right to property is not infringed, while the EU Court of Justice denies competence to rule on the MoUs. Such approaches undermine the European citizenship project, and thus European integration. | 2022-02-09T00:16:46.960Z |
10,955,260 | {
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"ArXiv": null,
"DOI": "10.1109/ICBBE.2009.5162464",
"MAG": "2101430766",
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},
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"url": null
} | Perfluorocarboxylates (PFCAs) are the subject of increasingly intense environmental research due to their persistence, bioaccumulation, toxicity, and global distribution. In order to determine wide chain length PFCAs simultaneously, weak anion exchange (WAX) cartridges have recently been used for solid phase extraction (SPE) in analysis of these chemicals in environmental water samples. However, given the conflicts between the limited ion-exchange capacity of WAX cartridges and the relatively large enrichment coefficient required for analysis of these low pollution level chemicals, it is crucial to select appropriate water sample volumes for specific WAX cartridges in order to ensure the recoveries for all analytes. The objective of this study is to determine the breakthrough volumes of short- and long-chain PFCAs in analysis of sewage using specific WAX cartridges (60 mg, 3 cc) for SPE. The results indicate that the occurrence of breakthrough is dependent on not only the sample volume but also the perfluorocarbon chain length of analytes. The breakthrough volumes for short-chain PFCAs ( C10) in present study. The relatively low recoveries of long- chain PFCAs (>C10) are mainly due to matrix effects rather than breakthrough because internal standard is not suitable for these chemical. Finally, the volume selected for loading on WAX cartridges (60 mg, 3 cc) in analysis of sewage is 200 mL in order to avoid breakthrough for short-chain PFCAs ( C10). Meanwhile, this volume also ensures the quantitation of these chemicals presented in sewage samples because enrichment coefficients are large enough. | 2022-06-07T18:35:42.375Z |
17,824,519 | {
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"ArXiv": null,
"DOI": "10.15514/SYRCOSE-2012-6-19",
"MAG": "53141112",
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} | Nested Petri nets is an extension of Petri net formalism with net tokens for modelling multi-agent distributed systems with complex structure. Temporal logics, such as CTL, are used to state requirements of software systems behaviour. However, in the case of nested Petri nets models, CTL is not expressive enough for specification of system behaviour. In this paper we propose an extension of CTL with a new modality for specifying agents behavior. We define syntax and formal semantics for our logic, and give small examples of its usage. | 2022-07-31T01:21:26.710Z |
8,002,383 | {
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"ArXiv": null,
"DOI": "10.1145/2668904.2668939",
"MAG": "2095533569",
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} | We present a saliency-based parameter tuning algorithm that can optimize the parameters of tone mapping operators automatically by minimizing the saliency distortion caused by the process of tone mapping. The algorithm employs an improved saliency detection model for HDR images, and the saliency distortion is quantified as the Kullback-Leibler divergence between the saliency distributions of the tone mapped images and those of the corresponding HDR images. We show that the minimization can be accomplished by employing an evolution strategy with individuals representing parameter settings and fitness values based on saliency distortion. The effectiveness of our algorithm is demonstrated through experiments using several tone mapping operators and test images. | 2022-09-29T00:08:45.694Z |
90,206,299 | {
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"DOI": "10.1080/17550874.2018.1445128",
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} | ABSTRACT Background: Allometric scaling relationships are important in ecology and forestry. The metabolic scaling theory (MST) predicts a universal invariant scaling relationship for tree growth, relating height and diameter to each other. Aims: Data on five tree species (Pinus taeda L., Pinus virginiana Mill., Liquidambar styraciflua L., Liriodendron tulipifera L., and Pinus palustris Mill.) were used to test the predictions from MST on the scaling of height–diameter and also diameter growth. Methods: Data on tree height and diameter for five tree species from both natural forests and plantations were collected to study two types of scaling relationships: tree height–diameter and stem diameter growth. A reduced major axis of regression analysis model type II was used to determine scaling exponents from each species under different environmental conditions. Results: No universal invariant scaling exponent was found in height–diameter and diameter growth for the five species. The scaling varied across natural forests, plantations and scales (e.g., time and number of measured trees). However, in some situations the scaling exponents failed to show significant difference with the predicted values (e.g., 2/3 or 1). Conclusions: Diverse scaling exponents were observed for the five tree species with the scaling relationships varying with environmental settings. | 2022-12-04T20:01:00.312Z |
32,039,783 | {
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"DOI": "10.1001/ARCHOPHT.1994.01090240090031",
"MAG": "2510568395",
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"license": null,
"status": null,
"url": null
} | OBJECTIVE
To demonstrate a new diagnostic technique, optical coherence tomography, for high-resolution cross-sectional imaging of structures in the anterior segment of the human eye in vivo. Optical coherence tomography is a new, noninvasive, noncontact optical imaging modality that has spatial resolution superior to that of conventional clinical ultrasonography (< 20 microns) and high sensitivity (dynamic range, > 90 dB).
DESIGN
Survey of intraocular structure and dimension measurements.
SETTING
Laboratory.
PATIENTS
Convenience sample.
MAIN OUTCOME MEASURES
Correlation with range of accepted normal intraocular structure profiles and dimensions.
RESULTS
Direct in vivo measurements with micrometer-scale resolution were performed of corneal thickness and surface profile (including visualization of the corneal epithelium), anterior chamber depth and angle, and iris thickness and surface profile. Dense nuclear cataracts were successfully imaged through their full thickness in a cold cataract model in calf eyes in vitro.
CONCLUSIONS
Optical coherence tomography has potential as a diagnostic tool for applications in noncontact biometry, anterior chamber angle assessment, identification and monitoring of intraocular masses and tumors, and elucidation of abnormalities of the cornea, iris, and crystalline lens. | 2022-12-22T06:00:37.123Z |
238,411,546 | {
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"DOI": "10.1002/ccd.29960",
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"PubMedCentral": null
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} | To identify the vulnerable diabetic cohort in patients undergoing transcatheter aortic valve replacement (TAVR). | 2022-12-29T16:41:48.567Z |
4,676,225 | {
"externalids": {
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"ArXiv": null,
"DOI": "10.2147/CEG.S110547",
"MAG": "2591742226",
"PubMedCentral": "5344414"
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} | Ulcerative colitis (UC) is a chronic relapsing and remitting inflammatory bowel disease, with a characteristic leukocytic infiltration of the mucosa. Immunosuppression including anti-TNF-α therapy is a mainstay of treatment for many; however, systemic immunosuppression is not universally effective and is associated with potential side effects. The gut-tropic integrin α4β7, which is expressed on leukocytes, mediates migration from the circulation to the intestinal mucosa. Vedolizumab is a monoclonal antibody which blocks the egress of leukocytes via α4β7, preventing accumulation in the mucosa, and attenuating inflammation without systemic immunosuppression. Vedolizumab has been evaluated in UC in a phase III trial, demonstrating efficacy as both an induction and a maintenance agent. In this article, we review the clinical trial data and also explore the growing body of “real-world” effectiveness data, investigating response and remission rates of vedolizumab in clinical practice. In addition, we review the increasing volume of data supporting the reassuring safety profile associated with vedolizumab. | 2022-09-14T17:53:59.505Z |
234,300,424 | {
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"DOI": "10.5958/2249-7137.2021.00117.8",
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} | The article is devoted to the theoretical analysis of academic painting and the basics of graphic drawing in the practical studies of fine art as well as the methodology of teaching the role of drawing in painting. Technical skills are just as important to an artist as a child in 1st grade needs to know the letters when writing calligraphy. It should not be technically difficult during the practical exercise. Free and skillful acquisition of technical skills allows the student to be fully committed to creativity, to realize creative abilities and to become a highly qualified artist-educator. | 2022-11-01T07:13:25.781Z |
17,404,292 | {
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} | Uncharged reductants, such as NNN'N'-tetramethyl-p-phenylenediamine and diaminodurene, reduce cytochrome c at both high and low ionic strength, unlike ascorbate, which is effective only at low ionic strength. The 'tightly bound' cytochrome c-cytochrome c oxidase complex, with 1 equiv. of cytochrome c per cytochrome aa3, can be prepared by simple mixing of the two component species. Its properties are not affected by co-sonication of the mixture. Bound cytochrome c is more rapidly reduced by NNN'N'-tetramethyl-p-phenylenediamine and diaminodurene than is free cytochrome c. At high ionic strength, when the complex is largely dissociated, addition of reductant under aerobic conditions in the presence of cyanide, or under anaerobic conditions, induces a rapid reduction of cytochrome c followed by the reduction of cytochrome a. At low ionic strength, addition of reductant induces a rapid reduction of cytochrome a while cytochrome c remains largely oxidized, the rate-limiting step now being the reduction of cytochrome c. The results are interpreted in terms of direct reduction of cytochrome c in its tight complex with the oxidase, followed by rapid intramolecular electron transfer to both cytochrome a and the associated e.p.r.-detectable Cu atom. | 2022-12-15T12:49:31.032Z |
104,017,281 | {
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} | In an effort to dramatically increase the capacity and electronic conductivity of organic-based redox active materials for elec- trochemical/electrical energy storage applications, polypyrrole (PPy) has been used as an anchoring backbone to form a family of dimethoxybenzene-(DMB-),bis(methylthio)benzene-(BMTB-), N,N,N’,N’ -tetramethylphenylenediamine-(TMPD-),and N,N,N’, N’ -tetramethylbenzidine- (TMB-) functionalized redox-active polymers. PPy was deliberately modified to provide an electronically conducting backbone with redox active pendants (RAPs) to enable immobilization (via electropolymerization) of the polymers onto current collectors. The RAPs dramatically increase the capacities of the materials by the reversible exchange of multiple electrons per formula unit. The electropolymerization of the pyrrole-anchored RAP monomers was achieved via cyclic voltammetry. The stability of the electropolymerized films was highly dependent upon the redox potential of the RAPs. The effects of charge density, during the electropolymerization process, were studied by varying the structure of the monomers. By the systematic characterization of the electrochemical properties of the electropolymerized films, the electrochemical behavior of these polymers provides validation of our targeted design to maximize the energy density of organic electrode materials for electrical energy storage applications. © The Author(s) 2017. Published by ECS. This is an access distributed the terms the Creative Commons Attribution | 2022-09-09T07:24:27.250Z |
1,742,167 | {
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} | The following general conclusions were reached at the workshop: 1. Laboratory studies suggest a potential benefit of cellular transplant therapy for SCI. 2. Some evidence supporting the safety of human fetal transplants is available from clinical studies of transplants in Parkinson's disease and SCI. 3. Assessment criteria and methodology are available, including imaging approaches, validated neurologic scoring systems, detailed electrophysiologic studies of conduction and spinal cord reflexes, and functional scoring approaches. 4. More controlled animal studies are needed (a) to demonstrate efficacy and to evaluate the necessity for immunosuppressive therapy and the overall safety of intraspinal transplantation, (b) to obtain more supporting evidence (e.g., electrophysiologic, histopathologic, MRI, molecular) that would provide insights into ways that transplanted tissue could mediate function, (c) to provide guidance for the procurement, harvesting, preparation, storage, and other logistics related to the use of human cells for transplantation into the spinal cord, (d) to define more thoroughly the cell type(s) that would be most likely to have benefit and the conditions that affect their viability, migration, gene expressions, and proliferation after transplantation, (e) to determine the most optimal time after injury for transplantation, and (f) to clarify patient selection characteristics that might optimize success (i.e., complete vs incomplete injuries, spinal level involved, age of recipient). | 2022-09-08T22:05:33.856Z |
145,700,804 | {
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"DOI": "10.2139/SSRN.1013261",
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} | Services of general economic interest (SGEI) are a legal category in the EC Treaty that is designed to enable proportionate restrictions on the Treaty's market freedoms (including competition) in so far as necessary to attain legitimate public policy objectives defined (in the first instance) at national level. In principle this concerns those cases where market failures cannot be effectively remedied with market-based solutions. This paper aims to set out the history of the SGEI concept and its legal basis in order to examine the question whether it might provide a useful regime for those hospital services that cannot at present be subjected to full market-based provision - while solidarity based state provision is not an option, or is no longer desirable. The answer to this question is that there is indeed scope for applying SGEI. Especially since the Altmark Trans judgment of the European Court of Justice national governments may be expected to become increasingly proactive in designating SGEI in order to obtain state aid immunity. Universal service obligations (USO) that guarantee universal access are one of the most important examples of the way SGEI are operationalised, for which this paper proposes a structured test. Finally, as regards the proportionality test applied to SGEI this paper suggests that in the absence of Community level standards for SGEI this means testing whether intervention is manifestly disproportionate, whereas in cases where pre-emption by Community legislation has taken place, the least restrictive means test applies. | 2022-11-18T00:33:56.979Z |
28,593,700 | {
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} | The doubt-ended multigap ceramic thyratron is a versatile switch for crowbar applications. It will provide protection over a very wide range of HT voltages and will operate within a submicrosecond time delay. Since the tube operates in a normal nondestructive "thyratron mode" it will fire reliably for many millions of shots. Practical crowbar conditions can be complex, in particular with floating-deck modulators where stray capacitance and inductance can cause the HT voltage to ring and sometimes completely reverse. In the event of voltage reversal, the double-ended thyratron conducts smoothly in the reverse direction as the circuit requires. The paper describes a new range of compact double-ended thyratrons specifically designed for crowbar use up to 100 kV with an auxiliary power consumption of only 75 W. A dynamic test arrangement is described which demonstrates the tube's capability of discharging 0.75µF charged to 60 kV, the current rising to 5000 A at a rate of 50 kA/µs, with an anode delay time of 200 ns. The test equipment simulates either grounded cathode or floating-deck operation under conditions where a flash arc fault occurs. The efficiency of the protection is evaluated by monitoring the "let-through current" (i), charge (it), and energy (i_{2}t). Coincidence counters register faulty operations. A compact auxiliary supply module makes these tubes especially attractive to aerospace systems engineers. | 2022-12-12T15:36:59.876Z |
32,747,937 | {
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"url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jvec.12114"
} | ABSTRACT:
The objective of the present study was to identify mosquito fauna and to evaluate whether different light bulb colors influence the attraction of light traps in the Guapiaçu Ecological Reserve. Samples were obtained monthly during the period of February, 2012 to January, 2013. Centers for Disease Control (CDC) light traps with incandescent light bulbs and LED (ultraviolet, blue, green, and red) bulbs were utilized. In total, 8,170 specimens were captured, including 59 species. The presence of Anopheles nimbus (Theobald 1902) and Orthopodomyia fascipes Coquillet 1906 were recorded for the first time in the state of Rio de Janeiro. The green LED trap attracted the highest number of specimens and presented the highest diversity and mosquito average. The blue and green LED traps attracted the highest number of species. However, the differences between lights were not significant. The most common species were Coquillettidia juxtamansonia (Chagas 1907), Culex declarator Dyar and Knab 1906, and Culex ribeirensis Forattini and Sallum 1985. | 2022-12-25T22:48:44.168Z |
124,299,269 | {
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} | On 4 June last year the first attempt to make three-dimensional measurements in space was lost when the Ariane 5 rocket veered off course and self-destructed, 39 s into its maiden flight. On board were four identical spacecraft which made up Cluster,a mission that the European Space
Agency called a “cornerstone” of its Horizon 2000 scientific programme. A full description of the Cluster satellites is given in a special issue of Space Science
Reviews (Escoubet et al. 1997). Their loss dealt a devastating blow to the Cluster scientists and to those working on other missions and projects planned to
interact with Cluster. Many discoveries have been made during the 15 years in which Cluster progressed from an idea to the state-of-the-art satellites that were on
top of Ariane 501 on 4 June. However, these discoveries invariably underline rather than undermine the importance of
Cluster. Now plans to recover the unique and exciting research that was to be done using Cluster are well advanced. | 2022-12-23T01:59:55.013Z |
98,782,548 | {
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} | Hyper Raman scattering in crystals with an inversion centre is investigated using polariton theory. I n the Hamiltonian of a crystal, terms are taken into account, which are responsible for the intermolecular, kinematic interactions and the interaction of charges with the transverse photon field. The explicit form of the hyper Raman scattering tensor is calculated. For groups with an inversion centre the way of identification of the contribution of the intermolecular interaction to this effect is shown.
[Russian Text Ignored]. | 2022-12-30T20:22:21.696Z |
165,751,902 | {
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} | O presente texto estuda a novela Once Upon a Time, série americana de drama–fantasia que aborda o gênero contos de fadas, exibida pela ABC desde 2011. A série apresenta elementos e personagens de contos de fadas ocidentais populares e outras estórias literárias, combinados com a realidade contemporânea dentro de uma nova narrativa O trabalho tem por objetivo descrever os esquemas e modelos narrativos utilizados no seriado.Palavras-chave: Teoria narrativa. Narrativas seriadas. seriados de TV. | 2022-02-08T19:47:59.373Z |
204,394,904 | {
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"url": "https://nsuworks.nova.edu/cgi/viewcontent.cgi?article=3277&context=tqr"
} | As proficient speakers of less-commonly-taught languages seek to meet the demand for qualified instructors, they face a range of personal and professional challenges. In an effort to understand the perspectives of these instructors and their particular educational experiences and needs, we conducted a phenomenological case study of two aspiring Arabic teachers. Specifically, we sought insights into their lived experiences, their motivations for pursuing a graduate degree, their attempts to connect coursework with pedagogical practices, and their needs in terms of professional development. Our findings illuminate the intersecting objectives these instructors must achieve. They need to position themselves as qualified candidates for the available positions as instructors, but they also need to reconcile a number of different roles as they develop their teacher identities and connect their backgrounds to ambitions for students’ growth. As teacher educators, we find that we need to facilitate career placement as well as the negotiation of these roles. | 2022-04-08T00:30:46.479Z |
88,310,307 | {
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"DOI": "10.4172/2167-0897.1000145",
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} | This 15 days old male infant born at 38 weeks of gestation by spontaneous vaginal delivery was brought to paediatric emergency room with the history of hurried breathing and poor feeding and swelling in the neck (Figure 1). Clinical diagnosis of cystic hygroma with air way compromise was made. Antenatal scans done were normal. In view of deteriorating respiratory distress the child was ventilated. X-ray of neck showed mass on either side of the neck (Figure 2). Ultrasound demonstrated bilateral cystic areas consistent with cystic hygroma (multicystic) (Figure 3). CT neck wasdone to rule out any thoracic extension (Figure 4). The mass was infiltrated with sclerosant OK 432 (FDA approved) under ultrasound. | 2022-05-27T01:04:54.600Z |
250,752,709 | {
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"DOI": "10.1088/0031-9120/35/1/703",
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} | This is a quite remarkable book. If you want a quick and sketchy evening's read about your favourite popular scientist then this is not for you! On the other hand, if you want a detailed, fascinating and exhaustively researched story about a very special person, then read it. The author has produced a painstaking picture of Sagan. The main text consists of 430 pages of stories, anecdotes, quotations etc, which lead us through the complex life of a very complex man. This is backed up with a further 70 pages of detailed references followed by a 19 page bibliography. We learn about Sagan from his early days, when he was a somewhat precocious schoolboy, right up to his final days when he was in poor health yet still turning out books at a great rate. Like many people, I knew of him but not very much about him before I read this book. He was a man of giant energy who attempted to combine the life of a working research scientist with that of a great popularizer as well as extending his tentacles into various aspects of (scientific) government policy. Even in his early days his one aim in life seemed to be that of furthering his own career by getting to know as many well-known scientists as possible. He had fingers in many pies - academic, something mysterious and military related, book writing, popular science on TV etc, etc. He was particularly concerned with the space programme, especially the planetary probes and the Voyager vehicles which took messages from Earth to outer space. We get the impression from the book that he was especially obsessed with extraterrestrial life and was desperate to confirm its existence. He was instrumental in keeping the SETI programme going even though it eventually had to go private. We learn that he was not a good family man and work usually took precedence over domestic issues. As a result his private life seems to have been as complicated as his professional life. He was a man whose mind went in several directions at once and he was criticized at times for not following through his ideas. Perhaps he saw himself as the ideas man and preferred to leave the details to somebody else. Sometimes his ideas were wildly wrong, which is, perhaps, not surprising when working at the frontiers of science. One thing that surprised me was a suggestion by the author that his book The Dragons of Eden was `obviously written under the inspiration of marijuana'! It is easy and very tempting to criticize someone like Sagan after reading this book, which catalogues his many faults along with his many strengths. However, very few of us could attempt to accomplish even a tenth of what he accomplished in his lifetime. He had a health problem all through his life but nonetheless overcame all his personal and interpersonal problems to become the man that we all know, someone who made science, and especially astronomy, live for vast numbers of ordinary people. He aroused critical passions in many but, as Keay says, `In my years of research, I met not one person - not one - who knew Sagan closely and who strongly disliked him'. The book is an excellent read and gives a fascinating picture not only of the man but of science politics in the USA at the time. | 2022-07-23T12:25:00.946Z |
96,082,495 | {
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} | The degree of copper contamination in Ge heat-treated above 700 °C is studied by measuring the density of the copper levels in order to provide an experimental standard which serves to treat Ge at high temperatures. The degree of contamination is in the range 1013 to 1016 cm−3, depending upon the heat-treatment methods and the purity of water used to rinse specimens before the heat treatments. Joule heating in a vacuum attains the lowest degree of contamination, 2 × 1013 cm−3, above 900 °C. The results warn us to take into account the presence of an appreciable number of Cu atoms whenever thermally induced defects, impurity diffusion or precipitation, and dislocations are studied.
Kupferverunreinigung in oberhalb von 700 °C warmebehandeltem Ge wird durch Messung der Dichte der Kupferniveaus untersucht, um einen experimentellen Standard fur die Behandlung von Ge bei hohen Temperaturen zu erhalten. Die Verunreinigungskonzentration, die von der Warmebehandlung und von der Reinheit des zur Probenwaschung gebrauchten Wassers abhangt, liegt im Bereich von 1013 bis 1016 cm−3. Stromheizung der Probe im Vakuum ergibt die geringste Verunreinigung von 2 × 1013 cm−3 oberhalb von 900 °C. Die Ergebnisse zeigen, das man bei der Untersuchung von durch Abschrecken gebildeten Fehlstellen, Diffusion oder Ausscheidung von Verunreinigungen und von Versetzungen auch immer eine Verunreinigung durch Kupfer zu berucksichtigen hat. | 2022-12-19T04:35:47.407Z |
14,849,589 | {
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"DOI": "10.2139/ssrn.2330767",
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"status": "GREEN",
"url": "https://www.econstor.eu/bitstream/10419/212254/1/bof-rdp2013-014.pdf"
} | This study investigates whether the capital market values the efficiency of firms. After tracing stock returns and efficiency changes of 399 listed insurance firms in 52 countries during the 2002–2008 period, the paper reports a positive and statistically significant relationship between profit efficiency change and market adjusted stock returns. However, there is no robust evidence that cost efficiency change is associated with stock returns. | 2022-12-30T01:03:29.772Z |
225,074,736 | {
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} | Low yield was reported for a non-volatile embedded memory array. This memory array is constructed of cells with two transistors per cell. The cell is comprised of a non-volatile transistor in series with a special n-channel (select) transistor. This select transistor is comprised of n+ with an LDD (LightlyDoped Drain) spacer on the source side and a DDD (Doubly Diffused Drain) n+ junction on the drain side. In one case, this n-channel transistor was observed to exhibit single bit OFF leakage in a 32K array. In another case, there was general leakage (many cells in the array) observed between drain junctions of neighboring transistors, even though these were isolated by field oxide. The objective of the failure analysis described in this paper was to characterize the electrical behavior of the leakage and determine the exact location and cause of the leakage. | 2022-01-27T11:02:09.085Z |
137,431,672 | {
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"DOI": "10.4028/www.scientific.net/AMR.705.85",
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} | In this study, the effects of interfacial crack on thermal mechanical behavior of solder bump only induced by current for flip-chip package are investigated by numerical analysis. In the numerical model, the properties of solder bump are dependent on temperature. First, the crack length effects on thermal mechanical behavior of solder bump is examined, with the parameters of temperature, von Mises stress, shear stress and plastic strain. Second, the influence of current density is also numerically examined. It is demonstrated that the increasing current density and the crack length will induce more plastic strain in the solder bump. This study may be helpful for the fabricated technique of the die-solder bump-substrate system. | 2022-02-09T10:38:06.548Z |
58,987,850 | {
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} | Bei 40 Patienten wurde im Rahmen der Belastungs-Aquilibrium-Radio-nuklid-Ventrikulographie die bela-stungsinduzierte Anderung der spezifischen Blutradioaktivitat untersucht. Wir fanden nach maximaler Belastung eine signifikante (p <0.025) Zunahme der Radioaktivitatskonzentration um +7.2%. Dieser Anstieg fand seine Ursache in einem ebenfalls signifikanten (p <0.025) Anstieg des Hamatokrits (mittlere Zunahme +4.7%). Die Anderungen von Hamatokrit und spezifischer Blutaktivitat waren weder mit Belastungsdauer, mit maximaler und integraler Belastung noch mit der Zunahme von Herzfrequenz und Blutdruck statistisch korreliert. Es zeigt sich, das eine Zunahme des enddiastolischen Volumens nach koperlicher Belastung im wesentlichen auf eine angestiegene spezifische Blutaktivitat zuruckzufuhren war. Deshalb sollten, falls im Rahmen der Radionuklid-Ventrikulographie belastungsindu-zierte Volumenanderungen untersucht werden, Blutaktivitatsbestimmungen in Ruhe und unmittelbar nach korperlicher Belastung durchgefuhrt werden. | 2022-02-11T17:04:36.165Z |
226,916,592 | {
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"DOI": "10.1254/jpssuppl.wcp2018.0_sy49-3",
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"url": "https://www.jstage.jst.go.jp/article/jpssuppl/WCP2018/0/WCP2018_SY49-3/_pdf"
} | Long-chain fatty acids (LCFA) are important regulators of pancreatic islet function. Acutely, LCFA amplify glucose-induced insulin secretion from pancreatic beta cells. However, when present at excessive levels for prolonged periods of time, LCFAs impair beta-cell function. The discovery of G protein-coupled receptors (GPCRs) that are activated by LCFA in the early 2000s has prompted major drug discovery efforts to target these receptors for the treatment of metabolic diseases. Of these, FFA1 (GPR40) is predominantly expressed in pancreatic beta cells. While some controversy remains as to whether prolonged FFA1 activation would have undesirable side effects, most drug discovery programs have focused on the development of FFA1 agonists to enhance insulin secretion in type 2 diabetes. Studies from our group have provided evidence that FFA1 contributes to the maintenance of glucose homeostasis under normal conditions and in response to insulin resistance in rodents. However, clinical development of an FFA1 agonist was abruptly halted due to liver toxicity. FFA4 (GPR120) is structurally divergent but shares the same endogenous ligands with FFA1. The expression pattern of FFA4 is more ubiquitous, and its activation of this receptor in adipocytes and macrophages has been proposed to mediate the anti-inflammatory and insulin-sensitizing effects of omega-3 fatty acids, although this remains controversial. In islets, FFA4 is preferentially expressed in somatostatin-secreting delta cells and its activation inhibits somatostatin secretion, which indirectly stimulates insulin secretion. Therefore, FFA1 and FFA4 appear to play complementary roles in pancreatic islet function. However, many aspects of the biology and pharmacology of these receptors remain to be clarified. | 2022-06-06T09:15:52.299Z |
85,140,182 | {
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} | Este trabalho objetivou estimar a natureza e a magnitude dos efeitos da capacidade combinatoria geral (CGC) de seis genitores e especifica (CEC) de nove hibridos, provenientes de um esquema de cruzamentos dialelicos parciais. O experimento foi realizado na Estacao Experimental da Embrapa Rondonia, em Machadinho do Oeste – RO, no periodo de marco a junho de 2005. Os tratamentos compuseram-se de dois grupos de genitores, sendo o primeiro composto pelas linhagens Cpafro 34.305, Cpafro 74.105 e Cpafro 45.202; e o segundo, pelas cultivares comerciais ‘Charleston Gray’, ‘Sugar Baby’ e ‘Omaru Yamato’, alem dos nove hibridos, os quais foram avaliados em delineamento em blocos casualizados, com tres repeticoes, e parcelas de sete plantas, quanto a 10 caracteristicas agronomicas. Os efeitos da CGC foram superiores aos da CEC para a maioria das caracteristicas estudadas, evidenciando a predominância do efeito aditivo no controle genico destas. Na maioria dos genitores, foram verificados efeitos de CGC favoraveis ao melhoramento da cultura, sendo ‘Sugar Baby’ e ‘Charleston Gray’ os genotipos mais promissores para estrategias de melhoramento intrapopulacional visando a obtencao de cultivares de frutos pequenos e grandes, respectivamente. Com base na CEC, as combinacoes hibridas superiores e, portanto, com maior potencial de aproveitamento comercial foram: Cpafro 74.105 x Sugar Baby, de frutos pequenos e Cpafro 74.105 x Charleston Gray, de frutos grandes. | 2022-09-11T11:43:25.606Z |
247,100,724 | {
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} | The objective of this article is to design, develop, and evaluate an Internet of Things (IoT)-based serious gaming platform for children with autism spectrum disorder The platform aims to improve the children’s cognitive skills. To attain this research objective, first, a conceptual framework for developing the gaming platform was proposed. Then, the conceptual ideas were materialized by developing three games (a puzzle game, a function card game, and a road crossing game) to be included in the gaming platform, which also incorporated a mobile application and three hardware systems. The hardware platform was used to play the game, and the mobile application was used to select, control, manage, and store the gaming performance and visualize players’ progress. The proposed gaming platform was evaluated with 15 special needs children. We found that the gaming platform was usable, effective, and useful for the children on the spectrum and noticeably contributed to improving their cognitive skills. | 2022-12-10T01:28:08.417Z |
229,930,262 | {
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"url": "https://www.jidc.org/index.php/journal/article/download/33378295/2430"
} | INTRODUCTION
Enterococcus hirae (E. hirae) constitutes less than 1% of the enterococci strains in human clinical specimens. In this article, we report the first case of urinary tract infection-related bacteremia due to E. hirae from Turkey.
CASE PRESENTATION
A 74-year-old male patient with a history of coronary artery disease, hypertension, and chronic renal failure was admitted to the emergency department with abdominal pain, dysuria, and fever. The urine sample collected from the urinary catheter resulted as ampicillin-sensitive E. hirae. On the 4th day of hospitalization, E. hirae growth with the same sensitivity pattern was also reported in blood culture. Intravenous ampicillin 4×2 g/day treatment was initiated. There was no growth in subsequent blood and urine cultures. Fever resolved and general condition improved. The patient was discharged on the thirteenth day with clinical improvement after moxifloxacin treatment for four days and ampicillin treatment for nine days.
DISCUSSION
The patient's medical history included risk factors for enterococcal bacteremia. There are a limited number of reports in the literature describing human infections caused by E. hirae. The reason for the rare isolation of E. hirae from clinical specimens may be the difficulty of identifying with standard diagnostic approaches.
CONCLUSIONS
For diagnostic purposes, as in our case, rapid and high sensitive diagnostic methods such as Matrix-assisted Laser Desorption/Ionization Time of Flight (MALDI-TOF) and molecular techniques may be useful to guide the selection of the least toxic and optimal duration of antibiotic treatment. | 2022-12-12T10:35:37.530Z |
5,311,826 | {
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"license": null,
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"url": "http://arxiv.org/pdf/0904.4182"
} | We consider the asymmetric branes model of modified gravity, which can produce late time acceleration of the universe and compare the cosmology of this model to the standard ΛCDM model and to the DGP braneworld model. We show how the asymmetric cosmology at relevant physical scales can be regarded as a one-parameter extension of the DGP model, and investigate the effect of this additional parameter on the expansion history of the universe. | 2022-12-18T01:08:33.445Z |
225,559,925 | {
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"DOI": "10.1302/2633-1462.17.BJO-2020-0075.R1",
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} | Aims Now that we are in the deceleration phase of the COVID-19 pandemic, the focus has shifted to how to safely reinstate elective operating. Regional and speciality specific data is important to guide this decision-making process. This study aimed to review 30-day mortality for all patients undergoing orthopaedic surgery during the peak of the pandemic within our region. Methods This multicentre study reviewed data on all patients undergoing trauma and orthopaedic surgery in a region from 18 March 2020 to 27 April 2020. Information was collated from regional databases. Patients were COVID-19-positive if they had positive laboratory testing and/or imaging consistent with the infection. 30-day mortality was assessed for all patients. Secondly, 30-day mortality in fracture neck of femur patients was compared to the same time period in 2019. Results Overall, 496 operations were carried out in 484 patients. The overall 30-day mortality was 1.9%. Seven out of nine deceased patients underwent surgery for a fractured neck of femur. In all, 27 patients contracted COVID-19 in the peri-operative period; of these, four patients died within 30 days (14.8%). In addition, 21 of the 27 patients in this group had a fractured neck of femur, 22 were over the age of 70 years (81.5%). Patients with American Society of Anesthesiologists (ASA) grade > 3 and/or age > 75 years were at significantly higher risk of death if they contracted COVID-19 within the study period. Conclusion Overall 30-day postoperative mortality in trauma and orthopaedic surgery patients remains low at 1.9%. There was no 30-day mortality in patients ASA 1 or 2. Patients with significant comorbidities, increasing age, and ASA 3 or above remain at the highest risk. For patients with COVID-19 infection, postoperative 30-day mortality was 14.8%. The reintroduction of elective services should consider individual patient risk profile (including for ASA grade). Effective postoperative strategies should also be employed to try and reduce postoperative exposure to the virus. Cite this article: Bone Joint Open 2020;1-7:392–397. | 2022-12-24T06:08:02.188Z |
85,308,599 | {
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} | A time-course investigation was made of early events in leaves of four rice cultivars following inoculation with Pyricularia oryzae Cavara race 131. The pathogen conidia germinated and formed appressoria at a similar frequency in all four cultivars. A difference was found in fungal penetration frequency among the cultivars but it did not appear to be related to race-specific resistance. Growth inhibition of infection hyphae was pronounced in incompatible race–cultivar combinations relative to compatible ones, and a correlation between inhibition of infection hyphae and expression of race-specific resistance was found. The cultivars showed five types of cellular reactions to the pathogen. Light browning and aniline blue staining of the epidermal cell wall (type B reactions) were the first reactions observed in all cultivars and a decrease in their frequency was followed by an increase of other cellular reactions such as cytoplasmic granulation or cell necrosis. This result suggested that cytoplasmic granul... | 2022-12-27T16:59:19.753Z |
19,259,970 | {
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} | Revisiting material previously presented and successfully assessed can lead to much frustration among teaching staff and students. Despite this, it is often a requirement due to the time lag between the point at which a student begins a module and the time when they successfully passed a prerequisite module. Also, students who successfully pass a module fit into a number of categories, from those who were successful in all components of the assessment to those who displayed the minimum level of competence required for satisfaction of the learning outcomes. We introduce a novel instructional model which we predict will be instrumental in assisting our undergraduate Software Engineers who have displayed medium levels of competence in passing practical modules. The R-CUBE recognizes the importance of three dimensions to revisiting material - review, reinforce and reward. Our initial implementation of instruction using the model employs novel teaching and learning methods closely tied to our experience with service learning projects. We expect to fully evaluate the effectiveness of the model when the first students pass through a project that employs it at the end of this academic year. | 2022-02-12T23:11:20.613Z |
242,004,397 | {
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"url": "https://www.mdpi.com/2075-4701/11/10/1611/pdf?version=1634291305"
} | In this study, the mechanical properties and deformation features of Zr-based bulk metallic glass (BMG) are investigated at micro-scale via in situ micro-pillar compression. Furthermore, the effects of the strain rate and micro-pillar diameter on respective stress–strain curves are investigated. Together with the mechanical properties, such unique in situ micro-pillar compression techniques provide physical status to the micro-pillars, referring to the instances of stress–strain curves. It is noted that the effect of the strain rate on the stress–strain behaviour of the BMG diminishes with increasing micro-pillar diameter. In contrast, yield and ultimate compressive strength increase with increasing micro-pillar diameter, up to 4 µm. The deformation details after compression, as a result of conformed mechanical loading, are analysed by SEM and TEM. As evident from electron microscopy investigation, the plastic deformation is evidenced by the presence of multiple slip/shear bands, acting as load accommodation mechanisms in the course of mechanical loading together and resemble local plastic flow (ductile in nature) between two shear plans. | 2022-08-13T14:35:18.984Z |
3,383,543 | {
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"DOI": "10.1051/ro/2016073",
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} | Quickest time , which is the least possible time necessary to transmit a fixed amount of data from a source node to a destination node, has been widely explored in the past few years. A quickest path transmits data via a single path, whereas a quickest flow transmits data via all possible paths. In a dynamic stochastic-flow network in which each arc capacity is a discrete random variable having several possible integer values, the quickest time is not a fixed value. Existing literature computes the reliability that the specified amount of flow can be sent simultaneously from the source to the destination through multiple k disjoint minimal paths within a given time horizon. This article presents a decomposition algorithm to compute the probability distribution of the quickest time of a dynamic stochastic-flow network from the viewpoint of flow (all disjoint and non-disjoint minimal paths simultaneously) rather than of k disjoint minimal paths only. The distribution of quickest time is important for the design and analysis of evacuation systems, as they are generally analyzed and optimized via the quickest flow models. As a result, the expected quickest time and the probability that the quickest time is no larger than a specified time threshold can be determined directly. The proposed algorithm can be easily modified to approximate the probability distribution by trading off accuracy for execution time when the network system is large. Computational experiments are conducted to illustrate the proposed algorithms. | 2022-12-05T19:55:51.585Z |
25,455,509 | {
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"DOI": "10.1515/znc-2010-9-1003",
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"url": "https://www.degruyter.com/document/doi/10.1515/znc-2010-9-1003/pdf"
} | Hydroxydihydrocarvone (HC) is a synthetic intermediate obtained by hydration of the natural compound (R)-(-)-carvone. The aim of the present study was to investigate the possible anti-inflammatory activity of orally administered HC. Toxicity, motor coordination, tail immersion test, as well as carrageenan-induced paw edema and myeloperoxidase (MPO) activity or peritonitis were all evaluated in rodents. HC was force-fed to the animals 1 h before the stimulus. The lethal dose 50% (LD50) of orally administered HC was 1259 mg/kg. No changes in motor coordination were recorded in HC-treated mice in the rotarod test. The time of response to the thermoceptive stimulus in the tail immersion test was longer in HC-treated animals (50, 100, and 200 mg/kg) than in the vehicle-treated group. HC also significantly decreased the area under curve of carrageenan-induced rat paw edema at 100 and 200 mg/kg and MPO activity at 200 mg/kg. Carrageenan-induced neutrophil recruitment to the peritoneal cavity was significantly reduced by HC at doses of 100 or 200 mg/kg, but not 50 mg/kg. These findings demonstrate that orally administered HC exerts antinociceptive and anti-inflammatory activities in rats and mice. | 2022-12-12T16:37:12.162Z |
231,974,967 | {
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"DOI": "10.1109/ICPES51309.2020.9349638",
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} | This article is based on XC7Z020 chip, one of a series chips Zynq-7000 SoC made by Xilinx, to build a permanent magnet synchronous motor (PMSM) servo drive system. The principle of vector control and PID control are used to accomplish the closed-loop control model which includes current loop, speed loop and position loop. Then the three loops are realized in the servo drive system. The servo drive is composed of main control board, interface board, driver board and power board. The external design of the servo drive is an open interface, and for the internal, we use a stacked layered structure to reduce the volume and optimize the layout. The ARM implements control algorithms, communication protocols and auxiliary functions; while FPGA implements functions such as feedback processing, output of PWM wave and hardware protection. Finally, the servo drive system is placed under working conditions, and tests of no-load and different loads are carried out with various temperatures. Experimental results show that the driver is stable and reliable, meets engineering requirements, and can achieve precise control of torque, speed, and position. | 2022-12-14T09:18:31.786Z |
20,965,052 | {
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"DOI": "10.1093/bioinformatics/btw376",
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"url": "https://academic.oup.com/bioinformatics/article-pdf/32/21/3314/7889600/btw376.pdf"
} | MOTIVATION
Spatial learning is one of the most widely studied cognitive domains in neuroscience. The Morris water maze and the Barnes maze are the most commonly used techniques to assess spatial learning and memory in rodents. Despite the fact that these tasks are well-validated paradigms for testing spatial learning abilities, manual categorization of performance into behavioral strategies is subject to individual interpretation, and thus to bias. We have previously described an unbiased machine-learning algorithm to classify spatial strategies in the Morris water maze.
RESULTS
Here, we offer a support vector machine-based, automated, Barnes-maze unbiased strategy (BUNS) classification algorithm, as well as a cognitive score scale that can be used for memory acquisition, reversal training and probe trials. The BUNS algorithm can greatly benefit Barnes maze users as it provides a standardized method of strategy classification and cognitive scoring scale, which cannot be derived from typical Barnes maze data analysis.
AVAILABILITY AND IMPLEMENTATION
Freely available on the web at http://okunlab.wix.com/okunlab as a MATLAB application.
CONTACT
[email protected] information: Supplementary data are available at Bioinformatics online. | 2022-12-29T18:35:30.882Z |
210,455,116 | {
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"DOI": "10.1093/oso/9780190053710.003.0004",
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} | Some cities are more compact, and others are more sprawled; some are more segregated by class or race, and others are more socially cohesive. The outcomes are always in part shaped by national policies. This chapter first explores the drivers of urban form and of social and economic relations in cities, beginning with public policies toward transit, car use, and the consumption of land. Then it turns to the role of downtowns in shaping cities. The greatest challenge remains the promotion of social cohesion and social peace in large, diverse urban regions, notably in ethnically and racially divided societies. Instituting appropriate models of metropolitan governance, ensuring the equitable provision of people services (such as education and health), and curbing exclusionary practices (NIMBYs) are core issues, which societies have approached differently. The success of Vienna, ranked the world’s most livable city, has its roots in a unique model of metropolitan governance and housing provision but one that is difficult to transpose to other national settings. | 2022-02-08T03:28:22.140Z |
248,637,385 | {
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"DOI": "10.21608/mjcu.2022.234980",
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"url": "https://mjcu.journals.ekb.eg/article_234980_ed07c02e430649f79d1d16f7da41d400.pdf"
} | Background: Skin tumors represent 4.78% of primary malignant tumors in Egyptian patients. Among the common skin tumors in Egyptian patients; are invasive keratinocytic/ epidermal tumors, constitutes 78.5% of primary skin tumors. Cancer stem cells (CSCs) are a population of cells responsible for tumor initiation, cancer progression and therapeutic resist- ance in manycancers. The CD133 protein is a transmembrane glycoproteinthat has been considered a putative and important CSC biomarker in various tumors, including gastric, breast, and colon tumors. Nestin is an intermediate filament protein that was described as a marker of neural progenitor cells during development of the central nervous system. In tumors, nestin expression is reported in malignancies of various tissues, and high levels have been correlated with aggressive features in brain tumors, non-small cell lung cancer and breast cancer. Aim of Study: To study the immunohistochemical expression of stem cell markers; CD133 and nestin in some skin tumors, to evaluate the relation of their expression with other histopathologic features and other predictor parameters in these tumors. Methods: expression in normal structures. Results: All cases of normal skin included showed negative immunostaining for nestin and CD133. Except for a limited nestin expression related to hair follicles. Nestin was expressed in 14 out of the 20 cases of squamous cell carcinoma (70.0%) with a statistically significant direct relationship between nestin expression and tumor size (P-value 0.015), and tumor grade ( p -value 0.04). Nestin was not expressed in any of the 20 cases of basal cell carcinoma or 4 cases of trichoblastoma examined. CD133 was not expressed in any of squamous cell carcinoma, basal cell carcinoma or trichoblastoma cases examined. Conclusion: Cancer stem cell markers; nestin and CD133 are not expressed in normal skin with exception of limited nestin expression related to hair follicles, a findings that suggest a role of both markers related more to neoplastic process rather than normal physiological processes. Nestin was expressed in squamous cell carcinoma with statistically significant relationship with tumor size (measured by maximal tumor dimension) and tumor grade. This may explain in part the aggressive behaviour of some high-grade squamous cell carcinoma cases. Nestin was not expressed in basal cell carcinoma; which may indicate different cellular origin and may explain the indulant locally malignant behaviour of such tumors. | 2022-05-14T00:44:12.290Z |
27,724,976 | {
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"DOI": "10.17311/SCIINTL.2015.85.89",
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} | Background: Although, the literature is abundant on the adverse effects of micronutrient deficiencies on neurocognitive performance, iron deficiency is a major public health problem worldwide because it continues to be the single most common nutritional deficiency and the main cause of anaemia in infancy and childhood. Nutritional anemia occurs when body reserves for a specific nutrient are inadequate for the synthesis of hemoglobin. This deficiency is due to inadequate iron intake and poor bioavailability. According to the World Health Organization (WHO), more than 2 billion people in the world today are estimated to be deficient in iron deficiency. Objectives: Rates of the highest prevalences in the developing world were found among pregnant women with 56% of school children followed directly 53%. The distribution of iron in the brain is very heterogeneous, a characteristic of the species in which the concentrations were determined. The highest concentrations are localised in the nucleus accumbens, the substantia nigra (nigra), the nucleolus cerebellar deep red nucleus and some portions of the hippocampus. These distributions occur at an advanced age especially when all the neuro-developmental activity is performed. Results: Iron supplementation improves mental development scores of anemic children. These results are amplified by psychosocial stimulation at home or in specialized centers. In sectoriel studies that our team has made in the region of Kenitra with populations of school children, the results are unanimous on the correlation between martial status and school performance and/or overall intelligence score determined by Raven’s Progressive Matrices when socioeconomic variables are controlled. Conclusion: A comprehensive study using evoked potentials is desirable to confirm the relationship between iron deficiency neuro-cognitive development. | 2022-08-25T19:30:09.151Z |
33,925,109 | {
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"DOI": "10.1080/14999013.2017.1405126",
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} | ABSTRACT Research has shown that psychopathic individuals ignore information that is outside their goal-directed focus of attention. When affective information is goal-irrelevant, ignoring it results in a blunted affective response for psychopathic individuals. In cognitive science, though, an interesting phenomenon named inhibitory devaluation occurs in the context of neutral information. When neutral information is not relevant to a goal, ignoring it actually results in individuals' evaluating the neutral information as negatively valenced. In a sample of adult male offenders (N = 82), we used a pattern localizer task to examine the relationship between inhibitory devaluation and psychopathy (using scores on the Psychopathy Checklist-Revised). Results indicated that individuals high on the interpersonal-affective traits of psychopathy displayed significantly greater inhibitory devaluation, meaning that they ascribed more affective valence to goal-irrelevant neutral information. This finding provides further support for the importance of attention abnormalities in the neurobiology of psychopathy-related affective and interpersonal deficits. | 2022-09-04T12:05:29.873Z |
127,657,943 | {
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"DOI": "10.5309/WILLMARYQUAR.72.3.0423",
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} | British Nova Scotia in the early eighteenth century had overlapping geographic identities. French officials and settlers called the region Acadia, while Native polities inhabited their homelands as they had for thousands of years. The Mi’kmaq lived in Mi’kma’ki, the Wulstukwiuk and Passamaquoddy were sustained by the Wulstuk River, and the Abenaki Dawnland stretched across what is now Maine. During a period of relative peace from 1726 to 1744, these Native and non-Native groups monitored settlements, movements, and borders to prevent any unacceptable displays of territorial authority. In so doing, they created shared spaces of interaction: economic (fishing and trading), diplomatic (negotiating and gift-giving), and religious (worshipping and communing). Sovereignty remained elusive and European settlements were pales, but exchanges took place at various seasonal or temporary sites that allowed various groups to maintain peace, air grievances, and balance territorial control. These sites were created, supported, and allowed to dissolve as necessary. British officials did not always employ these sites effectively, whereas the French benefited from a longer history of interaction with the Native groups, who remained the dominant force in the region. Imperial claims to sovereignty were tempered locally by officials who recognized that their limited authority was a boon to peace. | 2022-09-15T01:13:04.403Z |
120,826,555 | {
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"DOI": "10.1063/1.356440",
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} | Epitaxial growth in the TiN/Si and TiN/GaAs metal‐semiconductor systems with a large lattice mismatch was investigated. The orientation relationships have been found to be 〈001〉TiN∥〈001〉Si for TiN growth on Si(001) and [001]TiN∥[110]GaAs and [110]TiN∥[110]GaAs for TiN growth on GaAs(001). The epitaxial growth is characterized by domain epitaxial orientation relationships with m lattice constants of epilayer matching with n of the substrate and with a small residual domain mismatch present in the epilayer. This residual mismatch is responsible for a coherent strain energy. The magnitude of compression of Ti—N bond in the first atomic layer, contributing to the chemical free energy during the initial stages of growth, is found to be a very important factor in determining the orientation relationship. This result was used to explain the differences in the orientation relationships between TiN/Si and TiN/GaAs systems. The various energy terms associated with the domain epitaxial growth are evaluated to illu... | 2022-11-24T17:22:47.874Z |
205,864,505 | {
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} | Dibutyltin (DBT), a widely used plastic stabilizer, has been detected in the environment as well as human tissues. Although teratological and developmental effects are well documented, there are no published reports of DBT effects on the developing nervous system. As part of a developmental neurotoxicity study of DBT, tissue samples were periodically collected to determine the distribution of total tin (Sn) in brain and whole blood. Pregnant Sprague-Dawley rats were exposed to 0, 10, or 25 ppm DBT in drinking water from gestational day (GD) 6 to weaning at postnatal day (PND) 21. Beginning on PND 3, half of the litters were directly dosed every 2 to 3 d via oral gavage with 0, 1, or 2.5 mg/kg DBT such that the dose level matched the water concentration (for example, litters with 25 ppm DBT in the water received 2.5 mg/kg). For Sn analysis, brain and blood samples were collected from culled pups on PND2 (males and females pooled), from pups (males and females separately) as well as dams at weaning (PND21), and from adult offspring (males and females) at PND93. Total Sn was quantified using inductively coupled plasma–mass spectroscopy (ICP-MS). At all ages, brain Sn levels were higher than blood. At culling, in the directly dosed pups at weaning, and in dams at weaning, Sn levels in both tissues were linearly related to dose. Weanling pups without direct dosing showed lower levels than either culled pups or dams, indicating that lactational exposure was minimal or negligible even while maternal exposure is ongoing. In the adults, Sn levels persisted in brains of directly dosed rats, and the high-dose females had higher levels than did high-dose males. No Sn was detected in adult blood. Thus, during maternal exposure to DBT in drinking water, Sn is placentally transferred to the offspring, but lactational transfer is minimal, if any. Furthermore, Sn is concentrated in brain compared to blood, and its elimination is protracted, on the order of days to months after exposure ends. | 2022-12-18T05:03:04.356Z |
213,436,408 | {
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} | Short-circuit current calculation and its characteristic analysis are the foundation of selecting circuit breakers and designing protection systems. First, a companion circuit-based method is presented to fast calculate the short-circuit current of asymmetric bipolar modular multilevel converter-based multiterminal direct current (MMC-MTDC) grids. With the reduction of the whole MTDC grid into an equivalent RLC circuit, the short-circuit current of the grid is efficiently and accurately solved by companion circuit method instead of the numerical integration. In addition to the efficiency, the proposed method can readily adapt to various types of MTDC grids and all kinds of dc faults. Second, unique short-circuit current characteristics of a bipolar MTDC grid following different types of dc faults are theoretically analyzed. A fault type discrimination method is then proposed for bipolar MMC-MTDC grids with dedicated metallic return. Finally, intensive numerical results of two MTDC grids validate the accuracy, adaptability, and efficiency of the presented dc grid short-circuit current calculation method as well as the correctness of the short-circuit current characteristic analyses. | 2022-12-21T16:48:32.906Z |
234,427,034 | {
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"url": "https://academic.oup.com/ofid/article-pdf/7/Supplement_1/S197/35343932/ofaa439.444.pdf"
} |
Effective career mentorship enhances well-being, productivity, and advancement in academic medicine. The pathway to success for clinician educators (CE) is often ill-defined. Career development resources and support for this pathway vary across institutions. To address this need, we created a mentoring program pairing junior faculty pursuing careers as CEs with more experienced CEs from other institutions during IDWeek 2018 and 2019.
Prior to IDWeek 2018 and 2019, a survey was sent through the IDSA listserv to identify members pursuing CE careers interested in extra-institutional career mentorship. These faculty were paired with mentors who were established career CEs identified via the IDSA Medical Education Workgroup. Mentees completed a brief individual development plan (IDP) and identified 3 discussion topics. Mentors received the mentee’s IDP and CV prior to IDWeek and were given brief guidance on successful mentoring. One hour advising sessions were held during IDWeek and ended with the creation of a mentee action plan and a scheduled follow-up call. Post-participation surveys were sent to mentees and mentors.
31 different mentees and 15 mentors participated in the program over two years. 26 (84%) mentees completed the post-session survey. 25 (96%) mentees and 14 (93%) mentors reported being very satisfied with their meetings at IDWeek. All mentees created an action plan with their mentor. 16 (62%) strongly agreed and 10 (38%) somewhat agreed that they planned to make changes based on the meeting. 21 (81%) mentees strongly agreed they received advice they were unable to get at their own institution. After the session, 18 (69%) strongly agreed they felt connected to a supportive CE community at IDSA; none strongly agreed in the pre-survey. All mentors and mentees agreed that this program was a resource that IDSA should consider expanding. Qualitative response themes from mentees emphasized the usefulness of an external perspective.
A mentoring program for junior faculty during IDWeek was feasible and effective for CEs. Through these interactions, mentees planned changes to enhance their careers and felt newly supported by the IDSA community. This model could be used for other ID career paths at future meetings.
All Authors: No reported disclosures
| 2022-01-27T06:27:07.384Z |
56,351,031 | {
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} | Mutual Information (MI) is an information theory concept often used in the recent time as a criterion for feature selection methods. This is due to its ability to capture both linear and non-linear dependency relationships between two variables. In theory, mutual information is formulated based on probability density functions (pdfs) or entropies of the two variables. In most machine learning applications, mutual information estimation is formulated for classification problems (that is data with labeled output). This study investigates the use of mutual information estimation as a feature selection criterion for regression tasks and introduces enhancement in selecting optimal feature subset based on previous works. Specifically, while focusing on regression tasks, it builds on the previous work in which a scientifically sound stopping criteria for feature selection greedy algorithms was proposed. Four real-world regression datasets were used in this study, three of the datasets are public obtained from UCI machine learning repository and the remaining one is a private well log dataset. Two Machine learning models namely multiple regression and artificial neural networks (ANN) were used to test the performance of IFSMIR. The results obtained has proved the effectiveness of the proposed method. | 2022-02-11T19:23:54.156Z |
75,933,296 | {
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} | The diagnosis of hepatolithiasis, a condition which had previously been difficult to diagnose and treat, has become easier because of ultrasonic examination and puncture under ultrasonographic imaging. The results of treatment have also improved with the development of lithotomy under percutaneous cholangiographic observation by ultrasound, i.e., the application of ultrasonic examination and puncture. However, cholangiocarcinoma occurring as a complication of hepatolithiasis remains an important problem. The clinical course of a 28-year-old male patient who suffered cholangiocarcinoma associated with hepatolithiasis for 12 years is reported with references to the Japanese literature. Since cases of cholangiocarcinoma associated with hepatolithiasis are considered to result from repetition of chronic intrahepatic cholangitis and bile stagnation, it is necessary for the treatment of hepatolithiasis to perform ultrasonic examination together with biopsy of the bile duct in the liver by selective arteriography, biliary cytodiagnosis or cholangioscopy, even after lithotomy, and to continue careful postoperative observation. | 2022-02-11T06:55:18.835Z |
36,669,968 | {
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"DOI": "10.1002/SAPM1947261104",
"MAG": "2321871904",
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} | Laplace transform, L(s)f)h, is meant a linear functional of ƒ with the fundamental property tfiatL(s;fc/)fc-sL(s;/)*^ f?<>t-°~nlf(t)dt, EJJ/(*)(l+s)-* < " are generalized L.T.'s for d/dt, E, td/dt, and A respectively. I t may be verified tha t the appropriate expression is in every case given formally by \imt^wF(t} s, 0;f)F(t, s} 1 ; 0)~ l . Tables of transform pairs may be set up for practical use precisely like those of the usual Laplace transform. Regions of convergence must be determined for each different operator; however, in practice it is often possible to get the correct answer by proper "interpretation" even when convergence fails. (Received January 15, 1947.) | 2022-02-12T07:28:20.497Z |
55,709,445 | {
"externalids": {
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"DOI": "10.1155/2016/1486189",
"MAG": "2292729767",
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},
"license": "CCBY",
"status": "GOLD",
"url": "http://downloads.hindawi.com/journals/mpe/2016/1486189.pdf"
} | Due to customers’ growing concern about logistics performances related to products, logistics service increasingly contributes to the core competence of an enterprise or product, which calls an appropriate tool to develop effective strategic actions to improve logistics performances and gain customer satisfaction. Therefore, an uncertain quality function deployment (QFD) approach for selecting the most effective strategic actions in terms of efficiency to meet the customer requirements is developed in this paper, which integrates uncertainty theory into the traditional QFD methodology in order to rationally deal with imprecise information inherently involved in the QFD process. The framework and systematic procedures of the approach are presented in the context of logistics services. Specifically, the calculations for the prioritization of strategic actions are discussed in detail, in which uncertain variables are used to capture the linguistic judgements given by customers and experts. Applications of the proposed approach are presented as well for illustration. | 2022-09-01T01:43:07.987Z |
53,244,142 | {
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"DOI": "10.1159/000494054",
"MAG": "2899638177",
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} | Introduction: Recently, we identified three novel fetal-specific epigenetic DNA regions (FSERs) on chromosome 21 for detection of noninvasive fetal trisomy 21 (T21). In this study, the diagnostic accuracies of the three FSERs were assessed on a larger panel of the first-trimester pregnant women. Material and Methods: This study was conducted with maternal plasma collected from 167 pregnant women carrying 155 chromosomally normal and 12 T21 fetuses (10–13 gestational weeks). Accuracies of FSERs for noninvasive prenatal test of fetal T21 were estimated by the area under the receiver operator characteristic curve (AUC). Results: The levels of all FSERs increased in pregnant women with T21 fetuses when compared with controls (p < 0.001 for all). The levels of the three FSERs did not differ according to maternal age, body mass index, and fetal sex at maternal blood sampling (p > 0.05 for all). In noninvasive fetal T21 detection, the AUC of FSER1, FSER2, and FSER3 were 0.859 (95% CI: 0.746–0.972), 0.919 (95% CI: 0.856–0.982), and 0.868 (95% CI: 0.746–0.990), respectively. Discussion: The findings of this study suggest that all FSERs may be useful for noninvasive fetal T21 detection, regardless of maternal age, body mass index, and fetal sex. | 2022-02-11T21:50:36.012Z |
30,956,463 | {
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"DOI": "10.1093/CLINCHEM/26.8.1178",
"MAG": "1934308035",
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"url": null
} | We describe simple and precise methods for the determination of inorganic sulfate, ester sulfate, and total sulfur in urine. The methods are based on turbidimetry of sulfate as barium sulfate in the presence of a small amount of preformed barium sulfate and with polyethylene glycol as a stabilizing agent. Inorganic sulfate is directly determined, whereas ester sulfate is measured after removal of inorganic sulfate, followed by acid hydrolysis. Total sulfur is determined after wet oxidation of the sample with nitric acid and perchloric acid in the presence of vanadate as a catalyst. We also report excretion values for healthy persons on a self-selected diet. Men excrete significantly higher amounts of inorganic sulfate and total sulfur than women, but this sex-related difference becomes insignificant if excretion values are expressed relative to creatinine. | 2022-12-21T05:18:48.313Z |
95,436,563 | {
"externalids": {
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"DOI": "10.1021/JE900716Q",
"MAG": "2021860166",
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} | The solubilities and diffusion coefficients of hydrogen sulfide and carbon dioxide gases in the ionic liquid (IL) 1-(2-hydroxyethyl)-3-methylimidazolium tetrafluoroborate ([hemim][BF4]), at temperatures ranging from (303.15 to 353.15) K and pressures up to 1.1 MPa, were determined. The solubility data were correlated using the Krichevsky−Kasarnovsky equation, and Henry’s law constants at different temperatures were obtained. From the solubility data, the partial molar thermodynamic functions of solution such as Gibbs energy, enthalpy, and entropy were calculated. The diffusion coefficients were obtained for H2S and CO2 using a semi-infinite volume approach, and a correlation equation with temperature is presented for each gas. A comparison showed that the solubility of H2S was about three times its magnitude, and its diffusion coefficient is of the same order of magnitude as that of CO2 in the IL studied in this work. | 2022-12-25T17:24:25.306Z |
255,188,711 | {
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"ArXiv": null,
"DOI": "10.1109/ICCASIT55263.2022.9986896",
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} | With the development of neural networks in the field of image processing, deblurring is one of the important tasks of image processing, more and more excellent models have appeared one after another. We propose a classification-based strategy that assumes and verifies that the blurred images can be divided into different categories, and then feeds the blur images to the corresponding deblur models after classification. Our classification-based method can generally improve the performance of the current deblur models. After experimental verification, for the same dataset, our method improves PSNR from 30.26 to 31.15 and SSIM from 0.9342 to 0.9374. | 2022-12-29T19:03:19.404Z |
144,936,055 | {
"externalids": {
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"DOI": "10.1002/LIA.4070090301",
"MAG": "2075281520",
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} | What might happen when promising managers plan their development in terms of challenging assignments, leadership qualities, and the avoidance of derailment? A card sort technique developed by the authors at Syntex Corp. is beginning to give answers that are leading managers to a broader view of their development. | 2022-02-09T06:43:03.222Z |
73,912,473 | {
"externalids": {
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"ArXiv": null,
"DOI": "10.1111/1467-6427.00208",
"MAG": "2164998505",
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},
"license": null,
"status": "BRONZE",
"url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1467-6427.00208"
} | There is a strong argument for further developing family therapy as a profession within the NHS, using the mechanisms for workforce planning at regional and national levels. Family therapy can be a full-time occupation, as a profession and a secondary activity, as systemic practice. There is ambivalence about professionalism within the field and at different levels of society. This article outlines areas of tension between family therapy and government policies which focus on evidence-based practice. Full integration into the NHS is possible through the career structure which links family therapy with clinical psychology, adult and child psychotherapy, and provides a model for linking workforce planning with education. There are risks of family therapy becoming marginalized in the future, as a profession or as systemic practice, unless it connects better with workforce planning. | 2022-08-29T11:18:55.672Z |
147,695,980 | {
"externalids": {
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"ArXiv": null,
"DOI": "10.2307/2095191",
"MAG": "2315118706",
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} | This paper explores changing patterns of class mobility in the city of Toulouse, France during the middle decades of the nineteenth century. Class categories are used to map out mobility patterns across locations in the social relations of production rather than across locations in status hierarchies. Data on patterns of intergenerational mobility derived from the marriage records of 1830 and 1872 are used to document the rigidity of class boundaries at different points in time, the sources of recruitment for newly emerging working-class positions, and the impact of changes in production relations upon the character and meaning of mobility patterns. Changes in mobility patterns are situated within the historical context of the changing social relations of production that marked the rise of early industrial capitalism. The final section of the paper provides some hypotheses regarding the impact of changing mobility patterns upon the process of class formation. | 2022-09-14T06:54:40.461Z |
143,205,930 | {
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"DOI": "10.1075/clu.17.03lup",
"MAG": "1901115804",
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} | This chapter aims at redressing the deplorable fact that African languages,their social life and vitality, are assessed according to ideas of Africa groundedin Western language ideologies and based and on language criteria developedbased on American and Australian contexts of language endangerment. Thechapter challenges the validity of these ideologies to account for language usein African setting and starts out by providing the necessary background on thehistory of description of African languages and on assumptions on their vitalityas driven by colonial actors. It then paints a radically different picture of Africanlanguages by looking at them as codes in the multilingual repertoires of thelanguage ecologies in which they are used and by describing the social factorsthat nurture the astonishing linguistic diversity on the continent. In order todo justice to the specificity of African language situations, where settlementcolonies creating the conflictual polyglossic situations typical for Americaand Australia remain an exception, an alternative set of vitality parameters forAfrican languages is proposed. The chapter closes with the observation thatmultilingual language use as a socially embedded practice in complex linguisticecologies needs to become a focus of descriptive and documentary research onAfrican languages. | 2022-09-15T05:59:16.755Z |
36,273,182 | {
"externalids": {
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"DOI": "10.1111/j.1365-2567.2005.02161.x",
"MAG": "2021651983",
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},
"license": null,
"status": "GREEN",
"url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782167"
} | CD200 (OX2) is a membrane glycoprotein that interacts with a structurally related receptor (CD200R) involved in the regulation of macrophage function. The interaction is of low affinity (KD ∼ 1 μm) but can be detected using CD200 displayed in a multivalent form on beads or with dimeric fusion proteins consisting of the extracellular region of CD200 and immunoglobulin Fc regions. We prepared putative pentamers and trimers of mouse CD200 with sequences from cartilage oligomeric matrix protein (COMP) and surfactant protein D (SP‐D), respectively. The COMP protein gave high‐avidity binding and was a valuable tool for showing the interaction whilst the SP‐D protein gave weak binding. In vivo experiments showed that an agonistic CD200R monoclonal antibody caused some amelioration in a model of experimental autoimmune encephalomyelitis but the COMP protein was cleared rapidly and had minimal effect. Pentameric constructs also allowed detection of the rat CD48/CD2 interaction, which is of much lower affinity (KD ∼ 70 μm). These reagents may have an advantage over Fc‐bearing hybrid molecules for probing cell surface proteins without side‐effects due to the Fc regions. The CD200‐COMP gave strong signals in protein microarrays, suggesting that such reagents may be valuable in high throughput detection of weak interactions. | 2022-12-03T10:44:31.792Z |
95,257,910 | {
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"ArXiv": null,
"DOI": "10.1002/crat.201300330",
"MAG": "2032302394",
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} | Unfilled and ytterbium (Yb)‐filled cobalt antimony (CoSb3) nanoparticles were synthesized via solvothermal route using sodium borohydride (NaBH4) as a reducing agent. The effect of various amounts of sodium borohydride on the formation of as‐synthesized CoSb3 nanoparticles with pure phase was investigated. It is found that a sufficient amount of NaBH4 was required in order to form pure phase CoSb3. In addition, the effect of annealing time and temperature on the phase transformation of the as‐prepared non‐pure phase CoSb3 sample was also investigated. It is found that annealing at 500 °C for 5 h would eliminate those non‐CoSb3 phases and result in pure cubic skutterudite phase CoSb3. Structural characterization of the as‐prepared unfilled and Yb‐filled nanoparticles was carried out with transmission electron microscopy (TEM) which revealed the formation of highly crystalline cubic phase of skutterudite Yb‐filled CoSb3. Laser induced breakdown spectroscopy (LIBS) confirmed the presence of ytterbium in the Yb‐filled CoSb3 samples. | 2022-12-19T07:07:33.729Z |
119,210,608 | {
"externalids": {
"ACL": null,
"ArXiv": "1811.05920",
"DOI": "10.1051/0004-6361/201834643",
"MAG": "2901350020",
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},
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"status": "BRONZE",
"url": "https://www.aanda.org/articles/aa/pdf/2019/03/aa34643-18.pdf"
} | A low-amplitude periodic signal in the radial velocity (RV) time series of Barnard’s Star was recently attributed to a planetary companion with a minimum mass of ~3.2 M⊕ at an orbital period of ~233 days. The relatively long orbital period and the proximity of Barnard’s Star to the Sun raises the question whether the true mass of the planet can be constrained by accurate astrometric measurements. By combining the assumption of an isotropic probability distribution of the orbital orientation with the RV-analysis results, we calculated the probability density function of the astrometric signature of the planet. In addition, we reviewed the astrometric capabilities and limitations of current and upcoming astrometric instruments. We conclude that Gaia and the Hubble Space Telescope (HST) are currently the best-suited instruments to perform the astrometric follow-up observations. Taking the optimistic estimate of their single-epoch accuracy to be ~30μas, we find a probability of ~10% to detect the astrometric signature of Barnard’s Star b with ~50 individual-epoch observations. In case of no detection, the implied mass upper limit would be ~8 M⊕, which would place the planet in the super-Earth mass range. In the next decade, observations with the Wide-Field Infrared Space Telescope (WFIRST) may increase the prospects of measuring the true mass of the planet to ~99%. | 2022-12-23T02:06:23.746Z |
154,352,721 | {
"externalids": {
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"DOI": "10.1108/13563280110409854",
"MAG": "2072087631",
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} | Recent academic work has introduced a series of innovative concepts to the branding debate. In particular, the concept of brands that are embedded throughout the organisation has come to the fore. This paper uses a literature review and three mini‐case studies to explore the issues in the branding debate and to illustrate how brand management is changing in response to market and environmental changes. | 2022-12-26T20:21:54.599Z |
109,808,035 | {
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"DOI": "10.26507/REI.V7N13.196",
"MAG": "1560330837",
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} | For small and medium enterprises in dairy sector engaged in yogurt manufacture and considering the new economic challenges imposed by economy globalization, result necessary for their industrial processes respond to these needs. Importantly, processing of dairy products like yogurt, demands a thorough knowledge of all factors and variables involved in each stage of production process, starting with raw materials ingress until to obtain final product, which must fulfill strict operating sequence. Therefore, industrial processes modeling using simulation tools such as finite automata let to automate processes, to increase productivity, to improve quality of finished products and to reduce risk factors. Occupational risks lead to machines processes accidents which involve critical variables, such as high temperatures, use of strong acids, pathogenic microorganisms, radiation and toxic compounds. This paper shows a development of a finite automata model as an alternative solution for process´s automation in yogurt production in small and medium enterprises. The presented model has a great versatility, allowing select the kind of yogurt to make options such as: whole yogurt, skim yogurt and nonfat yogurt. For the pasteurization process options offered are: ultra-pasteurization, continuous flow and discontinuous. Another feature offered is presented in the selection of additives, allowing to choose a flavored product, natural or fruity. The different characteristics of production process are collected in the matrix of states, the table process and the phased array, which are basis for development of finite automata model proposed. | 2022-01-27T12:30:03.732Z |
45,288,526 | {
"externalids": {
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"ArXiv": null,
"DOI": "10.4172/2155-6121.1000135",
"MAG": "2331474502",
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},
"license": "CCBY",
"status": "HYBRID",
"url": "https://www.omicsonline.org/cooperation-of-mast-cells-and-basophils-in-allergy-2155-6121.1000135.pdf"
} | Mast cells and basophils are granulated cells, which share similar phenotypic and functional properties. They express complementary and partially overlapping roles in acquired and innate immunity, including both effector and regulatory activities, but they also display important distinctive features as to developmental lineage, mediator content, and function. They cooperate in expanding and/or modulating inflammation as well as in mediating subsequent tissue repair. Mast cells release in the inflammatory scenario a series of potent proangiogenic molecules that stimulate vessel sprouting and new vessel formation. Recent data suggest that basophils may also play a role in inflammation-related angiogenesis, principally but not exclusively through the expression of several forms of VEGF and their receptors. This review focuses on the potential cooperative link between mast cells and basophils in promoting angiogenesis during allergic inflammation. We discuss the multifaceted roles of mast cells and basophils in the inflammatory setting during allergic diseases and whether these cells can be both source and target cells for proangiogenic mediators. | 2022-09-01T23:10:13.252Z |
59,477,208 | {
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"DOI": "10.1155/S1110662X01000071",
"MAG": "2126804139",
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} | The application of atomic force microscopy (AFM) to solid-state photodimerizations revealed previously
unexpected long-range molecular movements in the initial stages (phase rebuilding) and in the final
stages (phase transformation and disintegration) of reaction. The consequences for the new understanding
of solid-state photochemistry are discussed. The 4.2 A criterion of organic topochemistry lacks a real basis
and is not applicable to regular photolyses, even under tail irradiation conditions for instance of α-cinnamic acid or in E/Z-isomerizations in the crystal bulk. The experimental observation of molecular movements in
reacting crystals requires more elaborate use of X-ray structural data by invoking the molecular packing. If a
crystal keeps its outer form upon photolysis this does not necessarily indicate a topotactic transformation,
and submicroscopically resolved AFM investigations are in order. The applications of molecular movements
or non-photoreactivities due to the prevention of movements by 3D-interlocked packing have numerous
applications. Thus, amorphous solids or inclusion compounds may enable the movements in these cases.
Hitherto puzzling E/Z-photoisomerizations in the crystalline state can now be mechanistically understood.
In some cases even rotational mechanisms can be modelled in combination with the movements. In others
the space saving twist mechanism is the only choice. The benefits of the new solid-state mechanisms for
crystal engineering, photochromism, mixed crystals, absolute asymmetric syntheses, and preparative photochemistry
derive from its experimental basis. Numerous presumed puzzles from the postulate of minimal
atomic and molecular movement vanish in a straightforward manner. | 2022-12-17T09:54:56.650Z |
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