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although treatment results in solid tumors are disappointing , tumor regression greater than 50 % is achieved in 15-25 % of patients with hypernephroma or melanoma , cancers highly resistant to cytotoxic drugs . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid",
"pos": [
30,
35
]
} | {
"id": "C0025202",
"name": "melanoma",
"pos": [
155,
163
]
} |
the co2 laser appears to be particularly useful to excise solid tumours , such as meningiomas and neurinomas . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid",
"pos": [
58,
63
]
} | {
"id": "C0025286",
"name": "meningiomas",
"pos": [
82,
93
]
} |
these new analogs were found to be markedly superior to methotrexate against four of five ascites tumors ( l1210 leukemia , sarcoma 180 , ehrlich carcinoma and tapper carcinosarcoma ) and against four of five solid tumors ( s180 , tapper carcinosarcoma , e0771 mammary adenocarcinoma , lewis lung carcinoma , and t241 sarcoma ) . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
209,
221
]
} | {
"id": "C1261473",
"name": "sarcoma",
"pos": [
318,
325
]
} |
three hundred one patients with solid tumors ( breast , lung , melanoma , sarcoma , primary brain , testicular , hypernephroma and others ) experienced 5063 days of thrombocytopenia ( platelet count less than 50,000/microliters ) and 670 days of severe thrombocytopenia ( platelet count less than 20,000/microliters ) . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
32,
44
]
} | {
"id": "C0025202",
"name": "melanoma",
"pos": [
63,
71
]
} |
three hundred one patients with solid tumors ( breast , lung , melanoma , sarcoma , primary brain , testicular , hypernephroma and others ) experienced 5063 days of thrombocytopenia ( platelet count less than 50,000/microliters ) and 670 days of severe thrombocytopenia ( platelet count less than 20,000/microliters ) . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
32,
44
]
} | {
"id": "C1261473",
"name": "sarcoma",
"pos": [
74,
81
]
} |
antibodies which are directed against human tumor-associated antigens can potentially be used as carriers of radioactivity for in vivo diagnosis ( radioimmunodetection ) or treatment ( radioimmunotherapy ) of solid tumors , including colon , hepatoma , cholangiocarcinoma , and melanoma . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
209,
221
]
} | {
"id": "C0206698",
"name": "cholangiocarcinoma",
"pos": [
253,
271
]
} |
antibodies which are directed against human tumor-associated antigens can potentially be used as carriers of radioactivity for in vivo diagnosis ( radioimmunodetection ) or treatment ( radioimmunotherapy ) of solid tumors , including colon , hepatoma , cholangiocarcinoma , and melanoma . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
209,
221
]
} | {
"id": "C0025202",
"name": "melanoma",
"pos": [
278,
286
]
} |
lactate production and oxygen consumption were studied in single cell suspension prepared from solid tumours of the black-melanotic ( ma ) , brown-melanotic ( mi ) and amelanotic ( ab ) melanomas of hamster . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumours",
"pos": [
95,
108
]
} | {
"id": "C0025202",
"name": "hamster",
"pos": [
199,
206
]
} |
the major part of this probe could be hybridized to rnas from all the human neoplasias studied : cultured cell lines derived from leukemias , malignant lymphomas or sarcomas , leukemic cells or solid tumors ( sarcomas and carcinomas ) recovered from patients . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
194,
206
]
} | {
"id": "C1261473",
"name": "sarcomas",
"pos": [
209,
217
]
} |
compared with other solid tumours in childhood , neuroblastomas show a marked tendency to metastasise to the skeleton . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumours",
"pos": [
20,
33
]
} | {
"id": "C0027819",
"name": "neuroblastomas",
"pos": [
49,
63
]
} |
a two-step procedure for releasing cells from solid tumors has been applied to specimens of human melanoma , sarcoma , lung , colon , and breast carcinoma . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
46,
58
]
} | {
"id": "C1261473",
"name": "sarcoma",
"pos": [
109,
116
]
} |
[ solid tumor ( embryonal abdominal carcinoma ) clinically cured with only one dose of a cytostatic ( natulan ) . a new indication for ibenzmethyzin ] . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumor",
"pos": [
2,
13
]
} | {
"id": "C0206659",
"name": "embryonal",
"pos": [
16,
25
]
} |
the daunorubicin-poly-l-aspartic acid conjugate demonstrated antitumor activity comparable to that of doxorubicin in leukemia models , but superior to that of doxorubicin in a solid tumor model ( ms-2 sarcoma ) . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumor",
"pos": [
176,
187
]
} | {
"id": "C1261473",
"name": "sarcoma",
"pos": [
201,
208
]
} |
a review of the literature indicates that black children in the united states have a lower overall incidence of cancer and are less prone to leukemia and certain solid tumors , including neuroblastoma , rhabdomyosarcoma , ewing 's sarcoma , testicular tumors , liver tumors , and malignant melanoma , than are white children . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
162,
174
]
} | {
"id": "C0027819",
"name": "neuroblastoma",
"pos": [
187,
200
]
} |
a review of the literature indicates that black children in the united states have a lower overall incidence of cancer and are less prone to leukemia and certain solid tumors , including neuroblastoma , rhabdomyosarcoma , ewing 's sarcoma , testicular tumors , liver tumors , and malignant melanoma , than are white children . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
162,
174
]
} | {
"id": "C0035412",
"name": "rhabdomyosarcoma",
"pos": [
203,
219
]
} |
a review of the literature indicates that black children in the united states have a lower overall incidence of cancer and are less prone to leukemia and certain solid tumors , including neuroblastoma , rhabdomyosarcoma , ewing 's sarcoma , testicular tumors , liver tumors , and malignant melanoma , than are white children . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
162,
174
]
} | {
"id": "C0553580",
"name": "ewing 's",
"pos": [
222,
230
]
} |
a review of the literature indicates that black children in the united states have a lower overall incidence of cancer and are less prone to leukemia and certain solid tumors , including neuroblastoma , rhabdomyosarcoma , ewing 's sarcoma , testicular tumors , liver tumors , and malignant melanoma , than are white children . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
162,
174
]
} | {
"id": "C0025202",
"name": "malignant melanoma",
"pos": [
280,
298
]
} |
in tests against murine and human solid tumors implanted s.c. in normal mice and nude mice , respectively , fk973 ( i.v . ) inhibited growth of murine tumors ( m5076 sarcoma , colon 38 carcinoma , b16 melanoma , and lewis lung carcinoma ) by 66-100 % and human tumors ( lx-1 lung , mx-1 mammary , and sc-6 stomach carcinoma ) by 84-99 % . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
34,
46
]
} | {
"id": "C1261473",
"name": "sarcoma",
"pos": [
166,
173
]
} |
in tests against murine and human solid tumors implanted s.c. in normal mice and nude mice , respectively , fk973 ( i.v . ) inhibited growth of murine tumors ( m5076 sarcoma , colon 38 carcinoma , b16 melanoma , and lewis lung carcinoma ) by 66-100 % and human tumors ( lx-1 lung , mx-1 mammary , and sc-6 stomach carcinoma ) by 84-99 % . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
34,
46
]
} | {
"id": "C0699791",
"name": "stomach carcinoma",
"pos": [
306,
323
]
} |
four patients suffered from hematologic diseases ( two cases of refractory anemia with excess of blasts and one case each of acute myeloblastic leukemia and burkitt lymphoma ) , and two had solid tumors ( retinoblastoma and ewing 's sarcoma ) . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
190,
202
]
} | {
"id": "C0035335",
"name": "retinoblastoma",
"pos": [
205,
219
]
} |
four patients suffered from hematologic diseases ( two cases of refractory anemia with excess of blasts and one case each of acute myeloblastic leukemia and burkitt lymphoma ) , and two had solid tumors ( retinoblastoma and ewing 's sarcoma ) . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
190,
202
]
} | {
"id": "C0553580",
"name": "ewing 's sarcoma",
"pos": [
224,
240
]
} |
the effect of an intratumor injection of thrombin as a potential cancer therapeutic agent was examined in two transplantable solid tumor models : a renal adenocarcinoma implanted beneath the kidney capsule in wistar-lewis rats and a rhabdomyosarcoma implanted similarly in wag-rij rats . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumor",
"pos": [
125,
136
]
} | {
"id": "C0035412",
"name": "rhabdomyosarcoma",
"pos": [
233,
249
]
} |
establishment and its characteristics of a nude mice solid tumor model nhg-1 from human glioma cell line are reported . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumor",
"pos": [
53,
64
]
} | {
"id": "C0017638",
"name": "glioma",
"pos": [
88,
94
]
} |
interferon and interferon-inducers have been found to alter the course of solid tumors , leukemia , sarcomas and lymphomas in experimental animals , possibly by stimulating the reticuloendothelial system to produce tumor rejection or by altering the surface of cells to change tumor and host reactions . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
74,
86
]
} | {
"id": "C1261473",
"name": "sarcomas",
"pos": [
100,
108
]
} |
since functional characterization of nonpurified enzymes is not the most accurate means for distinguishing different molecular forms of an enzyme , we have partially purified the enzymes from the ascitic ( embryoid body ) and solid tumor forms of the ott-6050 teratoma line , and utilized the technique of electrophoresis in polyacrylamide gels to compare the teratoma enzyme with isozymes from kidney and placenta . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumor",
"pos": [
226,
237
]
} | {
"id": "C0039538",
"name": "teratoma",
"pos": [
360,
368
]
} |
disaggregated cell suspensions made from transplanted solid tumors , either chemically-induced fibrosarcomas , or spontaneous mammary carcinomas , can contain very high numbers of fc receptor-bearing cells which are of host origin . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
54,
66
]
} | {
"id": "C0678222",
"name": "mammary carcinomas",
"pos": [
126,
144
]
} |
extended screening of 13a showed it to be active against solid tumors such as m5076 sarcoma , b16 melanoma , and colon 38 carcinoma . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
57,
69
]
} | {
"id": "C1261473",
"name": "sarcoma",
"pos": [
84,
91
]
} |
interferon alfa has proven efficacious in treating certain hematologic malignancies and solid tumors and has recently been indicated for acquired immunodeficiency syndrome ( aids ) -related kaposi 's sarcoma . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
88,
100
]
} | {
"id": "C0036220",
"name": "kaposi 's sarcoma",
"pos": [
190,
207
]
} |
dna samples from 79 patients with solid tumors ( 63 mesenchymal tumors , 12 lung carcinomas , 4 breast carcinomas ) were examined and compared with dna samples from 50 leukemia patients and 14 unrelated individuals without malignant neoplasms . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
34,
46
]
} | {
"id": "C0684249",
"name": "lung carcinomas",
"pos": [
76,
91
]
} |
dna samples from 79 patients with solid tumors ( 63 mesenchymal tumors , 12 lung carcinomas , 4 breast carcinomas ) were examined and compared with dna samples from 50 leukemia patients and 14 unrelated individuals without malignant neoplasms . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
34,
46
]
} | {
"id": "C0678222",
"name": "breast carcinomas",
"pos": [
96,
113
]
} |
in four patients with solid tumors ( three small cell lung cancers , one germ cell cancer ) high dose chemotherapy with autologous bone marrow infusion was given . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
22,
34
]
} | {
"id": "C0149925",
"name": "small cell lung cancers",
"pos": [
43,
66
]
} |
this suppressive activity has been demonstrated with several solid tumors including breast ca , colon ca , melanoma , uterine ca , and ovarian ca . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
61,
73
]
} | {
"id": "C0025202",
"name": "melanoma",
"pos": [
107,
115
]
} |
- a solid tumour was found in 13 of the patients , eight were renal tumours and five neuroblastomas . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumour",
"pos": [
4,
16
]
} | {
"id": "C0027819",
"name": "neuroblastomas",
"pos": [
85,
99
]
} |
herpes zoster , a rare complication in patients with solid tumours , was observed in 13 of 161 ( 8.1 % ) patients with small-cell anaplastic carcinoma of the lung treated in a prospective combined modality therapy trial . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumours",
"pos": [
53,
66
]
} | {
"id": "C0149925",
"name": "small-cell",
"pos": [
119,
129
]
} |
[ content of bruneomycin in solid tumors and ascites of albino mice with transplanted sarcoma crocker and lymphadenosis ( strain l-5178 fisher ) ] . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
28,
40
]
} | {
"id": "C1261473",
"name": "sarcoma",
"pos": [
86,
93
]
} |
influence of systematic errors on the evaluation of the s phase portions from dna distributions of solid tumors as shown for 328 breast carcinomas . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
99,
111
]
} | {
"id": "C0678222",
"name": "breast carcinomas",
"pos": [
129,
146
]
} |
a preliminary survey of specimens from 12 solid tumor types in our laboratories indicates significant overexpression of p-glycoprotein in some sarcomas . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumor",
"pos": [
42,
53
]
} | {
"id": "C1261473",
"name": "sarcomas",
"pos": [
143,
151
]
} |
content analysis of the neoplastic-related items disclosed a preponderance of questions related to gynecologic cancer with few questions concerning the major solid tumors : lung , breast and colorectal cancer . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
158,
170
]
} | {
"id": "C0009402",
"name": "colorectal cancer",
"pos": [
191,
208
]
} |
an in vitro soft agar technique was used to culture human malignant melanoma cells from 61 solid tumors , 17 lymph nodes , 11 effusions , and four bone marrow specimens from 93 patients with malignant melanoma . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
91,
103
]
} | {
"id": "C0025202",
"name": "malignant melanoma",
"pos": [
191,
209
]
} |
primary diseases in this series of 76 cases included 37 cases of hematological disorders ( acute leukemia in 25 cases , malignant lymphoma in 7 cases , aplastic anemia in 3 cases and 2 other diseases ) and 38 cases of solid tumors ( lung cancer in 7 cases , gastric cancer in 11 cases , esophageal cancer in 6 cases , pancreatic cancer in 3 cases , bile duct cancer in 4 cases , hepatocellular cancer in 3 cases , and 4 other diseases ) . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
218,
230
]
} | {
"id": "C0235974",
"name": "pancreatic cancer",
"pos": [
318,
335
]
} |
primary diseases in this series of 76 cases included 37 cases of hematological disorders ( acute leukemia in 25 cases , malignant lymphoma in 7 cases , aplastic anemia in 3 cases and 2 other diseases ) and 38 cases of solid tumors ( lung cancer in 7 cases , gastric cancer in 11 cases , esophageal cancer in 6 cases , pancreatic cancer in 3 cases , bile duct cancer in 4 cases , hepatocellular cancer in 3 cases , and 4 other diseases ) . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
218,
230
]
} | {
"id": "C0740277",
"name": "bile duct cancer",
"pos": [
349,
365
]
} |
the spin labeled derivatives of podophyllotoxin , 4- [ 4 '' - ( 2 '' ,2 '' ,6 '' ,6 '' -tetramethyl-l '' -piperidinyloxy ) amino ] -4'-demethylepipodophyllotoxin ( gp-7,3 ) and n-podophyllic acid-n '' - [ 4- ( 2,2,6,6-tetramethyl-l-piperidinyloxy ) ] thiosemicarbazide ( gp-4,5 ) were synthesized and tested for their anticancer activity against the mouse solid tumors s180 and hepa in vivo , and the mouse lymphocytic leukemia l1210 and human stomach carcinoma sgc-7901 cells in vitro . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
356,
368
]
} | {
"id": "C0699791",
"name": "stomach carcinoma",
"pos": [
444,
461
]
} |
studies with at least four metastatic and uniformly fatal murine solid tumors ( lung , breast , colon , and melanoma ) have demonstrated significantly improved cure rates with drug treatment following surgical removal of the grossly apparent primary tumor than can be obtained with either surgery or drug treatment when used alone . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
65,
77
]
} | {
"id": "C0025202",
"name": "melanoma",
"pos": [
108,
116
]
} |
lymphoid cells associated with solid tumor tissues or effusions have usually low nk cytotoxicity , with considerable differences among histologic types ( e.g. , nasopharyngeal carcinoma versus other tumors ) or at different sites involved by the same tumor ( e.g. , peritoneal effusions versus solid lesions in ovarian carcinoma ) . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumor",
"pos": [
31,
42
]
} | {
"id": "C2931822",
"name": "nasopharyngeal carcinoma",
"pos": [
161,
185
]
} |
the solid tumors included three multicentric hamartomas , three sarcomas of undetermined histogenesis , and one immature teratoma . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
4,
16
]
} | {
"id": "C1261473",
"name": "sarcomas",
"pos": [
64,
72
]
} |
in contrast , monocytes from patients with solid tumors , including carcinomas of breast and gastrointestinal and genitourinary tracts , had peak cl values ( 22.4 +/- 1.6 x 10 ( 3 ) which were not significantly different from controls . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
43,
55
]
} | {
"id": "C0678222",
"name": "carcinomas of breast",
"pos": [
68,
88
]
} |
seven children with advanced solid tumors ( 2 rhabdomyosarcomas , 2 ewing 's sarcomas , 1 astrocytoma , 1 t cell lymphoma and 1 neuroblastoma ) received high dose chemotherapy and/or radiotherapy followed by autologous bone marrow transplantation . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
29,
41
]
} | {
"id": "C0035412",
"name": "rhabdomyosarcomas",
"pos": [
46,
63
]
} |
seven children with advanced solid tumors ( 2 rhabdomyosarcomas , 2 ewing 's sarcomas , 1 astrocytoma , 1 t cell lymphoma and 1 neuroblastoma ) received high dose chemotherapy and/or radiotherapy followed by autologous bone marrow transplantation . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
29,
41
]
} | {
"id": "C0004114",
"name": "astrocytoma",
"pos": [
90,
101
]
} |
seven children with advanced solid tumors ( 2 rhabdomyosarcomas , 2 ewing 's sarcomas , 1 astrocytoma , 1 t cell lymphoma and 1 neuroblastoma ) received high dose chemotherapy and/or radiotherapy followed by autologous bone marrow transplantation . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
29,
41
]
} | {
"id": "C0027819",
"name": "neuroblastoma",
"pos": [
128,
141
]
} |
22.8 % of the patients with solid tumors ( excluding brain tumors ) in childhood were soft tissue sarcomas . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
28,
40
]
} | {
"id": "C1261473",
"name": "soft tissue sarcomas",
"pos": [
86,
106
]
} |
and ( c ) four solid tumors sensitive to doxorubicin ( b16 melanoma , b16v melanoma line , m5076 reticulum cell sarcoma , and lewis lung carcinoma ) . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
15,
27
]
} | {
"id": "C0025202",
"name": "line",
"pos": [
84,
88
]
} |
the radioprotective drug , wr-2721 ( s,2- [ 3-aminopropylamino ] ethyl-phosphorothioic acid ) , has been studied in terms of its ability to ( a ) protect mice against mechlorethamine ( hn2 ) -induced hematopoietic death , and ( b ) alter the ability of hn2 injections to induce growth delay in a solid tumor , the line 1 lung carcinoma . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumor",
"pos": [
296,
307
]
} | {
"id": "C0684249",
"name": "lung",
"pos": [
321,
325
]
} |
subsequent solid tumors have occurred in six patients from 5 to 21 years after treatment , including papillary carcinoma of the thyroid , renal cell carcinoma , unilateral breast carcinoma , cervix carcinoma in situ , and lung carcinoma after ra , and bilateral breast carcinoma after cb . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
11,
23
]
} | {
"id": "C0684249",
"name": "lung carcinoma",
"pos": [
222,
236
]
} |
one pattern involves solid tumors , which have not been stressed and which include malignancies in the oral cavity , breast , stomach , pancreas , ovary , and bladder . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
21,
33
]
} | {
"id": "C0151546",
"name": "malignancies",
"pos": [
83,
95
]
} |
protein kinase ckii ( i.e . casein kinase ii , ckii , nii ) is expressed at a higher level in rapidly proliferating tissues and in solid human tumours ( e.g . colorectal carcinomas ) when compared to the corresponding non-neoplastic colorectal mucosa . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid",
"pos": [
131,
136
]
} | {
"id": "C0009402",
"name": "colorectal carcinomas",
"pos": [
159,
180
]
} |
it is only in the case of curable solid tumors ( for example : carcinoma of the testis , choriocarcinoma ) that a reduction phase is possible and this behaviour is justified in avoiding the iatrogenic effects of chemotherapy . | special_category_includes_neoplasm | {
"id": "C0280100",
"name": "solid tumors",
"pos": [
34,
46
]
} | {
"id": "C0008497",
"name": "choriocarcinoma",
"pos": [
89,
104
]
} |
sera from melanoma patients , healthy donors , pregnant women and patients with types of tumors other than melanoma were tested on various melanoma lines as well as on a cultured brain tumor and adult skin fibroblasts , using a microimmune adherence test . | subset_includes_concept | {
"id": "C2981607",
"name": "types",
"pos": [
80,
85
]
} | {
"id": "C0025202",
"name": "lines",
"pos": [
148,
153
]
} |
after a short survey of the existing literature , the authors discuss the influence of the dose , the relatively long latent time and the different tissular tumor types ( carcinomas and sarcomas ) in dependence on the age of the patient at the time of irradiation . | subset_includes_concept | {
"id": "C2981607",
"name": "tumor types",
"pos": [
157,
168
]
} | {
"id": "C0007097",
"name": "carcinomas",
"pos": [
171,
181
]
} |
after a short survey of the existing literature , the authors discuss the influence of the dose , the relatively long latent time and the different tissular tumor types ( carcinomas and sarcomas ) in dependence on the age of the patient at the time of irradiation . | subset_includes_concept | {
"id": "C2981607",
"name": "tumor types",
"pos": [
157,
168
]
} | {
"id": "C1261473",
"name": "sarcomas",
"pos": [
186,
194
]
} |
in an group of meningiomas alpha-1 organ specific brain antigen was detected in tumors of meningotheliomatous type , but it was absent in tumors of mixed and fibroblastic type , this permitted suggesting a neuroectodermal origin of tumors of the first type and ectomesenchymal one of the second type . | subset_includes_concept | {
"id": "C2981607",
"name": "tumors",
"pos": [
80,
86
]
} | {
"id": "C0026277",
"name": "tumors",
"pos": [
232,
238
]
} |
twenty-six tumours of the seminoma type and 54 embryonic carcinomas of the testis were studied with immunoperoxidase , using an anti-beta hcg immune serum and an anti-alpha fp immune serum . | subset_includes_concept | {
"id": "C2981607",
"name": "tumours",
"pos": [
11,
18
]
} | {
"id": "C0036631",
"name": "seminoma",
"pos": [
26,
34
]
} |
although no mucin-secreting cells were detected in the donor carcinoid , the cheek pouch transplants exclusively exhibited mucinsecreting tumour cells of signet-ring type consistent with adenocarcinoma . | subset_includes_concept | {
"id": "C2981607",
"name": "tumour",
"pos": [
138,
144
]
} | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
187,
201
]
} |
though tumors of this type may have a malignant potential , there is evidence to indicate that they may be approached more conservatively than the usual nephroblastoma . | subset_includes_concept | {
"id": "C2981607",
"name": "tumors",
"pos": [
7,
13
]
} | {
"id": "C0027708",
"name": "nephroblastoma",
"pos": [
153,
167
]
} |
many of the scales , including mcgill pain , ces-d depression , and satisfaction with care scales , have been validated in other studies with similar samples . | subset_includes_concept | {
"id": "C2699160",
"name": "ces-d",
"pos": [
45,
50
]
} | {
"id": "C0011570",
"name": "depression",
"pos": [
51,
61
]
} |
the 41 patients diagnosed by the ces-d as depressed had significantly lower scores on mai measures of psychological adjustment , cognitive function , and physical health compared with the nondepressed respondents and were more likely to have had episodes of anxiety and depression in the year before the study . | subset_includes_concept | {
"id": "C2699160",
"name": "ces-d",
"pos": [
33,
38
]
} | {
"id": "C0449820",
"name": "scores",
"pos": [
76,
82
]
} |
the 41 patients diagnosed by the ces-d as depressed had significantly lower scores on mai measures of psychological adjustment , cognitive function , and physical health compared with the nondepressed respondents and were more likely to have had episodes of anxiety and depression in the year before the study . | subset_includes_concept | {
"id": "C2699160",
"name": "ces-d",
"pos": [
33,
38
]
} | {
"id": "C0011570",
"name": "depression",
"pos": [
270,
280
]
} |
four variables -- respondents ' overall physical health as measured by the mai , days spent sick in bed during the past year , living alone , and educational level -- explained some of the variance between the ces-d scores of the depressed and nondepressed patients . | subset_includes_concept | {
"id": "C2699160",
"name": "ces-d",
"pos": [
210,
215
]
} | {
"id": "C0449820",
"name": "scores",
"pos": [
216,
222
]
} |
metastatic instability was dependent on tumor type , with five of six lines of tumor sa-nh , one of four lines of tumor sa-4020 , and possibly one of five lines of hca-i changing in lung metastasis formation . | subset_includes_concept | {
"id": "C2981607",
"name": "tumor type",
"pos": [
40,
50
]
} | {
"id": "C0206669",
"name": "hca",
"pos": [
164,
167
]
} |
using the 1984 supplement on aging to the national health interview survey , this study examined the prevalence and correlates of self-reported everyday memory problems in a sample of persons aged 55 and older ( n = 14,783 ) . | subset_includes_concept | {
"id": "C1513894",
"name": "national health interview survey",
"pos": [
42,
74
]
} | {
"id": "C0001779",
"name": "aged",
"pos": [
192,
196
]
} |
moreover , mfh apparently had frequently been misinterpreted as other tumor types , as for instance rhabdomyosarcoma . | subset_includes_concept | {
"id": "C2981607",
"name": "tumor types",
"pos": [
70,
81
]
} | {
"id": "C0035412",
"name": "rhabdomyosarcoma",
"pos": [
100,
116
]
} |
self-reported consumption was calculated by using data from the national health interview surveys ( nhis ) for adults and from the national household surveys on drug abuse for adolescents . | subset_includes_concept | {
"id": "C1513894",
"name": "national health interview surveys",
"pos": [
64,
97
]
} | {
"id": "C0001675",
"name": "adults",
"pos": [
111,
117
]
} |
self-reported consumption was calculated by using data from the national health interview surveys ( nhis ) for adults and from the national household surveys on drug abuse for adolescents . | subset_includes_concept | {
"id": "C1513894",
"name": "national health interview surveys",
"pos": [
64,
97
]
} | {
"id": "C0020052",
"name": "household",
"pos": [
140,
149
]
} |
this type of tumour has not been reported in ovary , notably in association with a mesodermal mixed tumour . | subset_includes_concept | {
"id": "C2981607",
"name": "type",
"pos": [
5,
9
]
} | {
"id": "C1334603",
"name": "mesodermal mixed tumour",
"pos": [
83,
106
]
} |
the center for epidemiologic studies depression scale and the depression subscale from the general well-being schedule were used as predictors in this 10-year follow-up study of a nationally representative sample . | subset_includes_concept | {
"id": "C2699160",
"name": "center for epidemiologic",
"pos": [
4,
28
]
} | {
"id": "C0011570",
"name": "depression",
"pos": [
62,
72
]
} |
using data from 3 studies of patients with rheumatoid arthritis , we examined the extent to which responses to items in the center for epidemiological studies depression scale ( ces-d ) are influenced by aspects of the disease process other than depression . | subset_includes_concept | {
"id": "C2699160",
"name": "center for epidemiological studies",
"pos": [
124,
158
]
} | {
"id": "C0011570",
"name": "depression",
"pos": [
246,
256
]
} |
our findings suggested that 4 ces-d items ( i.e. , `` '' i felt that everything i did was an effort , '' '' `` '' i felt hopeful about the future , '' '' `` '' my sleep was restless , '' '' and `` '' i could not get going '' '' ) may be influenced by aspects of the disease process and , thus , are not necessarily indicative of depression among persons with arthritis . | subset_includes_concept | {
"id": "C2699160",
"name": "ces-d",
"pos": [
30,
35
]
} | {
"id": "C0015264",
"name": "effor",
"pos": [
93,
98
]
} |
our findings suggested that 4 ces-d items ( i.e. , `` '' i felt that everything i did was an effort , '' '' `` '' i felt hopeful about the future , '' '' `` '' my sleep was restless , '' '' and `` '' i could not get going '' '' ) may be influenced by aspects of the disease process and , thus , are not necessarily indicative of depression among persons with arthritis . | subset_includes_concept | {
"id": "C2699160",
"name": "ces-d",
"pos": [
30,
35
]
} | {
"id": "C0027361",
"name": "g",
"pos": [
10,
11
]
} |
the impact that these items have on the interpretation of ces-d scores was assessed in relation to 2 research issues : estimation of the prevalence and severity of depression in arthritis populations and identification of the determinants of depression among individuals with arthritis . | subset_includes_concept | {
"id": "C2699160",
"name": "ces-d",
"pos": [
58,
63
]
} | {
"id": "C0011570",
"name": "depression",
"pos": [
242,
252
]
} |
the impact that these items have on the interpretation of ces-d scores was assessed in relation to 2 research issues : estimation of the prevalence and severity of depression in arthritis populations and identification of the determinants of depression among individuals with arthritis . | subset_includes_concept | {
"id": "C2699160",
"name": "ces-d",
"pos": [
58,
63
]
} | {
"id": "C0027361",
"name": "individuals",
"pos": [
259,
270
]
} |
this type of tumor is often found as a cicatricial carcinoma in the periphery of the lung . | subset_includes_concept | {
"id": "C2981607",
"name": "type",
"pos": [
5,
9
]
} | {
"id": "C0007097",
"name": "carcinoma",
"pos": [
51,
60
]
} |
fluctuations were observed in the incidence of different tumor types among the groups , but the level of significance was reached only when comparing the incidence of hepatomas , adrenal cortex tumors and subcutaneous fibrosarcomas among males and the incidence of angiomas and angiosarcomas among females . | subset_includes_concept | {
"id": "C2981607",
"name": "tumor types",
"pos": [
57,
68
]
} | {
"id": "C2239176",
"name": "hepatomas",
"pos": [
167,
176
]
} |
fluctuations were observed in the incidence of different tumor types among the groups , but the level of significance was reached only when comparing the incidence of hepatomas , adrenal cortex tumors and subcutaneous fibrosarcomas among males and the incidence of angiomas and angiosarcomas among females . | subset_includes_concept | {
"id": "C2981607",
"name": "tumor types",
"pos": [
57,
68
]
} | {
"id": "C0018923",
"name": "angiosarcomas",
"pos": [
278,
291
]
} |
increased expression of the epidermal growth factor receptor has been noted in many types of tumors and is associated with gene amplification in several including epidermoid carcinoma , lung carcinoma , breast carcinoma and glioblastoma . | subset_includes_concept | {
"id": "C2981607",
"name": "types",
"pos": [
84,
89
]
} | {
"id": "C0007137",
"name": "epidermoid carcinoma",
"pos": [
163,
183
]
} |
this includes patients in whom immunohistochemical studies or electron microscopy , or both , suggest a likely tumor type responsive to systemic therapy , such as prostate cancer , lymphoma , or a neuroendocrine tumor . | subset_includes_concept | {
"id": "C2981607",
"name": "tumor type",
"pos": [
111,
121
]
} | {
"id": "C0024299",
"name": "lymphoma",
"pos": [
181,
189
]
} |
the utility of the center for epidemiologic studies depression scale for children ( ces-dc ) , a modified version of the center for epidemiologic studies depression scale , was explored in a sample of children , adolescents , and young adults at high or low risk for depression according to their parents ' diagnosis . | subset_includes_concept | {
"id": "C2699160",
"name": "center for epidemiologic studies",
"pos": [
19,
51
]
} | {
"id": "C0011570",
"name": "depression",
"pos": [
267,
277
]
} |
in these good responders , long-term maintenance treatment should be individually adjusted since relapse appears to depend upon the type of tumor , the extent of malignancy and the administration of anticancer therapy . | subset_includes_concept | {
"id": "C2981607",
"name": "type",
"pos": [
132,
136
]
} | {
"id": "C0006826",
"name": "malignancy",
"pos": [
162,
172
]
} |
moreover , in the context of our experimental system and a dynamic picture of tumour development where tumour types can be seen as stably arising and continuing entities or , a progressive sequence for which squamous cell carcinoma represents an end stage , it is not appropriate to view the keratoacanthoma-like lesion in mice as an entity distinct from the spectrum of uv induced tumours progressing from benignity to malignancy . | subset_includes_concept | {
"id": "C2981607",
"name": "tumour",
"pos": [
78,
84
]
} | {
"id": "C0007137",
"name": "squamous cell carcinoma",
"pos": [
208,
231
]
} |
moreover , in the context of our experimental system and a dynamic picture of tumour development where tumour types can be seen as stably arising and continuing entities or , a progressive sequence for which squamous cell carcinoma represents an end stage , it is not appropriate to view the keratoacanthoma-like lesion in mice as an entity distinct from the spectrum of uv induced tumours progressing from benignity to malignancy . | subset_includes_concept | {
"id": "C2981607",
"name": "tumour",
"pos": [
78,
84
]
} | {
"id": "C0006826",
"name": "malignancy",
"pos": [
420,
430
]
} |
however , not all types of tumors are increased to the same extent , in that lymphoreticular neoplasias ( especially non-hodgkin 's lymphomas ) , acute leukemias as second tumors and , among solid neoplasms , squamous cell carcinomas are those most frequently reported . | subset_includes_concept | {
"id": "C2981607",
"name": "types",
"pos": [
18,
23
]
} | {
"id": "C0007137",
"name": "squamous cell carcinomas",
"pos": [
209,
233
]
} |
the finding of nodular renal blastema in renal parenchyma with an apparently normal gross appearance is an argument in favor of classifying this type of tumor in the group of nephroblastomas and may explain the tendency of fetal rhabdomyomatous nephroblastoma to occur bilaterally . | subset_includes_concept | {
"id": "C2981607",
"name": "type",
"pos": [
145,
149
]
} | {
"id": "C0027708",
"name": "nephroblastoma",
"pos": [
245,
259
]
} |
previous studies have found that both asc and mmpi panic-fear scale scores are related to the maintenance of the medical intractability of asthma . | subset_includes_concept | {
"id": "C3539025",
"name": "asc",
"pos": [
38,
41
]
} | {
"id": "C0449820",
"name": "scores",
"pos": [
68,
74
]
} |
in a multivariate analysis of ambulatory care utilization of a subsample of the 1970 national health interview survey ( nhis ) data the dependent variables representing utilization , acute conditions and chronic conditions were found to have discrete variable properties violating normality assumptions of standard regression analysis . | subset_includes_concept | {
"id": "C1513894",
"name": "national health interview survey",
"pos": [
85,
117
]
} | {
"id": "C1511726",
"name": "data",
"pos": [
127,
131
]
} |
among 34 lines including 18 types of human tumors , human specific plasma proteins were demonstrated in the plasma of nude mice transplanted with two lines of renal cell carcinoma , one adenocarcinoma of the colon , and one squamous cell carcinoma of the maxillary sinus . | subset_includes_concept | {
"id": "C2981607",
"name": "types",
"pos": [
28,
33
]
} | {
"id": "C0007134",
"name": "renal cell carcinoma",
"pos": [
159,
179
]
} |
among tumour types the neurogenic ones were most frequent at 50.8 % , followed by leukaemias ( 18.1 % ) sarcomas ( 12.3 % ) , malignant non-hodgkin lymphomas ( 7.3 % ) and mixed tumours ( 6.5 % ) . | subset_includes_concept | {
"id": "C2981607",
"name": "tumour types",
"pos": [
6,
18
]
} | {
"id": "C1261473",
"name": "sarcomas",
"pos": [
104,
112
]
} |
some apomorphine-induced effects ( stereotyped behavior , circling behavior , climbing behavior , and increased motor activity ) could be related to stimulation of one type of dopaminergic receptor , other effects ( hypothermia and decreased activity ) to the other type . | subset_includes_concept | {
"id": "C2698628",
"name": "related",
"pos": [
138,
145
]
} | {
"id": "C0205447",
"name": "one",
"pos": [
164,
167
]
} |
one can also speculate that this inflammatory response represents a normal response to an abnormal event , or is also abnormal in the sle patient . | subset_includes_concept | {
"id": "C3640251",
"name": "normal response",
"pos": [
68,
83
]
} | {
"id": "C0205161",
"name": "abnormal",
"pos": [
118,
126
]
} |
using 31p-mr spectroscopy spectra with good signal-to-noise ratio were obtained in five different types of tumours ( ewing 's sarcoma , osteosarcoma , malignant melanoma , metastases from a squamous cell carcinoma , parotid adenoma ) . | subset_includes_concept | {
"id": "C2981607",
"name": "types",
"pos": [
98,
103
]
} | {
"id": "C0029463",
"name": "osteosarcoma",
"pos": [
136,
148
]
} |
using 31p-mr spectroscopy spectra with good signal-to-noise ratio were obtained in five different types of tumours ( ewing 's sarcoma , osteosarcoma , malignant melanoma , metastases from a squamous cell carcinoma , parotid adenoma ) . | subset_includes_concept | {
"id": "C2981607",
"name": "types",
"pos": [
98,
103
]
} | {
"id": "C0025202",
"name": "malignant",
"pos": [
151,
160
]
} |
the 10-year disease-free survival for the distinct tumor types was 100 % for cushing 's disease , 82.3 % for patients with amenorrhea/galactorrhea , 79.6 % for non-functioning adenomas , 69.0 % for acromegaly , and 66.7 % for nelson 's syndrome . | subset_includes_concept | {
"id": "C2981607",
"name": "tumor types",
"pos": [
51,
62
]
} | {
"id": "C0001430",
"name": "adenomas",
"pos": [
176,
184
]
} |
there was no evidence that the patient 's gender or type of tumour affected their overall mental adjustment to cancer and the effect described in breast cancer may apply to all types of malignant disease . | subset_includes_concept | {
"id": "C2981607",
"name": "type",
"pos": [
52,
56
]
} | {
"id": "C0006826",
"name": "cancer",
"pos": [
153,
159
]
} |
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