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" patients are normally monitored through commonly available tests such as:
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" The prognosis of pulmonary arterial hypertension (WHO Group I) has an ""untreated"" median survival of 2–3 years from time of diagnosis, with the cause of death usually being right ventricular failure (cor pulmonale). A recent outcome study of those patients who had started treatment with bosentan (Tracleer) showed that 89% patients were alive at 2 years. With new therapies, survival rates are increasing. For 2,635 patients enrolled in The Registry to Evaluate Early and Long-term Pulmonary Arterial Hypertension Disease Management (REVEAL Registry) from March 2006 to December 2009, 1-, 3-, 5-, and 7-year survival rates were 85%, 68%, 57%, and 49%, respectively. For patients with idiopathic/familial PAH, survival rates were 91%, 74%, 65%, and 59%. Levels of mortality are very high in pregnant women with severe pulmonary arterial hypertension (WHO Group I). Pregnancy is sometimes described as contraindicated in these women.
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" The epidemiology of IPAH is about 125–150 deaths per year in the U.S., and worldwide the incidence is similar to the U.S. at 4 cases per million. However, in parts of Europe (France) indications are 6 cases per million of IPAH. Females have a higher incidence rate than males (2–9:1).
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" Other forms of PH are far more common. In systemic scleroderma, the incidence has been estimated to be 8 to 12% of all patients; in rheumatoid arthritis it is rare. However, in systemic lupus erythematosus it is 4 to 14%, and in sickle cell disease, it ranges from 20 to 40%. Up to 4% of people who suffer a pulmonary embolism go on to develop chronic thromboembolic disease including pulmonary hypertension. A small percentage of patients with COPD develop pulmonary hypertension with no other disease to explain the high pressure. On the other hand, obesity-hypoventilation syndrome is very commonly associated with right heart failure due to pulmonary hypertension.
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" For people that inherited the disease, gene therapy is being studied.
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"= = = Mark Quinn = = =
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" Mark David Quinn (born May 21, 1974) is a former Major League Baseball outfielder and right-handed batter who played for the Kansas City Royals and former coach for the Baltimore Orioles. Quinn was drafted in the 11th round of the 1995 Amateur Draft after playing two seasons for the Rice University Owls. He played for the Royals between 1999–2002. He retired for good in 2007 after spring training with the Yomiuri Giants.
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" In 1998, Quinn led the Texas League in batting average when he hit .349 for the Wichita Wranglers. He captured a second minor league batting crown the following year, posting a .360 average for the Omaha Golden Spikes of the Pacific Coast League.
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" On September 14, 1999 Quinn became just the third player in MLB history to hit two home runs in his major league debut, joining Bob Nieman (1951) and Bert Campaneris (1964). In Quinn became the Royals regular leftfielder. He hit .294 with 20 home runs, earning him the Sporting News American League Rookie Player of the Year and a spot on the 2000 Topps All-Star Rookie Team. Quinn split the season between right field, left field, and designated hitter. His production at the plate dropped to 17 homers and a .269 average. Quinn opened the 2002 season on the DL with one of the more bizarre sports injuries: a broken rib caused by ""kung-fu fighting"" with his brother in San Diego. By Quinn only appeared in 23 games for the Royals and hit just .237 in what would be his final year in the majors.
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" After the Royals released him during Spring Training of , Quinn played in the San Diego Padres, Tampa Bay Devil Rays, St. Louis Cardinals, and Chicago White Sox organizations, along with a stint for the Long Beach Armada of the independent Golden Baseball League.
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" In four seasons with the Royals, Quinn batted .282 with 45 home runs, 167 RBI, 153 runs, 72 doubles, five triples, and 17 stolen bases in 293 games.
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" Quinn's 45 career home runs surpassed fellow Royals alumnus Jamie Quirk's total of 43, giving him the second-most home runs all time for a player whose last name begins with a ""Q"". Outfielder Carlos Quentin has 154 career home runs as of the end of the 2014 season.
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" His penchant for free-swinging and refusing to take walks led to a fireworks display (normally reserved for home runs) over Kauffman Stadium in his final season when he drew a walk after a long drought.
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" Mark Quinn owns The Baseball School in Houston, Tx, and coaches the Houston Royals select teams.
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" On January 6, 2016 Quinn was hired to become the assistant hitting coach for the Baltimore Orioles.
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", or Retrosheet, or Pelota Binaria (Venezuelan Winter League)
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"= = = North/South Ministerial Council = = =
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" The North/South Ministerial Council (NSMC) (, Ulster-Scots: ) is a body established under the Good Friday Agreement to co-ordinate activity and exercise certain governmental powers across the whole island of Ireland.
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" The Council takes the form of meetings between ministers from both Republic of Ireland and Northern Ireland and is responsible for twelve policy areas. Six of these areas are the responsibility of corresponding North/South Implementation Bodies. The body is based in the city of Armagh in Northern Ireland.
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" The North/South Ministerial Council and the Northern Ireland Assembly are ""mutually inter-dependent"" institutions: one cannot exist without the other. When the Northern Ireland Assembly is suspended, responsibility for areas of co-operation fall to the British-Irish Intergovernmental Conference.
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" The Ministerial Council consists of representatives of both the Northern Ireland Executive and the Government of Ireland. The Ministerial Council may meet in either a plenary or, more commonly, sectoral format. In a plenary meeting a Northern Ireland delegation is led by the First Minister and deputy First Minister of Northern Ireland while the Republic's delegation is led by the Taoiseach and Tánaiste (prime minister and deputy prime minister).
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" A meeting in a sectoral format deals only with one particular policy area, and consists of the minister from Dublin with responsibility for the area under discussion, and two ministers from Northern Ireland (usually one unionist and one nationalist), including the minister with the relevant competence. The Council is supported by a standing joint secretariat, consisting of members of the civil services of both Northern Ireland and the Republic.
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" The Council also has occasional meetings in an ""institutional"" format to consider other business and technical matters, such as appointments to boards.
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" The Council is responsible for twelve ""areas for co-operation"". Six of these are in areas where co-operation must be agreed together but implemented separately in each jurisdiction. Six more are in areas where co-operation is agreed together and implemented through shared all-Ireland ""implementation bodies"".
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" Areas for co-operation where implementation is carried out separately:
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" The six all-Ireland implementation bodies are:
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" In addition to these bodies, Tourism Ireland, is a ""de facto"" seventh implementation body. Additional areas for co-operation may be added by agreement among the Council and with the endorsement of the Northern Ireland Assembly and Oireachtas.
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" Originally, a new jointly owned agency, Lights Agency, was intended to replace the Commissioners of Irish Lights, which is funded from the UK Department for Transport-managed General Lighthouse Fund to provide coastal aids to navigation throughout the island of Ireland. However, complexities arising from the transfer of functions have meant that this has had to be reconsidered.
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" Twenty-one plenary meetings were held between 1999 and 2015: one each year from 1999 to 2002, and 2007 to 2008; and on average two each year thereafter. Meetings alternate between north and south, usually in Armagh and Dublin. Sectoral meetings occur more frequently at various locations.
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" The level of co-operation differs across areas. For example, co-operation on tourism proceeded very rapidly (creating Tourism Ireland in 2000). On the other hand, there was initially little co-operation in the area of transport. At first because of resistance from the relevant minister in Northern Ireland and later because, after the restoration of the Council following suspension of the Northern Ireland Assembly, because the British and Irish governments had already done much of the work during a period of direct rule.
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" In 2007, the joint secretariat number 25 personnel, comprising 10 from Ireland and 15 from Northern Ireland. In 2010, the secretariat took up new, permanent office in Armagh. Budgets, staff numbers and headquarters for the six implementation bodies (including Tourism Ireland) in 2008 were as follows:
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"= = = List of northernmost settlements = = =
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" Some of the northernmost settlements in the world are:
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" This is a list of the northernmost cities and towns in the world.
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" Northernmost cities with more than 100,000 inhabitants.
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" Northernmost cities with more than 250,000 inhabitants.
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"= = = Barry Moore (baseball) = = =
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" Robert Barry Moore (born April 3, 1943 in Statesville, North Carolina) is a former Major League Baseball pitcher. The left-hander was signed by the Washington Senators as an amateur free agent before the 1962 season and played for the Senators (1965–1969), Cleveland Indians (1970) and Chicago White Sox (1970).
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" Moore made his major league debut in relief on May 29, 1965 against the Minnesota Twins. He entered the game in the top of the 9th with the Senators behind, 10-7, and gave up one unearned run in his one inning of work. Washington scored a run in the bottom of the inning, and the game ended, 11-8. He earned his first big league win on July 23, 1966 by pitching a three-hit complete game against the Kansas City Athletics in front of a home crowd of only 2,777. The score was 8-1.
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" His finest major league effort was against the Twins on April 30, 1967 (Game # 2). He pitched a one-hit complete game shutout at D.C. Stadium that day, walking only two batters. The Twins had such players as César Tovar, Rod Carew, Harmon Killebrew, Bob Allison, and Zoilo Versalles in the lineup, but Moore was almost untouchable. Tovar got the only Minnesota hit, a 6th-inning single, as the Senators won 3-0. This time there were 18,555 in attendance.
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" Moore did have a tendency to be wild, as he gave up 300 walks in just 599.2 innings pitched, for a BB/9IP of 4.50, much higher than the American League average at that time. Often, a pitcher who walks a lot of batters strikes out a lot, too, but that wasn't the case with Moore. With 278 strikeouts, his K/9IP was 4.17, which was lower than the American League average.
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" Career totals for 143 games played (140 as a pitcher) include a 26-37 record, 99 games started, 8 complete games, 1 shutout, 14 games finished, and 3 saves. He allowed 277 earned runs in his 599.2 innings, giving him a lifetime ERA of 4.16.