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Didactic Tools features five artists responding to the current explosion of instructional and educational culture, from YouTube tutorials and TEDx to the proliferation of data visualization, analytics, digital whistleblowing and new political movements.
The multidisciplinary ensemble bring together performance, visual art, sound and media works with biological science and architectural practice. Through collective research, sharing tools and conducting experiments in peer-to-peer education, the artists have drawn lines between the vast sub-cultures in which digital teaching and learning now thrive.
Didactic Tools presents five artists embracing the challenge of work with knowledge in art, each considering how the transference of the work’s ‘source code’ – its information, intention, meaning or provocation – might resonate with its evocative qualities.
This project has been convened by Perth-based company Hydra Poesis and features new work by artists:
- Kynan Tan (WA/NSW)
- Sam Fox (WA)
- Tarsh Bates (WA)
- Keg de Souza (NSW) and
- Jake Oorloff (Sri Lanka). | <urn:uuid:18f7743e-8424-41b5-a881-3a375b1bdf72> | CC-MAIN-2022-33 | https://www.fac.org.au/whats-on/post/didactic-tools/?pid=58 | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.911184 | 228 | 2.09375 | 2 |
"I am reaffirming that the United States government will not make concessions, such as paying ransom, to terrorist groups holding American hostages," President Obama said in a statement in June 2015.
A recent Wall Street Journal report is calling that policy into question after the U.S. reportedly delivered $400 million in cash to Iran at the same time American hostages were released.
In January, White House and U.S. State Department officials simultaneously announced the release of hostages, including Washington Post reporter Jason Rezaian, and a $1.7 billion settlement for a previous financial dispute dating back to before the Iranian Revolution.
The White House said the $400 million was representative of that settlement. However, it seemed Iranian defense officials inferred the cash was a ransom payment. And some members of Congress agree.
The report stated that because it's illegal for the U.S. to conduct monetary transactions with Iran in U.S. dollars, the cash consisted of euros, Swiss francs and other foreign currency stacked on wooden pallets.
Prior to the Wall Street Journal report, ransom claims were tossed around, but White House officials responded by saying the timing was purely coincidental. U.S. State Department Spokesman John Kirby said, "As we've made clear, the negotiations over the settlement of an outstanding claim at the Hague Tribunal were completely separate from the discussions about returning our American citizens home." | <urn:uuid:a1c56cdf-a359-420f-857f-b5696d6b6e18> | CC-MAIN-2022-33 | https://www.newsy.com/videos/white-house-insists-400-million-was-not-iranian-hostage-ransom/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.973798 | 284 | 1.742188 | 2 |
Women who get hot flashes have higher blood pressure than those who don’t, according to a new study led by Weill Cornell Medical College.
High blood pressure is a major risk factor for heart disease - the latter being responsible for half of all deaths among American women 50 and older.
“One-third of the women we studied reported having had hot flashes within the past two weeks. Among these women, systolic blood pressure was significantly higher - even after adjusting for whether they were pre-menopausal, menopausal or post-menopausal,” says Dr. Linda Gerber, the study’s senior author, professor of public health and medicine and director of the biostatistics and research methodology core at Weill Cornell Medical College. “Future research will help us better understand the mechanisms underlying this relationship and may help to identify potential interventions that would reduce the impact of hot flashes on blood pressure.”
While previous research has linked menopause to high blood pressure, the new Weill Cornell study, published in the March/April issue of Menopause: The Journal of the North American Menopause Society, may be the first to link hot flashes to high blood pressure.
Portable monitors recorded the blood pressure of 154 New York City women, aged 18 to 65 (mean age of 46), with no previous cardiovascular disease and either mild hypertension or normal blood pressure. Fifty-one women reported experiencing hot flashes. These women were found to have an age-adjusted mean systolic awake blood pressure of 141 and a mean systolic sleep blood pressure of 129 - compared to 132 and 119, respectively, for women not reporting hot flashes (P=0.004 and 0.007). The group differences for systolic blood pressure remained statistically significant after controlling for conventional hypertension risk factors, race/ethnicity, age and body mass index (BMI).
Hot flashes are typically experienced as a feeling of intense heat with sweating and rapid heartbeat, and usually last from two to 30 minutes on each occasion. The event may be repeated a few times each week or up to a dozen times a day. Hot flashes are thought to be caused by centrally increased activation of the sympathetic nervous system.
Co-authors include Dr. Joseph E. Schwartz of SUNY-Stony Brook (Stony Brook, NY) and Weill Cornell Medical College; Dr. Lynnette Leidy Sievert of the University of Massachusetts (Amherst); Katherine Warren, who was at Weill Cornell Medical College; and Dr. Thomas G. Pickering of NewYork-Presbyterian Hospital/Columbia University Medical Center and Columbia University College of Physicians and Surgeons.
For more information, patients may call (866) 697-6397.
Source: NewYork-Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College | <urn:uuid:39a829b1-b267-4dfe-b92d-a5e23c3316d9> | CC-MAIN-2022-33 | http://www.health.am/gyneco/more/hot-flashes-in-women-linked-to-high-blood-pressure/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573104.24/warc/CC-MAIN-20220817183340-20220817213340-00473.warc.gz | en | 0.926676 | 587 | 3.15625 | 3 |
Child Advocacy Center getting ready to open
Colorado’s 14th Judicial District will soon have a child advocacy center in Steamboat Springs, where children who are victims of abuse or neglect can participate in forensic interviews and get connected to resources.
The Brighter World Child Advocacy Center is a sister organization of Advocates of Routt County and will be housed next door to Advocates, but it is a partnership between Advocates, UCHealth Yampa Valley Medical Center and Court Appointed Special Advocates, or CASA, an organization that works with abused and neglected children in the court system from Routt, Moffat and Grand counties.
Currently, the 14th Judicial District is one of only four in the state that does not have a child advocacy center. The closest centers are in Glenwood Springs and Breckenridge. Planning for the new center began in March 2020.
“It’s long overdue, and I’m really excited at the prospect of it coming together here,” said District Attorney Matt Karzen. “Making these kids comfortable is a moral obligation if we’re going to make them talk about these things.”
When families and children walk into the center, they are first greeted by a large room with video games, a television and board games on one side, and stuffed animals and children’s books on the other. The room is meant to resemble a family room and feel like a welcoming atmosphere for both children and teenagers. Maria Paula Gonzales, the center’s family advocate, will greet children and families, assess their needs and connect them with resources.
“The idea is that when a family walks in, we want them to feel like they’re walking into a family room, so they’re immediately comforted,” said Advocates Executive Director Lisel Petis.
Children are then interviewed by Julia Luciano, a trained forensic interviewer. While Luciano is conducting the interview, law enforcement officers and representatives from the Routt County Department of Human Services are able to watch a live video recording of the interview from another room in the center.
If children need a forensic exam, the hospital has a professional to conduct the exam on site. By having all parties at the center at once, the process becomes easier for children, as having to retell a story and meet with multiple people in different locations can be traumatizing, Luciano said .
“An interview can bring up a lot for a kid,” Luciano said. “This is the place families can go to get whatever they need.”
Gonzales, who used to work as an interpreter at Integrated Community, said she once worked with a Spanish-speaking family who was navigating the court system as domestic violence survivors and remembered feeling frustrated at the extra language barriers the family had to deal with.
“I saw the big need we had in the community,” Gonzales said.
She was also serving on the Advocates board at the time and helped bring the Child Advocacy Center to fruition. Once the center was officially built, Gonzales was recruited to fill the family advocate position because of her previous experience with Advocates, as well as her language skills.
“My goal is to assist families through a process that’s not going to be easy for anyone and just make that process a little bit easier,” Gonzales said. “What I’m hoping is that the experience I have working at Integrated Community will help me be a good resource for people.”
Mark Fitzgerald, Advocates operations and development manager, said a Spanish-speaking advocate working in the center was important because Routt County has a large Spanish-speaking population, which is often underserved due to language barriers.
“We knew there was this community that we weren’t reaching and just being there for them and letting them know that we’re here has opened the door,” Fitzgerald said.
While the center will work directly with law enforcement, Karzen said having children be interviewed by a forensic interviewer rather than a police officer can be much more comforting for the child.
“How you engage with the victim on the front end is going to dictate so much moving forward,” Karzen said. “Doing it the right way builds reliability in the system.”
Advocates will be holding a free concert from 2 to 6 p.m. Friday at Little Toots Park at Yampa and 12th streets to raise awareness and collect donations for the center. The center will officially open Aug. 1.
To reach Alison Berg, call 970-871-4229 or email [email protected].
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Readers around Steamboat and Routt County make the Steamboat Pilot & Today’s work possible. Your financial contribution supports our efforts to deliver quality, locally relevant journalism.
Now more than ever, your support is critical to help us keep our community informed about the evolving coronavirus pandemic and the impact it is having locally. Every contribution, however large or small, will make a difference.
Each donation will be used exclusively for the development and creation of increased news coverage. | <urn:uuid:2ec4e171-8b71-4121-a347-8cb3e1f68f6e> | CC-MAIN-2022-33 | https://www.steamboatpilot.com/news/child-advocacy-center-getting-ready-to-open/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.9645 | 1,085 | 1.585938 | 2 |
You might think that buying an old house will save you some money. After all, the purchase price is much lower than the cost of a new house. An older home adds the convenience of being located closer to downtown areas, thus, reducing transportation costs. However, some hidden costs will surface as soon as you buy an old house reducing any financial gains you had foreseen. Below are some of the leading hidden expenses associated with purchasing old homes.
The roof is one of the common areas that usually require repairs in old houses. An old roof has issues such as missing shingles and moss. An excellent looking roof, on the other hand, is likely to have problems that are not visible from the ground. An inspection can discover issues such as the use of new shingles to cover old ones. The replacement is normally done incorrectly. Additionally, if these repairs were done more than once, they could result in damage to the entire home. Therefore, roof issues are a catalyst for added expenses.
The modern electrical requirements in homes today are very different from the designs that were used in older homes. Households today use more electricity than people did fifty years ago. Today you use computers, dishwashers, and televisions among other electrical appliances. Older homes use the knob and tube wiring which cannot support the level of power that is used in modern homes. If the house you are buying uses this type of tubing, companies will insist on replacing it, or they will recommend an electrician who can certify that the installation is in excellent condition. You’ll likely have to add a furnace installation to update your home and make it habitable. Whichever the solution, you will incur excess cost.
Many old homes do not have insulation because they were not built with energy efficiency in mind. Those that have insulation are no longer effective. Therefore, to get air conditioning in your new home, you will be required to update the insulation as well as the windows since they are often single-pane. These energy upgrades will cost you more money that you had not anticipated.
Asbestos was typically used in older buildings because it is a flame retardant. However, when the barbed fibers from asbestos are inhaled, they can lead to a deadly form of cancer. Despite the burn of asbestos use in houses, many old homes did not have it removed. Thus, you will need a home inspector to confirm if the old house you want to buy has asbestos and consider the costs of removal which can be very significant.
Buying an old home is exciting because it carries history. However, you should always be aware of what you are buying to avoid any unnecessary extra costs. | <urn:uuid:0e1659b8-c1a4-4546-acf1-b8f06dfb4b1a> | CC-MAIN-2022-33 | https://haznos.org/2019/4-hidden-expenses-of-buying-an-old-house/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.975913 | 554 | 1.921875 | 2 |
Members of Tampa Bay's congressional delegation have sent letters to the director of the Federal Emergency Management Agency to ask for aid for residents who have had their homes damaged by last week's flooding, even though the damage won't likely meet typical guidelines.
Instead of considering a statewide threshold of $25 million in damage for aid to be sent, Reps. David Jolly, Gus Bilirakis and Kathy Castor have asked FEMA to consider the regional threshold of $8 million, while also naming the weeks of flooding a single event.
Typically, aid is not doled out to areas that experience weeks of torrential downpour, while areas that are hit by hurricanes and tornadoes are more likely to get help.
Any Murray could be eligible for any aid that comes from Washington.
"(These weeks have been) hell," said Murray, who lives in the Bass Lake neighborhood of Pasco County. "The Salvation Army has given us food and showering and they have port-a-potties and hand wash stations."
She bought her house and moved in just a few months ago. Her ground floor is still filled with water.
"It fills back up at least a foot and a half overnight."
Rep. David Jolly says she, and hundreds of others, should not have to face the repairs on their own.
"The administrator of FEMA is a Floridian," said Jolly. "He has a lot of experience when it comes to natural disasters in Florida. I am confident that he is giving his closest attention to this matter."
Pasco's Emergency Operation Center is still at full staff of about fifty.
"Water continues to be on the move," said the county's director of emergency management, Annette Doying.
Her staff is working to coordinate transportation, communications and essential services.
They have maps of each home that might need federal help, along with roads that will need to be repaired by the state.
"We are positioning social services to start to work through those ongoing needs."
About 50 homes have been destroyed and 400 have been damaged.
Murray is looking forward to when she doesn't have to rely on a Salvation Army truck outside her home for the basics.
"We have kids and animals," she said. "It's a bad situation right now."
If approved, FEMA aid could be used to fix houses and businesses.
Officials will tour Pasco County on Thursday morning to catalog the damage. | <urn:uuid:a113b16c-ac15-40d2-b7d4-11cd0a0a770c> | CC-MAIN-2022-33 | https://www.fox13news.com/news/push-to-make-pasco-flooding-eligible-for-federal-aid | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882572304.13/warc/CC-MAIN-20220816120802-20220816150802-00473.warc.gz | en | 0.977538 | 497 | 1.53125 | 2 |
Minimum wages have become widely recognised as a vital tool for reducing poverty and restoring economic stability around the world. A mandatory national minimum wage has numerous effects on the economy. It contributes to raising wage levels and closing wage gaps, making it a key step toward achieving inclusive growth. The extent to which the minimum wage set is both fair and economically valid will determine its success. The implementation of the minimum wage on the ground has the potential to considerably assist wage earners, particularly those in the unorganised segment of the market.
Minimum wages are the absolute minimum, not the highest or even the current average salary. In India, the goal of minimum wage legislation is to establish a basic income that adequately protects the most vulnerable workers. As a result, states set minimum salaries in order to offer a monetary value that is similar to the workers’ and their families’ minimal consumption demands. And because this monetary value ignores the workers’ age and years of experience, minimum wages are both entry level and exit level salaries for all intents and purposes. Simply put, minimum wage is the lowest salary that a business may give to their employees, as set by law.
The Indian economy is characterised by dualism, or the existence of a centrally organised sector alongside a decentralised sector with a huge population of self-employed people. The phrase ‘labour’ is contained in the Constitution’s ‘concurrent list,’ which allows both the federal and state governments to enact labour legislation. State government’s police labour regulations for the majority of workers in the informal sector, while the federal government regulates contractors and casual workers in enterprises. Wage levels and structures in the informal sector are influenced by all labour legislation enacted by the central government, whether directly or indirectly.
The International Labour Organization (ILO) defines minimum wage as the declared level of remuneration that cannot be reduced further, either by mutual agreement or compulsion by the employer, for labour performed during a defined period by wage earners. Various countries, including ILO members, have established minimum wages based on their labour markets. Basic pay, annual bonuses, tips, in-kind benefits, productivity and performance pay; allowances and premiums for non-standard work hours or dangerous labour are all possible components of minimum wage.
Minimum wage systems can only be effective if they are clear about which components of the wage are to be counted in the minimum, how much payment-in-kind is permissible, and whether the computation is for an hourly/weekly rate, among other things. A three-factor analysis can be used to assess the effectiveness of minimum wages:
- Coverage: Is the scheme open to all wage earners, including women, youth, and migrants? Its implementation in both commercial and public sectors must be consistent.
- Level: The pay must be set at a level that meets the workers’ and their families’ fundamental needs while also taking into account the most important economic issues.
- Compliance: The theoretical aspect alone is insufficient to ensure that the minimum wage system achieves its intended goal. Employers must effectively comply with minimum wage requirements.
The history of minimum wage legislation may be traced back to 1894 in New Zealand, when the first national minimum wage regulations were implemented. The Industrial Conciliation and Arbitration Act was enacted. It made salary negotiations with labour unions subject to mandatory arbitration. The Harvester judgement was made in Australia in 1907. It created a “living wage” for a man, his wife, and their two children in order for them to “live in economical comfort.” A significant development in this regard was the inclusion of a reference to minimum wages in the Federal Constitution of Mexico adopted in 1917. Article 123, VI, of that instrument, states that “The minimum wage to be received by a worker shall be that which is considered sufficient, according to the conditions of each region, to satisfy the normal needs of his living, education and honest pleasures, considering him as head of the family”. This constitutional provision, which was the first of its type anywhere to recognise the government’s obligation for providing minimal living standards, led to the establishment of the National Minimum Wage Board in 1933, which set general minimum pay for all workers across the country. The International Labor Organization (ILO) passed the Minimum Wage Fixing Machinery Convention in 1928, which had a global impact.
Closer to home, the British did not want to repeat these worldwide developments for Indian labourers because it was not in their economic interests. However, Article 43 of the Indian Constitution recognises the state’s responsibility to build an economic order in which every citizen finds work and earns a “fair wage.” In 1943, the Indian Labour Conference and the Standing Labour Committee formed a Labor Investigation Committee to look into issues such as working conditions and minimum salaries. The Standing Labour Committee proposed specific legislation dedicated solely to the problem of minimum wages in 1946. A tripartite body known as the Fair Pay Committee was formed with the goal of establishing a “fair wages” policy. The Committee was made up of employers, employees, and government officials. It established three separate salary levels:
- Living Wage
- Fair Wage
- Minimum Wage
Indian legislation on minimum wage
Minimum wage was established to assist people to not only support themselves, but also to meet other essential requirements such as education, health care, shelter, and other necessities. The Minimum Wages Act of 1948 was enacted as a result of this. The Act spelled out the steps for determining and establishing minimum wages in specific businesses. Wages were to be set by appropriate governments (at both the central and state levels) for various scheduled employments (based on skilled and unskilled labour, agricultural and nonagricultural employments, and minimum wages determined for various industries across various Indian states) under their jurisdiction for a set period of time. Once the minimum wage rates have been established according to the legal system, it is the employer’s responsibility to pay those wages regardless of the employer’s ability to pay.
The National Floor Level Commission proposed a National Floor Level Minimum Wage in 1991, with the goal of reducing wage disparities between minimum and average wage levels across the country. It’s worth noting that the National Floor Level Minimum Wage isn’t a legal requirement. This means that the state is not obligated to raise the minimum wage in accordance with this body’s recommendations, which instead serve as a persuasive tool for raising minimum wages. The Minimum Wages Act, as well as other wage-related legislation such as the Payment of Wages Act, 1936; the Minimum Wages Act, 1948; the Payment of Bonus Act, 1965; and the Equal Remuneration Act, 1976, were repealed in August 2019.
The Code of Wages, 2019
On August 8, the President signed the 2019 Wage Code, which had previously been passed by Parliament. The Code strives to govern pay and bonuses for all workers employed by any industry, trade, business, or factory, and supersede four laws: the Payment of Wages Act, 1936; the Minimum Wages Act, 1948; the Payment of Bonus Act, 1965; and the Equal Remuneration Act, 1976. Santosh Kumar Gangwar, the then-Minister of Law and Justice, established the Wages Code in 2019 in an attempt to fix legal gaps in prior legislation that had been utilised to exploit workers. This was done in order to ensure consistency in the application of legislative regulations controlling wage payment. Because only by making laws universal can timely payment of wages to workers and employees be guaranteed without any discrepancies. It applies to both organised and unorganised industries.
The Code recognises that the goal of setting the floor wage is to ensure “basic living standards” for workers, and the draught guidelines reflect criteria established by the Supreme Court in a landmark decision in 1992, as well as recommendations made by the 15th Indian Labour Conference. The net calorific needs of a working-class family (defined as the earning worker, spouse, and two children or the equivalent of three adult consumption units) are set at 2,700 calories per day per consumption unit, their annual clothing requirements are set at 66 metres per family, house rent expenses are assumed to be 10% of food and clothing expenditure, and expenses for children’s education, medical needs, recreation, and contingencies are all assumed to be 10% of food and clothing expenditure.
Major Highlights of the Code
Definition of wages: The Code specifies a single standard definition of the term wages for the purposes of minimum wages, wage payment, and bonus payment. Previously, the meaning varied according to the country’s diverse labour laws. Now there are three elements to the unified definition: inclusion, exclusion, and restrictions that limit the number of exclusions.
Minimum Wages: The Code also codifies the concept of a “floor wage,” a long-awaited goal. It is the minimum wage set by the federal government after taking into account the geographic necessities for a basic quality of living. No state government can pay less than this. Furthermore, a government with a minimum wage that is higher than the authorised floor wage is prohibited from lowering it. Employees must be paid at least twice as much for overtime as they are paid for regular work. To keep up with market changes, this salary level will be revised every five years at the most.
Payment of wages: The Code specifically allows for the determination of the wage period, whether daily, weekly, or monthly. Now, the employer must pay the wages for each wage period according to the time period specified. The settlement period for the preceding month’s work, for example, is on the 7th day of each month. Wages must reach workers within two working days if the employer resigns or is dismissed from the position for whatever reason. The time limit for filing a claim for minimum wage or equal remuneration used to be anything from 6 months to 2 years, but it has now been extended to 3 years.
What issues challenge the implementation of policy?
Implementation: In India, enforcing the minimum wage is challenging due to the large informal sector. According to a research, in 2009-2010, around 35% of total wage workers did not receive any benefit from this scheme. The intention of combining labour rules into one Code was to promote compliance, but how this shift of more and more workers being paid the minimum wage can be enforced remains a question.
Consumption: Because food is a basic human requirement, calorie intake is one of the most important elements in determining the minimum wage. The energy need is 2700 kilocalories, according to the Code. A working-class family traditionally consists of the wage earner, his or her spouse, and two children, and their consumption units are calculated as follows:
1 unit for the wage worker (often a male), 0.8 unit for the spouse (typically a woman), and 0.6 unit for each child, for a total of 3 consumption units. Many experts believe that, aside from being biased, this estimate may not be sufficient for developing youngsters. They propose dividing 1+1 + 0.75 + 0.75 into 3.5 consumption units, which is the current calorie need of a typical family. There’s also the issue of non-food consumption, which is given far less weight than it should be in light of current trends.
Representation: The Code also proposes the formation of a technical committee, whose members will be chosen from the three groups of stakeholders: government, employers, and employees. However, there is no element of productivity in the portrayal. The National Productivity Council should have been included because salaries are inextricably tied to productivity, just as they are to social justice.
Dynamic concept: The concept of minimum wage is dynamic because it is based on various elements that change throughout time. Inflation, which reduces purchasing power, is the most dreadful of them all. Real wages must be changed on a regular basis to guarantee that they remain at a level that allows for a particular amount of spending. Although there are mechanisms for adjusting Dearness Allowance, the fundamental component is not susceptible to such modification, making the minimum wage inefficient in terms of changing purchasing habits over time.
Work hours: The Code indicated that the total hours of work in a day were 9, rather than the customary 8 hours. This is strange in a time when developed countries are attempting to minimise working hours. Furthermore, the maximum number of hours worked, including rest periods, is 12. If any of the businesses use it to reduce shifts from three to two, this might be hazardous to employees. The exploitative nature of the Indian labour market is nothing new, and spoon-feeding a provision that plays out in the employer’s advantage at the expense of misuse could be a step backward.
The 2019 Wage Code has spurred controversy and discussion about the minimum wage. As previously stated, the umbrella legislation tries to eliminate the multi-jurisdictional model of wage fixing by establishing a floor rate. When used correctly, it has the potential to benefit all of the primary stakeholders. Despite the fact that labour activists have expressed several grounds of concern, there cannot be a direct comparison between India and other affluent countries. In developing nations like India, there is a scarcity of research on the impact of minimum wage on employment levels. This is a significant barrier to the government determining a wage level that is equitable to all wage earners. The monopolistic nature of the Indian economy’s domestic and construction sectors further obstructs the minimum wage’s goal.
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This year the Missing and Murdered Inquiry into Indigenous Women and Girls concluded, but Aboriginal women continue to go missing and fall victim to homicide at a significantly higher rate than the Canadian average. Beyond the inquiry, what else needs to be done to make this country safer for Indigenous women?
Rachel Blaney, NDP:
After the Conservatives refused to address the tragedy of missing and murdered Indigenous women for almost a decade, the Liberal government finally launched a long overdue inquiry – but then set it up with a limited mandate, and failed to adequately care for the families who courageously shared their stories. The Inquiry’s finding of a genocide against Indigenous women in Canada demands action from all Canadians. I will work in partnership with Indigenous women, the families of the missing and murdered, and communities to implement the Inquiry’s Calls for Justice and the calls to action brought forward by communities.
Peter Shwarzhoff, Liberal:
Liberals are committed to ending this ongoing tragedy. We accept the findings of the report and have started to develop an action plan, as recommended. It will be developed in partnership with First Nations and Metis governments as well as with the families of the missing and murdered Indigenous women and girls.
We have started on the path to reconciliation and although we know we have a very long way to go, Perry Bellegarde has said we have already made more progress than any other government in the last 50 years. We are committed to closing the gap.
Mark de Bruijn, Green:
Greens will re-introduce legislation to enshrine UNDRIP and will implement the recommendations from the Truth and Reconciliation Commission. Greens will legislate housing as a fundamental human right, and will prioritize high quality, safe and affordable housing. A Green national transportation strategy, including services to rural and remote communities, will ensure access to reliable, affordable transportation. Under the leadership of Indigenous organizations, Greens support the formal inclusion of traditional healing within mental wellness programs. The Green budget allocates $10 billion for free college and university tuition and removes the 2% cap on increases in education funding for Indigenous students.
Shelley Downey, Conservative:
I have picked up female hitchhikers while traveling around the north island. Why? To help them get to their destination safely. I have even rented rooms for a night so that they were safe until they could continue their travels the next day. Access to reliable transportation would certainly keep all women from harm. In addition, the expansion of cell service into remote areas and communities provides the ability to call for help. | <urn:uuid:03799a94-8606-481d-a028-8ba546d890d4> | CC-MAIN-2022-33 | https://hashilthsa.com/news/2019-10-10/what-needs-be-done-indigenous-women-beyond-inquiry-north-island-powell-river | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573540.20/warc/CC-MAIN-20220819005802-20220819035802-00473.warc.gz | en | 0.956655 | 521 | 2.34375 | 2 |
Evaluate and assess these factors thoroughly before deciding the type of stove that is best for your kitchen. Here’s a comparative analysis:
Gas Vs Electric Stove: Price
Electric ovens cost more than gas ovens, forthright. Yet, you ought to likewise think about the working expenses of both the oven types when choosing. Since in many pieces of the country power rates are significantly high, the working expenses of gas ovens are similarly less expensive – this implies, going in for gas ovens works out to be more affordable over the long haul.
Gas Vs Electric Stove: Durability
With regards to strength and energy productivity, you ought to consider which of these oven types will actually want to help you for a more drawn out period. In this unique situation, gas ovens are clear victors. It has been seen that gas ovens endure 2 to 5 years more than electric ones.
Gas Vs Electric Stove: Energy Efficiency
Study and look at the energy efficiencies of the two sorts of ovens. According to information, best ceramic hob cleaner are 40% energy-productive, though electric ovens are 74% energy-proficient. This implies that 74% of the energy gets moved to the food when utilizing electric ovens contrasted with just 40% when utilizing gas ovens. Subsequently, anticipate that the food should prepare quicker with electric cooktops.
Gas Vs Electric Stove: Temperature Control
Electric ovens can be initiated with a basic press of a catch. Notwithstanding, in a gas oven, the fire warms the foundation of the dish quicker contrasted with the electric oven. Likewise, with the distinctive handle conditions, it turns out to be not difficult to control the temperature or the warmth in a gas oven. Allow us just to say that the gas cooktops are quicker to react to temperature changes versus the electric ones.
Gas Vs Electric Stove: Safety
On the off chance that you have a developing family, with children and matured individuals around, it is ideal to proceed with the electric cooktop. Why? Since it is more secure! There are no dangers of a gas spill. The odds of fire-related occurrences have been observed to be more common with the gas ovens.
Gas Vs Electric Stove: Maintenance
With regards to cleaning the ovens, the electric oven is an aid for the cook. Freshest models of electric ovens accompany smooth ceramic tops. You basically need a sodden material to clean. Consistently cleaning it off utilizing a delicate fabric will keep it glimmering and looking like new for quite a while.
The decision between the electric and the gas oven is totally founded on your solace remainder. There is no correct decision here. Just gauge the advantages and disadvantages of the two ovens and match it with your need to return home the right one. | <urn:uuid:06491592-2480-49dd-bec1-bf6aea4a4343> | CC-MAIN-2022-33 | https://homesnetwork.org/gas-vs-electric-stove-which-is-the-better-option/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573540.20/warc/CC-MAIN-20220819005802-20220819035802-00473.warc.gz | en | 0.934217 | 579 | 1.75 | 2 |
It is not uncommon for employees to face hazards at work. Those who work in fast food may find themselves slipping and falling due to grease on the floor. Those who work in the automotive repair industry may find themselves slipping on automotive fluids. Even those who work in the relative safety of an office may slip and fall over loose tiles or carpeting.
No matter what your occupation or where you work, you may be at risk of a slip and fall. Should the worst happen and you become injured due to such an accident, there are a few things you need to know.
Your Employer’s Insurance
Almost all employers are required to carry worker’s comp insurance by the state in which they operate.
This insurance covers any losses that an employee may suffer due to an injury that was incurred while on the job. This insurance ensures that if you do slip and fall at work and incur medical bills and/or suffer lost wages because of the accident, you are financially protected from the resulting fallout of the accident.
There are criteria you must meet in order to qualify for worker’s comp insurance due to a slip and fall at work:
- You must have been on the job when the injury occurred. If you were on a lunch break or staying around off the clock when the accident happened, your likelihood of winning a slip and fall case drastically decreases.
- You need to ensure that you were following all company policy in regards to behavior when the accident occurred.
Some employers, for example, may choose to drug test an employee after such an accident. If you fail the drug test, not only do you risk losing the claim but you also risk losing employment.
Violating your employer’s policies during an accident can render your claim invalid, and it is in the insurance company’s best interests to investigate such claims to the best of their ability.
Determining Who Is At Fault
In all slip and fall cases, including those that happen while on the job, determining fault can be crucial to the outcome of your case. This is especially true if you do not live in a “no fault” worker’s comp state. If you are at fault for the accident when it occurs, chances are that you will receive no compensation from your employer or his or her insurance provider.
If, on the other hand, your employer was the one at fault, then you may be entitled to damages including the cost of medical care and damages for lost wages and pain and suffering.
If the slip and fall occurred while you were under the influence of drugs or alcohol, then you will not be entitled to compensation for the accident. The same is true if the accident occurred as a result of our intent to injure yourself or injure someone else.
If, on the other hand, the employer was truly at fault due to negligence and forcing you to work in hazardous conditions, the compensation you can seek may be much greater than that of a typical worker’s comp injury.
If the employer was beyond a doubt at fault, the case may escalate from a worker’s comp case to a personal injury case. Because of this, it is usually best to consult with an attorney prior to filing a claim with your employer and/or your employer’s insurance provider.
How an Attorney Can Help If You Fell at Work
If you fell at work, a personal injury attorney can help you with your claim. A personal injury attorney will help you make sure you gather and submit as much physical evidence as possible. A Personal injury attorney can help you make sure that all of you can get compensated for any lost wages, medical bills and loss of earnings.
If you fell at work, a personal injury attorney will be able to negotiate with the insurance claims adjuster on your behalf to make sure that you are fairly compensated. When you are in the process of hiring a personal injury attorney, make sure that you hire an attorney that has experience in slip and fall claims.
Filing a Claim against Your Employer
Filing a claim against your employer, whether it be a worker’s comp claim or a personal injury claim, can be a tricky and uncomfortable situation. The fear of retaliation may be enough to deter you from even filing a claim. This is why it may be in your best interests to consult with an attorney prior to filing a claim.
Not only will your attorney know whether your claim is best suited as a worker’s comp claim or a personal injury claim, but he or she will also ensure that your legal rights are protected and that the claim is filed properly. | <urn:uuid:7eb5536d-f417-4e39-9968-265dec0f4c1c> | CC-MAIN-2022-33 | https://www.personalinjury-law.com/slip-fall/work | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.962725 | 939 | 1.6875 | 2 |
|“||A GDI field base is under attack. They have fended off one attack but will not survive another. Move to the base, repair the structures and then launch a strike force to destroy the Nod base in the area. Destroy all Nod units and structures.
- Mission briefing
With Brigadier General Sheppard dealing with the fallout from the Białystok scandal, GDI lost much of its funding, pending the results of a UN investigation. Because of this loss of funding, the GDI had initiated tactical isolation procedures which prevented field commanders such as James Solomon from communicating with the central GDI command. With some difficulty the commander was able to receive a directive speaking in generic terms about a GDI base in his area.
Should Solomon had previously engaged in Poland, either by reinforcing Białystok or retrieving stolen equipment near Gdansk, Nod forces would then have conquered the entirety of Germany. This left small pockets of GDI resistance in Hanover and Dresden, which the commander soon discovered and acted to reinforce.
GDI forces in Ukraine had fought a desperate battle against the invading Nod forces and Solomon was determined to aid them. While Kiev had already fallen, GDI forces still held out in the extreme east of the country. But some pockets of resistance still existed in the west of the country. Solomon determined that the GDI base being referred to must be such a pocket, a base somewhere in the country, specifically the one near Ivano-Frankivsk.
GDI forces, at one location under the personal command of Solomon arrived in the vicinity of the bases. They had arrived just on time, the area was fully of GDI forces. Making headway to the bases they found them nearly deserted and badly damaged, after repelling the last Nod assaults which had severely damaged the bases the GDI forces were gone, presumably dead or defected.
Arriving before Nod forces could level the bases, the GDI commander repaired the bases and restored them to full operation. Having done so they were able to assemble an army sufficient to eliminate the nearby Nod bases and regain control of the country.
With GDI bases in either countries secured, the GDI turned their attention to the Czech Republic and Austria. In a garbled transmission to Solomon, Carter orders a commando raid on a Nod base near Ostrava.
- The mission maps for northern Germany (SCG05WA) and western Ukraine (SCG05EA) are nearly identical, albeit some minor differences to the Tiberium field and tree placements on the map.
- Sheppard's press conference (prelude cinematic)
- Besieged GDI base (mission start cinematic)
- An eagle grabbing a scorpion (mission accomplished cinematic)
- Remastered mission 5WA playthrough (THE ZOD)
- Remastered mission 5WB playthrough (THE ZOD)
- Remastered mission 5EA playthrough (THE ZOD)
- Remastered mission 5EB playthrough (THE ZOD)
- Westwood Studios, Command & Conquer. GDI mission 5: "repair gdi base". | <urn:uuid:c4fa5c8d-02c7-445b-81dc-a9e12494e52d> | CC-MAIN-2022-33 | https://cnc.fandom.com/wiki/Restoring_Power | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573540.20/warc/CC-MAIN-20220819005802-20220819035802-00473.warc.gz | en | 0.951737 | 676 | 1.875 | 2 |
Pursuant to the Media Act, the duties and powers related to the surveillance of media governance are divided between the Media Council and the Office of the NMHH. Within that context, the Media Council relies on the Office of NMHH to monitor the annual reports of the media service providers using the frequencies, verify compliance of the content of the concluded regulatory contracts and the media service fees to be paid by the operators, assess annual advertising spendings in the Hungarian media market, and evaluate the changes on the advertising market. The objective of the Media Council is to protect the rights and interests of viewers and listeners, i.e. to ensure that Hungarian media consumers can enjoy programmes compliant with the law. To this end, the Council urges television and radio stations to provide services in compliance with the Media Act, which offers a clear framework to providers.
As part of the surveillance, the NMHH and the Media Council carry out the following, among other functions:
verify compliance with programming quota obligations (a certain percentage of broadcasters’ airtime must be dedicated to European and/or Hungarian music – for radio stations, such provisions apply to music that is either Hungarian or no more than 5 years old);
assess the compliance of commercial announcements i.e. advertisements (this includes, among others, the provision that the combined duration of advertisements in linear commercial media services may not exceed 12 minutes (6 minutes for public service broadcasting) per programming hour, no advertisement may violate human dignity, minors may not be directly invited to purchase a product);
check compliance with regulations on the broadcasting of content harmful to minors (this obviously implies obligations concerning the age rating of programmes, as well as the fact that the resulting rating signs must be featured in both online and printed programme guides);
conduct research and analyses (monitoring, among others, the share of crime reports in news programmes, assessing the latest television adverts, product placements other harmful content that may appear in reality shows);
make decisions in matters of balanced coverage (media services are required to cover subjects that are significant and of general interest in a comprehensive, factual, up-to-date, objective and balanced fashion);
ensure that closed captioning is provided for audiences with a hearing impediment (as for public broadcasters and media service provider with sifnificant influence, all announcements, political advertisements, news programmes, as well as any other features presenting political affairs or people with a disability must be made available with subtitles for the hard of hearing) and
continuously assess whether service providers comply with their reporting obligations.
Society’s control over public service broadcasters is guaranteed by the Public Service Board, which also monitors how public service orientation is manifested. The NMHH is in charge of coordinating the appointment procedure of members of the Board. | <urn:uuid:000ef8ca-4728-4656-978c-51e86c5cdd1c> | CC-MAIN-2022-33 | https://english.nmhh.hu/stakeholders/media-supervision | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882572161.46/warc/CC-MAIN-20220815054743-20220815084743-00473.warc.gz | en | 0.937848 | 567 | 1.84375 | 2 |
can tortoises get infections from inside a normal house?
recently my 4 year old hermanns tortoise has been getting very restless and since its winter, he cant really be outside so i have started letting him wander round the house from around 5pm to 10pm. there are also two dogs around as well, but they will definately not attack him, so i was wondering if he can catch an infection from them or anything else?
also can you think of a reason why he is suddenly so restless? thanks! | <urn:uuid:c77fcb75-ccb4-41f8-af0d-1003fbaec0d7> | CC-MAIN-2022-33 | http://www.totallytortoise.com/can-tortoises-get-infections-from-inside-a-normal-house.html | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573540.20/warc/CC-MAIN-20220819005802-20220819035802-00473.warc.gz | en | 0.982561 | 119 | 1.601563 | 2 |
Explore Ireland's Ancient East
Your 4 Day itinerary
Explore our local attractions and plan how to spend your days with us using our itinerary, as advised by our local experts!
The History of Kilkenny
Situated on the River Nore, Kilkenny (often referred to as Marble City due to its black marble quarries), is an old Norman settlement which was given the status of a city in 1609 by King James I of England. Between 1642 and 1649 Kilkenny was also the capital of Confederate Ireland between 1642 and 1649. Currently, Kilkenny is home to the seat of the Roman Catholic Bishop of Ossory and the Church of Ireland Bishop of Cashel and Ossory.
Family Attractions in Kilkenny
Kilkenny is a very family friendly place. It’s compact city centre is easy on little legs, and when you need a pit stop, there are plenty of cafés and child friendly restaurants where you can kick back and relax. We know you won’t want to spend all your time in the hotel, so here are some great ideas to ensure you have a fun filled holiday, with lots of happy memories!
Standing guard over the city on the banks of the River Nore sits Kilkenny Castle. Home of the powerful Butler family for nearly 6 centuries, the castle was extensively added to and improved upon with series of fortifications and lavish accommodation to meet the changing needs of the times and is an imposing complex.
One of the most popular tourist attractions in Ireland, Kilkenny Castle can get busy during summer months so we recommend visiting earlier or later in the day to avoid the peak periods and take time to savour the incredible history and architecture of this amazing site.
SHOPPING IN KILKENNY
Kilkenny city centre offers an original and eclectic mix of designer labels, high street names and independent shops. Wander the web of shopping streets to browse an amazing array of boutiques, vintage stores, artisan craft shops and fashion favourites. Whether you’re here on a shopping break in Kilkenny or just passing the time during your stay, you’ll be spoilt for choice.
THE WATERSHED KILKENNY
The Watershed is one of Ireland’s best sports and leisure facilities, conveniently located just 800m from The Hoban Hotel Kilkenny and our guests can avail of discounted entry prices! Featuring a swimming pool, childrens fun pool and full leisure centre.
IRELAND’S ANCIENT EAST
The Hoban Hotel is a perfect base for your travels across Ireland’s ancient east. Explore everything Kilkenny and Ireland’s Ancient East has to offer from the comfort of the Hoban Hotel and its ideal location.
GOLFING IN KILKENNY
Some of Ireland’s best golf clubs are on your doorstep. Take advantage of your time at The Hoban Hotel Kilkenny and get in a few rounds at our nearby golf clubs.
Ballykeefe Distillery is The Birthplace of Irish Whiskey. It is located among the beautiful Irish countryside of the medieval capital, Kilkenny City. At Ballykeefe Distillery they produce a range of
Award-Winning spirits in an eco-friendly environment.
The first written account of distilling whiskey in Ireland comes from Kilkenny in 1324. It was written in the Red Book of Ossory. The word “Whiskey” is an Anglicisation of the Gaelic phrase “uisce beatha” which means “water of life”.
Take the tour of Ballykeefe and discover the roots of Irish Whiskey. Tours are available from the months of April to October and can be booked through their website. | <urn:uuid:bc94380e-32bd-4656-a498-e702bac28a48> | CC-MAIN-2022-33 | https://www.hobanhotelkilkenny.com/discover | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.943256 | 811 | 2.03125 | 2 |
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Bullard, Claude L (Len) writes:
> Any system can be hacked and security bugs show up in all of them.
> The issue of the monoculture is real enough, but not a catastrophe.
> One could make the claim that securing one system is all that is
> needed, but the facts say otherwise.
As John mentioned, you need to be careful about using the word
"hacked", because it has different meanings for different people.
For many developers, "easily hacked" means "easily extended and
maintained". If you use the term "cracked" in your postings, there's
Microsoft is going through a painful, decade-long transition from
standalone and single-user to networked and multi-user -- the
transition means abandoning many principles that were originally dear
to them (and brought them great success in the standalone days), like
*always* favouring convenience over security. Some of the
optimizations they made, like putting so much in the kernel (including
a lot of GUI code), will also keep coming back and biting them for a
while, since every bit of code inside the kernel is a potential
Posix operating systems also have vulnerabilities, of course, but
because they were designed to be multiuser and networked from the
start, their fundamental design is more sound: as I mentioned earlier,
Posix systems tend to have relatively thin kernels and do most of
their work in user space, so they can be hardened to a large extent
simply by making sure that the user-space programs do not have root
permissions. Not everyone does that, but at least it *can* be done.
So, what about XML and its related specifications? I'm afraid that
we're more like Microsoft than like the Posix systems: we're starting
with glaring security holes like external DTD subsets and external
entity references for the sake of convenience, and we will have to fix
those holes later if XML ever becomes popular on the Web. With no
fixed limit on element names, number of attributes, nesting depth,
etc., XML applications can also easily fall prey to buffer-overflow
attacks or denial-of-service attacks if they are not very carefully
written. I believe that the old SGML declarations were very annoying,
but it might not hurt to set some arbitrary, very high limits for the
next version of XML, such as
Maximum name length: 4096 characters
Maximum attributes: 1024
Maximum element nesting depth: 65536
etc. Every robust XML application has to do that anyway to avoid
either buffer-overlow or DOS attacks (by memory exhaustion), so it
would be a good idea to start spreading a good, standard practice now.
All the best, | <urn:uuid:0b8054ab-0ca8-4aec-b73a-c0be3f3be93a> | CC-MAIN-2022-33 | http://lists.xml.org/archives/xml-dev/200310/msg00073.html | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.946052 | 610 | 2.390625 | 2 |
Commercial heating and air conditioning systems serve a vital role in facilitating normal business operations and maintaining a comfortable indoor environment. Over one-third of a company’s total monthly power consumption can be attributed to the operation of the HVAC system. Facilities administrators and business owners recognize the importance of choosing a contractor with a strong background in every phase of the commercial air conditioning and heating industry.
Commercial System Design
Light commercial systems usually range from 5-15 tons in total output capacity. Unlike residential applications, the heating and cooling load can fluctuate significantly depending on the nature of the business. Manufacturing and IT facilities usually generate a substantial amount of process heat. Retail and food service companies have varying occupancy rates and periodic disruptions in the external air barrier.
To ensure that the load requirements are satisfied during the most extreme conditions, it is vital that the HVAC contractor assembles a comprehensive set of load calculations for the entire building and each partitioned area.
At Gilman Heating, Cooling & Plumbing, our designers engineer every system according to ACCA Manual J standards. These complex calculations account for a variety of energy consumption factors including:
- Projected occupancy rate
- Insulation value of walls and ceiling
- Process generated heat
- Perimeter tightness
- Windows and doors
- Duct Leakage
- Local climate history
Once the total load has been established, our designers will match the capacity of the equipment to meet the most extreme anticipated demand. This will ensure that the system operates efficiently while providing an elevated level of indoor comfort.
In new construction or retrofit applications, a commercial heating and AC contractor must adhere to the construction schedule and coordinate directly with the general contractor. During the rough-in phase of the job, our field mechanics install the air distribution system according to ASHRAE 90.1 and UL 181 standards. After the equipment is set, the system is charged with refrigerant, and we run several tests to verify it is performing to the manufacturer’s specifications. Economizers and make-up air units are adjusted for optimal performance, and the diffusers are air balanced.
In the business environment, every commercial air conditioning and heating malfunction is an urgent situation. When the indoor environment is uncomfortable, productivity can suffer and sales opportunities may be lost. For industries with rigid temperature and humidity specifications, an unexpected equipment failure can be catastrophic.
We understand the importance of answering every service inquiry promptly and dispatching a technician in a timely manner. We allocate significant resources to service, so we can address multiple jobs simultaneously.
On the jobsite, our factory trained and NATE certified technicians use advanced tools and equipment to locate the cause of the failure and rapidly restore the system to full functionality.
To help avoid the potential for an unexpected breakdown, we recommend a commercial heating and air conditioning maintenance agreement. Preventive maintenance can improve system efficiency and help identify small problems before they affect equipment performance.
Complete Commercial HVAC Services
Gilman Heating, Cooling & Plumbing has served the business community in Virginia since 1917. We provide a wide selection of commercial HVAC services designed to improve indoor comfort, lower utility costs and extend the lifecycle of the equipment. | <urn:uuid:9b7907e1-6324-4287-9f80-b25f950a7390> | CC-MAIN-2022-33 | https://www.gilmanheatingandcooling.com/services/commercial-hvac | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.908987 | 656 | 1.921875 | 2 |
Monitor respiratory status and lung sounds. Pulmonary function tests may be assessed periodically during and for several mo after a transfer from systemic to inhalation corticosteroids.
Assess patients changing from systemic to inhalation corticosteroids for signs of adrenal insufficiency (anorexia, nausea, weakness, fatigue, hypotension, hypoglycemia) during initial therapy and periods of stress. If these signs appear, notify physician or other health care professional immediately; condition may be life-threatening.
Monitor for withdrawal symptoms (joint or muscular pain, lassitude, depression) during withdrawal from oral corticosteroids.
Monitor growth rate in children receiving chronic therapy; use lowest possible dose.
Lab Test Considerations:
Periodic adrenal function tests may be ordered to assess degree of hypothalamic-pituitary-adrenal (HPA) axis suppression in chronic therapy. Children and patients using higher than recommended doses are at highest risk for HPA suppression.
May cause increased serum and urine glucose concentrations if significant absorption occurs.
After desired clinical effect is obtained, decrease dose to lowest amount required to control symptoms. Gradually decrease dose every 2–4 wk as long as desired effect is maintained. If symptoms return, dose may briefly return to starting dose.
Inhaln Allow at least 1 min between inhalations of aerosol medication.
Advise patient to take medication as directed. Take missed doses as soon as remembered unless almost time for next dose. Advise patient not to discontinue medication without consulting health care professional; gradual decrease is required.
Advise patients using inhalation corticosteroids and bronchodilator to use bronchodilator first and to allow 5 min to elapse before administering the corticosteroid, unless otherwise directed by health care professional.
Advise patient that inhalation corticosteroids should not be used to treat an acute asthma attack but should be continued even if other inhalation agents are used.
Patients using inhalation corticosteroids to control asthma may require systemic corticosteroids for acute attacks. Advise patient to use regular peak flow monitoring to determine respiratory status.
Caution patient to avoid smoking, known allergens, and other respiratory irritants.
Advise patient to notify health care professional if sore throat or mouth occurs.
Instruct patient whose systemic corticosteroids have been recently reduced or withdrawn to carry a warning card indicating the need for supplemental systemic corticosteroids in the event of stress or severe asthma attack unresponsive to bronchodilators.
Metered-Dose Inhaler: Instruct patient in the proper use of the metered-dose inhaler. Canister must be primed prior to first use. Do this by releasing 2 actuations into air away from face. If not used for more than 3 days, reprime with 2 actuations. Shake inhaler well. Exhale completely and then close lips firmly around mouthpiece. While breathing in deeply and slowly, press down on canister and hold breath for as long as possible to ensure deep instillation of medication. Remove inhaler from mouth and breath out gently. Allow 1–2 min between inhalations. Rinse mouth with water or mouthwash after each use to minimize fungal infections, dry mouth, and hoarseness. Wash inhalation assembly at least daily in warm running water (see medication administration techniques).
Management of the symptoms of chronic asthma.
Improvement in asthma symptoms.
triamcinolone (inhalation) is a sample topic from the Davis's Drug Guide.
Pediatrics Central™ is an all-in-one application that puts valuable medical information, via your mobile device or the web, in the hands of clinicians treating infants, children, and adolescents. Complete Product Information. | <urn:uuid:63353405-865e-49f5-bd07-ede88397e7ac> | CC-MAIN-2022-33 | https://peds.unboundmedicine.com/pedscentral/pview/Davis-Drug-Guide/109858/all/triamcinolone%20%20inhalation%20 | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573104.24/warc/CC-MAIN-20220817183340-20220817213340-00473.warc.gz | en | 0.898332 | 796 | 2.21875 | 2 |
Advanced Vehicle Technology Future Predicted at SEMA 2019
LAS VEGAS, Nov. 6, 2019—The CEO of the Center for Automotive Research dived into how the U.S. is viewing and reacting to advanced vehicle technology, and what that could mean for the automotive industry.
“The weight of cars we think have gone down but no, no, not at all, they’ve stayed about the same because of all the technology we’re adding today,” says Carla Bailo, CEO of the Center for Automotive Research.
Yet, with the addition of new technology, customer preference for electric vehicles is the lowest globally in the U.S. About 71 percent say they are going to buy an internal combustion engine.
And, about 65 percent of people today are turning off ADAS features because it’s delivering false positives. So, the technology being added to cars, to help drivers drive safer, is actually being turned off by the consumer.
“Let’s be clear on this, automated driving assistance helps you drive safer but it does not drive for you,” Bailo says.
The consumer is becoming the creator, says Mike McCoy, CEO and co-founder of Hackrod, a digital industrial startup combining the cultures of computer hackers with hot-rod enthusiasts.
McCoy debuted Hackrod's goal to make the consumer into a digital designer of advanced cars, all through the process of gaming, AI and virtual reality. McCoy and his team are working on a platform in which gamers can digitally design a vehicle, which would then be engineered with AI and 3-D printed.
So, picture a future of advanced vehicles, designed by the consumer and micro-manufactured. | <urn:uuid:78a61f32-46cb-40db-9baf-e708fbf229c2> | CC-MAIN-2022-33 | https://www.fenderbender.com/articles/13965-advanced-vehicle-technology-future-predicted-at-sema-2019 | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.956269 | 360 | 2.375 | 2 |
If air pollution doesn’t kill you, it could leave you blind, alarming new study finds
A new study has reinforced the link between the increased risk of irreversible sight loss and prolonged exposure to certain kinds of air pollution, in worrying news for heavily industrialized nations around the world.
The research, published Tuesday in the British Journal of Ophthalmology, used data from more than 115,000 participants who all reported no eye problems at the beginning of the study period in 2006.
While previous research has drawn a link between air pollution and glaucoma, as well as cataracts, this latest paper examined the link between pollution particles suspended in the air and the onset of age-related macular degeneration (AMD).
The high blood flow to and from the eyes is suspected of making the organs much more vulnerable to damage inflicted by tiny particles in the air, with a growing body of research and evidence suggesting air pollution is greatly diminishing humanity’s vision over time.Also on rt.com Scientists on verge of creating ‘artificial vision’ which could restore partial sight in the blind via BRAIN IMPLANTS
Indeed, air pollution is the leading cause of blindness in the over-50 demographic in the industrialized world, with some estimates predicting up to 300 million people will be affected by AMD by 2040.
In this latest study, researchers collated traffic pollution, nitrous oxide levels, and small-particulate matter data to produce an annual average air pollution level to which the participants were exposed in their homes.
They then underwent a formal eye examination 14 years later, on conclusion of the study, at which point some 1,286 of them were diagnosed with AMD.
The researchers found an eight percent higher risk of contracting AMD in those with prolonged exposure to air pollution.
“Overall, our findings suggest that ambient air pollution, especially fine [particulate matter] or those of combustion-related particles, may affect AMD risk,” the authors said.
“Our findings add to the growing evidence of the damaging effects of ambient air pollution, even in the setting of relative low exposure.”
The World Health Organization estimates air pollution is directly linked to roughly seven million deaths annually. Now, a growing body of research indicates that those who are not killed by exposure to high levels of air pollution may face an increased risk of being blinded by it.
However, Tuesday’s study was observational and therefore did not establish a causal link between air pollution and AMD, merely a correlation of the two, so more research is needed to definitively prove causality.Also on rt.com Korean scientists may have discovered ‘elixir of youth’ that ‘erases wrinkles’ and could even reverse brain and muscle decline
Think your friends would be interested? Share this story! | <urn:uuid:96959c0b-7d35-419c-9100-540ca904264d> | CC-MAIN-2022-33 | https://www.rt.com/news/513665-air-pollution-irreversible-sight-loss/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573104.24/warc/CC-MAIN-20220817183340-20220817213340-00473.warc.gz | en | 0.946228 | 578 | 2.875 | 3 |
Delaware Injury Attorneys Serving Clients Injured in Trucking Accidents Caused by Driver Fatigue
Experienced injury lawyers representing clients in truck accident lawsuits
Truck drivers who drive when they are drowsy put themselves and those with whom they share the road in great peril. Lack of adequate sleep leads to fatigue, which dulls the driver's reflexes and slows down response time when they are behind the wheel. Drowsy truck drivers are a tremendous threat to highway safety, which is why the Federal Motor Carrier Safety Administration (FMCSA) recently overhauled their Hours of Service (HOS rules) for commercial truck drivers.
At the law firm of Silverman, McDonald & Friedman, we know how devastating it can be to survive a truck accident with serious injuries. We know how to investigate the truck accident, find out who is at fault and then pursue compensation on our clients’ behalf. We do not rest until we get justice for our clients.
Understanding the problem
In a post on the U.S. Department of Transportation's blog about truck driver fatigue, Anthony Foxx, Secretary of Transportation said, ". . . our rules must protect against those drivers and trucking companies who are tempted to push the limits and put our families and loved ones at risk. Nearly 4,000 people die in large truck crashes each year and driver fatigue is a leading factor. Tragically, the truck drivers themselves sometimes die driving tired."
Changing the law, however, does not always change driver behavior. Truck driver work very hard and under the extreme pressure of tight deadlines. Drivers push themselves hard to meet those rigorous schedules because they are not getting paid to rest.
Truck driver fatigue causes accidents
When a driver is extremely tired, their exhaustion makes it impossible for them to gauge their own level of fatigue and discern when they are just too tired to drive. An exhausted truck driver can nod off at the wheel, and if they happen to be travelling at highway speeds, the now out of control truck can cause an accident putting the driver's life and those with whom he or she shares the road in grave danger. A driver does not even have to fall asleep to become a danger on the highway. Their slowed reaction time can cause them to not respond in time, or overcorrect when they see that they have begun to veer off course.
Gathering the evidence of drowsy driving as the cause of a truck accident
After an accident during the course of the investigation, there will be several theories in play about what might have caused the crash. Drowsy driving might be just one of the contributing factors under consideration. Investigators can examine the driver's logbook, they can take statements from the driver and any witnesses, and they can look at any GPS data that might be available. Large, commercial trucks often have "black boxes" that record the vehicle's speed, braking and steering that occurred right before the accident happened. When there has been no evidence of braking, or swerving to avoid the crash, it is often an indication that the driver had nodded off and did not see the collision coming.
Driving in violation of the HOS rules is breaking the law. When a driver ends up causing an accident and it can be proven that they were operating the truck in violation of the HOS guidelines their commercial license will be in jeopardy. The truck driver and the trucking company that employs them may be held liable for any injuries and property damage that occur in the accident caused by their drowsy driving.
The Delaware truck accident attorneys at the law firm of Silverman, McDonald & Friedman are here to protect your interests when you have been injured in an accident caused by a drowsy truck driver. If you have lost a loved one in a truck accident, our compassionate legal team will make sure to get compensation for your losses. We are here to help.
Contact our trusted truck accident attorneys today to schedule a free consultation
The legal team at Silverman, McDonald & Friedman is proud to represent those who have been injured in a truck accident. We investigate your accident and hold the responsible party liable for your injuries. You may schedule your initial free consultation with one of our Delaware auto accident attorneys today when you call us at 302-888-2900 or fill out our contact form. We have offices in Wilmington, Seaford and Newark from which we serve clients throughout Delaware. | <urn:uuid:ccbd4ed6-280f-4327-9771-f19f1c20cf91> | CC-MAIN-2022-33 | https://www.smflegal.com/practice-areas/truck-accidents/driver-fatigue/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.958136 | 890 | 1.578125 | 2 |
Four top tips for managing your money in 2017
Shopping around for interest rates, a better mortgage deal and your energy tariff could save a bundle
The new year is almost upon us and with it the inevitable resolutions.
Alongside your promises to eat less, move more and learn a foreign language, the chances are you want to manage your finances better – those are the most popular resolutions after all. So, here are four ways to improve your finances in 2017.
1. Get the best interest rate on your savings
The new year is a great time to take a look at your savings accounts and see if you could boost your returns by moving to a better account. Interest rates may be pitiful but the good news is experts think they could start to move up in 2017.
“With inflation moving towards the Bank of England’s 2% target quicker than expected, the only way is up for interest rates in 2017,” says Nick Dixon, investment director at Aegon, in the Express.
If interest rates do start to rise in 2017 you don’t want to be tied into a lengthy fixed-rate bond that means you miss out. Luckily, the interest rate difference between long-term bonds and short-term is minimal at the moment.
Atom Bank is paying 1.4% on its one-year bond. Alternatively, if you have less than £2,500 to save then Nationwide is paying five per cent on its FlexDirect current account, but you will have to pay in at least £1,000 a month.
2. Remortgage while rates are low
The good news with low interest rate is that mortgage rates are amazingly low at the moment. Rates are starting to slowly tick up with the best offers – such as HSBC’s 0.99% two-year fix – disappearing from the market.
But, if you haven’t remortgaged for a couple of years you could still save yourself a fortune with deals on offer for as little as 1.17%.
Someone with a £200,000 25-year mortgage switching from a rate of four per cent to 1.17% would cut £285 off their monthly repayments and save themselves £6,855 over two years.
3. Check your energy deal
Several energy firms have announced they are freezing their prices over the winter, but this means come the spring your energy bills will rise. Avoid the problem by shopping around for a good fixed rate deal now.
Grab your latest energy bill and spend a couple of minutes on a comparison website to see how much you can save. The regulator's price comparison table suggests that the difference between the worst standard tariff and best fixed rate in the market is over £300.
4. Move your debts
Did you build up some credit card debt in 2016? Now’s the time to get on top of repaying it. Consolidate it onto one interest-free balance transfer card and you can repay it over a number of years without any interest increasing the debt.
The longest deal available is Halifax’s 41-month balance transfer card but it comes with a hefty 3.18% balance transfer fee. If you don’t need that long to clear your debt try Barclaycard’s Platinum 24 month interest free card that is has no fee. | <urn:uuid:553779c5-37a3-4b23-80cb-134532a3edd1> | CC-MAIN-2022-33 | https://www.theweek.co.uk/80078/four-top-tips-for-managing-your-money-in-2017 | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573104.24/warc/CC-MAIN-20220817183340-20220817213340-00473.warc.gz | en | 0.956925 | 684 | 1.820313 | 2 |
CYCLING hero Stephen Roche joined thousands of families in Kildare on a get-fit challenge to raise money for cancer research throughout Leinster counties.
The 1987 Tour de France winner kicked off the Loop of Leinster charity cycle at St Laurences GAA club, Narraghmore, Co Kildare.
The legendary cyclist organised the event in aid of the National Breast Cancer Research Institute the local community complex.
supervised A cycle sportive is an organised and supervised group cycle on a pre-arranged route.
Participation in cycling, and in particular cycle sportives, has enjoyed massive increases in numbers over the past five years.
The Leinster Loop event consisted of four distinct routes, the Leinster Loop - a challenging 140 km cycle through south Kildare, Laois, Kilkenny and Carlow; the Barrow Challenge - a testing 90 km cycle through Kildare, Laois and Carlow; the Cill Dara Cruise - a 50 km cycle and the Roche Ramble - a 12 km leisure cycle through south Kildare and open to individuals and families.
Meanwhile, hundreds of families made the most of the sunshine pockets at Malahide Castle at the Wonderfest.
The weekend event included live music performances, theatre, circus workshops, dance classes and plenty of food offerings.
The festival was created with parents and children in mind.
Alcohol consumption at the two-day event was strictly limited to the "Parent's Tea-Party" area.
The organisers provided camping in a deluxe area designed for families to enjoy time together, with full facilities on site. | <urn:uuid:934a5736-6c83-40ae-8957-dfbe93362130> | CC-MAIN-2022-33 | https://www.independent.ie/regionals/herald/news/families-get-on-their-bikes-for-roche-30515143.html | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573540.20/warc/CC-MAIN-20220819005802-20220819035802-00473.warc.gz | en | 0.915167 | 343 | 1.523438 | 2 |
Decentralization is a typical buzz word in the cryptocurrency ecosystem, and 0x is capitalizing on the concept by building a system that can be used for decentralized trading. This permits patrons and sellers to be linked immediately- there is no must belief a centralized trade to keep a dealer’s funds secure. The ZRX coin could be swapped simply with the help of a local digital trade in the Atomic Wallet.
0x is an ethereum-based decentralized change meant for trading belongings and cryptocurrencies using good contracts on the 0x platform. The 0x platform was founded in 2016 by Will Warren and Amir Bandeali with the intention of providing a normal protocol on the ethereum blockchain that facilitates the change of any ethereum token. 0x is a protocol that allows for decentralized trade 0x coin of tokens and property issued on the Ethereum blockchain. Developers can use 0x to create their very own functions for cryptocurrency trade with a wide range of functions, for example, the ability to conduct over-the-counter trading of tokens issued on the Ethereum blockchain. Token 0x is used makers and takurami to switch commissions to release.
0x allows the peer-to-peer trade of Ethereum-primarily based tokens and is often referred to as a decentralized exchange . The 0x platform supplies a means of exchanging quite a lot of tokenized assets corresponding 0x coin to shares, gold, actual estate and online game items, looking for to advertise interoperability between decentralized applications . 0x’s personal ethereum token is used to pay buying and selling fees to relayers.
At the time of writing, the whole market cap of the coin is over $150M USD in ZRX . There are also concerns that its enterprise model may not be sustainable. As cryptocurrencies grew to become well-liked final yr, exchanges made money hand over fist by amassing fees to facilitate trades between patrons and sellers. For example, Coinbase booked revenues of $1 billion in 2017 while China-primarily based Binance claims to have already made earnings of $200 million this quarter. The main supply of cash for both exchanges is charges from cryptocurrency trades.
The 0x project often turns into the one cryptocurrency that grows in relation to BTC. Its technology combines two strategies – State channels and Automated Market Marker – that have already been advised to beat these issues. State channels take transactions offline, thereby lowering https://beaxy.com/buy-sell/zrx-btc/ costs that are incurred if the transactions take place on ethereum’s network. AMMs introduce a third celebration to facilitate trades if the price of a cryptoasset reaches a certain threshold.
Comments and evaluation reflect the views of various external and inner analysts at any given time and are topic to alter at any time. Moreover, they cannot represent a commitment or guarantee on the part of PrimeXBT. It is specified that the past efficiency of a monetary product doesn’t prejudge in any means their future efficiency.
Consequently, as the quantity of orders increases on the trade, the prices of operating the change additionally balloons. Second, the method has fragmented users among quite a few cryptocurrency exchanges.
The ZRX tokens are also used to implement a decentralized administration of the 0x protocol replace mechanism, which permits for the substitute and improvement of the underlying good contracts. In 2017, a growth team led by Amir Bandeali and Will Warren introduced the unique 0x protocol for the decentralized change of ERC-20 and ERC-721 tokens. Their major thought was to create a secure blockchain network for launching decentralized apps and over-the-counter cryptocurrency buying and selling with minimal charges. Will Warren and Amir Bandeali co-based 0x in 2016 with the intention of providing a standard protocol on the Ethereum blockchain that permits any Ethereum token to be traded.
Market Wrap: Bitcoin Falls To $Eleven 1k; Ethereum Miners At Record Fee Percentage
- The distribution of customers amongst these exchanges has resulted in a corresponding fragmentation of liquidity.
- Gas is the amount of ether, ethereum’s cryptocurrency, required for each transaction.
- Consequently, as the amount of orders will increase on the exchange, the costs of operating the trade also balloons.
- Second, the strategy has fragmented users among numerous cryptocurrency exchanges.
- Linux is an open source operating system that can be downloaded free of charge.
- Within the context of cryptocurrency exchanges, because of this each purchase or sell transaction would cost a specified variety of gas tokens.
How much will XRP be in 2030?
XRP Price 2021: Smartereum noted that even conservative experts were suggesting that XRP could reach up to $1,000 a coin, in just a few years after 2019. XRP Price 2030: Smartereum’s feature reported projections that Ripple’s value could go up to $200-$300 by 2030.
With this protocol, buyers can use decentralized change via good contracts. The 0x platform claims that each one assets will be their own tokens sooner or later.
Uses Of The Ox Protocol
ZRX token homeowners can affect the blockchain’s governance — giving them the authority, proportional to their holdings, to supply input as to how the protocol should be developed over time. The platform can be used for multiple improvement duties like crypto exchange, information storage, prediction market, and numerous https://www.beaxy.com/ other use instances. The ox buying and selling market cap was fast to develop and reached a mark of over 1 billion dollars in January 2018. The primary goal of the protocol is to end the epoch ofcentralized exchangesby creating new tasks with their very own decentralized financial system.
It supports 300+ ERC20-based mostly tokens and other properly-known cryptocurrencies like Binance Coin , Litecoin , TRON and plenty https://www.binance.com/ of extra. 0x is a permissionless protocol based on the Ethereum sensible contracts.
Chinese Exchanges Struggle With Withdrawals As Users Turn To Defi
The 0x project was based in October 2017 by an expert and impressive team. It goals to create a protocol for the p2p change of any ERC-20 tokens in an open and decentralized environment https://www.investing.com/. All operations in the 0x Protocol setting are performed by way of Ethereum good contracts.
Is Zrx A Good Investment 2020?
Who owns the most bitcoin?
The mysterious creator of Bitcoin, widely known as Satoshi Nakamoto, remains the major holder of bitcoins. The number of bitcoins that Nakamoto owns today is estimated at around 1.1 million, based on the early mining that he did.
The trade of hundreds or even hundreds of tokens is only attainable via a secure platform. The 0x coin can be both saved and exchanged in Atomic Wallet, a safe decentralized crypto wallet for not only traditional property like Bitcoin , Ethereum , Ripple , but additionally 0x coin for the opposite 500+ tokens. Critics have already begun stating vital flaws with 0x’s approach. For starters, they say that the function of its token ZRW is unclear. But ether, ethereum’s native cryptocurrency, can be used for a similar purpose.
Can ethereum reach 100k?
As per an analyst on TradingView, Ethereum might reach 320 USD by the end of 2020, and believes it to be a realistic target for the cryptocurrency. He believes that Ethereum may reach $100,000 in another 5 years or so, and will eventually replace gold with crypto. | <urn:uuid:ebfcffc9-94cd-4391-ad10-9c978e66d5fc> | CC-MAIN-2022-33 | http://mjwaresusa.com/beginner-s-guide-to-buying-and-selling/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573540.20/warc/CC-MAIN-20220819005802-20220819035802-00473.warc.gz | en | 0.926308 | 1,554 | 1.898438 | 2 |
|Bronze statute of Dame Margot Fonteyn|
Photograph by Ian Yarham,
Creative Commons Attribution Share-alike licence 2.0
Peggy Hookham was born this day in Reigate exactly 96 years ago. She is of course better known as Dame Margot Fonteyn de Arias, prima ballerina assoluta and probably one pf the greatest dancers of all time. I won't attempt a biography. There are plenty around as well as her own autobiography. For those who want to research her life and career the Wikipedia article provides a good starting point.
I shall confine myself to some personal memories. Although I saw her on television many times as I was growing up I did not see her on stage until I went to university. This was in the late 1960s and early 1970s when she was entering her fifties. One of the roles that I saw her dance was Juliet in Macmillan's Romeo and Juliet from which a remarkable film was made. You can still see on YouTube. I saw her in most of the other great classical roles as I was a Young Friend of Covent Garden and practically lived at the House in the Christmas, Easter and first part of the Summer vacations between 1969 and 1972.
My last memory of Fonteyn was not on the stage but in the Great Hall of Lincoln's Inn. She had been invited to dine with the benchers on Grand Day. This is an occasion when prominent individuals in public life visit the Inn. Usually the benchers and their guests enter and leave the hall in silence. After their name is read out they are greeted with a bow which they usually reciprocate. But when Dame Margot left the Hall there was an explosion of applause as though she had danced Odette-Odile. Her smile will remain with me to my dying day. | <urn:uuid:68bcd8ee-bea0-46f9-a330-915891a63532> | CC-MAIN-2022-33 | https://jelterps.blogspot.com/2015/05/margot-fonreyn.html | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.987071 | 384 | 1.59375 | 2 |
When can I start Play Therapy for my child and who should I do it from?
Play therapy is a safe non-invasive therapy method that can easily be tailored according to each child"s needs and requirements. Thus, it can be started whenever a child is ready for it.
Most children on the autism spectrum already consult an occupational therapist; depending on the type of therapy suggested by the therapist, parents also get a better idea of when to start this type of therapy. However, since it is simple and does not have any side effects or complications, it can typically be started even without consultation. | <urn:uuid:308ee874-1e4d-4f07-9029-2809261c3a9a> | CC-MAIN-2022-33 | https://www.autismconnect.com/standard-treatments/complimentary/play-therapy/when-can-i-start-play-therapy-for-my-child-and-who-should-i-do-it-from | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.963475 | 122 | 2.015625 | 2 |
Hypnotherapy is a form of alternative therapy that can help deal with various disorders. It involves the use of specific techniques like guided visualisation, suggestion, regression, relaxation, etc. to reach deeper into the subconscious aspects of yourself.
According to hypnotherapy, if you are dealing with a situation where you respond in an unhealthy manner, it’s because of a similar situation in the past where you learned to respond in an unhealthy way.
When it comes to dealing with various types of disorders, hypnotherapy can help you identify what really causes the unhealthy pattern/behaviour and how you can resolve it.
Let’s explore the different types of disorders that hypnotherapy can help with.
5 Disorders that Hypnotherapy Helps With
1. Eating Disorders
Eating disorders like bulimia, anorexia nervosa, binge eating, etc. are on the rise with new beauty trends dictating how one is supposed to look. Adding to that, treatment for eating disorders is often very difficult and painful and there is always a chance of relapse.
While it may be unconventional, hypnotherapy provides a way to deal with these eating disorders. Using certain regression techniques, a licensed hypnotherapist can help you understand the core reason behind this issue. Moreover, with the help of relaxation and suggestion techniques, they’ll help you access your subconscious to identify your “trigger event”, which is the event that triggered the eating disorder.
Once this has been done, the hypnotherapist works with you to change the way you feel about yourself, about the situation and helps you deal with any cognitive distortions as well. There are a lot of good options for eating disorder hypnotherapy in the UK that you can consider if you want help dealing with this issue.
2. Post-Traumatic Stress Disorder
Post-traumatic stress disorder (PTSD) is usually the result of a severely traumatic event that has critically endangered, injured or threatened an individual. Symptoms of PTSD can include flashbacks, nightmares, insomnia, headaches or other physical symptoms, hypervigilance, etc.
Hypnotherapy for post-traumatic stress disorder can involve the use of specific visualisation techniques as well as specific hypnosis to help with the triggering event. It involves controlling the flashbacks you may have about the event by dis-associating yourself from them.
Solution focused hypnotherapy can also be used to help you develop a positive mind-set about the future. With the help of these techniques, you can deal with the effects of traumatic events and lead a happier and more positive life.
3. Anxiety Disorder
You may have heard plenty about anxiety disorders, which have become more apparent as people try to keep up with the stressful modern life.
Anxiety disorder is essentially a psychological disorder which is related to fear, panic, nervousness and worrying. While every one of us face anxieties in life, those who suffer from anxiety disorders find it difficult to control their worries and may end up indulging in unhealthy behaviours and habits to cope.
Hypnotherapy for anxiety disorders mainly focuses on resolving these anxieties and replacing unhealthy coping behaviours with healthy ones. In a hypnotherapy session, you will be put in a state of relaxation by your hypnotherapist, who will then use suggestions to help you resolve some of your worries. These techniques will also help deal with symptoms like stomach aches, headaches, nausea, etc. that are a result of anxiety.
Depression is a state wherein you are constantly in a low mood, to an extent where it starts affecting your daily life. Depression can be mild or extremely severe and can have harmful effects on both your mental and physical health.
Some other symptoms of depression include lack of interest in hobbies or activities, low energy, feeling tired, difficulty concentrating, sleeping too much or too little, etc.
While there are many psychotherapies that can help, hypnotherapy is also an option that can help you overcome depression. Using techniques like relaxation and suggestion, hypnotherapy guides you in identifying the root cause of depression and can help you slowly build a positive mindset. These techniques also help with other symptoms like sleep problems and having a lack of energy and interest in activities.
5. Sleep Disorder
A lot of people battle with sleep disorders, however, it may not be something they actively seek help for. Some examples of sleep disorders include insomnia, snoring or sleep apnea, sleep paralysis, etc. The effects of sleep disorders can be harmful if they are not properly dealt with.
From having a lack of energy to having severe health issues, sleep disorders can cause a lot of damage.
Hypnotherapy can prove to be useful when it comes to dealing with sleep disorders. Your hypnotherapist will first help you identify the cause of your disorder, for example, alcohol use or other disorders like depression and anxiety.
Once the core reason has been identified, the hypnotherapist works on resolving these issues with the help of techniques like suggestion, guided imagery or even regression. Once the issue is resolved, it becomes gradually easy for you to fall asleep. You may also be asked to use a guided sleep hypnosis tape to help you relax and fall asleep.
To Sum Up
Hypnotherapy can possibly be a solution to a lot of problems, including various types of disorders. While it is good practice to seek professional psychotherapeutic help, hypnotherapy can prove to be helpful in achieving progress faster. | <urn:uuid:fccc7c4e-555f-4e12-9f3d-80bcd62a15fc> | CC-MAIN-2022-33 | https://www.newstoday.co.uk/2022/07/5-types-of-disorders-that-hypnotherapy-helps-with/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.939667 | 1,127 | 2.359375 | 2 |
Thinking About Exploring Solar Energy? Read These Tips Today!
It is imperative to educate yourself on the topic before getting started so you can reap all its benefits properly. Read on for great solar energy.
The power you get will be determined by how many solar panels as well as the number of solar panels installed. You should be using math to help you find out the number of panels you will need. You could actually save money by purchasing a few high performance panels instead of efficient ones.
Start out small when starting with solar energy. You should not have any problem finding these lights at a store or mass market retailer. They are very easy to install as any other garden light.
To ensure that you're getting the most out of your panels, get installations that have technologies that don't directly rely on our sun's schedule. This is especially useful if you use home power at night.
Direct sunlight and a certain temperature are not always necessary.Some people will solar power generation on the worst looking days.
You can save a lot of money with solar panels if you are interested in long-term investments. Solar panels represent an important financial investment and may tale a while before your equipment is paid off. You need to make sure your financial situation is stable before you invest in solar energy only if you're settling down.
A panel system is a great option if you can afford it.This sort of system tracks the sun throughout the day. It will cost you more to install this kind of system, but you should start to generate a profit in a few years.
Photovoltaic panels are going to work best in areas with at least 5 hours of uninterrupted sunlight. Solar water heating can lower the cost of keeping a pool that is heated.
Solar energy greatly reduces harm to the most popular forms of energy due to the amount of money that can be saved by using it as well as the positive impacts that it brings to the environment. Now is the perfect time to consider solar energy.
You need to know exactly how much power you need in order to choose the right system to power your life. This information is crucial when choosing the right size solar energy system. Check your bills to see when you use the most energy.
These devices contain temperature sensors which can send the fans into operation at certain temperatures. This can help reduce energy necessary to cool your home by removing excess heat. As an additional incentive, being solar powered, it will not add to your power bill.
Bigger is not always better when considering solar panels.You should consider each of this before making your decision.
Pay close attention to weather when you initially begin considering a solar panels. Solar panels are a good option if there are five hours of direct sunlight a day in your area. You may want to look into other green energy options if your area is cloudy a lot or very snowy in the winter.
Change solar panel angles during the seasons, this would mean four times a year. The amount and direction of sunlight changes when the seasons change. If you move the panels, you stand a good chance of optimizing the energy that you can capture, getting the most of your investment.
If you are interested in a solar panel vendor, check on its financial standing first. You want to do business with someone that is likely be in existence for many more years. This will ensure your warranty so that you can get any necessary parts later on.
You must take more than cost into consideration when selecting your solar panels to buy. Solar panels have different wattage, wattage, manufacturer, warranty, performance and material quality. That means you must research every option thoroughly. Get the best solar panels that fit in your pocketbook.
Remember that you can both save and earn money while using solar energy system. If you purchase a solar panel system, you should see a quick return on your investment.
Remember to take any additional influences into consideration when calculating your solar panels to output. The listed expected output for most solar panels is calculated using ideal situations. Any obstruction from trees or from a cloudy day will also decrease the sunlight your panels actually receive.
It is crucial that you keep solar panels clean. If your home is near a desert or is just in a place with a lot of dirt, they should be hosed weekly. If you are in a non-urban area, clean them bi-monthly. You will receive more power if you keep your panels clean.
A little shadow on your solar panels could reduce output by as much as 80%. Your panels' efficiency will vary greatly depending on location, you can improve efficiency by placing your solar panels away from shadows.
Solar lights are a great option for your home. These lights don't need electrical source. They will accrue solar power through the day and light up at night. This offers a beautiful touch to your front yard or garden.
It is important that you deal with a solar panel company with a sterling reputation. You should ask for references, speak to others that have gotten the panels added to their homes and see if you can find online reviews.If online reviews are not available, seek out a different solar installer.
Solar energy can be used in many different areas of your outdoor spaces. There are several different solar-powered outside light systems to choose from. If electricity is currently powering them, you really ought to consider other alternatives.
Anyone thinking about building their own home is the perfect candidate for using solar energy! South-facing windows get the most heat during the winter. This also blocks the summer sun to reduce any cooling costs.
After considering the information this article entails, you should have an easier experience in deciding how to use solar power in your business or home. Now that you've learned a thing or two about solar energy, you can get started. Renewable energy is wonderful. | <urn:uuid:9375313b-cbba-4f8c-a6c9-561c671c3aef> | CC-MAIN-2022-33 | https://habiganj24x7.blogspot.com/2021/11/thinking-about-exploring-solar-energy.html | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882572161.46/warc/CC-MAIN-20220815054743-20220815084743-00473.warc.gz | en | 0.95077 | 1,181 | 2.625 | 3 |
How to weaken a society
I am better, more precious than you are. I have the right to do whatever it is I am doing and that means you must adjust yourself to my whims….almost seems comical, except when it isn’t.
So it goes the world over. Most times we pay it no mind, or simply say “that’s just the way it is”.
But should it really be like that?
Why do certain people take precedence over other people? Does money make you good? Does it bring you untold advantages that the rest of us never even dream about? Does that big car, extra large house make you any better than the next guy?
I think not. What it means is that you have a big car and extra large house. Period.
We have in this culture begun to equate one with the other. Money equals good, while lack of supposes some flaw in your character. Either you are a ner-do-well or just a slacker without the brains to make a big living.
While spending time in the Mecca of entitlement, Los Angeles, California, I have been “dirty-looked” countless times for not yielding the narrow road to the Rolls Royce convertible….really.
My 2006 Toyota Camry has equal rights to the road, you ‘jack…’. I have been starred at for wearing plain tennis shoes rather than hand made ‘gym-elegant striders’.
Please! What was good enough for Chuck Taylor is good enough for me!
Beyond these simple snubs, let’s look at what we have built as a society. One where we don’t want equality. One which says that sharing is weak, competition is cut throat, and one in which parents pay hundreds of thousands of dollars to get their children into a better school, often times illegally. One where the ends always justify the means. One where racism and bigotry are no longer looked upon as evil, but rather a way to thin the herd and make more for those at the top. One where racism and bigotry are spouted by the heads of state, and where our elected officials are afraid to criticize because it may keep them from getting elected. A very sad state of affairs.
Until we stop looking at these things as minor transgressions and start recognizing them as things that can break down a just and equitable society, we have no chance of equality.
The Buddha said, right thoughts, right words then right actions (something like that) are the building blocks of a greater society. An easy concept to agree with, a difficult one to carry out. We can get complex here and quote all the cliches about Rome not being built…and on and on, but in reality we need to start somewhere.
A simple place is to start with your own self actions. Are they correct for you, whether some one is watching or not?
The next is to make sure our leaders have the same values we have. We can no longer tolerate a President who is fond of making racist remarks…nor a political party that will not stand up to him out of fear. | <urn:uuid:8b6bb4da-c14c-4079-89af-0cfe3c6da60b> | CC-MAIN-2022-33 | https://agnituslife.com/entitlement/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.96811 | 652 | 1.796875 | 2 |
Molly Peacock is the author of The Analyst, a collection of poetry exploring her evolving relationship with Jewish psychoanalyst Joan Stein, With the release of the book today from W. W. Norton & Company, Molly will be guest blogging for the Jewish Book Council all week as part of the Visiting Scribe series here on The ProsenPeople.
I am a goyishe girl, age 9, returning to PS 88 in Buffalo, New York, just after New Year’s Day, 1956, hanging my snow-caked leggings up on a coatroom hook with all the other girls. My fourth grade class is almost exclusively Jewish — except for me, a Protestant, and two Catholics. In Show-and-Tell my girlfriends will show off the poodle skirts they got for Hanukkah, and I will show off the poodle skirt I got for Christmas.
1956 is the same year that my future psychotherapist, Joan Stein, one of the few Jewish women in her class, graduates from Radcliffe. When I meet her in 1974, I am about to be divorced and in despair. So will begin our 38-year psychoanalytic relationship. It will last until 2012, when a devastating stroke will force her to close her practice. Astonishingly, a new relationship will begin, one in which I get to watch the woman who helped me with every major decision of my life make the choices that will infuse her end game with the power and light of painting. All this is part of the backstory of The Analyst, a book of poems about this remarkable woman, about the power of art, and about how, post-analysis, an unlikely friendship began.
In my writing this week, I’m tracking Joan’s and my story, starting with my childhood, of course. My mother, a raven-haired Irish farm girl who married a Navy man with PTSD (though no one called those violent, alcoholic vets victims of war trauma then), determined that her daughter must have the best chance in life. She convinced my father and grandparents to buy a duplex in the north of Buffalo, where the public library is a wonderland, where kids catapult through elementary school, and where almost everyone is Jewish. I am the only goy in my Brownie troupe. After school I visit my friends’ houses where their bubbies dole out almond cookies, their sleeves slipping upwards to reveal the numbers on their arms. And in these houses, larger than mine, darker inside than mine, the light seeming not to come from lamps but from the polish on the massive mahogany furniture, I hear the stories about children who used their wits to survive.
Wits! I need my wits not to perish in a household where my mother instructs me always to put the knives away immediately after they are washed. You never know what my father, the man who tried to push her down the cellar stairs, who hurls plates, glasses, and beer bottles, shards flying, will do when drunk and out of control. Inside my house, I fear for my life. (Not that I mentioned this to anyone until I met my analyst.)
Meanwhile, mild-mannered fathers read the newspapers in my friends’ houses. Mothers take the time to lie down on the couch with a headache. Arguments ensue about the Rosenbergs. Bubbies plunk babkas on those mahogany tables. My friends are grilled about what they learned in school, and I am grilled, too, a little girl with a Jewish name, Molly. “I’m an Irish Molly,” I patiently explain. Stories of the camps unfold, including the story of a boy standing in line for the lethal showers who suddenly drops to the floor, using his wits to save his life:
As the line shuffled toward the gas chamber and the soap was doled out, the boy spied an abandoned mop and pail when commanded by an officer to deliver a message. The boy scrambled to the pail, picked up the mop and started swabbing. The line moved on, and the boy who seized his chance survived.
If only I could be like that boy, I thought. He became my example of kid resourcefulness. If only I could summon up his vigilance to protect myself. The difference between my friends and me is not only whether you get one bonanza of presents under tree or you stretch it out for eight nights. The difference is blue-collar violence.
In Boston, my future psychotherapist is also protecting herself, in quite a different way: by stalking out of an art class.
Eighteen years later I will tell her the story of the vigilant boy in the camps.
Molly Peacock is the author of six previous collections of poetry, including The Second Blush and Cornucopia: New and Selected Poems. Her poems are included in The Oxford Book of American Poetry and appear in leading literary journals internationally. President Emerita of the Poetry Society of America, she co-created Poetry in Motion, a program of placards on subways and buses. Awarded fellowships from the Ingram Merrill, Woodrow Wilson, and Leon Levy Foundations, the National Endowment for the Arts, and the Canada Council for the Arts, Peacock is also author of a biography, The Paper Garden: Mrs. Delany Begins Her Life’s Work at 72, and a memoir, Paradise, Piece by Piece. She is based in Toronto and New York. | <urn:uuid:1528a0db-8155-46b7-a2ea-2b3129f5550a> | CC-MAIN-2022-33 | https://www.jewishbookcouncil.org/pb-daily/im-an-irish-molly | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.952032 | 1,143 | 1.585938 | 2 |
Posting date: 26 December 2019
This position has now been filled.
As datasets in astronomy grow larger and more complex, data analysis and visualization are essential for astronomical research, yet there are few opportunities for astronomers to become experts in data-intensive skills. The Carpentries (formerly Software and Data Carpentry) have a long history of training scientists in foundational computational and data science skills. The Astronomy Curriculum Development Committee (ACDC) has received funding from the American Institute of Physics through the American Astronomical Society to support the development of a data science curriculum for Astronomy. The Carpentries is seeking a six-month part-time curriculum developer (20 hours per week) to work alongside the ACDC to create open-source Data Carpentry lessons for astronomy in advanced Python, data management, and data visualization.
Scope of Work
The successful candidate will be managed by The Carpentries staff and work closely with the ACDC to develop 3-4 self-contained Carpentries-style lessons on predefined topics of data organization, data management, interactive data visualization, and publishing data for longevity and interactivity. The lesson development process will be supported by regular reviews by the ACDC via remote meetings and GitHub project management tools. The lesson developer will present the completed lessons for community review and incorporate feedback. There is the possibility for the lesson developer to teach the lessons at a future national meeting of the American Astronomical Society.
- Certified Carpentries instructor or similar teaching certification
- Familiarity with or desire to learn Bokeh or similar Python interactive visualization (e.g., Altair)
- Familiarity with astronomical concepts equivalent to that gained from an undergraduate degree in astronomy
- Able to teach advanced topics in Python (e.g., classes and scientific packages such as Pandas and Astropy)
- Experience working with Git and using open source features of GitHub (e.g., issues, reviewing, pull requests)
- Excellent written and real-time communication skills
- Knowledge of astronomical datasets (e.g., Vizier hosted catalogs)
- Familiarity with or desire to learn cloud application platforms (e.g., Heroku, AWS, Azure)
- Experience teaching Carpentries workshops or similar
- Curriculum development experience (ideally collaborative)
- Experience with reproducible science
Our team values openness, honesty, fairness, and transparency as the keys to fostering trust. We believe that individuals are the most important part of our organisation and our strongest resource. We strive to make decisions that prioritize people first and empower the growth and success of all who are part of our organisation. We value a growth mindset in all that we do and strive to be always improving and evolving ourselves and our methodologies, being receptive to feedback, responsive, curious, and willing to learn.
About The Carpentries
We’re a core team of eleven staff and independent contractors, with a nine person Executive Council. We’re a fiscally sponsored project of the 501(c)3 Community Initiatives. We have a large community of instructors and contributors, and a much larger community of users. We use evidence-based teaching practices to teach the core skills for effective computational and data work, and we promote reproducible research and open science/open source widely. All interactions in The Carpentries community and spaces, both virtual and in-person, are governed by our Code of Conduct.
About Astronomy Curriculum Development Committee (ACDC)
ACDC is comprised of Azalee Bostroem, Rodolfo Montez Jr., Phil Rosenfield, Diane Frendak, Susan White, and Erin Becker. We represent the intersection of astronomers, statisticians, and educators who together recognize the rising importance of data skills to the astronomical community and the scarcity of training resources. We are committed to working with the astronomical community to meet this need with the development of a two-day Data Carpentry workshop curriculum.
This is a remote position with The Carpentries fiscal sponsor, Community Initiatives. Compensation will be USD $20-40/hr, dependent on experience.
In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire. We are not able to offer employment-based visa sponsorship for this position.
Equal Employment Opportunity
Community Initiatives is an equal opportunity employer and gives consideration for employment to qualified applicants without regard to age, race, color, religion, creed, sex, sexual orientation, gender identity or expression, national origin, marital status, disability or protected veteran status, or any other status or characteristic protected by federal, state, or local law.
We will be evaluating candidates on this application alone, you should not submit a cover letter or CV. Please email [email protected] if you have any questions.
Applications received before midnight Pacific January, 16 2020 will receive full consideration. | <urn:uuid:70de1527-0f0e-40eb-ac5c-778b00738dd7> | CC-MAIN-2022-33 | https://carpentries.org/astronomy-curriculum-developer/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.900775 | 1,055 | 2.0625 | 2 |
The Society holds a major open exhibition in London, usually annually. In its aim to provide educational content to the public our show contains a variety of work of different subjects, genres, media and content. The consistent theme is that the work is of an excellent standard and is by artists who are at the top of their game. Going forward our exhibitions are titled ‘Plantae’ and encompass the entire plant kingdom, with every art form included, from botanical art to illustration – in fact anything that has plants as the main subject. Media used include watercolour, oil, gouache, graphite, colour pencil, as well as hand pulled prints of many kinds and 3-dimensional work, including glass, sculpture and jewellery. The only criteria is that the work must be excellent and any botanical details must be accurate.
Since 2010, biennial exhibitions have been held at the prestigious Palmengarten Frankfurt, Germany, where interest in the Society has developed steadily ever since.
The Society occasionally stages exhibitions in conjunction with galleries and garden venues throughout England, Wales and further afield whilst its members frequently feature in solo and group exhibitions throughout the UK and overseas. The Society is always interested to hear of additional venues and opportunities to display the magical work of its members. | <urn:uuid:b1cc72a0-756f-4a4b-8c9d-f18bb51f34e0> | CC-MAIN-2022-33 | https://www.soc-botanical-artists.org/exhibitions/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573540.20/warc/CC-MAIN-20220819005802-20220819035802-00473.warc.gz | en | 0.969921 | 262 | 1.726563 | 2 |
Tom Jipping, a senior legal fellow at The Heritage Foundation, joins the podcast to explain the Equal Rights Amendment. He also discusses why Virginia technically can’t be the 38th state to ratify it—even though the Legislature claimed Monday to have done so. Listen on the podcast, or read a lightly edited transcript of the interview, posted below.
We also cover these stories:
- President Donald Trump announced a new Middle East two-state peace plan on Tuesday.
- Trump gave a shoutout to Secretary of State Mike Pompeo after Pompeo’s run-in with an NPR reporter.
- The Centers for Disease Control and Prevention announced Tuesday that it is adding more screenings at borders and airports in the U.S. for coronavirus.
The Daily Signal podcast is available on Ricochet, iTunes, SoundCloud, Google Play, or Stitcher. All of our podcasts can be found at DailySignal.com/podcasts. If you like what you hear, please leave a review. You can also leave us a message at 202-608-6205 or write us at [email protected]. Enjoy the show!
Rachel del Guidice: We are joined today on The Daily Signal Podcast by Tom Jipping. He’s the deputy director of the Edwin Meese III Center for Legal and Judicial Studies and senior legal fellow at The Heritage Foundation. He is also the author of a new Heritage Foundation report, “The 1972 Equal Rights Amendment Can No Longer Be Ratified—Because It No Longer Exists.” Tom, thank you so much for being with us today.
Jipping: Thanks for having me.
del Guidice: So on Monday, Virginia passed the Equal Rights Amendment, or the ERA. Before we get started, can you just kind of briefly go over what the ERA is?
Jipping: Sure. The Equal Rights Amendment is a proposed amendment to the U.S. Constitution. The effort to make it part of the Constitution has been going on since the 1920s, and proposals to send it to the states have been introduced in Congress more than a thousand times over those years.
It got the two-thirds vote of both houses of Congress that the Constitution requires only once and that was in 1972, and that sent the ERA to the states. The Constitution requires that three-quarters of the states must ratify an amendment before it becomes part of the Constitution.
In terms of what the ERA says, the version that was sent to the states in 1972 is very short. It simply says that that rights shall not be denied based on sex. And it was increasingly controversial when it was proposed in the 1970s, a lot of states ratified it quite quickly, and then that progress slowed dramatically as different organizations really urged state legislatures to examine not just the words of it, which sound pretty simple, but what it could be used to do.
As a result, a total of 35 states ratified it by the deadline. It did have a seven-year deadline when it was proposed, so that deadline would have been in March of 1979. And then Congress extended it once to June 30, 1982. And when that deadline passed and there weren’t three-quarters of the states on board, the ERA effectively died.
The reason we’re talking about it today is that after about kind of 20-25 years of just sort of sitting there, some ERA activists and some feminist organizations started thinking a little more creatively, if they could get the progress going, could they pick up where they left off back in 1982?
And some made the argument that states could still ratify the 1972 ERA and if they had three more states, that would get them to 38, that was three-quarters, and bingo, it would happen.
So, Nevada ratified in 2017, Illinois ratified in 2018, and now Virginia claims to be the 38th state to ratify the Equal Rights Amendment.
In my paper, I explain what really is a pretty commonsense idea. The deadline was a deadline, June 30, 1982. After that date, the ERA no longer existed. It wasn’t pending before the states anymore. So, whatever it is that Virginia says that it did, you can’t ratify a constitutional amendment that doesn’t exist.
If activists want the ERA be part of the Constitution, they’re going to have to start over again. They’re going to have to get Congress to propose it again and get it to the states for ratification. But the 1972 ERA is dead.
del Guidice: So proponents of the ERA, a local Richmond news station had said that these people are saying that the amendment will enshrine equality for women in the Constitution. Would you say, knowing what the ERA is, is that the case?
Jipping: As I said, the debate about what the ERA would or wouldn’t do, either intended or unintended consequences, has been going on since literally the 1920s.
In the very beginning, believe it or not, feminist groups and labor unions strongly opposed the ERA because they said it could be used to prevent legislation that would actually benefit women. Today, those roles are reversed, but there’s a lot of discussion and has been since it was proposed in 1972 about how much mischief it could actually be used for.
… This goes to your question as well, the other debate is whether existing law, either provisions of the Constitution, state constitutions, many states have passed their own ERAs, whether those laws that are in place today, that certainly weren’t in place in the 1970s, provide the legal protection that women need.
There’s certainly debates about those questions. I do think that the threat or the possibility that something even as simple as the ERA could be used, especially in the courts, for all kinds of other things. I think that danger is much more real today even than it was in 1972.
We see all the time groups going to the courts with a Constitution that says one thing and they persuade judges that it says something else. And we end up changing the country in profound ways that were never intended. And I think whether it’s abortion, the LGBT agenda, all sorts of things that would very definitely be on the litigation agenda, should the ERA become part of the Constitution.
del Guidice: You touched on this a bit earlier, but to drill down into it a little bit more, Virginia is claiming, as you mentioned, to be the 38th state to pass the ERA. So does that mean that it’s now a constitutional amendment? You hinted on this, but just to clarify for everyone listening.
Jipping: The process, and this is laid out by a federal statute, once a state does what Virginia did, it sends what the statute calls ratifying documents to the Office of the Federal Register—that’s an agency here in Washington that publishes the federal register, which is a record of regulations.
Once the Office of Federal Register has received those documents from 38 states, they notify the archivist of the United States and then the archivist does a review of those documents for what the statute calls legal sufficiency. Basically just to make sure that they’re legally sound.
And then if there are 38 states’ ratifications that are legally sound, it becomes part of the Constitution. Congress has no role, they don’t have to take any vote. The president isn’t involved.
So the question is, if the ERA expired in 1982, if it literally was not available for ratification, when these documents get here to Washington and the archivist does his review, what’s he going to say? Can he say that ratification of a amendment that doesn’t exist is legally sound? I don’t think so. But that’s the process that is spelled out in federal statute.
And I suppose almost everything ends up in court at some point in this country. So, I suppose at some point thereafter there might be a lawsuit. But that’s what has to happen next.
del Guidice: Five states tried to take back their support of the ERA. Can a state do that?
Jipping: Well, that’s an important part of the ERA story. As I said, the effort to get states to ratify the ERA really took off in 1972, and a couple of dozen states very quickly ratified it. Not only did the pace of new states dwindle, but because of the rapidly increasing opposition, as you said, five of the states that did ratify, they rescinded that ratification.I believe those rescissions are valid.
In other words, until 38 states ratify the amendment, it’s not an amendment. It’s not part of the Constitution. It’s still pending. And a state can make its decision, they can change their mind, they can do one thing one year and five years later, undo it if they want. Until that ratification deadline happens, the amendment is pending and as long as it’s pending, states can do what they want to do.
In my opinion, by the deadline, by the 1982 deadline, only 30 states had validly ratified the ERA and they would’ve needed eight more. But my dad said close count only counts in tiddlywinks or horseshoes or something and 35 is just as far away from 38 as 30 is. Either way, the ERA is dead.
del Guidice: In 2019, there was a House committee that passed a bill that would have removed the 1982 deadline for the ERA. So could the Senate and House, hypothetically speaking, retroactively remove that 1982 deadline and let the Equal Rights Amendment move forth?
Jipping: No. As I said, June 30, 1982, the ERA is dead. Congress cannot amend a bill that has failed. That would be like introducing an amendment today to a bill that was introduced three years ago or something like that. It doesn’t exist. A deadline is a deadline.
The Constitution gives Congress a significant authority to propose constitutional amendments and the Supreme Court has held clearly that that includes the authority to set a deadline. Congress did that. The deadline is passed. Everyone knows what a deadline is. The deadline has passed. As frustrating as that might be to some political activists, as much as people might wish that hadn’t happened, it did.
The Congressional Research Service, which, as I’m sure you know, is a well-respected, widely used resource of nonpartisan research—when I worked in the United States Senate, we relied on them frequently—they’ve published a huge work about the Constitution and its interpretation. I mean, it’s literally almost 3,000 pages long, covering every subject imaginable.
And for more than 20 years, the Congressional Research Service has said that on June 30, 1982, the ERA died. We can make, and lawyers can make, any subject really complicated no matter how simple it is, but that’s the deadline. It passed. The ERA is dead.
del Guidice: So you have people celebrating it even still, even though we have this deadline that has passed, and if these advocates still wanted to go about and actually do this the right way, how would they go about doing that? Would they reintroduce it? What are the steps to that?
Jipping: The process is the same as they did for the 1972 ERA. A member of Congress would introduce a joint resolution that includes a deadline, if there is one. It designates whether states must ratify the amendment by legislature or convention. And then it includes the language of the amendment.
If two-thirds of Congress pass that, it gets sent to the states, three-fourths of the states ratify it, it becomes part of the Constitution. So that process has to start over.
As I said, since the ’20s, those resolutions to propose the ERA have been introduced over a thousand times. Everybody knows that that’s the process and that if it doesn’t work the first time, you do it again, you start over.
As I say, I realize that’s frustrating. With the opposition to the original ERA there’d probably be more opposition now, and so the likelihood that it would become part of the Constitution is probably lower.
I can see where they would want to grasp whatever strategy they thought could give them a leg up on that, but this isn’t it. The deadline passed 37 years ago.
del Guidice: Earlier this week, Virginia Attorney General Mark Herring said per American University Radio, “I am committed as ever to making sure we have and use every single tool at our disposal to make sure the Equal Rights Amendment becomes part of the United States Constitution.” So in his role as Virginia attorney general, is there anything he can do to achieve that?
Jipping: You’ll notice that he didn’t say anything specific about whether the 1972 ERA has in fact been ratified by Virginia. Interestingly, in 1994, the deputy attorney general of Virginia issued an opinion saying specifically, he was responding to a member of the legislature that the ERA was no longer pending and could not be ratified. That was 25 years ago.
So Attorney General Herring I’m not aware has reversed that. What he’s saying is he wants to see the ERA become part of the Constitution. Lots of people do, and there’s a process for that.
del Guidice: Alabama, South Dakota, and Louisiana, they’re suing the head archivist of United States saying that it would be illegal to add the ERA as an amendment. What’s your perspective on that suit and where do you think it will go?
Jipping: As I mentioned about the process, the archivist is sort of the final step of the process. He has to make that review to make sure that the documents he’s received from at least 38 states are legally sound. He hasn’t done that yet, he hasn’t made any decision on that yet. So the lawsuit is probably a little premature, but they’re focusing it in the right place.
In other words, they’re following federal statute as to what the process actually is. It doesn’t become part of the Constitution unless the archivist issues a proclamation to that effect. So he’s where the buck stops, and that’s the final decision that has to be made. But they’re right to do it, and it really doesn’t matter whether your state has or hasn’t ratified.
I wish that more people, including in this case, feminist groups and so on, … would be more united on the process that has to be followed for our government to function under the Constitution.
We all ought to agree on that, that the Constitution’s rules apply to everyone. No one gets to skirt around a different way, or come up with a way of avoiding what the Constitution requires. Doesn’t matter what your politics are.
We all ought to respect that and insist that the Constitution’s rules be followed. If we do in this case, the ERA has to start over.
del Guidice: Going off of that point, Tom, really quickly, why don’t you think there were Virginia lawmakers—maybe there were a few, I didn’t see any and I could have missed it—that said, “Hey, this deadline has been missed. We have no business doing this”?
Jipping: Unfortunately, I think we have more politicians than statesman in a lot of our legislatures. I saw quotes from members of the Virginia Legislature, including Republicans, who said, “Well, just let the courts sort that out. This is an important time to take a stand so let’s just let the courts figure that out.”
That’s a complete abdication of their responsibility and it violates their oath of office. They took an oath to support and defend the Constitution and that includes the Constitution’s rules for amending it. And so to simply kind of duck out of that and weasel out of that responsibility and just say, “Ah, the courts will sort it out,”—good grief.
The courts have done enough damage to our country in taking authority away from our elected representatives and away from the people for making these kinds of decisions. That was more than disappointing to hear that.
We ought to have our representatives follow their oath of office, insist on those basic rules, and then we can handle and address our political differences.
But if the system itself is going to crumble because our elected representatives don’t care about it, then we’re in bigger trouble than I thought.
del Guidice: Tom, you mentioned this a little bit earlier, but saying that everything usually ends up in court at some point in time. So, … depending on what happens with different states ratifying, do you foresee a legal battle at some point with the ERA?
Jipping: Well, I do. If, for example, the archivist were to say, as I think he should, that the last three states to supposedly ratify—that would be Nevada, Illinois in Virginia—their ratifications are not legally sound, and shouldn’t be recognized, then I suppose there might be states in left-wing groups that would go to court to try to force him to do that.
… There’s a lot at stake with something that is this symbolic, something that has been around this long. It stands for an awful lot, both positively and negatively. So a lot of political interest would see, one way or another, that their interests are tied up in the ERA, and that usually means that someone will go to court.
del Guidice: You can find Tom’s report, “The 1972 Equal Rights Amendment Can No Longer Be Ratified“—Because It No Longer Exists on heritage.org if you want to learn more about it. Tom, thank you so much for being with us on The Daily Signal Podcast.
Jipping: Thanks for having me. | <urn:uuid:2e584d36-4759-465f-ac2e-69b7a46b26e0> | CC-MAIN-2022-33 | https://www.dailysignal.com/2020/01/29/everything-you-need-to-know-about-the-equal-rights-amendment/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571989.67/warc/CC-MAIN-20220813232744-20220814022744-00473.warc.gz | en | 0.973272 | 3,808 | 2.015625 | 2 |
If you have Java in your environment you may have already heard that in 2018, Oracle announced deep Java licensing changes to Java Standard Edition (SE) that took effect in January 2019. These changes have left the community with many unanswered questions about licensing and about their environments, not in the least of which is, “What should our Java licensing look like?” Similarly, those who have already made their decision on Java licensing are also left wondering, “Have I under or over provisioned licensing and what’s the impact if I’m not compliant?”
If you’ve been wondering the answer to either one of these questions, this blog post might be for you. But first, let’s review, what were Oracle’s Java licensing changes?
Clearing up the confusion: what are the Java licensing changes?
In short, since January 2019, Oracle no longer issues public updates for commercial users of Java SE 8 which means free updates for commercial use are no more. Oracle has officially moved Java SE to a subscription-based model. Whether an organization has previously purchased a perpetual license of SE or uses OpenJDK, these licensing changes will likely impact any organization looking to keep up with support. Read more about Oracle’s support roadmap for Java SE here.
|Java Platform Products|
|Named User Plus||Software Update License & Support||Processor License||Software Update License & Support|
|Java SE Advanced Desktop||40||8.80||–||–|
|Java SE Advanced||100||22.00||5,000||1,100.00|
|Java SE Suite||300||66.00||15,000||3,300.00|
Prices in US (Dollar)
Source: As dictated in Oracle’s Global Price List last updated June 19, 2018.
Perhaps the easiest way to make sense of the changes is to think of Red Hat’s open source model. Red Hat offers its software for free, but enterprise customers are sold support services and premium subscriptions. In much the same way, the changes Oracle announced mid 2018 are moving Java in that same direction. Oracle will continue to offer its OpenJDK for free, but they will start charging for enterprise support.
So, is Java still free? It depends…
Do I need to start paying for Java licenses?
If any of the following statements apply to you, you will likely require an Oracle license:
– I use commercial features of Java SE
– I use Oracle Java SE v11 +
– I need support from Oracle
– I use Java SE versions for longer than 6 months
– I am running unsupported Java SE in my environment
If you want to use Java for free for commercial use, one way of doing it is to use an Oracle JDK, Oracle’s OpenJDK builds and OpenJDK from other providers. This, of course, does not include support from Oracle, however.
What should my Java licensing and spend look like?
In order to answer this question, you need to have the right data on your environment and determine:
– Where Java is being used and where it has been installed
– Which versions of Java exist in your environment
– What are the applications calling Java
– How many users are there by application
Read this brief on how you can answer these questions
To help answer these questions, we have built a dashboard within SysTrack that pulls exactly this kind of data. For those unfamiliar with SysTrack, it is a solution that monitors any and everything that may be impacting end-user experience which turns out to be tens of thousands of different indicators. SysTrack gathers data on performance and usage of IT products and services and analyzes them directly from each endpoint in the environment. In the context of Java licensing changes, SysTrack data proves to be helpful because not only does it pull the Java versions in the environment and specifically which apps and users are calling it, but SysTrack also gathers and analyzes data on how virtually every IT resource and service is performing and being used, beyond Java. It can report on Office 365 licensing usage so that you can potentially scale back on E5’s just as it can determine critical compute resource usage in virtual environment, like CPU and RAM. Below you will see a screenshot of the type of data SysTrack can report to help make your decision on Java licensing and spend. Request a demo today if interested!
Alternatively, it’s important to point out Oracle has built a license tool that requires its own subscription.
What happens if I don’t purchase the subscription?
It seems the verdict is still out on how Oracle will be auditing for Java licensing and what it will mean should an organization not be compliant. However, should an organization not purchase the subscription, aside from risking non-compliance, at the very least they will be missing out on:
- early access to bug fixes
- licensing and support for cloud, server and desktop deployments
- some performance, stability, and security updates
- around the clock support
- and more (source)
Additionally, when it comes to renewal time, if an organization does not renew the subscription, they lose the rights to any commercial software downloaded during the subscription.
Digital experience monitoring software like SysTrack can help bring visibility into these critical aspects of Java licensing but also into the usage and performance of end-user technology, whether hardware or software. If you’d like to see SysTrack in action, watch this demo!
About Lakeside Software and SysTrack
Lakeside Software is a leader in digital experience monitoring. For 20 years, we have been developing software that helps IT teams have clear visibility into their environments in order to design and support productive digital workplaces. Our customers use Lakeside Software technology to perform workplace analytics, IT asset optimization, and AIOps.
SysTrack is our flagship solution. The digital experience monitoring software gathers and analyzes data on everything that may impact end-user experience and business productivity. Directly from the workspace, SysTrack captures data such as CPU, RAM, memory, and other 10,000+ data points. These are then analyzed by SysTrack and used by IT in countless ways that lower costs and optimize operations including: lowering the amount of help desk tickets, identifying over and under-provisioning, reducing time to resolution, tracking SLA performance, measuring the performance of rollouts, and so much more. | <urn:uuid:84af78b7-e989-4320-8942-851883ea2477> | CC-MAIN-2022-33 | https://www.lakesidesoftware.com/java-did-what-understanding-how-2019-java-licensing-changes-impact-you/?category=533 | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882572304.13/warc/CC-MAIN-20220816120802-20220816150802-00473.warc.gz | en | 0.929314 | 1,340 | 1.59375 | 2 |
Sometimes dog owners face a specific problem – excessive dryness of the nose, which can lead to the appearance of cracks. Since the sense of smell for an animal is very important, cracked skin on dogs’ nose can cause serious complications, especially in the presence of infection in the wounds. It is difficult to determine the causes of this condition, as it can be provoked by different factors.
Dry and hot nose is not always caused by serious diseases, but the appearance of cracks in the background of the inflammatory process, indicate the presence of serious health problems. This is a kind of signal that appropriate measures need to be taken urgently. If a dog has cracked skin on nose, this can be caused by factors such as:
- Heredity and age-related changes. Warm nose for most puppies is a common phenomenon, moreover, for breeds with slow metabolism it is generally a variant of the norm.
- Most pets have dry and warm nose during sleep or immediately after waking up. This is not strange, the condition is quite normal. You should sound the alarm in the event that animal lost its appetite, became sluggish, it has an increase in body temperature and other signs of illness against the background of such a distinctive feature.
- Fatigue. After a long game the animal is not able to regulate the functions of the body well, as a result its nose can be dry.
These causes of warm and dry nose are natural and could not harm the health of the animal. However, cracked skin on dogs’ nose can speak about such serious diseases as:
- Result of injury. The nose shell is very sensitive, when it hits, cracks may occur. This brings discomfort and severe pain to the animal, because it loses the sense of smell, not only as a consequence of cracks in the skin, but also due to bruises and swelling from the impact;
- Infection. In its turn, it is divided into indirect and direct infection. If a dog has cracked skin on nose, the cause may be a bad cold, such a fatal disease as distemper and other infectious diseases. The animal can also bring bacteria and fungi to its nose if there is a source of infection in the mouth or on the body. Infection can be caused by excessive curiosity. The animal can dig sand or ground, trash pile, etc. the result is inflammation and painful cracks;
- Old age. With age, animals have problems with metabolic processes that can cause tissue disease;
- Diseases. Liver damage, diabetes, worm infestation, pemphigus, allergic reaction-all these diseases can cause drying of the nose and as a result – cracks on it;
- Avitaminosis. In young children, cracks in the area of the fingertips can be observed as a result of a lack of vitamins in the body. A dog’s nose is something like that;
- Stress. The body of the animal might react in such a way to any unusual situation.
Since there are many causes of nasal fractures, only a veterinarian can make an accurate diagnosis. Also, a specialist should prescribe treatment, because the use of antibiotics can be not only harmful to health, but also completely useless, for example, with mucosal fungus or worms.
Signs of Pathology
If the reason for cracking nose is pathological, then it is accompanied by the following symptoms:
- Increased dryness of the skin;
- Increase or decrease in body temperature, as well as local temperature increase;
- Absence of appetite;
- Changes in behavior;
- The emergence of regular combs in the affected area;
- Vomiting, nausea;
- Problems with urination and liquid stool.
In the presence of the above mentioned signs, it is recommended to show the pet to a vet to identify the problem and prescribe timely treatment.
Solutions of the Problem
Treatment in this condition should be targeted, directly related to the cause which provoked cracks on the nose. Therefore, the treatment at home can not only be pointless but also dangerous for the animal. First of all, you need to identify the cause of the disease, and on this basis, the vet will prescribe medications and procedures.
Dry surface of the nose can be lubricated with Trivita vitamin solution, ointments for the appointment of a veterinarian. It is necessary to exclude the possibility of injury and rubbing this area with a muzzle, which can only aggravate the condition. In addition, the animal must stay calm and clean. You should ensure balanced diet and adhere to the full course of treatment prescribed by a veterinarian. | <urn:uuid:bfaddb4a-2822-40d5-9a4f-36a3e4169fff> | CC-MAIN-2022-33 | http://doggyhealthy.com/cracks-on-a-dog-s-nose.html | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573540.20/warc/CC-MAIN-20220819005802-20220819035802-00473.warc.gz | en | 0.946893 | 953 | 2.671875 | 3 |
Owen Jones says Brexit museum is ‘really weird’ idea
The UK Internal Market Bill was designed as a solution by ministers to creating a secure platform for UK trade after Britain fully cut ties with the EU. It also saw measures which were previously managed by the EU return to the UK.
Around 160 policy areas including animal welfare, public procurement rules and environmental regulations will go to one or more of the devolved administrations.
But concerns were raised that the new legislation, passed in December, would constrain the devolved parliament’s powers with the Welsh Senedd and Holyrood both refusing legal consent for the bill.
The two devolved parliament's decisions were both overruled by Westminster.
Now a report by the House of Lords Common Frameworks Scrutiny Committee claims Brexit “damaged relations” between the devolved governments.
The report concluded that Brexit has put “significant strain” on the unity of the four nations
The report also claims Brexit has put “significant strain” on the relationships and called for “intergovernmental relations” to be reset.
The unelected peers also suggested the House of Lords act as a neutral forum which would encourage devolved administrations to work together.
Baroness Andrews, chair of the Common Frameworks Scrutiny Committee said the relationships between the UK Government and devolved administrations were “severely strained”.
She added: “We believe that the collaborative approach of common frameworks should be used as a model to reset UK intergovernmental relations and build a co-operative Union.”
Baroness Andrews continued: “Common frameworks are a crucial legacy of leaving the EU that has too often been overlooked.
“They create the processes necessary for day-to-day co-operation across the UK in areas such as food safety, farming and the environment.
“During the committee’s inquiry, we found widespread support for common frameworks across sectors and in every part of the UK.
“However, the UK Internal Market Act has clearly damaged relations with the devolved administrations and could severely compromise the common frameworks programme.
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“We also have concerns about transparency and how the frameworks will relate to the Northern Ireland Protocol.”
It comes after ministers for Scotland, Wales and Northern Ireland joined forces to demand an urgent meeting with Treasury bosses, as they accused the UK Government of bypassing the devolved governments.
The call came after talks between Scottish public finance minister Ivan McKee, and the finance ministers in Northern Ireland and Wales, Conor Murphy and Rebecca Evans.
In a joint statement, the trio sought to highlight their "shared concerns about the UK Government's decision to bypass democratically agreed devolution arrangements" by funding projects in their nations under the Levelling Up scheme and Community Renewal Funds.
Mr McKee, Mr Murphy and Ms Evans insisted that money to replace cash from European Union (EU) funds should be "allocated in full" by their devolved Governments.
A UK Government spokesperson said: “Now more than ever, people across the UK want to see the UK Government and the devolved administrations working together to protect lives and livelihoods. As our collective response to this pandemic has shown we are at our strongest when we work together towards a common goal.
"The UK Internal Market Act ensures that UK companies can continue to trade seamlessly across every part of the UK, protecting the Internal Market whilst safeguarding the devolved administrations' right to regulate in devolved areas as they do now. | <urn:uuid:1492f845-ee10-4d6c-b038-a79b035a5c0d> | CC-MAIN-2022-33 | https://www.express.co.uk/news/politics/1417443/brexit-news-house-of-lords-uk-internal-market-bill-union-relations | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.953311 | 793 | 1.796875 | 2 |
The report foresees the rules for durable medical equipment becoming increasingly inadequate to keep pace with technology advances, and wants a review of policies.
A report from the Government Accountability Office (GAO) calls for a review of Medicare’s policies for covering durable medical equipment (DME), and asks CMS to weigh changes that would extend coverage to novel devices and encourage innovation.
Historically, Medicare will not pay for devices that don’t meet the DME test: the device must serve a medical purpose, can withstand repeated use, and have an expected life of 3 years. As technology advances, however, the lines are blurring between durable and disposable technology, and some devices that combine both—with potential to help patients achieve better glycemic control or greatly improved sleep—will fall outside current definitions. GAO predicts missed opportunities to keep patients healthy, and thus wants to review DME payment policies.
Allowing payment for disposable medical equipment—or asking Congress to create a new benefit category—might prevent head-scratchers like a call the report cites: Earlier this year, CMS made a breakthrough policy change when it ruled that certain seniors with diabetes could have a Dexcom G5 continuous glucose monitor. But then a Medicare Administrative Contractor said seniors could only be reimbursed if they didn’t use the Dexcom with their smartphone.
That ruling, reported by The American Journal of Managed Care®, was specifically cited by GAO as an example of how “CMS has already faced issues accommodating new technology.”
The report found that CMS’ challenges with technology will only increase as devices like new versions of the artificial pancreas get closer to completion. Increasingly, traditional medical device companies are working with technology giants like Google and Apple to create products that require minimal interaction from patients with diabetes and chronic disease.
Their goal: if medical devices have the usability of a smartphone, patients will stick with them and stay healthy, while feeding data to their doctors and health systems. Thus, devices will easily track progress at both the individual and population health level. Already, device and technology companies are forming partnerships with these goals in mind. Devices will soon become smaller and cheaper, which should also appeal to Medicare.
GAO’s report examined several types of devices: durable and disposable insulin pumps, infusion pumps, and blood glucose monitors. Insulin pumps that have both durable and disposable components present the current challenge, because Medicare has refused to pay for at least one popular pump (which appears to be Insulet's Omnipod based on the description in the report) after ruling its insulin delivery mechanism is disposable even though the bulk of the device lasts more than 3 years. This is the type of hair-splitting where GAO sees future problems. Six of 21 stakeholders interviewed for the report said medical device technology is advancing, and 5 “specifically cited CMS’ definition of DME as a disincentive to technological innovation, such as the development of disposable substitutes.”
“As advancing technology results in changes to the functionality of devices, including the development of disposable substitutes, CMS will likely have to consider how its benefit coverage policies will apply to them,” the report stated.
Disposable substitutes for DME can have certain advantages: some disposable models are lighter and quieter; with certain patients, disposable products can promote adherence if it's not necessary to clean and transport supplies, as it is for durable products. In some care settings, disposal products reduce nurses’ workloads and prevent infection. On the downside, DME varieties are preferred when dosing needs to be highly specific.
The GAO report goes into detail on several potential DME substitutes, with their potential benefits and limitations; it outlines the current incentives and disincentives for developing disposable DME substitutes. Lack of Medicare reimbursement for disposable equipment topped the list of barriers.
What can be done? The GAO recommended the following:
GAO reports that HHS, which includes CMS, believes this type of evaluation is premature. But GAO says it “continues to believe an evaluation is needed to help HHS anticipate and plan for significant changes using a forward-looking process.” | <urn:uuid:eb874ebb-9a63-4941-bc82-08aa4fc07be3> | CC-MAIN-2022-33 | https://www.ajmc.com/view/gao-review-medicares-approach-to-covering-medical-equipment-including-insulin-pumps | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.949922 | 855 | 2.21875 | 2 |
Automotive Body and Glass Repairers
Automotive body and glass repairers restore, refinish, and replace vehicle bodies and frames, windshields, and window glass.
Automotive body and glass repairers typically do the following:
- Review damage reports, prepare cost estimates, and plan work
- Remove damaged body parts, including bumpers, fenders, hoods, grilles, and trim
- Realign car frames and chassis to repair structural damage
- Hammer out or patch dents, dimples, and other minor body damage
- Fit, attach, and weld replacement parts into place
- Install and weatherproof windows and windshields
- Grind, sand, buff, and prime refurbished and repaired surfaces
- Apply new finish to restored body parts
Automotive body and glass repairers can repair most damage from everyday vehicle collisions and make vehicles look and drive like new. Damage may be minor, such as replacing a cracked windshield, or major, such as replacing an entire door panel.
Repair technicians use many tools for their work. To remove damaged parts, such as bumpers and door panels, they use pneumatic tools, metal-cutting guns, and plasma cutters. For major structural repairs, such as aligning the body, they often use heavy-duty hydraulic jacks and hammers. For some work, they use common handtools, such as metal files, pliers, wrenches, hammers, and screwdrivers.
In some cases, repair technicians do an entire job by themselves. In other cases, especially in large shops, they use an assembly line approach in which they work as a team with each repair technician specializing.
Although repair technicians sometimes prime and paint repaired parts, automotive painters generally perform these tasks. For more information, see the profile on painting and coating workers.
The following are occupational specialties:
Automotive body and related repairers, or collision repair technicians, straighten metal panels, remove dents, and replace parts that cannot be fixed. Although they repair all types of vehicles, most work primarily on cars, sport utility vehicles, and small trucks.
Automotive glass installers and repairers remove and replace broken, cracked, or pitted windshields and window glass. They also weatherproof newly installed windows and windshields with chemical treatments.
Glaziers install glass in windows, skylights, storefronts, and display cases to create distinctive designs or reduce the need for artificial lighting.
Glaziers typically do the following:
- Follow blueprints or specifications for size, color, type, and thickness of glass to be used
- Remove any old or broken glass before installing replacement glass
- Cut glass to the specified size and shape
- Make or install sashes or moldings for glass installation
- Fasten glass into sashes or frames with clips, moldings, or other types of fasteners
- Add weather seal or putty around pane edges to seal joints
Glass has many uses in modern life. For example, insulated and specially treated glass keeps in warm or cool air and controls sound and condensation. Tempered and laminated glass makes doors and windows more secure. The creative use of large windows, glass doors, skylights, and sunroom additions makes buildings bright, airy, and inviting. Glaziers specialize in installing these different glass products.
In homes, glaziers install or replace windows, mirrors, shower doors, and bathtub enclosures. They fit glass for tabletops and display cases. On commercial interior projects, glaziers install items such as heavy, often etched, decorative room dividers or security windows. Glazing projects also may involve replacing storefront windows for supermarkets, auto dealerships, banks, and so on.
Workers who replace and repair glass in motor vehicles are not covered in this profile. For more information, see the profile on automotive body and glass repairers.
For most large scale construction jobs, glass is precut and mounted into frames at a factory or a contractor's shop. The finished glass arrives at the jobsite ready for glaziers to position and secure into place. Using cranes or hoists with suction cups, workers lift large, heavy pieces of glass for installation. In cases where the glass is not secure inside the frame, glaziers may attach steel and aluminum sashes or frames to the building, and then secure the glass with clips, moldings, or other types of fasteners.
A few glaziers work with plastics, granite, marble, and other materials used as glass substitutes. Some work with films or laminates that improve the durability or safety of the glass. | <urn:uuid:328b90ef-8671-4b57-934d-6d126f608e14> | CC-MAIN-2022-33 | https://www.claimspages.com/providers/oklahoma/glass/a-better-glass-co/918-830-4056/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573104.24/warc/CC-MAIN-20220817183340-20220817213340-00473.warc.gz | en | 0.913632 | 963 | 2.078125 | 2 |
More and more jurisdictions are passing laws requiring employers to provide sick leave to employees. Employers that are subject to paid sick leave requirements often have questions about the impact of these laws on their existing paid time off (PTO) policies. Here are some frequently asked questions on paid sick leave and PTO:
Q: Where is paid sick leave required?
A: Currently, the following jurisdictions require (or will soon require) employers to provide paid sick leave to employees:
- Connecticut (employers with more than 50 employees must provide paid sick leave to "service employees")
- Michigan (employers with 50 or more employees must provide paid medical leave)
- New Jersey
- Rhode Island
- San Antonio, Texas (effective December 1, 2019 for employers with more than five employees, but August 1, 2021 for smaller employers). This ordinance is currently being challenged in court. We will continue to monitor and report updates on the status of the law.
- Dallas, Texas (effective August 1, 2019 for employers with more than five employees, but August 1, 2021, for smaller employers). This ordinance is currently being challenged in court. The city says it will delay enforcing all but the anti-retaliation provision until April 1, 2020. We will continue to monitor and report updates on the status of the law.
- Cook County, Illinois
- District of Columbia
- Cities in California: Berkeley, Emeryville, Oakland, San Francisco, Santa Monica, San Diego, Long Beach (hotels with 100 or more rooms), and Los Angeles
- Cities in Minnesota: Duluth (Effective January 1, 2020), Minneapolis and St. Paul
- Montgomery County, Maryland
- New York City
- Westchester County New York
- Cities in Pennsylvania: Philadelphia and Pittsburgh (effective date to be decided)
- Cities in Washington: Seattle, Tacoma, and SeaTac (hospitality and transportation industries)
Note: In 2019, Maine and Nevada enacted laws that require employers to provide their employees with paid time off that can be used for any reason. In Maine, the requirement will apply to employers with more than 10 employees and takes effect on January 1, 2021. In Nevada, the requirement will apply to employers with 50 or more employees and takes effect on January 1, 2020.
Updated: November 2019
Q: What is the difference between a paid sick leave policy and a PTO policy?
A: A paid sick leave policy is a standalone policy that offers time off for illness and certain other situations. A PTO policy bundles various types of leave, such as vacation, sick, and personal leave, into a single bank that employees can use for any purpose.
Q: My state requires me to provide paid sick leave to employees. Can I keep my current PTO policy?
A: Under many of the paid sick leave laws, if you have a PTO policy, you generally don't have to provide additional paid sick days to employees if the policy:
- Allows employees to use the same amount of leave for the same purposes and under the same conditions as required by the sick leave law; and
- Satisfies the accrual, carry over, and use requirements of the sick leave law.
Check your applicable law to ensure compliance.
Q: My state paid sick leave law allows me to provide leave through a PTO policy. One of my employees just requested sick leave, but he has exhausted all of his PTO for the year on vacation. Do I have to offer additional paid leave to this employee?
A: Under many of the paid sick leave laws, no additional leave would be required if the PTO policy met the requirements listed in the answer above. When implementing your PTO policy, to help your employees manage their time off, clearly communicate what they can use PTO for, how it accrues, and the other requirements of your plan. Depending on the circumstances, the employee here may qualify for sick leave (typically unpaid) under a different law. For example, the federal Family and Medical Leave Act requires employers with 50 or more employees to provide unpaid leave to eligible employees for specified family, medical, and military reasons. Many states have similar laws that cover employers with fewer employees. Check your applicable laws to ensure compliance.
Q: What are some advantages and disadvantages of having a PTO policy instead of a standalone paid sick leave policy?
A: In general, PTO policies give workers more flexibility to use their leave to fit their needs. For employers with employees in multiple jurisdictions with differing paid sick leave requirements, a PTO policy can be an attractive option because a single policy (and the same amount of leave) can generally be offered across jurisdictions, provided it meets the requirements of the most generous paid sick leave law.
Another advantage of a PTO policy is that it can ease the administrative burden of tracking precisely how the leave was used. However, employers should still familiarize themselves with their obligations under applicable paid sick leave laws, since many have specific recordkeeping requirements.
Sick leave laws don’t typically require that employers pay for unused sick leave when an employee leaves the company. However, if you use your PTO policy to meet sick leave requirements, in some states, such as California, you would be required to pay out all unused PTO at the time of separation. This could mean employers would face additional costs paying for unused sick time if they bundled their sick leave into their PTO rather than if they offered separate sick leave. In some states, this may also be true if the employer uses a vacation policy to satisfy the sick leave law.
Note: Seattle's paid sick leave law requires employers with 250 or more full-time equivalent employees to provide more time off to employees if they maintain a PTO policy instead of a standalone sick leave policy (108 hours versus 72 hours).
When determining whether to have a PTO policy or separate sick leave policy, identify your specific business needs and evaluate the laws that apply to your employees. | <urn:uuid:550b79af-66e0-4db5-ac9c-1077ca8e82a4> | CC-MAIN-2022-33 | https://sbshrs.adpinfo.com/blog/paid-sick-leave-vs-pto-frequently-asked-questions | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.948268 | 1,258 | 1.632813 | 2 |
Kaiser Health Tracking Poll: April 2016
The April Kaiser Health Tracking Poll examines public opinion on the severity of health problems in the U.S. and takes a closer look at attitudes towards current health problems; including access to substance abuse treatment and mental health services.
- Cancer tops the public’s list of extremely serious health problems in the U.S., followed by contaminated drinking water, heroin abuse, two topics that have garnered media attention recently.
- Although heroin technically falls into the same opioid family as prescription painkillers, Americans perceptions of the seriousness of addiction to these two drugs as well as the discrimination faced by those who use them are different.
- Forty-four percent say they personally know someone who has been addicted to prescription painkillers; a majority of Americans say that lack of access to care for people with substance abuse issues is a problem.
- A quarter report that a doctor or health professional has told them or another family member living in their household that they have a serious mental health condition; 21 percent report that there has been a time when they or another family member thought they might need mental health services but did not get them.
- Many Americans are unaware of the legal requirement that insurance plans must have the same rules for mental health benefits and substance abuse treatment as other medical services.
Serious Health Problems in the U.S.
When given a list of health issues facing the country, cancer tops the list, with 43 percent saying it is an extremely serious problem. In the midst of news stories about the contamination of the water in Flint, Michigan, just over one-third (35 percent) rate contaminated drinking water as an extremely serious problem. Similar shares name heroin abuse (35 percent), lack of access to mental health care (33 percent) and obesity (33 percent) as extremely serious problems. About three in ten say diabetes (31 percent), abuse of strong prescription painkillers, sometimes called opioids (28 percent), and heart disease (27 percent) are extremely serious problems, and about a quarter say the same for environmental contamination (26 percent) and lack of access to health care (25 percent). At the bottom of the public’s list are lack of access to affordable healthy food (21 percent) and alcohol abuse (19 percent).
A Closer Look at Substance Abuse
More than one-third of Americans (35 percent) say heroin abuse is an extremely serious problem in the U.S., compared to 28 percent who say the same about abuse of strong prescription painkillers, and less than one in five (19 percent) who say alcohol abuse is an extremely serious problem.
Personal Experience with Prescription Drug Addiction
Prescription drug addiction impacts nearly half of the public on a personal level. Forty-four percent say they personally know someone who has been addicted to prescription painkillers, with about a quarter (26 percent) saying the person they know is an acquaintance, 21 percent saying a close friend, 20 percent saying a family member, and 2 percent saying themselves.
Access to Care
A majority of Americans say that lack of access to care for people with substance abuse issues is a problem (75 percent), including 58 percent who say it is a major problem.
Perceptions of Heroin Abuse Compared to Prescription Painkiller Abuse
Although heroin technically falls into the same opioid family as prescription painkillers, the overall perception of the seriousness of addiction to these two drugs as well as the discrimination faced by those who use them is different. Just over one-third of the public (35 percent) say heroin abuse is an extremely serious problem, while 28 percent say opioid prescription painkiller abuse is. Additionally, about half of the public (52 percent) believe that people who are addicted to heroin face a lot of prejudice and discrimination in this country today, compared to just 38 percent who say people addicted to prescription painkillers do.
Actions to Fight The Increasing Rate of Prescription Painkiller Abuse
The subject of prescription painkiller abuse has gained attention from journalists and policy makers recently, most notably when President Obama announced $1.1 billion in additional funding along-side an array of new measures to fight the opioid addiction.1 Despite this, a majority of the public says the federal government is not doing enough to combat the recent increase in the number of people who are addicted to prescription painkillers (66 percent) or heroin (62 percent). Large shares say other groups aren’t doing enough to combat the problem, including their state governments (67 percent and 61 percent, respectively), doctors who prescribe prescription painkillers (63 percent and 56 percent), and particularly, individuals who use prescription painkillers or heroin (73 percent and 77 percent). Far fewer say police officers are not doing enough to combat painkiller abuse (37 percent) and heroin abuse (36 percent).
The poll also assesses the public’s views on expanding access to a drug called Narcan, or Naloxone, which can prevent people from dying if they are experiencing an overdose of a prescription painkiller or heroin. Currently, some states have made this drug available to adults without a prescription while others restrict the sale of this drug because they think it might encourage the use of illegal drugs. Nearly six in ten Americans (59 percent) think that these drugs should only be allowed with a prescription, while just more than a third (36 percent) think that it should be available without one. The share in favor of access without a prescription is significantly higher among individuals who report a personal experience with prescription painkiller abuse than those without (45 percent vs. 30 percent). Also, Democrats and independents are more likely to favor access without a prescription and Republicans are (40 percent and 41 percent vs. 30 percent).
Policy Efforts to Curb Prescription Painkiller Abuse
The public thinks that a variety of policy efforts would be effective in reducing the abuse of prescription painkillers. Over eight in ten think that increasing pain management training for medical students and doctors (88 percent), increasing access to addiction treatment programs (86 percent), public education and awareness programs (84 percent), increasing research about pain and pain management (83 percent), and monitoring doctors’ prescription painkiller prescribing habits (82 percent) would be at least somewhat effective ways to reduce the number of people abusing prescription painkillers. Smaller shares think that encouraging people who are prescribed painkillers to dispose of any extras once they are no longer medically necessary (63 percent), reducing the social stigma around addiction (60 percent), and putting warning labels on prescription drug bottles that explain the risk of addiction (49 percent) would be at least somewhat effective.
A Closer Look at Mental Health
Personal Impact of Mental Health
A quarter report that a doctor or health professional has told them or another family member living in their household that they have a serious mental health condition, such as depression or anxiety. Furthermore, about two in ten (21 percent) report that there has been a time when they or another family member thought they might need mental health services but did not get them. Individuals say they didn’t get mental health care because they couldn’t afford the cost (13 percent), insurance wouldn’t cover it (12 percent), there were afraid or embarrassed to seek care (10 percent), or they didn’t know where to go to get care (8 percent).
Perceptions About Access to Care for Those with Mental Health Conditions
Nearly nine in ten (87 percent) think that lack of access to care for people with mental health conditions is a problem, including 73 percent who say it is a major problem.
Discrimination and Mental Health Conditions
Substantial shares of the public think that people suffering from mental health conditions experience at least some prejudice and discrimination in this country today. About four in ten (42 percent) say those who suffer from depression face a lot of discrimination, and fewer (32 percent) say the same about those who suffer from anxiety.
Substance Abuse and Mental Health Parity Laws
Policy makers have enacted legal protections aimed at addressing access to care for individuals with substance abuse problems and serious mental health conditions. The Mental Health Parity and Addiction Equity Act, ushered in as one of the many provisions of the Affordable Care Act, legally requires insurance plans to have the same rules for mental health benefits and substance abuse treatment as other medical services.2 However, many Americans remain unaware of these requirements. About four in ten (43 percent) know that health plans must have the same rules for mental health coverage, while an identical share thinks insurance companies can have separate rules and 13 percent don’t know. Fewer (30 percent) are aware that the requirement applies to substance abuse treatment, while over half (53 percent) incorrectly say insurance plans can have separate rules for substance abuse benefits and 15 percent don’t know. Individuals with personal connections to substance abuse and mental health conditions are no more likely than those without personal connections to know about the legal protections around such treatments. | <urn:uuid:e31ddc09-cf56-4a93-82a4-0d842dc74977> | CC-MAIN-2022-33 | https://www.kff.org/report-section/kaiser-health-tracking-poll-april-2016-substance-abuse-and-mental-health/?hsCtaTracking=ee1cc395-7785-46d2-bd19-e574e8b80bd0%7C2a9bd70c-0b54-4b7e-a567-991fed0029fe | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882572161.46/warc/CC-MAIN-20220815054743-20220815084743-00473.warc.gz | en | 0.951136 | 1,820 | 2.734375 | 3 |
In general, pain in the ear accompanied by fever are ear symptoms that require medical attention. This could indicate an infection, which requires a doctor's care. Young children and infants with ear symptoms that include pain, fever, and rash should also be examined by a medical professional. Whenever an injury to the ear has occurred that causes pain and bleeding or disturbances in hearing, immediate medical attention should be sought.
In many cases, minor ear complaints are common and may disappear in a day or two without any medical intervention or treatment. These may include a feeling of stuffiness or minor pressure in the ear. These ear symptoms may be caused by high altitude or allergies. In many cases, discomfort may last a short time, such as a few hours or a day.
Ear injuries can be serious and failure to seek medical attention quickly can cause permanent hearing loss. A foreign object that has pierced the inner ear, for example, may rupture the eardrum and may cause serious complications. Medical attention is necessary for such emergencies. This type of injury is more common in very young children than in adults.
Some ear symptoms involving hearing may develop rapidly with no prior warning. If an individual who has always enjoyed good hearing suddenly develops difficulty in hearing or distortion in sound, this could be a cause for concern. Therefore, it is wise to seek medical attention for any dramatic, sudden changes in hearing.
Ringing in the ears, as well as difficulties with equilibrium are ear symptoms that require medical attention. If accompanied by bouts of dizziness, this could indicate a condition known as tinnitus. Tinnitus refers to a set of symptoms involving the ear and hearing, and can usually be treated through various methods, including medication. Underlying medical conditions may exist.
If a person shows symptoms such as redness, skin scaling, or flakiness and swelling along the side of the ear, this could be allergy related. Medical treatment may include antihistamines. In a worst case scenario, a major skin infection may be the cause, and prescription antibiotics may be needed.
Any time an individual has headache pain and soreness of the outer ear, medical attention is advised. Fluid leaking or discharged from the ear also requires medical attention. These are typical of an inner ear infection that needs to be treated.
Ear pain, along with a snapping sensation or a feeling of popping from the upper jaw most typically requires medical attention as well. These symptoms may be related to a condition known as temporomandibular joint syndrome (TMJ). With this disorder, pain in the jaw, upper or lower teeth, and the ear are common. | <urn:uuid:7759934a-9cf3-48f5-a717-8a6f7898830e> | CC-MAIN-2022-33 | https://www.wisegeek.net/what-ear-symptoms-require-medical-attention.htm | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573104.24/warc/CC-MAIN-20220817183340-20220817213340-00473.warc.gz | en | 0.960217 | 530 | 3.484375 | 3 |
OBJECTIVE: Fibromyalgia is a functional pain disorder in which patients suffer from widespread pain and poor quality of life. Fibromyalgia pain and its impact on quality of life are not effectively managed with current therapeutics. Previously, in a preclinical rat study, we demonstrated that exposure to green light-emitting diodes (GLED) for 8 hours/day for 5 days resulted in antinociception and reversal of thermal and mechanical hypersensitivity associated with models of injury-related pain. Given the safety of GLED and the ease of its use, our objective is to administer GLED as a potential therapy to patients with fibromyalgia. DESIGN: One-way crossover clinical trial. SETTING: United States. METHOD: We enrolled 21 adult patients with fibromyalgia recruited from the University of Arizona chronic pain clinic who were initially exposed to white light-emitting diodes and then were crossed over to GLED for 1 to 2 hours daily for 10 weeks. Data were collected by using paper surveys. RESULTS: When patients were exposed to GLED, but not white light-emitting diodes, they reported a significant reduction in average pain intensity on the 10-point numeric pain scale. Secondary outcomes were assessed by using the EQ-5D-5L survey, Short-Form McGill Pain Questionnaire, and Fibromyalgia Impact Questionnaire and were also significantly improved in patients exposed to GLED. GLED therapy was not associated with any measured side effects in these patients. CONCLUSION: Although the mechanism by which GLED elicits pain reduction is currently being studied, these results supporting its efficacy and safety merit a larger clinical trial.
Bibliographical notePublisher Copyright:
© The Author(s) 2020. Published by Oxford University Press on behalf of the American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: [email protected].
- Complementary Therapy
- Green Light
PubMed: MeSH publication types
- Clinical Trial
- Journal Article
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't | <urn:uuid:5657b2f5-3293-4520-9e81-a3e3ba6afdc7> | CC-MAIN-2022-33 | https://experts.umn.edu/en/publications/green-light-exposure-improves-pain-and-quality-of-life-in-fibromy | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.942792 | 466 | 1.960938 | 2 |
Press release -
University experts wow crowds with their creativity at Maker Faire UK
Northumbria’s students and staff have been awarded for their innovation at this year’s spectacular Maker Faire UK exhibition at the Centre for Life.
More than 10,000 visitors attended the two-day celebration of DIY invention across science, engineering, art, performance and craft, featuring professional and amateur ‘makers’ from around the world. The attractions included robotic dinosaurs, daleks and much more in a huge range of interactive displays, with headliners EepyBird performing a live version of their famous ‘Extreme Diet Coke and Mentos experiment’ in Times Square with spraying geysers of cola 25ft into the air.
Among the ‘makers’ were staff and students from across Northumbria, who helped bring their research and academic excellence to life with a range of interactive displays. This year’s Maker Faire UK was also the first to feature Northumbria’s £3m+ Think Physics project, an initiative led by the University to encourage more young people, especially girls and under-represented groups, to consider studying STEM subjects by opening their minds to science from Early Years onwards.
Think Physics enjoyed an award-winning debut at the event after being awarded a Maker of Merit ribbon for creating one of the best and most innovative exhibits with its Light Box wall.
Think Physics Director, Dr Carol Davenport, said: “The Think Physics team were absolutely delighted with our first appearance at Maker Faire UK. Our two installations provoked wonder and sparked conversations.
“We're particularly pleased that our light box wall was awarded a Maker of Merit ribbon by the organisers. The wall was an ever-changing sculpture of light and shadow created by visitors, young and old, to the show, and was always busy with making – encompassing the spirit of both Think Physics and Maker Faire UK.”
Northumbria’s ongoing support for this family friendly weekend of invention and creativity further demonstrates the University’s commitment to driving world-class research and teaching across STEM disciplines following the launch of Think Physics and its co-funded £6.7 million investment in new STEM facilities.
Lucy Winskell OBE, Northumbria’s Pro Vice-Chancellor for Business and Engagement, said: “Northumbria University supports Maker Faire UK because it makes a difference and helps inspire young people to have a go and see what they can do. That’s exactly what we need if we want to plug the skills gap and address the gender imbalance in STEM. It is vitally important we encourage the next generation to see the exciting range of careers available to them in this area.”
Staff from Engineering and Environment and Health and Life Sciences courses also had stands at the event. These included exhibits from Northumbria’s Physics and Electrical Engineering department led by Head of Department Dr Richard Binns. He said: “The department provided a stand at the event as a way of promoting some aspects of electrical and electronic engineering. We highlighted the John Adams hot wires kits of basic electronics which attracted ,any children to the stand with the motor experiments sending spinning disks flying off into the venue. It quickly became a game of how high they could be propelled and how the circuit could be modified to have more power.
“A simple robot was also on show based on Lego Mindstorms and we had a number of exhibits from our final year students demonstrating their project work which proved exciting, especially as the students could then help and play with the kits themselves. Projects from students included a Telepresence Robot inspired by The Big Bang Theory, a Camera Hyperlasping rig, and a Potentiometer test system for use in industry. We also had a number of research demonstrations based on visible light communications. We’re already looking forward to next year’s event.”
Northumbria offers a range of courses across the STEM disciplines. To find out more, register for Northumbria’s Open Days on Friday 26 and Saturday 27 June at www.northumbria.ac.uk/openday
Banner image coutesy of EepyBird.com
Northumbria is a research-rich, business-focussed, professional university with a global reputation for academic excellence. To find out more about our courses go towww.northumbria.ac.uk | <urn:uuid:09b39a60-0ab9-49ba-8d19-38c39e5a5b31> | CC-MAIN-2022-33 | https://newsroom.northumbria.ac.uk/pressreleases/university-experts-wow-crowds-with-their-creativity-at-maker-faire-uk-1194726 | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.957019 | 924 | 1.914063 | 2 |
If you’re thinking about getting a dog, you want to make sure you are ready. There are sacrifices in time and money you will have to make and it’s crucial that you consider what it will mean to be responsible for a new furry friend.
Before you start looking
There are a number of considerations you should think through before getting a dog. After all, you want to give a dog a happy forever home and not regret your decision.
- Financial: Even just in their upkeep, dogs can get expensive. Between vet bills, food, and other amenities the annual cost for caring for a dog, according to the ASPCA, is about $420 for a small dog, $620 for a medium dog and $780 for a large dog. The cost for a puppy can be more and they can ruin items in your home. Consider if you want a puppy or would rather adopt a more adult dog.
- Breed compatibility: Dog breeds are ever expanding and while all dogs are different, their breed does determine certain kinds of behaviors and needs. Some dogs require more outdoor space and some are comfortable with a small room, some are better with other animals and children and others are less so. Size of the dog doesn’t necessarily translate to one or the other. There are small dogs that need space to run and large dogs that are very happy laying around in one room. If you need help in determining the best breed for you the American Kennel Club has an online Dog Breed Selector that poses useful questions. Honest answers to things like your activity level, comfortability with barking noise, and how much shedding will irritate you, will make your selection more accurate and lead to a better match for your lifestyle.
- Take your time: Your instinct may be to jump into getting a new dog, but taking it slow will pay dividends. It’s hard to say no when you see the eyes of a would-be companion (in fact, they evolved that look, just to get to your softer side) but you want to make sure you can give that dog a good life.
- Ready to go — think adopt first: There are many shelters with wonderful dogs waiting to be placed in new homes, and there are a number of benefits to adopting including some free or reduced medical procedures like spaying or neutering and follow up on conditions like knee dysplasia.
Prepare your space
Once you’ve picked out the pet of your dreams, there are a number of preparations for a new dog you have to make right away.
- Get your house in order: You’ll want to put away anything that can be consumed or chewed up by a new dog. Get food away from where your dog might get it and protect any knick-knacks from over eager tails.
- Poison control: Be careful of any poisonous plants or products that might be in the area where a dog can reach. That includes looking at your outdoor plants and what you use for things like fertilizer, weed killer, and to melt ice. Pet friendly versions of these products are available. There are also a number of foods that make dogs sick like chocolate, grapes, and onions. Do a little research and try not to feed your dog people food in general.
- Get a crate: Crate training is great for new dogs. While it might seem cruel to you, a crate is a comfort to dogs, giving them their own private space. Make sure the crate you get is commensurate with the size dog you are bringing home. One too large and the dog may use part of it for a bathroom, too small and you risk it being too cramped.
- Get a dog bed: Dogs generally love having a place to be. So similar to the lesson of the crate, try introducing the dog to a bed that they will like in an appropriate size.
- Food: Do some research to discover what the best kind of food is for your dog. If it is not what they are used to, remember to switch over their food slowly by mixing a little of what you are going to feed them in with what they are used to eating.
- Bowls: Obviously you’ll need bowls for food and water – metal is best because it doesn’t break easily and is easy to keep clean. Try to get something that will resist sliding across the floor.
- Toys: Most dogs enjoy chew toys or pull toys that keep them active. Toys where you can insert treats, like kongs, can be particularly fun because they involve a food incentive.
- Leash, collar & harness: While there is some consideration as to whether a harness is necessary for a dog, walking with just a collar (especially for small dogs who are not leash trained) can cause neck injury.
- Gates: If you want to keep your dog in a certain part of the house (even if just part of the time) it’s useful to get some pet gates. However, do some research to see if your new dog will be stopped by the gate your purchase. Some dogs climb easily and some larger dogs can jump higher than you might think.
Prepare your dog
Bringing your dog home is exciting, but you want to make sure that your dog is ready for the big world.
- Get your dog spayed or neutered: This is important so the population of animals does not get out of control. Plus it will make being a pet owner easier. Many places have a law against having a dog that is not fixed anyway.
- Consider pet insurance: Costs associated with vet bills can be large, it often makes good sense to get pet insurance. There are good plans that cover vet visits and vaccinations as well as all kinds of potential accidents.
- Consider microchipping: It’s a great way to keep track of animals and make sure you can find them if they go missing. Microchipping is not expensive and might be the best decision you ever make regarding your pup.
- Learn where to socialize: Dogs are pack animals and generally love to get together. Seek out dog friendly resources in your area with BarkHappy and see how they quickly learn to connect with you and with other animals in the neighborhood.
Seem a little overwhelming? This is just a solid beginning when it comes to getting your dog ready for your new life together. Check this site for some useful checklists to look over that will help you keep the transition to dog owner under control. Take it slow, do your research, and don’t worry – it will all be worth it when you get greeted by a sweet friend at the door every day.
Sarah is a Content and PR manager at Your Best Digs. She’s passionate about evaluating everyday home products to help customers save time and money. When she’s not putting a product’s promise to the test, you’ll find her hiking a local trail or collecting stamps in her passport. | <urn:uuid:c87e628b-2796-4ac9-9b6e-9aa31063a7f4> | CC-MAIN-2022-33 | https://barkhappy.com/be-prepared-what-to-do-when-getting-a-new-dog/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573540.20/warc/CC-MAIN-20220819005802-20220819035802-00473.warc.gz | en | 0.957133 | 1,432 | 1.6875 | 2 |
In partnership with the Westernline School District, Delta Foundation will provide the 21st Century (Science, Technology, Engineering, Agriculture and Math) after school and summer academic and enrichment program, encompassing; entrepreneurial: cultural; financial; empowerment activities and skills to students in the Westernline School District.
21st Century program is about making learning fun. Every activity is hands on all the students get a chance to participate. We have fun, empowering activities such as: Martial Arts, which will teach the children discipline, respect, memorization skills, goal setting, and give 100% effort. Robotics, which will show the importance of planning, time management, team build, physics, and how to accept failure and turn it into success. Wood shop/Construction, which the show the importance of math and geometry. These are just a few of our many exciting activities.
Program Coordinator | Mashondia Wells
Phone | (662) 335-5291 | <urn:uuid:16d8b101-f147-4db5-adc3-d9dea48a76b5> | CC-MAIN-2022-33 | https://www.deltafoundationms.org/21st-century/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573540.20/warc/CC-MAIN-20220819005802-20220819035802-00473.warc.gz | en | 0.92566 | 200 | 2.171875 | 2 |
UM signs Amnesty manifesto ‘Let's talk about Yes’
On 3 November, Maastricht University (UM) signed Amnesty International's manifesto ‘Let's talk about Yes’. With this, UM will intensify its activities against sexual violence. In doing so, UM will explicitly seek out cooperation with parties that have their own expertise, responsibilities and mandate in this area, such as the Municipal Health Services (GGD)/Sexual Assault Center (CSG), the police and the municipality.
UM itself will also take additional actions along the lines of the Amnesty manifesto:
- All students must be able to follow workshops that have been shown to reduce sexual violence, such as bystander training.
- Provide clear and continuous communication about help and reporting facilities, and about our own and the legal codes (of conduct).
- Train staff members who are in contact with students, so they know how to deal with signals or reports of sexual violence.
- Fine-tune the reporting and complaints procedure so that it is crystal clear and detailed/comprehensive.
- Implement specific training for staff members who play a role in the reporting and complaints procedure.
- UM will involve students in the implementation of the above actions.
Research confirms the need for action
The manifesto is a response to research commissioned by Amnesty into sexual violence among students. This research shows that many students experience sexual violence. Research conducted by UM among its own student population confirms these findings.
Last summer, Amnesty International presented the results of research on sexual violence among Dutch students. During their time as a student, 11% of female students and 1% of male students reported experiencing penetration without consent. Of these students, 67% indicated having psychological, sexual, physical or social problems as a result. In addition, a majority of students indicated that they do not know where they can find information or help within their educational institution if sexual violence occurs.
Last year, UM conducted research among its own students regarding sexual violence. The surveys were set up differently and, unlike the Amnesty survey, the UM survey asked students the questions in English. The UM study was also more extensive; several forms of sexual violence were included in the study and sexual harassment was also looked at.
With these differences in mind, the researchers conclude that their survey among UM students still broadly supports the results of the Amnesty study. Of the UM students who were surveyed, 9.8% indicated that they had experienced sexual violence (in the form of penetration without consent). More than half of these students knew the perpetrator from within UM. This is not surprising for the researchers; other studies on sexual violence have shown that perpetrators are often acquaintances of their victims.
Almost three quarters of the group that experienced some form of sexual violence indicated that they also experienced negative consequences as a result. And although many UM students know of one or more 'UM help desks' where they can go, they often lack the overview to make a specific report or to get help. These results are also comparable to the results of the Amnesty survey. And they are more than enough reason to provide additional clarity to students about how the university can also offer help, together with other providers of medical, psychological and legal support. | <urn:uuid:5ea1f973-4dd9-49e8-b95d-82230ed61727> | CC-MAIN-2022-33 | https://www.maastrichtuniversity.nl/news/um-signs-amnesty-manifesto-%E2%80%98lets-talk-about-yes%E2%80%99 | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.970764 | 651 | 1.882813 | 2 |
London: Elek Books, 1956. Presumed First Edition, First printing. Hardcover. , 241, pages. The contents include: Hotel at Arrochar Christening, Trial and Error, By Suez to Ceylon, Tragedy on Patrol, Minelay; Ramming; Depth-Charged; Across the Equator; Crashing the Sunda Strait; Silent Invasion; The Strain Begins to tell; Royal Marine Landing; Australian Interlude; Gun Blood; Bombed into the Mud; The War Ends. Postscript--Submarines of the future, Appendix I--Awards, and Appendix II--Glossary of Terms. This book is the direct sequel to the author's brilliant and successful submarine story, Unbroken. Lieutenant Commander Alastair Campbell Gillespie Mars, DSO, DSC and Bar (1 January 1915 – 12 March 1985) was a Royal Navy World War II submarine commander. In 1952 he was court martialled and dismissed from the service under controversial circumstances and pursued a career as an author. In November 1941 Mars was appointed as commanding officer of HMS Unbroken, which he served on until June 1943 on operations in the Mediterranean. From August 1943 until December 1943 he was a staff officer at HMS Dolphin submarine base in Portsmouth. In December he was placed in command of HMS Thule in the Far East, remaining there until November 1945. Mars was arrested and court martialled for insubordination and absence without leave, which resulted in his dismissal from the Navy in June 1952. The controversy over his dismissal was the subject of a parliamentary question the following month, when the future prime minister James Callaghan asked the then First Lord of the Admiralty whether Mars would receive his pension. This book covers the period from about half-way through the War when the author was given command of the submarine HMS Thule and sent East, sailing on patrols out of Freemantle against Japanese shipping, until the end of the War. HMS Thule was a British submarine of the third group of the T class. She was built as P325 at Devonport Dockyard, and launched on 22 October 1942. So far she has been the only ship of the Royal Navy to bear the name Thule, after Thule, the mythological name for a northern island. Thule served in the Far East for much of her wartime career, where she sank thirteen junks, two lighters and five sampans with gunfire in the Strait of Malacca in a twelve-day period between 17 December 1944 to 29 December 1944. She also attacked a submarine, probably the Japanese submarine Ro-113 and believed she had sunk it, but Thule's torpedoes exploded prematurely and the submarine escaped unharmed. She went on to sink a further five sailing vessels and three coasters, as well as laying a number of mines. She survived the war and continued in service with the Navy. In May 1951, Thule was sent to Canada to train with the Royal Canadian Navy. On 18 November 1960, Thule, a member of the 5th Submarine Squadron, was taking part in an anti-submarine exercise off Portland Bill, when she was accidentally rammed by the Royal Fleet Auxiliary tanker Black Ranger when at periscope depth. Thule's snort was broken, one of her periscopes was bent and her casing was damaged. The submarine was scrapped at Thos. W. Ward, Inverkeithing on 14 September 1962.
Her first commander, Alastair Mars, wrote HMS Thule Intercepts, about her operations from commissioning in Scotland to the end of the war in Australia. Condition: Good / Good.
Keywords: H.M.S. Thule, P325, Submarine, T Class, Royal Marines, Naval Operations, Pacific Theater, Freemantle, Japanese Shipping, strait of Malacca, Torpedo, Minelaying, Ro-113 | <urn:uuid:060ad3da-794b-4b11-867a-06a481b6db7a> | CC-MAIN-2022-33 | https://www.groundzerobooksltd.com/pages/books/84108/alastair-mars/h-m-s-thule-intercepts | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573540.20/warc/CC-MAIN-20220819005802-20220819035802-00473.warc.gz | en | 0.968672 | 816 | 1.828125 | 2 |
The School of Architecture at the University of Illinois at Urbana-Champaign, in partnership with Escola Tècnica Superior d'Arquitectura del Vallès (ETSAV), offers the a unique study abroad opportunity in Sant Cugat, Barcelona, Spain. Largely modeled after the School's 44-year long successful experience in Versailles (France), the Illinois Architecture Study Abroad Program in Barcelona el Valles (IASAP-BV) at the ETSAV began Fall 2014. This yearlong overseas educational experience is now open to both junior and senior students of the Illinois School of Architecture who spend the year living, studying and learning in the historically and architectural significant cities of Sant Cugat, where the ETSAV is located, and Barcelona (the former located and easy 15-minute train ride from Catalunya's capital).
This program fosters inter-institutional activities, joint courses and workshops, and numerous curricular and extracurricular activities that will enrich the experience both at the pedagogic and personal levels. Heralded by the National Architecture Accreditation Board (NAAB) as "one of the salient strengths of the School" and "likely the best architecture study abroad program in the country" it affords the students the once-in-a-lifetime opportunity to discover the culture and architecture of cities, regions, and countries throughout the European continent.
Course of Study
The program of study in Barcelona includes courses in architectural design, history, and structures (all academically equivalent to those offered in Urbana) and additional course activities with seminar and independent study credit. Classroom activities are supplemented by guest lectures, field trips, and directed independent study-travel.
In the design studios, students develop sensitivity to context through projects sited in European settings. Studio workspaces are assigned in the ETSAV's talleres, alongside and under the same conditions of use of students at the host school. Architectural history courses include visits to exemplary historic and contemporary buildings. Structures courses are equivalent to those offered in Urbana-Champaign.
Additional courses include sketching assignments, seminars (usually focusing on the European experience) and support language courses. The program aims also at establishing close collaboration with the Spanish school adding to the benefit of our students.
Each semester the academic calendar incorporates periods in which participants have the opportunity to travel and study across Europe on an independent basis. During these study-travel times students will be required to record their experiences in a journal to be filled with sketches and notes of the sites visited. One of the most rewarding learning activities, sketching helps students understand architecture through personal experience and on-site studying, improving their ability to conceptualize architectural ideas and communicate them on paper. | <urn:uuid:1a9b8f9b-7a9f-4ac1-af80-5b5ce753642c> | CC-MAIN-2022-33 | https://app.studyabroad.illinois.edu/index.cfm?FuseAction=Programs.ViewProgram&Program_ID=11752 | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573540.20/warc/CC-MAIN-20220819005802-20220819035802-00473.warc.gz | en | 0.933445 | 572 | 1.546875 | 2 |
In computer, data recovery is a procedure of recovering (retrieving) inaccessible, lost, corrupt, damaged or formatting data from external storage devices, computers or other computers. Data recovery can be done through several ways. The most common method is to check if the data is still available using some special software. This is called “checksum recovery”. If the data is available, the hard drive can be read using this software. This will ensure that your data is still intact and safe.
Apart from checking if data is still available using this software, you can also check whether they are physically damaged or not. Physical damage is usually caused due to physical shock or impact. logical bad sectors in some of the external hard drives can also cause logical bad sectors in the storage devices. When this happens, the data files on these drives can become corrupted or inaccessible. Data recovery can then help you to restore your data files from these physical drives.
Other methods of data recovery software include ‘live cd’ programs. These programs are installed on your computer and it enables you to boot up from a CD when your hard disk is not working properly. Live CDs do not require installation of software as they come with an integrated operating system and all the software required by you is installed already. This software is similar to the installed program, just that it comes on the CD instead of an actual hard disk. After you install the software, it boots up and searches for lost partitions, deleted files or any other file loss.
Another data recovery software method is to create a backup disk image. You can make a backup disk image of your entire hard drive. When you backup the disk image, you can easily recover data files even when your storage devices are broken. The open-source CDR software can also be used to create a disk image.
You can also use ‘dde’ command in Windows to recover data files. When the logical failure occurs, a DDE will prompt you to select a recovery mode. If your storage devices have a Secure USB port, a DDE can access the storage device from the USB port without using a PC. You can also perform a DDE without any other storage device by connecting the data recovery software to a host computer.
Physical Damage Can Cause Physical Failure physical damage is also one of the major reasons why data recovery becomes complicated. When data recovery becomes complex due to physical damage, you cannot just pull out the storage media and use it again. If the damage is far too extensive, it will be impossible to retrieve important data. Even if you manage to pull out the media and restart the system, the recovered data may be stored on corrupt storage media. Physical damage comes in different forms such as logical damage caused due to accidental deletion or file system corruption, physical damage caused due to fire or flood, physical damage caused due to sabotage, and so on.
How to Perform Mac Data Recovery If you are planning to perform data recovery on Mac OSX operating system, you can use a disk cloning software program to clone your hard disks. The disk cloning software programs are available for both MAC and PCs. They are a little bit different from the standard disk imaging software. With the standard disk imaging software, you can only clone one disk at a time. But with disk cloning programs, you can clone multiple disks. You can even copy data to different disks at a time.
One of the main advantages of these programs is that they allow you to copy data to regular hard disks and then copy the data to USB flash drives. This helps you to easily recover the data from all types of storage devices including, Mac Os, iPhones, computers, laptops and other storage devices with USBs. If you want to perform data recovery for Mac, the best solution is to invest in the right disk cloning software program. For more information on how to backup your data on mac x usb drives, visit the website below. | <urn:uuid:87953bb8-df4c-4e62-92e4-ca993a77e2b8> | CC-MAIN-2022-33 | https://dr-it.co.uk/data-recovery-for-mac-os-x-usb-drives/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.916096 | 794 | 3.34375 | 3 |
When you need help from emergency services, you typically don’t need it in 15 minutes: you need it now.
To that end, Capital City Fire/Rescue is working under the auspices of a larger state program to push access to Narcan, which helps counteract overdoses from opioids, out to the community.
“All of our transport rigs, our engines, and even our (Community Assistance Response and Emergency Services) vehicle are going to carrying it soon,” said Andrew Pantiskas, CCFR’s emergency medical services officer, in a phone interview. “We’re giving them the ability to not have to go in for that kit, and improving patient care overall.”
Community distribution, scheduled to begin next month, is part of Project Hope, a state Department of Health and Social Services program to help combat opioid overdoses in the community, Pantiskas said. The program will distribute Narcan kits to individuals that are having an opioid overdose, so that themselves or someone around is having an opioid overdose in the future, they have the response at hand.
“Basically, what we’re looking at is extending our emergency response agencies’ reach with their kits,” Pantiskas said. “We would be helping get more Narcan whether or not they go to the hospital.”
Decentralization of health care and pushing community and telehealth care has been a major priority of the state’s, especially since the beginning of the pandemic saw jam-packed emergency rooms across the state.
“We want to have a wider net of people,” said Dr. Quigley Peterson, CCFR-sponsored physician at Bartlett Regional Hospital. “We want to help keep people from dying. I think that’s really important. When this started, people would say ‘you’re just facilitating their addiction.’”
Pantiskas said CCFR is getting 100 doses of Narcan to begin. Narcan use during calls for all of CCFR each year ranges in the 30-50 range, Pantiskas said.
“I figure that’s a good round number. We’re going to put five kits on each rig we respond with,” Pantiskas said. “I can see us probably giving this out once, maybe twice a week in Juneau.”
Statewide, the program delivered more than 12,000 across Alaska so far, according to the program website.
“This is a way the state can get it to people who need it,” Pantiskas said. “It’ll also be really good for parents who have pain meds in the house.”
An opiate overdose can result in a person’s body stopping an unconscious function such as breathing, Peterson said. The Narcan comes in a nasal applicator to rapidly reverse the overdose, Pantiskas said.
“It’s made so the public can literally put it in someone’s nose and squeeze. Even a kid could do it,” Pantiskas said. “It blocks the receptors that would be stimulated by the opiate, the morphine or the heroin.”
Pantiskas said opiate uses– and overdoses– are distributed, rather than targeting any one particular demographic.
“I would say 2020 had maybe a slight increase. 2021, we started getting back on the right track,” Pantiskas said. “It’s very spread out. You can’t stereotype it too much. Sometimes it’s kids, sometimes it’s adults, sometimes it’s the homeless population. There’s not one set population I could say is doing it.”
CCFR Narcan Use by Year
2018- 46 times
2019- 48 times
2020- 46 times
2021- 37 times
Incidents involving any type of drugs | <urn:uuid:4310ea59-eeb3-4d59-bb72-886da9deb9e7> | CC-MAIN-2022-33 | https://www.juneauempire.com/news/ccfr-starts-program-to-push-narcan-out-to-residents/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573104.24/warc/CC-MAIN-20220817183340-20220817213340-00473.warc.gz | en | 0.936234 | 848 | 1.960938 | 2 |
From its modest beginnings, snow skiing has grown into an important part of the economy and culture of western North Carolina. Skiing on snow has been practiced in northern Europe for over 4,000 years but did not become a recreational pursuit until the late nineteenth century. The two main types of competitive skiing include Alpine, or downhill, skiing and Nordic, or cross-country, skiing. Exactly when snow skiing was first practiced in North Carolina is unknown. A photograph appearing in North Carolina: A Guide to the Old North State, published by the Works Progress Administration in 1939, shows a group of skiers on an unnamed snow-covered hill in Banner Elk. An article in The State magazine claims that the first organized ski club in the South was organized in 1940 at Lees-McRae College. Certainly by the 1950s, snow skiing was becoming a popular pastime in western North Carolina. Skiers were engaging in Nordic skiing on Clingman's Dome in the Great Smoky Mountains National Park, while downhill skiers at Roan Mountain were discussing erecting a tow rope as early as 1951. In addition, there were people skiing along the slopes of Mount Mitchell, and several individuals there supported an effort to get the state to develop a lodge and snow skiing facilities.
Organized commercial ski operations began in North Carolina in December 1961, when Tom Alexander opened the Cataloochee Ski Slopes in a pasture on a hillside behind his ranch in Haywood County. The name was soon changed to Cataloochee Ranch and Ski Area. Alexander utilized snow-making equipment, at the time in its early stages of development, to produce snow on his pasture. For his efforts, Alexander is often referred to as the "Father of Southern Skiing."
At Blowing Rock, Bill Thalheimer led an effort to create the state's first commercial ski operations, but bad weather hampered construction, and it was not until the spring of 1962 that his slopes opened to the public. The Blowing Rock Ski Lodge (modern-day Appalachian Ski Mountain) between Boone and Blowing Rock featured three slopes serviced with tow ropes and the first T-bar type lift used in North Carolina. This also was the first facility in the state equipped with lights for night skiing.
In 1964 Grover, Harry, and Spencer Robbins, brothers active in development efforts in western North Carolina, opened two small ski slopes at Hound Ears Club near Boone. Though small in scale, their operation drew rave reviews. Other small-scale resorts opened in the mid-1960s, including Sapphire Valley near Cashiers and High Meadows near Roaring Gap.
Efforts to create the ski complex that became Seven Devils began in 1964. Six investors from Winston-Salem acquired 1,288 acres in Avery and Watauga Counties. Seven Devils finally began snow skiing operations in the spring of 1967. One of the most influential individuals in the snow skiing enterprises in western North Carolina was Tom Brigham, a dentist from Birmingham, Ala., whose goal was to create a ski resort in the South along the lines of the famous New England resorts. Brigham began searching for a location for his southern ski resort in the late 1950s. After studying numerous sites, he settled on the Banner Elk area and began purchasing land at Beech Mountain in 1961. By 1962 trails had been cut, but an economic downturn dried up financing.
The project advanced little until 1966, when Brigham joined forces with the Robbins brothers of Hound Ears fame. They set out to build what was dubbed the "Disneyland of Southern Skiing." By December of 1967, Beech Mountain was open, deemed to have the highest skiing in the East and featuring the region's first cabin-type gondola lifts. Brigham moved on in 1968 to begin development of another ski area, Sugar Mountain. Located between Linville and Banner Elk, this 3,000-acre resort opened in the fall of 1969. Major features for the site included the distinction of having the "greatest vertical drop south of New England" (1,200 feet).
"The Ski Slopes are Swinging," The State (15 Jan. 1970).
Bill Wright, "Amazing Rise of the Tar Heel Snowbird," The State (15 Jan. 1968).
Beech Mountain, 2010. Image courtesy of Flickr user Mike Sagmeister. Available from https://www.flickr.com/photos/mikesagmeister/4394037000/ (accessed September 13, 2012).
1 January 2006 | Hairr, John | <urn:uuid:7ee4a1ee-d6ce-46aa-8cf1-9d4a544033bb> | CC-MAIN-2022-33 | https://dev.ncpedia.org/skiing | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.967494 | 928 | 3.21875 | 3 |
You may be familiar with the classic HC-SR04 distance sensor, it is great for providing non-contact distance readings from 2cm to 400cm. The SparkFun Qwiic Ultrasonic Distance Sensor improves on the classic by adding a pair of Qwiic connectors to it, so now you can communicate over I2C and daisy chain any other Qwiic product of your choosing.
If you prefer to bypass the Qwiic connector and I2C you can also access the VCC, Trigger, Echo, and Ground pins broken out on the edge of the board. Please be aware that this ultrasonic sensor comes uncalibrated and you will need to manipulate the raw output for your specific application.
The SparkFun Qwiic Connect System is an ecosystem of I2C sensors, actuators, shields and cables that make prototyping faster and less prone to error. All Qwiic-enabled boards use a common 1mm pitch, 4-pin JST connector. This reduces the amount of required PCB space, and polarized connections mean you can’t hook it up wrong.
- 1x Ultrasonic Distance Sensor - HC-SR04
- 1x Right-Angle Header - 4-pin
- Operating Voltage 3.3V
- Detecting Angle: 15 degrees
- Sensor range: 2cm to 400cm
- Accuracy: 3mm
- MCU on board: STM8L051
- Default I2C Address: 0x00
- Dimensions: 21.5 x 45.5mm
- Weight 9.2g
Payment & Accreditations
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information. | <urn:uuid:7ce8b7f8-b3e4-49fb-b766-5d31f7f353a5> | CC-MAIN-2022-33 | https://thepihut.com/collections/sparkfun/products/sparkfun-qwiic-ultrasonic-distance-sensor-hc-sr04 | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.822796 | 369 | 1.625 | 2 |
Prospects look positive compared with 2014, when only 107MW of new capacity came online, pushing the country's total to 8.66GW. That was well below the 433MW commissioned in 2013 and particularly bad when compared with the average 1GW installed annually in 2010-2012. All of Italy's wind capacity is onshore, and this is likely to remain so for the near future.
A total of 365MW of onshore wind projects were assigned a FIT in Italy's last auction carried out in 2014 under an old market framework. Investors now await legislation specifying how much capacity will be assigned annually in 2016-2020 through future auctions.
The government has pledged to make corrections to the system to increase the likelihood of projects assigned the tariff being built, while market participants would also welcome a simplification of the currently complex repowering process.
Major support for further Italian wind development is seen as unlikely, however, partly because the country has already met its 2020 target for renewable-energy power generation. With limited growth prospects, market players are focusing on maximising the efficiency of operating assets. | <urn:uuid:fca4ce65-feb2-4c75-9e1e-a7a693598b7f> | CC-MAIN-2022-33 | https://www.windpowermonthly.com/article/1340369/market-status-italy-auction-process-needs-clarifying | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.964027 | 221 | 2.171875 | 2 |
Value Chain Expertise
Bananas are the most popular fruit in the world. The banana is not a tree or a palm, but a member of the lily family and grows up to 15 metres. Their origin is placed in Southeast Asia, in the jungles of Malaysia, Indonesia or Philippines, where many varieties of wild bananas still grow today.
Worldwide, annual production of all types of citrus fruit totalled some 133 million tonnes in 2017, according to FAOSTAT crop data. In the past 30 years the World crop has grown more than 2.4x. More than 90% of World fresh fruit citrus production is consumed in the country of production.
Today derivatives of the cocoa bean are found in confectionery with a global sales value that is expected to be in the order of $120bn in 2014. The chocolate confectionery sector has produced brands that are instantly recognised across the globe: Nestlé, Mars, Cadbury, Ferrero, Lindt & Sprüngli and many more.
Historically produced for the manufacture of coconut oil (from copra, which is dried coconut flesh) and desiccated coconut, the coconut is a ubiquitous palm species (Cocos nucifera) well distributed across the tropical belt. Cultivations of the palms extend to perhaps more than 12 million hectares with annual production estimated at some 75 billion nuts (62m mt).
The cultivation of the Date Palm is inextricably bound up in the history of the peoples occupying the Indus Valley in modern day Pakistan, and the countries of the Arabian Gulf, from circa 6,000 BC. Archaeologists have found evidence of its production 8,000 years ago in Neolithic sites in Syria and Egypt, and its prominence in Middle Eastern culture is still widely to be observed.
We estimate that in excess of 23 million hectares of land are planted in oil palm across the tropical belt for the commercial production of palm oil. Another 4 million hectares of wild, feral or informal stands may additionally exist in West Africa.
Agronomy Capital Advisors Ltd was established to provide advisory services for businesses and investors in the agriculture supply chain. We have a particular focus on the large scale tropical tree crop sector and the associated value chain, spanning oil palm, natural rubber, cocoa, bananas, coconuts, mangoes and citrus. Agronomy Capital Advisors was founded by Doug Hawkins in 2009. Agronomy Capital Advisors has developed to become an internationally recognised advisory firm for agri-value chain analysis, market research, agribusiness valuations, due diligence, and funding strategies. Our clients include listed companies, private enterprises, investment institutions, crop science companies, university foundations, family offices and global food manufacturers.
A global pool of expert resources across the agribusiness value chain
An extensive network of contacts across the global agribusiness value chain
More than 40 years of capital markets experience relating to debt and equity capital financing
News & Publications
Agronomy Capital Advisors is one amongst a number of parties sponsoring Andrew Tillery, (Chairman of Dekel Oil Plc and CIO of Palladium London) who has agreed to undertake the The Thames Path Ultra Challenge, a 100 km run from the London borough of Hammersmith & Fulham to Henley in Oxfordshire, on Saturday 7th September, to raise money for Macmillan Nurses – a UK charity registered for cancer relief.
At an estimated US$3bn-$4bn, the global annual trade in Dates, is small by comparison to Bananas ($20bn), Cocoa ($10bn, $120bn cocoa derived consumer goods) or Coconuts & Coconut products ($12bn-$15bn). However, the cultural and demographic shifts resulting from globalisation, have prompted robust growth in demand for Dates and Date products outside the traditional markets of North Africa, Middle East and South Asia.
Worlds Apart explores how surging demand for modern coconut consumer products, contrasts with a structurally constrained upstream producer sector which comprises some of the poorest smallholder farmers on the planet, raising questions about the sustainability of traditional coconut production.
In theming the 2018 biennial conference ‘A World Without Chocolate’, the AoC sought to draw attention to the personal importance of chocolate to so many people around the world, whether as a ‘pick-me-up’, a treat or a small but luxurious indulgence or, perhaps too, as a livelihood, and the theme also sought to highlight the importance of chocolate as a significant value chain in the global economy. | <urn:uuid:ff26224d-580d-4057-a495-a9496a9f4ba4> | CC-MAIN-2022-33 | http://www.agronomycapitaladvisors.com/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573104.24/warc/CC-MAIN-20220817183340-20220817213340-00473.warc.gz | en | 0.926013 | 961 | 2.671875 | 3 |
Proposed amendments to the draft legislation for non-resident registration requirements were released in April 2021. They include, among others:
- a safe harbor for platform operators limiting liability for failure to collect and remit tax if the platform operator reasonably relied on information from a third-party supplier;
- a clarification providing that sellers registered under the simplified process will be eligible to deduct amounts for bad debts;
- a clarification providing that supplies of digital products or services that are zero-rated are not included in the calculation of the $30,000 threshold amount for determining if a person is required to be registered under the simplified framework;
- an additional provision stating that the tax authority may register a person that it believes should be registered under the simplified framework; and
- an additional provision providing that, when an affected business or platform operator shows reasonable measures have been taken but it is unable to meet the new obligations for operational reasons, the tax authority will take a practical approach to compliance and exercise discretion in administering the requirements during a 12 month period beginning July 1, 2021.
What is the Canadian GST/HST?
Two types of sales taxes are levied in Canada – provincial sales taxes and the goods and services tax (GST)/harmonized sales tax (HST). Provincial sales taxes are collected in the provinces of British Columbia, Manitoba, Quebec and Saskatchewan, where the tax bases and rates vary. The GST applies nationally, and the following provinces harmonized their provincial sales taxes with the GST to implement the HST: New Brunswick, Newfoundland and Labrador, Nova Scotia, Ontario, and Prince Edward Island. Generally, the HST operates the same and has the same tax base as the GST. The GST rate in provinces without an HST is 5%, and the GST/HST combined rates are 15%, except in Ontario where the rate is 13%.
The GST/HST is a value-added tax, which operates on an input/output system. When a taxpayer buys goods or services, it pays GST/HST – this is the input tax. When the same taxpayer sells its product, it collects GST/HST from buyers – this is the output tax. The taxpayer deducts the input tax from the output tax and remits the difference to the tax authority.
What Sales are Subject to GST/HST?
The GST/HST is a broad-based consumption tax. Most sales of property and services are subject to the GST/HST, including sales and leases of commercial real property, sales of services, and electronic commerce transactions (e.g., sales of software, SaaS and digital products). There are rules for sourcing sales that vary depending on the nature and characterization of sale. Generally, sales of tangible personal property are sourced to the location where the purchaser takes delivery of the goods, sales of intangible personal property are sourced to the location where the rights may be used, and sales of services are generally sourced to where the seller obtains an address in Canada of the recipient. Since these rules differ, it is important to properly characterize a transaction to determine where it should be sourced.
Current GST/HST Registration Requirements
Generally, every business that makes a sale subject to GST/HST in Canada in the course of a commercial activity must register for GST/HST purposes, unless the business is a “small supplier” or a non-resident without a permanent establishment that does not engage in any business in Canada.
A “small supplier” is generally a business with $30,000 (CAD) or less in worldwide revenue from taxable sales in a calendar quarter and for the prior four consecutive calendar quarters. (Different thresholds apply to charities.) Importantly, the revenue of certain affiliates is included in the threshold calculation. Sales of business goodwill, financial services and capital assets are not included in the calculation.
The determination of Canadian residency differs for individuals, corporations and partnerships, and a non-resident business may still be required to register for GST/HST purposes if it has a “permanent establishment” in Canada. Notwithstanding residency, a seller may also have a registration requirement if it is carrying on business in Canada. The determination of whether a non-resident is engaged in business in Canada is fact-intensive and considers numerous factors such as the location of employees and agents, the place of delivery, and the place of payment.
Proposals for Non-Resident Registration Requirements Effective July 1, 2021
Under the current GST/HST registration rules, if a Canadian purchaser buys digital products or services from a non-resident, unregistered seller, the purchaser is required to self-assess GST/HST and pay the tax to the Canadian Revenue Agency. To increase compliance and level the playing field between resident and non-resident sellers, the Canadian government has proposed that, beginning July 1, 2021, non-resident sellers of digital goods, service providers, and platforms that facilitate sales of third-party sellers (i.e., online marketplaces) will be required to register for GST/HST unless the “small supplier” registration exemption applies. Under the proposed rules, the $30,000 “small supplier” threshold for service and digital goods providers is measured by sales to unregistered Canadian purchasers over a 12-month period, excluding sales made through an online marketplace.
The proposed rules provide that there will be a simplified online registration and tax remittance process for non-resident service providers and sellers of digital goods. These taxpayers and non-resident online marketplaces will be required to collect GST/HST on sales to non-registered purchasers, and, subject to exceptions, the sales will generally be sourced to the purchaser’s usual place of residence in Canada. A purchaser’s usual place of residence will be determined based on information such as home address, billing address, or Internet Protocol address, among other possibilities. Non-resident service providers and sellers of digital goods registered under the simplified procedure will not be able to claim input credits.
Also proposed to be effective July 1, 2021, non-resident online marketplaces will be required to register and will be entitled to claim input credits if registered under the current registration procedure. The $30,000 “small supplier” threshold for non-resident online marketplaces will be measured by total sales of digital products and services to unregistered Canadian purchases over a 12-month period, including sales of non-resident sellers made through the online marketplace. The non-resident online marketplaces will be deemed the seller of sales through the marketplace by non-resident sellers to unregistered Canadian purchasers if the goods are shipped from a Canadian location or are from a Canadian fulfillment center. As the deemed seller, the non-resident online marketplaces will be required to collect and remit GST/HST. Also, the online marketplaces will have a reporting requirement regarding sellers using the platform. Fulfillment businesses in Canada will also be required under the proposed rules to report information about non-resident sellers and the goods stored on their behalf.
reach out to our team if you have any questions or need further assistance.
State and Local Tax Services | <urn:uuid:d1640834-5ac6-4e5b-b084-6c272b4c5dc9> | CC-MAIN-2022-33 | https://www.withum.com/resources/what-to-know-about-the-canadian-gst-hst/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.932219 | 1,460 | 1.945313 | 2 |
Wherever your profession path has taken you, with the ability to talk professionally and effectively to a wide range of individuals is important. Various huge and small advertising agencies have come up in the market and there are multiple profession options obtainable for mass communication graduates. Dr. Reynard’s Grasp of Arts in English is in inventive writing; her Bachelor of Science in Journalism is in strategic communication.
What non-verbal communication does is clarify that intent or the context of a message or it may merely enable individuals to speak when words are inappropriate or inadequate; consider army communications in a battlefield or a long stare at an individual across a crowded room.
By way of using the mass media, people don’t understand their subjection; somewhat, they imagine they’re participating in ritual practices (such as voting in national elections for presidents, or on American Idol for singers) to be able to be a person who acts in accordance with their concepts.
The Musical Theatre minor is designed for students who are fascinated about Musical Theatre and are majoring in Music, in Theatre, or in any other degree program. Via an emphasis on actual-world organizational development, traditional theories of pupil comprehension, and fashionable pedagogy, this course prepares college students to teach a various and eclectic vary of communication programs.
Significance Of Tradition And Communication In Management
See the probabilities on the School of High-quality Arts and Communications. VITAL: Candidates and college students looking for professors to supervise their thesis or analysis challenge can even consult the web site of the college or department of their program of alternative. The Division of Communication, in collaboration with the College of Ottawa’s Co-op office, affords a co-op option to a restricted variety of college students within the MC program.
There is postgraduate provision in Journalism , Victorian Research and Creative Writing​ Employees additionally ship Continued Skilled Growth (CPD) to exterior organisations, with a track document in media coaching and social media improvement. Communication Studies offers the data and abilities wanted to meet a calling to serve Christ in communication-associated professions.anonymous,uncategorized,misc,general,other
Diploma Of Arts And Communication (UniLink) (8 Months)
Here, you will grow personally and professionally as you enhance your communication expertise and be taught how you can make a distinction wherever your profession aspirations lead you.
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College Of High-quality Arts & Communication
Mixed media artists could be thought to be essential members of society due to the artwork they create. Be a part of your fellow future communication educators at GCU and earn your Master of Arts (MA) in Communication with an Emphasis in Schooling diploma. College students from related majors whose future career would require proficiency in public talking, oral communication, performance, and the follow of persuasion would benefit from involvement in the Theatre and Speech program.
Either a complete examination plus 5-6 further elective course credits (college students may decide to take two 1-credit score courses along with Orientation (COM 8008) instead of a three-credit score elective course underneath the advisement of their graduate college mentor) or a written Grasp’s Thesis (6 credit).
On-line Masters In Communication Degree
It was Schopenhauer who first mentioned that each one arts aspire to the condition of music. He has degrees in Speech Communication (B.S. in 1999 and M.A. in 2001) from Central Missouri State University and Communication Studies (Ph.D. in 2010, emphases in Political Communication and Rhetoric) from the College of Kansas. There are a selection of degree packages accessible for differing ranges of interest and commitment.
Marketing communications is the art and science of speaking info that allows an organization to market its services or products better. The remainder of the 60 required items may be fulfilled with any elective Communication courses or cross listed programs in different departments.
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Advertising stands for the first engine in gross sales industry and encompasses three dynamic sections comparable to promotion, creativity and communication. Audiovisual Production Specialists shoot inner FBI footage and use multimedia enhancing software program to prepare presentation files. Be taught to assume critically: UMUC’s on-line packages can assist you develop your international perspective, grow to be an revolutionary thinker, and resolve complex problems. | <urn:uuid:8b89d8b9-b1eb-4b5b-bc71-f7e8f435c59d> | CC-MAIN-2022-33 | https://www.massimocapodieci.com/the-artwork-of-communication.html | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.920978 | 939 | 2 | 2 |
Women in medicine have a full agenda. Thanks to patient monitors, doctors and nurses are sometimes alerted of incoming changes or dangers to the patients state before symptoms of the changes become physically apparent. Some ladies report that using female libido medication prescribed by a doctor actually lowered their libido further.
To increase the life of battery, EDTA is used to dissolve and remove sulfate deposits from lead acid batteries. Instead of using female libido medication, more and more women are turning to natural remedies to stimulate libido. If any skin problem is behind the itchiness, steroid creams as well as taking medication to treat the skin problem first, is the usual course of action suggested by doctors.
Holistic health is an alternative medicine approach to treatment and natural healing of the ‘whole being’ (body, spirit and mind), considering mental well-being is as important as physical and that they are closely interconnected. Medicine, which is one subject covered in reference materials, pertains to the science of maintaining good health in living creatures through the diagnosis, treatment and prevention of disease and other damage to their bodies or minds.
If there are any queries about medication that has been prescribed for you that have not been explained to you or you need something to be clarified speak to the doctor who prescribed the medicine, this could be the ward clinician if you are in hospital or your GP. If you need advice regarding the medicine a pharmacist may be able to help you or advise you on whom you should speak to.
Read on to know all about gum diseases, their symptoms, treatments and causes. So it does not make sense for them to be paying a high premium for a traditional health insurance plan with a co-pay, particularly when their medical treatments are not covered anyway. | <urn:uuid:7dbd6d95-34a9-4399-9611-b1e813e9ed98> | CC-MAIN-2022-33 | https://www.ogm-debats.com/5-ways-to-make-your-penis-strong-2.html | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573104.24/warc/CC-MAIN-20220817183340-20220817213340-00473.warc.gz | en | 0.962264 | 358 | 1.898438 | 2 |
“At the name of Jesus” references.
If Nature bows to the name of Jesus, everything else should do so as well.
Nature’s harp is strung to the glory of God. Jesus is our Sun, Mal 4:2.
Mat 9:9 As Jesus passed on from there, He saw a man named Matthew sitting at the tax office. And He said to him, “Follow Me.” So he arose and followed Him.
Luk 8:41 And behold, there came a man named Jairus, and he was a ruler of the synagogue. And he fell down at Jesus’ feet and begged Him to come to his house,
Joh 20:31 but these are written that you may believe that Jesus is the Christ, the Son of God, and that believing you may have life in His name.
Act 3:6 Then Peter said, “Silver and gold I do not have, but what I do have I give you: In the name of Jesus Christ of Nazareth, rise up and walk.”
Eph 5:20 giving thanks always for all things to God the Father in the name of our Lord Jesus Christ,
Php 2:10 that at the name of Jesus every knee should bow, of those in heaven, and of those on earth, and of those under the earth,
Col 3:17 And whatever you do in word or deed, do all in the name of the Lord Jesus, giving thanks to God the Father through Him.
2Th 1:12 that the name of our Lord Jesus Christ may be glorified in you, and you in Him, according to the grace of our God and the Lord Jesus Christ.
How to treat the disorderly and non-believers:
2Th 3:6 But we command you, brethren, in the name of our Lord Jesus Christ, that you withdraw from every brother who walks disorderly and not according to the tradition which he received from us.
1Jn 3:23 And this is His commandment: that we should believe on the name of His Son Jesus Christ and love one another, as He gave us commandment.
SUPPORT MY PODCAST! https://anchor.fm/revessie/support | <urn:uuid:cd7c7ee9-4852-484e-ae5c-ab9acd87df97> | CC-MAIN-2022-33 | https://revessie.com/2021/03/16/good-tuesday-morning-3-16-21/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573540.20/warc/CC-MAIN-20220819005802-20220819035802-00473.warc.gz | en | 0.958831 | 477 | 1.734375 | 2 |
Source: The Weather Channel
The search resumes Monday for victims of a vicious tornado outbreak that ripped across the South on Sunday killing at least 23 people in Alabama.
The violent storms left debris strewn across southern Alabama and Georgia, the Florida Panhandle and into parts of South Carolina. More than 10,000 homes and businesses still had no electricity as of 8 a.m. Monday, according to poweroutage.us.
“Much colder air is pushing into the South from the Midwest, and that will make conditions even worse for those without power into midweek,” weather.com meteorologist Christopher Dolce said. Parts of Alabama and Georgia will see low temperatures in the 20s and low 30s each morning Tuesday through Thursday”
The Lee County Sheriff’s Office told local media that no fewer than 23 people were killed when the tornado roared through the community of Beauregard in southern Alabama county shortly after 2 p.m. CST.
“The devastation is incredible,” Sheriff Jay Jones told WRBL.
The sheriff later said some of the victims were children, and two people were in intensive care. WRBL said at least 40 people were injured in the storm.
Hospitals in the Beauregard area have canceled elective surgeries so they can care for the number of people injured in the storms, Dave Malkoff of The Weather Channel reported.
The National Weather Service said the twister was at least EF3 in strength and was a half-mile wide or more.
Sunday was the deadliest day for tornadoes in the United States since May 20, 2013.
“We’ve still got people being pulled out of rubble,” Lee County Coroner Bill Harris told AL.com. “We’re going to be here all night.”
Copeland said Lee County schools are canceled Monday because “several huge holes are on top of the (elementary) school.”
The storm also destroyed the Buck Wild Saloon and damaged a gas station. It also toppled a cell phone tower across U.S. 280.
“I’m begging people to stay home … and stay off the roads,” Copeland said, so search and rescue efforts can continue.
The Lee County storm warnings were two of several tornado warnings issued for Alabama and Georgia on Sunday afternoon.
Reports said multiple homes were damaged in Dupree, Alabama, south of Dothan. Other reports said the airport and a fire station were damaged in Eufaula, Alabama.
Some 30 miles north of Tallahassee, the town of Cairo and its 9,500 residents suffered a direct hit from what appeared to be a tornado on radar. Shortly after, authorities reported widespread damage in the town, but it was unclear if there were any injuries.
Social media was also sharing reports of damage in Perry, Georgia.
Peach County Sheriff Terry Deese said trees were down and some houses were damaged, the Macon Telegraph reported.
While following the storm, Peach County Sheriff’s Sgt. Shane Brooks told the Macon Telegraph he was nearly hit directly by the tornado as he drove down Duke Road in Byron.
“It was moving so fast I didn’t have time do anything but just sit there and hold on,” he told the Telegraph. “It was not something I would want to experience again.”
Crawford County Fire Chief Randall Pate said a tornado destroyed four homes. Pate also reported one injury: a woman whose ankle was broken when her home was damaged.
The Leon County Sheriff’s Office said five homes were destroyed and another five damaged when severe storms hit the Florida Panhandle. At least two people were taken to a hospital.
The NWS said a tornado was confirmed south of Quincy, Florida, in Gadsden County, and another was spotted near Crawfordville in Wakulla County. | <urn:uuid:93cb230a-f4f3-4558-9f01-55ed6b839680> | CC-MAIN-2022-33 | https://nworeport.me/2019/03/04/tornado-outbreak-hits-south-killing-at-least-23-in-alabama/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573540.20/warc/CC-MAIN-20220819005802-20220819035802-00473.warc.gz | en | 0.978619 | 816 | 1.539063 | 2 |
"I am the vine, you are the branches. He who abides in Me, and I in him, bears much fruit; for without Me you can do nothing." (John 15:5 NKJV)
Sometimes we grow impatient in our lives when we don't see the spiritual growth we would like to see. But an important thing to remember about spiritual fruit is that it doesn't grow overnight. It takes time. If I were to plant a peach tree on Monday, I could scarcely expect to enjoy fresh peach cobbler on Friday. It takes time for peaches to reach their full size. I could pull up a chair, sit down, and wait for the peaches to grow, but I still would not see any discernible difference. Even though I can't see it at the time, that fruit is still growing toward maturity.
Another reason we may not see spiritual fruit in our lives is because we don't recognize it as such. Let's take a look at several definitions from the New Testament of what it means to "bear fruit."
Winning others to Jesus Christ and helping them grow spiritually is one form of spiritual fruit. Paul wrote to his friends in Rome, "Often I have planned to come to you...that I might have some fruit among you also, just as among the other Gentiles" (Romans 1:13 NKJV). We also read in Proverbs 11:30 that "the fruit of the righteous is the tree of life, and he that wins souls is wise" (NKJV).
Sharing what God has blessed us with is a way of bearing fruit. When Paul received an offering from the Gentiles for the saints in Jerusalem who were in need, he referred to that offering as fruit: "Therefore, when I have performed this and have sealed to them this fruit, I shall go by way of you to Spain" (Romans 15:28 NKJV, emphasis mine). When I take my finances and invest them through my tithes and offerings, it will result in fruit to my account (Philippians 4:17). Let me add that if your Christianity does not affect your pocketbook, then one has to question how much your Christianity has affected you. It should permeate every area of your life.
Praising and thanking God is another type of spiritual fruit. When we lift our voices in praise to God, it's an offering of fruit to Him. The Bible tells us, "Therefore by Him let us continually offer the sacrifice of praise to God, that is, the fruit of our lips, giving thanks to His name" (Hebrews 13:15 NKJV). You should not be a spectator when it comes to worship. You should engage, because it is offering fruit to the Lord.
Last, our change in conduct and character is fruit. Galatians 5:22–23 tells us, "The fruit of the Spirit is love, joy, peace, patience, kindness, goodness, faithfulness, gentleness and self-control" (NIV). These virtues should be a part of every believer's life. But again, they don't become visible overnight. It takes time for this fruit to grow. Be patient, and sink your roots deeply into the person of Jesus Christ.
One Sunday morning after a service, I began talking with a group of guys who were all brothers. I was pleased to learn that one Christian brother had recently led each of them to the Lord. As we discussed their newfound faith in Christ, I told them, "Just keep moving forward spiritually, because the moment you start relaxing is the moment you start falling back. But if you keep at it and keep applying yourselves to the basic disciplines of spiritual growth, then you will continue to flourish and bring forth fruit."
Whether you've been a Christian for six months, like these brothers, or for six decades, you must continue moving forward in your spiritual walk. God help you and me to fulfill the purpose for which He has created us. May we glorify Him by bringing forth fruit in our lives as we become more like Jesus Christ.
I love to tell stories—but I especially love to tell stories that point to Jesus. That’s one of the reasons I wrote a book about acting legend Steve McQueen. Steve was the King of Cool, but at the end of his life, he encountered the King of Kings. As a result, an American icon became a child of God. This book is our thank-you gift for your donation to Harvest Ministries today. | <urn:uuid:833fa1f7-278a-41c7-8ac9-87908042f9b4> | CC-MAIN-2022-33 | https://www.lightsource.com/ministry/greg-laurie-tv/articles/the-fine-art-of-bearing-fruit-12583.html | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882572304.13/warc/CC-MAIN-20220816120802-20220816150802-00473.warc.gz | en | 0.978893 | 924 | 1.703125 | 2 |
As the corporate media continues to flood the airwaves with the supposed imminent Russian invasion of Ukraine, France, a country supposedly working to build peace in Europe, murdered 40 people in Burkina Faso on February 13.
Western media outlets labeled them simply as “fighters”.
This was neither questioned or thoroughly investigated to verify whether the French claim was true.
For proponents of the NATO-centric world order reading this analysis, it might seem as if France’s aggressive role in Africa is being used as justification for Russian conduct in Ukraine.
Not at all.
But the difference in the volume of information and the tone of how the Western corporate media is covering Russian military maneuvers inside Russia’s own territory and the casual mention of French attack in Burkina Faso is obvious.
Germany’s Deutsche Welle went on to sanitize French intervention in Africa by posting the statement of the French army describing how it “neutralized” 40 people.
The same report stated that the group of people killed in Burkina Faso were the ones “believed to be” responsible for an earlier attack in Benin.
The term “believed to be” accurately captures the situation when issues pertaining to violence used by NATO regimes arise.
Their decision about who is to be murdered is enough to justify intervention in any part of the world.
No major news organization questioned as to what gives France, a state with a horrific track record of massacres and support for despots in Africa, the right to continue meddling in the continent’s affairs.
When Western regimes murder people in the developing world, their labeling of people as “terrorists” should never be taken at face value.
Such claims should be thoroughly investigated.
France’s statements on Ukraine, with its visible mass scale military intervention in the Sahel region, manifests a typical tactic from a hypocrisy playbook of NATO regimes.
The normalization of violence perpetrated by Western regimes is a multidimensional industry.
From movies, TV series to newspapers, violence perpetrated by Western regimes is regularly sanitized and legitimized.
This fact is so obvious that even mainstream media outlets occasionally mention it, to maintain a veneer of objectivity.
At a superficial level, it may seem that NATO regimes possess significant influence to be able to get away with their global meddling and whitewash it.
Such conduct, however, is precisely what fuels people’s resentment towards the oppressive policies of Western regimes.
The world is now entering the stage of a multipolar global order.
France’s hypocritical conduct in Africa and over Ukraine will continue to push people in West Asia, and Africa generally to move away from the NATO regimes.
This development will help further reconfigure the West- centric global order and reinforce multipolarity as the more desirable option for conducting international affairs. | <urn:uuid:b98ea3bb-7515-4691-ac2d-5173f7035026> | CC-MAIN-2022-33 | https://www.icit-digital.org/articles/france-murders-people-in-burkina-faso-but-works-for-peace-in-ukraine | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573540.20/warc/CC-MAIN-20220819005802-20220819035802-00473.warc.gz | en | 0.945173 | 592 | 1.5625 | 2 |
In the wee hours of a summer night in 1954, several Dade County deputies raided a handful of bars and nightspots throughout Miami and Miami Beach in what had popularly become known as their “pervert roundup.” Local law enforcement arrested nineteen “suspected perverts” that August night. Police, politicians, and those connected to the courts often used the term “pervert” to reference those thought to be homosexual or those who challenged gender norms, particularly by wearing clothes traditionally associated with the opposite sex. They raided those places that night just as they had in the past and would continue to do in the future. This was, by no means, an anomalous occurrence. “We don’t want perverts to set up housekeeping in this county,” claimed Dade County Sheriff Thomas J. Kelly. “We want them to know that they’re not welcome.” Read more » [PDF 2.8 MB]
The author would like to express his gratitude to the whole crew connected to the NPS’s important initiative to promote and identify queer historical sites in the United States. Many thanks, in particular,
to Megan Springate and the two anonymous reviewers for providing such thoughtful feedback on an earlier draft of this essay.
“Raiders Seize 19 in Pervert Roundup,” Miami Daily News, August 14, 1954; also see Fred Fejes, “Murder, Perversion, and Moral Panic: The 1954 Media Campaign against Miami’s Homosexuals and the Discourse of Civic Betterment,” Journal of the History of Sexuality 9, no. 3 (July 2000): 305–347.
The views and conclusions contained in the essays are those of the authors and should not be interpreted as representing the opinions or policies of the U.S. Government. Mention of trade names or commercial products does not constitute their endorsement by the U.S. Government.
Part of a series of articles titled LGBTQ America: A Theme Study of Lesbian, Gay, Bisexual, Transgender, and Queer History.
Last updated: August 11, 2017 | <urn:uuid:aab299cf-b95b-4246-ab6d-c6feb7717ffc> | CC-MAIN-2022-33 | https://www.nps.gov/articles/lgbtqtheme-miami.htm | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571745.28/warc/CC-MAIN-20220812170436-20220812200436-00473.warc.gz | en | 0.95722 | 449 | 1.882813 | 2 |
Another thing that sets the PIC apart from the crowd of time consuming cooking home equipment is its velocity. This all-in one cooking solution is so highly effective that it will probably boil water within ninety seconds. It comes with as many as fifty two completely different temperature settings, which make it a breeze to select the exact temperature setting based on the character of food being cooked by you. The intense and clear LIQUID CRYSTAL DISPLAY show in the management panel of the PIC may be very simple to make use of and can be utilized even by those who usually are not very tech savvy. You save a whole lot of time too as a result of the NuWave PIC is much sooner than your common gas stove or electric cooking vary.
If there is one thing that is on the minds of everybody across the nation, it’s maintaining a healthy diet. In a time when people have fast food for dinner more than as soon as per week, it may be just a bit bit tough to get right into a wholesome mindset on the subject of food. If you’re concerned with maintaining a healthy diet, then there is no higher place to begin than in your personal kitchen. Listed here are some suggestions and methods that you need to use to prepare dinner healthy recipes and get your way to a more healthy lifestyle.
That is particularly wonderful in the summertime.
Subsequent is Black Cumin seed. That is truly an unusual spice, and hardly identified outside of India. Many places mistakenly promote Nigella seeds below the identify of black cumin. Black cumin is Bunium persicum, and has a more nutty and earthy aroma than frequent cumin. It’s far thinner and finer in measurement than regular cumin seed. As its title implies, the seeds are black and used commonly in northern Indian Moglai cuisines. It has a sweeter, lemony character with caraway notes. It is commonly used in yogurts, chutneys, curries and biryanis, some garam masalas. In case you get hold of this spice, search for Bunium persicum specifically, or you may get nigella seeds.
Tip #three: Wholesome and Simple Recipes Do not Have to Be Costly to Make 1 small carrot The additional nutrients in cheese assist pregnant women because it aids during baby delivery and also assist in milk manufacturing once the newborn is born. 4) In a gradual cooker, one hour on excessive equals 2 hours on low. Use this for a guide if it’s good to regulate your cooking time.
Fillings may be sweet or savory.
Little dough balls, soaked with scorching water and mixed with honey and ground poppy seeds. Except one has grown up consuming this dessert, it appears exhausting to enjoy. We of the household find these little balls completely irresistible. Grandmas model is good with all the honey, however I have seen savory variations out there additionally. It seems so most of the desserts I grew up with are also identified in savory versions.
There are completely different versions of tips on how to cook dinner them and I’ve one version of my very own from the fundamental and just added some twist through the use of another additional substances. I often cook dinner this on particular occasions but with a slow cooker round you’ll be able to have it so long as you want. Before sharing with you a recipe, I would prefer to share some useful suggestions in cooking meat loaf in a crock pot too.
Subsequent, you want to skip any recipes that require you to make use of kitchen tools you don’t have, unless you may have the power to borrow the equipment from a pal. You may’t make waffles with do-it-yourself ice cream or custard on high in case you don’t personal a waffle iron. | <urn:uuid:e6eb538b-13fd-4c9c-98a5-52939c25fe3b> | CC-MAIN-2022-33 | https://www.sidecargastrobar.com/the-ultimate-solution-for-gastro-bar-cooking-center-as-possible-understand-today.html | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.954574 | 799 | 1.820313 | 2 |
The National Multifamily Housing Council’s latest report on rent collections showing 77 percent of U.S rental households made rent payments as of June 6 is a sign of a “strengthening economy, a recovering job market and robust demand in the apartment industry.”
But NMHC President Doug Bibby warned that despite the positive outlook for the industry, there are significant challenges ahead as the nation comes out of the COVID-19 crisis.
In a statement, Bibby cited construction costs rising at “almost unparalleled rates” that are increasingly impacting the cost of developing affordable apartment homes. He also noted firms are finding it harder to find labor, which is further delaying construction of multifamily properties.
While Bibby lauded federal lawmakers for passing legislation that included nearly $50 billion in rental assistance funds, the national eviction moratorium remains in effect. The ban is set to expire June 30 and it is unclear whether it will be extended.
The National Low Income Housing Coalition is among the groups advocating that the Biden administration extend the moratorium until the rental assistance funds approved by Congress make it to renters who need them to pay back rent. In the meantime, some states, including New York, have their own eviction moratoriums for those impacted by the pandemic that will be in effect for several more months.
Bibby has previously called for the federal eviction moratorium imposed by the Centers for Disease Control and Prevention (CDC) to be lifted now that the rental assistance is being disbursed and the economy is recovering. On Tuesday, he noted the continuation of the policy “will ultimately only serve to place insurmountable levels of debt on already struggling households.”
Rent Collections Data
The June 6 rent collection figure is a 3.8 percentage point decrease from the share that paid rent through June 6, 2020. But NMHC noted that this year, June 5 and June 6 fell on a weekend and may not be a direct comparison to last year’s figures. It may also not be a direct comparison to the May Rent Payment Tracker which showed 80 percent of U.S. rental households made rent payments by May 6.
The payment data was pulled from 11.7 million professionally managed, market-rate units across the country that varies widely by size, type and average rental prices. While the tracker is intended to be an indicator of resident financial challenges, it is also a way to track the recovery as well, including the effectiveness of government stimulus and subsidies.
This week’s report is the latest in the series from the NMHC Rent Payment Tracker, an initiative that partners with industry firms Entrata, MRI Software, RealPage, ResMan and Yardi. While the figures represent a large swath of professionally managed rental properties, they do not reflect many single-family and small multifamily rental properties that are less likely to be professionally managed and are more likely to have residents with at-risk wages, according to research from the Joint Center for Housing Studies at Harvard University. | <urn:uuid:1edae393-829f-4c53-b704-2a527a46f829> | CC-MAIN-2022-33 | https://www.multihousingnews.com/june-rent-collections-hit-77-nmhc/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.963918 | 610 | 1.710938 | 2 |
What Does It Mean Now That The Pfizer Covid
On 8/23/21, the U.S. Food and Drug Administration approved the first COVID-19 vaccine. The vaccine has been known as the Pfizer COVID-19 Vaccine and will now be marketed as Comirnaty , for the prevention of COVID-19 in people 16 years of age and older. Comirnaty is the same vaccine as the Pfizer vaccine. The Pfizer vaccine is also still available under emergency use authorization for people ages 5 through 15.
Compared to an EUA, FDA approval of vaccines requires even more data on safety, manufacturing, and effectiveness over longer periods of time and includes real-world data. The full approval by the FDA means that the Comirnaty vaccine now has the same level of approval as other vaccines routinely used in the U.S., such as vaccines for hepatitis, measles, chicken pox, and polio. The Pfizer COVID-19 vaccine was the first vaccine to receive emergency authorization, which is why it is the first to have enough data to receive full approval. It does not mean anything about the safety and effectiveness of the Moderna or Johnson & Johnson vaccine.
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Can You Get The Covid
Whether youre scheduling your first dose of the COVID-19 vaccine or lining up for your booster, taking the most effective step to protect yourself against the novel coronavirus can be exciting. But if youve got a coldor what feels like one, anywayshould you get the COVID-19 vaccine? Or stay at home and reschedule?
So far, nearly three-quarters of all Americans have received at least one dose of the three available COVID-19 vaccines, per the Centers for Disease Control and Prevention over 71 million have gotten a booster. But as cold and flu season crests, its not always possible to secure an appointment when youre feeling your best.
To make matters more confusing, you might not be able to tell if youre dealing with a cold, the flu, or COVID-19, especially as all three surge and access to testing remains limited. So, can you get the COVID-19 vaccine or booster if youre sick? Heres what infectious disease doctors say.
Myths And Facts About Covid
CDC has updated its recommendations for COVID-19 vaccines with a preference for people to receive an mRNA COVID-19 vaccine . Read CDCs media statement.
Accurate vaccine information is critical and can help stop common myths and rumors. It can be difficult to know which sources of information you can trust. Learn more about finding credible vaccine information.
Below are myths and facts about COVID-19 vaccination.
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What Is The Recommended Timeframe Between Doses
For both the Pfizer and Moderna vaccines, two doses are recommended for the primary series, and both doses must be from the same manufacturer. The second dose of the Pfizer-BioNTech vaccine should be given at least 21 days after the first dose. The second dose of the Moderna vaccine should be given at least 28 days after the first dose. You should not get the second dose sooner than recommended, but if the second dose is delayed, get the second dose as soon as possible.
Vaccine Dosage and Administration for Children
- Adolescents age 12 years and older receive the same dosage of the Pfizer-BioNTech COVID-19 vaccine as adults
- Children age 5-11 years receive one-third of the adult dose of the Pfizer-BioNTech COVID-19 vaccine. Smaller needles, designed specifically for children, are used for children age 5-11 years.
- COVID-19 vaccine dosage does not vary by patient weight but by age on the day of vaccination
- Children need a second dose of the Pfizer-BioNTech COVID-19 vaccine 21 days after their first dose
- CDC recommends that moderately or severely immunocompromised 511-year-olds receive an additional primary dose of vaccine 28 days after their second shot. At this time, only the Pfizer-BioNTech COVID-19 vaccine is authorized and recommended for children age 5-11 years.
CDC recommends that everyone age 12 years and older get a COVID-19 vaccine booster as soon as they are eligible.
Can I Choose Which Vaccine I Want To Take
Perhaps, when the supply of vaccines from all manufacturers becomes readily available. The vaccines will roll out across the country as they are approved for use by the FDA. Once there are multiple vaccines available, you will be able to inquire with providers to see which vaccine they have on hand, but individual providers may offer or only make one vaccine option available.
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Does The Johnson & Johnson Covid
All three FDA-approved or authorized COVID-19 vaccines are safe and highly effective against serious illness, hospitalization, and death. The Janssen vaccine was also shown to be effective against some COVID-19 variants, with research conducted in countries with these more infectious variants including South Africa and Brazil. An added benefit is that the Janssen vaccine requires only a single shot so if you are offered it, you are one and done and dont need to make a second appointment.
What Is Coronavirus Or Covid
Coronaviruses are a large family of viruses that are common in people and many different species of animals. SARS-CoV-2 is a novel coronavirus that has caused a pandemic of respiratory disease named coronavirus disease 2019, which is abbreviated COVID-19.
The predominant strain of the virus in the United States is now the Delta variant. The Delta variant is more than twice as contagious as earlier strains of the virus. Scientists are still trying to determine if this variant causes more severe disease or affects the body differently than other strains.
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How Soon Can You Get Vaccinated After Recovering From Covid
“After testing positive for COVID-19, you will need to postpone getting vaccinated until your symptoms have resolved and you’ve met the criteria for discontinuing isolation,” says Dr. Phillips. “This timeline can vary by person, depending on your symptom severity and the treatments you may have received.”
If you have symptoms, the criteria for ending isolation include:
- 10 days have passed since your symptoms began and
- 24 fever-free hours without the use of fever-reducing medications and
- Your other COVID-19 symptoms are improving
“Some of the other symptoms of COVID-19 may take quite some time to go away. For instance, loss of smell or taste can linger in some people,” says Dr. Phillips. “You do not need to delay vaccination if you’re still experiencing these more mild symptoms of COVID-19.”
If you are not experiencing symptoms, there’s one main criteria for ending isolation:
- 10 days have passed since your positive test
If you begin to develop symptoms during isolation, follow the “if you have symptoms” criteria above before getting vaccinated.
“Someone with an asymptomatic COVID-19 case can get vaccinated as soon as their isolation ends 10 days after testing positive. You don’t need a negative viral test before vaccination,” says Dr. Phillips.
One caveat: If you received monoclonal antibodies or convalescent plasma, you will need to wait 90 days before getting the vaccine.
Preparing For Your Vaccine
You can get a COVID-19 vaccine and other vaccines, including a flu vaccine, at the same visit. Experience with other vaccines has shown that the way our bodies develop protection, known as an immune response, and possible side effects after getting vaccinated are generally the same when given alone or with other vaccines. Learn more about the timing of other vaccines.
You should get a COVID-19 vaccine even if you already had COVID-19.
Getting sick with COVID-19 offers some protection from future illness with COVID-19, sometimes called natural immunity. The level of protection people get from having COVID-19 may vary depending on how mild or severe their illness was, the time since their infection, and their age. No currently available test can reliably determine if a person is protected from infection.
All COVID-19 vaccines currently available in the United States are effective at preventing COVID-19. Getting a COVID-19 vaccine gives most people a high level of protection against COVID-19 even in people who have already been sick with COVID-19.
Emerging evidence shows that getting a COVID-19 vaccine after you recover from COVID-19 infection provides added protection to your immune system. One study showed that, for people who already had COVID-19, those who do not get vaccinated after their recovery are more than 2 times as likely to get COVID-19 again than those who get fully vaccinated after their recovery.
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Can Other Medicines Lower Risk As Well
For people with moderately to severely weakened immune systems , the FDA has authorized a combination of the monoclonal antibodies tixagevimab and cilgavimab to help lower the risk of COVID-19 infection. These medicines can be used in people who do not have COVID-19 and who have not recently been exposed to the virus. Its important to note that they are meant to be given in addition to, not instead of getting the vaccine.
For more information, see Can other medicines lower the risk of COVID-19 infection? in Common Questions About the COVID-19 Outbreak.
If you are concerned about your risk of COVID-19 even after being fully vaccinated, its important to talk to your doctor about your immune status and if you should get additional doses of the vaccine, as well as what else you can do to help lower your risk of infection.
Answers To More Questions About:
CDC does not keep vaccination records or determine how vaccination records are used. To update your records with vaccines you received while outside of the United States, you may:
- Contact the immunization information system in your state. You can find state IIS information on the CDC website.
- Contact your healthcare provider or your local or state immunization program through your states health department.
The CDC-labeled white COVID-19 Vaccination Record Cards are only issued to people vaccinated in the United States. CDC recommends you keep your documentation of being vaccinated in the other country as proof of vaccination. CDC also recommends checking with your primary care provider or state health department for options to document your vaccination status domestically.
If you have received all recommended doses of a COVID-19 vaccine that has been authorized or approved by the U.S. Food and Drug Administration or is listed for emergency use by the World Health Organization , then you are considered to be fully vaccinated. This currently includes the following vaccines:
Visit the clinical considerations webpage for more information.
While COVID-19 vaccines were developed rapidly, all steps were taken to make sure they are safe and effective:
Learn more about developing COVID-19 vaccines.
Yes, you should be vaccinated regardless of whether you already had COVID-19 because:
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Why Boosters Are Needed
While two doses are likely to provide a good degree of protection against severe disease from Omicron for some time, a booster dose offers greater protection.
Current evidence shows your protection against infection after the primary vaccination course decreases over time. Giving a top up vaccine after a primary course helps boost your immunity against COVID-19.
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How Long After Covid
This swelling is a normal sign that your body is building protection against COVID-19. However, it is possible that this swelling could cause a false reading on a mammogram. Some experts recommend getting your mammogram before being vaccinated or waiting four to six weeks after getting your vaccine.
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What’s The Difference Between Fda Approval And Emergency Use Authorization
If a vaccine is fully approved by the FDA, it means that the information on the vaccine and its effects have been thoroughly reviewed, and the FDA has determined that the benefits outweigh the known and possible risks for the people it is meant to help.
In an EUA, the FDA allows the use of a vaccine or drug during a time of emergency, such as the current COVID-19 pandemic, when the available evidence shows the potential benefits outweigh the potential risks. Drugs and vaccines that have been given an EUA continue to be studied in clinical trials. An EUA is not the same as a full FDA approval, which requires a more thorough review of safety and effectiveness.
Even after a drug or vaccine has been given full approval, the FDA might continue to monitor it for unexpected side effects or for more information that might be helpful to know. For example, it is not yet clear how likely it is that someone who gets one of the vaccines could still spread the virus to others. This is still being studied, as are any possible long-term effects of the vaccines. Researchers are also still trying to determine how long the vaccines will provide protection against the virus.
Booster Shots Available For 16 And Older
Vaccine booster shots are now authorized for everyone 16 and older who is fully vaccinated.
In a new incentive announced on December 21, if you get your booster dose at a City-run vaccination site by the end of 2021, you can receive a $100 pre-paid debit card.
Read Also: How Much Is Rapid Test At Cvs
What Should I Do If I Lose My Covid
You have a few options:
Contact your healthcare provider or the location where you were vaccinated. They can print out another copy of your record. Your record will also be in v-safe, if you enrolled in the program. You can fill out an Immunization Record Request Form that goes directly to the state Department of Public Health. If you use this form, you will get a complete history of all vaccines youve gotten, not just the COVID-19 vaccine, and it can take up to 6 weeks to get your records. Please note that this form must be notarized before it is submitted and mailed in hard copy. You will receive a paper record of any immunizations you have received that were reported to the MIIS. You will not receive a COVID-19 vaccine card.
If you were vaccinated at a mass vaccination site, view the instructions for vaccination record requests.
Can People Who Live In Another State Or Country Part Time Get The Covid
Yes. The Massachusetts COVID-19 Vaccination program is intended for individuals who live, work or study in the Commonwealth. You may also get your second dose in Massachusetts if you received the first dose in another state. Please be sure to keep the vaccination card you were given at the time of the first dose.
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What To Do If You Test Positive For Covid
A coronavirus infection is considered a breakthrough infection if you test positive 14 days after your booster dose.
But you may not even realize youve contracted an infection if youve been fully vaccinated and boosted. According to the American Medical Association , about a quarter of people who get a breakthrough infection after a booster dont ever develop any symptoms of infection.
About 50 to 60 percent will develop COVID symptoms, reports the AMA, but these are usually mild. Only about 10 percent of people who develop a breakthrough infection will need to be hospitalized.
Whether you contract an infection without vaccination or with all your doses and boosters, the rules for quarantine are still the same. You may not be as sick if you get COVID-19 after a booster, but youre still capable of transmitting the virus to others.
As of March 2022, the recommends the following quarantine times for infection or exposure:
- 5-day quarantine for people who test positive but have no symptoms
- 5-day quarantine followed by 5 days of mask wearing in public for people who test positive and have symptoms
- 5-day quarantine followed by 5 days of mask wearing in public for people who are exposed to the virus and are unvaccinated or 6 months out from their last vaccine dose
Are The Vaccines Effective
Based on evidence from clinical trials, all three vaccines are 100% effective at preventing serious hospitalizations and deaths. Thats our most urgent, important goal. A recent CDC study of essential workers in real-world conditions found the Pfizer and Moderna vaccines reduced the risk of infection by 80% after 1 dose and 90% after 2 doses. The CDC will continue to provide updates as it learns more about how the vaccines work in real-world conditions.
Also Check: Hank Aaron Dies After Vaccine
How Long After Getting The Covid
It usually takes a few weeks for the body to build immunity after vaccination. That means it’s possible a person could be infected with the virus that causes COVID-19 just before or just after vaccination and get sick. This is because the vaccine has not had enough time to provide protection. You are considered fully vaccinated if you have received two doses of either the Moderna or Pfizer COVID-19 vaccines or a single dose of the Janssen vaccine more than 14 days ago.
Can You Get The Covid Vaccine If You Have Covid
Even if youve had coronavirus, getting the vaccine may help prevent reinfection and lower your risk of transmitting the virus.
After youve had Covid-19, your immune system will learn to recognise the virus and start producing antibodies to fight against it.
You may have immunity against reinfection for some time, but its unknown how long that immunity lasts.
If you are currently experiencing the virus, you should wait until you have recovered and arent presenting symptoms before getting vaccinated.
Recommended Reading: Cvs Pcr Test For Travel Cost | <urn:uuid:25aaf790-939f-4622-aa60-3b9d010cd1c3> | CC-MAIN-2022-33 | https://www.virusinfoclub.com/can-you-get-a-covid-vaccine-if-you-have-covid/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.945929 | 3,800 | 3.03125 | 3 |
Very popular because of GitHub.
Common boo-boos and how to fix them: http://ohshitgit.com/
Starting a new repository/project when you have code ready to commit
git init, then
git statusto see what it sees, then edit
git commit -ato add untracked files and get an editor window to enter/save your commit-message.
- then, if you want to make a repository on GitHub to push to, you go to GitHub site to create the repository, then it gives you the command lines to enter to define the remote and push to it.
Then, after you make more changes
git statusto review
git commit -ato add/commit
git commit -a -m "<commit comment>"if you have short commit comment
git push origin mainto push to GitHub (or GitLab)
git pull origin mainto pull from GitHub/Gitlab into your local instance
removing a file you don't want
- To remove the file from the repo and not delete it from the local file system use:
git rm --cached file.txt
- but GitHub adds messiness https://help.github.com/articles/remove-sensitive-data
In response to: Make sure you you have a clear branch strategy. See http://www.acquia.com/blog/pragmatic-guide-branch-feature-git-branching-strategy versus http://nvie.com/posts/a-successful-git-branching-model/ as two options. A friend responds: Honestly, these are both perfect examples of the unnecessary complexity that a lot of people are creating with Git. It’s the same issue as with Git Flow - sounds great, but the more integration branches and the more merging you do, the harder it gets to reason about the issues that come up. It’s amazing how much you can do with feature branches, merging in one at a time, rebasing before merge to integrate on the branch, and then just tags for releases. Turn the tags into branches if hot fixes required, and then re-tag, push to production and then merge into master after fixing. Optional long running release branches if your clients keep paying you to support 4 yr old releases, but know your life will suck cherry picking and stashing to reuse small units of code and you copy and tweak security patches across the various long running release branches. Other high points are short running feature branches (if your fb's exceed a week you’re doing it wrong) with feature toggles/feature flags and if necessary branch by abstraction to handle longer running rework.
May'2008: Oliver Steele describes his workflow. I use the index as a checkpoint. When I’m about to make a change that might go awry — when I want to explore some direction that I’m not sure if I can follow through on or even whether it’s a good idea, such as a conceptually demanding refactoring or changing a representation type — I checkpoint my work into the index (by doing
add but not
commit). If this is the first change I’ve made since my last commit, then I can use the local repository as a checkpoint, but often I’ve got one conceptual change that I’m implementing as a set of little steps. I want to checkpoint after each step, but save the commit until I’ve gotten back to working, tested code... I actually don’t want the fine-grained history in the repository. I might make a checkpoint every five minutes, and many of these checkpoints are pretty low quality; I don’t want them persisted.
he compares to a different style/workflow used by Ryan Tomayko, which works around his habit of working on unrelated chunks of code in the same working copy, then realizing he wants to commit just some of that work (The Case of the Tangled Working Copy.) The Index is also sometimes referred to as The Staging Area, which makes for a much better conceptual label in this case. I tend to think of it as the next patch: you build it up interactively with changes from your working copy and can later review and revise it. When you’re happy with what you have lined up in the staging area, which basically amounts to a diff, you commit it. And because your commits are no longer bound directly to what’s in your working copy, you’re free to stage individual pieces on a file-by-file, hunk-by-hunk basis.
a commenter compares this to MercurialQueues.
note that both Oliver's and Ryan's processes focus on a single developer. | <urn:uuid:ec257f9b-614e-49e5-8b84-3eec502b4234> | CC-MAIN-2022-33 | http://webseitz.fluxent.com/wiki/GiT | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.920133 | 1,009 | 1.53125 | 2 |
As part of Black Maternal Health Week, Pennsylvania State Rep. Morgan Cephas (D-192nd Dist.) participated in an online forum last Monday focusing on her ongoing fight to reduce the maternal mortality rate in Pennsylvania — a phenomenon that disproportionately impacts women of color.
The Oshun Family Center hosted the webinar titled “Black Maternal Health: Advancing the Village to Hold the Mother,” where Cephas discussed her package of bills that would:
*Offer Medicaid coverage for doulas (H.B. 2109).
*Expand Medicaid coverage for postpartum women (H.B. 2108).
*Add “severe maternal morbidity” to the list of reportable events within the Pennsylvania Department of Health (H.B. 2107).
*Require implicit bias training for health care professionals (H.B. 2110).
“Access to quality health care should never be based on a person’s skin color or zip code,” Cephas said. “However, the maternal mortality rate for women of color remains disproportionately higher than White women and demands collective and immediate action. From legislators to stakeholders, we must come together and work to secure funding, develop policies and pass laws that result in better health outcomes.”
“Black Maternal Health Week has been a passion project for the Maternal Wellness Village and me, due to the personal impact on our lives,” said Saleemah McNeil, founder of Oshun Family Center. “There is strength in numbers, and we rose to the occasion by giving a voice to unheard Black women!”
As the commonwealth combats COVID-19, Cephas also emphasized the need for Pennsylvania’s Department of Health to closely monitor the racial demographics of reported cases and track how many are pregnant women experiencing birth or newborn complications. “There’s no room for discrimination during a pandemic,” she said. “If there’s a correlation between race and care, the issue must be addressed and resolved sooner rather than later. We have to ensure that one public health crisis does not overshadow another, nor leave room for one to worsen another.” Cephas joined advocates from New Voices for Reproductive Justice, In Our Own Voice and Maternal Wellness Village for the digital conversation. Black Maternal Health Week takes place every year from April 11–17 to highlight the need to advance health equity across the country on behalf of all racial and ethnic minorities. | <urn:uuid:125bac0f-4924-483e-8fec-c59018249709> | CC-MAIN-2022-33 | https://www.philasun.com/stateside/pennsylvania-state-rep-morgan-cephas-joins-online-forum-about-reducing-maternal-mortality-rate-for-women-of-color-amid-covid-19-pandemic/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573540.20/warc/CC-MAIN-20220819005802-20220819035802-00473.warc.gz | en | 0.922536 | 522 | 1.9375 | 2 |
It is finally possible to make News and Interests open links in Chrome, or even in any other web browser of your choice. For that, you can use the same trick as you might have been using for Cortana, to redirect its web content to your favorite browser.
News and Interest is a small taskbar panel that shows a weather forecast, news headlines, finances, traffic, and other information when expanded. Since December 2020, this feature is available on the taskbar for those running Windows 10 preview builds from Dev Channel. See how to enable or disable it, or stop it from appearing when you hover over it with your mouse pointer.
You may remember Edge Deflector, a tiny app for Windows 10 that was created in Cortana era. The software serve only one purpose - to intercept Cortana links and send to to your default browser. Both Cortana and News and Interests use the
microsoft-edge:<URL HERE> protocol to ensure that the link is opened in Microsoft Edge. Obviously, Microsoft is interested in making users stick with Edge, its own product. For whose who are not happy with move, Edge Deflector comes into play.
How to Make News and Interests Open Links in Chrome on Windows 10
- Download the latest version of EdgeDeflector from GitHub.
- Install it by following the setup wizard steps.
- Open the Settings app.
- Navigate to Apps > Default apps.
- Click on Choose default apps by protocol.
- Find the
microsoft-edgeentry in the list, and click on the app icon next to it.
- Select EdgeDeflector from the available apps list, and confirm the change.
You are done.
Starting in EdgeDeflector version 220.127.116.11, the app doesn't require administrative privileges, as it makes the changes per-user. Another great change is that the app now shows a post-install greeting page that allows easily configuring the OS to use EdgeDeflector for handing
Winaero greatly relies on your support. You can help the site keep bringing you interesting and useful content and software by using these options: | <urn:uuid:ce23d255-73c5-4f3b-8682-a415d8fa2f12> | CC-MAIN-2022-33 | https://winaero.com/make-news-and-interests-open-links-in-chrome-on-windows-10/amp/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.891163 | 453 | 1.984375 | 2 |
Industry Canada published draft anti-spam regulations Saturday related to last year's passage of the Conservative government's anti-spam bill, C-28. The Industry Canada regulations are in addition to CRTC draft regulations published in late June. Industry Canada said the regulations are “administrative in nature” and define terms used in the anti-spam legislation. “The proposed Regulations specify the meaning of personal relationship and family relationship for the purposes of the Anti-spam Legislation. With respect to obtaining consent to receive messages from unknown third parties, the Regulations define the specific conditions under which consent would be considered valid and additional requirements for the unsubscribe mechanism,” a notice in the Canada Gazette said. The regulations also define the “meaning of membership, club, association, and voluntary organization in order to provide further clarity to those terms within the legislation,” the notice said. Canada's anti-spam legislation received royal assent last December and amends the CRTC Act, the Competition Act, the Personal Information Protection and Electronic Documents Act and the Telecommunications Act. The new law will create measures against malware and the sending of commercial emails without the consent of recipients. The law gives new enforcement powers to the CRTC and the Competition Bureau. The department is accepting comments for 60 days from July 9. | <urn:uuid:788a89d2-b1f4-4d2c-b834-12f4cc4e5016> | CC-MAIN-2022-33 | https://www.thewirereport.ca/2011/07/11/industry-canada-publishes-draft-anti-spam-regs/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573540.20/warc/CC-MAIN-20220819005802-20220819035802-00473.warc.gz | en | 0.94944 | 267 | 1.6875 | 2 |
It is located on South Tryon Street in downtown Charlotte, NC area, and is home to the Bechtler Museum of Modern Art, the Harvey B. Gantt Center for African-American Arts and Culture, the Knight Theater, and the Mint Museum Uptown. It was given this name in honor of Leon Levine, whose foundation supplied funding for the project.
The 25-year Cultural Facilities Master Plan became a reality in November 2003, following a year of research by the Arts & Science Council of Greater Vancouver. It was the next stage in the development of a plan that began in 1976 and resulted in developments such as Spirit Square, Discovery Place, and the North Carolina Blumenthal Performing Arts Center.
The $236 million first phase, including an $84 million endowment, included moving the Mint Museum uptown, a new contemporary art museum named for Andreas Bechtler, a new Afro-American Cultural Center, and a 1200-seat theater. These projects were listed in a bond referendum held in 2001, which was defeated by the voters.
The Campaign for Cultural Facilities was launched in 2006 as a result of the Cultural Facilities Master Plan. Along with a planned endowment from the Mecklenburg County Arts & Science Council and $35 million from Bank of America, Duke Energy, and Wachovia Corp., the $150.5 million plan was to be funded through a 4 percent car rental tax that would have to be approved by the North Carolina General Assembly, and specifically by all legislators from Mecklenburg County.
Wachovia was constructing an office tower and parking garage, though the bank would also construct four of the five attractions provided financing were authorized. The sixth location was Discovery Place, which was undergoing redevelopment at the time. On February 27, the Charlotte City Council was scheduled to vote on whether or not to accept a contract with Wachovia. The car-rental tax raised from 11 percent to 16 percent on December 1, with an estimated annual revenue of $1.35 million.
The First Street Cultural Campus, also known as the Wachovia Cultural Campus, is a $158 million development that broke ground on September 27, 2007. It’s a short ride away from the Newell, NC area.
The Duke Energy Center was intended to be the highest structure on the complex’s grounds. The Harvey B. Gantt Center for African-American Arts & Culture, the Bechtler Art Museum, and the Wachovia Condominium Tower would all be included in the complex’s overall development.
Daniel Stowe Botanical Garden | <urn:uuid:ace725ab-b434-4e8f-8d8f-9d898a5bc8f9> | CC-MAIN-2022-33 | https://concretecharlottenc.com/levine-center-for-the-arts/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.971768 | 534 | 2.109375 | 2 |
Nfkb1 suppresses DNA alkylation-induced tumor formation.
ABSTRACT: NF-κB proteins play a complex role in modulating carcinogenesis following DNA damage. Previous work identified p50/NF-κB1 as a necessary factor in the cytotoxic response to alkylation damage. Recently, these findings were extended to demonstrate that in the setting of alkylation damage, this NF-κB subunit acts as a haploinsufficient tumor suppressor that prevents hematologic malignancy formation.
Project description:NF-?B proteins play a central and subunit-specific role in the response to DNA damage. Previous work identified p50/NF-?B1 as being necessary for cytotoxicity in response to DNA alkylation damage. Given the importance of damage-induced cell death for the maintenance of genomic stability, we examined whether Nfkb1 acts as a tumor suppressor in the setting of alkylation damage. Hprt mutation analysis demonstrates that Nfkb1(-/-) cells accumulate more alkylator-induced, but not ionizing radiation (IR)-induced, mutations than similarly treated wild-type cells. Subsequent in vivo tumor induction studies reveal that following alkylator treatment, but not IR, Nfkb1(-/-) mice develop more lymphomas than similarly treated Nfkb1(+/+) animals. Heterozygous mice develop lymphomas at an intermediate rate and retain functional p50 in their tumors, indicating that Nfkb1 acts in a haploinsufficient manner. Analysis of human cancers, including therapy-related myeloid neoplasms, demonstrates that NFKB1 mRNA expression is downregulated compared with control samples in multiple hematological malignancies. These data indicate that Nfkb1 is a haploinsufficient, pathway-specific tumor suppressor that prevents the development of hematologic malignancy in the setting of alkylation damage.
Project description:Acute pancreatitis (AP) is a common acute abdominal disease, 10-20% of which can evolve into severe AP (SAP) causing significant morbidity and mortality. Bone marrow-derived mesenchymal stem cells (BMSCs) have the potential of repairing SAP, but the detailed mechanism remains unknown. We demonstrate here that microRNA-9 (miR-9) modified BMSCs (pri-miR-9-BMSCs) can significantly reduce the pancreatic edema, infiltration, hemorrhage, necrosis, the release of amylase and lipase. Meanwhile, decreased local/systemic inflammatory response (TNF-α↓, IL-1β↓, IL-6↓, HMGB1↓, MPO↓, CD68↓, IL-4↑, IL-10↑, and TGF-β↑) and enhanced regeneration of damaged pancreas (Reg4↑, PTF1↑, and PDX1↑) are also promoted. But these effects diminish or disappear after antagonizing miR-9 (TuD). Besides, we find that miR-9 is negatively correlated with AP and miR-9 agomir which can mimic the effects of pri-miR-9-BMSCs and protect injured pancreas. Furthermore, we investigate that BMSCs deliver miR-9 to the injured pancreas or peripheral blood mononuclear cell (PBMC), which can target the NF-κB1/p50 gene and inhibit the NF-κB signaling pathway (p-P65↓, NF-κB1/p50↓, IκBα↑, IκBβ↑). Taken together, these results show that miR-9 is a key paracrine factor of BMSCs attenuating SAP targeting the NF-κB1/p50 gene and suppressing the NF-κB signaling pathway.
Project description:We have shown that NADPH oxidase (NOX)5-S may mediate the acid-induced decrease in cell apoptosis. However, mechanisms of NOX5-S-dependent decrease in cell apoptosis are not fully understood. In this study, we found that silencer-of-death domain (SODD) was significantly increased in esophageal adenocarcinoma (EA) tissues, EA cell lines FLO and OE33, and a dysplastic cell line CP-B. Strong SODD immunostaining was significantly higher in low-grade dysplasia (66.7%), high-grade dysplasia (81.2%), and EA (71.2%) than in Barrett's mucosa (10.5%). Acid treatment significantly increased SODD protein and mRNA expression and promoter activity in FLO cells, an increase that was significantly decreased by the knockdown of NOX5-S and nuclear factor κB (NF-κB)1 p50 with their small interfering RNAs. Similarly, acid-induced increase of SODD mRNA was blocked by knockdown of NOX5-S and p50 in a BE cell line CP-A. Overexpression of NOX5-S significantly increased SODD protein expression in FLO cells. Moreover, overexpression of NOX5-S or p50 significantly increased the SODD promoter activity and decreased the caspase 9 activity or apoptosis. NOX5-S overexpression-induced increase in SODD promoter activity was significantly decreased by knockdown of p50. In addition, acid treatment significantly decreased the caspase 9 activity, a decrease that was significantly inhibited by knockdown of SODD. Furthermore, chromatin immunoprecipitation assay showed that NF-κB1 p50 bound to SODD genomic DNA containing a NF-κB-binding element GGGGACACCCT. This binding element was further confirmed by a gel mobility shift assay. We conclude that acid-induced increase in SODD expression and decrease in cell apoptosis may depend on the activation of NOX5-S and NF-κB1 p50 in FLO cells.
Project description:The transcription factor, NF-кB, plays a central role in the response to DNA damage. This ubiquitous family of proteins is made up of five subunits: p50 (NF-κB1, p105), p52 (NF-κB2, p100), p65 (relA), relB, and crel that appear in their mature form as dimers. Following stimulation, NF-κB dimers translocate to the nucleus where they bind specific consensus elements (κB-sites) in the promoter region of genes involved in cell survival, inflammation and the immune system. While there is a general propensity of NF-кB to mediate survival, this is not always the case and several reports note the pro-apoptotic nature of the NF-кB pathway. In examining the NF-кB response to DNA damage, we have found that the p50 subunit plays a central role in modulating cytotoxicity following TMZ treatment in malignant glioma. In the current study, given the importance of p50 to the cytotoxic response to TMZ, we set out to identify NF-кB-dependent factors that modulate the response to TMZ. U-87 glioma cells stably transfected with either control-shRNA or p105-shRNA and subsequently treated with temozolomide (TMZ) were selected for RNA extraction and hybridization on Affymetrix microarrays. Each category contains 3 biologic replicates.
Project description:BACKGROUND: Nuclear factor-κB (NF-κB) and small ubiquitin-like modifier (SUMO4) are key transcription factors involved in the regulation of immune responses and apoptosis. The aim of this study is to test for the association of NF-κB and SUMO gene polymorphisms with the susceptibility and severity of psoriasis among Saudi cases. SUBJECTS AND METHODS: This is a case controlled study including 85 Saudi psoriasis patients in addition to 92 matched healthy unrelated controls from the same locality. For all participants, DNA was analyzed by PCR for characterization of NF-κB1 -94 del/ins ATTG, NF-κB IA 2758 A>G and SUMO rs237025 G>A gene polymorphisms. RESULTS: Compared to controls, psoriasis patients showed a non-significant difference for all frequencies of genotypes and alleles of NF-κB1 ins/del, NF-κB1A A>G and SUMO4 G>A polymorphisms (p>0.05). However, cases with the plaque type had significantly higher frequency of the SUMO4 A allele carriage (GA+AA genoytpes) than the guttate type (78.6% vs. 21.4%, p=0.02). The PASI score was also significantly higher among cases with the NF-κB1A AA genotype than other cases (p=0.00). CONCLUSION: Genetic polymorphisms of NF-κB1-94 ins/del ATTG, NF-κB IA 2758 A>G and SUMO4 rs237025 G>A were not associated with the susceptibility to psoriasis vulgaris in Saudi patients. However, it might be associated with the expressivity of the disease in terms of its clinical type and severity.
Project description:As an ent-kaurene diterpenoid isolated from Isodon eriocalyx var. Laxiflora, Eriocalyxin B (EriB) possesses potent bioactivity of antitumor and anti-autoimmune inflammation, which has been suggested to work through inhibition of NF-kappaB (NF-κB) signaling. However, the direct target of EriB remains elusive. In this study, we showed that EriB induced apoptosis is associated with the inhibition of NF-κB signaling in SMMC-7721 hepatocellular carcinoma cells. With activity-based probe profiling, we identified p50 protein as the direct target of EriB. We showed that cysteine 62 is the critical residue of p50 for EriB binding through the α, β-unsaturated ketones. As the result, EriB selectively blocks the binding between p50 and the response elements, whereas having no effect on the dimerization or the nuclear translocation of p50 and p65. SiRNA mediated knockdown of p50 attenuated the apoptosis induced by EriB in SMMC-7721 cells. Taken together, our studies illustrated that EriB induces cancer cell apoptosis through interfering with the binding between NF-κB and the response elements by targeting the cysteine 62 of p50, which highlights its potential for the development of p50 targeted cancer therapeutic agents.
Project description:Since the discovery that deletion of the NF-κB subunits p50 and p52 causes osteopetrosis in mice, there has been considerable interest in the role of NF-κB signaling in bone. NF-κB controls the differentiation or activity of the major skeletal cell types - osteoclasts, osteoblasts, osteocytes and chondrocytes. However, with five NF-κB subunits and two distinct activation pathways, not all NF-κB signals lead to the same physiologic responses. In this review, we will describe the roles of various NF-κB proteins in basal bone homeostasis and disease states, and explore how NF-κB inhibition might be utilized therapeutically.
Project description:Piperlongumine has anti-cancer activity in numerous cancer cell lines via various signaling pathways. But there has been no study regarding the mechanisms of PL on the lung cancer yet. Thus, we evaluated the anti-cancer effects and possible mechanisms of PL on non-small cell lung cancer (NSCLC) cells in vivo and in vitro. Our findings showed that PL induced apoptotic cell death and suppressed the DNA binding activity of NF-κB in a concentration dependent manner (0-15 μM) in NSCLC cells. Docking model and pull down assay showed that PL directly binds to the DNA binding site of nuclear factor-κB (NF-κB) p50 subunit, and surface plasmon resonance (SPR) analysis showed that PL binds to p50 concentration-dependently. Moreover, co-treatment of PL with NF-κB inhibitor phenylarsine oxide (0.1 μM) or p50 siRNA (100 nM) augmented PL-induced inhibitory effect on cell growth and activation of Fas and DR4. Notably, co-treatment of PL with p50 mutant plasmid (C62S) partially abolished PL-induced cell growth inhibition and decreased the enhanced expression of Fas and DR4. In xenograft mice model, PL (2.5-5 mg/kg) suppressed tumor growth of NSCLC dose-dependently. Therefore, these results indicated that PL could inhibit lung cancer cell growth via inhibition of NF-κB signaling pathway in vitro and in vivo.
Project description:PURPOSE:To investigate the effect and mechanism of phospholipase C epsilon gene 1 (PLCE1) expression on esophageal cancer cell lines. MATERIALS AND METHODS:The esophageal carcinoma cell lines Eca109 and EC9706 and normal esophageal epithelial cell line HEEC were cultured. The expression of PLCE1, protein kinase C alpha (PKCα), and nuclear factor kappa B (NF-κB) p50/p65 homodimer in cells were comparatively analyzed. The esophageal cancer cells were divided into si-PLCE1, control siRNA (scramble), and mock groups that were transfected with specific siRNA for PLCE1, control siRNA, and blank controls, respectively. Expression of PLCE1, PKCα, p50, and p65 was detected by Western blotting. Transwell assay was used to detect migration and invasion of Eca109 and EC9706 cells. RESULTS:Compared with HEEC, the expression of PLCE1, PKCα, p50, and p65 was increased in Eca109 and EC9706 cells. The expression of PLCE1 was positively correlated with the expression of PKCα and p50 (PKCα: r=0.6328, p=0.032; p50: r=0.6754, p=0.041). PKCα expression had a positive correlation with the expression of p50 and p65 (p50: r=0.9127, p=0.000; p65: r=0.9256, p=0.000). Down-regulation of PLCE1 significantly decreased the expression of PKCα and NF-κB-related proteins (p65: p=0.002, p=0.004; p50: p=0.005, p=0.009) and inhibited the migration and invasion of Eca109 and EC9706 cells. CONCLUSION:PLCE1 activated NF-κB signaling by up-regulating PKCα, which could promote invasion and migration of esophageal cancer cells.
Project description:NF-?B is a major regulator of age-dependent gene expression and the p50/NF-?B1 subunit is an integral modulator of NF-?B signaling. Here, we examined Nfkb1-/- mice to investigate the relationship between this subunit and aging. Although Nfkb1-/- mice appear similar to littermates at six months of age, by 12 months they have a higher incidence of several observable age-related phenotypes. In addition, aged Nfkb1-/- animals have increased kyphosis, decreased cortical bone, increased brain GFAP staining and a decrease in overall lifespan compared to Nfkb1+/+. In vitro, serially passaged primary Nfkb1-/- MEFs have more senescent cells than comparable Nfkb1+/+ MEFs. Also, Nfkb1-/- MEFs have greater amounts of phospho-H2AX foci and lower levels of spontaneous apoptosis than Nfkb1+/+, findings that are mirrored in the brains of Nfkb1-/- animals compared to Nfkb1+/+. Finally, in wildtype animals a substantial decrease in p50 DNA binding is seen in aged tissue compared to young. Together, these data show that loss of Nfkb1 leads to early animal aging that is associated with reduced apoptosis and increased cellular senescence. Moreover, loss of p50 DNA binding is a prominent feature of aged mice relative to young. These findings support the strong link between the NF-?B pathway and mammalian aging. | <urn:uuid:4c0c6531-55f5-440a-8c09-2dcb088ef226> | CC-MAIN-2022-33 | https://www.omicsdi.org/dataset/biostudies/S-EPMC4905238 | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573104.24/warc/CC-MAIN-20220817183340-20220817213340-00473.warc.gz | en | 0.915864 | 3,539 | 1.671875 | 2 |
Sleep and Nutrition
Get Your Kid Some Sleep and Fuel
If there’s one thing you can do to instantly improve your child’s performance, not just on her test prep but on every single thing she does, it’s this:
Make sure your child is getting AT LEAST 7 hours of sleep per night.
This isn’t optional. This isn’t something to be negotiated. If your child is getting less than 7 hours per night, she is going to be a total mental wreck. I want to start this chapter by talking about the “Performance Breaking Point.”
Sleep researchers, neuroscientists, and performance experts have all identified a magic number that I’ll call the Performance Breaking Point: 6 hours of sleep. If you get less than 6 hours of sleep per night, your mental and physical performance can literally be cut in half. If you’re getting less than 6 hours of sleep per night, you might as well not even try to function as a human being.
Two studies will be of particular interest to you:
1. In a recent study, researchers found that adults who got less than 6 hours of sleep per night for only three nights in a row were more dangerous behind a wheel of a car than someone who was legally intoxicated. When you’re sleep deprived, your judgment, your reflexes, your motor skills, your perception, and your general cognitive abilities all fall below the level of someone with a blood alcohol percentage of 0.08%.
If you’re letting your child study while sleep deprived, you might as well let him study while he’s drunk. He’ll get just about the same amount done.
2. In another recent study, researchers found that when people get less than 6 hours of sleep per night for more than five nights in a row, their IQ drops by over 20 points. Just in case you’re not aware, the difference of 20 IQ points is the difference between someone categorized as “Average Intelligence” and someone categorized as a “Genius,” or the difference between someone of “Average Intelligence” and of someone who is “Mentally Handicapped.”
If your child is sleep deprived, he is only 4/5ths as intelligent as he should be.
Sleep deprivation makes you slow, stupid, non-retentive, exhausted, and inefficient.
The most shocking thing about all this research is that most people feel that 6 hours is a sufficient level of sleep. It’s not. Not even close. Below 6 hours, your brain is running on fumes.
Before we get into what you need to do about it, I want to bring up a very common objection I hear from parents and students alike.
“If I sleep for 7 hours a night, I won’t have the time I need to get everything done!”
False. In fact, if you spent more time sleeping, you’ll achieve far more in far less time. Here’s why:
When your brain is sleep deprived, which is defined as “getting less than 6 hours of sleep for more than 2 nights in a row,” your brain is only operating at 70% of its maximum capacity. And that number drops dramatically the less hours you get, or the more nights in a row that you only sleep for 5.5 hours or less.
Let’s assume that your brain can produce “100 widgets of thought” per hour when it’s operating at full capacity. This is a simplification, but it’s important to look at this numerically. If you get 8 hours of sleep a night, that means you have 16 hours to think. In that time, you can produce 1,600 “widgets of thought” in an average day.
Now imagine that you try to produce more “thought widgets” by sleeping less. So you start sleeping for only 6 hours a night. Wow! Two extra hours of production! Sounds like you’ll be getting a lot more done! Until you look at the numbers….
18 hours X 70 widgets per hour (reflecting your reduced efficiency) = 1,260 widgets of thought per day.
Even though giving up sleep can allow you to work for 12.5% more hours per day, you’re actually reducing your mental output by 21.25% a day!
The scary thing is that this isn’t just some hypothetical situation – this is science, pure and simple. When you’re tired, you don’t get as much done. You might think you’re getting more done, because you’re working more hours, but you’re not. You’re actually a shadow of your potential self. And because your judgment is so significantly damaged by your reduced level of sleep, you’re deluded into thinking that you’re still as efficient. Frankly, it’s a horrifying cycle.
“But Anthony – I routinely only get 6 hours of sleep a night, and I feel totally fine!”
This is something I hear all the time from my students and from their parents, whom I expect to set a good example (we’ll get into that in a moment). I have two responses to this claim:
1. You might FEEL fine, but you’re not PERFORMING fine. At all. There’s a big difference between feeling tired and being tired. Some people are able to go through life in a state of pure sleep deprivation without feeling exhausted. But that doesn’t mean they aren’t exhausted. In fact, when you feel tired, it’s not just a sign that you’re “a bit sleepy” – when you feel tired, you are extremely sleep deprived. It’s much like dehydration. You can be completely dehydrated without actually feeling thirsty. Once you feel thirsty, you’re actually already dangerously dehydrated. So you might feel like you don’t need more sleep, but trust science – you do.
2. You’ll feel a lot BETTER if you get some more sleep. I issue you a challenge. If you’re used to getting 6 or less hours of sleep a night, take the next three nights and sleep for 8 hours. Force yourself to do it. Then see how you feel. If you’re like every human being alive, you will end up feeling happier, more energetic, more enthusiastic, sharper, clearer, healthier, more outgoing, and more physically powerful. Once you get used to being properly rested, you’ll quickly realize how “not fine” you actually feel most of the time.
This is a book about test prep, not physical health, but test prep performance only improves when your child’s mind and body are working at optimal levels. If your child’s brain is functioning at 70%, do you think she’ll be able to perform in the 99th percentile on anything?
When your child is sleep deprived, the sleep deprivation has a COMPOUND effect.
Because every aspect of his mental functioning is going to be at or around 70%, he’s actually going to perform at far lower than 70% of his total potential. Think about it in terms of two very simple variables:
If your son is only 70% as attentive as he would be when rested, and if his retention, or memory capabilities, are only at 70% of what they should be, then a session of studying will only yield 49% of the results that it should. He’ll only pick up 70% as much, and he’ll only remember 70% as much of what he does pick up, meaning that he’ll end up learning less than half of what he should.
Sadly, attention and retention are only two of hundreds of variables at play when it comes to mental performance. But they are the two most important factors at play. When it comes to test prep, there are three gears that need to be switched on in your child’s brain:
1. Attention capabilities, which will allow your child to notice what needs to be studied and study it effectively.
2. Calculation and reasoning capabilities, which will allow your child to apply material properly to his or her studies.
3. Retention capabilities, which will allow your child to remember what he/she has learned.
#3 is arguably the most important. What is the point of studying if you’re not going to remember anything that you’ve learned? I’m going to get into the practical applications of this information shortly, but I do need to bring up one last extremely important point:
THE PRIMARY FUNCTION OF SLEEP IS TO ORGANIZE AND SOLIDIFY YOUR MEMORIES. While you’re in the REM (Rapid Eye Movement) stages of sleep, your brain moves the information it came across during the day from short-term to long-term memory. Without REM sleep, you literally don’t remember anything. Researchers have shown that the longer you sleep, the more REM you get proportionally.
In other words, if you sleep for 8 hours, you’re not just getting 1.33 times as much REM as if you sleep for 6 hours. You’re actually getting vastly more. The longer you sleep, the more time your brain spends proportionally in an REM state.
If your child doesn’t get at least 7 hours of sleep a night, she’ll barely remember anything that she studies. This is damning if she’s trying to do better on the SAT or ACT. These tests aren’t ones that you can “cram” for – they require the integration of thousands of long-term memories that students need to be able to access at the drop of a hat.
Don’t expect noticeable results from your child if you’re not requiring him to get enough sleep.
The more sleep you get earlier in life, the healthier your brain and your body will be. It’s upsetting that students sleep the least at a time when they should really be sleeping the most. Lack of sleep can lead to depression, anxiety, weight gain, poor performance, and aggression. Worse yet, lack of sleep can cause or severely exacerbate many of the most common learning disabilities. If your child has ADHD, put him to bed for 8 hours a night and see what happens to his symptoms. Most of the time, the extra sleep will do more than any prescription possibly could.
Hopefully, you’re convinced by now that your child needs to get more sleep. A quick note on how much:
7 hours is considered the “Performance Leveling Point.” In other words, if you sleep for 7 hours or more a night, then you won’t notice a drop in your potential performance. You could theoretically sleep for 7 hours a night every night for the rest of your life performing and feeling perfectly fine.
8 hours is considered the “Performance Enhancement Point.” If you can get 8 hours or more of sleep a night, you’ll actually perform at a higher level than your base level of cognitive performance. If you really want to do well in life, try to get 8 hours of sleep. You might feel like you’re giving up “time to live your life,” but in fact, the life you do live will be happier, livelier, more productive, and vastly more enjoyable.
If you sleep 8 hours a night, one interesting thing you’ll notice is that your friends will start to notice. You’ll suddenly be told that you “look healthier,” that you’re “a better listener,” that you “seem happier,” and that “you’re back to your old self.” That’s because extra sleep makes you more outgoing, more attentive, healthier, happier, and more prone to be around others. Just a nice little fringe benefit…
How To Get Your Kid to Sleep More
Now that you understand how essential sleep is, we need to delve into ways in which you can ensure that your kid gets enough of it. In my experience, there is nothing is more important that parents can do to implement a new routine with their children, than to set the right example themselves.
There is NOTHING that drives adolescents more insane than parents who don’t “practice what they preach.” If you think you can tell your child to go to bed early, then stay late up watching Jimmy Kimmel every night, there is zero chance that your child will follow your request. They will resist you like crazy, because they’ll (easily) realize that you don’t believe in the very thing you’re telling them to do.
If you want your kid to sleep more, the first step is to get to bed at a reasonable time yourself. You can’t skip this option. If you work a night shift, or if you have incredible demands on your time, then make sure that you illustrate to your child that, while you’re not sleeping at the same time that she is, you’re still getting just as much of it.
If you don’t get 7 hours of sleep a night, don’t expect your child to, either. Make sleep a non-negotiable part of your parenting style.
My mother forced me to go to bed at 9pm every single night all the way through 8th grade. We’d usually wake up at 7 or 7:30 to get ready for school the next morning. For the first 14 years of my life, I was getting a minimum of 10 hours of sleep per night. Does this seem excessive? To a lot of my friends, it did. But a lot of my friends didn’t have straight A averages, perfect health, and 99th percentile test scores, either (my brother and I are also about 6 inches taller than anyone else in our family, even though we look exactly like everyone else, which I think had a lot to do with sleep!).
Side note: my GPA all through middle school was a 4.0. Then I went to boarding school and stopped sleeping as much. My GPA was in the bottom fourth of my high school class. Coincidence?
Children react best to well-defined rules that are consistently applied. Childhood psychologists have shown that two factors are more important than ANY others in producing healthy, happy, productive members of society:
1. “Separating the child from the deed.” In other words, when your child does something bad, let her know that you love her, and that she is good, but that her action was bad. On the other hand, when your child does something good, never miss the opportunity to let her know that she did that good thing because she is so good. Children who grow up in an environment of unconditional love, who realize that their parents will always support them, but not their bad behavior, grow up happier, healthier, and more socially adjusted.
2. Well-defined rules with consistent application. If you want to raise a messed up kid, do the following:
A) Tell them they can’t do something.
B) Watch them do it.
C) Don’t punish that behavior.
Or, even worse:
A) Tell them they can do something.
B) Punish them for that behavior.
Kids feel more comfortable when they have an exact idea of what you expect, and when you consistently and rigorously enforce your expectations. This is extremely relevant to sleep.
From now on, you are a “7 hours a night” family. Your children will sleep for seven hours a night.
Minimum. Every night. No exceptions.
You want them to sleep more because you want them to be happier, healthier, and to perform better in school. You really need to make sure that this isn’t seen as a punishment, because it’s not. This is a gift, not a curse. Treat it as such.
“What if my child doesn’t agree?” Here’s where I might step into “insulting territory,” but I have to say this: YOU are the parent, and YOU are the head of your household. Not your child. Sleep is one area where there is no debate. If your child won’t do this on his own, turn off his lights, take his iPhone, unplug his TV, and confiscate his laptop. I’m not kidding. Don’t let your kid push you around. This issue is too important.
That’s all there is to it. Make it happen. All your other efforts will be watered down and ineffective unless you can make sure that your child is getting a healthy amount of sleep.
“But what if my kid insists that he/she can’t meet all his/her demands without staying up later?”
Let me answer this in the most poetic and sophisticated terms possible:
High school is hard. It’s not that hard. If your child can’t fulfill all his or her duties in 17 hours a day, and still have a healthy social life, then I’m George Clooney.
If your child has:
School: 6 hours a day
Homework: 4 hours a day
Sports: 2 hours a Day
Extracurriculars: 2 hours a Day
SAT/ACT Prep: 1.5 hours a Day
Sleep: 7 hours a night
That still leaves him/her with plenty of time to hang out with friends, pursue hobbies, etc. Notice that I assigned 4 hours of homework A DAY. That’s a lot of homework….and I already included sports and extracurriculars into the mix.
Put another way, if your child sleeps 7 hours a night, he has 119 waking hours a week. With the exception of sports matches, weekends have none of the demands that weekdays do. Subtract 30 hours for school, 28 hours for homework (I’m adding 4 hours to each day during the weekend), 15 hours of sports (I’m adding in a 5-hour Saturday match), and 14 hours a week of extracurriculars (I’m adding in a 4-hour debate meet on the weekends), then he still has 32 hours a week to mess around with friends, play the guitar, surf the web, and screw around.
If your child doesn’t think he has enough time to sleep, it’s probably because he’s inefficient and delirious from lack of sleep. I’m not kidding.
If you just read the last few paragraphs, and you honestly think your child can’t possibly function without depriving himself of sleep, then maybe you need to get some more sleep, too!
To sum this chapter up in a few key bullets:
1. If your child doesn’t get at least 7 hours of sleep a night, test prep is pointless.
2. If your child gets 7 hours or more of sleep a night, she’ll be happier, healthier, and better at every single thing that she does.
3. You need to set a good example and get 7 hours of sleep a night yourself.
4. You need to make sleep an inviolable part of your family’s rules – no exceptions.
5. Your child has enough time to get enough sleep, regardless of what they say or think.
A Quick Note on Nutrition
While sleep is the key contributor to your child’s mental performance, nutrition is also absolutely essential. If your child eats chicken nuggets, french fries, chocolate pudding, and Pepsi every day for lunch…that needs to change.
If you want to grab a book on the topic right now, I highly recommend:
Eat, Drink, and Be Healthy: The Harvard Medical School Guide to Healthy Eating
It was written by a bunch of Harvard-ites, so you know that the authors must be wicked ‘smaht.
Considering how much info is packed into that book, it’s a surprisingly easy read, too.
Nutrition is always a controversial and constantly changing topic. One year, eggs are healthy, the next year, they’ll kill you. Now they’re healthy again. But here are a few nutritional points that EVERYONE agrees with, will always agree with, and that will help your child to perform at an elite level at school and on his tests:
- Drinking lots of water is essential. Over half of Americans are chronically dehydrated. Make sure your kid drinks plenty of water – and no, diet soda does not count. 64 Ounces a day of clean water is a good start. Your brain can’t function without water.
- Sugar is bad. Very bad. Reduce the amount of sugar and high fructose corn syrup in your child’s diet. The less, the better. Sugar has been shown to exacerbate learning disabilities and reduce mental performance. Not so good…
- Vegetables are good. Very good. The more vegetables you can feed your kid, the better. While there are different opinions on fruit (some say the sugar outweighs the other benefits), no one disagrees that vegetables are incredibly good for you. Make sure your kid gets at least one serving of veggies per meal, and try to mix it up so that he gets a full nutritional profile.
- Healthy fats are essential for mental performance. Get plenty of Omega 3 fatty acids and other healthy fat sources to fuel your child’s performance. The “low fat diet” myth has been destroyed. Reducing too much fat from your diet is devastating for your neural function. Try to work some fish (especially salmon), avocados, olive oil, nuts and nut butters, etc. into your child’s diet on a daily basis.
- If possible, you should be able to pronounce the ingredients. The jury is still out on exactly how bad aspartame, nitrates, artificial flavorings, preservatives, etc. are for you – but the debate isn’t between “good vs. bad” – it’s between “not that bad vs. absolutely horrible.” Natural foods are less convenient, but far healthier. Try as hard as you can to limit your child’s intake of things you can’t pronounce – no one will argue that eating a chemical lab is good for your performance.
Now that you have the fuel, it’s time to discuss the tools.
If you get your kid enough sleep, feed him right, and keep him hydrated, he’s going to be performing at the highest possible level. Next up, it’s time to give him the tools he needs to achieve the best scores possible. For that, we’ll move on to our next guide! | <urn:uuid:00690070-67a3-4ad5-b557-b4b3663100d8> | CC-MAIN-2022-33 | https://greentestprep.com/resources/for-parents/sleep-and-nutrition/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.9523 | 4,859 | 2.515625 | 3 |
Have a low threshold for suspecting sepsis as the initial clinical presentation of sepsis in chlidren may be non-specific (especially in younger age groups).
Given the time-critical nature of severe sepsis and septic shock, when sepsis is suspected on clinical grounds it is usually best to initiate sepsis investigations and treatment, including administering antibiotics and fluid resuscitation. These should continue until sepsis has been excluded.
Progression to organ failure and shock is often very rapid, so early recognition and treatment is crucial.
Empirical broad-spectrum antibiotic therapy (based on the most probable pathogens) should be administered as soon as possible, and always within the first hour following recognition.
Other treatments are primarily supportive, and should be delivered according to internationally recognised consensus-based guidelines.
Sepsis is a clinical syndrome resulting from a dysregulated immune response to infection. It is characterised by derangements in multiple pathobiological processes, which may lead to widespread tissue injury. It encompasses a clinical spectrum of severity, including severe sepsis, septic shock, and multi-organ failure. Sepsis is a leading cause of morbidity and mortality in children worldwide.
Traditionally, sepsis has been defined based on the presence or absence of the systemic inflammatory response syndrome (SIRS). In adults, the definitions of sepsis were updated in 2016, moving away from the SIRS definition and removing the term 'severe sepsis'.
At present there are no revisions to the international consensus definition of paediatric sepsis, which dates from 2005. However, in 2020 the Surviving Sepsis Campaign proposed a definition for septic shock in children: 'severe infection leading to cardiovascular dysfunction (including hypotension, need for treatment with a vasoactive medication, or impaired perfusion)'.
History and exam
Key diagnostic factors
- presence of risk factors
- fever or low body temperature
- bradycardia (neonates and infants)
- altered mental state or behaviour
- decreased peripheral perfusion
- change in usual pattern of activity or feeding in a neonate
- dry nappies/decreased urine output
- mottling of the skin, ashen appearance, cyanosis
- low oxygen saturation
- non-blanching purpuric rash
Other diagnostic factors
- specific focal signs and symptoms reflecting underlying pathology
- male sex
- younger age (especially neonates)
- perinatal risk factors for infection (neonates)
- healthcare-associated factors (neonates)
- recent surgery or other invasive procedures
- breached skin integrity
1st investigations to order
- FBC with differential
- serum glucose
- blood culture
- urine culture
- blood gases
- serum lactate
- serum electrolytes
- serum creatinine
- coagulation studies
- C-reactive protein (CRP)
- chest x-ray
Investigations to consider
- lumbar puncture
- meningococcal polymerase chain reaction analysis
- bronchoalveolar lavage culture
- herpes simplex virus (HSV) polymerase chain reaction (blood and cerebrospinal fluid)
- serum procalcitonin
- emerging biomarkers
- PhenoTest™ BC Kit
presumed or confirmed sepsis
- Coronavirus disease 2019 (COVID-19)
- Paediatric inflammatory multisystem syndrome
- Congenital heart disease
- Neonatal infection: antibiotics for prevention and treatment
- Evaluation and management of well-appearing febrile infants 8 to 60 days old
Sepsis in children
Pneumococcal vaccine in babies and childrenMore Patient leaflets
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Use of this content is subject to our disclaimer | <urn:uuid:2cb553cd-154e-45bb-91ba-db0f196d106b> | CC-MAIN-2022-33 | https://bestpractice.bmj.com/topics/en-gb/1201 | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.866071 | 917 | 3.28125 | 3 |
This article, “Changes in confirmed plus borderline cases of congenital hypothyroidism in California as a function of environmental fallout from the Fukushima nuclear meltdown” was published in the Open Journal of Pediatrics, a journal published by Scientific Research Publishing (SCIRP), a publisher included on my list of questionable publishers.
The article reports that fallout from the Fukushima nuclear accident increased the number of confirmed congenital hypothyroidism cases in the population studied.
The article’s findings were reported in the media, including a report on ABC 10 in San Diego and Yahoo! News, among others.
However, some independent researchers are questioning the study’s validity. According to Dr. Yuri Hiranuma:
“The actual count of confirmed cases of congenital hypothyroidism (CH) from the California Public Health Department does not match the authors’ count because they disregarded the actual count given to them. Instead, the authors (1) invented their own definition of confirmed cases of CH, (2) misrepresented the real definition of CH, and (3) invented a fictitious diagnostic category of CH which they call “borderline cases. Unfortunately, the study is widely disseminated as the “proof” of the effect of Fukushima fallout on the west coast.”
Dr. Hiranuma wrote up her objections to the study and submitted them as a letter to the journal. However, the journal refused to publish her letter. The letter has since been published on this blog. They sent her this response:
Next, Dr. Hiranuma sent an email asking why the letter would not be published, and she got this reply:
I think one reason they won’t publish the letter is they only want to publish revenue articles — they don’t want to publish a letter for free. The following email confirms this:
Analysis: This is a case of several researchers who are concerned about health effects of radiation exposure using a predatory journal to publish questionable science that bolsters their position on the adverse health effects of low level radiation exposure. Upon publication of the article, they were successful in getting some media outlets to report their findings, and the findings were seen as legitimate because they were published in a scholarly journal. The journal’s publisher remains faithful to its customers (the paper’s authors, who paid to have their article published) and refuses to retract the article or publish a standard response to it. The academic record remains uncorrected.
I recommend viewing the following video, which provides a pitch-perfect explanation of the situation:
By: Jeffrey Beall
Follow on Twitter
Source: Scholarly Open Access
Susan Ariew says:
April 29, 2014 at 9:16 AM
Amazing. This story should go to those news outlets who published the results of the study initially, though I wonder, too, if they will care.
Bill Williams says:
April 29, 2014 at 12:55 PM
This is certainly a scary example of the dangers of predatory publishing.
Bill Williams says:
April 29, 2014 at 3:49 PM
Yes, this is a scary example of the dangers of predatory journals.
April 30, 2014 at 3:07 AM
Duplicate posts: I have wondered why we have seen various near-duplicate posts here. Now it’s happened to me, I see why – its an occasional hiccough with Wordpad: sometimes the platform doesn’t appear to have received our post (as happened to me yesterday) so after some time with nothing appearing, one tries a second time to post the same contribution. Then some time later both appear.
Jeff Shrager says:
April 29, 2014 at 9:55 AM
So, youtube is now a scholarly publisher? I guess at least it’s open access and doesn’t charge for publication. I’m guessing that it’s peer review process leaves something to be desired.
Why don’t they just publish the rebuttal in another journal?
April 29, 2014 at 1:56 PM
MDPI’s Nutrients journal wouldn’t publish my letter either, but underperforming Editor-in-Chief Professor Peter Howe in Australia was happy to publish an “Editorial” slamming me for pointing out that his journal’s quality control was incompetent if not non-existent: http://www.mdpi.com/2072-6643/4/4/258
In part because of this nonsense, Jeffrey Beale has added MDPI to his widely appreciated List of Questionable Publishers: https://scholarlyoa.com/2014/02/18/chinese-publishner-mdpi-added-to-list-of-questionable-publishers/
It will be interesting to see what comes from the University of Sydney’s formal research-misconduct inquiry into its low-GI advocates’ extraordinarily faulty – and self-published – Australian Paradox research: http://www.australianparadox.com/pdf/LettersProfTrewhella.pdf
Here’s Australian national radio’s February 2014 investigation of the matter: http://www.abc.net.au/radionational/programs/backgroundbriefing/2014-02-09/5239418
And here’s my submission to the University of Sydney’s formal research-misconduct inquiry: http://www.australianparadox.com/pdf/RRsubmission2inquiry.pdf
April 30, 2014 at 8:36 AM
Mangano & Sherman have form, and it is not just OA Publishers they use. Take this paper:
Which is published by Baywood. Its analysis has been heavily criticized for similar reasons as this current paper.
Alex SL says:
April 30, 2014 at 4:17 PM
Wow, that is an interesting aspect of not only predatory but open access publishing in general that I had completely overlooked so far. If you run your journal by collecting fees for publication, publishing rebuttals, corrections or letters for free is rather… inconsistent. Where does one draw the line? One could even say that accepting such a letter for free sets a bad precedent in that economic model. And of course retracting something would have to involve reimbursing the publication fee…
The incentives for publishers in an open access system are really problematic. If only we had the political will to create a non-profit publishing system with decent quality control and the right incentives in place instead of trying to “solve” the profiteering problem by shifting the profiteering from reading fees to publishing fees!
Frederick Guy says:
May 8, 2014 at 3:22 AM
This would be a nice point if it were true that subscription-funded publishers did routinely publish letters. Some will publish responses which are essentially mini-papers – others will not even do that, and very, very few will publish letters which, e.g., call out simple logical fallacies or sloppy work. I think it’s mostly because editors would rather not have their own bad judgements publicized. That, in any case, is how it stands in economics and some other social science fields with which I am familiar – unless it’s so different in your field, don’t blame open access.
Susan Ariew says:
June 18, 2014 at 7:27 AM
I warned one of my faculty off of publishing with SCIRP this morning. This blog post helped to explain why journals from SCIRP are not considered reputable OA journals.
Jeffrey Beall says:
June 18, 2014 at 7:28 AM
October 28, 2014 at 3:37 AM
anti-nuclear activists thrive on these predatory journals. The three authors of this article all have been long known to be phony scientists. All are colleagues of Leuren K Moret who has filled YouTube, as has Christopher Charles Busby with false claims about Fukushima. Moret really is on the edge, she claims that the earthquake that triggered the tsunami was caused by US tectonic warfare using the High Frequency Active Auroral Research Program (HAARP) facility at the University of Alaska. Author Busby shares the stage in one video with Moret. Janette Sherman claims that she measured high radiation near the Pentagon on 9/11, proof that the attack was actually by a depleted uranium tipped missile. She also edited NY Academy of Sciences controversial book by Russian pseudoscientists about Chernobyl that claim millions of resultant cancers. Busby claims uranium and depleted uranium are incredibly diabolic and claims to have done epidemiology studies to prove that along with another colleague Mozghan Savabiesafahani who falsely claimed to be a post-doctoral researcher at the University of Michigan doing work for the World Health Organization. These liars and the journals that they choose to post their lies need to be fully exposed and the news media convinced that they are lying for their supper.
Martha McCaughey says:
July 19, 2016 at 11:50 AM
The scary thing is the journalists often simply Google to find experts on the topic they are covering, and these online OA journals pop up in those searches. Journalists as well as current college students and instructors need to know how to tell the difference between questionable, predatory academic journals and real, credible ones. | <urn:uuid:bcd940af-d01b-4ca7-9f47-5d740f9117d0> | CC-MAIN-2022-33 | https://www.emeraldcityjournal.com/2014/04/fallout-from-questionable-article-in-oa-pediatrics-journal/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573104.24/warc/CC-MAIN-20220817183340-20220817213340-00473.warc.gz | en | 0.943973 | 1,999 | 2.0625 | 2 |
Who was the first black woman in music?
In 1920, jazz singer Mamie Smith released a record called “Crazy Blues.” She was the first Black female singer to record and release a blues song.
What female SIngers write their OWn songs?
taylor swift & Other SIngers Who Write Their OWn Songs. MUSIC.
Who is the best American songwriter?
Top 10 songwriters
|1||Bob Dylan||May 24, 1941 – present|
|2||Paul McCartney||June 18, 1942 – present|
|3||John Lennon||October 9, 1940 – December 8, 1980|
|4||Chuck Berry||October 18, 1926 – March 18, 2017|
Who is the most successful female songwriter of all time?
Diane Warren is considered to be among the most prolific and successful contemporary songwriter of our time. A quick glance at her list of Top Ten hits reveals a range of musical genres and styles so diverse it’s difficult to believe the songs could have come from the same person.
Who is the most popular Black woman singer?
1 – Mariah Carey Mariah Carey is the most popular American black singer and actress, born on March 27, 1969. She is known for her five-octave vocal range, melismatic singing style, and signature use of the whistle register.
Who are the most popular Black female singers?
Absolute Best Black Female Singers of All Time
- Chaka Khan.
- Natalie Cole.
- Patti LaBelle.
- Mariah Carey.
- Phyllis Hyman.
- Sarah Vaughn.
- Ella Fitzgerald.
- Popular Posts.
Who is the richest songwriter of all times?
The 20 Richest Songwriters of All Time
- Andrew Lloyd Weber Net Worth: $1.2 billion.
- Paul McCartney Net Worth: $1.2 billion.
- Jay-Z Net Worth $900 million.
- Sean Combs Net Worth: $825 million.
- John Lennon Net Worth of estate: $800 million.
- Bono Net Worth: $700 million.
- Madonna Net Worth: $590 million.
Who are the best black female singers of all time?
Alicia Keys. Alicia Keys became an international star with her singular mix of classic and contemporary R&B.
Who is the best black female singer of all time?
The Greatest Black Female Singers. 1 Whitney Houston. Pop music, Dance-pop. 2 Aretha Franklin. 3 Ella Fitzgerald. 4 Gladys Knight. 5 Etta James.
Why are black female songwriters so important?
The influence of black female songwriters runs deep through the veins of today’s music landscape. It’s important to remember that there are non-performing black woman behind some of your favorite Whitney Houston songs, most of your favorite Rihanna songs, and a number of Nicki Minaj’s best songs.
Who are the top 10 female singers of all time?
1 Aretha Franklin. 2 Ella Fitzgerald. 3 Whitney Houston. 4 Nina Simone. 5 Sarah Vaughan. 6 Billie Holiday. 7 Gladys Knight. 8 Tina Turner. 9 Chaka Khan. 10 Etta James.
Is Beyonce the best black singer?
Maybe you’re one of the millions of Beyonce fans. The R&B singer’s powerful voice and dynamic dance moves have earned her plenty of acclaim as one of the best Black singers, but listeners also love her for her way of redefining pop music with her innovative hits. | <urn:uuid:0f3e9498-a783-4a3f-88d4-8bd15f9ebe6e> | CC-MAIN-2022-33 | https://www.ufoscience.org/who-was-the-first-black-woman-in-music/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.878246 | 767 | 2.40625 | 2 |
What Is Freelancing and How Does It Work?
May 12 2021 - Seeing more freelancers in your company? You're not alone.
The coronavirus pandemic forced many professionals to work from home for the first time. But freelancers have been selling their skills for years.
The allure of freelancing has grown even stronger. 57 million people in the United States did freelance work in 2019.
Freelance has plenty of benefits. From setting your own schedule to pricing, freelancers enjoy a lot of flexibility that you may not find in traditional corporate jobs.
Curious to learn more about the world of freelancing? Read on to find out what is freelancing, how to freelance, how to develop the skills you need, and plenty more.
What Is Freelancing?
The word "freelance" describes an individual who does not work for any one company. Rather, a freelancer works for themselves, selling their skills to use for a variety of companies.
A freelancer may find themselves only working for one company on and off for a number of years. However, freelancers by definition are never employees; rather, they are contract workers.
Freelancers generally work on a project for a set amount of time. Or they offer singular skills, such as:
- blog posts
- content development
- image design
A company may choose to hire a freelancer or a team of freelancers on an ongoing basis, such as blog writers, or researchers. Despite having a steady stream of work, these freelancers are still considered to be contractors, until a formal job offer is made, if any.
How Does Freelancing Work?
There are a number of ways that freelancing works, and all are valid.
Some freelancers are totally independent, connecting with clients on their own and pursuing work individually.
Some freelancers connect with an organization that offers work. Freelance writers are often able to make full-time careers out of working within an organization and picking up work when available.
Other freelancers may pick up jobs for family friends, or offer their services to companies they already have connections with.
The manner of obtaining work is just one piece of the freelancing puzzle. Freelancers maintain their own finances, deal with freelancing taxes, and are expected to manage their own schedules. Deadlines are generally set by the company requesting work, and freelancers work independently to meet those deadlines.
Can Anyone Freelance?
The short answer to this question is yes!
Anyone with marketable skills can freelance. It's a matter of drive and desire.
The first step is identifying your desirable skills. If you're a whiz with the written word, or know your way around Photoshop, there are people looking for those skills.
If you're brand new to freelancing, a quick Google search of "how to become a freelance writer," for instance, shows that plenty of other people are asking the same question. There are plenty of courses that can offer you free training to sharpen those writing skills and become a strong freelance writer.
Can You Make Money With Freelancing?
Again, the short answer to this question is an enthusiastic yes.
Freelancing can be an extremely lucrative career choice, depending on what you do and how hard you work.
For those who desire to work on their own schedules, freelancing can be the perfect gig. Learning a highly desirable skill, and learning to do it well, can lead to some big paychecks.
Lucrative freelancing careers come in a variety of packages, as well. Freelancing is not limited to writing and graphic design. Marketing experts, individuals with Google suite experience, even those who know their way around Facebook can be highly sought after by a variety of companies.
The trick to making money with freelancing is patience and devotion. If you desire to make freelancing a full-time gig, you must put in the time to growing your business - yourself.
If you wish to be entirely independent in your freelancing career, you must be patient for that income stream to come. Take the time to market yourself, reach out to potential connections, and ask around for potential gig opportunities.
Once your gig starts to take off, don't forget to pay your new business plenty of attention. Maintaining your website, relationships with clients, and social pages will only help to keep your skills at the forefront of everybody's minds. Keeping your site and profiles relevant and up-to-date can showcase your skills on a potential client's first visit to your site.
Ready to dive right into freelancing?
Some of the hottest freelance careers right now are in the marketing world. In an ever-evolving digital world, businesses rely on savvy individuals to optimize ad campaigns, make content, and tweak websites to fit Google's evolving specifications.
For these businesses, more optimization and better ads means more revenue. The value of a well-optimized website and efficient ads is nearly immeasurable, as it can truly make or break a website.
Level up your skills in these departments, and you may find yourself with a brand new career.
You can find a variety of courses to give you a further understanding of these marketing techniques. Some are free, and some have a fee. Depending on what you intend to do with your newfound knowledge after completing one of these courses, the cost may be well worth the investment.
There are plenty of other lucrative, money-making freelance opportunities out there. Take the time to research your options. It's handy to have a wealth of resources at your fingertips, such as:
- networks that are hiring freelancers
- companies that need some extra help
- setting up a website and promoting your own freelancing business
Future Freelancing Opportunities
By now, we've answered the hot question - what is freelancing? You are ready to put your specialty skills to use and earn some money, and perhaps even turn your work into a career.
Keep up with the latest news, changes, and tips on jobs of all sorts by checking back with our site frequently. While you're here, check out our other articles for some of the best ideas and tricks to turn your job into something you love.
|Copyright © 1997-2022 Alan Price and HRM Guide contributors. All rights reserved.| | <urn:uuid:f9e7b9be-6645-487b-8ed4-24801ddb8b44> | CC-MAIN-2022-33 | https://www.hrmguide.net/sme/what-is-freelancing.htm | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.954927 | 1,382 | 2.375 | 2 |
OR WAIT null SECS
This instalment describes recent advances and best practices in HPLC analysis of intact monoclonal antibodies (mAbs) and their variants and fragments.
Monoclonal antibodies (mAbs) are highly complex recombinant proteins successfully used as therapeutics in many disease indications. Myriad analytical techniques are required to characterize and control the quality of these molecules during their clinical development and commercial production. This instalment describes recent advances and best practices in high performance liquid chromatography (HPLC) analysis of intact mAbs and their variants and fragments. Application examples, supported by key references, are included to illustrate the utility of diversified HPLC modes to characterize these heterogeneous molecules.
Monoclonal antibodies (mAbs) are established therapeutics with multiple blockbuster drugs in oncology and inflammatory diseases (1–3). According to Genetic Engineering & Biotechnology News published on-line on 3 March 2014, there were five antibody drugs (Humira, Remicade, Rituxan, Avastin, and Herceptin) and one fusion protein (Enbrel) among the top 10 drugs in 2013, and these accounted for nearly $50 billion in global sales. Hundreds of mAbs are currently under clinical development, targeting diseases in autoimmunity, inflammation, cancer, infection, ophthalmology, and other indications (4). Beyond traditional mAb formats, bispecific mAbs and antibody-drug conjugates (ADCs) are major platforms of active research and development (4–7).
Figure 1: Structure of a typical antibody molecule with two identical heavy chains and light chains and antigen-binding sites. VH and VL are the variable domains in the heavy and light chains. The molecules can be cleaved enzymatically into a lower Fc and two Fab fragments. Adapted with permission from reference 8.
MAbs are immunoglobulins (150 kDa) with a typical structure shown in Figure 1 (8). Important structural characteristics and physicochemical properties of mAbs are summarized in Table 1 and have been reviewed (9,10). Biological activity (that is, therapeutic efficacy) of the protein depends on the exact three-dimensional (3D) structure, which is likely affected by post-translational modifications or degradations (11). In contrast with small-molecule drugs, which are chemically synthesized by a variety of processing routes to achieve a high purity product, recombinant human mAbs (rhMAbs) are derived from a fermentation process using host cells such as Chinese hamster ovarian (CHO) cells, followed by extensive purification. Because of their inherent heterogeneity, the quality of mAb therapeutics is controlled by the production cell line and the bioprocessing parameters used for each batch (7,12,13).
Table 1: Important structural characteristics and physicochemical properties of mAbs.
Critical quality attributes (CQAs) of biopharmaceuticals are described by the International Conference on Harmonization Guideline Q8 (R2). CQAs are a set of physical, chemical, biological, or microbiological properties or characteristics that should be kept within an appropriate limit, range, or distribution to ensure the desired product quality, safety, and efficacy. CQAs are monitored closely during each bioprocessing step, and can be incorporated into the release specifications for drug substances and drug products as exemplified by Table 2 (14). Important characteristics such as identity, purity, strength, potency, composition, and safety are obtained from multiple complementary analytical techniques, including various modes of high performance liquid chromatography (HPLC).
Table 2: Typical release tests used for mAb therapeutic products. Reprinted with permission from reference 14.
Principles of quality risk management and assessment and quality by design (QbD) serve as the foundation for current regulatory expectations for process development (15,16). As an integral part of QbD, assessment of CQAs could be based on their impacts in four categories: bioactivity, pharmacokinetics–pharmacodynamics (PK-PD), immunogenicity, and safety. Typical mAb CQAs include size, charge, oxidation, aggregation, glycosylation, and cysteine variants. Other CQAs include process impurities such as residual levels of host-cell DNAs and proteins, antibiotics, as well as contaminants such as mycoplasma, viruses, or proteases (13,15).
Analytical methodologies used for quality control (QC) and characterization are the cornerstones of mAb drug development processes. A well-designed quality control system includes procedure controls (in-process monitoring or controls), raw material or excipient controls, characterization testing, stability testing, and final lot release testing and shipping. Regulatory guidances define the requirements of QC practices, which are applied to characterization and method validation (17). An effective QC strategy should provide assurance that products are safe, have consistent quality, and include standard procedures to guard against unexpected incidents that impact drug quality. In the end, the QC-released mAbs must meet predefined specifications acceptable to regulatory agencies (14).
To monitor the CQAs of heterogeneous mAb products, multiple analytical techniques are used. These include chromatography (HPLC), electrophoresis (capillary gel electrophoresis, capillary isoelectric focusing, sodium dodecyl sulphate polyacrylamide gel electrophoresis [SDS PAGE]), spectroscopy (mass spectrometry [MS], UV–vis spectrophotometry, nuclear magnetic resonance [NMR], infrared [IR] spectroscopy, circular dichroism), and other techniques (multiple-angle laser scattering, differential scanning calorimetry, enzyme-linked immunosorbent assay [ELISA], microbial testing, sterility testing, and binding and functional bioassays) (13,14,18,19). The use of HPLC (11,20–23) and ultrahigh-pressure liquid chromatography (UHPLC) (24–30) for the analysis of proteins and peptides has been reviewed in many books and journal articles (11,20,22–24,26,30,31). In this instalment, we focus our discussion on the various modes of HPLC used for extended characterization, lot release testing, and stability testing of intact therapeutic mAbs and their variant and degradant forms. Selected examples and reviews of key references are used to illustrate the best practices and recent developments in mAb analyses.
Size-exclusion chromatography (SEC) separates molecules based on molecule size by selectively excluding them from an inert porous matrix of controlled pore sizes (32). SEC is typically performed under nondenaturing operating conditions at room temperatures with isocratic mobile phases containing 0.2 M to 0.5 M sodium chloride or potassium chloride and buffered to approximately pH 6. Typical stationary phases are silica- or polymer-based supports with a hydrophilic coating or bonded layer. The Tosoh TSKgel SEC column is widely used in the biopharmaceutical industry for mAbs analyses and has been on the market since 1987 (33).
The recent introduction of ultrahigh-performance SEC columns packed with small particles provides an opportunity for shortened analysis time and better peak resolution. For example, Jeong and colleagues (31) demonstrated a 5-min separation of an Fab dimer and monomer on a 1.7-µm bridged-ethyl hybrid (BEH) column with improved peak resolution in comparison to an existing 30-min standard HPLC separation (31). This fast SEC method has been qualified for robustness, accuracy, and precision. Diederich and colleagues (34) demonstrated that an interlaced injection technique that could further speed up the decreased SEC analysis time. By comparison of three SEC columns (TSKgel 3000 SWxl, Zenix SEC-250 [Sepax Technologies], and Acquity UPLC BEH200 [Waters]) in terms of throughput, resolution, and precision, they indicated that similar profiles were obtained (Figure 2) and that the Acquity UPLC BEH200 column has the highest resolution, whereas the Zenix column offers an economical alternative to the TSKgel column. This UHPLC method has a 6-min cycle time for single injections versus <2-min cycle time in the interlace format (staggered injections).
Figure 2: (a) Overlay of single-injection chromatograms of the mAb sample (1.0 g/L) analyzed on three different SEC columns. (b) For comparability, elution volumes were normalized to column void volumes. Columns: 150 mm à 4.6 mm, 200-à , 1.7-µm Acquity UPLC BEH200 SEC: 250 mm à 4.6 mm, 300-à 3-µm Zenix SEC-250; 300 mm à 7.8 mm, 250-à , 5-µm TSKgel 3000 SWxl. Mobile phase: 0.2 M potassium phosphate buffer at pH 6.2, containing 0.25 M potassium chloride. Adapted with permission from reference 34.
High-molecular-weight species (HMWS) such as aggregates in mAbs have been correlated with immunogenicity, a high-impact safety risk (35). SEC is a key technique to monitor HMWS as well as other low-molecular-weight species (LMWS). Arakawa and colleagues (36) identified several caveats when implementing SEC, such as its low resolution and the potential of nonspecific adsorption on the column, which leads to inaccurate molecular mass estimation. A careful selection of SEC method parameters is therefore needed to obtain useful data that correlate well with results from analytical ultracentrifugation, multiple-angle light scattering (MALS), or MS.
In a critical evaluation of ultrahigh-performance SEC separations for mAbs aggregates, Fekete and colleagues (24) observed high plate counts using sub-2-µm columns, but comparatively higher HMWS values of 7–10% versus approximately 4% with conventional HPLC. Although routine SEC analysis does not require high temperatures, these results suggested the possibility of aggregation artifacts formed during the UHPLC analysis at high temperatures and pressure. Our laboratories are conducting further investigation of this aspect of ultrahigh-performance SEC, and results will be reported elsewhere.
Charge-based separation analyses are typically included in the release and stability specifications for QC and comparability studies to support post-approval process changes. Ion-exchange chromatography (IEC) is a key purity assay for mAb charge variants, which are often functionally active species (37). Polymer-based columns, the most widely used for IEC analysis, are coated with a hydrophilic layer functionalized with ion-exchange groups such as carboxylate, sulphonate, amino, and quaternary amine, and elution is accomplished with salt or pH gradients. Although their numbers are still limited, the increasing availability of sub-3- and sub-2-µm IEC columns is beginning to impact the performance of these separations (38).
Approximately 20% of the amino acid residues in a typical human IgG1 platform molecule are charged in nature. Post-translational modifications or degradations of these charged residues create variant forms, where either a charged site becomes removed (that is, Lys epsilon amine loss by glycation, amino-terminal free primary amine loss by cyclization, carboxyl-terminal Lys cleaved), or a new charged site is produced (for example, Asn deamidation into Asp, glycan sialylation). Alterations in charge-based content of mAb variants impact interaction with IEC ligands, resulting in different retention profiles. An IEC charge variant method can be used analytically for monitoring changes to the product profile, or preparatively as an isolation technique of new variants for further characterization or identification.
An IEC charge variant profile for mAbs is typically generated from a negatively charged carboxylate or sulphonate cation-exchange column. Note that immunoglobulin G (IgG) molecules are generally basic in nature, with an isoelectric point at pI > 7 in a near-neutral pH buffer mobile phase system. An ion-exchange profile ideally presents a predominant main peak with minor flanking regions of acidic and basic variants eluting before or after the main peak, respectively (39). IEC profiles of mAb charge variant forms are typically heterogeneous because of multiple modifications on many sites throughout the molecule, often resulting in a series of unresolved peaks, particularly on the acidic side. In contrast, modifications to the charged termini residues are often well resolved from each other and the main peak.
A comprehensive overview of charge variant modifications and their impact to IEC profile shifts with an extended focus on deamidation and isomerization degradation were documented by Vlasak and Ionescu (40). In a 2001 paper, Harris and colleagues (19) demonstrated the IEC separation, isolation, and subsequent characterization for six different charge variants of the rhuMAb HER2 IgG1 molecule. Strikingly well resolved variants, which differed from the main-peak intact IgG1 native form by a single Asn deamidation (negative charge added, material shifted to acidic) or Asp isomerization (charge preserved, material shifted to basic), illustrated the power of an IEC separation. Chumsae and colleagues (41) profiled a typical mAb IEC separation from which an unusual arginine modification by methylglyoxal was identified by an acidic shift. Removal of positive charges resulted in molecules that were significantly shifted into the acidic region, and seven charge-modified arginine residues, which were located in accessible, flexible complementarity determining region (CDR) sequences, were identified from isolated fractions.
A frequently used strategy to address the poorly resolved charged variants utilizes a digestion of the mAb molecule with papain before IEC profiling. Creation of smaller Fab and Fc portions reduces the complexity generated by multiple modifications across the intact heterodimeric molecule, and often results in cleaner profiles with more distinct peaks. An interesting example from Moorhouse and colleagues (42) illustrated this approach, where Fc C-terminal lysine variants can be separately assessed from Fab amino-terminal glutamine cyclized variant forms. Individual terminal species with charge differences were fully resolved and sequentially eluted in order of increasing pI: Fc + 0 C-terminal K, Fc + 1K, Fc + 2K, Fab + 2 N-terminal pyroglutamates (pE), Fab + 1pE + 1 glutamine (Q), Fab + 2Q.
Pace and colleagues (43) applied this same fragmentation IEC strategy to generate independent Fab and Fc deamidation rates in stability studies to assess and improve product shelf life. Kinetic degradation rates were determined based on the level of acidic charge variants in each fragment in response to varying buffer components, pH, and column temperature. Susceptible deamidation residues in the CDR-containing FAb portion could thus be specifically stabilized to extend shelf life. Zhang and colleagues (44) used IEC to monitor a previously unidentified acidic variant form that occurs in the Fc domain under thermal stress conditions (Figure 3). Characterization analyses of the acidic modification identified Asn-330 as an unexpected site of deamidation and isomerization, in the Val-Ser-Asn-Lys sequence. IEC appears to be able to effectively monitor Fc Asn-330 deamidation and isomerization, a major degradation pathway under thermal stress conditions.
Figure 3: Cation-exchange analysis of mAb A samples under various conditions: (a) unstressed control, (b) thermally stressed at 40 °C for four weeks at pH 5.3, and (c) mAb A treated with pH 8.5. The arrow in (b) points to a new degraded peak unique to thermally stressed samples and termed "AV2B" in the paper. Adapted with permission from reference 44.
Reversed-phase liquid chromatography (LC) analysis of mAbs has multiple applications across all structural levels, from full-sized intact molecules to Fab and Fc fragment molecules and reduced heavy- and light-chain species, and peptide maps generated by proteolytic digestion (11,21,28,45). The broad utility of reversed-phase LC is because of its well-studied hydrophobic separation mechanism, the availability of very efficient reversed-phase LC columns packed with small-particle, nonporous, fully porous, or superficially porous (SPP) materials, and the use of mobile phases compatible with MS for peak identification and structure elucidation (20,45,46).
Many researchers have used reversed-phase LC to exploit these hydrophobic differences in mAb variant forms at the intact or large-fragment levels to provide a quick assessment of process and formulation development samples. Identified variant forms that exhibited altered hydrophobicity (which controls reversed-phase LC retention) include methionine oxidation, glycosylation, disulphide-free thiol status, and amino-terminal cyclization. Peptide mapping by reversed-phase LC–MS is the basis for de novo sequencing, identity assay for lot release testing, and detailed characterization or identification of variant forms (45).
Reversed-phase LC of proteins and peptides has been an area of intensive research for several decades. The fundamentals and separation mechanism are generally understood and well-documented (11,20,23). Recent column developments specifically for mAbs have used approaches such as bonded phases with low silanophilic silica for better peak shape, short alkyl chain length ligands to reduce retention and adsorption, nonporous, superficially porous, or wide-pore materials to improve mass transfer, and sub-3-µm or sub-2-µm particles for enhanced efficiencies (20,23,26,31,46).
Fekete and colleagues (47) explored the impact of mobile phase and column temperature on two new wide-pore packing materials (1.7-µm fully porous and 3.6-µm core–shell particles) on the stability and recovery of commercially manufactured IgG molecules (intact IgGs and fragments: heavy chain, Fc, and Fab). To mitigate strong secondary ionic interactions, the authors operated the column at high temperatures (80–90 °C), along with incorporating small amounts (1–3%) of a protic solvent in the mobile phase (such as n-butanol) to enhance peak shape and recovery. In a separate paper, the same research group demonstrated the use of a coupled-column approach to enhance resolution of mAb separations (30).
An earlier study published by Dillon and colleagues (48) described the use of reversed-phase LC–MS to screen intact mAb for heterogeneity associated with post-translational modifications (that is, glycosylation) and stability degradations (clipped species). In addition, conformational isoforms were detected and attributed to disulphide linkage heterogeneity for an IgG2 (49). Rehder and colleagues (50) applied similar optimization of reversed-phase LC–MS methods to analyze reduced and alkylated IgG light- and heavy-chain (LC and HC) molecules and for monitoring intact glycan distribution (G0, G1, G2, Man5) and amino-terminal cyclizations.
Reversed-phase LC analysis of intact mAb also provided an unexpected separation of free thiol variant forms as demonstrated by Zhang and colleagues (51). Under the denaturing conditions of the reversed-phase LC environment (high temperature, low pH, and organic solvent), variants containing unpaired intrachain disulphides were completely separated from the expected, disulphide-bonded paired cysteine mAb (Figure 4). Free thiol variant forms presented as more hydrophobic than completely disulphide-bonded material, and were observed for both the intact mAb and the FAb fragment. The separated minor peaks, which could be completely converted back into the main peak by CuSO4 treatment, were characterized as the unbonded free thiol form of the Cys22–Cys96 disulphide pair located in the VH region.
Figure 4: Reversed-phase LC profiles for the intact mAb A with buried unpaired cysteines using three different columns: (a) 150 mm à 4.6 mm, 3-µm Agilent (Varian) diphenyl; (b) Zorbax SB-C8; and (c) Agilent (Varian) PLRP-S column; mobile-phase A: 0.1% trifluoroacetic acid in water; mobile-phase B: 0.1% trifluoroacetic acid in acetonitrile; gradient: 36â45% B in 18 min; flow rate: 1 mL/min; temperature: 75 °C; detection: UV absorbance at 280 nm. Adapted with permission from reference 51.
Affinity chromatography (52) utilizes a highly specific, often biologically based binding interaction to capture specific molecules. Antibody molecules themselves frequently serve as highly selective immobilized ligands for isolation of analytes of interest from complex matrices. Common stationary phases in affinity chromatography are protein A or protein G for IgG and boronate affinity for glycated proteins. Affinity chromatography is routinely used during the purification process for therapeutic mAb production. IgG affinity interactions with protein A or protein G are exploited both at large-scale for an initial high-capacity chromatographic separation of the product from host cell materials, and at small-scale for fast, high-throughput analysis for product titre (12). This high-affinity interaction occurs within the Fc CH2–CH3 regions, and after extraneous, nonretained host cell materials are washed through. Isolated IgG is typically eluted with an acidic pH step-gradient wash.
Interestingly, affinity chromatography has been used to further separate Fc region oxidation variants by applying linear gradients for elution. Loew and colleagues (53) explored the impact of oxidation at two highly conserved methionine residues, Met-252 and Met-428, which are located in the Fc CH2–CH3 regions, and are directly involved in the binding interaction with protein A. Schlothauer and colleagues (54) exploited IgG affinity for the neonatal Fc receptor protein (FcRn), a physiologically functional interaction with Fc CH2–CH3 regions. FcRn affinity columns, prepared in-laboratory via biotinylated receptor material coupled to streptavidin-sepharose, were operated under physiological pH gradient conditions to elute bound IgG or Fc material.
Another important application of affinity chromatography is boronate chromatography for antibody glycation characterization. Quan and colleagues (55) used an optimized separation that contained hydroxylated shielding reagents in the mobile phase when assaying basic IgG molecules. Shielded boronate affinity chromatography can be effectively used to quantify, isolate, and characterize glycated IgG1.
Hydrophobic interaction chromatography (HIC) (56) is a separation mode in which the molecules in high-salt mobile phase environments interact hydrophobically with nonpolar stationary phases (for example, hydrophobic ligand bonded to a polymer or a silica support with a hydrophilic outer layer). Common mobile phases are 1–2 M ammonium sulphate buffered at ~pH 6. HIC is an "orthogonal" technique (with very different selectivity) to reversed-phase LC, IEC, or SEC and is useful for characterization of intact and large fragment IgG molecules (56). HIC uses an initial matrix of high-concentration water-structuring salt to expose IgG hydrophobic regions, which can then interact with an alkyl- or phenyl-functionalized stationary phase. A decreasing salt concentration gradient is used to elute the various IgG forms based on relative hydrophobicity. HIC is generally applicable for initial broad fractionation of complex protein solutions (for example, whole cell broths and plasma). However, analytical scientists can apply this technique to effect separations on highly purified IgG product with very subtle modifications. HIC is also a reference technique for ADC drugs for the determination of antibody-drug ratio (57).
HIC methods have provided very effective separations for monitoring mAb aspartic acid isomerization and thiol variants. Cacia and colleagues (58) used an analytical TSK-Butyl (Tosoh) column to separate seven hydrophobically distinct species, related to aspartic acid isomerization variants of an intact IgG1 in a 14-min method. Wakankar and colleagues (59) further utilized an optimized HIC method to generate stability data and degradation rates for Fab aspartic acid isomerization on the same IgG1 molecule. The resulting profile had additional hydrophobic species separated, which were identified as the Fab intact intrachain disulphide and free thiol forms at heavy chain Cys22–Cys29. Harris and colleagues (18) documented the final HIC separation of six Fab-associated peaks: in order of increasing retention and hydrophobicity, LC-Asp32/HC-Cys22-Cys96 disulphide (native material), LC-Asp32/HC-Cys22-Cys96 free thiols, LC-isoAsp32/HC-Cys22-Cys96 disulphide, LC-isoAsp32/HC-Cys22-Cys96 free thiols, LC-Succinimide32/HC-Cys22-Cys96 disulphide, and LC-succinimide32/HC-Cys22-Cys96 free thiols.
Likewise, Dick and colleagues (60) used HIC analysis of an intact mAb for accelerated stability studies by temperature-induced degradation. Isomerization at a heavy-chain CDR2 aspartic acid was quantitatively monitored to establish degradation rates and determine the impact of formulation buffer components. Valliere-Douglass and colleagues (61) used a modified HIC methodology to improve recovery of an IgG2 molecule used in stability studies, by adding acetonitrile to a low pH (5.2) mobile phase and replacing ammonium sulphate with ammonium acetate as the elution salt.
HIC is an important method to determine an overall drug-to-antibody ratio. Wakankar and colleagues used HIC with low concentrations of acetonitrile added to the low-salt mobile phase to help ensure full elution of antibody-drug conjugates (ADCs) loaded with higher-order drug levels. Using a butyl-nonporous stationary phase, five species of an intact IgG linked with an increasing number of a small-molecule drugs (zero, two, four, six, and eight) were baseline resolved in less than 15 min (Figure 5) (57).
Figure 5: Hydrophobic interaction chromatography (HIC) analysis of a mAb-vc-MMAE on a Tosoh Bioscience Butyl-NPR column yields five predominant peaks that correspond to mAb containing zero, two, four, six, and eight small-molecule drugs. Inset: An overlay of the UV spectra of the starting mAb and the HIC peaks, normalized to the 280 nm absorbance, showing the increase in the 248 nm absorbance as the level of conjugated linker-drugs increases. Adapted with permission from reference 57.
The wide applications of HIC for antibody analysis were further demonstrated by Valliere-Douglass and colleagues (62), who developed a variety of finely tuned, optimized HIC separations for intact IgG, Fab, and Fc fragment species. Multiple aspartate isomerization-based intermediates and isoforms in CDRs were fully separated for different IgG molecules. After peaks were characterized, HIC analysis proved to be a superior monitoring method for these degradation changes, as well as for isolating material for functional assessment. Fc fragment variant species were also well separated, including oxidized methionine forms and processed C-terminal forms such as lysine removal and proline amidation. Finally, HIC provided an efficient separation of size-based variant forms, particularly for isolating and enriching clipped species for further characterization.
Mixed-mode chromatography uses multiple forms of interactions between analytes and the stationary phase (for example, IEC, HIC, SEC) (63). Mixed-mode chromatography offers unique selectivity for some variants that are difficult to separate by other modes of chromatography, and has been successfully utilized for large-scale protein purification in biopharmaceutical manufacturing (63). Unlike reversed-phase LC that denatures proteins, mixed-mode chromatography can be applied to isolate mAbs for further biological characterization.
The mixed-mode phenomenon in SEC is a nuance that has been exploited for the separation of oxidized antibodies. By coupling two TSK-Gel (Tosoh) columns in series, Yang and colleagues (64) observed a pre-peak in SEC. Further characterization of the pre-peak revealed the oxidation of trypotophan residues (Trp-103) on the heavy chain of the IgG2. Wong and colleagues (65) exploited the technique to separate oxidation variants by running ultrahigh-performance SEC columns under moderate HIC conditions, which separated an IgG2 into size-related variants, and additionally resolved a monomer pre-peak from the monomer main peak. The pre-peak was confirmed by orthogonal characterization techniques as an oxidized Trp-104 IgG monomer, which was 40–50% less active because of the location of Trp-104 in the CDR. The IgG tryptophan oxidation that was generated under the stressed condition can be clearly monitored by this mixed-mode method.
Hydrophilic-interaction chromatography (HILIC) (56,66,67) provides enhanced retention and selectivity for the separation of polar components. The stationary phases used include bare silica, and silica bonded with amide, amine, cyano, and diol polar functional groups. More complex silica derivatizations produce anion-exchange, cation-exchange, zwitterionic, and mixed-mode stationary phases that can be operated in HILIC mode with appropriate mobile phases. Typical mobile phases are initial high concentrations of polar organic solvents (mostly aprotic but sometimes protic) that are water-miscible (for example, acetonitrile, alcohols) with aqueous buffers for pH and ionic strength control.
HILIC has been applied to mAb carbohydrate analysis, separating these highly polar glycan compounds in a MS-compatible mobile phase. Ahn and colleagues (68) developed a HILIC separation of fluorescently labelled N-linked glycan structures released from human IgG by using UHPLC. Baseline separation was achieved within a reasonable time (<1 h) for the expected neutral and charged glycans, including many structural isomers.
Peptide mapping by HILIC provides complementary information to typical reversed-phase LC maps. Zhu and colleagues (69) applied HILIC peptide mapping with unbonded silica to a highly glycosylated therapeutic protein (erythropoietin [EPO]). Although EPO is not a mAb, this work demonstrated the general applicability of orthogonal selectivity, both for very hydrophilic peptides that are not well retained by reversed-phase LC.
The use of HILIC for intact protein analysis remains limited, primarily because of protein incompatibility issues in the initial mobile phase. Many intact proteins including IgGs, become either denatured or are not soluble in initial conditions. Denatured intact proteins are often not recovered in an active form, or remain irreversibly adsorbed to the HILIC stationary phase. Tetaz and colleagues (66) studied HILIC applications for a set of intact, nonaqueous soluble proteins that are lipophilic or hydrophobic membrane-associated in nature, and demonstrated glycosylation-based, isoform separations of intact proteins.
The emerging antibody formats such as ADCs have created new challenges for separation scientists. The complexity of an antibody coupled with a linker and a cytotoxic drug creates greater heterogeneity in an ADC molecule, and typically does not yield discrete peaks in traditional IEC for mAbs with and without the bound drugs (57). Similarly, bispecific antibodies based on molecules with two different Fabs containing two distinctive binding sites for two different antigens, comprise another platform under intense development (5). The production and assembly of bispecific mAbs are more demanding on separation techniques for greater resolution of numerous variants of the desired forms.
To address the increasing need for higher resolution and selectivity in mAbs characterization, academic research labs have developed new materials that perform beyond the traditional limitations for large molecule chromatography. A notable example is an ultra-efficient chromatography based on submicrometre colloidal silica particles developed by Professor Mary Wirth's group at Purdue University (70). They demonstrated that a novel "slip flow" phenomenon could enable a very high efficiency separation of antibody aggregates in 40 s (Figure 6). The separation can be carried out at room temperature in contrast to typical reversed-phase-UHPLC conducted at higher column temperatures (70–80 °C), avoiding potential on-column degradation.
Figure 6: Separation of a labelled monoclonal antiprostate specific antigen and its aggregate using "slip flow" ultra-efficient chromatography: (a) Silica colloidal crystal: 21 mm à 0.075 mm capillary column packed with 0.47-µm colloidal silica bonded with C4 ligand; mobile phase: 40% acetonitrile in 0.1% trifluoroacetic acid; temperature: ambient. (b) Commercial column, 50 mm à 2.1 mm column packed with 1.7-µm C4 material; temperature: 80 °C. Adapted with permission from reference 71.
Multidimensional LC has been successful for increasing peak capacity for complex samples and is extensively used in proteomics research (71). For mAbs characterization, multidimensional LC techniques can reveal variants undetected in just one mode of separation and provide more in-depth understanding of the molecules. Since minor variants are present at low abundance and are often eluted near other peaks, an effective enrichment technique such as displacement chromatography could be initially applied (39), coupled with a second dimension to achieve better resolution of minor components.
Monoclonal antibody therapeutics require a wide array of HPLC modes for characterization and quality control applications where CQAs such as charge, size, oxidation, cysteine forms, and glycan variants are monitored in process development. These complementary techniques are used to reveal minor changes to the mAb molecules or for the determination of low levels of aggregates, variants, and impurities. Judicious applications of these HPLC separation modes are vital for a more thorough understanding of these complex biopharmaceuticals and their associated manufacturing processes that can impact final product quality. Robust and high-performance HPLC techniques are the cornerstones for mAb development and production, pivotal in assuring the safety and efficacy of these targeted therapeutics for many serious diseases.
The authors are grateful to many colleagues for their useful inputs and suggestions, including Drs. Yung-Hsiang Kao, John Stults, and Reed Harris, and Yi Li of Genentech; Drs. Davy Guillarme and Szabolcs Fekete of University of Geneva; Professor Mary Wirth of Purdue University; Professor Anurag Rathore of Indian Institute of Technology; Chris Pohl of Thermo Scientific; John Batts from IDEX Health & Science; Dr. Tom Waeghe from MacMod; Dr. Di Gao of MedImmune; and C. David Carr of Bioanalytical Technologies. The opinions expressed in this article are solely those of the authors and bear no reflections on those from LCGC Europe or other organizations.
Taylor Yonghua Zhang is a senior scientist and a Group Leader in Protein Analytical Chemistry at Genentech in South San Francisco, California, USA, where he has worked since 2006. He was formerly a research specialist and senior analytical biochemist at Dow Chemical. He received his PhD in analytical chemistry from Iowa State University in 2000. He has more than 10 years of experience in bioprocess development and has authored 20+ publications in the field of bioanalytical chemistry. Dr. Zhang's research interests involve utilizing different separation techniques for therapeutic protein characterization and developing methods for the quality control system. He is also the critical quality attribute (CQA) expert team lead for Genentech/Roche quality by design (QbD) efforts.
Cynthia Quan is a scientist in the Protein Analytical Chemistry Department at Genentech, a member of the Roche Group, located in South San Francisco. She is responsible for analytical characterization, method development, and technical transfers for clinical and commercial products, and for evaluation and implementation of new analytical techniques into legacy commercial control systems. She has more than 20 years of experience in bioprocess development, and has authored seven Chemistry, Manufacturing and Control (CMC) sections for clinical and commercial product regulatory filings, including Investigational New Drug (IND) and post-approval supplements. She has authored or coauthored 14 publications in the bioanalytical chemistry field.
Michael W. Dong is a senior scientist in Small Molecule Drug Discovery at Genentech in South San Francisco, California, USA. He is responsible for new technologies, automation, and supporting late-stage research projects in small molecule analytical chemistry and QC of small molecule pharmaceutical sciences. He holds a PhD in analytical chemistry from the City University of New York and a certificate in Biotechnology from U.C. Santa Cruz. He is the author of Modern HPLC for Practicing Scientists as well as a co-editor of Handbook of Pharmaceutical Analysis by HPLC. He is a member of the editorial advisory board of LCGC North America.
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(71) M. Gilar, A.E. Daly, M. Kele, U.D. Neue, and J.C. Gebler, J. Chromatogr. A1061(2), 183–192 (2004). | <urn:uuid:a100462b-cd85-449d-88c9-018c735a5512> | CC-MAIN-2022-33 | https://www.chromatographyonline.com/view/hplc-characterization-and-quality-control-therapeutic-monoclonal-antibodies-0 | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.875947 | 11,593 | 1.960938 | 2 |
Mainstream Energy, the company behind the Energy Bridge proposal to erect 400 wind turbines across the midlands as Phase 1 of its commitment to supply 5GW of energy into the UK, has this week given its strongest hints yet on where the Westmeath turbines are to go.
A map released by the firm shows three sites in Westmeath – one west of Lough Ennell, in what looks to be the Dysart area; one in the Raharney area, and one around Kinnegad.
In addition, the firm has announced that in September, it will hold formal all-day information clinics at thirteen different venues across five counties for members of the public. There are two be two such days in Westmeath, one at Dysart, and one at Raharney. Also of interest to Westmeath residents will be the information day at Rhode, also scheduled for September.
The company has said that its Phase 1 study area covers 135 square km over seven counties, but that the final area submitted for planning will be significantly reduced as the environmental assessment progresses.
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For extra protein, try this quick and easy taco soup recipe!
There are so many ways to make taco soup, and so many different ingredients to make it with. For this one, we really incorporated as much protein into the recipe as we could so that each cup boasts over 20 grams of protein! Although it’s not common to be deficient in protein, regardless of a child’s diet, healthy sources of protein is important for kids to thrive. Protein provides the building block for muscles, organs, and tissues, giving structure to kids growth and development.
For the protein in our taco soup recipe:
- BEANS– Any taco soup recipe can (and should) include beans! They are a powerhouse food that are full of protein and fiber. On average, beans have 15 grams of fiber per cup. More or less depending on the type of bean. Beans also have between 15-18 grams of protein per cup. There are so many beans to choose from with different flavors, shapes, and sizes, and they all taste great in taco soup. Below is a chart of the different beans and their nutritional breakdown.
In addition to protein and fiber, beans also provide kids with much needed iron and folate! Children ages 4-8 should be getting 200 mcg of folate per day, and 1 cup of beans provides more than 300 mcg! Folate is a nutrient so essential, that it’s been supplemented in our cereals and juices found in grocery stores. Beans are a natural source of this protective B vitamin, so the more the better.
- GROUND TURKEY- Our second source of protein in this taco soup is the ground turkey. We’ve made taco soup with chicken, ground beef, and now ground turkey. They really could be interchangeable, but ground turkey tastes great in this taco soup. 4 ounces of ground turkey contains 27 grams of protein, and this taco soup recipe has 1 pound (108 grams total).
Other ingredients in this taco soup recipe include:
This taco soup recipe would make a quick and easy, high protein, last minute dinner idea for tonight! But if you want to check out our OTHER taco soup recipes we also have:
- 1/2 medium onion
- 2 clove garlic
- 1 pound turkey, ground
- 28 ounce diced tomatoes, canned
- 14 ounce chicken broth, low-sodium
- 6 ounce tomato paste, canned
- 1 tablespoon chili powder
- 1 teaspoon cumin, ground
- 3/4 teaspoon paprika
- 1/4 teaspoon oregano, dried
- 1 1/2 tablespoon Ranch Dressing Seasoning Packet
- 1/4 teaspoon sea salt
- 1/8 teaspoon black pepper, ground
- 1 cup corn, frozen
- 15 ounce pinto beans, canned
- 4 ounce cheddar cheese
- 1 medium avocado
- 4 ounce tortilla chips
- 2 cup pineapple
- Finely dice onion and mince garlic. Spray a large saucepan with cooking spray and heat over medium. Add ground turkey, onion and garlic; cook, stirring to crumble, until browned.
- Add tomatoes, broth, tomato paste and seasonings. Stir to combine; bring to a boil, then reduce heat to a simmer. Simmer for 30 minutes, stirring occasionally.
- Add corn and drained and rinsed beans. Heat through. Sprinkle each serving with grated cheese and diced avocado.
- Serve with tortilla chips and diced pineapple on the side.
I'm a registered dietitian, mom of 4, avid lover of food and strong promoter of healthy habits. Here you will find lots of delicious recipes full of fruits and veggies, tips for getting your kids to eat better and become intuitive eaters and lots of resources for feeding your family.Learn More about Natalie | <urn:uuid:0f2708fa-2a35-4a60-9968-d8318b956a45> | CC-MAIN-2022-33 | https://www.superhealthykids.com/quick-taco-soup-recipe/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573540.20/warc/CC-MAIN-20220819005802-20220819035802-00473.warc.gz | en | 0.912544 | 819 | 1.84375 | 2 |
Our View: Independents deserve a say in primaries
Imagine if states prohibited some citizens from voting based on their political beliefs. The reaction, justifiably, would be outrage. Yet about a dozen states already do exactly that, with hardly a word of protest.
Much of the current national debate over voting rights has centered on overly stringent voter identification laws. But the single largest impediment to voter participation is a system that barely arouses notice: closed primaries that exclude anyone who declines to join a political party.
In the most recent presidential primary election, New York’s on Tuesday, about 1 in 4 voters were prohibited from casting ballots because they do not belong to either major political party. On April 26, the same fate will befall independent voters in Connecticut, Delaware, Maryland and Pennsylvania.
Democrats and Republicans alike have tended to defend or discount the wholesale disenfranchisement of independent voters in closed primaries, arguing that it’s their choice not to join a party. But membership in a party should not be a prerequisite for equal access to the polls when the election is paid for by the public and administered by the state.
More than a dozen states require voters to join a party in advance of primary day. New York sets the most egregious deadline: People must sign up by October of the previous year to vote in a primary. This year, New York will hold three separate primaries: one for president (April), one for Congress (June) and one for state offices (September) — at a cost to taxpayers of about $25 million each.
Some states with semi-closed primaries and caucuses — like Massachusetts, Rhode Island, Iowa and New Hampshire — permit independents to declare a party affiliation on the day of voting, then allow them to revert to their independent status after casting their ballots. (Voters registered with a party may only vote in that party’s primary.) This practice at least ensures that no voter is turned away because of his or her political beliefs.
Nationally, more than 40 percent of voters identify as independents. Compared to party regulars, they are more likely to back outsider candidates and those who buck the party line, which is precisely why many party leaders and ideological activists prefer to exclude them. This year, Vermont Sen. Bernie Sanders and Donald Trump are doing well among independents, who helped propel Barack Obama and John McCain to the general election in 2008.
Of course, requiring open primaries may lead some state parties to switch to caucuses, which have lower turnout and tend to favor partisans over independents. But parties may find that abandoning primaries backfires on them, by making it even harder to reverse their membership declines and fueling support for outsider candidates.
If parties wish to take on the expense of running their nominating process, as they do with caucuses, they are free to set their own rules concerning participation. But when they act in official partnership with state and local governments, and taxpayers spend millions of dollars to administer the nominating contests, then all registered voters should have equal access to the ballot box. | <urn:uuid:d8487613-7a77-4ed3-9da1-69bad69d2770> | CC-MAIN-2022-33 | https://www.tauntongazette.com/story/opinion/editorials/2016/04/23/our-view-independents-deserve-say/31352493007/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573540.20/warc/CC-MAIN-20220819005802-20220819035802-00473.warc.gz | en | 0.960511 | 613 | 2.21875 | 2 |
For negative numbers
Its range is the half-open interval [0, 1).
For opposite numbers fractional parts complement as follows:
Relation to continued fractions
Every real number can be essentially uniquely represented as a continued fraction, namely as the sum of its integer part and the reciprocal of its fractional part which is written as the sum of its integer part and the reciprocal of its fractional part, and so on.
Credits to the contents of this page go to the authors of the corresponding Wikipedia page: en.wikipedia.org/wiki/Fractional part. | <urn:uuid:5da8a6b1-8001-453a-acaf-16326617b10c> | CC-MAIN-2022-33 | http://mediawiki.feverous.co.uk/index.php/Fractional_part | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570879.37/warc/CC-MAIN-20220809003642-20220809033642-00673.warc.gz | en | 0.935377 | 126 | 2.4375 | 2 |
Northwest Airlines flight 1829–stranded on a Detroit taxiway for seven hours with lavatories overflowing and the 198 souls
aboard without food or water–has now landed at the Indiana General Assembly.
Two Republican lawmakers have proposed creating an "airline consumer advocate" to resolve disputes and take legal
action on behalf of passengers who've endured poor service. The measure also would require adequate food, water and other
provisions for those stranded, wheels-down, for more than three hours.
Senate Bill 161 is a response to a growing number of reports of passengers stranded on taxiways since the now-infamous blizzard
that struck Detroit in 1999 and left thousands of passengers aboard aircraft for up to 11 hours.
"We've all heard the horror stories," said Sen. Brent Waltz, of Greenwood. "When you board an aircraft,
a lot of the rights we enjoy as citizens are curtailed. I think it's important to hold airlines to the highest standards."
While Indianapolis International Airport hasn't made national headlines for the kind of nightmarish aircraft internments
that have happened in Detroit, Chicago and New York, Waltz sees the airport only growing in traffic in coming years–especially
with the opening of the midfield terminal late this year.
"The goal is to not have a repeat of the situation in Detroit," said Waltz, who sponsored the bill with Brandt
Hershman, of Monticello.
The bill is patterned after New York state's "Airline Passenger Bill of Rights Law," which went into effect
this month. As with that pioneering legislation, airlines here would be required to provide fresh air and lighting, working
lavatories, and food and drinking water to passengers stranded on planes on the ground three hours or more.
The bill would also create an airline consumer advocate office, within the Office of Attorney General, to investigate passenger
complaints, assist in resolving disputes, and propose civil penalties of up to $1,000 per violation.
According to an analysis by the Legislative Service Agency, the advocate's office could cost the Office of Attorney General
$930,000 a year by 2010. The AG's office, which has 32 vacant positions, estimates that 12 staff members would be required.
Some of the operating costs could come through penalties assessed airlines.
But not everyone thinks such a watchdog agency is a good idea.
"I can't think of a stupider waste of money," said Michael Boyd, president of Evergreen, Colo.-based aviation
consulting firm The Boyd Group. Boyd is a frequent guest on national news programs decrying industry ills and a critic of
the Federal Aviation Administration.
Boyd said that however well-intentioned, such legislation fires in the wrong direction. The bulk of the delays, aside from
severe weather, can be blamed on the FAA's outdated air traffic control system, he said.
The U.S. Department of Transportation's own data show the "national aviation system" is the leading cause of
delays. Though the statistics include the FAA's air traffic control system, they also take into account such factors as
non-extreme weather, airport operations and heavy traffic volume.
Boyd estimates that delays cost airlines $9 billion, despite their efforts to pad their schedules in anticipation of problems
that could bring delays.
"It is irresponsible, irresponsible, irresponsible for state legislators to make the assumption that airlines do this
intentionally," Boyd added.
"This seems to be a bit of political pandering," said Warren Wilkinson, vice president of corporate development
at Indianapolis-based Republic Airways. The regional airline company flies more than 1,200 flights a day for six major carriers,
including American, Continental and Delta Air Lines.
What's next, Wilkinson wondered aloud–a consumer advocate for hotels, taxicabs, restaurants and other segments of the
"Where does it stop and why do they think there's a need to do this in Indianapolis?
"I don't think we need a person sitting in the Attorney General's Office to respond to passenger complaints
when, first of all, Indianapolis is not in the position of a New York or Chicago."
Waltz conceded there are many causes of problems for delays and "trying to assign blame on any one of these is probably
not constructive." He added that, while a cooperative effort is needed to solve customer service issues, airlines must
understand that "the government is concerned."
The Air Transport Association, the trade group for the nation's big airlines, took New York state's passenger bill
of rights to court, but lost its first round. The trade group is considering an appeal.
"ATA's sole purpose in filing [a lawsuit] was to preserve the principle that commercial aviation is best regulated
by one source–the federal government–and not 50 individual states," the association said in a statement.
Senate Bill 161could give airlines an out due to such circumstances as acts of God, a negligent act of a consumer, or an
emergency situation. It wasn't immediately clear whether the measure could conflict with federal regulations.
The U.S. Department of Transportation reported this month that the industry's overall on-time rate was 80 percent in
November, the most recent month for which data are available.
At Indianapolis International Airport, 80.2 percent of arrivals and 85.2 percent of departures during the month were on time,
according to the DOT.
But two routes involving Indianapolis showed up on the nation's most frequently delayed flights: ExpressJet Airlines
flight 2076 from Newark, N.J., to Indianapolis–late 86 percent of the time–and Northwest Airlines flight 669 from New York's
LaGuardia, late 80 percent of time.
Tim and Mary Bruce, of Carmel, who were cooling their heels recently at the airport's McDonald's, said other than
being overbooked several years ago, they really haven't had many problems with carriers in recent years. And they fly
a lot to visit family.
Still, Mary Bruce's first reaction to SB 161: "I think that's wonderful," she said. "A lot of people
have claustrophobia. It would get to you."
Her husband, a stocky man, nodded. He doesn't like being confined in narrow airline seats.
"I don't think $1,000 [proposed fine per violation] is enough," said Tim Bruce. "That's pocket change
to an airline."
Besides, to the extent airlines are responsible for problems such as delays, think of the consequences, he said: passengers
missing connecting flights, relatives traveling to the airport to pick up family, for example. "It's a snowball effect."
Many of the most extreme horror stories involving passengers stranded in aircraft involve weather. An ice storm last February
kept several JetBlue Airways planes parked at New York's John F. Kennedy International Airport about eight hours. JetBlue
said no gates were open to accommodate the aircraft.
The woes of stranded passengers were perhaps best chronicled by a Wall Street Journal report on Northwest flight
1829, in Detroit, nine years ago.
The account told of passengers reporting chest pains and flying into fits of rage and of one woman who lunged to open an
aircraft door, only to collapse onto the floor, sobbing.
Food and water ran out. Lavatory storage tanks were full. Mothers ran out of formula and diapers for children. Some passengers
said they were careful not to allow other passengers to catch a glimpse of snacks they had in purses or bags, for fear they'd
be attacked as they retrieved them.
Indianapolis Airport Authority officials wouldn't say what was on their mind regarding SB 161.
"If the bill does pass in some form and results in impacts to airport operations or management, we would adjust accordingly,"
said spokeswoman Susan Sullivan.
Faced with a flurry of cancellations and delays, the airport often takes steps such as encouraging retailers and concessionaires
to remain open longer. | <urn:uuid:193ff494-c765-4a9f-850f-b800e48156e0> | CC-MAIN-2022-33 | https://www.ibj.com/articles/13783-lawmakers-call-for-advocate-to-support-airline-passenger-rights | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.962948 | 1,671 | 1.765625 | 2 |
Stroll through the cubicles at the average office and you’ll see people slumping, hunching, and poking their heads out like turtles as they sink further toward their computer monitors or laptops.
Come back at the end of the day and you’ll see a bunch of people with headaches.
“Chronic headaches and migraines are the top symptoms that bring people in,” says Dr Pritchett. “Tension in the suboccipital muscles is the main cause of this, and that is due to the head-forward posture created by long term sitting.” The suboccipital muscles are the ones at the base of the skull, but the pain can be felt in the forehead, so it can be hard to recognize the cause.
Headaches hurt, and they can be distracting, but they aren’t usually dangerous — just painful.
Thoracic outlet syndrome is another issue caused by sedentary workdays. This is tingling and numbness in the upper extremities due to rounded forward shoulders. A third common problem is hyper kyphosis of the thoracic spine. “This is a long term condition that is hard to reverse,” says Dr. Pritchett. This can develop into the condition sometimes called “Dowager’s Hump” — a permanently rounded back.
When the head is not balanced above the neck and shoulders but is held forward, the result an be as much as 30 pounds of extra pressure on the neck and spine. Better posture is important, but many of us start our days sitting up straight and gradually end up with our noses getting ever closer to that computer screen. Sitting all day is not natural for us, and poor posture is the consequence.
If sitting is the problem, is a standing desk the answer? It can be. However, just switching from sitting all day to standing all day is no improvement. That can lead to lower back problems or circulation issues. It can make you tired, and it can interfere with concentration. And of course we can have poor posture standing as well as sitting.
So the real solution is to move more and change positions more during the day. That doesn’t mean you have to have two desks. An adjustable monitor stand can allow you to sit for tasks that require intense concentration, then stand for a while to get less intense tasks done, and then return to sitting. The changes in position and posture can help reduce the long-term health effects of too much sitting, as well as the pain that comes with poor posture.
Dr. Pritchett is a fan of the Varidesk, a special desk that converts from a sitting to a standing surface in seconds.
Adjustable monitor stands or desks may be covered by your insurance company if you receive a prescription for one. If you suffer from headaches or you’re concerned about your workday posture, visit Millennium Chiro and learn about the benefits of the adjustable monitor stand. | <urn:uuid:e92e09e4-d5be-4d6b-9425-dd89174e0498> | CC-MAIN-2022-33 | https://www.mana.md/will-insurance-cover-standing-desk/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.957777 | 622 | 2.4375 | 2 |
Learn a foreign language with the Nuns using virtual reality
Learning a foreign language using virtual reality has recently become possible at Language Institute Regina Coeli, also known as ‘The Nuns of Vught’. Regina Coeli is the first language institute to make use of virtual reality (VR) in language training to develop students’ communication skills.
VR is extremely well-suited for practicing presentations, job interviews, pitches and the like. With a VR headset on, a student can step into a real-life situation with an audience that responds and even asks questions. Students who have used VR to prepare for these types of situations have shared that the real-life situation has been a great deal easier afterwards.
Virtually travelling to another country
It is also possible to virtually leave our language institute in Vught and journey to other places in the world. This way, a student can use VR to realistically order an espresso in an Italian bar or pay at a Spanish kiosk.
Active grammar practice
A third VR application that Regina Coeli has developed is a grammar exercise. This exercise turns abstract grammar into something tangible which students can actively use.
“Because of the number of stimuli a student gets in the VR environment, he automatically breaks through his fear of speaking, as it were,” says Katharina Stoll, German language trainer and VR Project Manager at Regina Coeli. "We’ve already seen many students who suddenly start talking with their VR headsets on, despite the fact that they were nervous about that prior to using VR.”
Virtual reality is well-suited to private lessons. The language trainer sits in the same room as the student and can guide, ask and correct the student, while the student feels he is in a different place altogether.
Immediate feedback from language trainers
A group of Regina Coeli language trainers started experimenting with the use of VR in language training some time ago, although they soon realised that they could not lean on existing VR applications for learning foreign languages. The conclusion was that blending one-to-one coaching from a language trainer with VR is ideal because of the direct feedback that a language trainer can give on the student’s language use.
Stoll: “We’ve discovered that VR can make a solid contribution to learning provided it fits the learning objectives of the student. The applications we use are suitable for almost every one of our learners.”
VR not a goal in itself
The use of VR at Regina Coeli has been carefully considered. “For us, the use of new applications is not a goal in itself," says Esther van Berkel, Director of Studies at Regina Coeli. "We’re focused on finding opportunities to accelerate the learning of foreign languages. This has definitely been the case when it comes to VR. That’s why we’re also continuing to develop all kinds of applications for VR. We have a broad spectrum of students who have wide-ranging learning goals, and we all want to help them make as much progress as possible.”
The use of VR offers a colourful palette of opportunities. In addition to practicing conversations and presentations and virtually travelling to other countries, a student can also bring his own VR material to practice with.
Give a guided tour of your company using VR
“More and more organisations are developing content to provide VR guided tours or 360o photographs, which we can use when students are with us. Give a guided tour of your company in German or French! Most of our students come for business training and want to learn to communicate in a foreign language for their specific business needs. VR can make that all the more life-like," says Katharina Stoll.
Do you want to learn a language using VR?
Do you also want to improve your language skills using virtual reality? Then simply contact us to arrange a personal meeting with one of Regina Coeli’s language trainers. | <urn:uuid:bd7fea9f-38f5-4a6c-95e9-ee8ca83f962d> | CC-MAIN-2022-33 | https://www.reginacoeli.com/blog/learn-a-foreign-language-with-the-nuns-using-virtual-reality.html | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.954811 | 815 | 2.84375 | 3 |
Previously Published on Express.co.uk – MORE and more people are affected by diabetes each year. The condition, that affects the body in a number of ways, can be difficult to manage and to treat. Furthermore, a number of factors can increase or decrease a person’s risk of the condition, and coffee is one of them. Read on for some interesting health benefits of coffee.
Around five million people in the UK have a form of diabetes. The most common type, making up around 90 percent of cases, is type two. This form of diabetes occurs when the body does not produce enough insulin, or the cells in the body do not react to insulin. Type one, meanwhile, accounts for the other 10 percent of cases.
Several factors can increase or decrease a person’s likelihood of developing the condition. Including how much coffee they consume. While the initial assumption may be that coffee could increase a person’s risk of type two diabetes, in fact the opposite is the case.
According to a study from Harvard University people who cut their coffee consumption by one cup a day over a four-year period were 17 percent more likely to get diabetes. Furthermore, those who added an extra cup reduced their risk of developing diabetes by 11 percent. Although the researchers don’t know quite why coffee has this effect on the body, one theory that exists is that the act appears to promote steadier blood sugar levels. While this means coffee has a beneficial impact on the body, not all coffees are equal. An espresso or cafetiere is likely to have much higher health benefits than a coffee with sugar, whipped cream, and syrup.
Health Benefits of Coffee
- Nevertheless, it is yet another health benefit of coffee to have been identified.
- Previous studies have found the coffee can help reduce the risk of heart disease.
- Meanwhile, there are other factors that can affect a person’s likelihood of developing diabetes.
- According to Prevention using mouthwash can have a negative impact.
A study from the University of Alabama showed those who used the substance twice a day were over 50 percent more likely to be diagnosed with type two diabetes than those who didn’t use it. Although this may sound unnerving, more research is needed to fully understand this link. Diabetes UK says a number of factors can influence a persons’ risk such as:
- High blood pressure
- Gestational diabetes
- Polycystic ovary syndrome
- Mental health conditions.
As each year passes scientists are developing a better understanding of diabetes and how to treat it. In recent years new treatments have been trialled and developed, some with highly positive results. This includes the use of ultrasound and the development of an artificial pancreas. If you’re concerned that you have the symptoms of type two diabetes talk to your GP.
Previously Published on Express.co.uk | <urn:uuid:5e809d61-8eee-4587-a402-2ce4b298bc5c> | CC-MAIN-2022-33 | https://diabetesknow.com/coffee/cutting-down-on-coffee-consumption-could-raise-risk-of-diabetes/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573540.20/warc/CC-MAIN-20220819005802-20220819035802-00473.warc.gz | en | 0.954497 | 617 | 3.125 | 3 |
Kasabach-Merritt syndrome(redirected from Kasabach Merritt syndrome)
Kas·a·bach-Mer·ritt syn·drome(kas'ă-bahk mer'it),
thrombocytopenia and consumptive coagulopathy developing in a large hemangioma, usually in early infancy.
Farlex Partner Medical Dictionary © Farlex 2012
Kas·a·bach-Mer·ritt syn·drome(kahs'ă-bok-mer'it sin'drōm)
Large, bluish, progressive vascular malformations in extremities. Stagnation of blood in lesions can cause disseminated intravascular coagulation, platelet consumption, and bleeding. Condition usually affects infants; sudden growth of lesion causes depletion of platelets. Mortality rate is around 30%.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
Kasabach,Haig H., U.S. physician, 1898-1943.
Kasabach-Merritt syndrome - capillary hemangioma associated with thrombocytopenic purpura. Synonym(s): hemangioma-thrombocytopenia syndrome
Merritt,Katharine Krom, U.S. pediatrician, 1886–.
Kasabach-Merritt syndrome - see under Kasabach
Medical Eponyms © Farlex 2012 | <urn:uuid:db40b271-f08a-4b07-993b-c6851861c183> | CC-MAIN-2022-33 | https://medical-dictionary.thefreedictionary.com/Kasabach+Merritt+syndrome | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573104.24/warc/CC-MAIN-20220817183340-20220817213340-00473.warc.gz | en | 0.789286 | 314 | 2.53125 | 3 |
When you’re online, you are using a computer or other device that’s connected to the Internet. If someone asks if you’re online, they’re wondering whether you have Internet access.
You might say, “I need to go online and check my email,” or “I don’t know if she’s still meeting me — she hasn’t been online all day.” Or you could describe something that’s available or readable on the Internet, like a news story, as being online. While the adjective officially describes a connection to any computer network, it’s almost always used these days to mean “on the Internet.” The word online has been around since 1950.
connected to a computer network or accessible by computer
on a regular route of a railroad or bus or airline system
being in progress now | <urn:uuid:73bafc65-2b3c-4874-8a43-f3059e15af01> | CC-MAIN-2022-33 | https://sarkariexam.io/online/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.911433 | 187 | 3.140625 | 3 |
Makuake is one of Japan’s largest crowdfunding platforms. It was spun out of CyberAgent in 2013 with Ryotaro Nakayama (or Naka as his foreign friends call him) as CEO.
Crowdfunding has taken off more slowly in Japan than it has in the US, and it has followed a different growth path. It started out primarily as a way to raise money for charitable causes and at the moment crowdfunding seems to be having a more significant impact on corporate Japan than on smaller Japanese ventures.
Of course, things are changing fast. More and more creative individuals are taking advantage of crowdfunding platforms, and last year the Japanese government amended the law to allow new ventures to raise capital via crowdfunding.
So perhaps we should say Crowdfunding in Japan is not only about startups
Show Notes for Startups
- Ryotaro’s journey from driver to CEO
- Why price is not that important if you have the right product
- How crowdfunding began as a social movement
- The unique quality demands of Japanese consumers
- Vetting projects — in person — to prevent scams and failures
- Why crowdfunding will be even more important for corporate R&D
- How VCs use crowdfunding to find new companies
- Why so many creatives are leaving big Japanese companies and what it means for the future
Links from the Founder
Transcript from Japan
Welcome to Disrupting Japan straight talk from Japan’s most successful entrepreneurs. I am Tim Romero and thanks for listening.
Today, we are talking about Crowd Funding. Now, Crowd Funding has grown more slowly and somewhat differently in Japan than it has in the U.S. The basics are the same of course. Large numbers of people pledge small amounts of money to charitable causes to support them.
Innovative projects to get early access to the finished product, and to new companies to get a small slice of the equity.
Ryotaro Nakayama or Naka as his English speaking friends call him is an entrepreneur. He started working at CyberAgent as a driver. Eight years later he managed to convince his employer to create a Crowd Funding Platform called Makuake. Then to spin it out as a separate company with him as the CEO. It is an interesting journey.
We also talk about how Crowd Funding is at least at the moment benefiting the larger Japanese companies. We also discuss how that is going to change in the future, and how that might lead to a larger shift in Japanese society. One that could very well lead to a start-up renaissance here.
I will let Naka tell you all about that.
Tim: I am sitting here with Ryotaro Nakayama of Makuake, a Japanese Crowd Funding Platform. Thanks for coming in and talking to us today.
Naka: Thank you for inviting me.
Tim: Now Naka. We were talking before about how Crowd Funding is just getting started in Japan. How it might change a lot of things here. Before we get into Crowd Funding in particular. I think the story of how Makuake came to be is very interesting.
You were kind of an entrepreneur, right. You had worked for CyberAgent. You created this Division and they spun it out into a new company. Why don’t you just tell us a little bit about that process.
Naka: Well, first of all when I was 23-years-old, 2006 I joined to CyberAgent. First, my job was Assistant of CEO.
Naka: CEO’s driver.
Tim: Okay, that is a good job. At least you are connected to powerful people.
Naka: The reason why I got this position.
Naka: I selected this position. I was not interested in actual internet. The things that I wanted to do is to create my new company. Being beside of CEO that is the best way to learn how to create a company.
Tim: Did you just approach the CEO and say hey I have this crazy idea for a new company? You should fund it.
Naka: No. . That time I couldn’t get any funds from my CEO. The next job is to create new business inside of CyberAgent.
Tim: You created a Division within CyberAgent.
Naka: Just Division. . This Division was accumulating site.
Tim: A site to help people manage their loyalty points?
Naka: Yes. Where people buy, they can get the point more than usual purchase.
Tim: Then what happened to that Division?
Naka: That Division became very profitable Division. I get many awards from CyberAgent.
Tim: Right, right.
Naka: Thanks to this experience I got the chance to go to Vietnam as a Venture Capitalist.
Tim: Okay. I guess in that way you get exposed to a lot of different kinds of companies, and a lot of different types of businesses very quickly.
Naka: That was very lucky for me.
Tim: Yeah. Then did you just go to your venture partners, and say I have a perfect investment for you?
Tim: For me.
Naka: Living in Vietnam I did not see many Japanese products product. I saw a lot of Korean product and the Chinese Product.
Tim: What was the reason? Just cost?
Naka: It was not cost.
Naka: Apple iPhone sells for $300 U.S. dollars. People borrow to buy iPhone.
Naka: That costs around $1,000 U.S. dollars.
Tim: Yes, everybody wants to buy an iPhone. .
Naka: I think they borrow from their friends or parents.
Naka: To buy an iPhone. The reason why Japanese product cannot compete is not cost. Japanese companies do not create the things that people want to buy. That is the biggest reason I guess.
Tim: Hmm. How did that idea lead you to create the Crowd Funding site?
Naka: By using Crowd Funding site product maker can try to create the things that they are not have confidence.
Tim: You were thinking of it more as a way for large companies to test new products and gain marketing information rather than as individuals trying to fund their own projects?
Naka: Yes. In Japan, there are so many huge very famous Hardware Companies.
Tim: From the time you joined CyberAgent as an Assistant to the CEO to the day you got funding for your new Crowd Funding Company. How long did that take?
Naka: 7 years.
Tim: Okay. Well, you were certainly paying your dues inside the company with different projects and understanding different sections. Let’s see, you launched it about 2 years ago, right?
Naka: 2 years ago, yes.
Tim: Why don’t you tell me a bit about your customers. What kind of companies are using Makuake?
Naka: Of course, the individual product maker using Makuake also. Huge company started to use Makuake, for example Sony.
Tim: It is interesting in the difference between Crowd Funding in the States and here. In the States, there has been some big companies using Kickstarter and Indie Go-Go as P.R. In Japan, it seems that big companies were the early adopters. What’s the big advantage to the large companies?
Is it marketing? Is it P.R.? Is it Product Development? What do that get out of it?
Naka: The biggest reason is Test Marketing.
Naka: They want to get the opinion from the user by using Crowd Funding.
Tim: They will launch a project not under their own brand, but kind of a stealth.
Naka: Some project is like that.
Naka: Because if they put on the runway users start to buy because of that brand. Imagine about Apple. Even this beer. .
Naka: People call it Apple Beer. .
Tim: People will buy anything with the Apple on it.
Tim: That’s true. It’s a more honest way of test marketing. In fact, Sony. You mentioned Sony . Sony famously last year in America launched the Mesh Product on Indie Go-Go.
Tim: Before that, their very first experiment was on your platform, right?
Tim: What was it? Was it a watch? What was the project?
Naka: First project was an E-paper watch.
Tim: An E-paper watch.
Naka: Called the MEIS watch.
Tim: What happened with that project? Did Sony turn it into a new product with the Sony brand?
Naka: They don’t have any plan to put their brand to this product. They want to create a new brand.
Tim: In Japan it seems that Crown Funding is being used mostly by large companies for Test Marketing. On the customers side, what people are using your platform and buying these products?
Naka: Users tend to be people who want to get new exciting products.
Naka: They don’t care whether the creator is individual or big company. The important thing for them is the creator is very high quality creator.
Tim: On the customer’s side it sounds very similar to the customers for Crowd Funding in America. It’s so far most of the really big hits from Crowd Funding have been Japanese who have used Kickstarter or Indie Go-Go.
Tim: Is it starting to take off among individual makers here in Japan?
Naka: Last year, Japanese creator started to use Crowd Funding in Japan. It was very difficult for them to use the Crowd Funding Platform.
Naka: Because of the language. This is the biggest reason they want to use Japanese Crowd Funding.
Tim: It would seem since the large companies are not using their own brand. It would be very easy for individual creators to compete fairly.
Naka: Even big company doesn’t have big value to create thinks at first time.
Tim: Well yeah, being able to raise funds. Being able to get budget helps you if you are an individual with an idea, or you are the head of a division in a company. . Everyone is trying to funds one way or another.
Naka: Because I was a Venture Capitalist I can understand the situation outside of the big companies, totally new entrepreneur can get more big funds from the Venture Capitalist to their business. The Sony subsidiary companies, or as a big company inside of business.
Tim: . That’s an interesting point. Well, certainly I today’s funding environment.
Tim: I guess it is easier for individuals to raise money with a new company and a new idea than it is for people inside of a big company to get funding. .
Tim: I had not thought of it that way, but that is an interesting point.
Naka: Even the project inside of the company, not directly. They can easily use very weak amount of the project.
Tim: Right. I remember 3 or 4 years ago when Crowd Funding was clearly becoming successful overseas. A lot of people were very skeptical about Japan. They were just saying that it was suitable for Japan. What do Japanese consumers really expect from Crowd Funding? Japanese consumers are famously hard to please and care about quality, and care about things being exactly right. Has that been a problem for you as you have grown?
Naka: Not only me, but also any Makuake Crowd Funding user in Japan. Want to get the very new and very exciting, very innovative product. Japanese Crowd Funding Platform started as charity site.
Tim: That’s right. The first ones were charities for the Earthquake.
Naka: Yes. Many Japanese users image of Crowd Funding is charity site.
Naka: That was a very big hurdle for us to create the creative Crowd Funding Platform like Kickstarter and Indie Go-Go.
Tim: Right, right, right.
Naka: Many high quality creators didn’t notice that Crowd Funding is for them.
Tim: One of the things that overseas platforms had trouble with has been products that have not been delivered, products that the founders couldn’t make for example. Have you run into those problems in Japan and how did you solve them?
Naka: One thing I can say is Japanese creator has a very big responsibility for their product compared to foreign countries, so that Japanese product quality is a number one quality. Japanese creator has pride.
Tim: In a sense I guess you are saying yes the Japanese customers are very demanding about quality.
Tim: That’s matched because the creators are also very demanding about quality just as much.
Naka: Mm-hmm. You know many Japanese are not good at presentation over here.
Naka: So that many creators presentation is lower than actual quality.
Naka: . The final product tends to be better than the presentation was. .
Tim: Okay, so they under promise and over deliver.
Tim: That’s a happy situation for everybody. How are you planning on handling the things as it grows? For example, Indie Go-Go has had products that were almost scams. Like they had a Heal Bee last year that raised like about a million dollars. Are you concerned that as your platform gets more and more popular that there will be either people trying to sell low quality products, or outright scams? How are you going to stop that from happening?
Naka: Before the project, I put it on Makuake. We checked in the interview with a creator. We checked, they have an ability to create their idea or not.
Tim: You actually check their backgrounds. You talk to them on the phone over IM. How do you vet them? How do you check them out?
Naka: About all of project creator we meet directly.
Naka: Yeah, face-to-face.
Tim: Oh okay.
Naka: People who definitely being in Tokyo or near by Tokyo at least we call and talk with telephone or Skype.
Tim: That’s a very interesting approach. I mean so in a sense. Well, sometimes it is important to do things that don’t scale. Really Crowd Funding Platforms, or any platform is based on trust. I guess you are really trying to insure that Makuake is a trusted platform. Even if it means you grow more slowly.
Naka: The most important thing is platform should be very trustful platform. We very carefully check the creators .
Tim: About what percent do you say no sorry you can’t list on my Makuake?
Naka: It is around 30 percent, is a very low quality creator that cannot create the idea. Twenty percent they need brush-up.
Tim: You have 30 percent that just aren’t ready to use your platform.
Tim: Twenty percent that need brush-up and 50 percent that are okay. For the 20 percent that need brush-up do you help them and give them advice about how to use your platform and run a good project?
Naka: Yes. We advise how to use Crowd Funding into the creating we want. How much goal should be. Something like that.
Tim: How many projects are active? How many projects did you run last year, or how many projects are active right now? So, we get a sense of size and scale.
Naka: Today, around 200 projects is running in Makuake.
Naka: One project tends to be around 2 month project. One month around 100 projects is starting at this time.
Tim: What percentage of those end up fully funded and making a product?
Naka: In terms of this very hard to say. I can say around 50 percent projects can get fully funded and reach the goal. We have two courses. One course is like Kickstarter.
Naka: The other thing is maybe Indie Go-Go, flexible Course.
Tim: Okay. You can bet people get paid whatever goes in. Fifty percent are fully funded, and the other 50 are partially or?
Naka: The important thing is the ratio or success rate environment or the most fear to try everything is very important thing for Crowd Funding Platform. Because 100 percent project can success. Really, I hesitate to use Crowd Funding. If my project, only my project fails. .
Tim: Certainly the large companies. I bet the attitude about what is failure is changing. Because it sounds like a lot of these big companies are looking for feedback and information. Even a failure, it still is far cheaper for them to find out that the market does not want this product using Makuake. Than it is using traditional market research and study groups. Even the failures are really failures in some cases.
Naka: People’s failure, say to ask they are happy to use this because they can understand what matter. What the user is thinking about in a product.
Tim: It gives them a direct connection to customers that they can’t have any other way right now. I am sure they are delighted to use it. One thing I am curious about, so Japan in general both consumers and business are very conscious of brands and trends and hierarchies. How do you break through this? Right now your customers are mostly people who are super early adopters. They are people who want the latest cool thing. That even in Japan is kind of a small group. Do you plan on being able to break out of that and to have a larger audience, or are you really trying to stay focused on these new super early adopters?
Naka: It is going to be very difficult to get up to the majorities.
Naka: Yes. Gradually we should try to ask makers to use Crowd Funding when they create new products.
Naka: Yeah, step-by-step.
Tim: Do most people who are starting a project, do they bring their own funders and do their own marketing? Is there a pool of people, a pool of Makuake fans who invest in lots of different projects?
Naka: Maybe, 30 percent of the backers from Makuake users.
Naka: The other comes from maybe promotions.
Naka: That’s kind of promotions can send user to Makuake.
Tim: Of course, every project is different, but in general about 30 percent are the core Makuake fans looking for new things and about 70 percent is the product team marketing and articles written about it coming in.
Naka: What creates Makuake’s P.R. Marketing is very unique things.
Tim: Okay, tell me about that then.
Naka: Makuake has a very good P.R. Team. Their quality is almost number one in entire industry I guess.
Tim: Well, the CyberAgent connection. I am sure it helps quite a bit there.
Naka: Yes, very useful. The team has a relationship to many medias.
Naka: So that which medias is suitable to this project. They introduce the project to public media and of course the media writers all like this project.
Tim: Is this the P.R. Service? I guess it is an optional service that the projects can use.
Naka: Yes. That is a freebie.
Tim: You don’t charge for it.
Naka: Yeah, we don’t charge.
Tim: Right now, what is the most popular kind of projects on Makuake?
Naka: Same as U.S. Hardware.
Tim: Internet things.
Naka: Yeah. IoT, we usually say I.O.E.
Tim: Internet of Everything. .
Tim: Okay. . Yeah, sure. I think outside of Japan most of our listeners won’t know about CyberAgent. They are in Japan a very powerful and innovative force in the, well mostly online internet space.
Tim: They have been branching out into Venture Capital and quite a few other things. You sister company, CyberAgent Ventures. Have they invested in companies or projects they found on Makuake?
Naka: Happily, last month or 2 months ago the one sort of company can get venture funding from CyberAgent Ventures after they used Makuake Crowd Funding Platform.
Tim: Awesome. What do they make? What’s the company?
Naka: That start-up is making their platform for Haircut Stylists.
Tim: For Hairstylists.
Naka: Cut models.
Tim: It’s a platform for Hairstylists and for Cut Models. People to practice on.
Naka: Yes, people –.
Tim: Yeah, I never thought about it. I guess you need people to practice on. .
Naka: Very specific industry.
Tim: Yeah. That is a vertical.
Naka: Yes. You know to get to professional position Hairstylists Training to do Cutting.
Tim: Sure, they have to practice I’m sure.
Naka: Then they need a huge amount of hair. .
Naka: Opposite side, people want to cut their hair.
Tim: Yeah. They are matching up Hairstylists who want to cut hair with people who want free haircuts.
Tim: And, are willing to take a chance. .
Naka: That’s right. Of course, after finish. The professional haircut stylist can train.
Tim: Yeah, double check and fix anything if there is too much. You know I love businesses like that. It never occurred to me before, but yes obviously that is a matching service. What was their product on Makuake?
Naka: They applied to Crowd Funding to create their service site.
Tim: Oh okay. They were Crowd Funding for the product itself.
Naka: Yes. Very, feed, feed, feed the funding around I remember $3,000 U.S. dollars because they was a University student.
Naka: Going to University and creating their start-up. They don’t have any money. Given they don’t have any money, so that they should use Crowd Funding to create their first product.
Tim: Right. I am going to ask you to predict the future here. Crowd Funding is still very new in Japan. It’s growing rapidly. It started out for charities, social causes. It is now being used a lot for projects and artistic work. Just last year the Japanese Government changed the law allowing companies to raise equity using crowd funding.
Over the next 5 to 10 years what do you think Crowd Funding in Japan is going to look like? What are the changes we are going to see?
Naka: I think the Kickstarter like the Makuake continue growing by being used from many product creators.
Many big hardware companies employees starting to quit their company to create a new start-up.
Naka: Sometimes they must wait. There are so many creators this time from now. The number of the independent creator is increasing.
Tim: This is something when I travel to the U.S. and Europe. The image of Japan is as a non-creative country. In truth, there is amazing amounts of creativity in Japan. I think the problem Japan has always had is it’s very difficult for that creativity to kind of bubble up and get exposure. You are saying that Crowd Funding is perhaps the best way for that creativity to bubble up and get exposure now.
Naka: Mm-hmm. Encouraging their creators by funding. The number of creators should be increasing I guess. As I said, there are so many big successful hardware makers in Japan.
Naka: Recently, people quit their big hardware companies starting to join to the hardware ventures. Almost every hardware venture in Japan has people who have experience to work in Sony and Hitachi and Toshiba, so on. Either independent or start-up companies has ability to create very good hardware or –.
Tim: They understand quality control and outsource process.
Tim: I think the flipside to that though is that a lot of the creative talent that companies like Sharp and Pioneer and Sony have not really been treated that well over the last 30 or 40 years. If this trend continues I think it is going to cause some of the large Japanese companies to change the way they treat employees. To treat these people better to prevent them from going out and starting their own companies and leaving.
Naka: On the other hand of the start-up situation the big company starting to create the startup Division.
Naka: Sony started to have innovation division to create new product. Many employees of Sony started to create new products. One of them is Mesh, as you said.
Tim: The watch.
Naka: One of them is a Face watch. One of them is Smart Watch and Sony create a new company to create new products that use Sony Technology.
Naka: coming from outside of Sony that the companies can use Sony Technology.
Tim: The big companies are reaching outside of themselves to find creative talent.
Naka: I guess many big companies should imitate this kind of way to create.
Tim: This is a big change for Japan. Traditionally, I mean forever basically in Japan big companies had their own RND staff. It was highly secretive. The whole concept of open innovation is still kind of mistrusted here.
Tim: This is a big step, and I think a good done.
Naka: Yes. I think the only way to survive is very competitive hardware era in a Japanese Company should try to create new products as many as possible.
Tim: You think that even the larger companies will try to create more and faster and smaller batch?
Naka: Yes. Maybe this should be quarterly start-up I guess.
Tim: I think so. The lean start-up I am always amazed people don’t know this. The lean methodology was invented by a large Japanese Corporation. The lean methodology, you didn’t know that.
Tim: Toyota invented lean.
Tim: Everything kind of comes full circle.
Naka: Yes. When the Crowd Funding is one of the best way to do really development I guess.
Tim: Before we wrap up is there anything else you want to tell our listeners about Crowd Funding, or the future of Japanese innovation?
Naka: Many of your listeners are Japanese, so please wait very innovative products from Japan, not Apple. .
Tim: I think there are amazingly innovative products coming out. I think that is a wonderfully optimistic to wrap up on. Thanks for sitting down and talking to me.
Naka: Thank you.
Tim: All right.
And we are back.
The amount of effort that Makuake invests into insuring that projects are valid, and that the end result is high quality is really impressive.
It really should not be that surprising to anyone who has done business in Japan for a long time. Still though, meeting their creatives face-to-face as part of their due diligence was something that I had not expected.
Then quality and trust really are everything in Japan. Growing more slowly, doing things that don’t scale. Doing it in a way that allows you to maintain quality and trust makes a lot of sense here.
I also found it interesting that the quality equation cancels out I that the exceptionally high quality demanded by Japanese consumers was balanced out by the exceptionally high quality bar that Japanese makers set for themselves.
The other key takeaway from this, and we will explore this in detail in an upcoming podcast, is the migration of top talent from Japan’s manufacturers into small start-ups.
There are a lot of Hardware start-ups here that are staffed with people of decades of real world hardware development and production experience.
No matter what country you live in you will be hearing a lot from these founders and their companies in the near future.
Now, if you want to see the links and the information that Naka and I talked about during the show, or to get in touch. Go to DisruptingJapan.com/show 019. You will find all of that and much, much more in the resources section of the post.
If you have got an interesting Crowd Funding experience or are thinking of giving it a try, drop by the site and let us know what you think about it. We would love to hear from you.
If you get a chance please leave us an honest review on iTunes. That is really the best way you can help support the show and get the word out.
Most of all thanks for listening. Thank you for letting people interested in Japanese start-ups know about the show.
This is Tim Romero and Thanks for listening to Disrupting Japan. | <urn:uuid:b801e40c-f0c0-4a9a-85dc-ef97826a53c8> | CC-MAIN-2022-33 | https://www.disruptingjapan.com/crowdfunding-in-japan-is-not-about-startups-ryotaro-nakayama/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573540.20/warc/CC-MAIN-20220819005802-20220819035802-00473.warc.gz | en | 0.965863 | 6,309 | 1.742188 | 2 |
Radiation Hardened 12-A synchronous buck regulator claims industry’s highest output current
The ISL70002SEHVF is a Single Event Effect (SEE) immune regulator, featuring high dose rate (HDR) and low dose rate (LDR) immunity. Its high level of integration eliminates the need for external components, reduces cost, board space, and provides the industry’s highest reliability for space and harsh environment applications. Additionally, the ISL70002’s Class V compliant hermetic solution meets the most stringent satellite program requirements.
The device’s maximum junction temperature of 150 degrees C allows designers to take full advantage of the ISL70002’s output power while synchronous rectification provides higher efficiency than standard buck regulators, especially at lower output voltages.
A current sharing capability supports paralleled regulators and the device is designed for complete single event immunity at LET = 86.4 MeV. The device is SEL, SEB, SET, and SEFI hardened.
Two ISL70002s can be paralleled to support output currents up to 19 A (@ 150 C junction temperature), making this the ideal power solution for FPGA-based designs. Only one bias rail is required, simplifying system power architecture design by eliminating an additional regulator or FET to step the voltage down to less than 4.5 V.
Availability and Pricing
The ISL70002SEH is currently available in a 64-lead ceramic quad flat pack package, with sample pricing starting at $602 each in 100-unit quantities.
More information about ISL70002SEH point-of-load synchronous buck regulator at | <urn:uuid:f7f015a2-b691-47af-9725-dfc5625559ed> | CC-MAIN-2022-33 | https://www.smart2zero.com/en/radiation-hardened-12-a-synchronous-buck-regulator-claims-industrys-highest-output-current/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573540.20/warc/CC-MAIN-20220819005802-20220819035802-00473.warc.gz | en | 0.858782 | 359 | 1.59375 | 2 |
SPINAL MANIPULATION: A Beneficial Choice for Relief of Back Pain, Better Quality of
Life, Reduced Risk of Tests and Prescriptions
Spinal manipulation therapy (SMT) is a choice for treatment of back pain, a choice
not all back pain sufferers know about but may
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West Palm Beach CHIROPRACTIC TIP OF THE
MANAGE OSTEOPOROSIS: Risk, Falls, Care
Osteoporosis-related falls are widespread
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In women, a recent fall signaled an 8.1%
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your West Palm Beach chiropractic appointment with Chiropractic Care now! | <urn:uuid:0608634e-0bc5-4655-91bd-818b9b6bd6e3> | CC-MAIN-2022-33 | https://www.coxchirocare.com/doctor/chiropractor/chiropractic-West-Palm-Beach/chiropractic-resources/healthy-news-july-2022-spinal-manipulation-benefits-and-osteoporosis-management | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573540.20/warc/CC-MAIN-20220819005802-20220819035802-00473.warc.gz | en | 0.889507 | 784 | 1.507813 | 2 |
Carbon PCB Prototype
Carbon printing oil refers to the use of screen printing technology, printed on the PCB board designated position of carbon oil, after the oven curing test OK to form a qualified carbon film with a certain resistance value to replace the original resistance element. The production is similar to the character screen printing, except that the carbon oil has good electrical conductivity, and the character is a semiconductor material, only plays the role of marking and welding.
PCB Production Capacity
1, carbon oil clearance because of carbon oil has good conductivity, so the finished product plate has a certain gap of carbon oil required to ensure that do not short circuit, usually require product minimum eight mil clearance gap(HOZ ), 12 mil clearance gap (1-3 oz copper), if the production film can increase the gap, the gap as far as possible to increase the finished product to ensure no short circuit.
2. Minimum alignment tolerance of carbon oil: +/-6mil
3. Size of carbon oil window and the gap with copper PATTERN: considering factors such as alignment tolerance and oil infiltration, carbon oil PAD single side needs 6mil (HOZ base copper) and 8mil (1-3oz base copper) larger than copper PAD to ensure no copper exposure. Correspondingly, the gap between the carbon oil window and the surrounding copper PATTERN also needs to be 6mil (HOZ base copper) and 8mil (1-3oz base copper), so as to avoid the carbon oil covering the surrounding copper PATTERN and thus avoiding short circuit | <urn:uuid:0ad51404-9275-498a-93ae-e74d6881f74a> | CC-MAIN-2022-33 | https://www.pcb-hero.com/blogs/lunas-column/what-is-carbon-printed-circuir-board-and-what-is-its-capability | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573540.20/warc/CC-MAIN-20220819005802-20220819035802-00473.warc.gz | en | 0.927311 | 315 | 2.328125 | 2 |
A Comprehensive Beginner’s Guide to Keto
If you are considering making the Keto diet a part of your diet, you are likely wondering exactly what this new diet entails. Fortunately, you are not alone. You are not the only one who has experienced success with this diet. This beginner’s guide will show you how to eat keto friendly meals and lose weight.
What is a Keto Diet?
Whether or not you are familiar with the ketogenic diet may make you wonder what it is. It is a low carb, high-fat diet which uses body fat as its primary energy source. It lowers insulin levels and turns the body into a fat-burning machine. MCT oil enhances ketone production. This type of fat should be included in the diet.
The ketogenic diet allows you eat fatty meats and eggs, as well as fish, cheese, heavy whipping, and grass-fed Butter. Avoid sugary foods including artificial sweeteners. Alcohol is also strictly prohibited, as are many beers and sugary drinks. You might also want not to drink sweeter wines. It is possible to still get enough protein through the keto diet, even if you don’t follow any strict guidelines.
While the ketogenic diet isn’t the most appealing option for everyone, there are many advantages to it. The ketogenic diet helps you lose weight and improve your mood. It also increases energy and mental clarity. For more information on the ketogenic diet, read on. This diet is becoming more popular with dieters because it’s the best option for many people.
Is it worth trying the keto diet?
While the Keto diet can be beneficial for weight loss, there are many drawbacks. Not only can you end up with digestive issues, but also higher cholesterol and weight. You might find yourself craving foods you used to love. This could lead you to reverting to old habits. Your body may not be getting enough fiber and may not function properly without it. The diet is also not very healthy for your gut.
The most common complication of the diet is the possibility of a gastrointestinal disorder called ketoacidosis. This condition can lead to serious health problems. It occurs when your blood pH drops below normal. The good news is that ketoacidosis is very rare in healthy individuals. Ketoacidosis is unlikely to be severe, as ketones do not lower your blood pH.
Get your Keto Recipes Free!
A good beginner’s guide to Keto should be filled with easy-to-follow recipes that are free of carbs, sugar, and other unhealthy ingredients. This will help you stay on track and make you feel satisfied for many days. Sticking to the diet is the biggest problem that Keto users face. You can get support from a group or send them an article to help you overcome this problem. This will help them to stay accountable and motivated to complete their program.
One thing beginners should know is that Keto is not for everyone. There are some restrictions and health improvements that you should discuss with your doctor before starting the diet. You should keep your diet simple and stick to whole, healthy meals. It is not difficult to find a beginner’s guide for Keto. However, it will require some research. There are many keto-friendly recipe options available. Most of them emphasize the importance whole food, protein and healthy fats.
The Ultimate Keto Meal Plan
The Ultimate Keto Meal Plan: Beginner is designed to help beginners understand the basics of healthy eating. These include protein (carbohydrates, fat), and macronutrients (iron, zinc, calcium and phosphorus). The goal is to get a balanced intake all macronutrients. This is a complex formula so it is best to consult a qualified nutritional advisor to determine which foods you should include in your daily meal plan.
A ketogenic diet prohibits most carbohydrate-rich foods, including fruit juices and most starchy vegetables. Cheese is high in fat but not associated with an increased risk of developing heart disease. Because they are low in calories and fiber, non-starchy vegetables are a great choice for this diet. They are also rich antioxidants, which protect your body against harmful free radicals.
The Ultimate Keto Meal Plan For Beginners includes recipes for the morning and evening meals. It includes recipes and meal prep instructions you can download to your tablet or smartphone. The program also contains a complete grocery list. This list is specifically designed for keto dieters. This list will help with weight loss and exercise.
Visit www.claudiacaldwell.com for Best Keto Plan
The 30 Days Keto Plan is an easy-to-follow guide to losing weight while maintaining your ketosis. Claudia Caldwell, a weight loss expert, designed this plan. It includes easy-to follow recipes and a step by step meal plan. The plan is chemical-free and helps to reduce carbohydrate intake.
Claudia Caldwell has her Keto meal plans available for purchase on her official site. The prices for the meal plans start at $67, but they are currently discounted to $27 as part of her anniversary sale. With her meal plans, you can get the Best Keto Plan at the best price. She has been helping people achieve their ideal body for over 20 years, and has seen both the positive effects of the ketogenic lifestyle for herself and for her patients.
Claudia’s 30-Day Keto Plan is a fast and effective way to lose weight. It’s been proven to work and it has been tried by many. It helps you reach ketosis quickly with recipes and meal plans that are both healthy and low in carbs. It has many benefits such as helping to fight cancer, epilepsy or Alzheimer’s.
The first step in achieving a ketogenic diet is learning how to burn fat. We have grown up in a Western culture that eats a steady supply of carbohydrates. Therefore, our bodies are not equipped to burn fat for energy. With a little information, beginners can learn how they can burn fat by reducing carbohydrates and increasing healthy fats. It is important to eat moderate amounts of protein.
What keto diet should you eat?
When figuring out what to eat on the ketogenic diet, a good place to start is by looking at the macronutrient ratios. You should aim to eat between 0.6 and 1.0 grams of protein per pound of lean body mass. If you weigh 250 lbs, you have 75 lb of fat and 175lb of lean body mass. Your daily protein intake should not exceed 105 grams.
The keto diet offers many benefits including a decreased appetite, increased energy, and improved sleep quality. The keto diet has been well-received by those who have tried it. They report feeling less hungry and more energy. This doesn’t happen overnight. It takes around two to seven days for your body into ketosis, which is when it starts burning fat. These symptoms are common in the first few weeks.
A keto diet well-formulated emphasizes electrolytes, mineral balance and a higher intake for green vegetables. This is a good option for athletes who sweat more than others. Exercise and sweat deplete minerals, making it necessary to supplement the diet. Although this plan is more difficult to keep, it can be much easier in the end. Supplementation is an option if you are uncomfortable with eating high-carbohydrate foods.
What to Avoid with the keto diet
There are many foods you can enjoy while on a ketogenic diet. But, it is important to know what to avoid. For example, nuts, which are naturally low in carbohydrates, should be avoided. They have different amounts of carbohydrate, but be careful not too much! You can still eat nuts, but you should limit your intake. Choose non-starchy, healthy nuts. You can also choose a healthier option such as sunflower seeds. Lastly, you should try to stick to drinking water and not soda. Even though you can’t drink coffee or alcohol, you can still enjoy flavored water, including sparkling water. Seltzer comes in a variety flavors.
Moderation is important when eating meat. Meat is a staple of the keto diet. However, it contains hidden carbs as well as sugar. Avoid eating processed meats, as they contain fillers that raise the carb count in your body. Seafood is a great source of protein and fat, but shellfish may contain significant carbohydrates. Talk to your doctor if you are taking medication for hypertension.
What Should You Eat and Drink on a Keto Diet?
You may be familiarized with the Keto diet, and its restrictions. This diet focuses on protein, fat, and limits carbohydrates. Many artificial sweeteners, legumes, and fruits are out of reach. It is also forbidden to consume alcohol, including sweeter wines, sugary cocktails, as well as many beers. So, what should you eat and drink on a Keto diet? These are some helpful tips.
Sugar, despite its name, is a foe of the Keto diet. Many foods are labeled as “healthy,” but they often contain hidden sugar. Refined sugar is not the only type of sugar in processed foods. Luckily, there are several sugar-free sweeteners you can use in place of sugar on the keto diet. Continue reading to learn more about what you should avoid.
Despite its name, the ketogenic diet doesn’t call for a strict zero-carb plan. You can eat as much as 50 grams of carbohydrates each day. While it may seem impossible to stick to that strict diet plan throughout the entire day, you can sneak in a small cheat meal every now and then. One large doughnut or a cup of marshmallows contain about 34 grams of carbs. Although you may feel satisfied with the sweetness, your body can react negatively to excess sugar. This can increase your risk for heart disease, diabetes, and other health problems such as cancer.
It is worth thinking twice about alcohol. While alcohol contains carbohydrates, you’re allowed to drink up to half a glass on the keto diet. You may need to reduce the amount of carbs you consume by substituting Greek yogurt for fruit or other healthy options. However, alcohol can make it more difficult to lose weight because your body must first burn alcohol calories, before fat calories. If you want to drink alcohol, make sure you opt for a low-carb variety.
There are many reasons honey should be avoided when following a Keto diet. Honey, even though it may be well-respected, is high carbohydrate. Other natural sweeteners also follow the same pattern. These include molasses, maple syrup, coconut sugar, and agave syrup. Avoid sugar alcohols, such as sucralose or erythritol. These sweeteners do not fit into the keto diet.
Some people dislike honey, so you might want to try a keto-friendly substitute. These low-carb sweeteners will give you the sweetness that you desire, without compromising your keto diet. Also, dietician Abbey Sharpe warns against artificial sweeteners. Instead, she recommends that you use honey from your local area. There are many other benefits to using honey as a sweetener. Honey is naturally sweet and has many health advantages, so don’t be afraid to try it.
The sweetness of monk fruit is 200 times sweeter than sugar. Monk fruit extract can be naturally sweetened with sugar, but manufacturers sometimes add sweeteners to their products. This increases the calorie content and can contribute to metabolic syndrome, a precursor to diabetes and other diseases. Honey is a sweetener, but it contains fewer calories than sugar. Monk fruit extract can be substituted for honey. You should be cautious when purchasing monk fruit extract.
Maple syrup should be avoided
Many people worry that maple syrup is out of bounds for Keto dieters. Although maple syrup is sweeter than most syrups, it still has a higher carb count than most other syrups. Unlike coconut sugar, which has few carbs, maple syrup contains a high amount of total carbs. Maple syrup is a healthier option to regular table sugar, but it does contain vitamins, minerals.
While maple syrup’s glycemicindex is lower than other sugars it can cause digestive discomfort. To make the sweetener keto-friendly, it should be in powder form. You can flavor it with maple extract. It should be used sparingly as it may make your sugar-free syrup gritty. You should consult your doctor if you are uncertain about maple syrup’s suitability for the Keto diet.
You can substitute maple syrup for sugar-free alternatives. A low-carb substitute is glucomannan, which melts in hot liquids to create the ideal syrup consistency. Maple extract can be used instead of maple syrup. Maple extract tastes similar to maple syrup. It can also be mixed with vanilla for the same effect. Xanthan gum thickens the syrup and gives it the same mouthfeel that maple syrup.
Avoiding gluten-free breads
Whether you’re following a low-carb or low-gluten diet, you might be surprised to know that most grains contain gluten. Gluten proteins, which are found in wheat, rye, and barley, are responsible for dough’s chewiness and sticky texture. Although wheat naturally contains gluten it is also added to bread and pizza. Gluten helps foods stay together by binding and increasing their volume. It can also have a negative impact on your health.
If you are following the keto diet, it is important to avoid pizza, pasta, and bread. They contain gluten. While it might be tempting to skip gluten-free breads and pasta, these items are unlikely to have the same nutritional value as those made with wheat flour. If you are concerned about wheat allergies, cereals may be a good option. They often contain gluten-like proteins. You should also avoid processed meats, alcohol and cheese.
Many people mistakenly believe that gluten-free pasta and breads contain no carbs. While this is true for products with a gluten-free label, it doesn’t necessarily mean that they are keto-friendly. Even with a label, many of these products still contain high levels of carbohydrates. The gluten-free version could contain wheat-alternatives such potato starch or modified starch. These are also high-carbohydrate foods that can help you get out of ketosis.
You may be wondering if you can include beans in your keto diet. Beans are high in carbs, so technically it is possible. A cup of beans provides approximately half of your daily allowance. For this reason, you may want to consider other beans that are suitable for a ketogenic diet. You may be unsure whether you should include beans in your daily meal plan. Read on to learn more.
Beans are a staple food that is rich in nutrients and fiber. Beans contain both soluble and insoluble fiber. Insoluble fiber is used to regulate blood cholesterol levels by binding to cholesterol in your food. Insoluble fiber attracts liquid and is vital for cellular function, weight regulation and cell function. Both of these fibers promote regularity. As a result, beans are an excellent choice for those following a ketogenic diet. They are also gluten-free.
Beans are generally not allowed on a keto diet. However, there are some beans that can be eaten on low-carb diets. Soybean has only 2.3g per 100g of net carbohydrates. Other beans such as Green beans or Lupins have 10g to more net carbohydrates per 100g. Ketosis’ biggest enemy is beans because they have almost no fat.
When following a Keto diet, you should limit your fruit intake, but you don’t have to completely cut out fruits from your diet. Many fruits are incredibly healthy and nutritious. Even though they are not in season, you still have the opportunity to enjoy them throughout the year. Here are the top fruits you should include in your Keto diet. You might be amazed at the fruits you find. You’ll be amazed at the variety of fruits you can eat.
Apples have only 25g of carbs per cup, making them the most carbohydrate-rich fruit. Strawberries contain half of your daily carbohydrate limit, and are high in fiber. Strawberries are a better choice than other fruits like strawberries. These fruits can be tried occasionally depending on your sugar tolerance. Strawberries are one the best fruits to eat when you’re on Keto. Try some strawberries to help you decide.
You can have a cup or two of coffee, but avoid sugary drinks. Although some beverages are high in fiber, too many carbohydrates can make it difficult to follow the keto diet. Sweetened tea, sports drinks, soda and soda all have added sugar so they are not recommended for the Keto diet. Regular water is the best way for keto to stay hydrated. You can even substitute your sweet drink with unsweetened or sparkling water.
Avoid processed snacks
Avoid snacking on processed foods while on the keto diet. These foods are often full of sugar and carbs, despite the appealing flavor. While beer and wine can be enjoyed on a low-carb diet it is best not to consume them. Similarly, starchy vegetables, such as potatoes, corn, and beets, contain more carbs than fiber. Avoid high-sugar fruits such as bananas and apples. These can spike blood sugar much faster than vegetables, protein, and vegetables. Instead, choose plain yogurt and Greek yogurt. These two types of yogurt have fewer carbs than regular yogurt.
It is best to reduce snacking while on the ketogenic diet. Avoid processed snacks completely and eat only two real foods at meals. You will be able to curb your snack cravings and delay your next meal by eating a full meal. By delaying the feeling of hunger until the next meal, you are training your body to be able to fast and keep fat stores full. You can also replace your snack with scrambled or boiled eggs. These are quick and easy to make and won’t break your Keto diet.
You should avoid fruits and vegetables as well as foods that contain wheat gluten or products made with these ingredients. You should also avoid refined foods like white bread and BPA-lined containers. Factory-farmed pork should be avoided as it contains mercury and omega-6 fats. Additionally, you should avoid eating seafood, because the fish may contain PCBs and mercury. | <urn:uuid:b92ffa57-5140-4a76-87f0-f7ca682f97ef> | CC-MAIN-2022-33 | https://www.nativeamericainc.com/macs-pork-rinds-keto/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573540.20/warc/CC-MAIN-20220819005802-20220819035802-00473.warc.gz | en | 0.948859 | 3,840 | 1.726563 | 2 |
Electronics giant ABB has secured a contract with Spanish shipbuilder Astilleros Gondán to supply an electric power solution for urban passenger ferries that will operate on Lisbon’s Tagus river.
The ten new ferries will be operated by the public ferry company Transtejo on three key routes linking Lisbon to Cacilhas, Seixal and Montijo on the south bank of the Tagus, and will enter service between 2022 and 2024. Each 40-meter ferry will carry up to 540 passengers, and will have a maximum speed of 17 knots.
In addition to energy storage, ABB will deliver an electric power solution and an integrated marine and propulsion automation system. Each ferry will be powered by battery packs with a total capacity of 1,860 kWh. ABB’s Onboard DC Grid power distribution system ensures that the battery output is delivered to the ferry’s subsystems in the most optimal way. The overall power setup is controlled by ABB’s Power and Energy Management System, which is designed to increase fault tolerance and provide a high degree of reliability while ensuring the maximum lifetime for the batteries.
ABB estimates that converting the ferries from diesel to all-electric power will eliminate about 6,500 tons of CO2 emissions every year.
“Cutting greenhouse gas emissions are top priorities in urban planning. Today, the technologies chosen for fast ferries operating so close to the heart of the city must be clean and green,” said Antonio Pacheco of Astilleros Gondán. “ABB has been selected both on the grounds of energy efficiency and its extensive experience in delivering all-electric and hybrid propulsion solutions to the ferry market.”
Data from the Maritime Battery Forum indicates that over 130 battery-powered ferries are already in operation around the world, and 90 more are on order. Within the last nine months, ABB has announced all-electric ferry projects with P&O Ferries, Washington State Ferries and the Busan Port Authority in South Korea.
“Operators serving inland waters have been among the pioneers of zero-emission propulsion, and ABB’s technology will support the sustainability goals of one of Europe’s great capitals,” said ABB’s Juha Koskela. “This project is a milestone for zero-emission propulsion, showing that proven technology is available today for sustainable fast passenger ferry transport.” | <urn:uuid:1a60e3f6-e808-432d-bcfd-bd9c824ec325> | CC-MAIN-2022-33 | https://chargedevs.com/newswire/abb-to-supply-electric-power-systems-for-ten-lisbon-ferries/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573540.20/warc/CC-MAIN-20220819005802-20220819035802-00473.warc.gz | en | 0.912926 | 511 | 1.664063 | 2 |
Nejapa de Madero (Municipality)
All the data of the municipality of Nejapa de Madero, with all the towns, from the smallest to the largest: El Camarón, Nejapa de Madero, or Las Ánimas.
Browse our list, and discover the photos, maps and statistics of these beautiful localities of the State of Oaxaca.
Nejapa de Madero is a Municipality of 7390 inhabitants, placed in the State of Oaxaca, with a fertility rate of 2.92 children per woman. 2.50% of the population migrated from outside the State of Oaxaca. 33.73% of the population is indigenous, 21.62% of the inhabitants speak one indigenous language, and 0.31% speak that indigenous language, but not Spanish.88.12% of the inhabitants of Nejapa de Madero are Catholic, 47.79% are economically active and, within this active population, 97.24% are employed. Additionally, 85.05% of the dwellings have piped water and 2.39% have Internet access.
Which are the villages with the highest number of inhabitants of the municipality of Nejapa de Madero?We have been analysing all the demographic data of Nejapa de Madero and in the following four towns live the largest number of people:
- El Camarón (2110 inhabitants)
- Nejapa de Madero (1914 inhabitants)
- Las Ánimas (606 inhabitants)
- San Isidro Chihuiro (468 inhabitants)
List with all the towns in the Municipality of Nejapa de Madero:
Arroyo de Lumbre (- inhabitants)
Arroyo Hormiga (115 inhabitants)
Carrizal (95 inhabitants)
Cerro Gallo (8 inhabitants)
Colonia Morelos (- inhabitants)
Corral de Piedra (159 inhabitants)
Cuajinicuil (3 inhabitants)
El Algodón (10 inhabitants)
El Camarón (2399)
El Camarón (-)
El Gramal (378)
El Limón (14)
Other towns, colonies, districts and neighborhoods in the Municipality of Nejapa de Madero: | <urn:uuid:6bc4346f-b5bb-4e7b-ba51-7b201d8edcc6> | CC-MAIN-2022-33 | https://en.mexico.pueblosamerica.com/oaxaca/nejapa-de-madero/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.861354 | 482 | 1.90625 | 2 |
Bottom Towed Fishing Gear Consultation - 2022
Southern IFCA is consulting on potential new closures for Bottom Towed Fishing Gear in the District.
Bottom towed fishing gears, or mobile demersal gears such as otter trawls or shellfish dredges, have been used by fishers for generations in the coastal waters of Dorset, Hampshire, and the Isle of Wight.
These techniques have the potential to impact or adversely affect sensitive seabed habitats in certain areas. Therefore, it is important to consider how management of these activities can be improved, to support a healthy marine environment and sustainable fisheries, promoting positive economic and social benefits for coastal communities. The 2022 Bottom Towed Fishing Gear Consultation, considers amendments to the Southern IFCA 2016 Bottom Towed Fishing Gear Byelaw based on updated evidence, including Conservation Advice provided by Natural England.
To achieve Southern IFCA’s duties, new management is necessary following the designation of additional MCZs in the District; and to ensure habitats and species in other MPAs are protected according to the most up to date evidence. This consultation also considers new management to protect well-understood sensitive habitats and species that are found outside of MPAs.
Please find the full consultation document here.
**UPDATE 08.07.2022: Please be advised, proposed closure areas mapped on nautical charts can now be viewed here. Please view alongside the full consultation document.**
This informal consultation closed on the 1st of August. A summary of responses will be available on the Southern IFCA website at the earliest possibility.
If you have any questions in the mean time, please do not hesitate to contact us:
by email at [email protected]
by phone on 01202 721 373. | <urn:uuid:51aa1d4e-f765-4b68-a0f6-41b3fbba0543> | CC-MAIN-2022-33 | https://www.southern-ifca.gov.uk/live-consultations | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.896786 | 373 | 1.570313 | 2 |
Bacillary layer detachment (BALAD) is a recently-described phenomenon characterized by the accumulation of fluid at the inner photoreceptor segment myoid level, proximal to the external limiting membrane (ELM). This finding has been found in patients with diverse primary diagnoses which share the common feature of serous exudation in the posterior pole. However, thus far there have been few reports in the literature of BALAD in patients with posterior scleritis (1-3).
Here we present a case of idiopathic unilateral posterior scleritis presenting with BALAD associated with rapid vision loss. The patient responded to high dose systemic steroids with near complete restoration of the retinal architecture and recovery of vision.
This case provides further evidence that posterior scleritis can be a cause of BALAD. The rapid presentation and excellent visual and anatomical outcome of this case is entirely consistent with known descriptions of BALAD in a variety of other conditions (3,4). In conjunction with other recent literature (4-6), this case supports the categorization of BALAD as an entity distinct from other forms of intraretinal fluid, retinal detachment, and retinoschisis. We present the following article in accordance with the CARE reporting checklist (available at https://aes.amegroups.com/article/view/10.21037/aes-21-61/rc).
All procedures performed in the study were in accordance with the ethical standards of the institutional and/or national research committee(s) and with the Helsinki Declaration (as revised in 2013). Informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the editorial office of this journal.
A 16-year-old male with no significant prior medical or ocular history presented to the emergency department complaining of right-sided eye pain, blurry vision, and ptosis. He had initially noticed vision changes and pain upon awakening the morning 5 days prior to presentation. He described his visual changes as a dark spot in his central vision that waxed and waned. He was ultimately brought to the emergency department after his father noticed a new right eyelid droop.
On initial exam, he was found to have a 1–2-mm right upper eyelid ptosis and decreased visual acuity to 20/70 in the right eye, with 20/20 vision in the left. On funduscopic exam, he had right optic nerve edema without hemorrhages or pallor as well as macular edema and dependent subretinal fluid (Figure 1A). The retinal periphery appeared normal. Funduscopic examination of the left eye was normal. He was admitted for further evaluation. Magnetic resonance imaging (MRI) of the brain and orbits did not reveal any tumors or brain lesions but was significant for a focal T1 enhancement of the right posterior globe (Figure 1B). Magnetic resonance arteriography/magnetic resonance venography (MRA/MRV) of the brain did not show any vascular abnormalities or lesions.
A B-scan ultrasound of the right eye showed choroidal thickening, subretinal and subtenon fluid, but no focal lesion or tumor (Figure 1C). Fluorescein angiogram showed optic nerve hyperfluorescence and punctate leakage throughout the macula without vasculitis, most consistent with a posterior scleritis (Figure 1D).
The patient noted sudden worsening of his vision symptoms his visual acuity was reduced to 20/400 in the right eye, along with a new right-sided relative afferent pupillary defect. Bedside optical coherence tomography (OCT) the following morning showed multifocal pigment epithelial detachments, edema of the retinal pigment epithelial layer (RPE) and hyperreflective curvilinear structures in the outer retina, reminiscent of outer retinal tubulation (ORT) surrounding dome-shaped hyperreflective material in the subretinal space (Figure 2A). Three days later the patient was seen in clinic. OCT showed progression of RPE and retinal detachments, with accumulation of dome-shaped layered hyperreflective material and punctate hyperreflective material in the subretinal space (Figure 2B).
Infectious workup, including rapid plasma reagin (RPR), tuberculosis testing, HIV testing, and serum antibody testing for Treponema, Bartonella, Rickettsia, Blastomyces, Histoplasma, Toxocara, Toxoplasma, varicella-zoster virus (VZV), Epstein-Barr virus (EBV), and Lyme disease were all negative. Herpes simplex virus (HSV) 1 IgG was positive, but serum HSV PCR was negative. Rheumatoid factor, anti-nuclear antibodies, anti-neutrophilic cytoplasmic antibodies, erythrocyte sedimentation rate, C-reactive protein levels and angiotensin converting enzyme levels were also all within normal limits.
The patient was treated with 500 mg intravenous methylprednisolone twice daily for 3 days followed by 80 mg (1 mg/kg) per day of oral prednisone for 1 week. His pain and ptosis resolved and by 1 week after initiation of steroids the RPE detachments had resolved and his subretinal fluid was reduced (Figure 2C). His prednisone dose was gradually tapered down to zero over the course of 2 months. He experienced no adverse or unanticipated events from treatment. By 5 weeks after his initial presentation, all intraretinal and subretinal fluid had resolved without the appearance of retinal exudates. He experienced a gradual improvement in his visual acuity to 20/20 over the course of 4 months. Repeat fundus exam at 4 months after his initial presentation showed only abnormal foveal retinal pigmentation, with subtle irregularity of the RPE and photoreceptor layers seen on OCT (Figure 2D).
In summary, we present a case of a child with acute posterior scleritis associated with the accumulation of fluid visible between the ELM and the ellipsoid band on OCT. This splitting, which likely occurs within the myoid level of the inner photoreceptor segments, is a finding that has been recently termed “bacillary layer detachment”, or “BALAD” (4-6). Previous studies have described BALADs extensively in patients with choroidal neovascularization, ocular toxoplasmosis, Vogt-Koyanagi-Harada (VKH) disease, exudative age-related macular degeneration, and acute posterior multifocal placoid pigment epitheliopathy (7-9). Ramtohul et al. (4) recently published an exhaustive literature review of case reports with OCT findings consistent with BALAD and found only three documented cases of BALAD associated with posterior scleritis (1-3). To our knowledge, the case report by Inan et al. (2) is the only previously documented case of BALAD in a pediatric patient with posterior scleritis. Our case expands the list of clinically documented bacillary detachments and adds to the body of evidence that posterior scleritis can result in this interesting finding.
Cicinelli et al. (3) hypothesized that in these cases acute fluid shifts in the posterior pole may force fluid into the neuroretina via hydrostatic pressure, causing a splitting within the photoreceptors due to shearing forces. Interestingly, posterior scleritis is commonly associated with scleral edema and specifically with fluid buildup within Tenon’s space. Our patient’s clinical course included an acute overnight worsening in his visual acuity several days following his initial symptoms. We hypothesize that this worsening may correspond to a rapid retinal fluid shift, consistent with the conclusions of Cicinelli et al. (3). In our patient, focal posterior scleritis lead to BALAD, however, the multiple case reports of BALAD associated with VKH reveal that a diffuse choroidopathy can also lead to focal BALAD.
Ramtohul et al. (4) postulate that accumulation of subretinal fibrin may disrupt adhesion between photoreceptors and RPE cells, increasing the likelihood of fluid entry into the myoid zone layer and therefore leading to BALAD under hydrostatic conditions that would otherwise lead to serous retinal detachment. Support for this argument notes that fluid within the BALAD cavity frequently includes suspended hyperreflective particles, not commonly found in subretinal fluid, likely representing inflammatory products, including fibrin, as well as photoreceptor debris. Our patient’s OCT (Figure 2B) also demonstrated accumulation of dome-shaped layered hyperreflective material and punctate hyperreflective material in the subretinal space, consistent with this hypothesis.
Previously published reports of BALAD also have noted that patients have generally had relatively rapid restoration of outer retinal architecture and were able to regain visual acuity following resorption of retinal fluid (3,4). This was also the case for our patient, who had significant improvement in his OCT and in his visual acuity at within a few months of steroid administration. We hypothesize that the retinal pigmentation observed on fundoscopy at his follow-up visit represents RPE hyperplasia resulting from his severe BALAD.
Despite the ubiquity of modern OCT imaging in retinal diagnosis, only recently has BALAD become a recognized manifestation of intraretinal and subretinal fluid. While there have been only a few case reports of BALAD associated with posterior scleritis, these cases have had many features in common with other documented cases of BALAD. This supports the hypothesis that, relative to other forms of retinal detachments and retinoschisis, BALAD has distinct etiology and prognosis. This interesting OCT finding undoubtedly merits more widespread recognition and further study.
Funding: This work was supported by an unrestricted grant to the Department of Ophthalmology and Visual Sciences from Research to Prevent Blindness.
Provenance and Peer Review: This article was commissioned by the Guest Editors (Ajay Singh and Jay M. Stewart) for the series “Medical and Surgical Challenges in Retina” published in Annals of Eye Science. The article has undergone external peer review.
Reporting Checklist: The authors have completed the CARE reporting checklist. Available at https://aes.amegroups.com/article/view/10.21037/aes-21-61/rc
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://aes.amegroups.com/article/view/10.21037/aes-21-61/coif). The series “Medical and Surgical Challenges in Retina” was commissioned by the editorial office without any funding or sponsorship. The authors have no other conflicts of interest to declare.
Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. All procedures performed in the study were in accordance with the ethical standards of the institutional and/or national research committee(s) and with the Helsinki Declaration (as revised in 2013). Informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the editorial office of this journal.
Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.
- Liu XY, Peng XY, Wang S, et al. Features of optical coherence tomography for the diagnosis of Vogt-Koyanagi-Harada disease. Retina 2016;36:2116-23. [Crossref] [PubMed]
- Inan S, Ertan E, Inan UU. Multimodal imaging in a child with severe posterior scleritis. Rom J Ophthalmol 2019;63:397-402. [Crossref] [PubMed]
- Cicinelli MV, Giuffré C, Marchese A, et al. The Bacillary Detachment in Posterior Segment Ocular Diseases. Ophthalmol Retina 2020;4:454-6. [Crossref] [PubMed]
- Ramtohul P, Engelbert M, Malclès A, et al. Bacillary layer detachment: multimodal imaging and histologic evidence of a novel optical coherence tomography terminology: literature review and proposed theory. Retina 2021;41:2193-207. [Crossref] [PubMed]
- Tekin K, Teke MY. Bacillary layer detachment: a novel optical coherence tomography finding as part of blunt eye trauma. Clin Exp Optom 2019;102:343-4. [Crossref] [PubMed]
- Mehta N, Chong J, Tsui E, et al. presumed foveal bacillary layer detachment in a patient with toxoplasmosis chorioretinitis and pachychoroid disease. Retin Cases Brief Rep 2021;15:391-8. [Crossref] [PubMed]
- Ishihara K, Hangai M, Kita M, et al. Acute Vogt-Koyanagi-Harada disease in enhanced spectral-domain optical coherence tomography. Ophthalmology 2009;116:1799-807. [Crossref] [PubMed]
- Liakopoulos S, Keane PA, Ristau T, et al. Atypical outer retinal fluid accumulation in choroidal neovascularization: a novel OCT finding. Ophthalmic Surg Lasers Imaging Retina 2013;44:S11-8. [Crossref] [PubMed]
- Ouyang Y, Pleyer U, Shao Q, et al. Evaluation of cystoid change phenotypes in ocular toxoplasmosis using optical coherence tomography. PLoS One 2014;9:e86626. [Crossref] [PubMed]
Cite this article as: Bligard GW, Lee AR, Hassman LM. Bacillary layer detachment presenting with posterior scleritis: case report. Ann Eye Sci 2022;7:29. | <urn:uuid:c61fc958-aedb-48ad-a393-7f4dcb9f2b7d> | CC-MAIN-2022-33 | https://aes.amegroups.com/article/view/6936/html | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.910341 | 3,088 | 1.726563 | 2 |
Paying it back: Millennials tackle caregiving duties for aging parents
As a caregiver to her mom with dementia, Carlsbad resident Julia Torres has had a unique experience compared with a lot of other people her age.
Nine years ago, when Torres was 26 and pregnant with her second child, her 55-year-old mother, Diana Gomez, was diagnosed with Alzheimer’s disease.
At the time, Torres, her husband and their daughter were living with Gomez; they continued to do so for a year, until Torres’ brother Alfonso Gomez could move in to care for her. The young family moved out but were able to live in their own place for only a year before Diana Gomez’s caregiving needs increased, and they needed to move back in.
While working part time as a waitress, Torres decided that if she was going to use work as her form of respite, she wanted to make that work meaningful — so she went back to school to earn a law degree.
“I remember leaving (the restaurant) and being like, ‘I’ll be back in like six months. I’m just going to try a semester out and see what happens,’ ” Torres said.
She succeeded in meeting her goal and is now an attorney for the U.S. Department of Justice at the immigration court in Otay Mesa. And her mother, now 64 and with advanced dementia, is receiving hospice care in an assisted living facility a mile from Torres, who is pregnant with her third child.
While Torres’ experience is unique, she is not alone in her journey as a millennial caregiver.
According to a survey from AARP earlier this year, 23 percent of those caregiving for adults are from the millennial generation. The survey found that millennial caregivers are typically caring for a parent or grandparent with a long-term physical condition in a “moderate- to high-intensity care situation” for an average of 25 hours a week.
“In talking to some of those millennial caregivers, what we’re finding is their struggle — some of them still having to go to work and having to help in a way that they haven’t been able to help before,” said Martha Rañón, executive vice president for Southern Caregiver Resource Center, or SCRC. The nonprofit organization, based in Kearny Mesa, offers classes, support groups, short-term counseling and respite care for caregivers across San Diego County.
For some, the 20s to late 30s age range can be the prime of their life. Those in the millennial demographic — defined as those born between 1981 and 1996, according to the Pew Research Center — can be settling or settled into a career, developing long-term relationships, becoming new homeowners or saving money for a house, and oftentimes are in the process of becoming parents to children of their own.
But for some millennials, the unpaid work they provide as caregivers to parents, grandparents, partners or other loved ones can disrupt the process of fulfilling their other ambitions.
“What we’re actually seeing is that those goals are kind of being put on` hold or modified, because the care that is needed for these individuals is greater than is expected,” Rañón said. “We know several caregivers who have had to really juggle between working and their personal life and also caring for their loved ones.”
Although caregiving can be a difficult task to take on in general, doing so during the COVID-19 pandemic and stay-at-home orders has added even more stress to the lives of caregivers, especially millennials like Torres, who are helping their children with distance learning while caring for elderly parents, Rañón said.
Through respite with the help of groups such as SCRC, caregivers are able to do self-care or complete errands while knowing their loved ones are safe.
“Those who are also in that sandwich generation or those who are millennials who are maybe going to school and also have Grandma and Grandpa at home — or maybe it’s their parents that they’re caring for — it’s really challenging because they’re at home,” Rañón said.
Caregiving from a distance
Around the time San Diego resident Matthew Zuraw’s father John retired four years ago, his mother Nancy started noticing differences in his dad’s behavior and personality. When John was diagnosed with Alzheimer’s disease a year later, Zuraw and his siblings banded together to split caregiving duties in support of their dad, now 68, and mom, 64.
To build a new lifestyle where he could work remotely as needed to care for his parents, Zuraw quit his job with Geico. He now works for himself as the owner of several businesses, including Better Brains, which sells RememBar snacks made with ingredients to promote healthy brain activity, like almonds, cherries and blueberries.
In his free time, he volunteers as the event chair for the annual Longest Day fundraiser with the Alzheimer’s Association San Diego chapter.
Zuraw’s new professional status allowed him the freedom to travel back to Virginia earlier this year to help his parents transition from the home they had lived in for three decades into a retirement and continuing care community. While he stayed with his parents for more than a month, his wife was at home in San Diego.
Although caring for them from afar has impacted many aspects of his life, he’s happy to do it, to repay his parents for raising him.
“I think there’s definitely a strong role reversal that’s happening now,” Zuraw said. “When I go to visit, I cook my parents’ meals, I make my dad meals, I helped do their laundry, I helped do their grocery shopping.
“As a kid, your parents do all that kind of stuff for you, and now I’m getting the opportunity to do that back to them, which I view as a really big responsibility and also a blessing at the same time, in that I have an opportunity to kind of pay that back to them.”
Support from nonprofits
Whether it’s through health condition-specific nonprofits such as Alzheimer’s San Diego and the Alzheimer’s Association, or through broader organizations like the Southern Caregiver Resource Center, millennials like Zuraw and Torres can benefit and thrive as caregivers with additional community support.
Torres acknowledges that her relationship with her husband suffered somewhat because of the intensity and stress in caring for and living with her mother before the transition into assisted living.
“I think we were really on the brink of reassessing our life and figuring out if we could do it, at the point when we found a home for my mom,” she said. “That kind of gave us exactly what we needed to repair our relationship, because it had gone so much downhill, since I didn’t learn that balance for a long time.”
She has since received resources from Alzheimer’s San Diego, and she recommends reaching out early in the journey as a caregiver to get help before reaching a point of high stress.
“I think I waited too long also to reach out for help with Alzheimer’s San Diego — I didn’t learn about that until much later on. I was just trying to do all this on my own,” Torres said. “I wish I would’ve learned about all those resources earlier on or at least accepted them.”
Aside from the support Zuraw gets from the Alzheimer’s Association, what has helped him as a caregiver, he said, is finding a sense of balance through co-caregiving with his siblings, playing with his cat, and exercising.
“I think my relationship with my siblings helps in kind of leaning on them for additional support,” Zuraw said. “I have a great wife, which is very helpful. And this year, I’ve just started getting back into more physical exercise and started running again.”
While he has an optimistic outlook on life, he worries that his future children may miss out on having a meaningful relationship with their grandfather.
“It’s just unfortunate to think about, there might be a chance my dad never knows my kids, and that’s pretty tough,” he said. “Whether that’s that we don’t have kids before something happens to my dad or he’s at a place where he can never learn their name or never appreciate them. That’s definitely something on my mind.”
No matter what, Zuraw said he’s learned so much from his dad over the years that his memory will live on through him.
“I think my parents have taught me a lot of lessons, that even if my dad doesn’t explicitly know my kids, I think that he will definitely be a part of their lives in some form or fashion,” he said.
Despite the pandemic, SCRC continues to provide respite care to local families, as well as virtual resources to continue its support of the caregiving community. For more information about its programming, visit caregivercenter.org/ or call (858) 268-4432. To find other caregiving resources throughout the region, visit sandiegouniontribune.com/caregiversd-map.
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You may occasionally receive promotional content from the San Diego Union-Tribune. | <urn:uuid:570b02b9-c171-45c7-be21-1c7346c5beca> | CC-MAIN-2022-33 | https://www.sandiegouniontribune.com/caregiver/news-for-caregivers/story/2020-09-15/millennials-tackle-caregiving-duties-for-aging-parents | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573540.20/warc/CC-MAIN-20220819005802-20220819035802-00473.warc.gz | en | 0.979919 | 2,029 | 1.617188 | 2 |
Bruxism is a medical term that describes the act of grinding the teeth and clenching the jaw. Sometimes, people grind their teeth without it causing any symptoms or problems. However, regular and persistent teeth grinding can cause pain and discomfort in your jaw and it can wear down your teeth. Teeth grinding can also cause headaches and earache. Most cases of teeth grinding (nearly 80%) occur subconsciously during sleep. It is usually associated with contributing factors, such as stress or anxiety (see below). Bruxism also affects people when they are awake, although this is more likely to be clenching the teeth and jaw, rather than grinding. Most people do it subconsciously while they are concentrating. What causes bruxism? Bruxism almost always occurs in association with other factors. About 70% of bruxism cases that occur during sleep are thought be related to stress and anxiety. There is also a strong association between bruxism and obstructive sleep apnoea (OSA). OSA is a sleep disorder where your breathing is interrupted during your sleep. Teeth grinding can also be caused by taking certain antidepressants. Your lifestyle can also have an effect. For example, regularly drinking alcohol, smoking and using recreational drugs, such as ecstasy and cocaine, increase your risk of bruxism. Doctors sometimes refer to teeth grinding that is caused by an underlying condition as “primary bruxism” and teeth grinding associated with a medication, condition or your lifestyle as “secondary bruxism”. Treating bruxism There are a number of possible treatments for teeth grinding but only a few have been shown to be effective. Behavioural therapies and the use of mouth guards, mouth splints and mandibular advancement devices (MADs) are recommended treatments for bruxism. Other treatments, such as muscle-relaxation exercises and sleep hygiene, may also help manage your symptoms. If you grind your teeth while you are asleep, you may need to wear a mouth guard, mouth splint or a MAD at night to protect your teeth from further damage.
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For more information on Bruxism feel free to contact the practice or ask your dentist at your next check up. Talk to a dentist
Grinding the teeth can cause wear. The canines and the front incisors wear first. The enamel can be lost exposing the soft dentine underneath.
When teeth are ground from side to side particularly during sleep this can wear down the front teeth and the molar cusps can be chipped and damaged. Clenching also tenses the jaw muscles and creates impact within the skull. This may cause pain and headaches. An Occlusal Splint can be used to protect the teeth and prevent contact. | <urn:uuid:88dee865-8577-40b6-a26b-c3aff4267a7c> | CC-MAIN-2022-33 | https://kincorthdental.co.uk/treatments/teeth-grinding/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00673.warc.gz | en | 0.955636 | 583 | 3.390625 | 3 |
How many syllables are in penalty? 3 syllables
Divide penalty into syllables: pe-nal-ty
How to pronounce penalty:
US English Accent and Pronunciation:
British English Accent and Pronunciation:
Definition of: Penalty (New window will open)
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Penalty Poems: (See poems with this word. New window will open)
Synonyms and Words Related to Penalty
penalisation (5 Syllables), penalization (5 Syllables), punishment (3 Syllables)
agio (3 syllables), executing (4 syllables), execution (4 syllables), penalisation (5 syllables), penalization (5 syllables), penology (4 syllables), punishment (3 syllables),
Three syllable words that rhyme with Penalty
What do you think of our answer to how many syllables are in penalty? Are the syllable count, pronunciation, words that rhyme, and syllable divisions for penalty correct? There are numerous syllabic anomalies found within the U.S. English language. Can penalty be pronounced differently? Did we divide the syllables correctly? Do regional variations in the pronunciation of penalty effect the syllable count? Has language changed? Provide your comments or thoughts on the syllable count for penalty below.
Comment on the syllables in Penalty
A comprehensive resource for finding syllables in penalty, how many syllables are in penalty, words that rhyme with penalty, how to divide penalty into syllables, how to pronounce penalty in US and British English, how to break penalty into syllables. | <urn:uuid:c9f9d4e6-50f9-4940-8030-a48073ff2aee> | CC-MAIN-2022-33 | https://www.syllablecount.com/syllables/penalty | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573540.20/warc/CC-MAIN-20220819005802-20220819035802-00473.warc.gz | en | 0.862361 | 372 | 2.53125 | 3 |
WHAT ARE THE MAIN CONTRIBUTING SECTORS OF SRI LANKA’S ECONOMY?
According to the World Bank, Sri Lanka is a developing country with an increasing annual economic rate as a result showing great potential for future economic growth. While the country as a whole has historically been slow to adapt to changes, it has experienced significant changes in its economic structure within the past 10 years, especially since the end of its civil war back in 2009. The country has traditionally relied on the plantation industry as a major source of economic output, however, nowadays other sectors have overtaken this top spot.
The Services Sector
Contributing to more than 60 percent of Sri Lanka’s GDP as of 2016, the services sector is by far the largest generating source of the country’s production. According to the Central Bank of Sri Lanka, the wholesale and retail trade took the largest slice of the services sector, with more than 20 percent of all Services sector’s contributions coming through this trade.
Nevertheless, coming at second place was the Transport and Communication segment, which combined contributed to more than 14 percent of the outcome of the Services industry.
At third place was the country’s fast growing tourism industry, which accounted for roughly around 10 percent of the service industry’s total outcome.
Finally, the banking sector, insurance as well as real estate were at a respectable fourth place and contributed roughly 9 percent to the service industry’s output.
The Industrial Sector
Contributing to more than 30 percent of Sri Lanka’s entire economic output was the industrial sector, which has seen some surprising growth for the past five years.
As stated by the Central Bank of Sri Lanka, the largest proportion of the industrial sector was comprised of manufacturing businesses, which accounted for more than 17 percent of the segment’s entire output.
Apart from that, the construction industry also had a notable footprint in the industrial sector, with roughly 10 percent of the segment’s revenue funneling through the growth of the construction industry. The plethora of possibilities born in the construction sector post war, have led to some of the most significant developments over the past few years.
Other segments of the industrial sector such as mining or electricity had only a minor impact contributing roughly 3 percent and 2.5 percent, respectively.
The Agricultural Sector
Agriculture has always been one of the main Sri Lanka’s economy’s contributors due to being the main livelihood of the majority of the population (2.6 million of the labour force of the country). However, the agricultural sector was the least contributing subdivision of the Sri Lankan economy, with less than 8.5 percent contribution as of 2017. This sector was also the only major segment that saw a gradual decline of its total share of contribution (showing a -2.5% contraction) for the past 10 years.
The Fisheries industry was the largest contributor to this segment with more than 1.4 percent of its total output. The tea exports were at second place at one percent, while rice cultivation was at third with a 0.8 percent contribution.
Even though agriculture used to be the dominant contributor to Sri Lanka’s economy, by now it is evident that the country’s output is more driven by the service sector. This sector should be further advanced due to increasing internet penetration (32%) as well as the on-going investments towards infrastructure such as the Colombo Port City and Western Region Megapolis. The latter also means that there will be more output through the industrial sector itself. Additionally, Sri Lanka, particularly Colombo, is offering highly skilled and educated specialists (especially in IT sector); often at a comparatively better rate than other surrounding countries. This leads to MNCs to look to expand their operations to the country and their FDI flows should further support country’s economic growth and strengthen the services sector. Such foreign company development would also mean growing demand for office (which is already high) and residential spaces, which in turn would lead to the growth of the industrial sector. | <urn:uuid:d558096b-2790-4fad-bd5d-16b3315c92b4> | CC-MAIN-2022-33 | https://lmd.lk/what-are-the-main-contributing-sectors-of-sri-lankas-economy/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882572161.46/warc/CC-MAIN-20220815054743-20220815084743-00473.warc.gz | en | 0.967021 | 836 | 2.984375 | 3 |
Want more proof that social media are great reporting tools? Look no farther than “Keys to the Castle” an investigative story Jace Larson reported for KUSA in Denver that picked up a 2011 duPont-Columbia Award. The story uncovered a housing scam that victimized people facing foreclosure as well as people looking to rent.
As the award citation noted, “The team talked to dozens of victims, used local, state and federal public records, court records, surveillance and social networking to uncover the plot.” But just how did social networking come into play?
After hearing from two people who said they’d been tricked by someone named Greg Castle, Larson began looking for him. Turned out the man’s real name was Gordon Miller and guess what? He had a Facebook page.
“You can see people’s friends, if they’re not hidden,” Larson said. “Half of his friends were from Malaysia.” The background in Miller’s profile photo seemed to suggest that he was in Southeast Asia, and Malaysia made sense, because it has no extradition treaty with the United States.
“We developed a lot of information about him that helped with our sources,” Larson said. That information came in handy when Larson caught up with Miller’s parents, who confirmed where their son was living. “It arms you with so much more. All the little pieces come together to give you a better idea of who you’re going to talk to.”
Larson also sent messages to Miller’s friends, using his station Facebook account. If they responded, he told them what he was working on. Several people told him via Facebook that Miller had been in trouble before.
Journalists under-use Facebook, Larson says. “People are willing to talk. It’s like knocking on a neighbor’s door. They will tell you a lot.”
This video from the duPont ceremony includes part of Larson’s story. Definitely worth watching. | <urn:uuid:954c0fe9-f924-4f59-a678-6fa8afc46063> | CC-MAIN-2022-33 | https://newslab.org/using-facebook-for-a-tv-investigation/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882572304.13/warc/CC-MAIN-20220816120802-20220816150802-00473.warc.gz | en | 0.980278 | 426 | 1.648438 | 2 |
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