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Nortriptyline & escitalopram combo
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Any experience on it,
Regards
| 1 |
Is someone taking rexulti for anxiety as well as depression?
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I take effexor 187.5mg for anxiety and it is not working very well. I have GAD,MDD and possible bpd or bp2. My doctor is added 1,5mg of rexulti to help the effexor. I don't know if rexulti helps anxiety and what dose is for anxiety since I still have a little relief. I've heard higher doses are more sedating and lower doses are activating. Is that true?
| 3 |
What to try next??
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What to try next
Ive been on Viibryd 60mg since 2019 and always took other medicine with it.
Fast forward to a few months ago in 2022 (context: starting seeing some relief of depressive symptoms since i started nasal ketamine and finally was able to only be on viibryd 60mg and vyvanse)
Generic comes out I switch to it, and it doesn’t work as well. After trying it for a bit and starting to see decline in my progress, tried to switch back to brand name only and saw improvements again.
Present: new insurance company won’t cover name brand and can’t afford to pay $300+ every month to stay on it.
I had to go cold turkey because of insurance coverage problems and delay in PA etc.
I speak with my doctor in a few days and I’m hoping we can figure out a new game plan.
Wanted to know if anyone has been in a similar situation where they were on it for years and either switched to something else or similarly went cold turkey and started a new regime.
I’ve basically tried over 15+ medicines and think I’ve exhausted the SSRIs SNRIs. Here’s everything I’ve tried:
- Celexa
- Viibryd
- Rexhulti
- Abilify
- Olazapine
- Latuda
- Lamictal
- Venlafaxine
- pristiq
- Zoloft
- Wellbutrin
- mirtazapine
- doxpin
- Trazadone
- clonazapam
- Xanax
- Lithium
- Lexapro
- Remeron
- Modafinil
- Gabapentin
I’m hoping maybe a newer medicine that I haven’t tried would be suggest next by doctor but wanted to know what other routes people have taken before
| 6 |
Mood stabilizers for diagnosed anxiety - looking for experiences
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Cross-posting due to the urgency of things, I hope it's alright.
I am diagnosed with mixed anxiety & depressive disorder + ADHD.
I've tried different meds before:
paroxetine 20 mg - when I was on it I thought it was somewhat ok, but the night sweats would wake me up at least once a night + I got almost lethargic & it was really difficult to wake up + I had "blank states" and after coming off it I am not comfortable with experiencing it again. Withdrawals were unpleasant, mainly brain zaps.
duloxetine 30 mg - worked fine at first, sweated less to not at all, unfortunately stopped working in a couple of month; raising it to 60 mg killed my sleep + returned sweats and I generally felt unwell. Withdrawals were awful, much worse than with paroxetine, and took about a month to subside.
bupropion 150 mg xl - what I am on right now. Took me 3 month to get used to it, helps my energy but doesn't help my anxiety/maybe even makes it stronger.
So I need to add something to the mix. I got escitalopram, but even 2.5 mg has me shaking & crying constantly and I doubt I can get through. I have considered mood stabilizers before and am considering switching now.
**What I am worried about with them:**
\- Long-term heavy side effects (akathisia, etc)
\- Even worse withdrawals
\- Insomnia / weight gain / night sweats side effects (basically the same stuff that made me switch from some other meds spare for weight gain)
\- Experiencing emotional blunting
I would love to hear any experiences with mood stabilizers. I am mostly looking into lamotrigine and aripiprazole; lithium is likely off the table for me because getting regular blood tests is a pain in my country and I can't guarantee that I would be able to get them.
| 5 |
How would you compare fluoxetine to sertraline?
| null | 5 |
help with mental fatigue?
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Hello! I've been dealing with burnout, depression and maybe some type of PTSD. Main symptom right now is mental fatigue. I can actually do sports and dont exhaust but right now on most days I feel tired in my head almost all day. I wake up feeling tired in the head. Are there any supplements that helped you with this type of fatigue (might as well call it a lack of mental energy or emotional exhaustion) or any exercises that you can recommend?
| 10 |
I think Mitazapine increased my anxiety.
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Hi there everyone I'm just wondering if anyone else has had this side effect with taking Mirtazapine. When I was on 15mg I didnt feel as anxious, but since starting a 30mg dosage(2 months ago), I've been feeling way more anxious. Has anyone else dealt with or dealing with this issue?
I'm honestly feeling anxious as hell and even more depressed, I'm already suffering from physical symptoms of anxiety(internal tremors, had them before last year(they went away after 6 weeks) & depression, I overdosed, then rushed to hospital & so on).
I've been told by three doctors & a psychologist that my physical symptoms are because of anxiety, yet I keep drifting to worse things(doctor google, I know I should go down that rabbit hole. I keep doing it like an idiot and it makes me more anxious)... just feel like giving up honestly, can't deal with any more issues.
| 4 |
Lyrica is the only med that helps me
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My grandma got prescriped lyrica for nerve pain, i been taking zoloft 50 and wellbutrin xl 150mg for a long time now, i got a very slight improvement in suicidal thoughts and energy, but i still feel very very apathetic and strong avolition it making my life unwhorty and still jobless, plus i have depersonalization and derealization along with mood swings (hell).
Btw some days ago i was having a derealization episode, i was anxious to even think, so i decided to take lyrica as i heard i calms anxiety, i took only 75mg and after 2 hours i switched my mind into positive, i was happy, i wanted to clean my room, i wanted to be social, i felt like i healed my chronic depression, i even gave my resume to mc donald's wich i procrastinated since october... Well the next day after i took it i have fallen again into a deep melancholic depression, i felt worthless, i regret everything i did the day before, it's like i switched back into my old personality, even worse than before, got suicidal again and felt depersonalization so hard, i'm, tempted to take it again but i don't want to f\*ck it up even more since i don't have a prescription.
Now it's possible that lyrica can really be the right med for me, or it was just euphoria? I am scared i ruined my brain now, current meds are not working anymore, i feel so so down.
Anyone have similar experiences? I don't know what to do to get out of this nightmare, i'm really tired, nothing works, therapy helped me but still i'm feeling a burden i can't function and i can't keep like this.
| 9 |
Depression drug blood test for recomendations taken in Jan. I have questions?
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I took a blood test in Jan to see if pristiq 100 mg daily is good for me than other drugs. I am having trouble reading the results. Cytochrome P450 2D6/2C19...???? is this it?
| 1 |
NSI or TAK-653 or Tianeptine
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Hello everyone, so I have about $60 left after purchasing my RGPU-95 & PPAP. I'm trying to decide what I can get that will possibly help me with my depression. The Adderall is helping me with the ADHD and the depression too honestly but there are days when I wanna take three or four of my pills instead of the two I'm allotted for the day. This is partly why I bought these two chemicals. To try to save my prescription from running out before it's refill day. I'm not doing this often, I usually have enough till about 2-4 days before I meet with my psyche doctor.
I need someone to really drive the point home for the TAK-653 being helpful for depression. I've seen life changing results here and I've also seen people buy it and say "it didn't do anything" or "it did something, then it did nothing".
I really want to purchase NSI-189 and try that instead but I also want to take into account the TAK-653 might really be worth it.
tl;dr Convince me to buy either TAK-653 or NSI-189 for helping me with my depression.
vvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvv
I posted the above to /r/Nootopics to try get help but I might as well post it here. I suffer from depression and I'm looking into novel ways to treat it. If you know what any of the 3 are or have experience I'd like to hear your opinion and advice. I have like 10g of Tianeptine coming from China as free samples. I literally contacted every Tianeptine vendor and asked for a sample with a python script I wrote and I got like 6 or 7 to send free samples. I'm being sent that and some other goodies.
I have been on SSRIs, SNRIs, benzodiazepines and I'm currently on Suboxone 2mg twice a day for opioid maintence. I'm a recovering heroin addict with over 250 days sober. I live day in day out feeling very empty, just not feeling anything at all which I think is Anhedonia.
Any advice welcomed.
| 2 |
What should be the next step
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I have just been started on venlafaxine. I am cautious to even start due to horrendous brain fog and fatigue from the last antidepressant I was on.
I have been on:
\- agomelatine
\-desvenlafaxine
\-bupropion
\-lithium
\-sertraline
\-duloxetine
\-valdoxan
\-mirtazapine
\-mianserin
\-vortioxetine
\-moclobemide
Also had TMS, and been on quetiapine, olanzapine, pericyzine, diazepam, zopiclone, temazepam and had different therapies over the years.
Just tapered off moclobemide but still taking quetiapine to sleep.
Psychiatrist wants me to start venlafaxine. Im thinking what's the point - I hate the side effects and it never seems to do anything for my depression.
I have seen posts about ECT and different therapies with ketamine or other drugs? How do people go about these things? My psychiatrist will not offer it.
| 10 |
Any experience with brexpiprazole?
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Just got prescribed as an augment to my venlafaxine and mirtazapine for depression/anxiety, I’ve tried regular Abilify but how does this stack up?
| 1 |
starting ketamine troches today. I hope they help.
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My depression has gotten really bad. I want to do tms but can't afford it. I am praying this helps me.
| 10 |
What to do if I find SSRIs too stimulating?
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I have been on fluoxetine for about 15 days now and I am feeling very simulated this evening. Finding it hard to relax and calm down.
I am thinking about getting off it to feel more grounded again. I am not sure how healthy would it be to get off it this way.
What else can be done to feel more grounded?
I am only taking 20 mg.
| 8 |
What has helped you with regret?
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I’ve had some sort of dysthymia with occasional major depressive episodes for well over a decade now, though the last five or so months in particular has been constant self-loathing on an almost-daily basis. I do think I’m capable of getting better (or, better enough) but now at the age of 30 the prospect of doing so feels both hopeless and pointless, being that I’ve wasted so much of my life thus far and squandered so many opportunities, for not knowing better when I very well was capable. I know in the grand scheme of things 30 is still young, but I just can’t seem to let go of the self-directed anger; in a way it feels like my biggest barrier. Like even if I somehow attain better protective factors in place, more structure, less SI, etc. I won’t be able to fully commit to life with all this past baggage weighing me down. So, what’s helped you the most? A particular model of therapy? A specific medication? Psychedelics? TMS, ECT? Spirituality, religious transcendence?
| 29 |
Has anyone looked at claiming psychiatric malpractice for being kept on a medication that gave them disabling brain fog, or even was just plain ineffective?
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So this is a rabbit hole I keep finding myself in, and I need to resolve it one way or another. I'm curious if other folks here have found themselves considering or pursing a malpractice case when their doc didn't recognize that their meds were causing problems, or even just failed to change meds that were ineffective?
BTW, I'm hoping this is appropriate for this sub. It's very much about my path with with my depression meds.
The backstory: I was on Effexor for years, during which I was in a fog and I. just. could. not. do. any. thing. I couldn't even work. I switched to Wellbutrin a few months ago, and wow, I'm functioning and putting my shattered life back together. This story gets deeper, though I'm not sure if it is fully relevant to malpractice. For a little while, I was attributing my improvement just to Wellbutrin working better for me. I briefly added Lexapro to my regimen and suddenly. I. could. not. do. any. thing. again. This fog cleared up as soon as I stopped taking the Lexapro. So now I'm thinking that not only was Effexor ineffective, it, like Lexapro, may have been causing a lot of my problems.
I can't stop wondering if being kept on Effexor for so long, with no attempt to try something else, rises to the level of psychiatric malpractice. Here's why I think it may, even though there is a substantial amount of speculation here:
* I'd think there's a certain point where changing a medication regime is standard practice when nothing else is working. During 3 years with this psychiatrist, I tried so many things. Immediately quit smoking weed. Therapy twice a week. Group sessions. Exercised. Meditated. Sat under a SAD lamp. Added additional medications. And so many more things. Now, years later, I find that just switching medications would have done the trick. Fuck.
* The brain-fog I was having is a known possible side effect of Effexor. I'd think that my psychiatrist should have been aware of that and screened for it, particularly after so many interventions didn't work. I also have a suspicion that the regular surveys I took for them didn't exactly line up with depression. I know at several points I said that I didn't have that sense of heaviness in my chest, but that I was just more of a dead blank with no energy or focus or sense of time.
* The HMO I was with had understaffed mental health services, and my psychiatrist may have been under pressure not to try medication changes because they require more frequent appointments. (BTW, the therapist I saw frequently was outside that system.)
* After 3 years, my psychiatrist dumped me as a patient because they believed they couldn't help me - despite no medication changes. This was pretty devastating and I just gave up trying to find help for a couple of years, other than getting refills from my primary care doc.
* Finally, there there was grievous harm done to me. I burned through my retirement savings, ran up crippling debt, have a huge gap in what was a really good career, and spent a long time thinking I was an utter piece of shit because I couldn't snap out of the situation.
On the other hand, there are things that may mean there was no malpractice:
* I did go back to smoking weed after quitting for a year had no effect. (Having quit is well documented because of drug test results.) This is one of the things my psychiatrist cited when they dumped me, and I think they attributed the brain fog symptoms to this rather than my meds.
* This psychiatrist wasn't the one who started me on Effexor. I had moved from out of state, where it was initially prescribed after I tried a number of other medications. That psychiatrist is less on my radar because they weren't part of an overburdened system, and they didn't dump me. But I do wonder a bit if I have a case against them.
* It's been a couple of years since I've seen this psychiatrist. But as I mentioned above, they dumped me, leading me to give up on seeking help, and I've been depending on my primary care doc for prescription refills. The switch to Wellbutrin was kind of an accident because I was quitting smoking, and my doctor recommended it because it is known to help with that.
Then there are several practical thoughts:
* Psychiatric malpractice seems far more difficult to define and prove than something like a botched surgery. Even if I'm right about all the failures, it could still be difficult to make the case. But I think that the understaffed department and getting dumped by my psychiatrist do make for compelling context.
* I'm also not sure if it would be possible to really prove that Effexor was giving me a debilitating brain fog. I'm not entirely certain of it myself. But, I think this is a secondary argument because Effexor was not working for whatever reason.
* Maybe I just have some strong motivated reasoning going on here. I find the thought of malpractice comforting because it means that I'm not a total piece of shit for not being able to take care of myself for so long. On top of that, money from a settlement could get me out of the crippling debt I developed and maybe restore some of my retirement savings. Hell, maybe I could even get into a financial situation where I could afford to start a family, because right now, I'm old enough that I would have to choose between supporting kid and rebuilding those retirement savings.
So has anyone else investigated or followed though with charging their doc with psychiatric malpractice for not recognizing that a med was causing severe problems, ore even just not doing the work to get you on the right med? I'd love to get some perspective and advice. I need to either get the ball rolling, or let this go.
Thanks!
TL;DR: I'm wondering if I have a psychiatric malpractice case. My prior m-doc of many years never tried changing my meds even though nothing was working. I've recently made a med change, am able to hold down a job again, and asking myself why the fuck this wasn't done years ago.
| 10 |
If TMS fails is that it?
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I've been getting it for about 3 weeks now 4 days a week and it's kind of just doing nothing. This was kind of my last resort
| 13 |
Is muscle weakness from Ability transitory?
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Hi, has anybody gotten muscle weakness from low dose ability and has it subsided with time?
| 1 |
What if ECT and IV ketamine make the depression worse?
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TL;DR Looking for input about what to try after bilateral ECT and IV ketamine made my depression worse.
I’ve been trying to find a solid treatment for my depression and anxiety (MDD and GAD are my main official diagnoses) for almost 10 years now. I’m 45/female, and I’ve been through all the usual talk therapies and drugs (22 total, including SSRIs, SNRIs, NDRI, TCAs, SGAs, lithium, MAOIs, etc., some multiple times and many in different combinations), in addition to mushrooms and psychiatric procedures (TMS x2, unilateral and bilateral ECT, and IV ketamine) — all without sustained improvement.
My post here is about my reaction to ECT and ketamine, though. I had a strong negative reaction to those two treatments in particular; specifically, my depression got substantially *worse* immediately after the treatment. I’m wondering if anyone else has had this reaction and/or has any thoughts about what it might mean. I talk to my procedural psychiatry doc tomorrow and I’m afraid the next suggestion will be vagus nerve stimulation — if so many other treatments haven’t worked, I have serious doubts about VNS when a) most results take a long time to appear and b) studies haven’t shown a high degree of effectiveness in general. I’m hoping maybe someone here has some ideas specifically based on the fact that IV ketamine and bilat ECT made my symptoms worse. Thanks in advance.
| 8 |
I think my SSRI is making me feel increasingly worse
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I have severe, persistent OCD and depression and in July I started taking 100 mg of fluvoxamine (luvox). On luvox, I feel like I have a bit more brain activity, like I can be a little bit more active, and like I feel emotions a little bit more, but my life is still unbearable, and I'd actually say it's more unbearable than ever. It's like ever since I've taken it my life and my thoughts have become increasingly more excruciating, my fatigue is much, much worse, and I've felt increasingly close to acting on suicidal thoughts. My brain is really messed up, but sometimes I think about how I felt before it and how it made me feel a tiny bit more like myself and it makes me not want to quit it. I know I should talk to my psychiatrist about this, but should I decrease my medication, so maybe I can keep some of the benefits but help the bad effects? Or should I ask to try a different form of antidepressant and avoid SSRIs?
| 11 |
Study: Brain Serotonin Release Is Reduced In Patients With Depression
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This study used a new and more direct method to measure serotonin in the living human brain, and the results suggest reduced serotonin (release) functioning in depression...Participants with depression and healthy controls underwent PET scanning with to measure 5-HT2A receptor availability in the frontal cortex; the two groups did not differ significantly at baseline. In a second scanning session three hours after drug administration, healthy control participants had significantly reduced 5-HT2A receptor availability, indicating an increase in serotonin levels. Participants with depression, however, did not show a significant decrease in binding potential, suggesting they had a blunted serotonin release capacity in key brain regions.
https://neurosciencenews.com/serotonin-depression-22089/
| 33 |
I am impressed with Selegilline.
|
After so many years of hearing about but not really knowing what it was or where to even get if, I added low dose Selegilline to my regimen.
There is absolutely no question that in day 4 I am significantly more focused and energized, There’s a slight edginess that concerns me, but it’s kind of good. I can’t just sit around doing nothing…which is mostly what I do in life.
I’m doing 2.5mg sublingual 2x a day, but I may reduce that to 1.25mg.
Just wanted to throw this out there for those with intense apathy and lack of drive. This absolutely helps and helps quickly. It’s so hard to find anything that just gives you a little more dopamine! It makes all the difference.
Anyway, something to consider. One of the first “nootropics/supplements” to really make a notable difference. And I’ve truly tried well over 100 of them. I hope it keeps doing its thing! ☀️
| 11 |
Purchase NSI-189 in US
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Thinking about giving this a go and looking for a good place to buy in the US. Thanks
| 2 |
Does anyone else get completely stuck/paralyzed?
|
I find myself getting so stuck that I can’t even do anything like running errands or chores. I’ll start to get ready for the day by putting on make up but then I get stuck and can’t get dressed and leave the house.
It’s really frustrating and I can’t seem to push myself to do things that I need to do. I know there’s the advice to just take the next step, but I find that once I reach a certain point, I just can’t move forward.
I think right now in particular, I’m just very overwhelmed with stressors like moving out of state and rather than do you things I need to do for this move, I’m just completely stuck.
| 88 |
Does anyone else feel LESS depressed during a cold/flu?? Or just me??
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I actually look forward to having a cold bc I get to feel better. Like my moderate-severe depression becomes mild if not barely that. I actually feel happy and uplifted and my body doesn’t feel weighed down only by cold symptoms. It’s really odd and I can’t really pinpoint why this is. It isn’t because I get to rest, as most days I’m as bedridden when not sick with a cold as the time that I am- nothing changes about my life. I had covid recently and it’s the first time I’ve experienced an uplift in mood and feeling an array of emotions in a long time, and my SI and overthinking goes out the window which is nice.
Edit: oh also I had not been medicating, I avoid cold medicines unless it’s really needed
| 31 |
Lexapro is working and it feels so great
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Hey everyone, just wanted to share my experience with lexapro and thank this community for helping me with my troubles over the past few months.
The Lexapro is finally working after almost 2 months and I'm experiencing no side effects.
I've made a lot of lifestyle changes as well such as fixing my sleep schedule and cleaning up my living space. They sound like small things but have made me feel so much better.
I can finally start getting my life back together. No persistent alcohol or drug abuse over the past 3 or 4 months as well.
That's all I wanted to share thanks for reading!
| 25 |
Your Clomipramine experiences
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I’m currently on 75 mg of Clomipramine for social anxiety,OCD,depression, intrusive unwanted thoughts and panic attacks and have been at that dose for almost two weeks now. I feel side effects kick in at just such as shakey hands and a buzz feeling in my head, like a weird caffeine rush.
I'm wondering how long does it take for the medicine to work because I feel like everything is getting worse ?
Also I'd be happy if you share your experiences with me.
Thank you !
| 2 |
Discord Server
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Hey everyone I noticed a lot of us feel alone and empty so I made a server a community server for people that don’t really have anyone to talk too so you don’t feel the ways you feel. We all deserve love this server has a place for everything you may be interested in talking with other people about and you can always express yourself if you choose or just lurk and see what other people going through. Send me a message if you are interested I love you all.
| 5 |
Natural supplements anyone?
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Has anyone first tried natural supplements and can recommend some before medication? I know st, johns wort was one. Seeing if anyone was able to lift their depression .. I also have anxiety but this subreddit is for depression so … thank you!
| 0 |
Time course of sertraline? And a serotonin theory of depression
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Can someone explain why people on sertraline (despite having a 24-hour half-life and only taking a week to reach steady state concentration) are told to wait 6-8 weeks for the effects to be noticed?
On a related note, I've been trying to understand the serotonin theory for depression better. Is it more accurate to say the problem is not a lack of serotonin, but a lack of neurogenesis that fails to take place due to the lack of serotonin?
| 1 |
Taking Wellbutrin at night for better energy in the morning?
|
Does anyone else take their wellbutrin before bed instead of the morning?
I’ve been doing this lately because I feel like the wellbutrin kicks in 8-12 hours after I take it, so by the time I wake up it’s kicked in.
Anyone else?
Edit to say: I take 150 xr
| 23 |
Has anyone found relief from Ketamine?
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Share your experience in the comments
[View Poll](https://www.reddit.com/poll/11his12)
| 5 |
I’m about to stop taking all my meds
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I’ve been on so many this last year. Like, so many. They all make me feel worse. I wait for weeks and weeks for side effects to go away only to find I still don’t feel better. At my wits end. Currently weaning off Effexor, ramping back on Zoloft. Also on buspar max dose, abilify, seroquel low dose, klonopin as needed. Klonopin is the only one that works but I rarely take it since it’s addictive.
I don’t know where to go from here.
| 1 |
New to group
|
Hi all- been lurking for a while. I’m avoiding any SSRIs as I’m sensitive to pharmaceuticals- and until I tried the supplement route first.
I’ve been doing
Sam-e 400mg - first thing in morning
2 omegas - 300mg each - with breakfast
St. John’s wort- 300mg - once a day with a meal.
Chelated, magnesium - 200 mg at night.
I’ve been on this for a week and feel out of the mud but not yet at baseline.
Any tips or advice? I read lots of conflicting information on Saint johns wort interactions with everything but idk if it’s doing anything with the Sam-e
| 4 |
Accuracy of GeneSight testing?
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I just received my results from GeneSight, and the only antidepressant I have no interaction with is Pristiq. Every other antidepressant was either a moderate or significant interaction. I was wondering if anyone has any insight as to how accurate and trustworthy this test is? My previous psychiatrist thought the test was a waste, but my current psychiatrist is the one who ordered the test. It seems like it’s quite controversial. However, I have noticed that the people who don’t think the test is accurate have no explanation as to why. For example, my previous psychiatrist would not order the test, but he would not tell me why he wouldn’t. Does anyone have any factual-based opinion on the test? If you think it is inaccurate, could you give some evidence as to why? I’m just trying to figure out how much I should rely on the results. Thanks!
| 25 |
Eutropoflavin
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Has anyone tried this? It works?
| 3 |
I had one day where my autism completely vanished. Help me get to the bottom of how and why, and how this could be recreated?
|
Hello there. I have autism/aspegers. I don't believe I would have been rated as having that at birth and in my early years, and it seemed to develop overtime? Mild in teenage years, moderate since adulthood.
On halloween night, I experienced a number of hours where I was no longer autistic. I know that sounds weird to say, but it was true. As in if a researcher would have found me that day at that time, I would not have met the criteria for it, or even closer.
**Context leading up to this moment**
I was on Nardil (an MAOI) at the time, and had recently raised my dose enough for the "honeymoon" phase of it, which puts many people in some degree of hypomania for a bit. Was on around 40 mg at this time.
This aspect of nardil had given me really bad insomnia, so I had just started trazodone, something like 50 mg, the night prior.
I had likely been sleep deprived to some degree even with the trazodone. Sleep deprivation gives me at least some amount of social benefits.
Then, I had a flashback of some health anxiety that was almost giving me a panic attack, so I took probably .5 mg lorazepam. This was a few hours before night came.
Nothing else at the time was any different
**What I mean by didn't rate as autistic**
Halloween night was just a coincidence, I didnt dress up, didn't have any expectations. I went to a bar with a girl I had been seeing. Her and I had been there a couple times prior.
The last time I was there, I was so wigged out by the loud music and all the people. It was extreme enough that after we went to her place, I was completely depleted, and needed to not communicate for a while, take a nap, then I was okay, and we finished our night. So that's me in a normal state. When I simply walked from our table to the bathroom, my brain hyperfixated on every person I came across in a very hypervigilant kind of a way. It makes them feel weird and I'm trying to just focus my attention forward, but it's almost impossible. I'm generally so overwhelmed that I almost walk into people. So just walking to a bathroom is a very stressful experience. Alcohol does not help this.
On halloween night everything was different. Obviously I had these substances in my body, but I did not feel high at all. For example, I bet if I shot up some heroin, I'd feel pretty good in any situation I was put in. But I didn't feel good, I felt normal. I hung at the bar with my lady. The music didn't bother me, or all the people. I was friendly to our waitress and even made jokes. And then here was the biggest (anti) mindfuck. I walked to the bathroom and it was just... normal. My brain didn't need to scan every person I walked past. Again I wasn't like so high that my brain just ignored it. I was instead just processing information normally, like how normal people do.
**Trying to draw conclusions from this**
While I found Nardil to be helpful, basically all modern manufacturers make a shitty version of it that does not absorb correctly in the body. It's really a fucking shame. (If I was David Foster Wallace's estate, I'd sue the hell out of Pfizer for a wrongful death, and I bet I'd win. Research that if you're curious.)
So anyways, Nardil while in theory could be a game changer, I don't think I can tolerate more than small doses of it. It gave me 3 months of severe, life destroying insomnia. Trazodone maybe gave me a somewhat similar anti anxiety effect once or twice the day after consumption, but it wasn't repeatable.
And Lorazepam, I take .5 mg about 4 days a week. Recently I've been replacing most of those with passion flower. Lorazepam/passionflower help me be able to not get overly stressed out at my job and burn out. While helpful, they are far from any cure or perfect situation.
_______________________________________________
So what do you think could have contributed to my complete remission of autism symptoms? Is there any way I can reproduce that sustainably for the long term future?
Right now I'm looking into memantine, clonidine, agmatine, and going back on nardil but at a sub-insomnia dose
| 5 |
Depression Linked to Immune Response in Some People - Neuroscience News
| null | 14 |
Anyone been "cured" yet?
|
I was wondering has anyone been "cured" of depression. What's it like? How long did it take?
| 6 |
Should i change psychiatrist?
|
I am of course only looking for opinions
Dx: treatment resistant depression, major depression or wtv its called
Current meds (for the last two months) seroxat and xanax, dropped concerta bc i cant find it (took it a month and a half)
Ive been with my current psych for a year now, hes very very busy, appointments are always a month away even if he tries to make them two weeks away lol
Ive been on ongoing treatment for 8 years, and during my time with this doctor (during a bad episode) ive taken about 8 dif meds on different combos, currently my main complaint is suicidal thoughts and extreme fatigue. My next appointment is in two weeks, and takes ages to answer my messages. Hes nice, i like him, takes his time ans asks me questions about my life, used to see him in person, but on december i moved and had to see him online, and i dont feel the same care and attention from him.
My psychologist, whom i like a lot too (also now online only) recommends me to change doctors, bc she dont quite agree with his treatments.
So now im considering it, i dont wanna do it bc it would be like starting all over again and i dont wanna... im tired... but also maybe i do need in person attention?
My question is, what would you do? Start again and hope for the best? Or push through with the same guy and hope for the best? Lol
Ty for anyone who may read or comment. I love this community.
| 9 |
Provigil VS Vyvanse
|
Hey so I have a prescription for Vyvanse, it helps to keep me awake and to focus (I have Narcolepsy and ADD). But I can't fall asleep when I'm on it even like 16 hrs later, especially if I have even a single cup of coffee 1st thing in the morning directly after having my Vyvanse. And anyway so I switched back to using my old provigil prescription, which was also given to me for the same reasons (I wanted to try something new!) And my question is I have a HUGE career defining exam coming up in just 3 days. I have been consistently taking Provigil, for the last 3 months to help me study for it. I was wondering if on my exam day, should I switch back and take a Vyvanse (One off?) Or should I stick to Provigil? I'm worried about tolerance (I take 1 day a week off from Provigil).
| 1 |
Abilify is making me so tired and I'm sick of it.
|
Ever since I started taking it I've been so exhausted throughout the day and it's making me depressed that I can't practice drawing or coding or anything.
My Psychiatrist said to move around more and go out and take half but that made me just as tired. I took half of half and I felt like I haven't slept in 2 days even though I napped three times in one day.
I'll be switching back to Seroquel and WON'T be touching Abilify again.
| 11 |
Anyone on Clomipramine? (Anafranil)
|
I’ve found Clomipramine so far to be the most effective out of all the meds I’ve tried. I’ve tried Lexapro, Zoloft and Fluvoxamine/Buspar, in the past with limited success. Zoloft also gave me bad side effects like bad sleep and stomach issues. I’m on 200mg of Clomipramine right now and it’s helping with my OCD and depression but not too much so I’m gonna be increasing the dose to 250mg for a week and then 300mg. I get no side effects from this medication either and it helps a lot with my sleep. What are y’all’s experiences?
| 2 |
Sertraline tapered or switch to fluoxetine first?
|
I've been taking 25mg of sertraline for 6 months but I'm still afraid to stop completely after two bad experiences a few years ago... Better to go down to 12.5mg, or use the drop version, or switch to fluoxetine 20mg for a month and then suspend maybe after doing for two weeks one day on and one day off, given that fluoxetine has a very long half-life compared to other SSRIs (2 weeks vs 24 hours)?
| 1 |
Experiences with Lamictal for ADHD/Depression?
|
For those with ADHD and depression, what are your experiences with Lamictal?
I'm currently on 60 mgs of Strattera to treat my ADHD. It's been super helpful in helping me focus and calming down all the noise that goes inside of my brain.
I've noticed my anxiety was a little heightened while on it, but right after the year mark of taking it, I feel like I'm in a depressive episode. Executive dysfunction is at an all-time high and I have a general apathy for most things.
I struggled with ADHD, panic disorder, and major depressive disorder in college and was medicated to the point where I wasn't a human. I'm terrified of taking anything to help with the anxiety or depression because I'm afraid of going totally numb again.
Today, my psych said this would be a good alternative to traditional depression medication. For those who have both ADHD and depression, how did it work for you? Did you go/feel numb at any point?
We're starting off on 25 mgs a day for two weeks, eventually getting up to 100 to see how that goes.
Thank you in advance for your help and sharing your experiences.
I don't want to feel like this anymore, but I really don't want to lose my ability to feel anything at all.
| 9 |
Trying to find a med that works, at what point do you move on to the next one?
|
Hey all,
Was on Celexa for 15 years and it stopped working. Moved to Nefazadone 6 weeks ago and am just now hitting the therapeutic dose. Not feeling great and have some side effects, night sweats and weak/jelly legs.
At what point do you abandon a drug you are trying and move on. Moving from Celexa to Nefazodone sucked. Not looking forward to another move.
Any advice is greatly appreciated.
| 4 |
I wish there was medication that actually made you happier instead of doing the extra work yourself to be happier when its difficult with life’s stressors
|
Cause believe me this has been a win and lose battle pretty much my whole life so far
| 33 |
Pristiq, anhedonia, help :(.
|
I went to my psychiatrist earlier this week and told her about my anhedonia. I’ve been struggling with panic disorder and mdd for 3 months now. Anhedonia came on soon after. I ended up in the hospital. Felt better off and on and then about two weeks ago full blown anhedonia. Since then I’ve been reading a lot about it. Some ppl say SSRI’s/SNRI’s worsen it and cause permanent lasting effects. When I saw my psychiatrist I told her about the anhedonia and how I was scared to take SSRI’s/SNRI’s/AP’s, and how I would prefer an MAOI and she basically just told me that my anhedonia is a result of my MDD and put me on pristiq. But I’m worried it might be the result of Viibryd, because I was put on it a week or so before I went to the hospital, the day I went to the hospital I stopped feeling most things. So I’m confused as to where it comes from, if it’s stress, or SSRI induced. Anyways I took my first pill of pristiq today about 2-3hrs ago. I feel nothing but anxious and a worsened headache. Someone please tell me it’ll get better :( I’m so scared of medication now and continuing the medication. Life does not feel worth living with anhedonia. It has already taken so much from me. Has anyone here had any relief from anhedonia with SSRI’s/SNRI’s. I’m so scared. I don’t know what to trust anymore and I’m feeling so hopeless
| 1 |
What depression/anxiety medication are you on that makes you carry little to no dread throughout your day and actually look forward to the day with hope no matter your responsibilities?
|
This is definitely a struggle lately since I’ve been out of work
| 20 |
Overactive K opioid receptors
|
I strongly suspect that among the causes of my depression there is an overexpression of these receptors, that they are present in an exaggerated number compared to the families of opioid receptors that give positive emotions, I had read that an antidepressant that goes to antagonize them is currently in investigation, otherwise I can think of tianeptine which could compensate for this by being an agonist of the MOR group which is instead associated with euphoria, the DOR group also seems to be associated with positive emotions, I was wondering if there was something legal or in grey area that worked on these things in addition to mitragynine (kratom) which I already use.
I just checked and the NOR receptors are also associated with depression and unlike the KORs which give sedation they also give anxiety.
| 6 |
Energy-positive antidepressants besides Wellbutrin / buproprion?
|
Bupropion/Wellbutrin is famous for being good for energy but it's the only drug that I've been unable to tolerate so far (anger, irritability, anxiety -- oddly all far worse than ADHD stimulants, which I've also tried at the higher doses).
The energy side effect was useful, however, so I reckon that if I can find a "cleaner" or less anxiety-and crankiness-producing form of stimulation that I may be onto something.
I've heard some good things about:
* Prozac among the SSRIs
* The SNRIs in general - although the potential for horrible withdrawals has scared me away from them so far
* Trintellix (which is what I've just started) and the new serotonin modulators (because of their affinity for serotonin receptors like HT1A which, I've read, can stimulate a bit of norepinephrine/dopamine production)
Is there anything else which is known to be good for depression and also on the better side for energy, motivation, drive?
| 19 |
10 days on 20mg fluoxetine
|
Few of the changes that I observed were
* Found to be better at mental arithmetic
* Found to be better at speaking second language. Thinking in second language.
* Increased yawning throughout the afternoon.
* Reduced intrusive thoughts
* Reduced rumination
* Increased hand tremors
* Increase in a different kind of anxiety.
* Better memory because of reduced intrusive thoughts
* Reduced self consciousness and social anxiety.
* More assertive
* Improved focus
| 2 |
For those who have tried both abilify and rexulti, was one more effective than the other?
| null | 8 |
Olanzapine dosage for depression
|
Hi, if anyone here is taking olanzapine for depression, what is your dosage? My psych wants to up my dosage to 7.5 mg, is that even still effective for depression?
| 2 |
Starting Rexulti
|
Hopefully someone out there can help me make sense of the beginning of taking Rexulti.
Pretext: I’m currently on 100mg of Zoloft.
Today was the first day of taking Rexulti. I’m adding it on to hopefully clear up lingering depression and anxiety. Anyways I would just describe it as feeling weird. Not bad or good just kinda activated but nothing to over the top. Just a really weird feeling. I know with each person is different but wanted to see if anyone else had the same thing? Thanks in advance.
| 11 |
Can tryptophan alleviate SSRI withdrawal?
|
Can tryptophan supplementation decrease problems following discontinuation of an SSRI? I have twice tried to stop taking them and twice after 1 or 2 months I start having relapses.
| 2 |
Fasting and Monster Energy Zero
|
Fasting and Monster Energy Zero kills my depression sometimes. Sometimes only fasting, sometimes only Monster Energy (usually Zero as sugar sometimes makes me mentally unstable, or even anxious, or angry or paranoid; only sometimes!)
Different energy drinks work sometimes as well, and can replace Monster Energy when it stops working. But I won't recommend an energy drink every single day. That won't work either, for me at least, and it's not good for your health. Coffee sometimes works, but it's not good to drink that every single last day either.
You can switch energy drinks out for energy or focused centred powders, but it's the same with them.
Some days eating only a certain meat for the first hours of the day works. This is called carb cycling, it means you take a break from carbs.
I've been depression free for weeks by following a ketogenic diet, but I've only been able to do such things a few times. That's why I have to rely on a Glycemic index and/or blood sugar diet instead, and carb cycling helps with that, and energy drinks and powders and related stuff helps me as well. I can go from feeling really bad to feeling great through any of these methods, but none of them seem to work all the time. Just my experience, take it as you will but no hate pls.
# Monster Ultra White Zero Energy Drink, e.g., ingredients:
Carbonated Water, Citric Acid, Erythritol, Taurine, Sodium Citrate, Natural & Artificial Flavors, Panax Ginseng Extract, L-Carnitine L-Tartrate, Sucralose, Caffeine, Sorbic Acid (Preservative), Benzoic Acid (Preservative), Niacinamide (Vit. B3), Acesulfame Potassium, D-Calcium Pantothenate (Vit. B5), Salt, Guarana Extract, D-Glucuronolactone, Inositol, Pyridoxine Hydrochloride (Vit. B6), Cyanocobalamin (Vit. B12). Monster Energy Blend: Taurine, Panax Ginseng Extract, L-Carnitine, Caffeine, Guarana Extract, Glucuronolactone, Inositol.
| 5 |
Effexor XR and SI- increase or switch?
|
20F. MDD and ADHD, with dysautonomia and a few other diagnoses.
I started on Lexapro in Sept. 2021 and stayed on it until December 2022. Titrated up to 25mg after it wasn't helping much, so psychiatrist switched me to 37.5mg venlafaxine and then up to 75mg. Not having any improvement, and I've noticed pretty significant increase in my anxiety and suicidal ideation. I'm also having more symptoms of dysautonomia (less tolerance for exertion, more fatigue, etc.) but I'm also stressed out so all of the worsening symptoms I'm seeing *could* be from that.
Psychiatrist has been out of the office for like two weeks and I haven't seen her for three. Should I try increasing my dose or consider trying something else?
| 1 |
Vyvanse
|
Does Vyvanse alone work for anybody else? I've been looking through the sub and only see negative reviews about it.
I find that taking 20mg on “bad” days and 10mg on “good” days works really well for me.
I've never been diagnosed with BED/ADHD/ADD, I'm also interested to hear if anyone else has been offered Vyvanse instead of the traditional antidepressants.
| 18 |
Clomipramine dose
|
Hiya
Im in a bit of a bad place with my meds. I was on clomipramine 150mg and was doing ok but i was absolutely piling on the weight and i didnt like it. So i was then put on milnacipran which gave me shockingly high blood pressure so now im off that, currently not taking anything and im thinking of going back on the clomipramine.
Im just wondering if anyone else of on this and what dose are you taking?
Thanks!
| 2 |
Compatible Anxiety Meds with Tinnitus
|
Hi all,
Tinnitus sufferer and currently on nortriptyline 75 mgs that helps to carry on it.
For anxiety I tried pregabalin and lexapro that worsened my tinnitus.
Benzos are difficult to be prescribed.
Any suggestion is welcome
| 2 |
Low Dose (25mg) of Trazodone and Effect on Serotonin
|
Hi, I take the lowest dose possible of Trazodone (25mg) every evening for sleep since about 8 months now. I started to take them because I got bad insomnia from long covid (triggered fight or flight mode all the time and constant awakening) and it helps in that regard. I do however think that recently I got a little bit of emotional blunting and a kind of forced energy from it also I think my adhd got worse. I tried to stop it a few months ago but I got bad depression and brain fog so I resumed it. I'm not really sure if it is the trazodone or longcovid because I also still have symptoms from long covid like PEM for example.
Seems a little strange since it is such a low dose but I do know that most (all) SSRI (or similar) have a logarithmic effect between dose and Serotonin reuptake inhibition so even low dose can have a moderate / high effect on Serotonin reuptake right?
I'm not sure if it is worth it going through withdrawal because they do help for sleep but I don't like the effects which may or may not come from them.
| 2 |
Dark Sides of Depression: Awareness
| null | 5 |
Best medication for anhedonia/numbness?
|
Have been succesfully treated for major depression with lexapro and rtms. All that’s left is anhedonia and feeling kinda numb/indifferent. Quitting lexapro has been a disaster so have to be careful with that but is there an antidepressant I can safely change to or augment with?
I tried buproprion (didn’t work) zoloft (worked well) and paxil (weight gain/fatigue).
| 21 |
question about private psychiatry, prescription management, and benzo prescribing in UK
|
sorry if this is the wrong sub idk where else to post this question
im currently taking clomipramine 10mg. just got OKd to up to 20mg at the 8 week mark. i know this is painfully slow titration but this is typical for NHS.
im thinking of seeing a psychiatrist privately in part due to the speed of titration, and because this med (despite working a little for depression) is not providing any relief for social anxiety so I'm seeking an adjunct in (i hope) the form of say a benzo.
i know benzos are addictive, etc. but this is around 10th psychiatric med I've tried to no effect (for SA). I've been suffering with SA for all my adult life and i want to put an end to it. not interested in rotating another dozen psych meds for the next 5 years only to find myself in the same place.
is a psychiatrist able/likely to take over management of the clomipramine and titrate at a higher speed? I'm not sure about the prescribing process through private clinic.
second, how likely is it that a private psych would agree to a daily benzo as an adjunct to the antidepressant? i know it's impossible on NHS but is it commonplace enough in private psychiatry to have some hope?
asking because i don't want to waste money on several consultations to be told i should take another SSRI. the one time i visited a psych privately before, that is unfortunately what happened.
thanks :3
| 2 |
Has Anyone Tried The Anxiolytic Etifoxine?
|
What are the effects like? Did you notice a profound anxiolytic effect? I would love to hear some experience reports?
| 9 |
Can Olanzapine stop anxiety attacks?
|
Anxiety attacks have been becoming more common for me, my last one was last week and it felt horrible like I was dying.
I've been on lexapro 20mg for about a month and a half now and I'm waiting for it to work.
I'm very worried about having another anxiety attack as they're really scary and it could be pretty embarrassing if it happens in public.
I don't want to be prescribed any benzos as I'm worried about developing an addiction to them so I was wondering about using Olanzapine 5mg instead.
Would the Olanzapine help if I feel one coming on?
TL;DR: Is Olanzapine effective in stopping anxiety attacks
| 4 |
Inpatient treatment
|
Those who have checked themselves into inpatient care - what was the final straw? How did you make the decision? Was your stay helpful?
| 17 |
Mood enhancement from physical exhaustion
|
I tend to have anhedonic depression, mostly without anxiety.
I noticed that my mood gets a lot better (less rumination, more stimulated to do stuff, more pleasure in doing activities) if I'm sleep deprived and if I fast and walk a lot to the point of getting lightheaded.
I know there have been studies on the effect on sleep deprivation on depression, and for the fasting and walking I think it's the body releasing a bunch of adrenaline and endorphins to put up with the effort...for this last one the effect is so strong that it feels almost like a high.
I was just curious if there's anyone else that gets this.
| 5 |
Starting an atypical regimen today: Stablon & Auvelity
|
I’m really excited to give this a shot. I’m burned out with the SS/SNRI train and it’s time for something new.
Both of these antidepressants should also kick in much faster. I will keep you updated on my progress!
| 13 |
Effexor vs Cymbalta
|
Which is better for anxiety , Effexor or Cymbalta?
| 3 |
Any subreddit for discussing depression meds in the drug development pipeline?
|
There's a subreddit called Research Chemicals I see but this looks like something very different.
I'd be interested in learning more about the drug development pipeline for depression medications.
What's currently making its way through trials? What's showing promise? What's looking like it could be approved soon? What's failed?
Any community where this might be a common topic of discussion?
| 6 |
Is cross tapering supposed to feel this awful?
|
I've been on Luvox for 7 years and about a month ago started a cross taper to Prozac. I feel fucking awful. I told my psychiatrist everything is worse - my anxiety is unbearable, my depression is worse, I can't eat, I'm nauseous, etc. - and she told me it wasn't related. Then she prescribed me gabapentin to try to help and I just feel tired AND awful now.
Is this going to get better? Like once I'm fully on Prozac should this get better? I'm in the middle of it now so I feel like I cant stop, but im not getting much reassurance anywhere that these symptoms will get better when I'm done.
| 2 |
rexulti effective dose
|
I heard That Rexulti effective dose for depression Anhedonia and demotivation is 2 mg per day , Right now I am on 1 mg for 1 week Should i increase the dose after talking with my dr or 1 mg is suffiecient ??!
| 1 |
Drugs to feel emotions while stopping obsessive thoughts
|
I'm currently dealing with total emotional numbness and anhedonia but at the same time I'm struggling with unwanted intrusive and obsessive thoughts. I don't even feel anxious anymore, just exhausted by constantly having to fight them.
My entire personality is gone, zero interest in life and living on autopilot. I feel indifferent towards pretty much everything.
Anyone who got treatment for something similar?
What meds do you think are best suitable for my case?
I'm going to see my gp soon for this, just curious to read responses.
| 16 |
EXtreme high blood pressure with Milnacipran (SNRI)
|
Hi
Im having a terrible time with crazy high blood pressure which my psych attributes to Milnacipran an SNRI. My last readings were 178/108, 157/98, 154/103. I am not overweight. Im a bike courrier and cycle 3/400km a month. I am insanely careful about my diet. Dont drink of smoke (am a heavy vaper though) so it is absolutely not the usual culprits for hypertension.
Im a bit concerned my psych has just said well stop the milnacipran and see if the hypertension improves, which means for the first time in years i wont be on any antidepressants and im worried about that.
So really im just asking about ADs and hypertension in general, anyone have any experience with this?
Ta 🙏
| 1 |
Has anyone tried Thesis Nootropics?
| null | 3 |
Most Comprehensive Depression Regimen, mood, cognition, focus, motivation, sex drive, fitness, longevity
|
**Moclobemide** 600 mg
The most researched RIMA antidepressant, serotonergic with no sexual side effects
**Modafinil** 25 mg IN TID
Tested antidepressant adjuvant, selectively activates cerebral alpha1 adrenergic receptors, inhibits DAT and upregulates VMAT2, CBF enhancer
**Bromantane** 25 mg IN TID
Neurasthenia medicine, TH and GDNF upregulator, HDAC inhibitor
**Tianeptine** 12.5 mg TID
Tested antidepressant adjuvant, selective mu opioid agonist, vesicular release protein upregulator
**Agomelatine** 1 mg SubL
Tested antidepressant adjuvant, melatonin receptor agonist, 5HT2C antagonist, upregulates KMO in the brain and modulates other branches of the tryptophan metabolism
**Metformin** 500 mg
Metabolic regulator, AANAT upregulator, neurogenesis inducer
**Insulin** 10 IU IN TID
Metabolic regulator, neurogenesis inducer
**SR9009** 15 mg IN TID
mitochondrial enhancer, reverb agonist
**7,8 DHF** 20 mg IN
selective TrkB agonist
**ACP105** 5 mg
AR partial agonist
**Memantine** 1 mg
Tested nootropic, NMDA modulator, selective extracellular NMDA selective antagonist, glutamate release inhibitor, nicotinic receptor antagonist, chronically upregulator, neuroinflammation regulator
**Rapamycin** 5 mg once weekly
Antiaging compound preventing excess proliferation
Plant derived and endogenous compounds:
**Ascorbyl Palmitate** 500 mg
**Curcumin** complex 500 mg
**Alpha Lipoic Acid** 500 mg
**Pterostilbene** 250 mg
**Taxifolin** 250 mg
**NMN** 250 mg
**Dihydroberberine** 150 mg
**Ginkgo extract** 120 mg
**Cinnamaldehyde** 100 mg
**Vanilin** 100 mg
**Theaflavin** complex 100 mg
**Ubiquinol** 100 mg
**Zinc Picolinate** 80 mg
**PQQ** 20 mg
Quality **B complex** moderate doses
Amino acids:
**Citruline** 6 g
**Creatine** 5 g
**Histidine** 4 g
**Glycine** 4 g
**Magnesium L- Threonate** 2 g
**L- Tyrosine** 1 g
**L- Theanine** 1 g
**D- Serine** 250 g
**D- Aspartate** 250 g
Lifestyle interventions:
**Dry Sauna** 15 mins daily
metabolic regulator, heat protein activator, CBF enhancer
**Cold Immersion** 2 mins daily
cold protein activator, catecholamine release regulator
**Infrared Sauna** 15 mins daily
Mitochondrial enhancer and metabolic regulator
**Electroacupuncture** DU-20 x ST-36, 12 V, 15 mins
neuroinflammation regulator, tryptophan metabolism regulator
**Transcranial Magnetic Stimulation**, 15 mins
catecholamine release enhancer, prefrontal cortex activator
Lots of exercise mostly **bike cycling** but also **weight lifting** and **calisthenics**.
**Plant based diet** with the **fasting mimicking protocol** every 6 mo.
Remain lean and build body mass and endurance gradually.
**Psychedelics** every 6 months.
**No Caffeine, Alcohol, Recreational Drugs, Ejaculation.**
What would you change here? Spot any interactions? Any additions?
| 5 |
First-time taking antidepressants and have been prescribed venlafaxine (Effexor)
|
I, 22f with ADHD, MDD, and SAD have just been prescribed venlafaxine XL at 37.5 mg/day. It will be my first time taking antidepressants and I am worried about the possible side effects and withdrawal syndrome on this medication. Is there anything else I should know before starting this type of medication? Any success stories?
I appreciate any help you can provide! Thank you!
EDIT: Thank you so much for all of your answers!!! You have helped me a lot!!
| 4 |
Impact of Medications on your relationships with other people
|
What have you observed?
I am taking SSRI (fluoxetine) again and I have observed an increase in the feeling of Self importance. I want more attention and better treatment from people and feel upset when I don't get it.
I also feel an increase in impulsiveness, as in not waiting for others to complete and speaking mid way.
What meds helped you have most satisfying relationships?
| 9 |
If Wellbutrin didn’t help with your depression, did you switch over to anything else that did?
| null | 6 |
SSRIs don't work for me, what can I add on to my Wellbutrin?
|
Hello, first time posting here. Wellbutrin xl did good for me in pulling me out of bed and get somewhat back to life. I am still having anxiety however and I literally hate SSRIs and had bad experiences every time, namely weight gain and emotional blunting.
I want to add on something that will help my anxiety and won't trigger weight gain since I am insulin resistant already in the first place. I am stumped and have no idea on how to proceed. Any ideas?
| 13 |
Antidepressants don't work.
|
Hi. I have been depressed for many years and i've searched for a cure forever. I have tried all kinds of medication, antidepressants, antipsychotics. Most of it made me feel worse and didn't work, however opioids i noticed were the only thing that made me feel better and i don't even take them for depression. My biochemistry is totally weird.
My question - Is there anything out there that could work?
| 5 |
What other drugs are there like vortioxetine / Trintellix?
|
I was reading earlier about Trintellix's interesting mechanisms of action (serotonin reuptake inhibition plus agonism at 5HT1A resulting in a bit of effects on norepinephrine and dopamine.... as well as agonism of a few more serotonin receptors... collectively classed among the serotonin modulators).
What other drugs are out there that are seretogenic from few different angles (and which combine serotonin reuptake inhibition with agonism of 5HT1A with its potential to reduce sexual side effects)?
| 3 |
bupropion for sex drive in males
|
I am a 45 year old male suffering from anxiety and insomnia. My libido is non existent for some time now and I'm turning into an asexual being if not already one. I've been self medicating after quitting the quietapine my psych prescribed cause after a year and a half i noticed it elevated my glucose levels. I ve been on 30 mg of mirtazapine for about a month and it helps me sleep through the night.i was thinking of adding 150 mg of bupropion to the mix just to check if i can get my sex drive back. Any thoughts?
| 3 |
What medication took away the pain for you?
|
The worst part about my depression is the pain. It’s like a physical feeling in my chest combined with sadness that makes life hell. Has anyone found a medication that helps with this?
| 13 |
How long does Lexapro/ssris stay in your system after discontinuing?
|
How long does Lexapro stay in your system after discontinuing and how long do withdrawal symptoms last? I stopped taking it about four days ago and I have been feeling really out of it and irritated the depersonalization, emotional numbness/ blunting ,fatigue and sexual side affects all feel worse now than when I was on the medication and I've been really stressed out about it and that I might have pssd or something even though I know its unlikely.
I was on it for two months at five mg, I am also worried because I did'nt taper because I am already on the lowest dose.
Thoughts? How long should I expect this to clear up?
| 2 |
Do you have to wean/taper off fluvoxamine & seroquel? I’ve only been on them for about a month and got prescribed them in the hospital.
| null | 3 |
Effect of ADs on heart rate? RHR dropped 10 points on lexapro, kind of concerned.
|
Started lexapro last week and my heart rate has absolutely plummeted, and I’m kind of concerned. I have pots so it’s normally pretty high but it’s now resting in the 50s vs 70s usually.
| 1 |
Heart pain
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Hey everyone, I been experiencing heart pain from time to time or sudden dizziness when I walk sit etc. I went to a cardiologist last year and they said even my heart hormones are fine, that I have nothing. Im hitting the gym frequently and I never have problems when I work out, hike, or run. My blood test results are always normal but why is this heart pain not going anyway ? I have depression since last year and im on mirtazapine now. I was taking 30 mg but my doc lowered the dose back to 15 and im doing fine with it. Can anyone give an idea ? Because this is freaking me out and affecting my mentality. Im at work now and I can not stop thinking about it + I feel it. ( im turning 23 this year and im 4th year college student) can please someone give me any ideas ?
| 3 |
Reduced feeling of affection towards friends
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I have been taking fluoxetine for about five days now and I realize that people don't make me feel as happy as they used to. I used to feel very happy when I got a chance to help them.
I feel a lot different now. I am more upfront and blunt. I have upset few people.
But I am feeling a lot better on this medicine, except the hurting people part.
| 1 |
Body spasms
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My muscles are contorting and twitching, Is this normal?
| 3 |
It has been almost 3 years at the time of sharing this here. I still have near-constant sensitivity issues on the left side of my face and other parts of my body, as well as memory issues and emotional blunting. Does this sound like a bad reaction to reinstating, or something else like COVID, etc?
| null | 2 |
Afraid of using benzos too much
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Trying so many meds for my anxiety depression and ocd but nothing is working. I only get brief relief from benzos but I try to not take them everyday because I’m afraid of getting addicted and building a tolerance. So everyday I have to decide do I want to feel miserable or risk another time taking a benzo.
Effexor is making me so much worse. Also on abilify. Have been on lots of others. Talking to my psychiatrist Wednesday to try to get off Effexor because I feel horrendous.
I just feel this intense dread and hopelessness and pointlessness constantly I don’t know what to do :(
| 6 |
Is it ok to use Benzos? Whats your thought?
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So i am moving off of celexa onto Nefazodone and its been really difficult. The anxiety is getting worse every couple days. My doctor gave me .5mg of klonopin and said to take half as needed. I have been taking .125 and it has been helping me on days that i need it. However, today i dont feel like its working much.
I have never used benzos and this is my first time switching meds and its been tough. My sister said she used Klonopin for 6 weeks as she waiting for her Effexor to come on. Then she just stopped taking the Klonopin. I dont know why i am so scared. I guess i dont want another problem. Am i being too cautious? Is what the doctor presecribed me a low amount? I have to wait until next monday to meet with my doc at which point i am sure he is going to increase my Nefazodone.
| 10 |
3 weeks into 5mg lexapro and I’ve lost all emotion/motivation/pleasure. Is this how it’s supposed to work?
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Hey all. I went on lexapro for a major depressive episode that led to suicidal ideation and almost an attempt. I also have BPD so am used to large mood swings. This past week on lexapro (first antidepressant I’ve ever tried) I feel totally numb and like a zombie. Im not sad anymore, but im also not happy. Im supposed to be on sick leave for other medical issues but I can’t find pleasure in anything. Does this mean lexapro is working or not working?
| 13 |
Buspar and Zoloft
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I’m on 15 mg 3 times a day of Buspar. My doc just prescribed be 50mg Zoloft. Anyone else on this mix? Everything I read online is don’t take these two together. So my anxiety is kicking in about taking these two together.
| 2 |
A Quarter Century On SSRIs
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I had severe episodes of depression, anxiety, and insomnia starting at age 5. In 1990 they said it meant simply that I was overly sensitive due to being so ahead intellectually for my age. Looking back, I was already experiencing bipolar cycling, but only ever had very brief manic periods which usually had to do with me already being very attracted to girls and women. At 13 my Dad recognized my degree of disproportionate despair and had his doctor buddy put me on the SSRI Prozac. I should’ve instead gone to a psychiatrist weekly and probably gotten some sedatives to take no more than once every few weeks when things got overwhelming. Instead, the Prozac made me feel super stoned and happy for two days. Fast forward 25 years… I’m stable and doing well, but since my brain literally grew up neurologically relying on various SSRI’s I kept being fed and taking since I trusted my Dad, I can never get off them. The first time I tried tapering off Paxil at age 16 because I wanted to see if I’d improved, I had a fainting panic attack the day after I stopped. Then came the nervous breakdown hitting me like a truck. I’ve tried tapering off them a dozen times. Each time I have the same nervous breakdown. I vomit from anxiety, cry in sadness over nothing, my skin crawls inside and out with anxiety, my heart races. I’m moving at a million miles an hour in my mind, but too tired to get out of bed for a week, I have no appetite, no sex drive, and I’m agoraphobic. Then… 3-5 days after I get back on any high-medium dose of an SSRI - be it Luvox, Prozac, Zoloft, Paxil, or whatever they’re pushing now that those Oder ones are all generic, I feel fine. I figure I’m okay after a quarter century of taking them without raising my doses and such an obvious physical need, but I fear that they could stop working eventually. Or if we have another pandemic and the supply chain just disappears. If I ever can’t get them, I will be permanently sick to the point of needing a caregiver and not functioning at all.
| 22 |
thoughts on being on 3 different medications?
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i’m currently on seroquel 75mg and sertraline 75mg. i’ve been struggling with lack of energy and motivation so we have been talking about an option that’ll help. last week we tried to lower the seroquel to 50mg bc i want to try and get off it but i have the worst reaction the following day and felt manic, my thoughts would not stop racing it was hard to even focus on reading a sentence.
this week we decided to add wellbutrin XR 150mg and stick to the sertraline and seroquel 75mg. i’m nervous because i don’t want to be dependent on a whole other medication but i really want help with my energy. i’m also just scared on the effect on my liver taking so many medications. idk. what’s your experience?
| 2 |
Effexor Or Cymbalta
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Any idea Or experience which is better for Anhedonia , Improve motivation and Focus and ADHD : Effexor Or Cymbalta?
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