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gen_7c96d466164c7035d008dbc9753c3b91 | A framework to make more books freely available online | Arcadia Fundation | New York Public Library | 360G-ArcadiaFund-3961 | To develop technology, policies, and partnerships that will increase the amount of book content that researchers can access digitally. | Books / Strategic | 7research_infrastructure
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gen_e766ba9768dda8f43582781d89017ca7 | Core costs | Arcadia Fundation | Open Syllabus | 360G-ArcadiaFund-4313 | To enable Open Syllabus to fully explore its potential to support open learning, curricular design, student mobility, research on fields and intellectual history, and other aspects of higher education. | Other / Strategic | 4other_research_funding
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gen_c06a41a34a620854d5dba412983de5b2 | Digital Public Library of America | Arcadia Fundation | Digital Public Library of America | 360G-ArcadiaFund-3174 | To develop a working prototype of the Digital Public Library of America platform. | Other / Strategic | 7research_infrastructure
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gen_e4573a538fcd5195645f9f95b57bad84 | Towards core costs | Arcadia Fundation | Center for Jewish History | 360G-ArcadiaFund-5102 | Towards core costs | Other / Strategic | 5out_of_scope
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gen_539810c55a9ba8ce5afdd1c69dad8fc3 | Community-led Open Publication Infrastructures for Monographs | Arcadia Fundation | Coventry University | 360G-ArcadiaFund-4192 | To provide match funding for the Community-led Open Publication Infrastructures for Monographs (COPIM) project, which will address the key technological, structural and organizational hurdles - around funing, production, dissemination, discovery, reuse and archiving - which are standing in the way of the wider adoption an impact of open access books. | Books / Strategic | 6project_grants_public
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gen_992b4b660a8d4ba26ac3e861962f36d4 | Advancing open access | Arcadia Fundation | University of California Los Angeles | 360G-ArcadiaFund-3658 | To further open access to scholarly and cultural materials | Other / Strategic | 7research_infrastructure
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gen_9a39c08338b2e51970c3ec3d4c30e0ba | Halcyon Land & Sea and core support | Arcadia Fundation | Fauna & Flora | 360G-ArcadiaFund-5051 | Halcyon Programmes and core support | On-site conservation / Strategic | 5out_of_scope
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gen_17d97099b700fb6465e41bea1bb873ee | Advancing Open Access at UCLA | Arcadia Fundation | UCLA Library | 360G-ArcadiaFund-4257 | The Library plans to put this generous contribution to good use by funding the publication of open access monographs via TOME, and to further open access initiatives by membership and participation in organizations such as Libraria. | Other / Strategic | 7research_infrastructure
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gen_d23090ab89ba6bb5325d6773463248cc | Internationalization of Arches data management platform software | Arcadia Fundation | Getty Conservation Institute | 360G-ArcadiaFund-4561 | To develop a new software module for the Arches data management platform | Heritage sites / Strategic | 6project_grants_public
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gen_b00125058eb526a7c0c4cdc745ced54b | Advancing open access | Arcadia Fundation | Wikimedia Foundation Inc | 360G-ArcadiaFund-4501 | To help support general management, staff, IT equipment and training, fundraising and governance. | Other / Strategic | 5out_of_scope
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gen_d81565d35551975309d210b7b0c1dd06 | Pesticide Free Towns | Arcadia Fundation | Pesticide Action Network UK | 360G-ArcadiaFund-4669 | Supporting the pesticide free towns campaign | Governance / Strategic | 5out_of_scope
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gen_b20e3aa463dc482ab036315959c3f12f | Endangered Languages Documentation Programme | Arcadia Fundation | Berlin-Brandenburgische Akademie der Wissenschaften | 360G-ArcadiaFund-4492 | To support documentation of the most endangered languages around the world, and to archive and publish this material online in an open-access database. | Intangible culture / Grant programme | 6project_grants_public
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gen_536a50ec71b9c10feb4a26c8c1cf6f1c | Core costs of the organisation | Arcadia Fundation | Marine Conservation Institute | 360G-ArcadiaFund-2976 | To support organisational development. | Governance / Strategic | 5out_of_scope
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gen_8e479991ce7a69ca197520f9aaf809cc | Soviet Jewry project | Arcadia Fundation | Wende Museum | 360G-ArcadiaFund-4714 | Towards preserving, documenting and providing access to historical materials relating to Soviet Jewry, the Refusenik movement and the Russian-speaking Jewish diaspora | Other / Strategic | 5out_of_scope
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gen_d1b84e6efb081b2b22cd3eab375d4f47 | History of Jewish Mysticism and Esotericism | Arcadia Fundation | Zalman Shazar Center for Jewish History | 360G-ArcadiaFund-3620 | To support the research and publication of Professor Joseph Dan's multi-volume history of Jewish mysticism and esotericism. | Other / Strategic | 6project_grants_public
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gen_07ee1e1adaf795d0dc4cdeb231c37481 | Exploration and conservation of African rock art | Arcadia Fundation | Trust for African Rock Art | 360G-ArcadiaFund-2361 | To survey, document and conserve rock art sites across Africa. | Heritage sites / Strategic | 5out_of_scope
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gen_e37226b9f3b3a004eb74bce4592b2786 | Documentation of maritime archaeology in the Middle East and North Africa | Arcadia Fundation | University of Southampton | 360G-ArcadiaFund-4067 | To document endangered maritime archaeological heritage in the Middle East and North Africa and to publish the results through an online database. | Heritage sites / Strategic | 6project_grants_public
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gen_8e93f7ce24725340a334175124c65cd3 | COMMUNIA International Association for the Public Domain | Arcadia Fundation | COMMUNIA International Association for the Public Domain | 360G-ArcadiaFund-4762 | To develop policies and legal strategies to expand and strengthen the public domain, ensuring that everyone can always freely reuse public domain content. The project will also aim to develop user rights (of both individual and institutional users) to access and share content with legal clarity for the beneficiaries of exceptions and limitations. | Intellectual property rights / Strategic | 4other_research_funding
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gen_54d571e6b752b5abfb6c40dcb30ea1dd | Xarxa interhospitalària catalana de variants genètiques per millorar el diagnòstic genètic en malalties rares | La Marató de TV3 | Fundació per a la Recerca i la Docència Hospital Sant Joan de Déu - FSJD | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public
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gen_463b3768745c1c2bd73be75250a1ee4b | Chronic Diseases and Urban Health incorporating the TB case-control platform | Medical Research Council | London School of Hygiene and Tropical Medicine | HRCS22_01348 | The Chronic Diseases and Urban Health platform will support the planned work on non‐communicable diseases and emerging health risks. It will evolve from the current TB Case Contact (TBCC) platform and include existing patients’ cohorts, e.g. rheumatic heart disease, who will be visited at least once a year to collect information on (among others) environment, socio‐economic status and risk factors related to lifestyle. This platform will work as a ‘targeted’ urban health surveillance system and possibly develop into an urban HDSS. The TB case-contact platform was established at MRC in 2001 and allows multi-disciplinary analysis of TB across the spectrum of infection and disease with over 2000 TB cases and 10000 close contacts enrolled to date. The platform has generated over 120 publications including epidemiological, clinical, microbiological, and immunological investigations and is currently recruiting participants for studies on post-TB lung health, a phase III TB vaccine trial, diagnostic and prognostic analysis of TB cases and their contacts and community screening of sub-clinical TB. The CD&UH platform will include the existing cohorts of TB, chronic liver disease and rheumatic heart disease patients and patients with other chronic diseases such as hypertension, diabetes, and chronic respiratory diseases, e.g. asthma. Patients and their families will be visited at least once a year and data on demographic variables, environment, socio‐economic status and risk factors related to lifestyle, health seeking behaviour, etc. will be collected. For each patient in the cohort, we will identify three neighbouring families for which we will collect the same information. | 2.4 Surveillance and distribution / Unit | 6project_grants_public
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gen_2745c48d1a7aa57f4dd90b36a99c1cc6 | Clinical Services Department | Medical Research Council | London School of Hygiene and Tropical Medicine | HRCS22_01349 | The Clinical Services Department exists to support clinical research at the Unit by providing primary health care to staff and their family members, medical care to study participants, primary health care to the population of West Kiang, and access to paediatric and internal medical services to the general public. Both outpatient and inpatient services are offered at the Fajara site. The Department supports research with specific clinical skills, such as ultrasound, GI endoscopy and bronchoscopy. More intensive studies are hosted in the ward. Alongside this, the Department supports local healthcare training institutions by providing clinical attachments to all levels of nursing students, medical students and doctors in training. The department focuses on Quality Improvement in healthcare, with an active programme of projects aimed to improve the care delivered in the department. A suite of guidelines have been developed and are publicly available. We have developed an electronic medical record system, which enables us to record clinical activity for day-to-day operational reasons, but also gives us access to data that can be used to improve quality and to better understand the conditions seen in the Department. The Department hosts small research projects which answer questions that arise during clinical practice. Examples have included studies of the relationship between respiratory illness and air quality, validation of a locally produced buffer for a point of care test and a study of antimicrobial usage. Collaborations are sought with organisations and individuals who can further the objectives of the Department, particularly when they are able to offer skills which are not currently found within the Department. | 8.1 Organisation and delivery of services / Unit | 2institutional_funding
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gen_52574e7b0e17af31763613b01a6bbfd5 | Health and Demographic Surveillance System | Medical Research Council | London School of Hygiene and Tropical Medicine | HRCS22_01350 | The Unit maintains three Health and Demographic Surveillance Systems in Basse, Farafenni, and West Kiang. The HDSS collects data on vital events, namely births, deaths, migrations, pregnancy, educational level, ethnicity, vaccination status, socio economic status and cause of death (through Verbal Autopsies) using the electronic data capture (EDC) method via RedCap application. We aim to provide baseline data, sampling frame and identify clinical cases/study subjects to scientists for community-based research. We also provide a denominator for estimating impact studies, generate longitudinal information on the health of the population and provide quantitative evidence for scientific investigations as well as monitor demographic and mortality trends in populations. | 2.4 Surveillance and distribution / Unit | 7research_infrastructure
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gen_d9de690a4243d131c848b603896df46c | Research Services Theme | Medical Research Council | London School of Hygiene and Tropical Medicine | HRCS22_01351 | This is part of the Research Services Theme. This project focuses on Research Services and is made up of three elements, namely Research Services - Data Science Research Services - Governance and Research Support Research Services - Laboratories | HRCS Research Uncodeable / Unit | 2institutional_funding
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gen_c11467a94f6813fa262b65ab95f8716a | Skills Developments Grant - Travel award - Advances in Ewing Ssarcoma Research conference 14 October 2022 | Bone Cancer Research Trust | University of Padua | HRCS22_11821 | Oral presentation: Autoantibody Profiling in Ewing Sarcoma Patients | 4.1 Discovery and preclinical testing of markers and technologies | 1fellowships_scholarships
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gen_55c53fc9813d4f982513e0607f9b4936 | Skills Developments Grant - Travel award - Advances in Ewing Ssarcoma Research conference 14 October 2022 | Bone Cancer Research Trust | German Cancer Research Center | HRCS22_11826 | Oral presentation: Neomorphic DNA-binding enables tumour-specific therapeutic gene expression in fusion-addicted childhood sarcoma | 5.2 Cellular and gene therapies | 1fellowships_scholarships
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gen_5bf93fe5b9c56dbeb4be699c15b9fc99 | Skills Developments Grant - Travel award - Advances in Ewing Ssarcoma Research conference 14 October 2022 | Bone Cancer Research Trust | Istituto Ortopedico Rizzoli | HRCS22_11852 | Oral presentation: Triggering CD99 impacts on the macrophage functions and favors their role in tumor cell eradication | 5.2 Cellular and gene therapies | 1fellowships_scholarships
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gen_0dded0ebb290654ad7ef38cf2347167a | Skills Developments Grant - Travel award - Advances in Ewing Ssarcoma Research conference 14 October 2022 | Bone Cancer Research Trust | CERCA Institution | HRCS22_11853 | Oral presentation: KDM6 demethylases of H3K27 residue regulate critical transcriptional programs induced by EWSR1-FLI1 in Ewing sarcoma | 2.1 Biological and endogenous factors | 1fellowships_scholarships
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gen_f03cecc8c0e0d0daad34c40b7a88f94a | Skills Developments Grant - Travel award - Advances in Ewing Ssarcoma Research conference 14 October 2022 | Bone Cancer Research Trust | Essen University Hospital | HRCS22_11866 | Poster presentation: Preclinical testing of lestaurtinib (CEP701) as a single and combination agent for the treatment of Ewing sarcoma | 5.1 Pharmaceuticals | 1fellowships_scholarships
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gen_56915d5cbca4e22ff27cb90b0dc69078 | Open access fee for terminated award 106854/Z/15/Z | Wellcome Trust | Tulane University | HRCS22_11946 | No abstract available for this analysis | HRCS Research Uncodeable | 4other_research_funding
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gen_be87a95a27007369ef68697b876e4568 | Open access for Innovator Award | Wellcome Trust | SurgiBox Inc | HRCS22_11948 | No abstract available for this analysis | HRCS Research Uncodeable | 0business_rnd_innovation
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gen_ad1491f224129efd8f6fcf3ca9ba70bb | Open access for terminated award 109164/Z/15/Z | Wellcome Trust | University College Dublin | HRCS22_11949 | No abstract available for this analysis | HRCS Research Uncodeable | 6project_grants_public
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gen_ea6a893f1b844e5594ef9ffc9936555d | Open access fee for terminated award 084754/Z/08/Z | Wellcome Trust | Stanford University | HRCS22_11951 | No abstract available for this analysis | HRCS Research Uncodeable | 4other_research_funding
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gen_233b43c6b0cf9c85897512d09f84004f | Open access fee for Innovations grant 215695/B/19/Z | Wellcome Trust | University of British Columbia | HRCS22_11962 | No abstract available for this analysis | HRCS Research Uncodeable | 4other_research_funding
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gen_774d94a1a978f15cf38cddd6d179cac3 | Keith Yeates/Shackman Award | The Urology Foundation | Unknown | HRCS22_11984 | Prize award - Visit to memorial Sloan Kettering Cancer Center, NY | HRCS Research Uncodeable | 5out_of_scope
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gen_dd707d191cec77f522f7764d560b5501 | Open access for terminated award 200253/Z/15/Z | Wellcome Trust | Syracuse University | HRCS22_11999 | No abstract available for this analysis | HRCS Research Uncodeable | 5out_of_scope
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gen_b74371b5290f6e21126c55ce0aa41c22 | Open access for terminated award 071613/Z/03/Z | Wellcome Trust | Telethon Kids Institute | HRCS22_12001 | No abstract available for this analysis | HRCS Research Uncodeable | 6project_grants_public
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gen_22385fc0313fb51823082fd2aadf54e1 | Open access for terminate award 219600/Z/19/Z | Wellcome Trust | University of Cape Town | HRCS22_12043 | No abstract available for this analysis | HRCS Research Uncodeable | 6project_grants_public
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gen_359e5ea5fed586be712e4751c89aa24a | Open access for terminated award 214461/Z/18/Z | Wellcome Trust | Dublin City University | HRCS22_12070 | No abstract available for this analysis | HRCS Research Uncodeable | 5out_of_scope
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gen_f4896654b1a46f7e3e85f456615ac940 | Open access for terminated award 107591/Z/15/Z | Wellcome Trust | University of Auckland | HRCS22_12105 | No abstract available for this analysis | HRCS Research Uncodeable | 6project_grants_public
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gen_c0a150fd066bc38fc7a396d7884795bc | Exploratory development of Aleta-001 (CD19-CD20 bridging protein) for a first in human clinical trial | Cancer Research UK | Aleta BioTherapeutics | HRCS22_12194 | Chimeric antigen receptor (CAR) therapy involves isolation of patient T cells followed by viral-mediated gene insertion and T cell expansion in culture. The resulting CAR T cells are infused into the patient. Patient T cells that express an anti-CD19 scFv chimeric antigen receptor (anti-CD19 CAR) can elicit durable and curative responses against CD19-positive B cell malignancies. However, up to 60% of patients who initially achieve a beneficial clinical response to this therapy relapse afterwards. Relapses typically happen in the first few months after therapy is administered. Relapses occur when the CAR T cell population does not achieve optimal expansion and persistence after administration. T cell expansion and persistence require the availability of the CD19 antigen on the tumor cells and on normal B cells. In some patients the initial T cell expansion fails to eradicate all of the tumor cells, so they achieve a partial clinical response or, a complete clinical response is achieved, but CAR T cell number in circulation is below optimal. These patients will relapse. In some patients the expression of CD19 is lost from the tumor cells, which therefore become invisible to the CAR T cells. These patients will also relapse. Aleta-001 is a CD19-anti-CD20 biologic designed to optimize anti-CD19 CAR T cell activity by creating a novel source of CD19 on the tumor cells. All NHL patient tumor cells are CD20-positive and the biologic binds to this CD20 with high affinity. In the case of suboptimal CAR T cell expansion, the biologic provides higher CD19 antigen density on the targeted cells to optimally stimulate the CAR T cell population. In the case of CD19 antigen loss, the biologic replaces CD19 via anti-CD20 binding, providing a de novo antigen source. This biologic is the only therapeutic specifically designed to optimize anti-CD19 CAR T cell therapy. The modality offers the clinician and patient a ready solution that can be administered by injection to optimally activate or reactivate the CAR T cell therapy the patients has already received. The goal of the proposed collaboration with CDD is to fund early phase clinical trials at UK cell therapy centers of excellence. The clinical trials of this novel therapeutic will demonstrate safety and measure PD markers of response to treatment. Ultimately this funding will help us improve patient outcomes in the setting of anti-CD19 CAR T cell treatment of advanced B cell cancers. | 6.1 Pharmaceuticals | 0business_rnd_innovation
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gen_6c8e8c4e5e64ad9fd96586ea5315c0e7 | Open access for terminated awarded 087547/Z/08/Z | Wellcome Trust | African Population and Health Research Center | HRCS22_12202 | No abstract available for this analysis. | HRCS Research Uncodeable | 5out_of_scope
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gen_bf54e51d507a8e793f5e046c9c117647 | Engaging with Local Communities in Botswana: Understanding Cultural Values, norms and Beliefs that may impact Genome-Editing Research in Botswana | Wellcome Trust | University of Botswana | HRCS22_12260 | The continuous growth and recent technical advances that have improved the precision, cost and simplicity of new gene editing technologies such as Somatic and germline therapy have since given birth to new hope in the fight against the burden of disease such as HIV in developing countries (sources). Despite facing dis-proportionally higher prevalence HIV rates, communities in Botswana to our knowledge the technologies have not been tried hence Batswana remain understudied in gene editing research. Therefore, I am proposing a study to engage with local communities to educate them about gene-editing technology research and collect their perspectives on how their cultural values norms and beliefs can have positive or negative implications on their benefiting from this technology. 1. The overall goal of the project is to explore the perceptions of communities in Botswana regarding perceived and real social ethical issues (cultural values, norms and beliefs) surrounding gene-editing technologies regarding its use for health benefits? 2. The project also aims to empower communities with knowledge through education and engagement about gene-editing technology for better informed decisions in preparation for participation in gene-editing technologies as well as learning about its potential benefits, risks and use of genomics, gene-editing technologies. | 8.3 Policy, ethics and research governance | 6project_grants_public
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gen_e37866562423dd7d0cb619eb8f6fb0b7 | Re-Mix: Design Workshops for Accessible, Usable, and Inclusive Environmental Data Sets | Wellcome Trust | Open Environmental Data Project | HRCS22_12442 | No abstract available for this analysis. | No Research Activity assigned | 7research_infrastructure
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gen_c2b9422e284f61b4f848075f6ab2dc15 | Bringing data science and AI/ML tools to infectious disease research - a hands-on workshop | Wellcome Trust | H3D Foundation | HRCS22_12443 | No abstract available for this analysis. | No Research Activity assigned | 6project_grants_public
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gen_bfa148a081deecd47afc261a17aee5b9 | Girls in Asia Datacamp (GiAD) | Wellcome Trust | University of Technology Sarawak | HRCS22_12444 | No abstract available for this analysis. | HRCS Research Uncodeable | 5out_of_scope
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gen_de8c3e4b53024c60eade0737c331d920 | Characterizing the Impact of Antenatal Maternal Anaemia on the Child Brain using Magnetic Resonance Imaging (MRI) in Two South African Birth Cohorts | Wellcome Trust | University of Cape Town | HRCS22_12596 | My research is embedded within two South African birth cohorts with numerous risk factors for poor child development including food insecurity, malnutrition, and anaemia. Preliminary work indicates a 31% prevalence of maternal anaemia. Given that iron deficiency is the most common global cause of anaemia, nutrition is recognised as a health priority to target in educating and empowering communities. I have developed a three-tier public engagement project. The first objective is to run interactive workshops with mothers from study communities. The aim is to identify practical ways to improve research processes, to gain insight into community perceptions and challenges around nutrition, to collaboratively develop key messages and strategies for improved iron intake, and to discuss prospective methods for sharing study outcomes with the wider community. The second objective will focus on using workshop feedback to create accessible, informative, and culturally appropriate resources for dissemination at study sites and more broadly to the South African public. Resources will include posters, pamphlets, and a video aimed at raising awareness and providing practical guidelines around the importance of a nutritious, iron-sufficient diet. The goal is to make these resources accessible via antenatal clinics, study sites, community resource centres, institutional websites, social media platforms, and government endorsed mobile healthcare platforms. Tier three involves sharing research results through academic platforms and community meetings for feedback and discussion with study participants. I also aim to prepare an article for a popular science magazine that is accessible to the general public including the South African youth. | No Research Activity assigned | 6project_grants_public
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gen_2d859c85bff7c5aa5923dd6313213a15 | Energy Systems That Protect Climate and Health in South Africa | Wellcome Trust | Public Health Association Of South Africa | HRCS22_12625 | We aim to primarily disseminate HCN’s messages on Energy Systems That Protect Climate and Health to government and civil society so as to promote health- centred climate policy and advocacy in South Africa.Expected outcomes: • A database of audiences for a targeted dissemination campaign; • a social media campaign about the key HCN messages; • press releases with AMREF and the SA Medical Association; • monthly webinars about climate and health at COP26; • regular engagement with HCN global partners in the run up to COP26; • a published journal paper about the campaign; • an online resource for public health educators and professionals about protecting public health from climate change, and educating for sustainable healthcare, which incorporate key HCN policy messages. These will support HCN’s intended short-term outcomes by enhancing collaboration between health and non-health advocacy organisations in SA; disseminating key messages of HCN briefs to key target audiences; and strengthening the capacity of PHASA as a champion for health- centred climate policy and advocacy in SA, especially with respect to energy policy. | No Research Activity assigned | 5out_of_scope
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gen_9a218473ed39ac54372f1309de5b5a5b | Dissemination of the Health and Climate Network briefs in Vietnam | Wellcome Trust | Research and Training Center for Community Development | HRCS22_12675 | NCDs-VN (hosted by RTCCD), together with other national partner NGOs, is poised to establish a CSOs-One Health and Climate Change Partnership (CSO-OHCCP) to increase government action and coordination on health and climate change. The CSO-OHCCP will use the HCN policy briefs and recommendations as a basis for engagement with Vietnamese government ministries to influence key policies relating to health and climate change, and will work closely with national government delegates attending COP26 to encourage incorporation of HCN policy priorities into national negotiating positions. This will be achieved through the translation of materials, organisation of meetings and events for both civil society and government, policy submissions to government, and accompanying communications campaigns, as well as direct participation in the Vietnamese COP26 delegation. Through this work, civil society organisations working across health and environmental issues in Vietnam will become united and better coordinated and will continue to advocate on health and climate change in months and years to come. RTCCD/ NCDs-VN will be responsible for overall management and delivery of the project, and makes this proposal for activities with a budget of 20,000 GBP. | No Research Activity assigned | 5out_of_scope
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gen_d8de54a316f6630247b7b46dd2c11f41 | Dis-Ease | Wellcome Trust | Indexical Films LLC | HRCS22_13137 | Declaring “war on disease” affects how we treat sick people, how we define the “public” in public health, and how we respond to real-world pandemics.. This was demonstrated vividly during the COVID-19 crisis, when these declarations of war initiated militarized states of emergency, prompted border lockdowns, and refreshed old fears about “foreign” pathogens. But why was this public health crisis being treated as a national security issue? What else does this metaphor do in the world? And what if it weren't a war? To answer those questions, the feature-length documentary “Dis-Ease” retraces the origin and evolution of our “war on disease” through the history, philosophy, culture, and pop-cultural imaginaries of medicine. It is constructed around particular episodes in the history of human encounters with epidemic, endemic, and pandemic diseases, including plague, malaria, cholera, tuberculosis, influenza, HIV/AIDS, and COVID-19. By examining the cultural history that runs alongside the growing scientific understanding of these diseases over time, DIS-EASE looks to understand how pandemic preparedness became framed as biodefense, and how that has contributed to the present crisis. And it proposes alternatives for the future. | No Research Activity assigned | 5out_of_scope
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gen_1b67f0e2389853295f5c0309011b056d | Saving young lives: Triage and management of sepsis in children using the point-of-care Paediatric Rapid Sepsis Trigger (PRST) tool | Wellcome Trust | University of British Columbia | HRCS22_13150 | Smart Triage represents a significant shift in the care provided at Ugandan health facilities. Previously, children were seen on a first-come, first-serve basis. With Smart Triage, children are stratified by severity of illness to guide prioritization of care to the sickest children. This change in practice is unexpected for families. Sustaining impact beyond our research award will require acceptance and cooperation from caregivers and family of children who present to health facilities and the general public who become participants within this new system. Here we aim to sensitize caregivers and community members to Smart Triage and its impacts on the care provided at Ugandan health facilities. We will host community dialogues with caregivers, community leaders, and Village Health Teams (VHTs) to provide details of the motivation for Smart Triage and outcomes to-date and gain feedback the system. These discussions will inform the development of educational materials on the role of Smart Triage and the importance of triaging in reducing death and improving outcomes for vulnerable children in Uganda. We will engage with VHTs to broadly distribute these materials to caregivers across one district in which we operate. VHTs are trusted community members that serve as link between caregivers and the formalized health care system. We will monitor caregiver awareness of Smart Triage when they arrive at health facilities before and after our campaign to assess impact, and host additional community dialogues to help refine our approach. This approach will then be replicated in more districts. | 7.1 Individual care needs | 6project_grants_public
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gen_0b81112d2002381c7d26f0937fdd73cb | Improving clinical handovers and communication to improve continuity of care for hospitalized small and sick newborns in selected public hospitals in Kenya. | Wellcome Trust | KEMRI Wellcome Trust Research Programme | HRCS22_13437 | Clinical handovers involve transferring patient responsibility and accountability between outgoing and incoming healthcare providers across shifts and disciplines. It has been highlighted as the most vulnerable time in patient care. Communication failures during handovers have been linked to adverse events, jeopardizing patient safety. Many techniques have been used to improve handovers and communication in health care settings in High Income Countries (HICs) often focused on standardizing information transfer. The SBAR (Situation, Background, Assessment and Recommendation) structured handover approach is often regarded as a ‘best practice’ technique in critical care that has led to reductions of medical errors and enhanced safety culture. In LMICs, including Kenya interventions to improve handovers have not been implemented. In this study, focusing on neonatal ward care I propose: i) to systematically review tools used to improve and evaluate effects of handover interventions, ii) explore current Kenyan nurses’ handover practices and develop with them a contextually appropriate tool to improve and standardize handovers and, iii) to conduct a pilot implementation study using mixed methods (focus group discussions and a survey) to assess its potential effectiveness. This fellowship will then provide the preliminary evidence needed to inform the design future funding proposals for larger implementation studies. | 8.1 Organisation and delivery of services | 6project_grants_public
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gen_e86b367abe7fcb3f408744f6a0c9ecff | Transparent Peer Review for Open Science and Research Assessment | Wellcome Trust | European Molecular Biology Organization | HRCS22_13833 | A scaleable, interoperable mechanism to establish transparent peer review in scientific journals and preprints as a standard optimized for the browsing, interpretation and assessment of research papers and preprints. The proposed tools and standards will allow inclusion of peer review formally in research assessment by funders and research institutions. | No Research Activity assigned | 7research_infrastructure
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gen_028d098f9ad83e536bf1154e2ef849f6 | NURTuRE: National Unified Renal Translational Research Enterprise - Geneva University Hospitals | Kidney Research UK | University of Geneva | HRCS22_14608 | No abstract available for this analysis. | HRCS Research Uncodeable | 6project_grants_public
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gen_ee99db15268c14644c11dd57e6048082 | NURTuRE: National Unified Renal Translational Research Enterprise - Geneva University Hospitals | Kidney Research UK | University of Geneva | HRCS22_14727 | No abstract available for this analysis. | HRCS Research Uncodeable | 6project_grants_public
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gen_22cf382157d810dd644be4fbb1309735 | Secretariat Support for G20 High Level Independent Panel (HLIP) | Wellcome Trust | National Academy of Sciences, America (NAS) | HRCS22_16188 | The G20, as proposed by the Italian G20 Presidency, has mandated a High-Level Independent Panel (HLIP) to recommend actionable solutions for reliable and sustainable financing of the global commons for pandemic prevention, surveillance, preparedness and response. The Panel’s recommendations will be presented to the G20 Finance Ministers and Central Bank Governors Meeting in July. To provide the HLIP with support for logistics, coordination, outreach, and communication/engagement, The National Academy of Medicine (NAM) proposes to establish a joint Secretariat comprised of 4-5 individuals from the NAM and the Wellcome Trust. From February through October 2021, it is expected that the joint Secretariat will support the execution of the independent review by the HLIP. The work of the Secretariat during these eight months will include: 1) meeting logistics and organization; 2) meeting facilitation (agenda setting, conduct, and procedures); 3) outreach and communication with key political and other stakeholders; and, as needed 4) limited research/analytical/writing support for health-related content. | No Research Activity assigned | 5out_of_scope
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gen_a4400c8fd962df44df2cc5a785dc3135 | Repurposing two JAK inhibitors as a treatment for DMD | Duchenne UK | AGADA Biosciences | HRCS22_16291 | Test whether treatment with JAK inhibitors (Tofacitinib and Ruxolitinib) improves muscle function and histology in mdx mice. | 5.1 Pharmaceuticals | 0business_rnd_innovation
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gen_c2a33f55c67cbc281729a6d803254022 | Civil Society Consultation and Engagement in the Design, Start-Up, and Governance of the Financial Intermediary Fund for Pandemic Prevention, Preparedness and Response | Wellcome Trust | Panorama Global | HRCS22_16432 | Lead CSO consultation and engagement in the design, start-up and governance of the Pandemic Fund Enable diverse, meaningful, and timely CSO engagement in strategy and decision-making during the design and start-up phases of the Fund to build support and improve its governance, and impact. Activities/Outputs • Series of multi-stakeholder consultations to inform Fund design and decision-making, in partnership with two or more Southern-led CSOs or networks, producing written outputs which summarize the consultations. • Online portal to provide timely information on the evolving design and activities of the Fund, to serve as a go-to resource for CSOs and other stakeholders seeking to engage in Fund-related advocacy. • Rapid selection process, in partnership with two or more Southern-led CSOs or networks, to identify two interim CSO representatives and two alternates to serve on the Fund’s governing board. • Briefings and technical assistance for the interim CSO representatives to prepare for and support their engagement in meetings and decisions of the Fund’s governing board, including ongoing consultations to solicit input from CSOs across the global North and South. • Proposal for a permanent CSO engagement hub and CSO representative selection process for the Fund, based on best practices and learnings from other global financing mechanisms | No Research Activity assigned | 5out_of_scope
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gen_4376b1a33d7fbfb59554d6d12a71ba2c | Metabolic and Cardiovascular Disease. | Wellcome Trust | University of Cambridge | HRCS22_20518 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public
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gen_aade94a41a134e25aba7175738408146 | Cellular and molecular physiology | Wellcome Trust | University of Liverpool | HRCS22_20531 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public
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gen_ea0ce3078f408b308b47116358f22cad | The molecular basis of biological mechanisms | Wellcome Trust | University of Leeds | HRCS22_20548 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public
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gen_927f97882e564e4f7c8b033aa4323674 | Hosts, Pathogens & Global health | Wellcome Trust | University of Edinburgh | HRCS22_20549 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public
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gen_3ff2ac3f510d64074b67fbd488443c66 | Cellular Structural Biology | Wellcome Trust | University of Oxford | HRCS22_20561 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public
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gen_df47e8da2ec41ae198f29394d6ee3911 | Macromolecular machines: interdisciplinary training grounds for structural, computational and chemical biology | Wellcome Trust | University College London | HRCS22_20573 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public
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gen_3c778241a7ed637086b7c866aba214a3 | Dynamic Cell Biology | Wellcome Trust | University of Bristol | HRCS22_20597 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public
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gen_6a25b00415b7c5282e7dd3dc37524292 | Molecular and Cellular Biology | Wellcome Trust | University of Dundee | HRCS22_20599 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public
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gen_a95f22b13911d87dce22e629979938fb | Genomic medicine and statistics | Wellcome Trust | University of Oxford | HRCS22_20607 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public
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gen_97ab4e7df274892b88100ddd093036a5 | Infection, Immunity and Inflammation | Wellcome Trust | University of Cambridge | HRCS22_20620 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public
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gen_8f3df496c9220c6d96f7abd3432d2ddb | The Dynamics of Cellular Regulatory Networks | Wellcome Trust | University of Manchester | HRCS22_20632 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public
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gen_d7a0bc4bbde97637d30665e0e45eb2e6 | Chromosome and Developmental Biology. | Wellcome Trust | University of Oxford | HRCS22_20638 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public
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gen_b0eea513fabc19b7ce52c15c2261516e | Developmental mechanisms | Wellcome Trust | University of Cambridge | HRCS22_20646 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public
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gen_f6630897fd592950c5e7e7e0a51479ac | Neuroscience | Wellcome Trust | University of Oxford | HRCS22_20687 | No abstract available for this analysis. | Missing/Incomplete | 5out_of_scope
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gen_9433ae64d91802bc390e46dd380b7d0a | ENTHUSE Charitable Trust Proposal to The Welcome Trust, May 2021 | Wellcome Trust | ENTHUSE Charitable Trust | HRCS22_20728 | The ENTHUSE Charitable Trust's charitable purpose is to improve science education, or related subjects, for young people, through the professional development of teachers. Over the period to 2023, ENTHUSE will: • continue to provide science CPD accessible by all teachers and others from state-funded schools, with a particular focus on engaging schools, colleges, teachers and young people most in need of STEM education support so helping close the achievement gap and promote social mobility while raising standards across the board; • build strong, visionary leadership in STEM teaching across primary, secondary and post-16 settings to achieve sustained system-wide improvement, raising standards and expectations; • encourage a culture of career-long, STEM-specific professional learning across the teaching profession, raising morale, and enhancing retention; • significantly raise awareness among schools, colleges, teachers, young people and families of the value of STEM study and STEM-related research and careers, and of the academic, technical and apprentice routes into those roles. The ENTHUSE Charitable Trust is seeking a budget of £3.136m, with the deployment of Wellcome funding part of a wider mix of income, aligned to the above priorities. | Infrastructure | 5out_of_scope
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gen_206f9fda24d1a612dfb61e19192c458d | Drug Discovery and Team Science | Wellcome Trust | University of Nottingham | HRCS22_20837 | This programme focuses on the application of a multidisciplinary Team Science approach to develop novel approaches and technologies involving the physical, biological and medical sciences to study membrane receptors in the right cell type and tissue. The programme embraces colleagues from UoN, pharmaceutical companies, SMEs and learned societies to develop a training programme that has the student at its centre but which engenders a collaborative multidisciplinary approach within a cohort-based programme of research. Each entry of four students will study one of the following disease-related themes: (a) cancer angiogenesis; (b) pain and addition; (c) respiratory diseases; (d) immune-oncology and (e) inflammation. Each cohort will tackle their given disease theme as a multidisciplinary team, with each student working in one of four key experimental areas: (a) Target engagement; (b) cellular environment; (c) in vivo and ex vivo models and (d) mathematical modelling and systems biology. The key programme goals will address: (1) the major skills gaps identified by ABPI in complex in vivo experimental models and in vitro pharmacological analytical approaches; (2) the need for multidisciplinary programmes, industrial/transitional placements and the provision of training in ‘translational’ skills such as communication, leadership and entrepreneurship; and (3) the need for supportive training environments. | Studentships | 1fellowships_scholarships
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gen_377b53607bd80292b168fed48891b383 | Vietnam Africa Asia Programme Core Grant Renewal, 2022 to 2029 | Wellcome Trust | University of Oxford | HRCS22_20998 | Our ten-year vision is to have local, regional and global impact on health by leading a locally driven research programme on infectious diseases in Southeast Asia. We will deliver our vision by fulfilling four aims: Aim 1. Reduce the burden of infectious diseases through research Aim 2. Strengthen our research culture Aim 3. Strengthen our networks and partnerships Aim 4. Increase the local, regional, and global impact of our research Our dominant activity will be research (aim 1), with its delivery, relevance, and sustainability supported by aims 2 and 3, and its impact secured by aim 4. We will achieve our aims through a collaborative network of multidisciplinary researchers in Vietnam and Indonesia, capable of responding rapidly to escalating infectious disease threats and implementing science-led change within health systems. Our research priorities are: • New and re-emerging infectious diseases • Drug resistant infections • Climate change impact on infectious disease epidemiology • Development and implementation of new health technologies We will ensure that our research priorities and activities remain locally relevant and sustainable through extensive public and community engagement. We will strengthen our research culture, and nurture the careers of local researchers and operational staff, supporting their development and promoting their leadership. | Infrastructure | 2institutional_funding
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gen_dbed77c14c8ce5ed844e399abac92d5d | SaddleSpur: Physiology research into providing lower lumber support for cyclists | Innovate UK | Darius Development Limited | HRCS22_21355 | An innovative bicycle saddle, which provides padded lower lumbar support for enhanced comfort and performance. The patented, redesigned, cycle seat ("SaddleSpur") provides a padded, vertically curved saddle extension, which prevents the coccyx and buttocks from sliding backwards, whereby providing a fulcrum from which the cyclist can transmit more pressure and force through their legs. Whereas every other component of bicycles has been redesigned and re-engineered over the past 100 years, the bicycle seat design has received far less attention. SaddleSpur incorporates some of the latest design features, plus the patented saddle extension, for both male and female cyclists. This "coccyx connection" completes the five touch points of cycling to provide a secure fulcrum to enable more power to be transferred through the legs, whereby increasing cycling performance and reducing the potential for lower back pain. This research project is designed to identify and quantity the performance improvements of the revised bicycle seat design by a series of structured tests for male and female cyclists over varying distances (10, 20, 40, 60 and 100 miles) with varying undulations. Bio-metric statistics will be recorded for each distance for each cyclist using existing saddle design. and the revised, SaddleSpur, design, and compared to quantify the cardiorespiratory difference, with other bio-metric statistics. The testing, to be conducted by a UK, acclaimed sports medicine academic institution, will be published in scientific and academic journals, and form the basis for an introductory SaddleSpur marketing program early next year - focussed on pleasure, leisure, cycling club enthusiasts, internationally. | Missing/Incomplete | 0business_rnd_innovation
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gen_430f5a34e0ce06be1499da7db4251edb | Fuelling well-being, self-care and independence for seniors through crowd-based funding stream | Innovate UK | Deliberate Impact Ltd | HRCS22_21358 | One of the greater challenges in society currently, is the changes in demographics. The number of seniors increases rapidly (absolutely and relatively, that part of the total population), and with this change comes also a natural increase in the need for support. As many of the age-related disorders are created by inactivity, rather than age itself, there is a need to focus on habilitation more than rehabilitation, prevention rather than "repairs", self-care and independence rather than being productive within hospitals. The social care system in the UK is stated to be under severe crisis, with the Covid pandemic amplifying the situation. The Health Foundation estimated already back in 2019 (pre-covid) a shortage of up to £10bn by 2023 if we are to meet the demand pressure of the population, and the continuous cut in budgets for the past 15 years is said to result in deterioration of health and low quality of life for millions of people. The focus of public funds coming into the senior sector is on the sheer basic medicinal and health-related needs, downplaying or ignoring most initiatives and programmes that could have been successful in preventing disorders and health-related problems in the first place - be that physical illnesses or mental challenges. We propose an entirely new approach to funding streams to support initiatives and programmes that will aid seniors to be healthier longer, and hence increase independence and well-being and general quality of life. We will build a revolutionary crowdsourcing - crowdfunding platform for impact and sustainable change. The Takk! platform empowers the crowd to instigate and influence initiatives for making people's lives better. The platform is purpose-driven and it allows for donations, membership and impact investments. This will enable online donations from private individuals which are amplified with matching donations from partners, targeted to the specific initiatives and programmes (available in the platform). In sum this will increase activity and quality of life, and so help seniors to stay independent and healthier longer. By taking part in the initiatives, the seniors will increase self-care and build resilience to illness, whether that is of a physical or a mental nature. | Missing/Incomplete | 0business_rnd_innovation
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gen_e1d4f2aa17a67c01044ceb99c1f93c62 | Bruadar, The Virtual Companion | Innovate UK | Litha Group Ltd | HRCS22_21587 | This project is to take our research in psycholinguistics and design the architecture for a human-like memory to enrich the quality of human-computer interactions in such fields as mental health issues, loneliness, and neurodegenerative diseases such as Alzheimer's. | Missing/Incomplete | 0business_rnd_innovation
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gen_90469802296f8437c9119573369daf64 | Risk Assessment for Data related Hazards in Healthcare Equipment and Infrastructure | Innovate UK | Mission Critical Applications Limited | HRCS22_21643 | Modern computer systems increasingly use data to make safety-critical decisions. Healthcare systems are particularly dependent on data, as they act on data flows between organisations, and between healthcare professionals and patients in the community. The rollout of healthcare further into the community introduces additional uncertainty about the quality of the data. Tuus, the trustworthiness of the data itself, and the robustness of the equipment and the computerised infrastructure to incorrect or inappropriately used data, has become vital. The systems need to be designed in such as way as to prevent or reduce the likelihood of harm arising from the very data that is meant to improve clinical safety outcomes. There have already been a number of accidents and incidents across all industrial sectors, including healthcare, where data, as distinct from purely software and hardware, has been a major contributory factor. This problem will get worse as our systems become more dependent on data from diverse sources, more inter-connected, and using data not collected by healthcare professionals. This data might be fed into AI systems and even autonomous systems with wide-ranging consequences, which might not be easily traced back to the erroneous data. The UK Safety Critical Systems Club has created a Data Safety Guidance document, which is widely regarded as describing the current best practice of Data Safety Assessment. This has led to its inclusion in NHS Digital's own guidance on Data Safety. We have developed a proof-of-concept software demonstrator tool under a grant from the Lloyd's Register Foundation, that guides a practitioner through the Data Safety assessment process, and records the analysis and decisions made by the practitioner, to form the core of a Data Safety argument that could be given to a regulator or commissioning organisation. Our current Data Safety tool is industry-agnostic. This project aims to evolve the tool to remove a current restriction, to validate it in the healthcare domain, and understand the customizations that would be needed to deploy it into this domain. We also plan to promote the issues and solutions to Data Safety at some workshops. | Missing/Incomplete | 0business_rnd_innovation
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gen_12ef6ac6085fbc892022894fc4088d1a | Modular terraced housing for older residents of rural areas | Innovate UK | Rural Design Centre Limited | HRCS22_21849 | Issues around availability of suitable housing in rural areas are well documented and have become more pressing in recent times. Purchase of homes as second homes and holiday lets has reduced availability and increased prices, whilst the recent trend for relocation from urban areas to desirable rural communities, driven by increased homeworking, has also had an effect. Even before COVID-19, the number of homeless families was increasing rapidly in rural England (CPRE data) and demand outstrips supply. Longer term, ageing demographics of rural areas has increased the volume of housing required for a given population and changed the ideal layout of properties. Older people without families do not necessarily need or desire large properties, which can be more expensive to heat and maintain and may not fit individual access requirements. However, the build rate of bungalows, for example, has been far behind demand. The impact of planning rules and commercial pressures means that bungalow construction has been falling, with an 80% decrease from 2000 to 2020\. Given the challenges around land values, planning and community acceptance of new developments, we need new solutions to this problem. Our premise is that by creating low cost, energy-efficient but desirable single story housing at sufficient density, we can create capacity for older people to move into appropriate accommodation whilst freeing up homes for younger families. The initial thinking is to build on learning from traditional low rise miner's homes and more recent sheltered housing developments but utilise the latest concepts in modular construction to deliver on energy efficiency and cost targets. We envisage a modular courtyard-style development of one and two bedroom terraced homes. Our concept is that the community feel provided by a courtyard development of 10-20 properties will be attractive to the target group whilst still allowing a high enough density of housing to overcome land availability issues and allow use of smaller brownfield sites. The lead organisation is the Rural Design Centre. The Centre was set up as a not-for-profit company with support from key rural organisations like the NFU, CLA, local authorities and LEPs, community networks and business groups to take a new human-centred, design-led approach to rural issues. We use design thinking methodologies to bring together communities, businesses, public authorities and researchers to co-design solutions to rural challenges. We have a team of design associates and innovation managers, with experience of product, service and process design. | Missing/Incomplete | 0business_rnd_innovation
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gen_85f04a338fb910435d70633a016ce51f | ALIVE: Avatar Learning Impact assessment for Virtual Environments | Innovate UK | Sublime Digital Limited | HRCS22_21909 | Currently, accurate representation of physical spaces and, especially, human interactions in Virtual Reality (VR)can often feel clunky, unrealistic and require specialist knowledge and development. Our project will explore avatar use through the Unreal Meta Humans tool (an extraordinary new 3D character creation technology), specifically, testing the use of realistic avatars in soft skills training and social interactions. We will use this grant to generate ideas that address this gap in knowledge, and do fast, low-cost prototyping and user testing to further our understanding of the field. We will build and test a variety socially impactful scenarios (ranging in complexity intra- and inter-personal relationships) in VR and attempt to understand how these avatars are perceived. We will investigate whether the realism of the avatar impacts on trust, engagement, and a sense of presence. This work aims to advance the study of artificial social interactions, and guide industry practice. Edify is a platform that combines gaming tech, virtual reality and user generated content to enable accessible, immersive and engaging educational experiences. Educators can teach in virtual environments and deliver immersive lessons remotely - while participants interact and collaborate. Research in the use of avatars in teaching, specifically, immersive education, is sparse. Understanding the challenges from previous research on embodiment and avatars research can help us understand how the benefits of immersive teaching can be enhanced. With the expertise from cutting edge immersive technology (Edify.ac), computer science and psychology (University of Glasgow) we can begin connecting these individual research strands. | Missing/Incomplete | 0business_rnd_innovation
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gen_a067e81f94e7301d2a9a76e1f51989f7 | Standard Approach to atMP tissue ColLEction (Sample) | Innovate UK | The Christie NHS Foundation Trust | HRCS22_21930 | Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details. | Missing/Incomplete | 6project_grants_public
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gen_5ed3dbb055d9e1d3731a6d21057fdd4f | How might the Xploro application improve the understanding and acceptance of sedation and anaesthesia for child patients and their families | Innovate UK | Xploro Limited | HRCS22_22091 | Pain associated with procedures can be mitigated but sometimes not eliminated. Children who require repetitive procedures as part of diagnostic or therapeutic interventions may develop peri-procedural fear and anxiety. Mitigating these adverse psychological responses requires developing coping skills that build upon patient and parental preparation. So, what does this mean to the young child that has to undergo a bone marrow biopsy, lumbar puncture as well as MRI of brain and spine to make a diagnosis of acute leukemia? Informing the child what the procedures entail, why they are necessary and what parts may be painful are imperative for assent. The important question is how can we decrease the pre-procedural fear or anxiety for the patient, and is there any potential impact in lessening the stress for parents and siblings? Through the unique use of an artificially intelligent Avatar Guide, 3D augmented reality models and a series of games the Xploro platform has already been shown to reduce anxiety for children undergoing radiological procedures, having blood tests and attending an outpatient's department. We now want to build on that success and collaborate with a leading international institution to examine whether new content has the potential to reduce pre-procedural anxiety for children undergoing sedation and anaesthesia. In this project Xploro will work with the clinical, commercial and user experience teams at University Hospitals, Cleveland to define a scope of work for developing and commercialising a game-based intervention preparing children and their families for the end-to-end journey of a procedural sedation encounter. | Missing/Incomplete | 0business_rnd_innovation
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gen_8c5e06fd4df1aee454607c2da5f68582 | AGATA: Precision Spectroscopy of Exotic Nuclei | Science and Technology Facilities Council | University of York | HRCS22_22488 | The structure of the atomic nuclei, i.e. how protons and neutrons arrange themselves and how they interact among each other to form complex nuclei, has a decisive impact on everyday life, from the very existence of carbon-based life on Earth to critical nuclear physics applications such as carbon dating. Our understanding of nuclear structure is still elusive and relies on sophisticated experiments that deliver critical observables of atomic nuclei. For example, our experiments use particle accelerators that collide nuclei travelling at up to 50% the speed of light on stationary material to induce nuclear reactions. Typically, fewer than one in a million reactions will create the nucleus under study and the states of interest live, typically for less than a billionth of a second. To detect such rare events and measure the properties we are after, we need to develop very sensitive instruments. This project supports the development of one of the most sensitive "microscopes", the AGATA spectrometer, for gamma rays that are emitted during the accelerator-induced nuclear reactions. These gamma rays carry critical information about what happened during the (violent) nuclear reaction. By studying the energy and direction of the gamma rays, we can extract the properties of the atomic nuclei that were involved in the collisions. Our results will help address critical questions in modern nuclear science. AGATA constitutes a dramatic advance in gamma-ray detection that has wide ranging applications in medical imaging, astrophysics, nuclear safeguards and radioactive-waste monitoring, as well as introducing new detection capability for nuclear-structure studies. Indeed, the instrumentation and technical advances driven by this work and the knowledge gained by those involved will be important in a wide range of applications, such as in medicine and industry. For example, in medical imaging, reconstruction of the gamma-ray energies and determination of their direction will result in vastly improved images. Another beneficiary will be in nuclear safeguards where one of the big problems is the identification of the range of isotopes in waste and the determination of their quantities. | Missing/Incomplete | 7research_infrastructure
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gen_0fb63fcc1ffdfb6fca04f0a56f1b6689 | DARA Big Data: 2019 Extension | Science and Technology Facilities Council | University of Manchester | HRCS22_22490 | DARA Big Data is building research capacity around Big Data and the fourth industrial revolution in Southern Africa through high quality education and research. These high-value technical skills are applicable not only to scientific research but also to the space sector, as well as numerous other industrial and commercial sectors where diversification, technological upgrading and innovation are key drivers of economic growth. Moreover the key research areas of DARA Big Data are well-aligned both with the UN Global Goals and the African Union 2063 vision for advanced technologies, in order to improve welfare at the same time as targeting economic growth. DARA Big Data provides bursaries for students from the partner countries of the African VLBI Network (AVN) - Botswana, Ghana, Kenya, Madagascar, Mauritius, Mozambique, Namibia and Zambia - to study for MSc(R) and PhD degrees at universities in South Africa and the UK. These degrees are in the three data intensive DARA Big Data focus areas of astrophysics (Astro Big Data), health data (Health Big Data) and sustainable agriculture (Agri Big Data). In addition to providing studentship bursaries, DARA Big Data also works in partnership with South African SKA project (SKA-SA), now incorporated into the South African Radio Astronomy Observatory (SARAO), on the broader Big Data Africa program. Big Data Africa provides training workshops in machine learning, big data techniques and data intensive methodologies across the three DARA Big Data focus areas. These workshops and training courses take place in South Africa and other AVN countries, and are open to students from across the AVN country network who are currently in the honours year of their undergraduate degree or who are already pursuing a masters or PhD level research degree in those countries. | Missing/Incomplete | 6project_grants_public
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gen_2d460e53b3978dda6a48d73053cb01cd | Development of advanced laserwire accelerator diagnostics and laser controlled particle beams | Science and Technology Facilities Council | Royal Holloway University of London | HRCS22_22493 | The proposed research will implement a laserwire at the new FETS accelerator at RAL, to measure the transverse emittance of the high power 3 MeV hydrogen ion beam. The technique will be developed to monitor the longitudinal bunch structure via ultrafast laser pulses. We propose new concepts for laser controlled particle beams, based on the photo-detachment of accelerated ions and the extraction of an adjustable intensity, steerable proton beam, suitable for medical and accelerator applications. | Enterics, Diagnostics, Genomics & Epidemiology / Missing/Incomplete | 6project_grants_public
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gen_bcd592af5b435e64cd775b33867be6cb | Gates Foundatoin | Language and Learning Foundation | INV-023227 | to support the development of public goods for the teaching and learning of foundational literacy and numeracy | Maternal, Newborn, Child Nutrition and Health / Global Growth & Opportunity | 5out_of_scope
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gen_ed0f8d2af33bde721d1c4f4fe34b9c34 | Gates Foundatoin | Columbia University | INV-023818 | to provide for general operating support | Polio / Global Policy and Advocacy | 2institutional_funding
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gen_016aedac7ffe6bca6d34945b957e39d4 | Gates Foundatoin | School for Ethics and Global Leadership | INV-023952 | to provide general operating support | Pneumonia & Pandemic Preparedness / Executive | 5out_of_scope
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gen_b0f840e39f4aafe6ae61879de4a7939a | Gates Foundatoin | Pathfinder International | INV-025157 | to provide technical support to the Senegal Covid-19 Task Force and to establish an Innovation Investment Facility, a facility that is entirely dedicated to Covid 19-related innovative schemes with a focus on women's businesses | Community Engagement Grantmaking / Global Development | 4other_research_funding
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gen_d464749c96e98a273794a457492ade6d | Gates Foundatoin | Manus Bio Inc. | INV-026772 | To develop a bacterial strain that produces artemisinin | Community Engagement Grantmaking / Global Health | 0business_rnd_innovation
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gen_39ca68609414b57e8e61183517b86be8 | Gates Foundatoin | Connected DMV | INV-028551 | to identify and help launch strategic projects needed to advance pandemic avoidance and preparedness | Empower Women and Girls / Global Health | 6project_grants_public
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gen_8d4d18df568a048de83db9900676f78c | Gates Foundatoin | Johns Hopkins University | INV-028791 | to provide technical support to the government of Pakistan and country partners in the domains of nutrition science, implementation research, and program design. | K-12 Education / Gender Equality | 6project_grants_public
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gen_696845cc457fd8cc5995b9764e36a92f | Gates Foundatoin | Zearn | INV-028841 | to support development of novel resources to accelerate student mastery of algebra | Agricultural Development / U.S. Program | 5out_of_scope
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gen_46396fcd879dd8311c19e6cf2cf49771 | Gates Foundatoin | Wits Health Consortium (Pty) Ltd | INV-030196 | to enable African regulators in ensuring the safety of medical products being used by their populations | Public Awareness and Analysis / Global Health | 6project_grants_public
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gen_e6c2d06bf5973c9a6d761630b9b9a12c | Gates Foundatoin | Howard University Public Charter Middle School For Mathematics & Science | INV-028839 | to support development of novel resources to accelerate student mastery of algebra | K-12 Education / U.S. Program | 5out_of_scope
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gen_dac9d78b3787330b9b9c65743fbe2247 | Gates Foundatoin | Transforming Rural India Foundation | INV-019063 | to provide data and analysis in integrated, digitally-enabled farmer-facing services in Bihar, India | Empower Women and Girls|Global Health and Development Public Awareness and Analysis / Global Growth & Opportunity | 5out_of_scope
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gen_5484f2f50dc38af37246ce7a61cbdedd | Gates Foundatoin | European Centre for Development Policy Management | INV-024923 | to promote a better informed partnership between Europe and Africa by making a compelling case for substantial levels of European ODA directed towards poverty reduction and human development in SSA | Research and Learning Opportunities / Global Policy and Advocacy | 5out_of_scope
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gen_d4dc46d042d5589acaa23a9c67b4e24c | Gates Foundatoin | United Nations Capital Development Fund | INV-025619 | to scale up innovations leading to large impact in India and extend reach to regions beyond India | Polio / Global Development | 4other_research_funding
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gen_35be53d174505f3fc78eed811664b87e | Gates Foundatoin | Nutcracker Therapeutics, Inc | INV-025870 | to assess the potential of a novel mRNA manufacturing platform for future pandemic responses | Polio / Global Health | 0business_rnd_innovation
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gen_0f6c2fc109c8d57c19fa604cfc3ae05d | Gates Foundatoin | Community Design Partners | INV-026747 | to create and disseminate a resource to support continuous improvement teams in schools to begin and deepen partnerships with students | Public Awareness and Analysis / U.S. Program | 5out_of_scope
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