id
stringlengths 36
36
| title
stringlengths 0
391
| funder
stringclasses 64
values | beneficiary
stringlengths 3
1.44k
| source_id
stringlengths 0
41
| abstract
stringlengths 6
4.76k
| funding_scheme
stringclasses 403
values | label
class label 8
classes |
|---|---|---|---|---|---|---|---|
gen_db3ddc573baeac0c0b08e9bc099b53ef | Computational Techniques for Calculating Gravitational Radiation Reaction for LISA | Irish Research Council | University College Dublin | Not available | Early Career / EMBARK | 6project_grants_public
|
|
gen_bdf4d1522af73dc31a5a31a803445736 | Exploring the relationship between cell culture duration and the populations of host cell proteins and the resulting impact on upstream and downstream processing of monoclonal antibodies. | Irish Research Council | University of Limerick | Not available | Early Career / Enterprise Partnership Scheme (Postgraduate) | 6project_grants_public
|
|
gen_eb4af4ad49d73ce5bc1feeb4f4b9e75e | Study on the Proteolytic and Peptideolytic Release of Bioactive Peptides from Food Proteins | Irish Research Council | University of Limerick | Not available | Early Career / EMBARK | 6project_grants_public
|
|
gen_b9b3d7df8af4827ec646d1715f532a2f | Cross-sectoral partnerships in the performing arts: New models of strategy for non-profits in times of crisis from the business sector | Irish Research Council | University of Limerick | Not available | Early Career / Employment-Based Programme | 6project_grants_public
|
|
gen_d8ee2c868fecf5844f2cb89cbecd2c26 | A Novel Cellular Architecture for Fault Repair in Virtex FPGA Designs | Irish Research Council | University of Galway | Not available | Early Career / EMBARK | 6project_grants_public
|
|
gen_c3205ecf8306923ee7ec41f9c0e8f0f2 | Identification of Biomarkers for the Diagnosis, Management and Follow-up of Women with Gestational Trophoblastic Disease | Irish Research Council | University College Cork | Not available | Early Career / Employment-Based Programme | 6project_grants_public
|
|
gen_10bde8b4153a9e8ac08712f5ffdda8e0 | Synthesis and Conformational Analysis of Macromolecules containing Two Isoxazolidine Rings | Irish Research Council | Maynooth University | Not available | Early Career / EMBARK | 6project_grants_public
|
|
gen_e77a0de03b8afda6410ac23e80ab3abe | Population dynamics, habitat use, philopatry and feeding behaviour of the Red Squirrel (Sciurus vulgaris) | Irish Research Council | University College Cork | Not available | Early Career / Enterprise Partnership Scheme (Postdoctoral) | 1fellowships_scholarships
|
|
gen_f527ac8a0b348a211e2617e80873f35a | Mechanisms of Signal Integration on Chromatin by DNA Damage Response Proteins | Irish Research Council | University of Galway | Not available | Early Career / EMBARK | 6project_grants_public
|
|
gen_0822efa3715ad3344fcff3108740b6a6 | Mapping Brain and Behaviour in the Experimental Induction and Removal of Implicit Prejudice using a High-Density EEG Array and Source Localisation Analyses | Irish Research Council | Maynooth University | Not available | Early Career / EMBARK | 6project_grants_public
|
|
gen_1a452e9d356620bb845342bc60ff40e6 | Scalable Reasoning for Enhanced Query Answering over Web Knowledge Bases | Irish Research Council | University of Galway | Not available | Early Career / EMBARK | 6project_grants_public
|
|
gen_550fdd888eb1b37274bc783cd6087e37 | A Digitally Assisted Analog Front End for Reflectance Spectrophotometry in Biomedical Applications | Irish Research Council | University of Limerick | Not available | Early Career / Employment-Based Programme | 6project_grants_public
|
|
gen_a73cbb3c3b07bb51e7339d9bd01fae47 | Chemical signaling in the tritrophic potato-PCN-Rhizobacteria interaction | Irish Research Council | University College Cork | Not available | Early Career / EMBARK | 6project_grants_public
|
|
gen_ae1b922db34ab4b0cc745782d90b3de8 | Nucleolar Protein Dynamics in Meiosis | Irish Research Council | University College Dublin | Not available | Early Career / EMBARK | 6project_grants_public
|
|
gen_1e55daba5e8f483afd6b2198359a7aa1 | Machine Learning and Biometrics for In-Home Health Care Monitoring | Irish Research Council | Maynooth University | Not available | Early Career / EMBARK | 6project_grants_public
|
|
gen_60f68408f258aec997ba0f186a4eeb16 | Vascular Dysfunction in a Rat Model of Sleep Apnoea | Irish Research Council | University College Dublin | Not available | Early Career / EMBARK | 6project_grants_public
|
|
gen_360e232dd4c8934a7c5c074d0801c10e | A Nutritional Systems Biology Approach to Identifying Nutrient-Sensitive Biomarkers associated with Type 2 Diabetes Mellitus, Atherosclerosis and the Metabolic Effects of Fatty Acid Interventions | Irish Research Council | University College Dublin | Not available | Early Career / EMBARK | 6project_grants_public
|
|
gen_3d51814a2fd049d8aff3b6c817eed608 | Unsalaried health workers in Sierra Leone: What impact does their unpaid status have on their lives and on the health services they deliver to populations? | Irish Research Council | Dublin City University | Not available | Early Career / SFI-IRC Pathway Programme | 1fellowships_scholarships
|
|
gen_d09b06d310c3df8c5a55e100c3578699 | Financing the Sustainable Development Goals: Enhancing the role of Law in the Governance of Blended Finance | Irish Research Council | University College Dublin | Not available | Early Career / CAROLINE | 6project_grants_public
|
|
gen_ff8c9190fa6b3386939a878f7039ac1b | Towards a two-terminal nano-electronics via one-dimensional nanowires. | Irish Research Council | Trinity College Dublin | Not available | Early Career / Enterprise Partnership Scheme (Postdoctoral) | 1fellowships_scholarships
|
|
gen_fb4b7daad73da9ae91c58563cc47a797 | Electromagnetic Analysis of an Antenna Array for SPICA: A Future Infrared Astronomical Observatory Proposed by the European Space Agency and Japan | Irish Research Council | Maynooth University | Not available | Early Career / EMBARK | 6project_grants_public
|
|
gen_aef10332666f4ace8ba2398ce471fbf9 | Novel Antimicrobials and their Role in Disease Prevention | Irish Research Council | Athlone Institute of Technology | Not available | Early Career / EMBARK | 1fellowships_scholarships
|
|
gen_289efa76a66c7e9edd2d9847139b60bc | Spin Polarisation Dynamics for Antiproton And Proton Collisions | Irish Research Council | Trinity College Dublin | Not available | Early Career / EMBARK | 6project_grants_public
|
|
gen_e04b295658e1fffea18513d92a5a2763 | Reformulating Mental Health Law and Policy in Ireland in Light of the UN Convention on the Rights of Persons with Disabilities | Irish Research Council | University of Galway | Not available | Early Career / Employment-Based Programme | 1fellowships_scholarships
|
|
gen_528cf798f57dc4ff3a85699478e1d4f0 | Biochemical and Structural Analysis of Cell Envelope Proteases Targeting Host Immune Factors | Irish Research Council | University of Limerick | Not available | Early Career / EMBARK | 6project_grants_public
|
|
gen_e3fb849c5bbcaa984e1bd0c08ac5d1eb | A Dynamic Model of Irish Carbon Sinks and Flows as an Aid to Fulfilling our EU Greenhouse Gas Reduction Obligations | Irish Research Council | Dublin City University | Not available | Early Career / EMBARK | 6project_grants_public
|
|
gen_9f2839c618d43a7f7ccb10cc2824d773 | Development of Advanced Analysis and Testing Methodologies for the Design of a Novel Device for the Fixation of Proximal Humerus Fractures | Irish Research Council | University of Galway | Not available | Early Career / EMBARK | 6project_grants_public
|
|
gen_31fc89a089f561f8a1b178f87c5dbcb8 | Improved Computational Fluid Dynamic (CFD) Modelling for Jet Noise Applications | Irish Research Council | Trinity College Dublin | Not available | Early Career / EMBARK | 6project_grants_public
|
|
gen_227c02a04c7c99f1b9b4698d5a8e2731 | Oral Drug Delivery Product Development and Optimisation through State of the Art Spectoscopy Techniques | Irish Research Council | Technological University Dublin | Not available | Early Career / Employment-Based Programme | 6project_grants_public
|
|
gen_35f84eb1606ada0a5e21d217bd5281ee | Single Stage Deployment of Multiple Medical Devices using Perception Enhancement | Irish Research Council | University of Limerick | Not available | Early Career / EMBARK | 6project_grants_public
|
|
gen_582cb8376da12a80c8bd1229a8f0aca4 | Gaia bright stars data processing and analysis | Irish Research Council | University College Dublin | Not available | Early Career / European Space Agency Traineeship Scheme | 1fellowships_scholarships
|
|
gen_6f66394c660e6a0af6953bed8f9897e6 | A Knowledge Based Approach to Calculating Turbine Availability for Large Sets of Windfarm Data | Irish Research Council | University College Cork | Not available | Early Career / Employment-Based Programme | 6project_grants_public
|
|
gen_0e98a545dc4077d6fd5e10bb6010e56b | Solid-State and Micromeritic Characterisation of Spray Dried Nano/Microparticles | Irish Research Council | Trinity College Dublin | Not available | Early Career / EMBARK | 6project_grants_public
|
|
gen_c1a623ecd51cac2480d7cf6d8d68dd4a | The lives, experiences and outcomes of young people who are detained at Oberstown Children Detention Campus - A Participatory Study | Irish Research Council | University College Cork | Not available | Early Career / Employment-Based Programme | 6project_grants_public
|
|
gen_db7b20f1dc177473b09acb737c82ad5e | Achiral Catalysts with Chiral Co-Factors: A New Twist on Organocatalysis | Irish Research Council | Maynooth University | Not available | Early Career / EMBARK | 6project_grants_public
|
|
gen_54d74032d509dc1fcedf0ec4ffd08543 | Investigation of 5-Lipoxygenase Inhibitors in Obesity-Driven Oesophageal Adenocarcinoma: A Focus on the Anti-Angiogenic and Vessel Stability Effects of a Novel Class of Small Molecule Inhibitors | Irish Research Council | Trinity College Dublin | Not available | Early Career / EMBARK | 6project_grants_public
|
|
gen_4dd83ddbb001576bf9c4cdd9e79c9d39 | Exploring Dynamics on Complex Networks | Irish Research Council | University of Limerick | Not available | Early Career / INSPIRE | 6project_grants_public
|
|
gen_ebdddf15730c5e04e932a386eae7ae31 | Using an Ecological Footprint to Operate and Maintain a Short-Term, Sustainable, Self-Regulating and Community-Based Environmental Management Programme | Irish Research Council | University of Limerick | Not available | Early Career / EMBARK | 6project_grants_public
|
|
gen_2ed108161853c46a9a3c2201ff0657d4 | Development of Novel CoBlast Coatings | Irish Research Council | University College Dublin | Not available | Early Career / Employment-Based Programme | 6project_grants_public
|
|
gen_4b9a2b5fdc2bab83a943531e4f2d640c | Investigations of experimental jet lag in the horse to identify novel molecular markers of circadian resynchronisation and evaluate a potential prophylactic light treatment programme. | Irish Research Council | University College Dublin | Not available | Early Career / Enterprise Partnership Scheme (Postgraduate) | 6project_grants_public
|
|
gen_0158305c9260ede1517181ca1f16ead5 | Extraction & Characterisation of Pyrrolizidine Alkaloids (PA's) from Senecio Jacobea (Ragwort) with Application to the Food and Health Industry | Irish Research Council | Limerick Institute of Technology | Not available | Early Career / EMBARK | 6project_grants_public
|
|
gen_9010dbe3a37b8bc129f06e5a410884ad | Establishing Minimum Income Standards for Irish Households | Irish Research Council | Unknown | Not available | Principal Investigator-led / Research Development Initiative | 6project_grants_public
|
|
gen_d67475906d9247e7840d8b7c74089352 | Investigation of Nano-Electrochemical Processes of Bioanalytical Importance | Irish Research Council | University College Cork | Not available | Early Career / EMBARK | 6project_grants_public
|
|
gen_9dd16aef89f6d9a084ea18f06a54a7ed | Role of ADAM10 Proteinase in Breast Cancer | Irish Research Council | University College Dublin | Not available | Early Career / EMBARK | 6project_grants_public
|
|
gen_492de993f5b5c9608cd472c8394c3a08 | An Investigation of Occupational Noise Exposure and Reduction in Nightclubs | Irish Research Council | Technological University Dublin | Not available | Early Career / EMBARK | 6project_grants_public
|
|
gen_08f548f1f5d4f4ac59c7e12b363c8e3c | En Sund Renoveringspraksis: Passive indeklimaløsninger i den historiske boligarkitektur | Independent Research Fund Denmark | Arkitektskolen Aarhus | 1060-00028A | Forskningsprojektets formål er at bidrage til en bæredygtig renoveringspraksis, som tager udgangspunkt i det sunde indeklima og byggeskikken i det eksisterende boligbyggeri. I dag opholder danskerne sig 80-90% af tiden indendørs, og over halvdelen af den tid tilbringes i hjemmet. Boligens indeklima har derfor stor betydning for vores sundhed og velbefindende. I nutidig renoveringspraksis er boligernes energiforbrug et stort fokusområde, og der findes et betydeligt potentiale for energieffektivisering i det eksisterende boligbyggeri. Forskning viser imidlertid, at en markant reducering af energiforbruget i boligerne vil give udfordringer på indeklimaområdet. Derfor er det essentielt, at der i kommende renoveringer fokuseres særligt på indeklimaet for at opnå et sundere og dermed mere bæredygtigt resultat. I modsætning til den gængse praksis, vil jeg med dette forskningsprojekt undersøge, hvorledes man med inspiration fra historiske boligtyper kan indarbejde et godt indeklima i kommende renoveringer. For at skabe et videngrundlag til fremtidig praksis og forskning, vil jeg undersøge, hvordan indeklimaet historisk er blevet indtænkt i boligarkitekturen samt identificere arkitektoniske elementer, som fremmer et godt indeklima - passive indeklimaløsninger. Forskningsprojektet udføres gennem en kombination af teoretiske og empiriske studier og munder ud i en række anbefalinger til renovering, som tager afsæt i boligens arkitektoniske kvaliteter og passive indeklimaløsninger. | Research Education (PhD) / Forskeruddannelse uden for universiteterne / grant | 6project_grants_public
|
gen_9a9015211d6ac11ab90f6c310f855c24 | Design Thinking Research Symposium 11 | Independent Research Fund Denmark | Copenhagen Business School Handelshøjskolen | 6107-00296A | Design er på vej til at indtage en prominent rolle i måden vi tænker på. Design dækker over langt mere end produktdesign, formgivning og styling. I dag bruges design både som metode og redskab, strategisk og løsningsorienteret. Design dækker over en række processer og discipliner, der anvendes i virksomheder, organisationer, styrelser og på statslige niveauer for at befordre alt fra nye forretningsområder, bedre services, velfærd og økonomisk vækst. Konferencen Design Thinking Research Symposium 11 (DTRS11) udforsker de metoder og tilgange til idéudvikling, innovation og kreativitet, som designere anvender i deres daglige arbejde. Formålet for DTRS11 er, at udvikle en dybere forståelse for hvordan designere, teams, virksomheder og organisationer skaber nye og innovative produkter og services. DTRS11 er den 11. konference i Design Thinking Research Symposium serien, der siden 1991 har dannet rammen omkring et internationalt tværfagligt forum, hvor forskere mødes for at præsentere, samle og videreudvikle den nyeste og mest banebrydende forskning inden for Design Thinking og studier af design. Konferencen afholdes i november 2016 og markerer samtidigt 25års jubilæet for Design Thinking Research Symposium serien. Emeritus professor Nigel Cross, en af de mest indflydelsesrige forskere inden for designfeltet og forfatter til flere klassiske værker bl.a. ’Design Thinking: Understanding how Designers Think and Work’, er inviteret som keynote-speaker. | Research Projects (Max 10 MDKK) / Øvrige virkemidler / grant | 3networking_collaborative
|
gen_827e1accce7d73c440a6a04a8f4ff514 | The Role of Islam in Modern Muslim State-Making | Carlsberg Foundation | University of Southern Denmark | CF22-0016 | Not available | Research / Conferences / Award | 6project_grants_public
|
gen_9a3277a7a6ddb7616a80e0a06584dc50 | Building sustainable societies with intergenerationally just policies? A multidimensional analysis for Denmark and 31 OECD countries, 1995-2015 | Carlsberg Foundation | University of Southern Denmark | CF20-0237 | What? My project focuses on how we can build more sustainable societies with more intergenerationally just policies. The aim is theoretically informed but empirical and rigorously policy-oriented: to measure and compare intergenerational justice in policy practice across 32 countries: Denmark, its Nordic neighbors, the EU's big three economies (Germany, France and Italy), and the OECD world. Contextually, the project will touch on important contemporary questions of policy sustainability, societal resilience and good governance, related to SDGs 1, 4, 10, 13, and 16. Why? The UN's 17 Sustainable Development Goals have increased the global salience of sustainability in public policy. Rising debt levels and inequalities, population aging and the climate crisis have strengthened perceptions that the long-term wellbeing of especially younger and future generations is under threat. However, efforts to measure the intergenerational justice component of sustainability empirically have lagged behind both political and academic debates. How can we improve policies when we only have very incomplete command of the state of affairs in policy practice? This project aims to provide comparative insights into this key question of governance. How? I will delve deep into the measurement of intergenerational justice in the public policy models of many advanced democracies, with multidimensional measures and recent data over a twenty-year period. The unit of analysis will be countries. The multi-indicator empirical analysis will be complemented with in-depth case studies on Denmark, its three fellow Nordic countries, and the EU s three biggest economies, Germany, France, and Italy. The main observational period will be 1995 to 2015, with individual time series data extending beyond this period. | Research / Monograph Fellowships / Award | 6project_grants_public
|
gen_ebc2bc1840e7359bd1eafd8736feb6b7 | Kåre og Emil - Naturvidenskabsformidling på YouTube | Novo Nordisk Foundation | Nielsenformidling | NNF23OC0084910 | Not available | Research Dissemination / Projects / Award | 6project_grants_public
|
gen_7cd5e3d861fcd54cb3bc6c331509ab45 | NAVIGATE – Improving survival in vulnerable lung cancer patients through individual support: a multicenter randomized controlled trial | Novo Nordisk Foundation | Kræftens Bekæmpelse | NNF20OC0064570 | Research shows that there are social differences in lung cancer prognosis, which can be explained by late diagnosis, poor physical condition, comorbidity, and low completion of treatment. In the NAVIGATE study, we wish address the social differences in lung cancer survival through a new supportive program where nurse navigators will guide and support vulnerable lung cancer patients before, during and after their cancer treatment. The nurse-led program holds three components: 1) support in completion of treatment and in self-managing symptoms and referral to health services 2) regular reporting of physical and psychological symptoms and 3) exercise training and support in health behavior change. We will evaluate the effect of the program on overall survival, treatment completion, symptom burden and health related quality of life in a randomized controlled trial inviting all lung cancer departments in Denmark. | Postdoc / Fellowships / Award | 6project_grants_public
|
gen_f32eae0bce53a30b364b27b8cdf224a9 | Using Big Data sources for the consistent estimation of next-generation route choice models | Independent Research Fund Denmark | Danmarks Tekniske Universitet | 6111-00493A | Trafikmodeller benyttes til vurdering af potentielle infrastrukturprojekter. Idet sådanne projekter er meget dyre og påvirker mange rejsende, er det essentielt at beslutningsgrundlaget er så godt som muligt. Modellerne skal derfor formå at repræsentere det virkelige transportsystem nøjagtigt. Dette er imidlertid ikke en triviel opgave, idet systemet består af rejsende som foretager rationelle eller irrationelle valg i et komplekst vejnet under konstant forandring. Rutevalget udgør en stor og vigtig komponent af enhver trafikmodel, men mange af nutidens rutevalgsmodeller er teoretisk inkonsistente. Desuden er de ofte kalibreret manuelt, baseret på data genereret af spørgeskemaundersøgelser med urealistiske hypotetiske valgsituationer. Der er for nylig blevet udviklet en teoretisk konsistent rutevalgsmodel, men der foreligger endnu ikke metoder til estimation af denne. Projektets formål er at udvikle metoder til konsistent estimation af den nye rutevalgsmodel, der udnytter nye Big Data kilder (f.eks. GPS data). Sådanne datakilder er attaktive, idet de indeholder information om faktisk foretagede valg fremfor valg i hypotetiske situationer. Desuden indeholder de ofte mange observationer. Projektet vil implementere metoden i software, og anvende denne i kombination med GPS data til at estimere Landstrafikmodellen. Dette vil sikre et bedre beslutningsgrundlag for fremtidige infrastrukturprojekter. Landstrafikmodellen anvendes bl.a. af Transportministeriet til projektvurdering. | Postdoc / DFF-Individuel Postdoc / fellowship | 1fellowships_scholarships
|
gen_c29dc55b73002bf4ba63776cb14fcc88 | Mindset matters: Kan ændret mindset om fysisk aktivitet i arbejde forbedre rengøringsassistenters sundhed? Et kluster-randomiseret lodtrækningsstudie | Independent Research Fund Denmark | Det Nationale Forskningscenter for Arbejdsmiljø | 3127-00011A | Mange voksne med korte uddannelser og manuelt arbejde har store sundhedsudfordringer, men mangler ressourcerne til at foretage varige livsstilændringer på egen hånd. Dette har store udfordringer i forhold til arbejdskraftsmangel, sygefravær og social ulighed i sundhed. Hvor gavnligt ville det ikke være, hvis denne medarbejdergruppe kunne blive sundere og i bedre form af den fysiske aktivitet de allerede udfører som en del af deres arbejde? Et lodtrækningsstudie fra Harvard Universitet viste, at ved at ændre rengøringsassistenters mindset fra at fysisk aktivitet i arbejde er nedslidende, til at være sundhedsfremmende, så opnåede de betydelige forbedringer i sundhed, herunder reduktion i blodtryk, fedtprocent og livvidde. Vi vil i et kluster-randomiseret lodtrækningsstudie afprøve om man ved at ændre rengøringsassistenters mindset om fysisk aktivitet i arbejde – fra at være nedslidende til at være sundhedsfremmende – forbedrer deres sundhed og fysisk form. Hvis et positivt mindset om fysisk aktivitet i arbejde giver en reel forbedret sundhed for kortuddannede med manuelt arbejde, så kan det bidrage til at løse store samfundsudfordringer, såsom arbejdskraftsmangel og social ulighed i sundhed. | Research Education (PhD) / Forskeruddannelse uden for universiteterne / grant | 6project_grants_public
|
gen_0067b1fca57292420ecc92c286fea07a | Behavioural modelling of public transport passengers using big data sources | Independent Research Fund Denmark | Danmarks Tekniske Universitet | 0130-00012A | I dag baseres analyser af de kollektive rejsendes præferencer primært på ad hoc analyser, der er dyre at foretage og oftest kun indeholder meget få respondenter, samt den nationale Transportvaneundersøgelse, der på trods af repræsentativitet og relativt stor stikprøve dog baserer sig på relativt få kollektive rejsende. Samtidig har vi i Danmark en enorm u-udnyttet kilde af information om passagerernes rejser og deres præferencer, nemlig Rejsekort, der i 2018 anvendtes til over 100 mio. kollektive ture. Rejsekort indeholder detaljeret information om passagerers rejsevaner indenfor det kollektive netværk, men kan ikke benyttes direkte i planlægningen grundet manglende information om hvor hele turen reelt starter og slutter, samt manglende repræsentativitet. Formålet med dette projekt er således at udvikle en metode, der kan skabe et samlet datasæt til planlægning baseret på Rejsekort, Transportvaneundersøgelsen samt operationelle data fra det kollektive netværk. Dette kræver anvendelse af datafusions-teknikker baseret på avancerede spatio-temporale statistiske analyser. Med et sådant datasæt vil det være muligt at skabe et bedre grundlag for analyser af de rejsendes adfærd. Datasættet vil blive anvendt til at frembringe ny viden om, hvad der gør kollektiv trafik mere attraktivt set fra passagerernes synsvinkel. Dermed kan den store u-udnyttede datakilde komme til gavn – og i sidste ende sørge for bedre kollektiv trafik til gavn for passagererne. | Postdoc / DFF-International Postdoc / fellowship | 6project_grants_public
|
gen_1e5e056f4f6379cf489de6387a835933 | Music, Performing Arts and Artists in the North: The French and Italian Diasporas (1600-1900) | Carlsberg Foundation | Det nationalhistoriske Museum, Frederiskborg Slot and Château de Versailles | CF18-0357 | Not available | Research / Conferences / Award | 6project_grants_public
|
gen_1c42acb451a815f10f047263d32c3a0e | Dominican Culture, Dominican Theology: The Order of Preachers and Its Spheres of Action, 1215-c. 1600 | Carlsberg Foundation | University of Copenhagen | CF19-0794 | In the high Middle Ages, a novel concept of religious community overran the occidental world: the Dominican Order. Unlike earlier religious orders who confined monks to the purview of praying the liturgy and living a life of contemplative seclusion, the Dominicans focused on engaging with the broad community beyond the convent walls. The result was a hitherto unseen interpenetration of a religious order into the intellectual as well as cultural realities surrounding it. This conference aims at generating new insights into the Dominican importance by stimulating interdisciplinary debate on Dominican culture and Dominican theological thought as two aspects of the same medieval and early modern reality. What? Why? How? | Research / Conferences / Award | 3networking_collaborative
|
gen_0cff035f7879ecc453cedce4d84f1ebb | Translational Investigator Training Programme | Novo Nordisk Foundation | University of Copenhagen | NNF17SA0030176 | Not available | Research / Programmes and collaborations / Award | 6project_grants_public
|
gen_6b961deedbd9d8c4d3761a27f5285281 | Clinical Validation of Novel Sports and Diabetes Related Analytes Offer New Wearable Diagnostics Solutions | The Finnish Research Impact Foundation | Oulu University | The Body Mass Index (BMI) has increased and today over 50% are considered obese. High BMI increases risks for diabetes and metabolic syndrome. The reasons are that calorie intake exceeds consumption, and ageing is associated muscle reduction thus reduced energy consumption. Physical exercise affecs positively these conditions includingthe brain by increasing cardiovascular performance and brain gas exchange. Two challenges will be targeted between the academic and Polar company: 1) How to motivate laymen and diabetic people of at high risk for this for physical exercise and 2) How to establish novel rewarding biofeedback biosensor loops that will illustrate clearly, rapidly and in exiting ways the positive impact of the physical and associated mental exercise to the performer. | Tandem Industry Academia (2020) | 6project_grants_public
|
|
gen_4849f29c15a1016e78def1f49647cd0c | Breathing of biosphere – Industrialization of easy-to-use carbon dioxide exchange measurements | The Finnish Research Impact Foundation | University of Helsinki/INAR | An improved understanding of carbon sinks and sources of various ecosystems is one of the priorities for scientists devoted to study interactions of the biosphere and atmosphere. They can be measured by so called flux towers. Flux measurements seem to start to play more important role in assessing carbon sinks of different land-use types also outside academia. Vaisala and University of Helsinki aim to lever the best industrial and academic competences, couple them with real-life users from industrial producers to research, in operationalizing a flux tower that is inexpensive, low-powered, easy-to-use and virtually maintenance free. With a tower, which compromises between accuracy, reliability and price, we hope to revolutionize the carbon flux measurement market. | Tandem Industry Academia (2020) | 6project_grants_public
|
|
gen_3ced32cf3b17847bd06bec805c11cf0c | Multiplying In Africa European Global Navigation Initiatives Fostering Interlaced Cooperation | European Commission | SAPHYRION SAGL | CORDIS-641498 | MAGNIFIC project aims to enable the development of EGNSS applications through international cooperation. MAGNIFIC proposes to demonstrate to African Stakeholders the benefits of EGNOS and Galileo in 6 market sectors: airport surface vehicle, flight trials, Oil exploitation, Natural resources, highly secured multi-modal transport and use of secured Maritime transport. These applications have been selected based on the 6 priority applications identified in the GSA Action plan on GNSS applications The selection of Africa was done taking into account that the provision of SBAS over AFI has been considered by EU since the early phase of development of EGNOS. Particularly, countries from West Africa have been selected being those countries the ones with the highest growth foreseen for the next 5 years. Certainly, one of the key aspects of the proposed solution is the possibility of the consortium of simulating EGNOS signal thanks to Thales Alenia Space SPEED platform. Other key aspects from our solution to be highlighted are: • Full range of partners allowing networking among European SMEs, European Industry European Research Centres, African academia, African Air Navigation Stakeholders, African SMEs and African petrol companies • High innovation character, attracting the most important regional companies from Africa, who have committed officially to an active and in-kind participation in the project, multiplying the impact of MAGNIFIC. • Galileo SAR demonstrations and Oil exploitation demonstrations showing the added value of GALILEO early services. MAGNIFIC project will allow fostering application development through international cooperation, awareness of EGNOS and GALILEO applications outside Europe and ensuring networking among different kind of actors from Europe and Africa. | H2020-EU.2.1.6. / 2.1.6 LEIT - Space | 6project_grants_public
|
gen_86085572246e142bb839b5831dcfae75 | Deusto International Research School | European Commission | Lund University | CORDIS-665959 | With a proven track in PhD training (more than 1000 PhD in 50 years, 58 in 2013) the Deusto International Research School (DIRS) aims at attracting qualified international Early Stage Researchers for high quality PhD training that enhance research, complementary and transferable skills. DIRS aims are grounded in a solid structure generated around a robust and dynamic ecosystem that encourages and enables cooperation, co-creation and collegiality among 7 doctoral programmes and 24 research groups around four research foci centred on challenges identified in the EU and the Basque Smart Specialisation Strategies: i) Health and Wellbeing, ii) Human Rights, Peace and Conflict Resolution, iii) Sustainable Development and Innovation and iv) Lifelong Learning. UDEUSTO has actively and creatively procured conditions conducive to frequent dialogues between economic, cultural and social actors whose cooperation and exchanges help realise DIRS aims. These dialogues will ensure international and intersectoral mobility, including placements/internships to broaden ESR career employability tracks; cross-fertilisation of ideas and ideation of solutions to societal challenges fuelled by shared concerns and funding. 40 partners formally back DIRS project. 16 MSC PhD candidates will be selected via an open, transparent, merit-based, impartial, equitable and internationally advertised process that will take special care to avoid any form of discrimination. Upon acceptance, PhD candidates will sign an employment contract and will be hosted in an attractive environment to benefit from a shared supervision and mentoring process formally inscribed in the Doctoral Agreement and the individualized research/training development plan (Personal Career Development Plan). Full internationalisation is an essential aspect of DIRS. The COFUND scheme will strengthen the European and International dimensions of the project by consolidating the current rate of ESR (31,25% of PhD students in 2013/2014) | H2020-EU.1.3. / 1.3 Marie Skłodowska-Curie Actions (MSCA) | 1fellowships_scholarships
|
gen_3476e343f5bd90fd96ec101382580216 | Erosion and Ice Resistant cOmposite for Severe operating conditions | European Commission | MAIER, S.Coop. | CORDIS-685842 | In the wind power generation, aerospace and other industry sectors there is an emerging need to operate in the low temperature and highly erosive environments of extreme weather conditions. Such conditions mean current materials either have a very short operational lifetime or demand such significant maintenance as to render many applications either very expensive to operate or in some cases non-viable. EIROS will develop self-renewing, erosion resistant and anti-icing materials for composite aerofoils and composite structures that can be adapted by different industrial applications: wind turbine blades and aerospace wing leading edges, cryogenic tanks and automotive facia. The addition of novel multi-functional additives to the bulk resin of fibre reinforced composites will allow the achievement of these advanced functionalities. Multi-scale numerical modelling methods will be adopted to enable a materials by design approach to the development of materials with novel structural hierarchies. These are capable of operating in severe operating environments. The technologies developed in this project will provide the partners with a significant competitive advantage. The modification of thermosets resins for use in fibre composite resins represents both a chemically appropriate and highly flexible route to the development of related materials with different applications. It also builds onto existing supply chains which are represented within the partnership and provides for European materials and technological leadership and which can assess and demonstrate scalability. The partnership provides for an industry led project with four specific end users providing both market pull and commercial drive to further progress the materials technology beyond the lifetime of the project. | H2020-EU.2.1.3. / 2.1.3 LEIT - Advanced materials | 0business_rnd_innovation
|
gen_49dcff5cda507b4fd96504590a357e8f | STRengthening MARritime Technology Research Center | European Commission | INESC TEC - INSTITUTO DE ENGENHARIADE SISTEMAS E COMPUTADORES, TECNOLOGIA E CIENCIA | CORDIS-692427 | INEST TEC is strongly committed to become a center of excellence in maritime technology and, in particular, deep sea technology. It is strategically located, with fast access to deep sea, it has been steadily building up its skills, capabilities and resources, and is presently in the process of implementing an open research infrastructure, thus preparing itself to become capable of providing services and open access to the European academic and industrial communities and, thus, become a recognized European maritime research asset. This proposal thus aims at creating solid and productive links in the global field of marine science and technology between INESC TEC and established leading research European institutions, capable of enhancing the scientific and technological capacity of INESC TEC and linked institutions (as well as the capacity of partnering institutions involved in the twinning action), helping raising its staff’s research profile and its recognition as an European maritime research center of excellence. These objectives will be fulfilled through a set of measures: summer schools; winter schools; short-term scientific meetings; Long-term Staff visits; Networking meetings; Workshops; Conferences; technology transfer workshops with stakeholders; and other dissemination activities. Therefore this proposal addresses the challenges raised in the call H2020-TWINN-2015. In particular, it takes INESC TEC, a top level Portuguese institution, and places it as the pivot of a network of excellence, involving four European Partners which are international leaders in deep sea technology. By tackling the call challenge with the specific topic of deep sea technologies, STRONGMAR is aligned with several National and European priorities (“The Portuguese Strategy for Smart Specialisation” (2014); Portuguese “National Ocean Strategy” (2013); EU Commission’s Atlantic Strategy (2011), etc.) establishing a consolidation path of INESC TEC's strategy in these areas. | H2020-EU.4. / 4.0 Widening actions | 6project_grants_public
|
gen_e395c70834591e75979b3f1ac8853962 | Saving COOPerative Energy | European Commission | COOPERATIVAS AGRO-ALIMENTARIAS DE ESPANA U. DE COOP. | CORDIS-695985 | SCOoPE project will work directly with energy-intense agro-food industries to implement cross-cutting and collaborative energy management systems addressed to reduce their energy consumption, and will further spread this knowledge within technicians, businesses managers, and energy and agro-food institutions. The project SCOoPE aims at achieving the challenges of the topic EE 16-2014/2015. Regarding the use of cost-effective energy solutions, the project objective is to reduce energy consumption at a short term in a range between 10% and 15% directly in 81 businesses belonging to the agro-food target sectors of the project (namely crop drying, meat and poultry, dairy, and fruit and vegetables transformation). This reduction must be achieved without any decrease in the production capacity of the companies and maintaining correct socioeconomic and environmental conditions. In order to do that, the project will work with the uptake of specific and cross-cutting innovative technologies and techniques, which efficacy has been proven in other industrial sectors, different from agro-food sector, but that are not yet familiar to project’s target sectors. On the other hand, the project pursues larger savings in the medium term with new affordable energy solutions, specifically by developing the concept of “Collaborative Energy Management Systems”. It will take advantage of complementarities and synergies between analysed industrial sites with similar characteristics and will use them for the improvement of their joint energy efficiency. For this purpose, 6 pilot industrial clusters will be run in order to prove the improvements of total energy consumptions and its associated costs, achieved by using common procedures based on ISO 50.001 and supported by an specific software (Dashboard) developed by the project. All these experiences will be promoted to encourage target groups to reduce their energy consumption, following the example of the directly involved companies. | H2020-EU.3.3. / 3.3 Societal Challenges - Energy | 0business_rnd_innovation
|
gen_16ece7846d935d935e76ee5cb7e6b113 | Graphene-based disruptive technologies | European Commission | CENTRO DE INVESTIGACION COOPERATIVADE ENERGIAS ALTERNATIVAS FUNDACION; HORIBA JOBIN YVON S.A.S.; Queen Mary University of London; Sorbonne University; BRETON SPA; University of Augsburg; BRUNO BALDASSARI & FRATELLI SPA | CORDIS-696656 | This project is the second in the series of EC-financed parts of the Graphene Flagship. The Graphene Flagship is a 10 year research and innovation endeavour with a total project cost of 1,000,000,000 euros, funded jointly by the European Commission and member states and associated countries. The first part of the Flagship was a 30-month Collaborative Project, Coordination and Support Action (CP-CSA) under the 7th framework program (2013-2016), while this and the following parts are implemented as Core Projects under the Horizon 2020 framework. The mission of the Graphene Flagship is to take graphene and related layered materials from a state of raw potential to a point where they can revolutionise multiple industries. This will bring a new dimension to future technology – a faster, thinner, stronger, flexible, and broadband revolution. Our program will put Europe firmly at the heart of the process, with a manifold return on the EU investment, both in terms of technological innovation and economic growth. To realise this vision, we have brought together a larger European consortium with about 150 partners in 23 countries. The partners represent academia, research institutes and industries, which work closely together in 15 technical work packages and five supporting work packages covering the entire value chain from materials to components and systems. As time progresses, the centre of gravity of the Flagship moves towards applications, which is reflected in the increasing importance of the higher - system - levels of the value chain. In this first core project the main focus is on components and initial system level tasks. The first core project is divided into 4 divisions, which in turn comprise 3 to 5 work packages on related topics. A fifth, external division acts as a link to the parts of the Flagship that are funded by the member states and associated countries, or by other funding sources. This creates a collaborative framework for the entire Flagship. | H2020-EU.1.2. / 1.2 Future and Emerging Technologies (FET) | 6project_grants_public
|
gen_dfbb3218da3d4f6ce15d4128e780e7db | Human Brain Project Specific Grant Agreement 1 | European Commission | EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH; Université Lyon 1 - Claude Bernard; Linnaeus University; L'AZIENDA SOCIO SANITARIA TERRITORIALE (ASST) GRANDE OSPEDALE METROPOLITANO NIGUARDA; Universitätsklinikum Aachen; University of Edinburgh; Universitat Pompeu Fabra (UPF) | CORDIS-720270 | Understanding the human brain is one of the greatest scientific challenges of our time. Such an understanding can provide profound insights into our humanity, leading to fundamentally new computing technologies, and transforming the diagnosis and treatment of brain disorders. Modern ICT brings this prospect within reach. The HBP Flagship Initiative (HBP) thus proposes a unique strategy that uses ICT to integrate neuroscience data from around the world, to develop a unified multi-level understanding of the brain and diseases, and ultimately to emulate its computational capabilities. The goal is to catalyze a global collaborative effort. During the HBP’s first Specific Grant Agreement (SGA1), the HBP Core Project will outline the basis for building and operating a tightly integrated Research Infrastructure, providing HBP researchers and the scientific Community with unique resources and capabilities. Partnering Projects will enable independent research groups to expand the capabilities of the HBP Platforms, in order to use them to address otherwise intractable problems in neuroscience, computing and medicine in the future. In addition, collaborations with other national, European and international initiatives will create synergies, maximizing returns on research investment. SGA1 covers the detailed steps that will be taken to move the HBP closer to achieving its ambitious Flagship Objectives. | H2020-EU.1.2. / 1.2 Future and Emerging Technologies (FET) | 6project_grants_public
|
gen_0b851e601cc1ae7f5222f61bea28eee3 | Optimised moulded pulp for renewable packaging solutions | European Commission | NOVAMONT SPA | CORDIS-720744 | The aim of PULPACKTION project is to develop cellulose-based tailored-to-purpose packaging solutions for specific food and electronic packaging applications which needs medium and high barrier requirement’s and that nowadays are packing in polymer fossil based solutions. This innovation will take advantage of the flexibility in the wet-moulding production of wood pulp based materials. Different types of wood pulp will be combined to prepare slurries for wet-moulding applications. These slurries will be additivated with biopolymers and other bio-based compounds in order to tailor the final properties of the resulting wet-moulded materials. By tailoring the composition of the wet mouldable slurry, a wide range of final properties in the resulting dry material will be achieved. This flexible packaging manufacturing system will be combined with 100% bio-based coatings and films on the cellulose-based substrate. To fulfil the properties required for PULPACKTION’s specific packaging applications using a fully bio-based approach, additional barriers will be implemented onto the wet moulded substrate. For this purpose, new bio-based polymer blends will be optimized. These new blends, containing biopolymers such as thermoplastic starch (TPS), poly (lactic acid) (PLA), other bio-additives, and reinforcements such as microfibrillated cellulose (MFC), will be processed into multilayer films, composites and coatings. In this manner, not only coatings for improved barrier properties, but also 100% bio-based films for packages’ top lids will be produced. Therefore, a final 100% bio-biobased integral packaging solution with similar properties to existing fossil-based packaging solutions will be achieved. | H2020-EU.3.2. / 3.2 Societal Challenges - Food | 0business_rnd_innovation
|
gen_616f723f19ac34b2f446acd7ef3a53d0 | EU TRADE AND INVESTMENT POLICY | European Commission | CENTRE D'INFORMATION ET DE RECHERCHE SUR L'ECONOMIE MONDIALE; Herdem Attorneys at Law | CORDIS-721916 | International trade and investment are of considerable economic and political importance for Europe. The EU is negotiating trade agreements globally, involving the abolition of tariffs, the reduction of non-tariff barriers to trade, and the introduction of dispute settlement mechanisms. However, the example of the controversial TTIP has shown the challenges of EU trade policy. The objective of the EU Trade and Investment Policy ITN (EUTIP) is to foster interdisciplinary research into the evolving international trade policy of the EU with a view to create a significantly increased European knowledge base and research capacity on EU law and policy of the regulation of international trade through free trade agreements (FTAs) with third countries, thus helping Europe to safeguard the benefits of international trade (wealth, jobs, etc.) while addressing the challenges of its regulation (competence, democracy, accountability, environmental- and labour, standards, etc.). It is argued that the EU trade and investment policy pursued through FTAs will lead to the evolution of an entirely new legal sub-discipline closely related to and originating in EU law and international trade law. This new field of law will be wide-ranging, including aspects already addressed in existing FTAs and fields of trade and competition law currently regulated in the Treaty on the Functioning of the EU (TFEU), the relevant decision-making mechanisms, the relationship between the relevant legal systems, and dispute settlement. Moreover, the ITN investigates Transatlantic agreements as precedents and possible templates for third generation trade agreements of the EU with other parts of the world. The network is an interdisciplinary, intersectoral collaboration pooling world-leading researchers and practitioners from all relevant disciplines of law - EU constitutional, internal market, and external relations law, international trade law, and international law, as well as political science, international relations, business studies, and economics. EUTIP fully integrates non-academic Beneficiaries (Ben) and Partner Organisations (PO), including think tanks, lobbyists, regulatory bodies, law firms, US academic institutions, and an international organisation. Furthermore, the network will support and enhance the process of converting research results into policy papers through partnership with high-impact policy research units at the forefront of European policy research and policy making. The work package consists of 3 substantive work packages on (1) governance, (2) regulation, and (3) multilateralism and regionalism. 15 PhD research projects will be supervised by academics of the 11 Beneficiaries with an interdisciplinary training programme covering the legal, political and economic foundations of EU trade and investment policy and an interdisciplinary and intersectoral programme of secondments involving 18 Partner Organisations. | H2020-EU.1.3. / 1.3 Marie Skłodowska-Curie Actions (MSCA) | 6project_grants_public
|
gen_1be0f913837d120f3eac8fa6d79af10e | Industrial Feather Waste Valorisation for Sustainable KeRatin based MAterials. | European Commission | VERTECH GROUP SARL; Centre national de la recherche scientifique; RISE PROCESSUM AB | CORDIS-723268 | According to European Commission, 13.1 million tons of poultry meat was produced only in the European Union (EU-28) in 2014 with an estimated generation of 3.1 million tons feather waste. At present the majority of poultry feathers are converted into low nutritional value animal food or disposed in landfills, causing environmental and health hazards. In this context, the overall objective of KaRMA2020 is the industrial exploitation of such underutilized waste to obtain added value raw materials for the chemical sector: keratin, bioplastics, flame retardant coatings, non-woven and thermoset biobased resins. This will be accomplished through either: i) innovative and sustainable approaches (already patented by some of KaRMA2020 partners), or ii) conventional and economic techniques. The obtained raw materials will be manufactured at industrial scale and further used for the production of novel bio-based products such as: slow release fertilizers, biodegradable food packaging plastics, flame retardant coated textiles and flame retardant thermoset biobased composites. The sustainability of the new raw materials and end-products will be evaluated through LCA assessment. Additionally, an integrated waste management plan will be elaborated to minimize environmental impacts generated by wastes. Communication and knowledge transfer as well as a detailed business plan will allow maximizing overall profitability of KaRMA2020 results. The well balanced composition of the consortium including industry, RTD performers and academia give KaRMA2020 the maximum chance of success. | H2020-EU.2.1.5. / 2.1.5 LEIT - Advanced manufacturing and processing | 0business_rnd_innovation
|
gen_9a9b939483dfc8fc53e89e46ee539d56 | Integrated Arctic observation system | European Commission | OCEAN NETWORKS CANADA | CORDIS-727890 | The overall objective of INTAROS is to develop an integrated Arctic Observation System (iAOS) by extending, improving and unifying existing systems in the different regions of the Arctic. INTAROS will have a strong multidisciplinary focus, with tools for integration of data from atmosphere, ocean, cryosphere and terrestrial sciences, provided by institutions in Europe, North America and Asia. Satellite earth observation data plays an increasingly important role in such observing systems, because the amount of EO data for observing the global climate and environment grows year by year. In situ observing systems are much more limited due to logistical constraints and cost limitations. The sparseness of in situ data is therefore the largest gap in the overall observing system. INTAROS will assess strengths and weaknesses of existing observing systems and contribute with innovative solutions to fill some of the critical gaps in the in situ observing network. INTAROS will develop a platform, iAOS, to search for and access data from distributed databases. The evolution into a sustainable Arctic observing system requires coordination, mobilization and cooperation between the existing European and international infrastructures (in-situ and remote including space-based), the modeling communities and relevant stakeholder groups. INTAROS will include development of community-based observing systems, where local knowledge is merged with scientific data. An integrated Arctic Observation System will enable better-informed decisions and better-documented processes within key sectors (e.g. local communities, shipping, tourism, fisheries), in order to strengthen the societal and economic role of the Arctic region and support the EU strategy for the Arctic and related maritime and environmental policies. | H2020-EU.3.2. / 3.2 Societal Challenges - Food | 6project_grants_public
|
gen_6a967b3e7ee983d35867c1ab28bbf02b | Establishing the European Geological Surveys Research Area to deliver a Geological Service for Europe | European Commission | INSTITOUTO GEOLOGIKON KAI METALLEFTIKON EREVNON; FEDERALNI ZAVOD ZA GEOLOGIJU SARAJEVO | CORDIS-731166 | The GeoERA proposal is put forward by the national and regional Geological Survey Organisations (GSO) of Europe. Its overall goal is to integrate the GSO’s information and knowledge on subsurface energy, water and raw material resources, to support sustainable use of the subsurface in addressing Europe’s grand challenges. The GeoERA consortium will organise and co-fund together with the EC a joint call for transnational research projects that address the development of 1) interoperable, pan-European data and information services on the distribution of geo-energy, groundwater and raw material resources; 2) common assessment frameworks and methodologies supporting better understanding and management of the water-energy-raw materials nexus and potential impacts and risks of subsurface use; 3) knowledge and services aimed at European, national and regional policy makers, industry and other stakeholders to support a more integrated and efficient management and more responsible and publicly accepted exploitation and use of the subsurface. The transnational projects selected in the call will be implemented by the consortium partners themselves, who provide their co-funding in-kind. GeoERA will contribute to the overall EU objective of building the ERA through enhanced cooperation and coordination of national and regional Geological Survey research programmes. GeoERA will also include forward looking activities, including the creation of opportunities for future collaborative research, and the feasibility assessment of an Article 185 initiative in Applied Geoscience as follow-up to the GeoERA ERA-NET towards the development of the ultimate goal of delivering a Geological Service for Europe. | H2020-EU.3.3. / 3.3 Societal Challenges - Energy | 6project_grants_public
|
gen_e0913fc28a64c40867d0ee7ee0b2ffa7 | Additive Manufacturing Initiative for Transnational Innovation in Europe | European Commission | INSTITUT STRAUMANN AG | CORDIS-734342 | Additive manufacturing (AM) technologies and overall numerical fabrication methods have been recognized by stakeholders as the next industrial revolution bringing customers’ needs and suppliers’ offers closer. It cannot be dissociated to the present trends in increased virtualization, cloud approaches and collaborative developments (i.e. sharing of resources). AM is likely to be one good option paving the way to Europe re-industrialization and increased competitiveness. AMITIE will reinforce European capacities in the AM field applied to ceramic-based products. Through its extensive programme of transnational and intersectoral secondments, AMITIE will promote fast technology transfer and enable as well training of AM experts from upstream research down to more technical issues. This will provide Europe with specialists of generic skills having a great potential of knowledge-based careers considering present growing needs for AM industry development. To do that, AMITIE brings together leading academic and industrial European players in the fields of materials science/processes, materials characterizations, AM technologies and associated numerical simulations, applied to the fabrication of functional and/or structural ceramic-based materials for energy/transport, and ICTs applications, as well as biomaterials. Those players will develop a new concept of smart factory for the future based on 3D AM technologies (i.e. powder bed methods, robocasting, inkjet printing, stereolithography, etc.) and their possible hybridization together or with subtractive technologies (e.g. laser machining). It will allow for the production of parts whose dimensions, shapes, functionality and assembly strategies may be tailored to address today’s key technological issues of the fabrication of high added value objects following a fully-combinatorial route. This is expected to lead to a new paradigm for production of multiscale, multimaterial and multifunctional components and systems | H2020-EU.1.3. / 1.3 Marie Skłodowska-Curie Actions (MSCA) | 6project_grants_public
|
gen_948396de07f9897ced5043afb20e42ec | DISRUPTING LITERACY CONTENT CREATION PLATFORM FOR EDUCATORS ENABLING ADAPTIVE AND FLEXIBLE LEARNING FOR KIDS | European Commission | Myabckit | CORDIS-735804 | This is a re-submission of the last call, having improved the weak points (attached ESR after section 5). The UNESCO found that at least 250 of the world’s 650 million primary school age children are unable to read, write or do basic mathematics even if they are in primary school (130 million). Furthermore, they calculated that the cost of 250 million children around the world not learning translates to a loss for governments of around 120 billion euros annually. myABCKit aims to democratize the access to innovative literacy learning methodologies based on Maria Montessori’s methods (That usually are quite expensive not accesible for everyone). Using new ICT methodologies to revolutionize and empower new kids formal and non-formal education methodologies based on teaching HOW to think instead of WHAT to think. myABCKit is accessible from any device and is based in three main areas around the adaptive learning overall concept: • Content creation tools for educators to be able to personalise content in terms of context, interest, familiarity and language. • New business models around literacy content through a marketplace where educators and schools can monetize their creativity. • Play-based exercises focused on literacy for kids: vocabulary, grammar, reading and comprehension of one or more languages for K-12 students. • Learning analytics foe schools and educators in order to know the evolution and early detection of learning disabilities to improve their academic results by applying adaptive learning. Thanks to myABCKit disruptive app, the market opportunities and the EC support, it is expected to reach over 1 million kids and generate over 100 million EUR in revenues in 2022. Moreover, the results of this project will catapult myABCKit as a leader in the global adaptive e-Learning market, the first play-based literacy-learning app for kids maximizing the benefits of ICT and Montessori’s methodology in a unique, smart and friendly ecosystem. | H2020-EU.3.6. / 3.6 Societal Challenges - Europe in a changing world | 0business_rnd_innovation
|
gen_ca1dbd42c084169b4c0ee423d0ca01d3 | Fifth Generation Communication Automotive Research and innovation | European Commission | Volvo Cars | CORDIS-761510 | There are two ongoing industrial trends, one in the mobile communications industry and one in the automotive industry, which are becoming interwoven and will jointly provide new capabilities and functionality for upcoming intelligent transport systems and future driving. The automotive industry is on a path where vehicles are continuously becoming more aware of their environment, due to a permanent increase in various types of integrated sensors; at the same time the amount of automation in vehicles increases, which – with some intermediate steps – will eventually culminate in fully-automated driving without human intervention. Along this path, the amount of interactions increases, both in-between vehicles, as well as between vehicles and an increasingly intelligent road infrastructure. As a consequence, the significance and reliance on capable communication systems for vehicle-to-anything (V2X) communication is becoming a key asset that combined with sensor-based technologies will enhance the performance of automated driving and increase further traffic safety. On the other hand, the mobile communications industry has over the last 25 years connected more than 5 billion people and mobile phones have become part of our daily living. The next step in wireless connectivity is to connect all kinds of devices that can benefit from being connected, with a total of 28 billion connected devices predicted until 2021. It will support the transformation of industries on their journey of digitization. In this step, mobile communications has the ambition to explicitly target the communication needs of vertical industry with corresponding requirements being set for the standardization of 5G until 2020. 5GCAR brings together a strong consortium from the automotive industry and the mobile communications industry, to develop innovation at the intersection of those industrial sectors in order to support a fast, and successful path towards safer and more efficient future driving. | H2020-EU.2.1.1. / 2.1.1 LEIT - ICT | 0business_rnd_innovation
|
gen_7ca98ca9523b7a74ceef489ec0cd7471 | Innovative compact HYbrid electrical/thermal storage systems for low energy BUILDings | European Commission | OCHSNER WARMEPUMPEN GMBH; COMSA EMTE | CORDIS-768824 | HYBUILD will develop two innovative hybrid storage concepts: one for the Mediterranean climate primarily meant for cooling energy provision, and one for the Continental climate primarily meant for heating and DHW production. HYBUILD action is a systematic approach for developing operationally integrated thermal and electric components and systems from TRL4 to TRL6 and beyond. The hybrid storage concepts are based on: a compact sorption storage, based on a patented way to integrate an innovative adsorbent material within an efficient high surface heat exchanger, a high density latent storage, based on a high performance aluminum micro-channel heat exchanger with additional PCM layers, and an efficient electric storage. The balancing of thermal and electrical energy flows will be realized by seamless integration of electric building components in a DC coupled system and by efficient conversion and upgrading of electric surplus and renewable thermal energy sources by compression and adsorption heat pumps. The components will be integrated to realize the full-scale hybrid storages (with overall volume between 1 and 2 m3), which will be properly managed by advanced control and building energy management systems (BEMS), able to optimize the interactions between components and district network. Such a configuration will allow reaching energy savings ranging between 20 and 40%, on yearly basis, both in Mediterranean and Continental climate for non-connected and district-connected buildings. HYBUILD hybrid storages will be used to upgrade existing building configurations and monitored in three different demo sites in near-life operation, both for non-connected and district-connected buildings in different climates. | H2020-EU.2.1.5. / 2.1.5 LEIT - Advanced manufacturing and processing | 0business_rnd_innovation
|
gen_a07c6dd830906043d5f87eacd36e8b2a | Pan-European system with an efficient coordinated use of flexibilities for the integration of a large share of RES | European Commission | INNOGY SE; WRD WOBBEN RESEARCH AND DEVELOPMENT GMBH | CORDIS-773505 | The overall objective is to ensure an efficient and sufficient level of system services are provided to facilitate meeting world leading levels of RES-E while maintaining the level of resilience that consumers and society have come to expect from the European electricity system. This requires defining the right amount of flexibility and system services to support transmission system operators using a threefold approach. Firstly, the technical needs of the pan-European system will be defined for scenarios with more than 50% RES-E in will be identified and translated to services and products to be delivered in an enhanced market design. Secondly, the electricity market design and regulation needs to be augmented to efficiently and effectively procure the appropriate combination of these system services. Thirdly, implicit and explicit barriers to competitive forces being applied need to be removed. This requires an in-depth understanding of all stakeholders’ roles (Generation and flexibility providers, Transmission system operators (TSO) and Distribution System Operators (DSO) and regulators) at all system levels (interconnected system, national transmission and distribution sub-systems and consumers). For doing so, EU-SysFlex joins a multidisciplinary team of 34 partners from 14 European countries, led by the (Transmission System Operators) TSOs representing four different synchronous systems that integrate the pan-European interconnected electricity system: EirGrid & SONI (Ireland), PSE (Poland), AST (Latvia), Elering (Estonia), supported by the necessary (Distribution System Operators) DSOs, technology providers, and research & experienced entities. In addition, a group of three other European TSOs: Fingrid (Finland), LitGrid (Lithuania) and Ceps (Czech Republic), will join the advisory board of the project, in addition to EDSO for Smart Grids and USEF, in order to help the project maximising its impact. | H2020-EU.3.3. / 3.3 Societal Challenges - Energy | 6project_grants_public
|
gen_54887b470bd33d2b38b6ddd8bc49a533 | productive Green Infrastructure for post-industrial urban regeneration | European Commission | ASOCIATIA DE DEZVOLTARE INTERCOMUNITARA ZONA METROPOLITANA - CLUJ | CORDIS-776528 | For proGIreg three front-runner cities (Dortmund (DE); Turin (IT); Zagreb (HR))will create Living Labs in urban areas which face the challenge of post-industrial regeneration. These areas suffer from social and economic disadvantages, inequality and related crime and security problems. They lack quality greenspaces, have a negative impact on human health and wellbeing and are more vulnerable to the effects of climate change. Going beyond the current state-of-the-art with Green Infrastructure as a one-off state intervention, the proGIreg Living Labs will develop NBS which are citizen owned and co-developed by state, market and civil society stakeholders. Innovation will take place on the technical level through the NBS deployments, on the social level through co-designing, co-creating and co-implementing NBS with local communities and on the economic level through combining NBS with market-ready business models. Four follower cities in Eastern and Southern Europe (Cascais PT, Cluj-Napoca RO, Piraeus GR, Zenica BA) will be co-steering the research process to assure replicability and adaptability to their local context resulting in urban plans for NBS deployment. The NBS to be tested i.a. include: regenerating industrial soils biotic compounds, creating community-based urban agriculture and aquaponics and making renatured river corridors accessible for local residents. Scientific assessment and monitoring results from the Living Labs will be made available on the EU NBS platforms OPPLA and THINKNATURE and will contribute to the European reference framework for NBS. Global impact will be achieved by a training programme for cooperative planning, implementation and management of NBS. It will be provided by partners from the cities, SMEs and universities involved. Training events will be organised in cooperation with the partner ICLEI. Massive Open Online Courses (MOOCs) will be distributed via EdX, the most renowned MOOCs platform worldwide. | H2020-EU.3.5. / 3.5 Societal Challenges - Climate | 6project_grants_public
|
gen_15829c19ae0b8ae0b3610e5c054f32b2 | Transforming Weather Water data into value-added Information services for sustainable Growth in Africa | European Commission | STRATHMORE UNIVERSITY; FUTUREWATER SL | CORDIS-776691 | Objectives: Provide currently unavailable geo-information on weather, water and climate for sub-Saharan Africa by enhancing satellite-based geo-data with innovative in situ sensors and developing related information services that answer needs of African stakeholders and the GEOSS community. Concept: A systematic feedback loop to reciprocally validate in situ measurements and satellite data in one integrated model. Over 500 in situ measurement stations using citizen science. State of the art advancement & Innovation potential: Building on and pushing further recent advances in sensor and communication technology to provide cheaper and more robust in situ measurements covering a wider area at a higher resolution in sub-Saharan Africa. Working with tech-hubs in Europe and Africa to feed creation and growth of European and African start-ups that develop sensors and geo-services, delivering complete value chains from sensor to customer-ready information delivery. Impact on call expectations: -Integration of in situ components into models based on GEOSS and Copernicus data -OGC compliant science-grade geo-data (atmosphere, hydrosphere, biosphere) delivered to GEOSS, incl. near-real time statistically characterized soil moisture data from Africa that can be used operationally (not currently available) and radar derived soil moisture measurements also available under cloudy conditions, or vegetation overgrowth -at least 20 new products for use in food, water, energy security, climate change and resilience to natural hazards validated and ready for large-scale implementation by consortium partners and external stakeholders -based on at least 10 innovative, cost efficient, robust, sensors, including fast neutron coun-ter, track¬ing of convective storms with consumer lightning sensors and accelerometer for tree-crown weighing -(Bio-degradable) sensors reduced to one tenth to one hundredth of their current price, extremely low-maintenance, use of Unmanned Aerial Vehicles. | H2020-EU.3.5. / 3.5 Societal Challenges - Climate | 6project_grants_public
|
gen_b0fce35585e403da1fe26c1c1fef5b2c | URBiNAT - Healthy corridors as drivers of social housing neighbourhoods for the co-creation of social, environmental and marketable NBS | European Commission | NEW GROWING SYSTEMS SL; ASSOCIACAO BIOPOLIS; UNIVERSITET PO ARCHITEKTURA STROITELSTVO I GEODEZIJA | CORDIS-776783 | URBiNAT focuses on the regeneration and integration of deprived social housing urban developments through an innovative and inclusive catalogue of Nature-Based Solutions (NBS), ensuring sustainability and mobilising driving forces for social cohesion. Interventions focus on the public space to co-create with citizens new urban, social and nature-based relations within and between different neighbourhoods. Taking the full physical, mental and social well-being of citizens as its main goal, URBiNAT aims to co-plan a healthy corridor as an innovative and flexible NBS, which itself integrates a large number of micro NBS emerging from community-driven design processes. URBiNAT consists of a worldwide consortium of academic and business partners around 7 European cities (Porto, Nantes and Sofia as ‘frontrunners’; Siena, Nova Gorica, Brussels and Høje-Taastrup as followers), that will act as living laboratories to implement healthy corridor solutions. The cities will be supported by local partners, associations and research centres, and by Europe-wide centres, universities and companies. These will develop a participatory process, an NBS catalogue and a healthy corridor, while monitoring impacts, disseminating and marketing results. Together, they form an inclusive community of practice (CoP), collaborating with partners from Iran and China, and NBS observers located in Brazil, Oman, Japan and a Chinese city, bringing experiences and an international dimension to the project. Partners will contribute their innovative NBS experience deployed through an array of transdisciplinary knowledge, methodologies and tools, as nature-based solutions. This will be supplmented by ‘smart’ digital tools, citizen engagement, solidarity and social economy initiatives, social innovation for value-generation, incubation for business development and capacity building, and ICT governance platforms. The social, economic and urban impacts will be measured and replicated by URBiNAT Observatory. | H2020-EU.3.5. / 3.5 Societal Challenges - Climate | 6project_grants_public
|
gen_417df97233d9a55fa24a05a663b1604d | Farmer clusters for Realising Agrobiodiversity Management across Ecosystems | European Commission | University of Natural Resources and Life Sciences | CORDIS-862731 | FRAMEwork is constructed based on the Farmer Cluster approach successfully implemented in the UK. FRAMEWORK will enrich and innovate existing Farmer Clusters by liaising with local and (inter)national stakeholder groups, and set up new, multi-actor, Farmer Clusters in different cropping systems in Europe, based on existing collaborations. The Farmer Clusters will be united in a European-wide self-sustaining network and linked with the Citizen Observatory and Information Hub that will facilitate farmer and citizen-based collection and sharing of harmonised, high-quality information on biodiversity and farming, and develop engaging online and offline activities to amplify awareness and understanding of biodiversity and Biodiversity Sensitive Farming across different stakeholders in Europe. The scientific contribution to these citizen-based activities will deliver the following outcomes: 1) Advanced ecological understanding of the drivers of biodiversity change in agricultural landscapes; 2) a selection of best-practice biodiversity-sensitive management by farmers based on their local requirement; 3) validated methods for biodiversity targeting, monitoring and evaluation and 4) private and public incentives to foster biodiversity-sensitive farming as a public good. Furthermore, FRAMEwork will assess the effectiveness of the Farmer Cluster approach to develop and implement place and system-specific biodiversity-sensitive farming practices and evaluate the economic and environmental performance, delivering a permanent on-line evaluation tool on the Citizen Observatory and Information Hub. The TRL of the Decision Support Tools ranges from 3-5, where improvements are foreseen for the TRL5 Decision Support Tool, while the ones at TRL3 will be brought to TRL4-5 through testing and improvements in the Farmers Clusters. FRAMEwork will be innovative in the way in which it will implement EU ethics, data protection and gender regulations. | H2020-EU.3.2. / 3.2 Societal Challenges - Food | 6project_grants_public
|
gen_380234b321cc09681102a4f8c9764de7 | A POsitive Energy CITY Transformation Framework | European Commission | UBIWHERE Lda | CORDIS-864400 | POCITYF supports the Lighthouse cities of Evora (PT) and Alkmaar (NL) and their Fellow cities Granada (ES), Bari (ΙΤ), Celje (SI), Ujpest (HU), Ioannina (GR) and Hvidovre (DK) to address their urgent need to deliver positive energy blocks and districts in their cities, towards rendering their mixed urban environment (also including the case of cultural protected buildings) into cheaper, better accessible, healthier and more reliable. By demonstrating in overall 10 integrated solutions (ISs), comprising 73 individual innovative elements (technologies, tools, methods), rooted under existing City Information Platforms (CIPs), POCITYF quantifies their value, and connects interests of many different stakeholders in innovative business models, allowing for upscale and replication of those solutions in a form of a validated roadmap for sustainable cities across Europe and world-wide. To achieve this, POCITYF works along 4 Energy Transition Tracks (ETTs), encompassing the ISs according to the role each one serves for. ETT#1 focuses on the examination and application of ISs transforming existing and new building stock into Energy Positive, while ETT#2 focuses on the application of a) grid flexibility strategies and b) storage systems, supported by DSM platforms for optimizing energy flows to maximize self-consumption and reduce grid stress. ETT#3 with its merit of innovation offers the integration of e-Mobility to as well promote the decarbonisation of the mobility sector. The 3 ETTs under the coordination of ETT#4, which links existing CIPs with innovative apps and other instruments, offers inclusive and holistic services for interdisciplinary citizen engagement and co-creation of them with the city stakeholders and industry, towards the development of each city’s own bold city-vision up to 2050. Through POCITYF the two LHs will achieve a local RES penetration of 16.2 GWh/y, energy savings of 2.32 GWh/y and an emission reduction of 9,743 tons CO2eq/y within their districts. | H2020-EU.3.3. / 3.3 Societal Challenges - Energy | 6project_grants_public
|
gen_69faa52bad81878ffe18802a1226cc60 | illuMINEation --- Bright concepts for a safe and sustainable digital mining future | European Commission | VEITSCH-RADEX GMBH & CO OG | CORDIS-869379 | The (European) mining industry is under great pressure due to a number of reasons, e.g. high number of injuries/fatalities and environmental accidents, bad reputation, low commodity prices, depleting resources and decreasing ore grades, etc. The only way to overcome these challenges is to completely “rethink” the process of traditional mining via progressively digitising mining operations and introducing ground-breaking innovations (e.g. remote controlled robots, autonomous drones, novel sensor systems, etc.), accompanied by the extensive use of data analytics and new forms of Industrial Internet of Things (IIoT). illuMINEation will illuminate important digitalization aspects in underground mining operations in order to achieve the next level of safety, environment and economic performance, and to retain and gain a social licence to operate. The project will develop a robust multi-level distributed IIoT platform (including cloud computing & distributed cloud management) that connects via wireless communication with the physical mining world, defined by massively installed low-cost all-embracing sensor networks. Advanced analytical algorithms will support the implementation of powerful, sophisticated automated control systems. Mobile user interfaces, dashboards, augmented and virtual reality as well as digital twins will be utilised for data visualisation and operational control. illuMINEation will ensure that all mining personnel receive the best possible information that the enormous amount of data has to offer, whilst ensuring all data is properly protected via a rigorous cyber security approach. The illuMINEation consortium provides the necessary resources and comprehensive skills and capabilities to operate across organizational boundaries with the aim to bring together the different parts of the entire digital mining business value chain and create cross-industry innovations. | H2020-EU.3.5. / 3.5 Societal Challenges - Climate | 0business_rnd_innovation
|
gen_7d224695c51b346eba8cce3f6b78a556 | REsilient WAter Innovation for Smart Economy | European Commission | ASOCIACION DE INDUSTRIAS DE LAS TECNOLOGIAS ELECTRONICAS Y DE LA INFORMACION DEL PAIS VASCO GAIA | CORDIS-869496 | REWAISE will create a new “smart water ecosystem”, mobilising all relevant stakeholders to make society embrace the true value of water, reducing freshwater and energy use, resulting in a carbon free, sustainable hydrological cycle, to transition into a resilient circular economy. A network of nine living labs, involving 5 major water utilities, demonstrates real-life, large-scale operational environments for technological innovations and new governance methods to secure a resource-efficient water supply for the EU. New business niches will be created, incentivizing water-related investments, and accelerating SME growth, by linking users with specific water needs, incorporating life cycle and cost assessments, and collective action in new governance frameworks for smart value creation and high social returns. By incorporating paradigm shifts from a linear Roman heritage to a new circular, water-smart economy, REWAISE reveals the full Value of Water for Europe, considering 3 key components of the economic and societal value generated by integral water cycles: • Value in Water: is accomplished by extracting and putting to beneficial use dissolved substances such as nutrients, minerals, chemicals and metals, as well as organic matter and energy, embedded in raw and used water streams. • Value from Water: encompasses the economic activities inherent to the water cycle, related products and services that generate benefits and jobs, directly or in other sectors that depend on water, such as energy and transportation, • Value through Water: the societal, health and well-being functions of water, which will be enhanced by inter-linking users, regulators, water operators and other stakeholders in electricity and chemicals markets through a digital platform that optimizes decision making and business opportunities through socio-economics-based coordination between them, while minimizing emissions , risks and vulnerability. | H2020-EU.3.5. / 3.5 Societal Challenges - Climate | 6project_grants_public
|
gen_6bc818ea77762eec402d2c680f9030a0 | Digital Platform for Circular Economy in Cross-sectorial Sustainable Value Networks | European Commission | INDRA SAS; SAUBERMACHER DIENSTLEISTUNGS AG; HOLONIX SRL-SPIN OFF DEL POLITECNICO DI MILANO; KNORR-BREMSE SYSTEME FUR NUTZFAHRZEUGE GMBH | CORDIS-873111 | DigiPrime has the mission to develop a new concept of Circular Economy digital platform overcoming current information asymmetry among value-chain stakeholders, in order to unlock new circular business models based on the data-enhanced recovery and re-use of functions and materials from high value-added post-use products with a cross-sectorial approach. DigiPrime will create and operate a federated model of digital platforms for cross-sector business in the Circular Economy. Nodes of the federation will offer interoperable functions and data, that can be accessed by other nodes, combined with local data and services, that are not exposed outside; connectors and open interfaces enable easy integration of new services, provided by third parties, that are not made accessible outside. Specific attention will be devoted to create trustable data sharing mechanisms, preserving the confidentiality of business-critical data. Security and sovereignity of information are guaranteed by IDSA (Industrial Data Space Association)-based solutions for on-demand and controlled sharing of data among organisations, regulated by smart contracts and tracked by block-chain. The services covers: i) the cross-sector value-Chains dimension (De- and remanufacturing oriented product information management, product co-creation, LCA-LCC for eco-design, demand-supply matching, sustainable value network and reverse logistics barriers identification and legislation support, etc.), ii) the operational dimension (rediction of product conditions, de-and remanufacturing decision support system, demand and supply forecasting, circular production planning and control, material testing and certificationetc). DigiPrime, will be thoroughly validated through 6 cross-sectorial pilots, further detailed in 20 use-cases covering 5 different European industrial sectors (automotive, renewable energy, electronics, textile, construction), and by additional pilots in new sectors, funded through an Open Call mechanism. | H2020-EU.2.1.1. / 2.1.1 LEIT - ICT | 6project_grants_public
|
gen_72c8d6ae85f892d97d1b6f62cac65e3d | The CALIPER project: Linking research and innovation for gender equality | European Commission | VILABS OE | CORDIS-873134 | The CALIPER project aims at driving a structural change process and implementing Gender Equality Plans in 7 Research Performing and 2 Research Funding organizations, involving the highest and middle management levels since the beginning to impact the whole institution. The project goal is to make research organizations more gender equal by increasing the number of female researchers in STEM, improving their careers prospects and integrating a gender dimension in research. CALIPER is featured by a broad geographic focus and an innovative approach based on engaging national and regional innovation ecosystems in the partners’ countries with a quadruple helix approach: the project will trigger and make internal changes and gender equality policies sustainable by orchestrating the core inward auditing/internal assessment and GEPs design with outward actions engaging external stakeholders to activate synergies at all different junctions of the ‘education-research- transfer to market of STEM research results’ chain. CALIPER will adopt an intersectional approach to gender equality issues, paying attention to the ways gender inequalities are linked to and intersected with other discriminations. CALIPER will ensure its successful implementation by adopting a holistic methodology featured by capacity building support to build and sustain internal gender knowledge and expertise, mutual learning among partners, a participatory co-design of GEPs as well as 2 iteration levels for implementing and refining GEPs and a thorough monitoring and evaluation mechanism, leading to durable institutional changes. Thanks to the presence of α pan- European Professional association in the consortium and further dissemination actions such as the Caliper Charter and Code and awareness raising sessions on gender in research open to external stakeholders and other RPOs/RFOs , Caliper results have strong potentials to be multiplied both nationally and in other EU28 countries. | H2020-EU.5. / 5.0 Science with and for Society | 6project_grants_public
|
gen_80415a606190d47acdf25c51867ae9f2 | Human Brain Project Specific Grant Agreement 3 | European Commission | INSTITUTE OF EXPERIMENTAL MEDICINE - HUNGARIAN ACADEMY OF SCIENCES; Universitätsklinikum Aachen; Barcelona Supercomputing Center - Centre Nacional de Supercomputació (BSC-CNS); KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW; POLYTECHNEIO KRITIS; KUNGLIGA TEKNISKA HOEGSKOLAN; AI2LIFE SRL; Universidad Autónoma de Madrid | CORDIS-945539 | The last of four multi-year work plans will take the HBP to the end of its original incarnation as an EU Future and Emerging Technology Flagship. The plan is that the end of the Flagship will see the start of a new, enduring European scientific research infrastructure, EBRAINS, hopefully on the European Strategy Forum on Research Infrastructures (ESFRI) roadmap. The SGA3 work plan builds on the strong scientific foundations laid in the preceding phases, makes structural adaptations to profit from lessons learned along the way (e.g. transforming the previous Subprojects and Co-Design Projects into fewer, stronger, well-integrated Work Packages) and introduces new participants, with additional capabilities. The SGA3 work plan is built around improved integration and a sharpening of focus, to ensure a strong HBP legacy at the end of this last SGA. In previous phases, the HBP laid the foundation for empowering empirical and theoretical neuroscience to approaching the different spatial and temporal scales using state-of-the-art neuroinformatics, simulation, neuromorphic computing, neurorobotics, as well as high-performance analytics and computing. While these disciplines have been evolving for some years, we now see a convergence in this field and a dramatic speeding-up of progress. Data is driving a scientific revolution that relies heavily on computing to analyse data and to provide the results to the research community. Only with strong computer support, is it possible to translate information into knowledge, into a deeper understanding of brain organisation and diseases, and into technological innovation. In this respect, the underlying Fenix HPC and data e-infrastructure, co-designed with the HBP, will be key. The services offered by EBRAINS will be grouped in six Service Categories: SC1: Curated and shared data: EBRAINS FAIR data services - neuroscience data publishing SC2: Brain atlas services: navigate the brain in 3D - find, contribute and analyse brain data, based on location SC3: Brain modelling and simulation workflows: integrated tools to create and investigate models of the brain SC4: Closed loop AI and robotics workflows: design, test and implement robotic and AI solutions SC5: Medical Data Analytics SC6: Interactive workflows on HPC or NMC: Europe-wide access to scalable and interactive compute services Their users are to be supported with High-Level Support Teams and Vouchers, as well as Engagement and Facility Hubs located around Europe, at which additional services, unique equipment and compute infrastructure will be offered by local HBP Partners. Significant outcomes in relevant scientific communities are expected to materialise rapidly. Association with new Partnering Projects is still sought, along with wider international cooperation. The SGA3 objectives can be summarised as: 1)Establish a sustainable European scientific research infrastructure, EBRAINS, leading to an increased use and adoption of FAIR data, web-based analyses, model building, simulation, atlasing, and virtual experiments for brain research and brain-inspired sciences. 2)Provide a multi-level atlas of the human brain - the first of its kind that links microstructural detail and inter-subject variability. 3)Increase the capacity of neuroscientists for multiscale neural activity modelling of the human brain network. 4)Increase the availability of integrated multiscale data and computational models supporting brain states transitions, network complexity and cognitive functions. 5)Enhance real-world task performance through biologically plausible adaptive cognitive architectures running on neuromorphic hardware and a closed-loop Neurorobotics Platform. 6)Ensure that neuroscientific insights at the interface of neuro-inspired computing and technology are being translated into a benefit for patients with brain diseases. 7)Ensure an ethically and legally compliant infrastructure and promote embedding of Responsible Research and Innovation, a | H2020-EU.1.2. / 1.2 Future and Emerging Technologies (FET) | 6project_grants_public
|
gen_e64676ab6e3facb8a5dd48b9862e382f | Grow your manufacturing business | European Commission | HOLONIX SRL-SPIN OFF DEL POLITECNICO DI MILANO; University of Oulu; Fraunhofer Gesellschaft zur Förderung der angewandten Forschung e.V. | CORDIS-951813 | Better Factory will provide methodology for Manufacturing SMEs to collaborate with Artists to develop new and personalized products. At the same time Better Factory will provide technology for SMEs to become fully connected cyber-physical-systems, transforming them into Lean-Agile production facilities capable of manufacturing new and personalized products alongside existing products. Main results: -An Advance Production Planning and Scheduling (APPS) system which can be deployed on a free and open IoT platform at 10% of the cost in 50% less time. APPS will automatically reconfigure the collaborative robots considering the individuality and gender of worker, and will also reduce 10% assets, 25% area, 30% resources, 35% logistics, 40% machines and tools and workplaces, resulting in 13% cost reduction, 15% production increase and 30% time to market. -A Marketplace, a one-stop-shop, where Manufacturing SMEs can buy services from Technology suppliers, Artists, CCs, training providers and financial brokers. -A portfolio of 16 cross-border Application Experiments by 48 SMEs selected through 2 competitive Open Calls, that will test APPS, SME+Artis collaboration and other services, and leveraging 11M€ of public and private funding becoming success stories. -Services, including Technical, Business and Art mentors, infrastructure, training and access to finance. Better Factory network consists of 28 members. 18 DIHs (10 CCs, 8 industry associations), 6 Technology suppliers and 4 service providers for marketing, access to finance, FSTP management and legal framework. Partners are currently engaged in I4MS-Go, DIH², HORSE, L4MS, MIDIH, AMABLE, BOWI, SHOP4CF. Better Factory covers 16 EU countries, 17 regions with 10 of them from EU-13. Better Factory will demonstrate that public funded research can help manufacturing SMEs & Mid-Caps achieve digital excellence and global competitiveness through Lean-Agile production for the manufacturing of new and personalized products. | H2020-EU.2.1.1. / 2.1.1 LEIT - ICT | 0business_rnd_innovation
|
gen_6ea954a358ce3a7322ca5292fe89c069 | Graphene Flagship 2D Experimental Pilot Line | European Commission | Airbus Defence and Space; AVANZARE INNOVACION TECNOLOGICA SL; NAWATECHNOLOGIES; Imec; Delft University of Technology; Technion - Israel Institute of Technology; Università di Pisa; BEDIMENSIONAL SPA | CORDIS-952792 | The 2D Experimental Pilot Line (2D-EPL) project will establish a European ecosystem for prototype production of Graphene and Related Materials (GRM) based electronics, photonics and sensors. The project will cover the whole value chain including tool manufacturers, chemical and material providers and pilot lines to offer prototyping services to companies, research centers and academics. The 2D-EPL targets to the adoption of GRM integration by commercial semiconductor foundries and integrated device manufacturers through technology transfer and licensing. The project is built on two pillars. In Pillar 1, the 2D-EPL will offer prototyping services for 150 and 200 mm wafers, based on the current state of the art graphene device manufacturing and integration techniques. This will ensure external users and customers are served by the 2D-EPL early in the project and guarantees the inclusion of their input in the development of the final processes by providing the specifications on required device layouts, materials and device performances. In Pillar 2, the consortium will develop a fully automated process flow on 200 and 300 mm wafers, including the growth and vacuum transfer of single crystalline graphene and TMDCs. The knowledge gained in Pillar 2 will be transferred to Pillar 1 to continuously improve the baseline process provided by the 2D-EPL. To ensure sustainability of the 2D-EPL service after the project duration, integration with EUROPRACTICE consortium will be prepared. It provides for the European actors a platform to develop smart integrated systems, from advanced prototype design to small volume production. In addition, for the efficiency of the industrial exploitation, an Industrial Advisory Board consisting mainly of leading European semiconductor manufacturers and foundries will closely track and advise the progress of the 2D-EPL. This approach will enable European players to take the lead in this emerging field of technology. | H2020-EU.1.2. / 1.2 Future and Emerging Technologies (FET) | 7research_infrastructure
|
gen_ddc2f381b18a6e0aa092cf4e10358f22 | OPEN INNOVATION TEST BED FOR DEVELOPING SAFE NANO-ENABLED BIO-BASED MATERIALS AND POLYMER BIONANOCOMPOSITES FOR MULTIFUNCTIONAL AND NEW ADVANCED APPLICATIONS | European Commission | Wrocław University of Technology | CORDIS-953206 | To succeed in the ambitious objective of achieving a climate-neutral EU by 2050 the nano-enabled bio-based materials sector shall respond to some specific risks in the short term. BIONANOPOLYS will address the following risks and challenges in order to strengthen the circularity of nano-enabled bio-based materials in the economy: ›Acceptance of new technology by the market. ›Seasonal sustainability of feedstocks. ›Price competition and market. ›Other risks: The existing legislation is costly in particular for small companies. For example, nano-ecotoxicology related to the use of nano-enabled materials in industry and/or food contact. Considering these challenges, BIONONAPOLYS Open Innovation Test Bed will improve technologies, processes, considering different feedstock. BIONANOPOLYS offers: ›PILOT LINES: Cutting edge technology upgraded at TRL 7 with the objetive to produce nanoenabled biobased materials with multifunctional properties to be dispersed in cellulose and polymeric matrices assuring the best dispersion and the robustness of the final properties. Developed materials will be validated in application such as packaging, cosmetic, medical, foam, nonwoven, coating, 3D printing, textiles and cellulose-paper. ›PRIMARY RAW MATERIALS FROM DIFFERENT FEEDSTOCKS: BIONANOPOLYS will use the most relevant feedstock in Europe to obtain bio-based nano-enabled composites. ›HIGH VOLUME APPLICATIONS: BIONANOPOLYS offer solutions for more than the 50% of the applications that are currently using bio-based materials. ›COMPLEMENTARY SERVICES: BIONANOPOLYS will offer to the industry a wide variety of services for the market uptake of a new bio-based nano-enabled products, such as safety protocols for bio-based nano-enabled materials, training for staff specialization, standardisation, business modelling, access to follow-on finance or IPR protection as a crucial mean of ensuring the capitalisation on the investments made by our stakeholders and other investors. | H2020-EU.2.1.3. / 2.1.3 LEIT - Advanced materials | 6project_grants_public
|
gen_a7a5bd5a8a405b52cc1ea34ea2518627 | CREATing cOmmunity eneRgy Systems | European Commission | Autoritat Portuària de Barcelona (Port de Barcelona) | CORDIS-957815 | CREATORS enables local initiators to create and operate advanced Community Energy Systems (CES) by supporting technical, financial and social processes. With the sector moving beyond inventor-lead pilots, local CES initiators lack the capacity for high-quality simulation, business modelling and automated operations that are required in communities with a range of vectors, 1000s of mixed members, and balancing/ trading that requires controls in milliseconds. Leading engineering firms Cordeel and COMSA work with specialists in simulation and energy trading (i.LECO), emulation for digital twins (Typhoon HIL), and financing (EnergyPro) to develop services that enable local professionals to apply state of the art energy system technologies. These applications and integrated packages will mature from TRL5-6 to TRL7-8 and eventually be offered as ´CES-as-a-Service´. The services will deliver 60% preparation and operational costs reductions, ensuring 99,95% uptime, 20-35% CAPEX reduction, and up to 40% additional incomes. The results are 5-10% local energy price reduction (below €0,18kWh) in systems covering all vectors, with 10³ - 10⁴ participants. The approach creates 2 fte jobs in each CES, whilst for partners remote services could reach 10% the system turnover, in what is a high growth market. In standardizing simulation and assessment tools in close collaboration with local stakeholders (30 LoS), the BRIDGE initiative and lenders (industry-lead Investor Confidence Protocols), CREATORS significantly advances commercial readiness (CRI3). The applications will be developed in 4 sites (Belgium, Spain, Slovenia, Estonia), and replicated in another 6 (the Netherlands, Bulgaria, France, Spain). The pilots mix vectors, participants and business models, covering in total >2000 households, >500SMEs and >5 industrial sites. Ten more prospective CES will be supported in feasibility studies through a competitive process, which also aims to prepare for commercial market entry. | H2020-EU.3.3. / 3.3 Societal Challenges - Energy | 0business_rnd_innovation
|
gen_52f286fb34ebbffc92672fb1374454f2 | Prototype system for a Copernicus CO2 service | European Commission | Cyprus Institute; KAMINSKI THOMAS HERBERT | CORDIS-958927 | To support EU countries in assessing their progress for reaching their targets agreed in the Paris Agreement, the European Commission has clearly stated that a way to monitor anthropogenic CO2 emissions is needed. Such a capacity would deliver consistent and reliable information to support policy- and decision-making processes. To maintain Europe’s independence in this domain, it is imperative that the EU establishes an observation-based operational anthropogenic CO2 emissions Monitoring and Verification Support (MVS) capacity as part of its Copernicus programme. The CoCO2 Coordination and Support Action is intended as a continuation of the CO2 Human Emissions (CHE) project, led by ECMWF. In the Work Programme, ECMWF is identified as the predefined beneficiary tasked to further develop the prototype system for the foreseen MVS capacity together with partners principally based on the CHE consortium. In addition, ECMWF will continue some of the work initiated in the VERIFY project as well. The main objective of CoCO2 is to perform R&D activities identified as a need in the CHE project and strongly recommended by the European Commission's CO2 monitoring Task Force. The activities shall sustain the development of a European capacity for monitoring anthropogenic CO2 emissions. The activities will address all components of the system, such as atmospheric transport models, re-analysis, data assimilation techniques, bottom-up estimation, in-situ networks and ancillary measurements needed to address the attribution of CO2 emissions. The aim is to have prototype systems at the required spatial scales ready by the end of the project as input for the foreseen Copernicus CO2 service element. | H2020-EU.2.1.6. / 2.1.6 LEIT - Space | 6project_grants_public
|
gen_f7276dc9fd2cf9e4f66f785415ce63f7 | Investigating Immunosuppression in Beta-catenin-mutated Hepatocellular Carcinoma for Improved Precision Medicine Therapeutics | NIH | UNIVERSITY OF PITTSBURGH AT PITTSBURGH | 1F30CA284540-01 | PROJECT SUMMARY/ABSTRACT Hepatocellular carcinoma (HCC) is the 6th leading cause of cancer-associated mortality in the United States, and is rising due to chronic liver disease and its associated sequalae. Currently, the response rates to current therapeutic paradigms consisting of immune checkpoint inhibitors (ICIs) remain low, and there exist an urgent need for novel combinatorial therapies to improve patient mortality. Lack of response to current ICIs is mainly due to a poor understanding of the tumor immune microenvironment (TIME) and how various HCC driver mutations lead to specific immune phenotypes. Additionally, there currently exist no biomarker-driven therapeutics for patient treatment stratification. ꞵ-catenin-active (encoded by mutated CTNNB1 oncogene) HCCs represent approximately 26-35% of HCCs and respond poorly to ICIs due to ꞵ-catenin driving an immunosuppressive TIME and limiting the effector function of lymphocytes important for anti-tumor immunity. We have developed novel ꞵ-catenin-mutated HCC mouse models where mutant CTNNB1 is co-expressed with either the proto-oncogene MET (ꞵ-catenin/hMet) or nuclear factor erythroid 2–related factor 2 (Nrf2) (ꞵ- catenin/Nrf2). These models represent 11% and 10% of all clinical HCC cases, respectively. Our preliminary studies demonstrate that ꞵ-catenin potentiates tumorigenesis in ꞵ-catenin-mutated HCC, and that directly targeting ꞵ-catenin promotes an inflammatory response driving anti-tumor immunity. Based on these observations, our overarching hypothesis is that ꞵ-catenin actively suppresses the adaptive immune response in the TIME and targeting ꞵ-catenin or its downstream immunomodulatory factors may improve susceptibility to ICIs. To investigate, I propose the following specific aims, which will uncover novel mechanisms of ꞵ-catenin signaling in the HCC TIME, aimed at developing precision medicine therapeutics. Specific Aim 1: We will determine the immune cells activated following ꞵ-catenin inhibition, and investigate whether there is in vivo synergy combining ꞵ-catenin inhibition and ICIs through single-cell RNA-sequencing (scRNA-seq) and multiplex immunohistochemistry. Thus, we will identify mechanisms of immunosuppression caused by ꞵ-catenin activation in ꞵ-catenin-mutated HCC. Specific Aim 2: Based on our preliminary data showing interferon regulatory factor- 2 (IRF2) repression in ꞵ-catenin-mutated HCC, we hypothesize that ꞵ-catenin-mutated HCCs may be sensitized to ICIs, or even show spontaneous tumor regression, upon re-expression of IRF2 as a result of enhanced immune response. We will use synthetic biology approaches to selectively induce IRF2 expression at various timepoints in tumorigenesis and monitor tumor burden. We will then use scRNA-seq on the lymphoid population to identify cell types and states regulated by IRF2, and test combination of IFNg (which induces IRF2) + ICI as a therapeutic modality. Contribution to Training: This proposal combines rigorous research training in liver cancer biology, immuno-oncology, and advanced bioinformatic analyses with an excellent clinical education, to aid my development as a future academic physician-scientist at the forefront of immune dysfunction in cancer. PROJECT NARRATIVE Hepatocellular carcinoma (HCC) is increasing in incidence due to the sequalae of chronic liver disease, with no significant recent improvement in patient survival due to a lack of biomarker-driven therapeutics. ꞵ-catenin- activation (mutated CTNNB1 oncogene) represents a molecular subset of HCC cases which are resistant to current immunotherapies. This proposal will investigate mechanisms of ꞵ-catenin activation driving immunosuppression in the tumor immune microenvironment, with our results paving the way for precision medicine therapeutics for ꞵ-catenin-mutated HCC. | Training, Individual | 1fellowships_scholarships
|
gen_326e53e533739f06ddc08fbacb22f50b | Elucidating the distinct roles of T cell-polarized microglia in glioblastoma suppression and progression | NIH | SALK INSTITUTE FOR BIOLOGICAL STUDIES | 1F31CA284773-01 | Project Summary/Abstract Glioblastoma is a grade IV diffuse astrocytoma, the deadliest and most common form of adult brain cancer. Standard of care extends survival by approximately 1-18 months, with the poorest benefits being seen by elderly patients (>70yrs). New forms of immune-based therapies, including immune checkpoint inhibitors (ICI), may turn the corner in treatments for primary and recurrent glioblastoma. Unfortunately, no clinical trial so far has shown major benefits in either survival or immune engagement for these patients. Recent findings suggest that gliomas harbor multiple and intertwined cellular sources of immune suppression that dampen ICI-initiated responses. Thus, one solution may be to not only enhance effector T cells by blocking checkpoints such as CTLA-4 and PD- 1, but to also target the immune suppressive niches in glioblastoma, the largest of which is comprised of glioma- associated microglia and macrophages (GAMs). In fact, GAMs are a highly attractive target and have been depleted in pre-clinical and clinical studies via CSF1R inhibition (PLX3397). This approach, however, yielded mixed responses in models and no response in patients. Another path may be to reprogram GAMs, but we lack insights into the pathways that promote anti-tumor GAMs. Therefore, identifying the cellular and molecular regulators of pro- and anti-tumor GAM states is the next step in unlocking new therapeutic avenues. Recent work by the Kaech lab showed that CTLA-4 blockade in orthotopic mouse models of glioblastoma reduced regulatory T cell (Treg) infiltration, increased ‘helper’ Th1 cell infiltration, and microglia exposed to Th1 cell-derived IFNg were reprogrammed into an antigen presenting (MHCII+), tumor-phagocytosing (AXL+/MER+) state; in concert, these effects significantly increased survival. This proposal will investigate how GAMs, especially the brain resident microglia, acquire and maintain distinct functional states with the hypothesis that Treg-specific signaling sustains tumor-promoting GAMs during glioblastoma progression while Th1 T cells induce tumor-killing GAMs during an effective ICI-initiated response. Two specific aims are proposed to interrogate this hypothesis. The first aim will employ single-cell spatial transcriptomics to address whether Tregs and Th1 cells are extrinsic regulators of GAM states through direct contact and/or secretory signaling, and whether these interaction axes exist in human glioblastoma. The second aim will define the intrinsic AXL/MER and related pathways regulating GAM state ‘switching’. In summary, this work will better inform GAM-targeting interventions by defining how infiltrating T cells and GAM-intrinsic signaling pathways coordinate the dynamic biology underlying pro- and anti-tumor GAM states. This application outlines the applicant’s proposed training plan, which includes diverse and multidisciplinary research mentorship, training in cutting-edge and advanced techniques, and development of broader scientific skills such as collaboration and effective communication. The research and training outlined in this proposal will prepare the applicant to conduct innovative, rigorous, and impactful research. Project Narrative Glioblastoma is the most common adult brain cancer and has remained incurable since it was first identified over two centuries ago. A central reason for this failure in treatment lies in the heterogenous and immunosuppressive nature of these malignancies, and its ability to evade the immune system from destruction. This proposal will identify how microglia and macrophages, the largest non-tumor component of the microenvironment, can adopt opposing “tumor killing/tumor promoting” activation states and how manipulation of these different states may redirect progressing glioblastoma toward regression. | Training, Individual | 1fellowships_scholarships
|
gen_ca4d06d4aa6040f5ea34a0636ab0995f | JEOL 2100PLUS(CR) | NIH | UNIVERSITY OF GEORGIA | 1S10OD034282-01 | Project Summary/Abstract Cryogenic Transmission Electron Microscopy (cryoTEM) has emerged as a powerful approach to acquiring structural information from proteins, subcellular organelles, and other biomacromolecules and their assemblies. This proposal seeks funding to bring cryoTEM capabilities to the University of Georgia for the purpose of facilitating NIH-supported research related to cell organelle biogenesis, the biochemistry of metabolism and gene expression, the mechanisms of diverse human diseases and disorders, antibody therapeutics, antivirals, treatments for infectious diseases, and fundamental structural and cellular biology. The proposed equipment includes a cryo-capable, 200 kV transmission electron microscope (JEOL 2100PLUS) with a direct electron detection device (Direct Electron DE16ER camera) and the essential equipment needed for sample vitrification and handling (a Leica EM GP2 automatic plunge freezer, and a Gatan Elsa cryo sample holder with turbo benchtop pumping station). This multipurpose cryoTEM system will support the needs of NIH-funded investigators at the University of Georgia (UGA) for (1) the preparation and screening of vitrified samples; (2) data collection for single particle analysis, tomographic reconstructions, and micro-electron diffraction; and (3) improved conventional TEM imaging. This equipment will be installed at the Georgia Electron Microscopy (GEM) core facility in custom-designed laboratory space, and it will be operated and maintained by GEM’s staff. By establishing campus-level access to cryoTEM instrumentation, services, expertise, and hands-on training, this project will enable numerous biomedical researchers to incorporate cryoTEM methods into their research programs. UGA’s vibrant, NIH-supported research groups include five major users of cryoTEM, eight minor users of cryoTEM, and additional investigators who will be future cryoTEM practitioners. Project Narrative Cryo-transmission electron microscopy has emerged as a powerful technique for acquiring key structural information from proteins, subcellular organelles, and other biomacromolecules and their assemblies. This proposal seeks funding to bring cryo-electron microscopy capabilities to the University of Georgia for the purpose of facilitating NIH-supported research progress by producing new knowledge related to cell organelle biogenesis, the biochemistry of metabolism and gene expression, and the mechanisms of diverse human diseases and disorders. These projects have strong relationships to public health priorities, specifically by developing targets relevant to respiratory diseases (e.g., RSV, hMPV, influenza), infectious diseases (e.g., malaria, H. pylori), and neurodegenerative processes (e.g., Parkinson’s and Alzheimer’s diseases) through structure-based drug and vaccine candidate design. | Other Research-Related | 7research_infrastructure
|
gen_a16713f8fdaf11a2ee8ad64f35a0d8b5 | NICHD SERVICES: FIC LOGISTICS SUPPORT | NIH | Unknown | 75N94023C00019-0-9999-1 | NICHD SERVICES: FIC LOGISTICS SUPPORT | R and D Contracts | 5out_of_scope
|
gen_db6e347d0d24b9b1e809cda492e9dba8 | Targeting a Novel Pocket on ITGAV | NIH | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 5K00CA274649-04 | Project Summary. Cancer deaths remain at an all-time high in the United States leaving an urgent clinical need to develop novel therapeutic strategies to help patients. The lack of effective treatments is in part due to underlying complexities in cancer that current scientific approaches are just beginning to uncover. Technological advances are rapidly changing the landscape of scientific discovery; for example, the combination of mathematical modeling in tandem with laboratory based validation leading to better combinational therapies to treat cancer. For this reason, I propose training in both with the F99/K00 Predoctoral to Postdoctoral Fellow Transition Award. For the F99 phase, the dissertation research, I will focus on laboratory based research skills to identify and propose a novel therapeutic to treat cancers. In a high level CRISPR screen targeting about 580 genes on the cell surface we found that Integrin Alpha V (ITGAV) is essential for the survival of solid tumors (colon, pancreatic, and breast cancer). To validate ITGAV as the most essential integrin we designed a second layer screen targeting all 26 integrins and found that ITGAV and Integrin Beta 5 (ITGB5) are the only essential integrins in solid tumors. Interestingly, integrins must for an obligate heterodimer between an alpha and a beta subunit of which ITGAV and ITGB5 are one of the known 24. As the more essential pair, ITGAV was probed with a high-density CRISPR tiling scan and we found a small pocket to be essential for ITGAV function and it was amendable to small molecule binding. A structure based analysis found a loop structure of the beta pair of ITGAV interacts with the discovered pocket, leading to our hypothesis that the pocket is essential for the heterodimer stability between ITGAV and its beta pair. Indeed, from a high-throughput screen of 500 small molecules we found one compound that appears to bind in our pocket and disrupt the heterodimer between ITGAV and ITGB5. Further validation of this potential will be the remaining work to be done for the dissertation research and upon completion, will fill an unmet clinical need since no there no FDA approved drugs targeting integrins approved for cancer indications. To further advance the potential to treat cancer I plan to use mathematical modeling approaches to identify novel therapeutic strategies by understanding the complexities of cancer signaling during the K00 phase, the proposed postdoctoral work. To study complex cancer signaling, in collaboration with Dr. Pirrotte, we generated kinase activity scores in cells where ITGAV was knocked out. With this data we can model the effects of signaling as it relates to measurable changes in the cancer cells. Specifically, we will study cell cycle control, which is inhibited with ITGAV loss. Additionally, we can model known inhibitors to common signaling cascades as novel combinational therapeutic strategies. To confirm our model, I will use laboratory based skill developed during the F99 phase. Overall with the training with the F99/K00 award I will gain skills to be able to build mathematical models to study cancer and validate those models with laboratory based skills. This will allow me to become and independent research and leading scientist in translational research. Project Narrative The proposed research aims to fill an unmet clinical need in treating aggressive cancers such as colon, pancreatic, and breast. We found that Integrin Alpha V (ITGAV) is necessary for the survival of these cancers and that a novel pocket on its structure can be targeted with a drug. Additionally, we will investigate the complex signaling controlled by ITGAV to propose combinational therapies and create new therapeutic strategies to treat these cancers. | Other Research-Related | 1fellowships_scholarships
|
gen_481b8e2ba6e9959e8921ee76b8a6b111 | ADS BPA TASK ORDER 2 PUBLIC WEBSITE DEVELOPMENT AND MAINTENANCE | NIH | BOOZ ALLEN HAMILTON | 92023A02592023F00002-0-0-1 | Not available | R and D Contracts | 0business_rnd_innovation
|
gen_4b07c8893d6634e6bf614e3e346a13b5 | Interventions that Address Structural Racism to Reduce Kidney Health Disparities Research Coordinating Center | NIH | DUKE UNIVERSITY | 5U24DK137631-02 | PROJECT ABSTRACT Recognizing the significant impact of structural racism on kidney health in minority populations, the NIH is creating a new Consortium focused on Interventions that Address Structural Racism to Reduce Kidney Health Disparities. The Consortium will bring together research teams from six Intervention Sites to conduct community-engaged intervention studies to address structural racism and reduce disparities across the spectrum of kidney health and disease. We propose to serve as the Research Coordinating Center (RCC) for the Consortium. The Duke RCC will leverage extensive institutional resources and expertise at Duke University to provide administrative leadership and research coordination to ensure seamless operations of the Consortium and successful conduct of Consortium studies; support rigorous data collection, data management, and data analysis for Consortium studies; and foster research collaboration, capacity-building, and workforce diversification in kidney health equity research. Three closely integrated cores will lead the core activities of the RCC. The Administrative and Coordination Core will provide administrative, operational, and logistical support to the Consortium, including coordinating meetings, developing a secure web-based communications and collaboration platform, supporting program management and regulatory submissions, administering an opportunity pool for ancillary studies, and continually evaluating and enhancing Consortium operations. The Data Management and Analysis Core will contribute to the final design of Consortium studies, provide data monitoring for multi-site Consortium studies, and support statistical analysis for multi-site Consortium studies and pooled analyses of common data elements across the Consortium. The Collaboration and Community Engagement Core will foster a vibrant and collaborative research community within and beyond the Consortium by facilitating discussion at Consortium meetings and workshops, supporting dissemination of Consortium results to the broader research and lay communities, integrating selected NIH career development awardees in relevant Consortium activities, and exposing early-career trainees from underrepresented groups to kidney- focused structural racism scholarly work in order to successfully implement health equity research and interventions. Together, the multidisciplinary RCC team will ensure the successful completion of multiple intervention trials targeting disparities in kidney health and build a diverse and sustainable community of researchers and community partners focused on improving kidney health in marginalized populations. PROJECT NARRATIVE Structural racism is an important contributor to disparities in kidney disease. The proposed research coordinating center will support a research network and multiple clinical trials focused on addressing structural racism to reduce disparities in kidney health and disease. | Other Research-Related | 6project_grants_public
|
gen_50c67c4d5105eefe49fcb6b60f9eeb41 | TRANS-OMICS FOR PRECISION MEDICINE (TOPMED) INFORMATICS RESEARCH CENTER (IRC) | NIH | UNIVERSITY OF MICHIGAN AT ANN ARBOR | 268201800002I-0-759202300001-1 | NHLBI's Trans-Omics for Precision Medicine (TOPMed) program started in 2014 as the flagship program supporting the development of precision medicine for heart, lung, blood diseases and sleep disorders. The main goal is to generate a large volume of genomics data that have sufficient statistical power for scientific discovery. The data are generated and processed first in TOPMed before being uploaded to external databases, database of Genotypes and Phenotypes (dbGaP) and BioData Catalyst (BDC) for researchers to access. In 2016, under TOPMed program, NHLBI funded nine (9) Centralized Omics Resource (CORE) centers that have generated approximately 200,000 whole genome sequencing and multi-omics data. As TOPMed enters its next phase TOPMed2.0 focusing on functional genomics and disease mechanism, the CORE needs to be upgraded to CORE 2.0 generating more functional genomics data, including omics data at single-cell resolution. CORE 2.0 needs to generate a large volume of functional genomics data and is in need of contractors that can provide a high capability of generating omics data. | R and D Contracts | 7research_infrastructure
|
gen_4f2db9b0e3b7f50c316fdd879b28a156 | Investigating the Critical Role of Glia In Peripheral Organ Development and Physiology | NIH | UNIVERSITY OF NOTRE DAME | 1F32HL165966-01A1 | Project Summary Organs of the human body rely on complex integration of multiple neuronal circuits in order to maintain homeostasis. For example, the heart must respond to internal and external stimuli and produce sufficient blood flow to meet environmental demands. Glia play critical roles to support nervous system function but are also indispensable for establishment of appropriate circuit structure and physiology. Our lab recently identified a cell type in the heart with many similarities to astroglia populations found elsewhere in the body. This cell type, which we termed cardiac nexus glia, is present as the heart is being formed and is critical for establishment of heart rhythm. Ablation of these glia causes cardiac arrhythmia and ventricular fibrillation, both serious physiological conditions. This project uses the zebrafish animal model to investigate the developmental ontogeny and morphological characteristics of cardiac nexus glia in the developing hearts of living animals (Aim 1). Additionally, it probes the functional relationship between these glia and cardiomyocytes and their roles in modulating heart rate and rhythm (Aim 2). The results of these experiments will contribute crucial detail to our understanding of the multi-faceted roles of glia in the peripheral nervous system and provide important and specific insight about cardiac nexus glia function in heart development and disease. This research will be undertaken in a supportive and collaborative laboratory environment within the Biological Sciences Department at Notre Dame University. It will rely on expertise from staff of the Center for Zebrafish Research and the Integrated Imaging Facility. In addition to the development of bench skills and technical expertise inherent to this project, the applicant will also hone teaching, mentoring, and management skills that will be critical for her future success as a PI running her own research group at a primarily undergraduate institution. Project Narrative Current understanding of the development and function of the peripheral nervous system is almost entirely neuron-centric and little attention has been given to the important contributions of glial cell types. This proposal aims to rectify this gap in knowledge by investigating a glial population in the developing heart that actively modulates cardiac function. A better understanding of glia supports a more complete model of neural control over peripheral physiology and pathology. | Training, Individual | 6project_grants_public
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.