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Histopathology of the thyroid in amiodarone-induced hypothyroidism.
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Drug-induced hypersensitivity syndrome (DIHS) is one of the most severe drug adverse reactions, with characteristic biphasic symptoms.
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Our case reminds the clinicians that the adverse and proarrhythmic effects of dofetilide can occur due to changes in the arrhythmic substrate during acute severe ischemia.
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We describe the case of a premature baby who developed a rapidly expanding aneurysm of the descending thoracic aorta, secondary to a highly placed infected umbilical catheter.
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Methotrexate-induced papular eruption following treatment of psoriasis.
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Hepatic portal sclerosis (HPS) alone was observed in 1 patient, nodular regenerative hyperplasia (NRH) alone in 2 patients and combined HPS/NRH in 3 patients.
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Bronchoscopy guided transbronchial lung biopsy revealed interstitial thickening and type II pneumocyte activation, compatible with interstitial pneumonitis.
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Despite severe thyrotoxicosis, combined IFN-alpha and ribavirin therapy was continued and radioiodine treatment was considered for Graves' disease.
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A syndrome of microangiopathic hemolytic anemia, renal impairment, and pulmonary edema in chemotherapy-treated patients with adenocarcinoma.
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After discontinuation of the treatment, gradual decline of bone mineral density at lumbar and femoral sites was detected with serial DEXA measurements.
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In this report, we assess the possibility that exposure of the angle-supported AC IOL haptics caused the endophthalmitis.
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We conclude that (a) cyclophosphamide is a human teratogen, (b) a distinct phenotype exists, and (c) the safety of CP in pregnancy is in serious question.
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Other laboratory studies, including urine pH, anion gap, titratable acidity, and bicarbonate, showed a distal tubular acidification defect.
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After switching to a barbiturate-free schedule, his condition continued to be unstable for more than 21 MPB half-lives (approx. 30 days) and did not stabilize until MPB-metabolites dropped below their urinary detection limit.
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This happened despite a very short course of therapy in two patients.
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The authors propose that differential involvement of dopamine systems may account for the transition from akathisia to tardive dyskinesia.
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However, thin conjunctiva is susceptible to mechanical injury and is difficult to repair with suturing, especially when the point of leakage is close to the scleral flap.
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After both patients gave informed consent, an uneventful intravitreal injection of 1.25 mg Avastin was performed in the left eyes.
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Pretreatment best-corrected visual acuities ranged from 20/40 to 20/400 (mean, 20/70 using Snellen fractions) and improved two to eight (mean, five) Snellen lines, to a range of 20/20 to 20/50 (mean, 20/25).
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Veno-occlusive disease of the liver after lung transplantation.
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Bilateral acoustic (VIII) nerve palsy in this patient was most likely a manifestation of vincristine neurotoxicity.
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A rare case of anterior chest closure only with omental flap after devastating mediastinitis: case report.
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Patients stabilized on glyburide who are started on a fluoroquinolone should have their glucose levels monitored closely.
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When retested 3 months later, at which time the serum T4 was 5.5 micrograms/dl, the patient was somewhat less hypothyroid and there was an exaggerated TSH response to exogenous TRH, indicating recovery of pituitary TSH reserve.
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Bilateral acoustic (VIII) nerve palsy in this patient was most likely a manifestation of vincristine neurotoxicity.
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Although adverse reactions to protamine are reported infrequently and are usually mild, we recently observed the first fatal case of type I anaphylaxis resulting from protamine.
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All target symptoms disappeared in the patients after an average of (mean+/-S.D.) 24.5+/-18.1 days.
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We believe this to be the first culture-proven case of L. micdadei PVE reported in the literature.
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Life threatening laryngeal toxicity following treatment with combined chemoradiotherapy for nasopharyngeal cancer: a case report with review of the literature.
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All four patients had pericardial abnormalities on echocardiography prior to receiving gemcitabine.
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DESIGN: Case report.
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These data indicated that infliximab possibly triggered production of granulocyte and neutrophil autoantibodies with resultant autoimmune agranulocytosis.
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Bortezomib-induced paralytic ileus is a potential gastrointestinal side effect of this first-in-class anticancer proteasome inhibitor.
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We report a case of a patient with pulmonary hypertension and undifferentiated connective tissue disease who, after 2 months of treatment with epoprostenol, presented with rapidly progressive erythema, scaling, nausea and vomiting, and fever.
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The temporal course of the porphyrin abnormality suggested that cyclophosphamide was the pathogenic agent, and symptoms regressed after cessation of this drug with continued administration of cisplatin.
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Two patients developed hypersensitivity to nitrosourea compounds.
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Aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension in a patient treated with trimethoprim-sulfamethoxazole.
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In this report, one patient who developed gangrene after bleomycin and vincristine/vinblastine chemotherapy for AIDS-related Kaposi's sarcoma and another HIV-infected patient who exhibited symptoms of severe Raynaud's phenomenon related to the same regimen are presented.
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There are, however, obligations on the dentist to ensure the accuracy of information the patient gives and to ensure that patients whom they believe are at risk follow their advice.
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In patients who show abnormal liver function tests, the immediate discontinuation of gliclazide is recommended.
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Comorbid alcohol dependence is common in patients with schizophrenia and is associated with a variety of serious adverse consequences.
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The present report illustrates a rare case of refractory akathisia after interferon-alpha treatment and also that levodopa treatment would be theoretically and practically useful in reducing the neurotoxicity associated with interferon-alpha.
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This is the first case, to our knowledge, of onset of prolonged infliximab-induced lupus.
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The patient was discharged with a diagnosis of HCV-related active chronic hepatitis, skin porphyria, and type 2 diabetes.
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Thiazide-induced lichenoid photosensitivity.
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CASE SUMMARY: A 37-year-old Hispanic man with diabetes mellitus, ethanol abuse, and recent crank use developed a venous thrombosis and possible pulmonary embolism, followed by acute liver and renal failure requiring continuous veno-venous hemofiltration.
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Because of the presence of hemolysis, the patient underwent testing for glucose-6-phosphate dehydrogenase (G6PD) deficiency, for which he tested positive.
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RESULTS: The number of days each patient received mecamylamine varied from 8 days to 550 days; with nine patients more than 200 days, six patients from 100-200 days, five patients for 50-100 days, and four patients 0-50 days.
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A case of high-grade endometrial stromal sarcoma, confined into an intrauterine polypoid growth, in a woman with a history of breast cancer who was treated with adjuvant tamoxifen.
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CONTEXT: Acute pancreatitis has been reported in a few cases treated with macrolides or glucocorticoids.
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The potential for progressive brain injury and subsequent disability related to intraventricular IL-2 therapy is discussed.
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Three days after administration began, serum CPK levels had become markedly elevated to 10,897 mg/dl and myoglobinuria was detected (1,800 ng/dl), suggesting the presence of rhabdomyolysis.
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Avascular necrosis (or osteonecrosis) is a very rare extraintestinal osseous complication that may occur in Crohn's disease, independent of previously reported risk factors, including corticosteroids or parenteral nutrition with lipid emulsions.
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Using a ventricular reservoir to instill amphotericin B.
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Forty-eight hours later a commercially available cylindrical diffusing laser fiber was inserted into an 8F biliary catheter equipped with a 0.038 inch side-hole at its distal tip.
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On March 13 the patient was again admitted for worsening CHF and was started on continuous dobutamine infusion.
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A 36-year-old man being treated with cisplatinum, vinblastine, and bleomycin for testicular carcinoma developed a dense left homonymous hemianopsia, encephalopathy, and a partial nondominant parietal lobe syndrome.
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Until today, many kinds of complications have been reported in the literature.
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Clinicians should be aware of the signs and symptoms of neurotoxicity during treatment, as well as predisposing factors that put patients receiving methotrexate at risk for neurotoxic effects.
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The possibility of a recrudescence of a persisting infection was rejected.
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Intravenous ribavirin was obtained and administered for 5 days without success; the patient's mental status deteriorated rapidly and she died on day 69 post-transplant.
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Fatal pulmonary fibrosis following 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy.
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Tolerance to phenelzine and subsequent refractory depression: three cases.
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We assume that the clinical picture was mainly dictated by flecainide intoxication.
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RESULTS: Visual acuity was reduced to 1/50 and 0.3.
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Soon after introduction of insulin therapy, she developed severe anasarca, including marked peripheral oedema, ascites and pleural effusion.
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DISCUSSION: SIADH has been reported as a complication of treatment with vinca alkaloids.
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Clinical features include an acute, symmetrically progressive polyneuropathy, focal or generalized myokymia and a tendency for initial neurological deterioration followed by improvement, after cessation of chrysotherapy.
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There was initial clinical deterioration while in vitro data indicating that the organism was sensitive to vancomycin with a minimum inhibitory concentration of 0.5 micrograms/ml.
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With the extensive use of platinum-based chemotherapy regimens, either alone or in combination with radiation therapy in the management of gynecological malignancies, this uncommon complication should be kept in mind for early detection and successful management.
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After returning to a normal level of greater than 100,000/mm3, the patient's platelets again dropped to 1200/mm3 with readministration of rifampin.
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Mitomycin C (MMC) is an alkylating agent that has been recently associated with the hemolytic-uremic syndrome (HUS).
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With the progression of immunoreconstitution, the lesions healed spontaneously.
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However, this mechanism may fail under certain circumstances, in particular if D2 dopamine antagonism exceeds a certain threshold.
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A third case of acquired phosphate diabetes associated with a syndrome of inappropriate secretion of antidiuretic hormone (SIADH), related to a pulmonary tuberculosis, is reported.
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This therapeutical regimen was chosen--in accordance with cardiac surgeons, cardiologists, and interventional radiologists--due to the high risk of adverse event after repeated surgery in this particular patient.
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We describe the first case of a Chinese liver transplant recipient with PVB19-induced PRCA during immunosuppressive therapy.
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This hypersensitivity response cannot be explained pathophysiologically by any mechanism.
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She died within six weeks of developing congestive heart failure coupled with liver failure due to haemosiderosis despite regular use of desferrioxamine.
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Active vitamin B12 contains cobalt in its reduced form (Co+).
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We present the case of a 67-year-old depressed woman who began treatment with citalopram.
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Hepatic uroporphyrinogen decarboxylase activity is markedly reduced in patients with this disorder.
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Two of the five patients who worsened motorically also developed encephalopathy during risperidone treatment; the encephalopathy resolved when the patients were switched to clozapine treatment.
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A diagnosis of phenytoin toxicity was made and she was treated by withdrawing the medication.
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Patients taking multiple medications may suffer from unpredictable and complex drug-drug interactions resulting in significant morbidity and mortality.
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The role of heparin therapy.
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The duration of pain was 17.8 +/- 9.3 months (mean +/- SD), and the baseline VAS score was 88.2 +/- 6.3 points.
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Wernicke encephalopathy and beriberi during total parenteral nutrition attributable to multivitamin infusion shortage.
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His serum transaminases were slightly elevated and hepatic hyperechogenicity was observed on ultrasonography.
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A female patient with HER2 positive, metastatic breast cancer presented with pulmonary infiltrates, and a plural effusion dyspnoea after several months of trastuzumab treatment.
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The outcome of 19 other children with severe aplastic anemia who received ATG was also summarized.
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In this case, unlike those previously reported, hyponatremia recurred 5 months after switching from citalopram to mirtazapine, which is believed to be a safe antidepressant.
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Medical treatment of fungal endocarditis on prosthetic valves can be successful in selected cases.
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Both colchicine and statin therapy may be associated with myopathy, which usually occurs after several months of therapy.
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Rituximab-based therapy for gemcitabine-induced hemolytic uremic syndrome in a patient with metastatic pancreatic adenocarcinoma: a case report.
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Open-lung biopsy revealed numerous lipid-laden macrophages and multinucleated foreign-body giant cells.
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Before receiving PUVA therapy one patient had been treated with topically applied thiotepa and x-ray irradiation, while in the other patient PUVA was the only treatment received except for topical corticosteroids.
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Although a lot of amiodarone-induced torsades de pointe have been published, a review of all these cases and the underlying risk-factors has never been made.
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Isoniazid induced gynaecomastia: a case report.
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It usually occurs in patients with impaired renal function or when allopurinol is prescribed with a thiazide diuretic.
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