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Seven months after continuous antitubercular treatment, the KS nodules regressed spontaneously and finally disappeared.
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A 60-year-old woman with diabetes mellitus (type 2) developed an acute icteric hepatitis-like illness 6 weeks after the initiation of gliclazide therapy.
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CONCLUSION: Lipoid pneumonia as a result of mineral oil aspiration still occurs in the pediatric population.
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MATERIALS AND METHODS: A phase II study.
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Thyrotropin concentrations and cardiac systolic time indexes during the elevation of serum CK concentrations were not consistent with hypothyroidism.
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Most of these patients presented with complex symptoms arising from a variety of pathological conditions including ischemic heart disease, myocardial infarction, cerebrovascular accident, pneumonia, and trauma.
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RESULTS: Fifteen patients (10 male) were interviewed (median age 49.5 years, range 24 to 68 years).
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The reported frequency in young children varies (1-4).
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Cardiopulmonary bypass support can be considered as a salvage therapy.
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In this study, we report on three individual patients who received BTX-B and who subsequently developed parasympathetic dysfunction of the visual system after injections of BTX-B at remote sites.
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Laboratory studies yielded substantially increased serum procollagen III levels and anticardiolipin antibodies accompanied with anti-beta(2) glycoprotein I, findings not previously described with this disorder.
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Peripheral blood count revealed pancytopenia and a bone marrow biopsy was consistent with aplasia.
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Trough whole blood tacrolimus concentrations ranged from 1.7 to 6.2 microg/L.
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While the pathogenetic and clinical relationship between the different autoimmune-dysreactive complications is still unclear, and the supporting role of the frequent immunosuppressive treatment may add significantly to these risk factors, clinicians who are engaged in the management of these patients should be aware that multiple, concurrent or subsequent disorders might occur in these subjects, and also that severe infections might be of relevant concern.
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No gastrointestinal tract or muscular abnormalities were found, and the discomfort was attributed to neuropathic pain.
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Because the cerebellar toxicity may be worsened by continuation of therapy after initial onset of symptoms, prompt termination of HDARAC is recommended.
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Trimethoprim-sulfamethoxazole, pseudomembranous colitis, and spinal cord injury.
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One patient who received clindamycin had liver biopsy findings of marked cholestasis, portal inflammation, bile duct injury and bile duct paucity (ductopenia).
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For neurologists faced with the task of treating PD patients, the available array of medications may be confusing and intimidating.
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Serum complement components and immunoglobulin levels were within normal limits, and radioallergosorbent testing gave negative results.
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Masculinization of a female fetus occurred in 5 of 39 (12.8%) exposed to norethisterone; all were cases of clitoral hypertrophy not requiring surgical treatment.
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We suggest that objective evaluation of retinal function with electrophysiological methods should be performed in patients with visual disturbance during treatment with rifabutin.
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Acute kidney injury caused by zonisamide-induced hypersensitivity syndrome.
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Gentamicin alone may be nephrotoxic and should be given with particular caution to the elderly and those with even mild kidney abnormalities.
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On day four he was noted to have complete right sided femoral and left sided lateral femoral cutaneous nerve of thigh neuropathies.
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It is generally well tolerated and significant adverse reactions occur rarely.
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Bronchiolitis obliterans organizing pneumonia (BOOP) is a rare disease, which is histopathologically defined by the presence of granulation tissue in the bronchioles, alveolar ducts and alveoli leading to plugging of the bronchiolar and alveolar lumen.
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Gold-induced aplastic anemia.
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We report 2 cases of maculopapular eruption and fever in patients infected with human immunodeficiency virus (HIV) on the 2nd day of first administration of ritonavir, a protease inhibitor.
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Graft-vs-host disease (GVHD) is a potentially treatable cause of progressive neurologic decline after bone marrow transplantation (BMT).
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The case of a premature intra-uterine growth retardation (IUGR) infant, born from caesarean section to a mother with hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome, and admitted to NICU for low birth weight is reported.
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Three of the seven subjects showed marked improvement in behaviour, with NPI scores dropping significantly over time.
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We describe a case of needle-track cutaneous seeding of hepatocellular carcinoma (HCC) after sonographically guided percutaneous ethanol injection (PEI).
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The possibility of phenytoin hypersensitivity reactions should be considered when patients receiving phenytoin have unusual symptoms, particularly fever, rash, and lymphadenopathy.
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At 13.25 years rhGH therapy was discontinued owing to frequent hypocalcemic crises; serum IGF-1 levels were persistently low in the following years (between 160 and 180 microg/l, normal range for age 250-600 microg/l).
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Based upon the observed fall of the filtration fraction, the rise in the relative clearance of 99Tc-dimercaptosuccinic acid and the increase in proteinuria, we suggest that in this case the tubules and/or interstitium are the main targets for cyclosporine A nephrotoxicity.
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Physicians should be aware of the risk of severe AIHA in CLL patients with a history of AIHA or positivation of the DAT during previous fludarabine administration, or in case of secondary fixation of complement to the red cell membrane occurring during fludarabine treatment.
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Among CNS toxicities, generalized tonic-clonic seizures have been reported in both children and adults.
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We present a 49-year-old woman with refractory myofascial pain of many years duration who developed subacromial impingement syndrome (SIS) following a series of botulinum toxin injections to the bilateral upper trapezii.
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CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.
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CONCLUSIONS: Intravitreal bevacizumab appears to be an effective tool in the immediate control of neovascularization following L-CRA for nonischaemic CRVO.
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Pneumonitis, bilateral pleural effusions, echocardiographic evidence of cardiac tamponade, and positive autoantibodies developed in a 43-year-old man, who was receiving long-term sulfasalazine therapy for chronic ulcerative colitis.
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Endoscopic application of photodynamic therapy for cholangiocarcinoma.
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Clinical and biochemical abnormalities disappeared soon after discontinuation of PTU.
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Alternaria is a very common and saprophytic fungus.
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Multicenter randomized study of two once daily regimens in the initial management of community-acquired respiratory tract infections in 163 children: azithromycin versus ceftibuten.
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Only a prospective two-arm ALL dexamethasone study at two dose levels (6 and 10 mg/m(2)/day) will clarify if indeed the higher dose of dexamethasone during induction is more effective and without unacceptable toxicity.
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The serum levels of calcium hopantenate were high in coma, and that of pantothenic acid examined in one patient was lowered.
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OBJECTIVE: Transcatheter arterial embolization (TAE) with gelatin sponge particles and iodized oil often yields poor results when used to treat unresectable multifocal hepatocellular carcinoma (HCC).
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Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.
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Previous studies have demonstrated the interaction of MTX and a variety of non-steroidal, anti-inflammatory drugs (NSAIDs) with various clinical manifestations including acute renal failure, pancytopenia, vomiting, diarrhea, elevated liver transaminases, jaundice, mucosal ulcerations, and pyrexia.
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This patient was previously well with no known cardiovascular risk factors.
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Pulmonary hypertension during lithium therapy: clinical case study.
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Pulmonary toxicity is believed to be uncommon.
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Argatroban is hepatically cleared and may be the preferred direct thrombin inhibitor in the presence of significant renal impairment, but conversely has prolonged effects in hepatic failure.
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We present two new cases, and we review 55 additional cases from the literature.
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Report of two cases of male breast cancer after prolonged estrogen treatment for prostatic carcinoma.
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The catheter failure was not visualised by plain X-ray nor by filling the pump with radio-opaque solution.
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Detection of VZV DNA in blood may be useful for early diagnosis in immunocompromised hosts who present with zoster without skin lesions.
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OBJECTIVE: Omeprazole is one of the most widely prescribed gastric antisecretory drugs.
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Second cancers including various types of hematological malignancy have been reported in patients with hairy cell leukemia treated with chemotherapy or interferon alfa.
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CONCLUSION: A review of the literature shows that this is a particularly uncommon micro-organism.
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An oncological consultation recommended 4 mg nebulised morphine and 4 mg dexamethasone in saline as treatment for the bouts of breathlessness.
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An infertile patient with amenorrhea-galactorrhea syndrome lost vision during a pregnancy occurring after Bromocryptine treatment.
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Post BMT she developed acute grade II graft-vs.-host disease (aGVHD) requiring high-dose steroids and anti-thymocyte globulin.
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Pacemaker related endocarditis is a rare potentially fatal condition, most commonly acquired during manipulation of the pacemaker system.
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After treatment with recombinant tissue plasminogen activator, the patient's hemodynamic status improved, permitting the liver transplant to be completed.
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We describe a 28-year-old man with stage IV-B Hodgkin's disease who developed an adenocarcinoma of the colon after treatment with combination chemotherapy.
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Although the enuresis ceased, she developed throbbing headaches, nausea, vomiting, paresthesia, lethargy, fatigue, and altered mental status over the next 7 days.
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DISCUSSION: Although there are several reports on extensive passage of lamotrigine into breast milk, this is the first published report of a serious adverse reaction in a breast-fed infant.
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In this article, we present a unique case of a 31-year-old woman with severe autoimmune hepatitis apparently abruptly triggered by vaccination.
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This patient developed sequential symptoms including alternative hemiparesis, dysarthria and altered consciousness 5 days after the second course of HD-MTX (8 gm/m2 by 6 h continuous infusion) with leucovorin rescue.
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The renal failure in each case was reversed by discontinuation of MP and/or by forced diuresis using albumin and furosemide.
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Open biopsy of the affected thoracic vertebrae and surrounding soft tissue were negative for neoplasia.
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These patients with limited-stage SCEC were treated at our institution with four cycles of CBDCA and VP-16, either concurrent with radiotherapy for the second two cycles (n = 2) or followed by radiotherapy after the last cycle (n = 1).
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When olanzapine was held, the signs and symptoms improved and then returned with rechallenge of olanzapine.
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Stevens-Johnson syndrome and toxic epidermal necrolysis (TEN) are mild-to-life-threatening adverse reactions that have been described after exposure to fluoroquinolones.
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Two weeks later, anemia, thrombocytopenia and progressive increase in BUN, creatinine and LDH were observed.
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The frequent use of neuroleptic drugs in the treatment of disturbed children and adolescents demands that clinicians be aware of the danger of tardive dyskinesia in this age group.
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Diazepam abuse in pregnant women on methadone maintenance.
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A 60-year-old male patient with ischemic cardiomyopathy experienced an electrical storm 1 month after implantation of an internal cardioverter-defibrillator.
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The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.
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Amifostine has been found to significantly decrease acute and chronic xerostomia but not mucositis.
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The patient developed hypovolemic shock with abdominal pain and distension and further evidence of myocardial necrosis.
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We describe two cases of sulfadiazine-induced crystalluria and renal failure in patients with acquired immunodeficiency syndrome, review the pertinent literature, and discuss the pathogenesis.
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He denied aspirin or non-steroidal anti-inflammatory drug use.
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He was successfully treated with trimethoprime-sulfamethoxazole (TMP-SMX) and meropenem without craniotomy or repeat aspirations.
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Clinicians who manage cachectic patients, particularly those with protracted diarrhoea and/or receiving anti-malarial drugs including mefloquine, should be aware of the risk of severe hypoglycaemia.
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Five other patients with previous sensitivity to methotrexate, forcing cessation of therapy, were given weekly oral methotrexate and folinic acid every day except the day of methotrexate.
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Management and successful desensitization in methotrexate-induced anaphylaxis.
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We investigated whether clozapine used as a first-line antipsychotic drug can cause TD.
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Management of iatrogenic intravitreal triamcinolone acetonide.
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Phenobarbital hepatotoxicity in an 8-month-old infant.
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In any case, from a clinical viewpoint, caution should be used when giving venlafaxine to patients with narrow-angle glaucoma, and ocular pressure must be monitored.
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One hundred and forty one cases from the literature are reviewed with special reference to patient characteristics, patient treatment, and prognosis.
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PURPOSE/OBJECTIVES: To describe the pharmacogenetic syndrome of dihydropyrimidine dehydrogenase (DPD) deficiency, which predisposes patients with cancer to potentially lethal adverse reactions following 5-fluorouracil (5-FU)-based chemotherapy.
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We describe eight episodes of reversible acute renal deterioration in five patients with ADPKD, massive renal involvement, and chronic renal insufficiency.
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We report the occurrence of spontaneous intracranial bleeding in an human immunodeficiency virus (HIV)-infected adolescent with hemophilia A who was receiving amprenavir (APV).
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Scalp video-EEG monitoring was obtained using the standard 10/20 system of electrode placement.
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The anticonvulsant drug lacosamide selectively enhances slow inactivation of voltage-gated sodium channels and has been shown to be an effective add-on treatment for partial-onset seizures.
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