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His medical history was significant for 5-FU bolus injections for intestinal cancer since May 1998.
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These skin lesions may be induced or worsened during antiviral therapy with interferon-alpha (IFN).
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Although retinoic acid is well tolerated by the majority of patients with this disease, a potentially fatal complication of this kind of treatment has been reported: "the retinoic acid syndrome".
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A 36-year-old man being treated with cisplatinum, vinblastine, and bleomycin for testicular carcinoma developed a dense left homonymous hemianopsia, encephalopathy, and a partial nondominant parietal lobe syndrome.
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Protease inhibitor-associated angiolipomatosis.
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Our case report suggests that posaconazole is an attractive treatment option in patients with peritoneal dialysis-related Mucor peritonitis.
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During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.
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The two previously unreported adverse effects are a diffuse loss of color discrimination and an increased time course to complete dark adaptation.
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Presented is a case story of a woman with classical rheumatoid arthritis, who during introduction of sulphasalazine (SASP) therapy developed a severe and lasting psoriasis-like skin reaction.
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CONCLUSIONS: Anastrozole may be the causative factor in patients with sclerosing glomerulonephritis.
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The concentration of pseudoephedrine in blood and liver specimens was measured using gas chromatography-mass spectrometry and was determined to be 14.4 mg/L in the blood and 16 mg/kg in the liver.
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Although current recommendations state that TZDs should not be administered to patients with New York Heart Association class III or IV disease, practitioners should be aware that these adverse effects also may occur in patients with milder forms heart failure as well as those without heart failure.
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Ramipril was stopped and he required a course of steroids after which the rash improved slowly.
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Obsessive-compulsive symptoms suddenly emerged 10 days after starting risperidone and resolved within 3 days of discontinuation.
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Subfulminant hepatitis B after infliximab in Crohn's disease: need for HBV-screening?
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PARTICIPANTS: Seven patients (eight patient visits) with an age range of 5 days to 14.9 years.
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We report a case of hyperpigmentation due to bleomycin treatment in a patient with acquired immune deficiency syndrome (AIDS).
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We also describe a new, noninvasive method to assess magnesium-induced neuromuscular block when curariform muscle relaxant was given simultaneously.
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Resolution of the interface inflammation did not occur until intraocular pressure was controlled.
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The discontinuation of heavy caffeine intake appears to have contributed to the outcome.
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DISCUSSION: Olanzapine, like other atypical antipsychotic drugs, may cause muscle injury with concomitant elevations of serum CK of muscle origin.
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A postmortem toxicology analysis reported a fluoxetine concentration of 4500 mcg/L and diazepam of 500 mcg/L.
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A correlation between dose and manifestation was investigated but none was found.
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The overall response rate was 20%, and a further 40% achieved stable disease.
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The two patients underwent several courses of pulse corticosteroid therapy, each course consisting of three days of methylprednisolone 1000 mg daily, resulting in visual recovery to some extent.
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Neutropenia and agranulocytosis are risks known to occur with phenothiazines and clozapine.
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Clinical examination revealed 2 distinct corneal infiltrates beneath the LASIK flap.
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However, electron microscopy disclosed focal mesangial interposition, irregular thickening of the glomerular basement membrane and subendothelial loosening.
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This severe illness was likely caused by minocycline, and we speculate that minocycline may have acted as a superantigen, causing lymphocyte over-activation and massive cytokine release.
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These findings support previous studies that showed that the use of aspirin during the antecedent illness may be a risk factor for the development of RS.
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Although it is difficult to solely attribute intratumoral hemorrhage to aspirin, we have to be careful when prescribing aspirin for patients who have asymptomatic meningioma.
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Pulmonary hemorrhage as a clinical manifestation of hemolytic-uremic syndrome associated with mitomycin C therapy.
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Perforated appendicitis and ectopic pregnancy following in-vitro fertilization.
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To our knowledge, this is the first such reported thrombotic event.
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Fenofibrate administration is associated with a uric acid lowering effect.
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The authors describe a case of combined lithium and haloperidol toxicity characterized by hyperpyrexia, severe rigidity, mutism, and development of irreversible tardive dyskinesia.
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Multiple pulmonary nodules: an unusual presentation of fludarabine pulmonary toxicity: case report and review of literature.
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METHODS: Skin prick test (SPT), nasal and intramuscular challenge test with commercial salmon calcitonin (Miacalcic) were performed.
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Our case points to the need for increased awareness by the general pediatricians of the potential hazards of mineral oil use for chronic constipation.
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We report a case of Zidovudine induced anaemia and bone marrow aplasia in a patient infected with HIV.
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Bronchial anthracostenosis with mediastinal fibrosis associated with long-term wood-smoke exposure.
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Further investigation is needed to determine the scope of this troubling side effect.
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Chest computed tomography showed the characteristic findings of septic pulmonary emboli (SPE).
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Clonazepam for the treatment of lancinating phantom limb pain.
| 0 |
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We report a patient who developed CD7+ therapy-related acute myeloid leukemia (t-AML) with trisomy 8 after chemotherapy for AML.
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Both patients completed the planned course of radiotherapy without interruption, after administration of G-CSF.
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Pemphigus foliaceus induced by rifampicin.
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She developed pruritus, edema, and urticaria over both hands.
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CONCLUSION: The increasing role of radiotherapy in nasopharyngeal carcinoma treatment, together with improved patient survival, is likely to lead to radiation-induced, secondary, space-occupying lesions being encountered more frequently.
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Neurological side effects in two patients receiving gold injections for rheumatoid arthritis.
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Estimation of maternal PIVKA levels may be of value for predicting risk of hemorrhage in the neonate.
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Pulmonary oedema after hexoprenaline administration in preterm labour.
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Three months after hospital discharge, the abdominal pain did not recur.
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The focus of this case report is to create awareness within the clinician that, in addition to evaluating the patient for the disease related issues that may affect the oral cavity and dentition, a total management plan should include factors beyond the structural oral problems related to the cancer.
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After therapy for diabetic coma with insulin (containing the preservative cresol) and electrolyte solutions was started, the patient complained of increasing myalgia, developed a high fever and respiratory and metabolic acidosis and lost consciousness.
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A regimen of topical INF alpha 2-beta 4 times daily was administered.
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On admission, high levels of arterial hypertension were found.
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We report a case of radiotherapy-enhanced aminoglutethimide skin toxicity in a patient with metastatic breast cancer.
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This regimen is administered in cycles of approximately 3 weeks; a total course of treatment consists of six cycles.
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METHODS: Thirteen consecutive patients with unresectable multifocal HCC and resistance to TAE were treated with combination chemotherapy consisting of arterial chemoembolization with degradable starch microspheres (DSM) (150-4500 mg on Day 1), mitomycin-C (4-8 mg on Day 1), continuous arterial infusion of 5-fluorouracil (1250 mg/120 h), cisplatin (25-50 mg/120 h) and l-leucovorin (125 mg/120 h) for 10-19 weeks.
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After 5 weeks of therapy, she stopped taking pantoprazole due to general malaise.
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Severe acidosis in patients taking metformin--rapid reversal and survival despite high APACHE score.
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JHR is a self-limiting condition that warrants the continuation of antibiotic treatment in syphilis patients.
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To develop information on the relative rarity or frequency of neurologic worsening with the initiation of penicillamine therapy, we conducted a retrospective survey of 25 additional patients with Wilson's disease who met the criteria of presenting with neurologic disease and having been treated with penicillamine.
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The current report describes a man who was prescribed zonisamide for epilepsy and subsequently developed widespread skin rash, acute kidney injury, high-grade fever, eosinophilia, liver dysfunction, lymphadenopathy and an increase in antihuman herpesvirus-6 immunoglobulin G titer.
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Oxime therapy should be considered even late in the course of untreated or partially treated OP intoxications, especially when the etiologic agent is a lipid-soluble compound (ie malathion) that can cause a protracted course of poisoning.
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It can progress rapidly to high fever, altered mental status, seizures, profound muscle rigidity, rhabdomyolysis, brain injury, and death.
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The patient developed Leuconostoc bacteremia secondary to peritonitis, 60 d after undergoing liver transplantation.
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There was no indication that the increase in anaphylactoid reactions was associated with the use of hyperthermia.
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a 67-year-old man with bipolar disorder developed a Creutzfeldt-Jakob like syndrome during lithium carbonate treatment.
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Although asymptomatic, the biochemical abnormality improved after discontinuation of carbamazepine.
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Except for generalized cerebral gliosis, the abnormalities in the brain were confined to the cerebellum, where malformation of the dentate nuclei, neuronal heterotopias, and abnormalities of Purkinje's cell dendrites were found.
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He gradually improved and his biochemical markers returned to normal.
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These in vitro findings and clinical course suggest that TRAb/TBII without thyroid-stimulating activity may develop in patients with amiodarone-induced destructive thyroiditis, as reported in patients with destructive thyroiditis, such as subacute and silent thyroiditis.
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The quality of life was assessed in 37 maintenance hemodialysis patients during treatment with recombinant human erythropoietin (r-HuEPO; EPOGEN [epoetin alfa], AMGEN Inc, Thousand Oaks, CA) for correction of anemia.
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We conclude that intoxication with lacosamide, in combination with overdoses of multiple AEDs, can be survived without sequelae, even after ingestion of 12 g lacosamide.
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Until additional data are available, if intravenous acyclovir is administered concurrently with lithium, we recommend closely monitoring patients for signs of lithium toxicity and measuring serum lithium levels every second or third day.
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Although adverse effects are usually mild, the author reports here a case of leucocytopenia and thrombocytopenia with quetiapine treatment that required its discontinuation.
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It is particularly important in the treatment of systemic lupus erythematosus (SLE) since it reduces new organ involvement and disease flares, and relieves skin and joint symptoms.
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After unsuccessful therapy with ganciclovir and foscarnet, combined antiviral and anti-inflammatory treatment with cidofovir and prednisolone controlled the HHV-6 infection and enabled resolution of clinical symptoms.
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A review of the literature, which yielded 23 other reports of endocarditis due to this organism, suggests that Lactobacillus is a rare cause of endocarditis.
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Stupor and fast activity on electroencephalography in a child treated with valproate.
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The patient was successfully treated with heparin and subsequently with warfarin and dipyridamole.
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We conclude that while thrombocytopenia and schistocytosis can be seen in quinine-associated TTP/HUS, the pathophysiology seems to be distinct from that seen in most cases of idiopathic TTP (i.e., severely decreased ADAMTS13 with an inhibitor).
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We report a patient with inoperable pancreatic cancer who developed gastrointestinal bleeding secondary to radiation-recall related to gemcitabine and review literature.
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DESIGN: Case report.
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Before onset of treatment, level of GABA in CSF was highly lowered (16 pmol/ml), pyridoxine level in serum was within normal range.
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CASE REPORT: We present cases of 10 patients with Type 2 diabetes mellitus who developed acute renal failure and severe lactic acidosis.
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We note that ITB withdrawal is similar to serotonergic syndromes, such as in overdoses of selective serotonin reuptake inhibitors or the popular drug of abuse 3,4-methylenedioxymethamphetamine (Ecstasy).
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An immediate cholestatic liver reaction was also provoked by drug rechallenge, with spontaneous amelioration of signs and symptoms after drug discontinuation.
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Her postoperative course was further complicated by a fungal infection.
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Although the literature on the use of risperidone in elderly patients with dementia consists largely of uncontrolled trials, case reports, and chart reviews, it appears that this agent is effective for managing agitation in this population and does so with a low frequency of extrapyramidal symptoms (EPS).
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Subsequently, the pedicle screws were removed.
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Other organisms, including unusual bacteria, fungi, and mycobacteria, comprise 5% or less of cases.
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Inadvertent injection of corticosteroid into the choroidal vasculature.
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Further study of this potential health risk in needed.
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Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.
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No other identifiable factor contributed to the unresponsiveness.
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LTG toxicity should be considered in patients taking this drug who have depressed mental status.
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DESIGN: Noncomparative, interventional case series.
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