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Gabapentin toxicity in renal failure: the importance of dose adjustment.
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The morbidity and lethality of AL amyloidosis is caused by the deposition of lg light chains as fibrillar amyloid protein in vital organs, disrupting their function, and not by the generally low burden of clonal plasma cells that produce the paraproteins.
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An outbreak of multiple-drug-resistant Salmonella enteritis from raw milk.
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Similar material was located in the major choroidal vessels.
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It was confirmed that these dermatitis reactions were due to contact and/or photocontact allergy to psoralens by several methods that include patch and photopatch tests, photopatch test mapping, determination of the minimal erythema dose (MED) and immunohistochemistry.
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The patient had been treated with four kinds of antihistamines and antiallergenic drugs.
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On further questioning, the patient admitted to the daily use of mineral oil for constipation.
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STUDY DESIGN: A case report is presented.
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Systemic corticosteroids in the phenytoin hypersensitivity syndrome.
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The dose was subsequently increased to 200 and 400 mg/day on alternate days, six days per week, and two months later AVT occurred.
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Central nervous system (CNS) disturbances, reported in 12 patients, were the most common unwanted effects.
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Several biopsies yielded a mold initially phenotypically identified as a Penicillium species, but molecular sequence analysis ultimately determined the identity as Paecilomyces lilacinus.
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Microdeletions of 22q11.2 are the main etiology for DiGeorge syndrome, a disorder characterized by heart defects, immune deficiencies due to aplasia or hypoplasia of the thymus, and hypocalcemia.
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However our case report demonstrates that early and aggressive treatment with haemofiltration can improve outcomes even in the presence of severe acidosis.
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A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.
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A 63-year-old man with hypothyroidism is described.
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Subfulminant syncytial giant cell hepatitis: recurrence after liver transplantation treated with ribavirin.
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The use of bivalirudin alone is as effective and has been associated with less bleeding than the use of UFH or enoxaparin plus a glycoprotein (GP) IIb/ IIIa inhibitor in patients with NSTE ACS who undergo PCI.
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The cat was admitted with acute respiratory distress, vomiting, and collapse, which began 15 to 20 minutes after topical application of the drug.
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RESULTS: After 4- to 14-month period of therapy with the combination of indapamide (2.5 mg/day) and fosinopril (10 mg/day) in three patients and 6-month period of monotherapy with indapamide (2.5 mg/day) in one patient, glucose levels of all patients increased and achieve criteria of diabetes diagnoses.
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In 1992, some 90 countries or territories where 42% of the world's population resided were considered malarious and estimation of deaths from malaria worldwide per year were in the order of 1.4 of 2.8 million.
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Morphine, an opium alkaloid, frequently causes side effects such as hyperhidrosis and facial flushing, but serious cutaneous adverse drug reactions are seldom observed.
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Survivors of childhood solid tumors including Ewing sarcoma (ES) have an increased risk of secondary malignant neoplasms (SMNs) as a consequence of exposure to chemotherapy and/or radiation (see: Bhatia S, Sklar C.
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The authors report two cases of delayed elimination of methotrexate in patients receiving ciprofloxacin, with severe toxicity.
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Six isolated reports of prenatally exposed infants with various congenital anomalies exist, but to date no specific phenotype has been delineated.
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At hospital discharge, platelet testing showed hyper response to antiplatelet therapy with very low post treatment platelet reactivity.
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In four patients the maximum ST elevation was greater than or equal to 5 mm.
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The cause of these previously unreported side effects of niacin therapy is uncertain but may be related to prostaglandin-mediated vasodilatation, hyperalgesia of sensory nerve receptors, and potentiation of inflammation in the gingiva with referral of pain to the teeth.
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The patients treated with bromocriptine at 7.5-15 mg/day adjunctive to l-dopa were selected to replace bromocriptine with pergolide of the equivalent dosage approved in Japan.
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CONCLUSIONS: Spontaneous hemothorax is a rare phenomenon in conjunction with LMWH but should be considered in cases of acute respiratory distress following commencement of LMWH.
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Successful treatment with arsenic trioxide of a patient with ATRA-resistant relapse of acute promyelocytic leukemia.
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After diagnosis of epidural lipomatosis on magnetic resonance imaging, the patient underwent decompressive thoraco-laminectomy.
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Uveitis during treatment of disseminated Mycobacterium avium-intracellulare complex infection with the combination of rifabutin, clarithromycin and ethambutol.
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Stroke-like syndrome after gold sodium thiomalate induced vasomotor reaction.
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A broad-spectrum antibiotic regimen included a penicillinase-resistant preparation because of the frequent involvement of Staphylococcus aureus.
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Patients with cell-mediated immune defects are at higher risk for acquiring infections with Salmonella species.
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An 11-year-old boy developed a severe enteropathy 2 years after initiation of clofazimine treatment for graft-versus-host disease.
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The incidence of RS among children with juvenile rheumatoid arthritis is significantly greater than the incidence of RS among children who do not have juvenile rheumatoid arthritis.
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A 55-year-old man developed acute myocardial infarction (AMI) related to a large coronary artery aneurysm and a distal coronary stenotic lesion after steroid therapy for systemic lupus erythematosus (SLE).
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Reversible sclerotic changes of lumbar spine and femur due to long-term oral isotretinoin therapy.
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Based upon the observed fall of the filtration fraction, the rise in the relative clearance of 99Tc-dimercaptosuccinic acid and the increase in proteinuria, we suggest that in this case the tubules and/or interstitium are the main targets for cyclosporine A nephrotoxicity.
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The skin was hard, shiny and hairless.
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Corynebacterium striatum: a diphtheroid with pathogenic potential.
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We report a case of a woman with ectopic pregnancy with fetal cardiac activity after ovulation induction and transvaginal intratubal insemination by tactile sensation.
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Rapid improvement in muscle strength accompanied by prompt resolution of abnormal elevation of muscle enzymes followed cessation of both medications.
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This case illustrates that PCR is a rapid technique for the early diagnosis of TA-GVHD.
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Amikacin-induced type 5 Bartter-like syndrome with severe hypocalcemia.
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As nephrotic-range proteinuria, hypoalbuminemia, and general edema were worsening even 2 weeks after cessation of the drug, oral corticosteroid therapy (prednisolone 40 mg/day) was started.
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A 53-year-old woman presented with an extensively metastatic and rapidly growing breast adenocarcinoma, markedly elevated lactate dehydrogenase, and mildly elevated blood urea nitrogen.
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The potential anticonvulsant effect of these drugs was successfully reversed by the administration of intravenous flumazenil just prior to the treatments.
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The events of non-convulsive status epilepticus subsided following reduction in tiagabine dosages.
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Postrenal failure was excluded by echography.
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Gynaecomastia due to anti-tubercular chemotherapy is a rare side effect.
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Differential diagnoses included ocular rosacea with cicatrizing conjunctivitis and 5-FU-induced ectropion.
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The patient developed severe ovarian hyperstimulation and became pregnant with an ectopic gestation after ovulation induction.
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The use of plasma exchange in quinine-TMA is called into question.
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Here, we will describe three episodes of NMS that fulfilled the DSM-IV criteria for NMS (APA, 1994).
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Theophylline intoxication following viloxazine induced decrease in clearance.
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Ocular motor and imaging abnormalities of midbrain dysfunction in osmotic demyelination syndrome.
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CONCLUSION: Risperidone was an effective and safe treatment in three cases of delusions of infestation.
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The standard treatment for late infections of knee prostheses is a two-stage reimplantation with a temporary articulating spacer between operations, but there is no universal agreement as to the best type of spacer to be used and surgeons have created modifications according to their technical and economic resources.
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Upon analysis of plasma VWF multimers (VWFMs) in this patient, those with large to medium molecular masses more selectively disappeared before the IV-Ig infusion than did those with small molecular masses.
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PURPOSE: The case of a patient who developed aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension simultaneously during treatment with trimethoprim-sulfamethoxazole is described.
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A fibrinolytic therapy with recombinant tissue-type plasminogen activator according to the Neuhaus scheme was attempted.
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The results of laboratory tests revealed elevated levels of hepatic enzymes, including alanine transaminase (ALT) and aspartate transaminase (AST).
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The patient's medications had been stable for at least six months except for the addition of carbamazepine one month before his arrival at the ED.
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We discuss other similar cases so physicians continue to be aware of this rare yet potentially life-threatening reaction to a commonly used medication.
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DISCUSSION: Neonates may be at particular risk for TLS given their immature renal function and its predisposition toward metabolic derangements.
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Moreover, she had changed her antiperspirant 1 week before the onset of the lesions.
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Here we report on a patient with schizophrenia who suffered from medication-refractory coprophagia.
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Otolaryngologists should be made aware of a newer cause of nasal septal perforations resulting from the more recent antiangiogenic therapy used to treat malignancies.
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CASE SUMMARY: A 59-year-old man was diagnosed with squamous-cell carcinoma of the lung in T4N2M0 stage and treated with cisplatin, vinorelbine, and gemcitabine.
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Carbamazepine induced right bundle branch block in a Greenlandic patient.
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A 47-y-old female underwent revision of a left total hip replacement because of loose prosthesis.
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Clozapine-induced akathisia in children with schizophrenia.
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From this study and the previously available data, we conclude that this drug is too toxic for human trials at the currently recommended doses.
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We also review evidence that the risk of this complication is substantially lower with the newer nonergot dopamine agonists.
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Brugada type electrocardiographic changes induced by concomitant use of lithium and propafenone in patient with Wolff-Parkinson-White syndrome.
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That the drug was directly responsible for the observed complications is suggested by the clinical course and by in vitro lymphocyte transformation studies.
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A renal tubular abnormality may have allowed the usually self-limiting acidosis of acetazolamide to progress.
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A case is presented of a patient who experienced benzodiazepine withdrawal symptoms on discontinuation of nefazodone, an antidepressant that inhibits the cytochrome P450 3A4 isoenzyme.
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A 28-y-old male with end stage renal failure (ESRF) received an overdose of atenolol.
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CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.
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Mycophenolate mofetil in a dose of 1.0-2.0 g/day was given in 2 patients with severe refractory myasthenia gravis and in 1 patient with myasthenia gravis-polymyositis syndrome.
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He was started on digoxin, 0.25 mg daily, because of echocardiographically demonstrated left ventricular dilatation and functional impairment; he died of ventricular fibrillation 15 days later.
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Fourteen days of treatment with ganciclovir led to a prompt improvement in the symptoms of colitis, resolution of the pyrexia, normalisation of the liver function tests, and clearance of the virus, as measured by a negative cytomegalovirus DNA PCR.
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Most asthma drugs are inhaled using various forms of inhalers or nebulizers.
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A retrospective review of TTP patients with quinine-associated thrombotic microangiopathy (TMA) for whom ADAMTS13 was measured before plasma exchange was performed.
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Mitomycin C (MMC) is an alkylating agent that has been recently associated with the hemolytic-uremic syndrome (HUS).
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RESULTS: The injection demonstrated the block in the catheter.
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Infants are particularly susceptible to chronic nitrate-induced methemoglobinemia because of their low stomach acid production, large numbers of nitrite-reducing bacteria, and the relatively easy oxidation of fetal hemoglobin.
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Tacrolimus was substituted for cyclosporine on day 20; on day 21 amlodipine was initiated to manage hypertension.
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Ceftriaxone was approved in 1997 for the treatment of otitis media despite previous studies that documented an association of ceftriaxone with elevated hepato-biliary enzymes and transient biliary stasis.
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A 66-year-old pseudophakic man with primary open-angle glaucoma and ocular cicatricial pemphigoid underwent trabeculectomy and was given postoperative subconjunctival 5-fluorouracil.
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Renal function gradually improved but nephrotic state was persistent.
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The toxic effects of methotrexate included elevated liver transaminases (3/4), nausea (2/4), abdominal pain (2/4), bone pain (2/4), mild neutropenia (1/4), and mild pruritus (1/4).
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Inhaled tobramycin solution-associated recurrent eosinophilia and severe persistent bronchospasm in a patient with cystic fibrosis: a case report.
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Because the efficacy of the prophylactic use of lamivudine has been reported and the steroid enhances curability of malignant lymphoma, the steroid containing regimen with prophylaxis of lamivudine should be evaluated further.
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OBJECTIVE: To investigate the mechanisms involved in hypersensitivity reactions to cyclosporine and determine the feasibility of future cyclosporine use.
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Thus, perospirone is an agent with possible efficacy for medication-refractory schizophrenia.
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