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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Patients currently receiving diltiazem therapy should be carefully monitored for a change in pharmacological effect when initiating and discontinuing therapy with cimetidine.
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<diltiazem, advise, cimetidine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Administration of diltiazem hydrochloride with digoxin in 24 healthy male subjects increased plasma digoxin concentrations approximately 20%.
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<diltiazem hydrochloride, mechanism, digoxin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Since there have been conflicting results regarding the effect of digoxin levels, it is recommended that digoxin levels be monitored when initiating, adjusting, and discontinuing diltiazem hydrochloride therapy to avoid possible over- or under-digitalization.
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<digoxin, advise, diltiazem hydrochloride>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
The depression of cardiac contractility, conductivity, and automaticity as well as the vascular dilation associated with anesthetics may be potentiated by calcium channel blockers.
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<anesthetics, effect, calcium channel blockers>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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When used concomitantly, anesthetics and calcium channel blockers should be titrated carefully.
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<anesthetics, advise, calcium channel blockers>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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A pharmacokinetic interaction between diltiazem and cyclosporine has been observed during studies involving renal and cardiac transplant patients.
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<diltiazem, int, cyclosporine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
In renal and cardiac transplant recipients, a reduction of cyclosporine dose ranging from 15% to 48% was necessary to maintain cyclosporine trough concentrations similar to those seen prior to the addition of diltiazem.
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<cyclosporine, mechanism, diltiazem>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
If these agents are to be administered concurrently, cyclosporine concentrations should be monitored, especially when diltiazem therapy is initiated, adjusted, or discontinued.
|
<cyclosporine, advise, diltiazem>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Concomitant administration of diltiazem with carbamazepine has been reported to result in elevated serum levels of carbamazepine (40% to 72% increase), resulting in toxicity in some cases.
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<diltiazem, mechanism, carbamazepine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Studies showed that diltiazem increased the AUC of midazolam and triazolam by 3-4 fold and the Cmax by 2-fold, compared to placebo.
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<diltiazem, mechanism, midazolam>, <diltiazem, mechanism, triazolam>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
The elimination half life of midazolam and triazolam also increased (1.5-2.5 fold) during coadministration with diltiazem.
|
<midazolam, mechanism, diltiazem>, <triazolam, mechanism, diltiazem>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
These pharmacokinetic effects seen during diltiazem coadministration can result in increased clinical effects (e.g., prolonged sodation)of both midazolam and triazolam.
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<diltiazem, effect, midazolam>, <diltiazem, effect, triazolam>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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In a ten-subject study, coadministration of diltiazem (120 mg bid) with lovastatin resulted in a 3-4 times increase in mean lovastatin AUC and Cmax vs. lovastatin alone;
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<diltiazem, mechanism, lovastatin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Coadministration of rifampin with diltiazem lowered the diltiazem plasma concentrations to undetectable levels.
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<rifampin, mechanism, diltiazem>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Coadministration of diltiazem with rifampin or any known CYP3A4 inducer should be avoided when possible, and alternative therapy considered.
|
<diltiazem, advise, rifampin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Combinations of these drugs have not been studied and coadministration of CRIXIVAN and atazanavir is not recommended.
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<CRIXIVAN, advise, atazanavir>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Dose reduction of CRIXIVAN to 600 mg every 8 hours should be considered when taking delavirdine 400 mg three times a day.
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<CRIXIVAN, advise, delavirdine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Indinavir and didanosine formulations containing buffer should be administered at least one hour apart on an empty stomach.
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<Indinavir, advise, didanosine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Increasing the indinavir dose to 1000 mg every 8 hours does not compensate for the increased indinavir metabolism due to efavirenz.
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<indinavir, mechanism, efavirenz>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Indinavir concentrations may be decreased in the presence of nevirapine.
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<Indinavir, mechanism, nevirapine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Preliminary clinical data suggest that the incidence of nephrolithiasis is higher in patients receiving indinavir in combination with ritonavir than those receiving CRIXIVAN 800 mg q8h.
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<indinavir, effect, ritonavir>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Caution is warranted and therapeutic concentration monitoring is recommended for antiarrhythmics when coadministered with CRIXIVAN.
|
<antiarrhythmics, advise, CRIXIVAN>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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CRIXIVAN may not be effective due to decreased indinavir concentrations in patients taking these agents concomitantly.
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<CRIXIVAN, effect, indinavir>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Use lowest possible dose of atorvastatin with careful monitoring, or consider HMG-CoA reductase inhibitors that are not primarily metabolized by CYP3A4, such as pravastatin, fluvastatin, or rosuvastatin in combination with CRIXIVAN.
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<atorvastatin, advise, CRIXIVAN>, <HMG-CoA reductase inhibitors, advise, CRIXIVAN>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Dose reduction of CRIXIVAN to 600 mg every 8 hours is recommended when administering itraconazole concurrently.
|
<CRIXIVAN, advise, itraconazole>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Dose reduction of rifabutin to half the standard dose and a dose increase of CRIXIVAN to 1000 mg (three 333-mg capsules) every 8 hours are recommended when rifabutin and CRIXIVAN are coadministered.
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<rifabutin, advise, CRIXIVAN>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Sildenafil dose should not exceed a maximum of 25 mg in a 48- hour period in patients receiving concomitant indinavir therapy.
|
<Sildenafil, advise, indinavir>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Tadalafil dose should not exceed a maximum of 10 mg in a 72- hour period in patients receiving concomitant indinavir therapy.
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<Tadalafil, advise, indinavir>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Vardenafil dose should not exceed a maximum of 2.5 mg in a 24-hour period in patients receiving concomitant indinavir therapy.
|
<Vardenafil, advise, indinavir>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Digoxin: Coadministration of digoxin, a P-glycoprotein substrate, with oral conivaptan resulted in a reduction in clearance and an increase in digoxin Cmax and AUC values.
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<digoxin, mechanism, conivaptan>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Therefore, if digoxin is administered with VAPRISOL, the clinician should be alert to the possibility of increases in digoxin levels.
|
<digoxin, mechanism, VAPRISOL>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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There have been isolated reports of patients experiencing increases in their prothrombin times when etidronate was added to warfarin therapy.
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<etidronate, effect, warfarin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Wait 5 weeks after stopping escitalopram before starting a non-selective MAO inhibitor.
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<escitalopram, advise, non-selective MAO inhibitor>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Wait 2 weeks after stopping an MAO inhibitor before starting escitalopram.
|
<MAO inhibitor, advise, escitalopram>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Erythromycin use in patients who are receiving high doses of theophylline may be associated with an increase in serum theophylline levels and potential theophylline toxicity.
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<Erythromycin, effect, theophylline>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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In case of theophylline toxicity and/or elevated serum theophylline levels, the dose of theophylline should be reduced while the patient is receiving concomitant erythromycin therapy.
|
<theophylline, advise, erythromycin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Concomitant administration of erythromycin and digoxin has been reported to result in elevated digoxin serum levels.
|
<erythromycin, mechanism, digoxin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
There have been reports of increased anticoagulant effects when erythromycin and oral anticoagulants were used concomitantly.
|
<erythromycin, effect, anticoagulants>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Concurrent use of erythromycin and ergotamine or dihydroergotamine has been associated in some patients with acute ergot toxicity characterized by severe peripheral vasospasm and dysesthesia.
|
<erythromycin, effect, ergotamine>, <erythromycin, effect, dihydroergotamine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Erythromycin has been reported to decrease the clearance of triazolam and midazolam and thus may increase the pharmacologic effect of these benzodiazepines.
|
<Erythromycin, mechanism, triazolam>, <Erythromycin, mechanism, midazolam>, <Erythromycin, effect, benzodiazepines>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
There have been reports of interactions of erythromycin with carbamazepine, cyclosporine, tacrolimus, hexobarbital, phenytoin, alfentanil, cisapride, disopyramide, lovastatin, bromocriptine, valproate, terfenadine, and astemizole.
|
<erythromycin, int, carbamazepine>, <erythromycin, int, cyclosporine>, <erythromycin, int, tacrolimus>, <erythromycin, int, hexobarbital>, <erythromycin, int, phenytoin>, <erythromycin, int, alfentanil>, <erythromycin, int, cisapride>, <erythromycin, int, disopyramide>, <erythromycin, int, lovastatin>, <erythromycin, int, bromocriptine>, <erythromycin, int, valproate>, <erythromycin, int, terfenadine>, <erythromycin, int, astemizole>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Erythromycin has been reported to significantly alter the metabolism of nonsedating antihistamines terfenadine and astemizole when taken concomitantly.
|
<Erythromycin, mechanism, terfenadine>, <Erythromycin, mechanism, astemizole>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
In addition, deaths have been reported rarely with concomitant administration of terfenadine and erythromycin.
|
<terfenadine, effect, erythromycin>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
There have been postmarketing reports of drug interactions when erythromycin is coadministered with cisapride, resulting in QT prolongation, cardiac arrythmias, ventricular tachycardia, ventricular fibrulation, and torsades de pointes, most like due to inhibition of hepatic metabolism of cisapride by erythromycin.
|
<erythromycin, effect, cisapride>, <cisapride, mechanism, erythromycin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Patients receiving concomitant lovastatin and erythromycin should be carefully monitored;
|
<lovastatin, advise, erythromycin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Because the tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.
|
<tetracyclines, advise, anticoagulant>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Since bacteriostatic drugs, such as the tetracycline class of antibiotics, may interfere with the bactericidal action of penicillins, it is not advisable to administer these drugs concomitantly.
|
<tetracycline class, effect, penicillins>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective.
|
<tetracyclines, effect, contraceptives>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Increases in prothrombin time have been noted in patients receiving long- term warfarin therapy after flutamide was initiated.
|
<warfarin, effect, flutamide>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Therefore, close monitoring of prothrombin time is recommended and adjustment of the anticoagulant dose may be necessary when EULEXIN Capsules are administered concomitantly with warfarin.
|
<EULEXIN, advise, warfarin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
in one man, the C max of terfenadine was 8.1 ng/mL with terfenadine alone and 7.2 ng/mL with terfenadine plus dirithromycin.
|
<terfenadine, mechanism, dirithromycin>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
The mean QT c interval (msec) was 369 with terfenadine alone and 367 with terfenadine plus dirithromycin.
|
<terfenadine, effect, dirithromycin>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Thus, the interaction observed between erythromycin and terfenadine is not expected for dirithromycin.
|
<erythromycin, int, terfenadine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Serious cardiac dysrhythmias, some resulting in death, have occurred in patients receiving terfenadine concomitantly with other macrolide antibiotics.
|
<terfenadine, effect, macrolide antibiotics>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
In addition, most macrolides are contraindicated in patients receiving terfenadine therapy who have pre-existing cardiac abnormalities (arrhythmia, bradycardia, QT c interval prolongation, ischemic heart disease, congestive heart failure, etc.) or electrolyte disturbances.
|
<macrolides, advise, terfenadine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Antacids or H 2 receptor antagonists: When dirithromycin is administered immediately following antacids or H 2 -receptor antagonists, the absorption of dirithromycin is slightly enhanced.
|
<dirithromycin, mechanism, antacids>, <dirithromycin, mechanism, H 2 -receptor antagonists>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Triazolam: Erythromycin has been reported to decrease the clearance of triazolam and, thus, may increase the pharmacologic effect of triazolam.
|
<Erythromycin, mechanism, triazolam>, <Erythromycin, effect, triazolam>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Digoxin: Concomitant administration of erythromycin and digoxin has been reported to result in elevated digoxin serum levels.
|
<erythromycin, mechanism, digoxin>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Anticoagulants: There have been reports of increased anticoagulant effects when erythromycin and oral anticoagulants were used concomitantly.
|
<erythromycin, effect, anticoagulants>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Ergotamine: Concurrent use of erythromycin and ergotamine or dihydroergotamine has been associated in some patients with acute ergot toxicity characterized by severe peripheral vasospasm and dysesthesia.
|
<erythromycin, effect, ergotamine>, <erythromycin, effect, dihydroergotamine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Other drugs Drug interactions have been reported with concomitant administration of erythromycin and other medications, including cyclosporine, hexobarbital, carbamazepine, alfentanil, disopyramide, phenytoin, bromocriptine, valproate, astemizole, and lovastatin.
|
<erythromycin, int, cyclosporine>, <erythromycin, int, hexobarbital>, <erythromycin, int, carbamazepine>, <erythromycin, int, alfentanil>, <erythromycin, int, disopyramide>, <erythromycin, int, phenytoin>, <erythromycin, int, bromocriptine>, <erythromycin, int, valproate>, <erythromycin, int, astemizole>, <erythromycin, int, lovastatin>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
The safety and efficacy of concomitant use of REVIA and disulfiram is unknown, and the concomitant use of two potentially hepatotoxic medications is not ordinarily recommended unless the probable benefits outweigh the known risks.
|
<REVIA, effect, disulfiram>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Lethargy and somnolence have been reported following doses of REVIA and thioridazine.
|
<REVIA, effect, thioridazine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Patients taking REVIA may not benefit from opioid containing medicines, such as cough and cold preparations, antidiarrheal preparations, and opioid analgesics.
|
<REVIA, effect, opioid>, <REVIA, effect, opioid analgesics>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
In an emergency situation when opioid analgesia must be administered to a patient receiving REVIA, the amount of opioid required may be greater than usual, and the resulting respiratory depression may be deeper and more prolonged.
|
<REVIA, effect, opioid>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Cholestyramine and colestipol resins: Absorption of hydrochlorothiazide is impaired in the presence of anionic exchange resins.
|
<hydrochlorothiazide, mechanism, anionic exchange resins>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Single doses of either cholestyramine or colestipol resins bind the hydrochlorothiazide and reduce its absorption from the gastrointestinal tract by up to 85 and 43 percent, respectively.
|
<cholestyramine, mechanism, hydrochlorothiazide>, <colestipol, mechanism, hydrochlorothiazide>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Lithium: generally should not be given with diuretics.
|
<Lithium, advise, diuretics>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity.
|
<Diuretic agents, mechanism, lithium>, <Diuretic agents, effect, lithium>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Refer to the package insert for lithium preparations before use of such preparations with Hydrochlorothiazide.
|
<lithium, advise, Hydrochlorothiazide>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Non-steroidal Anti-inflammatory Drugs: In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics.
|
<non-steroidal anti-inflammatory agent, effect, loop diuretics>, <non-steroidal anti-inflammatory agent, effect, potassium-sparing diuretics>, <non-steroidal anti-inflammatory agent, effect, thiazide diuretics>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Therefore, when Hydrochlorothiazide and non-steroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained.
|
<Hydrochlorothiazide, advise, non-steroidal anti-inflammatory agents>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Increased nephrotoxicity has been reported following concomitant administration of cephalosporins and aminoglycoside antibiotics.
|
<cephalosporins, effect, aminoglycoside antibiotics>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Patients who are applying Panretin gel should not concurrently use products that contain DEET (N, N-diethyl-m-toluamide), a common component of insect repellent products.
|
<Panretin, advise, DEET>, <Panretin, advise, N-diethyl-m-toluamide>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Sulfacetamide preparations are incompatible with silver preparations.
|
<Sulfacetamide, int, silver>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
However, iloprost has the potential to increase the hypotensive effect of vasodilators and antihypertensive agents.
|
<iloprost, effect, vasodilators>, <iloprost, effect, antihypertensive agents>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Since iloprost inhibits platelet function, there is a potential for increased risk of bleeding, particularly in patients maintained on anticoagulants.
|
<iloprost, effect, anticoagulants>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
RAPTIVA should not be used with other immunosuppressive drugs.
|
<RAPTIVA, advise, immunosuppressive drugs>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Acellular, live and live-attenuated vaccines should not be administered during RAPTIVA treatment.
|
<Acellular vaccines, advise, RAPTIVA>, <live vaccines, advise, RAPTIVA>, <live-attenuated vaccines, advise, RAPTIVA>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Mineral oil interferes with the absorption of fat-soluble vitamins, including vitamin D preparations.
|
<Mineral oil, mechanism, fat-soluble vitamins>, <Mineral oil, mechanism, vitamin D preparations>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Administration of thiazide diuretics to hypoparathyroid patients who are concurrently being treated with ergocalciferol may cause hypercalcemia.
|
<thiazide diuretics, effect, ergocalciferol>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Netilmicin should not be administered concomitantly with potent loop diuretics such as furosemide and ethacrynic acid as the potential for ototoxicity is enhanced by the combination.
|
<Netilmicin, advise, loop diuretics>, <Netilmicin, advise, furosemide>, <Netilmicin, advise, ethacrynic acid>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Bentiromide may interact with acetaminophen (e.g., Tylenol), chloramphenicol (e.g., Chloromycetin), local anesthetics (e.g., benzocaine and lidocaine), para-aminobenzoic acid (PABA)-containing preparations (e.g., sunscreens and some multivitamins), procainamide (e.g., Pronestyl), sulfonamides (sulfa medicines), thiazide diuretics (use of these medicines during the test period will affect the test results), and pancreatic supplements (use of pancreatic supplements may give false test results).
|
<Bentiromide, int, acetaminophen>, <Bentiromide, int, Tylenol>, <Bentiromide, int, chloramphenicol>, <Bentiromide, int, Chloromycetin>, <Bentiromide, int, anesthetics>, <Bentiromide, int, benzocaine>, <Bentiromide, int, lidocaine>, <Bentiromide, int, para-aminobenzoic acid>, <Bentiromide, int, PABA>, <Bentiromide, int, multivitamins>, <Bentiromide, int, procainamide>, <Bentiromide, int, Pronestyl>, <Bentiromide, int, sulfonamides>, <Bentiromide, int, thiazide diuretics>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
When amiloride HCl is administered concomitantly with an angiotensin-converting enzyme inhibitor, the risk of hyperkalemia may be increased.
|
<amiloride, effect, angiotensin-converting enzyme inhibitor>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Lithium generally should not be given with diuretics because they reduce its renal clearance and add a high risk of lithium toxicity.
|
<Lithium, advise, diuretics>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics.
|
<non-steroidal anti-inflammatory agent, effect, loop diuretics>, <non-steroidal anti-inflammatory agent, effect, potassium-sparing diuretics>, <non-steroidal anti-inflammatory agent, effect, thiazide diuretics>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Therefore, when MIDAMOR and non-steroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained.
|
<MIDAMOR, advise, non-steroidal anti-inflammatory agents>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Since indomethacin and potassium-sparing diuretics, including MIDAMOR, may each be associated with increased serum potassium levels, the potential effects on potassium kinetics and renal function should be considered when these agents are administered concurrently.
|
<indomethacin, effect, potassium-sparing diuretics>, <indomethacin, effect, MIDAMOR>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
- Drugs with ototoxic potential: Especially in the presence of impaired renal function, the use of parenterally administered bumetanide in patients to whom aminoglycoside antibiotics are also being given should be avoided, except in life-threatening conditions.
|
<bumetanide, advise, aminoglycoside antibiotics>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
- Lithium: Lithium should generally not be given with diuretics (such as bumetanide) because they reduce its renal clearance and add a high risk of lithium toxicity.
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<Lithium, advise, diuretics>, <Lithium, advise, bumetanide>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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- Probenecid: Pretreatment with probenecid reduces both the natriuresis and hyperreninemia produced by bumetanide.
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<probenecid, effect, bumetanide>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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This antagonistic effect of probenecid on bumetanide natriuresis is not due to a direct action on sodium excretion but is probably secondary to its inhibitory effect on renal tubular secretion of bumetanide.
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<probenecid, mechanism, bumetanide>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Thus, probenecid should not be administered concurrently with bumetanide.
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<probenecid, advise, bumetanide>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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- Indomethacin: Indomethacin blunts the increases in urine volume and sodium excretion seen during bumetanide treatment and inhibits the bumetanide-induced increase in plasma renin activity.
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<Indomethacin, mechanism, bumetanide>, <Indomethacin, effect, bumetanide>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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- Antihypertensives: Bumetanide may potentiate the effect of various antihypertensive drugs, necessitating a reduction in the dosage of these drugs.
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<Bumetanide, effect, antihypertensive drugs>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, and beta adrenergic blocking agents.
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<sulfonylureas, effect, nonsteroidal anti-inflammatory agents>, <sulfonylureas, effect, salicylates>, <sulfonylureas, effect, sulfonamides>, <sulfonylureas, effect, chloramphenicol>, <sulfonylureas, effect, probenecid>, <sulfonylureas, effect, coumarins>, <sulfonylureas, effect, monoamine oxidase inhibitors>, <sulfonylureas, effect, beta adrenergic blocking agents>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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A possible interaction between glyburide and ciprofloxacin, a fluoroquinolone antibiotic, has been reported, resulting in a potentiation of the hypoglycemic action of glyburide.
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<glyburide, int, ciprofloxacin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reported.
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<miconazole, effect, hypoglycemic agents>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Although clinical studies have not established a cause and effect relationship, physicians should be aware that variable effects an blood coagulation have been reported very rarely in patients receiving oral anticoagulants and chlordiazepoxide.
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<anticoagulants, effect, chlordiazepoxide>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Azlocillin should not be administered concomitantly with amikacin, ciprofloxacin, gentamicin, netilmicin, or tobramycin.
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<Azlocillin, advise, amikacin>, <Azlocillin, advise, ciprofloxacin>, <Azlocillin, advise, gentamicin>, <Azlocillin, advise, netilmicin>, <Azlocillin, advise, tobramycin>
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