SkyHuReal/DrugBank-Alpaca · Datasets at Hugging Face

instruction stringclasses 1 value	input stringlengths 42 1.01k	output stringlengths 16 2.12k
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	ZEBETA should not be combined with other beta-blocking agents.	<ZEBETA, advise, beta-blocking agents>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Patients receiving catecholamine-depleting drugs, such as reserpine or guanethidine, should be closely monitored, because the added beta-adrenergic blocking action of ZEBETA may produce excessive reduction of sympathetic activity.	<reserpine, effect, ZEBETA>, <guanethidine, effect, ZEBETA>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	In patients receiving concurrent therapy with clonidine, if therapy is to be discontinued, it is suggested that ZEBETA be discontinued for several days before the withdrawal of clonidine.	<ZEBETA, advise, clonidine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	ZEBETA should be used with care when myocardial depressants or inhibitors of AV conduction, such as certain calcium antagonists (particularly of the phenylalkylamine [verapamil] and benzothiazepine [diltiazem] classes), or antiarrhythmic agents, such as disopyramide, are used concurrently.	<ZEBETA, advise, myocardial depressants>, <ZEBETA, advise, calcium antagonists>, <ZEBETA, advise, phenylalkylamine>, <ZEBETA, advise, verapamil>, <ZEBETA, advise, benzothiazepine>, <ZEBETA, advise, diltiazem>, <ZEBETA, advise, antiarrhythmic agents>, <ZEBETA, advise, disopyramide>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Concurrent use of rifampin increases the metabolic clearance of ZEBETA, resulting in a shortened elimination half-life of ZEBETA.	<rifampin, mechanism, ZEBETA>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Medications can interfere with folate utilization, including: anticonvulsant medications (such as phenytoin, and primidone) metformin (sometimes prescribed to control blood sugar in type 2 diabetes) sulfasalazine (used to control inflammation associated with Crohns disease and ulcerative colitis) triamterene (a diuretic) Methotrexate There has been concern about the interaction between vitamin B12 and folic acid.	<vitamin B12, int, folic acid>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Antacids containing magnesium trisilicate, when administered concomitantly with nitrofurantoin, reduce both the rate and extent of absorption.	<magnesium trisilicate, mechanism, nitrofurantoin>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	The mechanism for this interaction probably is adsorption of nitrofurantoin onto the surface of magnesium trisilicate.	<nitrofurantoin, mechanism, magnesium trisilicate>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Uricosuric drugs, such as probenecid and sulfinpyrazone, can inhibit renal tubular secretion of nitrofurantoin.	<Uricosuric drugs, mechanism, nitrofurantoin>, <probenecid, mechanism, nitrofurantoin>, <sulfinpyrazone, mechanism, nitrofurantoin>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Concurrent administration of drugs possessing nephrotoxic (e.g., aminoglycosides, indomethacin), myelotoxic (e.g., cytotoxic chemotherapy), cardiotoxic (e.g., doxorubicin) or hepatotoxic (e.g., methotrexate, asparaginase) effects with PROLEUKIN may increase toxicity in these organ systems.	<aminoglycosides, effect, PROLEUKIN>, <indomethacin, effect, PROLEUKIN>, <cytotoxic, effect, PROLEUKIN>, <doxorubicin, effect, PROLEUKIN>, <methotrexate, effect, PROLEUKIN>, <asparaginase, effect, PROLEUKIN>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Hypersensitivity reactions have been reported in patients receiving combination regimens containing sequential high dose PROLEUKIN and antineoplastic agents, specifically, dacarbazine, cis-platinum, tamoxifen and interferon-alfa.	<PROLEUKIN, effect, antineoplastic agents>, <PROLEUKIN, effect, dacarbazine>, <PROLEUKIN, effect, cis-platinum>, <PROLEUKIN, effect, tamoxifen>, <PROLEUKIN, effect, interferon-alfa>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Myocardial injury, including myocardial infarction, myocarditis, ventricular hypokinesia, and severe rhabdomyolysis appear to be increased in patients receiving PROLEUKIN and interferon-alfa concurrently.	<PROLEUKIN, effect, interferon-alfa>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Exacerbation or the initial presentation of a number of autoimmune and inflammatory disorders has been observed following concurrent use of interferon-alfa and PROLEUKIN, including crescentic IgA glomerulonephritis, oculo-bulbar myasthenia gravis, inflammatory arthritis, thyroiditis, bullous pemphigoid, and Stevens-Johnson syndrome.	<interferon-alfa, effect, PROLEUKIN>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Although glucocorticoids have been shown to reduce PROLEUKIN-induced side effects including fever, renal insufficiency, hyperbilirubinemia, confusion, and dyspnea, concomitant administration of these agents with PROLEUKIN may reduce the antitumor effectiveness of PROLEUKIN and thus should be avoided. 12 Beta-blockers and other antihypertensives may potentiate the hypotension seen with PROLEUKIN.	<glucocorticoids, effect, PROLEUKIN>, <Beta-blockers, effect, PROLEUKIN>, <antihypertensives, effect, PROLEUKIN>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Delayed Adverse Reactions to Iodinated Contrast Media: A review of the literature revealed that 12.6% (range 11-28%) of 501 patients treated with various interleukin-2 containing regimens who were subsequently administered radiographic iodinated contrast media experienced acute, atypical adverse reactions.	<interleukin-2, effect, radiographic iodinated contrast media>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Cevimeline should be administered with caution to patients taking beta adrenergic antagonists, because of the possibility of conduction disturbances.	<Cevimeline, advise, beta adrenergic antagonists>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Aminosalicylic acid may decrease the amount of digoxin (Lanoxin, Lanoxicaps) that gets absorbed into your body.	<Aminosalicylic acid, mechanism, digoxin>, <Aminosalicylic acid, mechanism, Lanoxin>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	In the case that you are taking digoxin while taking aminosalicylic acid, higher doses of digoxin may be needed.	<digoxin, advise, aminosalicylic acid>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Aminosalicylic acid may also decrease the absorption of vitamin B12, which can lead to a deficiency.	<Aminosalicylic acid, mechanism, vitamin B12>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Therefore you may need to take a vitamin B12 supplement while taking aminosalicylic acid.	<vitamin B12, advise, aminosalicylic acid>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	PROSTIN E2 may augment the activity of other oxytocic drugs.	<PROSTIN E2, effect, oxytocic drugs>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Interactions for vitamin D analogues (Vitamin D2, Vitamin D3, Calcitriol, and Calcidiol): Cholestyramine: Cholestyramine has been reported to reduce intestinal absorption of fat soluble vitamins;	<Cholestyramine, mechanism, fat soluble vitamins>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Phenytoin/Phenobarbital: The coadministration of phenytoin or phenobarbital will not affect plasma concentrations of vitamin D, but may reduce endogenous plasma levels of calcitriol/ergocalcitriol by accelerating metabolism.	<phenytoin, mechanism, calcitriol>, <phenobarbital, mechanism, calcitriol>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Some reports have shown that the concomitant administration of thiazides with vitamin D causes hypercalcemia.	<thiazides, effect, vitamin D>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Digitalis: Vitamin D dosage must be determined with care in patients undergoing treatment with digitalis, as hypercalcemia in such patients may precipitate cardiac arrhythmias.	<Vitamin D, advise, digitalis>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Ketoconazole: Ketoconazole may inhibit both synthetic and catabolic enzymes of vitamin D.	<Ketoconazole, mechanism, vitamin D>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Corticosteroids: A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption.	<vitamin D analogues, mechanism, corticosteroids>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Magnesium: Magnesium-containing preparations (eg, antacids) may cause hypermagnesemia and should therefore not be taken during therapy with vitamin D by patients on chronic renal dialysis.	<Magnesium, advise, vitamin D>, <antacids, advise, vitamin D>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	May interact with the following: cholestyramine, colestipol (use with thiazide diuretics may prevent the diuretic from working properly;	<cholestyramine, effect, thiazide diuretics>, <colestipol, effect, thiazide diuretics>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Other CNS depressant drugs (e.g. barbiturates, tranquilizers, opioids and general anesthetics) have additive or potentiating effects with INAPSINE.	<CNS depressant drugs, effect, INAPSINE>, <barbiturates, effect, INAPSINE>, <tranquilizers, effect, INAPSINE>, <opioids, effect, INAPSINE>, <anesthetics, effect, INAPSINE>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Following the administration of INAPSINE, the dose of other CNS depressant drugs should be reduced.	<INAPSINE, advise, CNS depressant drugs>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Isoproterenol hydrochloride injection and epinephrine should not be administered simultaneously because both drugs are direct cardiac stimulants and their combined effects may induce serious arrhythmias.	<Isoproterenol hydrochloride, advise, epinephrine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	ISUPREL should be used with caution, if at all, when potent inhalational anesthetics such as halothane are employed because of potential to sensitize the myocardium to effects of sympathomimetic amines.	<ISUPREL, advise, anesthetics>, <ISUPREL, advise, halothane>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	The effectiveness of progestin-only pills is reduced by hepatic enzyme-inducing drugs such as the anticonvulsants phenytoin, carbamazepine, and barbiturates, and the antituberculosis drug rifampin.	<progestin, effect, phenytoin>, <progestin, effect, carbamazepine>, <progestin, effect, barbiturates>, <progestin, effect, rifampin>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Concomitant administration of FACTIVE and calcium carbonate, cimetidine, omeprazole, or an estrogen/progesterone oral contraceptive produced minor changes in the pharmacokinetics of gemifloxacin, which were considered to be without clinical significance.	<FACTIVE, mechanism, calcium carbonate>, <FACTIVE, mechanism, cimetidine>, <FACTIVE, mechanism, omeprazole>, <FACTIVE, mechanism, estrogen>, <FACTIVE, mechanism, progesterone>, <FACTIVE, mechanism, contraceptive>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Concomitant administration of FACTIVE with probenecid resulted in a 45% increase in systemic exposure to gemifloxacin.	<FACTIVE, mechanism, probenecid>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	However, because some quinolones have been reported to enhance the anticoagulant effects of warfarin or its derivatives in patients, the prothrombin time or other suitable coagulation test should be closely monitored if a quinolone antimicrobial is administered concomitantly with warfarin or its derivatives.	<quinolones, effect, warfarin>, <quinolone antimicrobial, advise, warfarin>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	The absorption of oral gemifloxacin is significantly reduced by the concomitant administration of an antacid containing aluminum and magnesium.	<gemifloxacin, mechanism, aluminum>, <gemifloxacin, mechanism, magnesium>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Magnesium- and/or aluminum-containing antacids, products containing ferrous sulfate (iron), multivitamin preparations containing zinc or other metal cations, or Videx (didanosine) chewable/buffered tablets or the pediatric powder for oral solution should not be taken within 3 hours before or 2 hours after FACTIVE.	<Magnesium, advise, FACTIVE>, <aluminum, advise, FACTIVE>, <ferrous sulfate, advise, FACTIVE>, <iron, advise, FACTIVE>, <multivitamin preparations, advise, FACTIVE>, <zinc, advise, FACTIVE>, <Videx, advise, FACTIVE>, <didanosine, advise, FACTIVE>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Sucralfate should not be taken within 2 hours of FACTIVE.	<Sucralfate, advise, FACTIVE>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Steroids enhance the renal toxicity of edetate calcium disodium in animals. 7 Edetate calcium disodium interferes with the action of zinc insulin preparations by chelating the zinc. 7	<Steroids, effect, edetate calcium disodium>, <Edetate calcium disodium, mechanism, zinc insulin>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	(Concurrent use with thiazide diuretics may enhance the possibility of digitalis toxicity associated with hypokalemia.)	<thiazide diuretics, effect, digitalis>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	for adult-onset diabetics, dosage adjustment of hypoglycemic medications may be necessary during and after thiazide diuretic therapy;	<hypoglycemic medications, advise, thiazide diuretic>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	(In some patients, the steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium sparing, and thiazide diuretics.	<steroidal anti-inflammatory agent, effect, loop diuretics>, <steroidal anti-inflammatory agent, effect, potassium sparing diuretics>, <steroidal anti-inflammatory agent, effect, thiazide diuretics>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Therefore, when hydroflumethiazide and nonsteroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained.)	<hydroflumethiazide, advise, nonsteroidal anti-inflammatory agents>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	(Thiazides may decrease arterial responsiveness to norepinephrine.	<Thiazides, effect, norepinephrine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	(Thiazide drugs may increase the responsiveness to tubocurarine.)	<Thiazide drugs, effect, tubocurarine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Experience with co-administration of HMG-CoA reductase inhibitors and Fentanyl in patients is limited,therefore,consideration should be given to temporarily suspending use of HMG-CoA reductase inhibitors in patients receiving Fentanyl.	<HMG-CoA reductase inhibitors, advise, Fentanyl>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Acetaminophen and methotrexate - L-methionine may decrease hepatic toxicity in those with acetaminophen overdosage or in those taking methotrexate.	<L-methionine, effect, acetaminophen>, <L-methionine, effect, methotrexate>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Gentamicin - Methionine may protect against the ototoxic effects of gentamicin.	<Methionine, effect, gentamicin>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Although BETAGAN used alone has little or no effect on pupil size, mydriasis resulting from concomitant therapy with BETAGAN and epinephrine may occur.	<BETAGAN, effect, epinephrine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Close observation of the patient is recommended when a beta-blocker is administered to patients receiving catecholamine-depleting drugs such as reserpine, because of possible additive effects and the production of hypotension and/or marked bradycardia, which may produce vertigo, syncope or postural hypotension.	<beta-blocker, advise, reserpine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Patients receiving beta-adrenergic blocking agents along with either oral or intravenous calcium antagonists should be monitored for possible atrioventricular conduction disturbances, left ventricular failure and hypotension.	<beta-adrenergic blocking agents, advise, calcium antagonists>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	The concomitant use of beta-adrenergic blocking agents with digitalis and calcium antagonists may have additive effects on prolonging atrioventricular conduction time.	<beta-adrenergic blocking agents, effect, digitalis>, <beta-adrenergic blocking agents, effect, calcium antagonist>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Phenothiazine-related compounds and beta-adrenergic blocking agents may have additive hypotensite effects due to the inhibition of each other s metabolism.	<Phenothiazine-related compounds, mechanism, beta-adrenergic blocking agents>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	International Normalized Ratio (INR) elevations and/or bleeding events have been reported in some patients taking warfarin while on IRESSA therapy.	<warfarin, effect, IRESSA>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Substances that are potent inhibitors of CYP3A4 activity (eg, ketoconazole and itraconazole) decrease gefitinib metabolism and increase gefitinib plasma concentrations.	<ketoconazole, mechanism, gefitinib>, <ketoconazole, mechanism, gefitinib>, <itraconazole, mechanism, gefitinib>, <itraconazole, mechanism, gefitinib>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Drugs that cause significant sustained elevation in gastric pH (histamine H2-receptor antagonists such as ranitidine or cimetidine) may reduce plasma concentrations of IRESSA and therefore potentially may reduce efficacy.	<histamine H2-receptor antagonists, mechanism, IRESSA>, <ranitidine, mechanism, IRESSA>, <cimetidine, mechanism, IRESSA>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Phase II clinical trial data, where IRESSA and vinorelbine have been used concomitantly, indicate that IRESSA may exacerbate the neutropenic effect of vinorelbine.	<IRESSA, effect, vinorelbine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	There have been rare reports of significant respiratory depression, stupor and/or hypotension with the concomitant use of loxapine and lorazepam.	<loxapine, effect, lorazepam>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Drugs that may alter imatinib plasma concentrations Drugs that may increase imatinib plasma concentrations: Caution is recommended when administering Gleevec with inhibitors of the CYP3A4 family (e.g., ketoconazole, itraconazole, erythromycin, clarithromycin).	<Gleevec, advise, ketoconazole>, <Gleevec, advise, itraconazole>, <Gleevec, advise, erythromycin>, <Gleevec, advise, clarithromycin>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	There is a significant increase in exposure to imatinib when Gleevec is coadministered with ketoconazole (CYP3A4 inhibitor).	<Gleevec, mechanism, ketoconazole>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Pretreatment of healthy volunteers with multiple doses of rifampin followed by a single dose of Gleevec, increased Gleevec oral-dose clearance by 3.8-fold, which significantly (p 0.05) decreased mean cmax and AUC(0-8).	<rifampin, mechanism, Gleevec>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Drugs that may have their plasma concentration altered by Gleevec Gleevec increases the mean cmax and AUC of simvastatin (CYP3A4 substrate) 2- and 3.5-fold, respectively, suggesting an inhibition of the CYP3A4 by Gleevec.	<Gleevec, mechanism, simvastatin>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Particular caution is recommended when administering Gleevec with CYP3A4 substrates that have a narrow therapeutic window (e.g., cyclosporine or pimozide).	<Gleevec, advise, cyclosporine>, <Gleevec, advise, pimozide>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Gleevec will increase plasmaconcentration of other CYP3A4 metabolized drugs (e.g., triazolo-benzodiazepines, dihydropyridine calcium channel blockers, certain HMG-CoA reductase inhibitors, etc.).	<Gleevec, mechanism, benzodiazepines>, <Gleevec, mechanism, dihydropyridine calcium channel blockers>, <Gleevec, mechanism, HMG-CoA reductase inhibitors>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Systemic exposure to acetaminophen is expected to be increased when coadministered with Gleevec.	<acetaminophen, mechanism, Gleevec>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	A possible drug interaction of FOSCAVIR and intravenous pentamidine has been described.	<FOSCAVIR, int, pentamidine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Concomitant treatment of four patients in the United Kingdom with FOSCAVIR and intravenous pentamidine may have caused hypocalcemia;	<FOSCAVIR, effect, pentamidine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Because of foscarnets tendency to cause renal impairment, the use of FOSCAVIR should be avoided in combination with potentially nephrotoxic drugs such as aminoglycosides, amphotericin B and intravenous pentamidine unless the potential benefits outweigh the risks to the patient.	<FOSCAVIR, advise, aminoglycosides>, <FOSCAVIR, advise, amphotericin B>, <FOSCAVIR, advise, pentamidine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Because there is a theoretical basis that these effects may be additive, use of ergotamine-containing or ergot-type medications (like dihydroergotamine or methysergide) and naratriptan within 24 hours is contraindicated.	<ergotamine, advise, naratriptan>, <ergot-type medications, advise, naratriptan>, <dihydroergotamine, advise, naratriptan>, <methysergide, advise, naratriptan>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Because their vasospastic effects may be additive, coadministration of naratriptan and other 5-HT1 agonists within 24 hours of each other is not recommended.	<naratriptan, advise, 5-HT1 agonists>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	If concomitant treatment with naratriptan and an SSRI is clinically warranted, appropriate observation of the patient is advised.	<naratriptan, advise, SSRI>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Cimetidine at 400 mg BID (the usual prescription dose) co-administered with TIKOSYN (500 mcg BID) for 7 days has been shown to increase dofetilide plasma levels by 58%.	<Cimetidine, mechanism, TIKOSYN>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Cimetidine at doses of 100 mg BID (OTC dose) resulted in a 13% increase in dofetilide plasma levels (500 mcg single dose).	<Cimetidine, mechanism, dofetilide>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	If a patient requires TIKOSYN and anti-ulcer therapy, it is suggested that omeprazole, ranitidine, or antacids (aluminum and magnesium hydroxides) be used as alternatives to cimetidine, as these agents have no effect on the pharmacokinetic profile of TIKOSYN.	<TIKOSYN, advise, cimetidine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Co-administration of TIKOSYN with verapamil resulted in increases in dofetilide peak plasma levels of 42%, although overall exposure to dofetilide was not significantly increased.	<TIKOSYN, mechanism, verapamil>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	In an analysis of the supraventricular arrhythmia and DIAMOND patient populations, the concomitant administration of verapamil with dofetilide was associated with a higher occurrence of torsade de pointes.	<verapamil, effect, dofetilide>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Ketoconazole at 400 mg daily (the maximum approved prescription dose) co-administered with TIKOSYN (500 mcg BID) for 7 days has been shown to increase dofetilide Cmax by 53% in males and 97% in females, and AUC by 41% in males and 69% in females.	<Ketoconazole, mechanism, TIKOSYN>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	In patients receiving HCTZ alone, dofetilide AUC increased by 27% and Cmax by 21%.	<HCTZ, mechanism, dofetilide>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	In addition, drugs that are actively secreted via this route (e.g., triamterene, metformin and amiloride) should be co-administered with care as they might increase dofetilide levels.	<triamterene, advise, dofetilide>, <metformin, advise, dofetilide>, <amiloride, advise, dofetilide>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Inhibitors of this isoenzyme (e.g., macrolide antibiotics, azole antifungal agents, protease inhibitors, serotonin reuptake inhibitors, amiodarone, cannabinoids, diltiazem, grapefruit juice, nefazadone, norfloxacin, quinine, zafirlukast) should be cautiously coadministered with TIKOSYN as they can potentially increase dofetilide levels.	<macrolide antibiotics, advise, TIKOSYN>, <azole antifungal agents, advise, TIKOSYN>, <protease inhibitors, advise, TIKOSYN>, <serotonin reuptake inhibitors, advise, TIKOSYN>, <amiodarone, advise, TIKOSYN>, <cannabinoids, advise, TIKOSYN>, <diltiazem, advise, TIKOSYN>, <nefazadone, advise, TIKOSYN>, <norfloxacin, advise, TIKOSYN>, <quinine, advise, TIKOSYN>, <zafirlukast, advise, TIKOSYN>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	In patients, the concomitant administration of digoxin with dofetilide was associated with a higher occurrence of torsade de pointes.	<digoxin, effect, dofetilide>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	The mean clearances of dofetilide were 16% and 15% lower in patients on thiazide diuretics and inhibitors of tubular organic cation transport, respectively.	<dofetilide, mechanism, thiazide diuretics>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Intravenous ranitidine was shown to double the bioavailability of oral alendronate.	<ranitidine, mechanism, alendronate>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Products containing calcium and other multivalent cations likely will interfere with absorption of alendronate.	<calcium, mechanism, alendronate>, <multivalent cations, mechanism, alendronate>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Clinical studies with celecoxib have identified potentially significant interactions with fluconazole and lithium.	<celecoxib, int, fluconazole>, <celecoxib, int, lithium>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Experience with nonsteroidal anti-inflammatory drugs (NSAIDs) suggests the potential for interactions with furosemide and ACE inhibitors.	<nonsteroidal anti-inflammatory drugs, int, furosemide>, <nonsteroidal anti-inflammatory drugs, int, ACE inhibitors>, <NSAIDs, int, furosemide>, <NSAIDs, int, ACE inhibitors>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	ACE inhibitors: Reports suggest that NSAIDs may diminish the antihypertensive effect of Angiotensin Converting Enzyme (ACE) inhibitors.	<NSAIDs, effect, Angiotensin Converting Enzyme (ACE) inhibitors>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	This interaction should be given consideration in patients taking CELEBREX concomitantly with ACE-inhibitors.	<CELEBREX, advise, ACE-inhibitors>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Furosemide: Clinical studies, as well as post marketing observations, have shown that NSAIDs can reduce the natriuretic effect of furosemide and thiazides in some patients.	<NSAIDs, effect, furosemide>, <NSAIDs, effect, thiazides>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Aspirin: CELEBREX can be used with low dose aspirin.	<CELEBREX, advise, aspirin>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	However, concomitant administration of aspirin with CELEBREX may result in an increased rate of GI ulceration or other complications, compared to use of CELEBREX alone.	<aspirin, effect, CELEBREX>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Fluconazole: Concomitant administration of fluconazole at 200 mg QD resulted in a two-fold increase in celecoxib plasma concentration.	<fluconazole, mechanism, celecoxib>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	This increase is due to the inhibition of celecoxib metabolism via P450 2C9 by fluconazole (see CLINICAL PHARMACOLOGY - Pharmacokinetics: Metabolism).	<celecoxib, mechanism, fluconazole>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	CELEBREX should be introduced at the lowest recommended dose in patients receiving fluconazole.	<CELEBREX, advise, fluconazole>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Lithium: In a study conducted in healthy subjects, mean steady-state lithium plasma levels increased approximately 17% in subjects receiving lithium 450 mg BID with CELEBREX 200 mg BID as compared to subjects receiving lithium alone.	<lithium, mechanism, CELEBREX>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Patients on lithium treatment should be closely monitored when CELEBREX is introduced or withdrawn.	<lithium, advise, CELEBREX>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	However, caution should be used when administering CELEBREX with warfarin since these patients are at increased risk of bleeding complications.	<CELEBREX, advise, warfarin>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.	Medroxyprogesterone Acetate - L-histidine was observed to enhance (in tissue culture) the effect of medroxyprogesterone acetate in reducing the number of human breast cancer cells that were in the S phase.	<L-histidine, effect, medroxyprogesterone acetate>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

ZEBETA should not be combined with other beta-blocking agents.

<ZEBETA, advise, beta-blocking agents>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Patients receiving catecholamine-depleting drugs, such as reserpine or guanethidine, should be closely monitored, because the added beta-adrenergic blocking action of ZEBETA may produce excessive reduction of sympathetic activity.

<reserpine, effect, ZEBETA>, <guanethidine, effect, ZEBETA>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

In patients receiving concurrent therapy with clonidine, if therapy is to be discontinued, it is suggested that ZEBETA be discontinued for several days before the withdrawal of clonidine.

<ZEBETA, advise, clonidine>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

ZEBETA should be used with care when myocardial depressants or inhibitors of AV conduction, such as certain calcium antagonists (particularly of the phenylalkylamine [verapamil] and benzothiazepine [diltiazem] classes), or antiarrhythmic agents, such as disopyramide, are used concurrently.

<ZEBETA, advise, myocardial depressants>, <ZEBETA, advise, calcium antagonists>, <ZEBETA, advise, phenylalkylamine>, <ZEBETA, advise, verapamil>, <ZEBETA, advise, benzothiazepine>, <ZEBETA, advise, diltiazem>, <ZEBETA, advise, antiarrhythmic agents>, <ZEBETA, advise, disopyramide>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Concurrent use of rifampin increases the metabolic clearance of ZEBETA, resulting in a shortened elimination half-life of ZEBETA.

<rifampin, mechanism, ZEBETA>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Medications can interfere with folate utilization, including: anticonvulsant medications (such as phenytoin, and primidone) metformin (sometimes prescribed to control blood sugar in type 2 diabetes) sulfasalazine (used to control inflammation associated with Crohns disease and ulcerative colitis) triamterene (a diuretic) Methotrexate There has been concern about the interaction between vitamin B12 and folic acid.

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Antacids containing magnesium trisilicate, when administered concomitantly with nitrofurantoin, reduce both the rate and extent of absorption.

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

The mechanism for this interaction probably is adsorption of nitrofurantoin onto the surface of magnesium trisilicate.

<nitrofurantoin, mechanism, magnesium trisilicate>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Uricosuric drugs, such as probenecid and sulfinpyrazone, can inhibit renal tubular secretion of nitrofurantoin.

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Concurrent administration of drugs possessing nephrotoxic (e.g., aminoglycosides, indomethacin), myelotoxic (e.g., cytotoxic chemotherapy), cardiotoxic (e.g., doxorubicin) or hepatotoxic (e.g., methotrexate, asparaginase) effects with PROLEUKIN may increase toxicity in these organ systems.

<aminoglycosides, effect, PROLEUKIN>, <indomethacin, effect, PROLEUKIN>, <cytotoxic, effect, PROLEUKIN>, <doxorubicin, effect, PROLEUKIN>, <methotrexate, effect, PROLEUKIN>, <asparaginase, effect, PROLEUKIN>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Hypersensitivity reactions have been reported in patients receiving combination regimens containing sequential high dose PROLEUKIN and antineoplastic agents, specifically, dacarbazine, cis-platinum, tamoxifen and interferon-alfa.

<PROLEUKIN, effect, antineoplastic agents>, <PROLEUKIN, effect, dacarbazine>, <PROLEUKIN, effect, cis-platinum>, <PROLEUKIN, effect, tamoxifen>, <PROLEUKIN, effect, interferon-alfa>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Myocardial injury, including myocardial infarction, myocarditis, ventricular hypokinesia, and severe rhabdomyolysis appear to be increased in patients receiving PROLEUKIN and interferon-alfa concurrently.

<PROLEUKIN, effect, interferon-alfa>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Exacerbation or the initial presentation of a number of autoimmune and inflammatory disorders has been observed following concurrent use of interferon-alfa and PROLEUKIN, including crescentic IgA glomerulonephritis, oculo-bulbar myasthenia gravis, inflammatory arthritis, thyroiditis, bullous pemphigoid, and Stevens-Johnson syndrome.

<interferon-alfa, effect, PROLEUKIN>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Although glucocorticoids have been shown to reduce PROLEUKIN-induced side effects including fever, renal insufficiency, hyperbilirubinemia, confusion, and dyspnea, concomitant administration of these agents with PROLEUKIN may reduce the antitumor effectiveness of PROLEUKIN and thus should be avoided. 12 Beta-blockers and other antihypertensives may potentiate the hypotension seen with PROLEUKIN.

<glucocorticoids, effect, PROLEUKIN>, <Beta-blockers, effect, PROLEUKIN>, <antihypertensives, effect, PROLEUKIN>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Delayed Adverse Reactions to Iodinated Contrast Media: A review of the literature revealed that 12.6% (range 11-28%) of 501 patients treated with various interleukin-2 containing regimens who were subsequently administered radiographic iodinated contrast media experienced acute, atypical adverse reactions.

<interleukin-2, effect, radiographic iodinated contrast media>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Cevimeline should be administered with caution to patients taking beta adrenergic antagonists, because of the possibility of conduction disturbances.

<Cevimeline, advise, beta adrenergic antagonists>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Aminosalicylic acid may decrease the amount of digoxin (Lanoxin, Lanoxicaps) that gets absorbed into your body.

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

In the case that you are taking digoxin while taking aminosalicylic acid, higher doses of digoxin may be needed.

<digoxin, advise, aminosalicylic acid>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Aminosalicylic acid may also decrease the absorption of vitamin B12, which can lead to a deficiency.

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Therefore you may need to take a vitamin B12 supplement while taking aminosalicylic acid.

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

PROSTIN E2 may augment the activity of other oxytocic drugs.

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Interactions for vitamin D analogues (Vitamin D2, Vitamin D3, Calcitriol, and Calcidiol): Cholestyramine: Cholestyramine has been reported to reduce intestinal absorption of fat soluble vitamins;

<Cholestyramine, mechanism, fat soluble vitamins>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Phenytoin/Phenobarbital: The coadministration of phenytoin or phenobarbital will not affect plasma concentrations of vitamin D, but may reduce endogenous plasma levels of calcitriol/ergocalcitriol by accelerating metabolism.

<phenytoin, mechanism, calcitriol>, <phenobarbital, mechanism, calcitriol>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Some reports have shown that the concomitant administration of thiazides with vitamin D causes hypercalcemia.

<thiazides, effect, vitamin D>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Digitalis: Vitamin D dosage must be determined with care in patients undergoing treatment with digitalis, as hypercalcemia in such patients may precipitate cardiac arrhythmias.

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Ketoconazole: Ketoconazole may inhibit both synthetic and catabolic enzymes of vitamin D.

<Ketoconazole, mechanism, vitamin D>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Corticosteroids: A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption.

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Magnesium: Magnesium-containing preparations (eg, antacids) may cause hypermagnesemia and should therefore not be taken during therapy with vitamin D by patients on chronic renal dialysis.

<Magnesium, advise, vitamin D>, <antacids, advise, vitamin D>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

May interact with the following: cholestyramine, colestipol (use with thiazide diuretics may prevent the diuretic from working properly;

<cholestyramine, effect, thiazide diuretics>, <colestipol, effect, thiazide diuretics>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Other CNS depressant drugs (e.g. barbiturates, tranquilizers, opioids and general anesthetics) have additive or potentiating effects with INAPSINE.

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Following the administration of INAPSINE, the dose of other CNS depressant drugs should be reduced.

<INAPSINE, advise, CNS depressant drugs>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Isoproterenol hydrochloride injection and epinephrine should not be administered simultaneously because both drugs are direct cardiac stimulants and their combined effects may induce serious arrhythmias.

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

ISUPREL should be used with caution, if at all, when potent inhalational anesthetics such as halothane are employed because of potential to sensitize the myocardium to effects of sympathomimetic amines.

<ISUPREL, advise, anesthetics>, <ISUPREL, advise, halothane>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

The effectiveness of progestin-only pills is reduced by hepatic enzyme-inducing drugs such as the anticonvulsants phenytoin, carbamazepine, and barbiturates, and the antituberculosis drug rifampin.

<progestin, effect, phenytoin>, <progestin, effect, carbamazepine>, <progestin, effect, barbiturates>, <progestin, effect, rifampin>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Concomitant administration of FACTIVE and calcium carbonate, cimetidine, omeprazole, or an estrogen/progesterone oral contraceptive produced minor changes in the pharmacokinetics of gemifloxacin, which were considered to be without clinical significance.

<FACTIVE, mechanism, calcium carbonate>, <FACTIVE, mechanism, cimetidine>, <FACTIVE, mechanism, omeprazole>, <FACTIVE, mechanism, estrogen>, <FACTIVE, mechanism, progesterone>, <FACTIVE, mechanism, contraceptive>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Concomitant administration of FACTIVE with probenecid resulted in a 45% increase in systemic exposure to gemifloxacin.

<FACTIVE, mechanism, probenecid>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

However, because some quinolones have been reported to enhance the anticoagulant effects of warfarin or its derivatives in patients, the prothrombin time or other suitable coagulation test should be closely monitored if a quinolone antimicrobial is administered concomitantly with warfarin or its derivatives.

<quinolones, effect, warfarin>, <quinolone antimicrobial, advise, warfarin>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

The absorption of oral gemifloxacin is significantly reduced by the concomitant administration of an antacid containing aluminum and magnesium.

<gemifloxacin, mechanism, aluminum>, <gemifloxacin, mechanism, magnesium>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Magnesium- and/or aluminum-containing antacids, products containing ferrous sulfate (iron), multivitamin preparations containing zinc or other metal cations, or Videx (didanosine) chewable/buffered tablets or the pediatric powder for oral solution should not be taken within 3 hours before or 2 hours after FACTIVE.

<Magnesium, advise, FACTIVE>, <aluminum, advise, FACTIVE>, <ferrous sulfate, advise, FACTIVE>, <iron, advise, FACTIVE>, <multivitamin preparations, advise, FACTIVE>, <zinc, advise, FACTIVE>, <Videx, advise, FACTIVE>, <didanosine, advise, FACTIVE>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Sucralfate should not be taken within 2 hours of FACTIVE.

<Sucralfate, advise, FACTIVE>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Steroids enhance the renal toxicity of edetate calcium disodium in animals. 7 Edetate calcium disodium interferes with the action of zinc insulin preparations by chelating the zinc. 7

<Steroids, effect, edetate calcium disodium>, <Edetate calcium disodium, mechanism, zinc insulin>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

(Concurrent use with thiazide diuretics may enhance the possibility of digitalis toxicity associated with hypokalemia.)

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

for adult-onset diabetics, dosage adjustment of hypoglycemic medications may be necessary during and after thiazide diuretic therapy;

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

(In some patients, the steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium sparing, and thiazide diuretics.

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Therefore, when hydroflumethiazide and nonsteroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained.)

<hydroflumethiazide, advise, nonsteroidal anti-inflammatory agents>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

(Thiazides may decrease arterial responsiveness to norepinephrine.

<Thiazides, effect, norepinephrine>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

(Thiazide drugs may increase the responsiveness to tubocurarine.)

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Experience with co-administration of HMG-CoA reductase inhibitors and Fentanyl in patients is limited,therefore,consideration should be given to temporarily suspending use of HMG-CoA reductase inhibitors in patients receiving Fentanyl.

<HMG-CoA reductase inhibitors, advise, Fentanyl>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Acetaminophen and methotrexate - L-methionine may decrease hepatic toxicity in those with acetaminophen overdosage or in those taking methotrexate.

<L-methionine, effect, acetaminophen>, <L-methionine, effect, methotrexate>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Gentamicin - Methionine may protect against the ototoxic effects of gentamicin.

<Methionine, effect, gentamicin>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Although BETAGAN used alone has little or no effect on pupil size, mydriasis resulting from concomitant therapy with BETAGAN and epinephrine may occur.

<BETAGAN, effect, epinephrine>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Close observation of the patient is recommended when a beta-blocker is administered to patients receiving catecholamine-depleting drugs such as reserpine, because of possible additive effects and the production of hypotension and/or marked bradycardia, which may produce vertigo, syncope or postural hypotension.

<beta-blocker, advise, reserpine>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Patients receiving beta-adrenergic blocking agents along with either oral or intravenous calcium antagonists should be monitored for possible atrioventricular conduction disturbances, left ventricular failure and hypotension.

<beta-adrenergic blocking agents, advise, calcium antagonists>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

The concomitant use of beta-adrenergic blocking agents with digitalis and calcium antagonists may have additive effects on prolonging atrioventricular conduction time.

<beta-adrenergic blocking agents, effect, digitalis>, <beta-adrenergic blocking agents, effect, calcium antagonist>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Phenothiazine-related compounds and beta-adrenergic blocking agents may have additive hypotensite effects due to the inhibition of each other s metabolism.

<Phenothiazine-related compounds, mechanism, beta-adrenergic blocking agents>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

International Normalized Ratio (INR) elevations and/or bleeding events have been reported in some patients taking warfarin while on IRESSA therapy.

<warfarin, effect, IRESSA>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Substances that are potent inhibitors of CYP3A4 activity (eg, ketoconazole and itraconazole) decrease gefitinib metabolism and increase gefitinib plasma concentrations.

<ketoconazole, mechanism, gefitinib>, <ketoconazole, mechanism, gefitinib>, <itraconazole, mechanism, gefitinib>, <itraconazole, mechanism, gefitinib>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Drugs that cause significant sustained elevation in gastric pH (histamine H2-receptor antagonists such as ranitidine or cimetidine) may reduce plasma concentrations of IRESSA and therefore potentially may reduce efficacy.

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Phase II clinical trial data, where IRESSA and vinorelbine have been used concomitantly, indicate that IRESSA may exacerbate the neutropenic effect of vinorelbine.

<IRESSA, effect, vinorelbine>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

There have been rare reports of significant respiratory depression, stupor and/or hypotension with the concomitant use of loxapine and lorazepam.

<loxapine, effect, lorazepam>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Drugs that may alter imatinib plasma concentrations Drugs that may increase imatinib plasma concentrations: Caution is recommended when administering Gleevec with inhibitors of the CYP3A4 family (e.g., ketoconazole, itraconazole, erythromycin, clarithromycin).

<Gleevec, advise, ketoconazole>, <Gleevec, advise, itraconazole>, <Gleevec, advise, erythromycin>, <Gleevec, advise, clarithromycin>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

There is a significant increase in exposure to imatinib when Gleevec is coadministered with ketoconazole (CYP3A4 inhibitor).

<Gleevec, mechanism, ketoconazole>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Pretreatment of healthy volunteers with multiple doses of rifampin followed by a single dose of Gleevec, increased Gleevec oral-dose clearance by 3.8-fold, which significantly (p 0.05) decreased mean cmax and AUC(0-8).

<rifampin, mechanism, Gleevec>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Drugs that may have their plasma concentration altered by Gleevec Gleevec increases the mean cmax and AUC of simvastatin (CYP3A4 substrate) 2- and 3.5-fold, respectively, suggesting an inhibition of the CYP3A4 by Gleevec.

<Gleevec, mechanism, simvastatin>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Particular caution is recommended when administering Gleevec with CYP3A4 substrates that have a narrow therapeutic window (e.g., cyclosporine or pimozide).

<Gleevec, advise, cyclosporine>, <Gleevec, advise, pimozide>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Gleevec will increase plasmaconcentration of other CYP3A4 metabolized drugs (e.g., triazolo-benzodiazepines, dihydropyridine calcium channel blockers, certain HMG-CoA reductase inhibitors, etc.).

<Gleevec, mechanism, benzodiazepines>, <Gleevec, mechanism, dihydropyridine calcium channel blockers>, <Gleevec, mechanism, HMG-CoA reductase inhibitors>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Systemic exposure to acetaminophen is expected to be increased when coadministered with Gleevec.

<acetaminophen, mechanism, Gleevec>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

A possible drug interaction of FOSCAVIR and intravenous pentamidine has been described.

<FOSCAVIR, int, pentamidine>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Concomitant treatment of four patients in the United Kingdom with FOSCAVIR and intravenous pentamidine may have caused hypocalcemia;

<FOSCAVIR, effect, pentamidine>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Because of foscarnets tendency to cause renal impairment, the use of FOSCAVIR should be avoided in combination with potentially nephrotoxic drugs such as aminoglycosides, amphotericin B and intravenous pentamidine unless the potential benefits outweigh the risks to the patient.

<FOSCAVIR, advise, aminoglycosides>, <FOSCAVIR, advise, amphotericin B>, <FOSCAVIR, advise, pentamidine>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Because there is a theoretical basis that these effects may be additive, use of ergotamine-containing or ergot-type medications (like dihydroergotamine or methysergide) and naratriptan within 24 hours is contraindicated.

<ergotamine, advise, naratriptan>, <ergot-type medications, advise, naratriptan>, <dihydroergotamine, advise, naratriptan>, <methysergide, advise, naratriptan>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Because their vasospastic effects may be additive, coadministration of naratriptan and other 5-HT1 agonists within 24 hours of each other is not recommended.

<naratriptan, advise, 5-HT1 agonists>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

If concomitant treatment with naratriptan and an SSRI is clinically warranted, appropriate observation of the patient is advised.

<naratriptan, advise, SSRI>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Cimetidine at 400 mg BID (the usual prescription dose) co-administered with TIKOSYN (500 mcg BID) for 7 days has been shown to increase dofetilide plasma levels by 58%.

<Cimetidine, mechanism, TIKOSYN>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Cimetidine at doses of 100 mg BID (OTC dose) resulted in a 13% increase in dofetilide plasma levels (500 mcg single dose).

<Cimetidine, mechanism, dofetilide>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

If a patient requires TIKOSYN and anti-ulcer therapy, it is suggested that omeprazole, ranitidine, or antacids (aluminum and magnesium hydroxides) be used as alternatives to cimetidine, as these agents have no effect on the pharmacokinetic profile of TIKOSYN.

<TIKOSYN, advise, cimetidine>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Co-administration of TIKOSYN with verapamil resulted in increases in dofetilide peak plasma levels of 42%, although overall exposure to dofetilide was not significantly increased.

<TIKOSYN, mechanism, verapamil>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

In an analysis of the supraventricular arrhythmia and DIAMOND patient populations, the concomitant administration of verapamil with dofetilide was associated with a higher occurrence of torsade de pointes.

<verapamil, effect, dofetilide>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Ketoconazole at 400 mg daily (the maximum approved prescription dose) co-administered with TIKOSYN (500 mcg BID) for 7 days has been shown to increase dofetilide Cmax by 53% in males and 97% in females, and AUC by 41% in males and 69% in females.

<Ketoconazole, mechanism, TIKOSYN>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

In patients receiving HCTZ alone, dofetilide AUC increased by 27% and Cmax by 21%.

<HCTZ, mechanism, dofetilide>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

In addition, drugs that are actively secreted via this route (e.g., triamterene, metformin and amiloride) should be co-administered with care as they might increase dofetilide levels.

<triamterene, advise, dofetilide>, <metformin, advise, dofetilide>, <amiloride, advise, dofetilide>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Inhibitors of this isoenzyme (e.g., macrolide antibiotics, azole antifungal agents, protease inhibitors, serotonin reuptake inhibitors, amiodarone, cannabinoids, diltiazem, grapefruit juice, nefazadone, norfloxacin, quinine, zafirlukast) should be cautiously coadministered with TIKOSYN as they can potentially increase dofetilide levels.

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

In patients, the concomitant administration of digoxin with dofetilide was associated with a higher occurrence of torsade de pointes.

<digoxin, effect, dofetilide>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

The mean clearances of dofetilide were 16% and 15% lower in patients on thiazide diuretics and inhibitors of tubular organic cation transport, respectively.

<dofetilide, mechanism, thiazide diuretics>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Intravenous ranitidine was shown to double the bioavailability of oral alendronate.

<ranitidine, mechanism, alendronate>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Products containing calcium and other multivalent cations likely will interfere with absorption of alendronate.

<calcium, mechanism, alendronate>, <multivalent cations, mechanism, alendronate>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Clinical studies with celecoxib have identified potentially significant interactions with fluconazole and lithium.

<celecoxib, int, fluconazole>, <celecoxib, int, lithium>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Experience with nonsteroidal anti-inflammatory drugs (NSAIDs) suggests the potential for interactions with furosemide and ACE inhibitors.

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

ACE inhibitors: Reports suggest that NSAIDs may diminish the antihypertensive effect of Angiotensin Converting Enzyme (ACE) inhibitors.

<NSAIDs, effect, Angiotensin Converting Enzyme (ACE) inhibitors>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

This interaction should be given consideration in patients taking CELEBREX concomitantly with ACE-inhibitors.

<CELEBREX, advise, ACE-inhibitors>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Furosemide: Clinical studies, as well as post marketing observations, have shown that NSAIDs can reduce the natriuretic effect of furosemide and thiazides in some patients.

<NSAIDs, effect, furosemide>, <NSAIDs, effect, thiazides>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Aspirin: CELEBREX can be used with low dose aspirin.

<CELEBREX, advise, aspirin>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

However, concomitant administration of aspirin with CELEBREX may result in an increased rate of GI ulceration or other complications, compared to use of CELEBREX alone.

<aspirin, effect, CELEBREX>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Fluconazole: Concomitant administration of fluconazole at 200 mg QD resulted in a two-fold increase in celecoxib plasma concentration.

<fluconazole, mechanism, celecoxib>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

This increase is due to the inhibition of celecoxib metabolism via P450 2C9 by fluconazole (see CLINICAL PHARMACOLOGY - Pharmacokinetics: Metabolism).

<celecoxib, mechanism, fluconazole>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

CELEBREX should be introduced at the lowest recommended dose in patients receiving fluconazole.

<CELEBREX, advise, fluconazole>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Lithium: In a study conducted in healthy subjects, mean steady-state lithium plasma levels increased approximately 17% in subjects receiving lithium 450 mg BID with CELEBREX 200 mg BID as compared to subjects receiving lithium alone.

<lithium, mechanism, CELEBREX>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Patients on lithium treatment should be closely monitored when CELEBREX is introduced or withdrawn.

<lithium, advise, CELEBREX>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

However, caution should be used when administering CELEBREX with warfarin since these patients are at increased risk of bleeding complications.

<CELEBREX, advise, warfarin>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Medroxyprogesterone Acetate - L-histidine was observed to enhance (in tissue culture) the effect of medroxyprogesterone acetate in reducing the number of human breast cancer cells that were in the S phase.

<L-histidine, effect, medroxyprogesterone acetate>