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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE inhibitors. | <NSAIDs, advise, ACE inhibitors> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Agents Increasing Serum Potassium: Enalapril and enalapril IV attenuate potassium loss caused by thiazide-type diuretics. | <Enalapril, effect, thiazide-type diuretics>, <enalapril, effect, thiazide-type diuretics> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Lithium: Lithium toxicity has been reported in patients receiving lithium concomitantly with drugs which cause elimination of sodium, including ACE inhibitors. | <lithium, effect, ACE inhibitors> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | It is recommended that serum lithium levels be monitored frequently if enalapril is administered concomitantly with lithium. | <enalapril, advise, lithium> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Colchicine para-aminosalicylic acid and heavy alcohol intake for longer than 2 weeks may produce malabsorption of vitamin B12. | <Colchicine, mechanism, vitamin B12>, <para-aminosalicylic acid, mechanism, vitamin B12>, <alcohol, mechanism, vitamin B12> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Uricosuric Agents: Aspirin may decrease the effects of probenecid, sulfinpyrazone, and phenylbutazone. | <Aspirin, effect, probenecid>, <Aspirin, effect, sulfinpyrazone>, <Aspirin, effect, phenylbutazone> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Alcohol: Has a synergistic effect with aspirin in causing gastrointestinal bleeding. | <Alcohol, effect, aspirin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Corticosteroids: Concomitant administration with aspirin may increase the risk of gastrointestinal ulceration and may reduce serum salicylate levels. | <Corticosteroids, effect, aspirin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Pyrazolone Derivatives (phenylbutazone, oxyphenbutazone, and possibly dipyrone): Concomitant administration with aspirin may increase the risk of gastrointestinal ulceration. | <Pyrazolone Derivatives, effect, aspirin>, <phenylbutazone, effect, aspirin>, <oxyphenbutazone, effect, aspirin>, <dipyrone, effect, aspirin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Nonsteroidal Antiinflammatory Agents: Aspirin is contraindicated in patients who are hypersensitive to nonsteroidal anti-inflammatory agents. | <Aspirin, advise, nonsteroidal anti-inflammatory> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Phenobarbital: Decreases aspirin effectiveness by enzyme induction. | <Phenobarbital, mechanism, aspirin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Phenytoin: Serum phenytoin levels may be increased by aspirin. | <phenytoin, effect, aspirin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Propranolol: May decrease aspirins anti-inflammatory action by competing for the same receptors. | <Propranolol, effect, aspirins> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Antacids: Enteric Coated Aspirin should not be given concurrently with antacids, since an increase in the pH of the stomach may effect the enteric coating of the tablets. | <Aspirin, advise, antacids> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | conversely, diethylpropion may interfere with antihypertensive drugs (i.e., guanethidine, a-methyldopa). | <diethylpropion, int, antihypertensive drugs>, <diethylpropion, int, guanethidine>, <diethylpropion, int, a-methyldopa> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Concurrent use of phenothiazines may antagonize the anorectic effect of diethylpropion. | <phenothiazines, effect, diethylpropion> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Concomitant use of SPRYCEL and drugs that inhibit CYP3A4 (eg, ketoconazole, itraconazole, erythromycin, clarithromycin, ritonavir, atazanavir, indinavir, nefazodone, nelfinavir, saquinavir, telithromycin) may increase exposure to dasatinib and should be avoided. | <SPRYCEL, mechanism, ketoconazole>, <SPRYCEL, mechanism, itraconazole>, <SPRYCEL, mechanism, erythromycin>, <SPRYCEL, mechanism, clarithromycin>, <SPRYCEL, mechanism, ritonavir>, <SPRYCEL, mechanism, atazanavir>, <SPRYCEL, mechanism, indinavir>, <SPRYCEL, mechanism, nefazodone>, <SPRYCEL, mechanism, nelfinavir>, <SPRYCEL, mechanism, saquinavir>, <SPRYCEL, mechanism, telithromycin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Simultaneous administration of SPRYCEL with antacids should be avoided. | <SPRYCEL, advise, antacids> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | If antacid therapy is needed, the antacid dose should be administered at least 2 hours prior to or 2 hours after the dose of SPRYCEL. | <antacid, advise, SPRYCEL> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | H2 Blockers/Proton Pump Inhibitors: Long-term suppression of gastric acid secretion by H2 blockers or proton pump inhibitors (eg, famotidine and omeprazole) is likely to reduce dasatinib exposure. | <H2 blockers, effect, dasatinib>, <proton pump inhibitors, effect, dasatinib>, <famotidine, effect, dasatinib>, <omeprazole, effect, dasatinib> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The concomitant use of H2 blockers or proton pump inhibitors with SPRYCEL is not recommended. | <H2 blockers, advise, SPRYCEL>, <proton pump inhibitors, advise, SPRYCEL> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The use of antacids should be considered in place of H2 blockers or proton pump inhibitors in patients receiving SPRYCEL therapy. | <H2 blockers, advise, SPRYCEL>, <proton pump inhibitors, advise, SPRYCEL> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Therefore, CYP3A4 substrates known to have a narrow therapeutic index such as alfentanil, astemizole, terfenadine, cisapride, cyclosporine, fentanyl, pimozide, quinidine, sirolimus, tacrolimus, or ergot alkaloids (ergotamine, dihydroergotamine) should be administered with caution in patients receiving SPRYCEL. | <alfentanil, advise, SPRYCEL>, <astemizole, advise, SPRYCEL>, <terfenadine, advise, SPRYCEL>, <cisapride, advise, SPRYCEL>, <cyclosporine, advise, SPRYCEL>, <fentanyl, advise, SPRYCEL>, <pimozide, advise, SPRYCEL>, <quinidine, advise, SPRYCEL>, <sirolimus, advise, SPRYCEL>, <tacrolimus, advise, SPRYCEL>, <ergot alkaloids, advise, SPRYCEL>, <ergotamine, advise, SPRYCEL>, <dihydroergotamine, advise, SPRYCEL> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | After multiple dosing, interferon beta-1a (AVONEX 30 mcg IM once weekly) reduced TYSABRI clearance by approximately 30%. | <interferon beta-1a, mechanism, TYSABRI>, <AVONEX, mechanism, TYSABRI> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Coadministration of terfenadine with Itraconazole has led to elevated plasma concentrations of terfenadine, resulting in rare instances of life- threatening cardiac dysrhythmias and one death. | <terfenadine, mechanism, Itraconazole> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Another oral azole antifungal, ketoconazole, inhibits the metabolism of astemizole, resulting in elevated plasma concentrations of astemizole and its active metabolite desmethylastermizole which may prolong QT intervals. | <ketoconazole, mechanism, astemizole> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In vitro data suggest that itraconazole, when compared to ketoconazole, has a less pronounced effect on the biotransformation system responsible for the metabolism of astemizole. | <itraconazole, mechanism, astemizole> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Based on the chemical resemblance of itraconazole and ketoconazole, coadministration of astemizole with itraconazole is contraindicated. | <astemizole, advise, itraconazole> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Human pharmacokinetics data indicate that oral ketoconazole potently inhibits the metabolism of cisapride resulting in an eight-fold increase in the mean AUC of cisapride. | <ketoconazole, mechanism, cisapride> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Data suggest that coadministration of oral ketoconazole and cisapride can result in prolongation of the QT interval on the ECG. | <ketoconazole, effect, cisapride> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In vitro data suggest that itraconazole also markedly inhibits the biotransformation system mainly responsible for the metabolism of cisapride; | <itraconazole, mechanism, cisapride> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | therefore concomitant administration of Itraconazole with cisapride is contraindicated. | <Itraconazole, advise, cisapride> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Coadministration of Itraconazole with oral midazolam or triazolam has resulted in elevated plasma concentrations of the latter two drugs. | <Itraconazole, mechanism, midazolam>, <Itraconazole, mechanism, triazolam> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Coadministration of Itraconazole and cyclosporine, tacrolimus or digoxin has led to increased plasma concentrations of the latter three drugs. | <Itraconazole, mechanism, cyclosporine>, <Itraconazole, mechanism, tacrolimus>, <Itraconazole, mechanism, digoxin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Cyclosporine, tacrolimus and digoxin concentrations should be monitored at the initiation of Itraconazole therapy and frequently thereafter, and the dose of these three drug products adjusted appropriately. | <Cyclosporine, advise, Itraconazole>, <tacrolimus, advise, Itraconazole>, <digoxin, advise, Itraconazole> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Rhabdomyolysis has been observed in patients receiving HMG-CoA reductase inhibitors administered alone (at recommended dosages) or concomitantly with immunosuppressive drugs including cyclosporine. | <HMG-CoA reductase inhibitors, effect, immunosuppressive drugs>, <HMG-CoA reductase inhibitors, effect, cyclosporine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | When Itraconazole was coadministered with phenytoin, rifampin, or H2antagonists, reduced plasma concentrations of itraconazole were reported. | <Itraconazole, mechanism, phenytoin>, <Itraconazole, mechanism, rifampin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Although no studies have been conducted, concomitant administration of Itraconazole and phenytoin may alter the metabolism of phenytoin; | <Itraconazole, mechanism, phenytoin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | therefore, plasma concentrations of phenytoin should also be monitored when it is given concurrently with Itraconazole. | <phenytoin, advise, Itraconazole> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | It has been reported that Itraconazole enhances the anticoagulant effect of coumarin-like drugs. | <Itraconazole, effect, coumarin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Therefore, prothrombin time should be carefully monitored in patients receiving Itraconazole and coumarin-like drugs simultaneously. | <Itraconazole, advise, coumarin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Plasma concentrations of azole antifungal agents are reduced when given concurrently with isoniazid. | <azole antifungal agents, mechanism, isoniazid> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Itraconazole plasma concentrations should be monitored when Itraconazole and isoniazid are coadministered. | <Itraconazole, advise, isoniazid> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Severe hypoglycemia has been reported in patients concomitantly receiving azole antifungal agents and oral hypoglycemic agents. | <azole antifungal agents, effect, hypoglycemic agents> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Blood glucose concentrations should be carefully monitored when Itraconazole and oral hypoglycemic agents are coadministered. | <Itraconazole, advise, hypoglycemic agents> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Tinnitus and decreased hearing have been reported in patients concomitantly receiving Itraconazole and quinidine. | <Itraconazole, effect, quinidine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Edema has been reported in patients concomitantly receiving Itraconazole and dihydropyridine calcium channel blockers. | <Itraconazole, effect, dihydropyridine calcium channel blockers> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Tetracycline, a bacteriostatic antibiotic, may antagonize the bactercidal effect of penicillin and concurrent use of these drugs should be avoided. | <Tetracycline, effect, penicillin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Antibiotics: In vitro and/or in vivo data show that clarithromycin, erythromycin, and troleandomycin markedly inhibit the metabolism of cisapride, which can result in an increase in plasma cisapride levels and prolongation of the QT interval on the ECG. | <clarithromycin, mechanism, cisapride>, <erythromycin, mechanism, cisapride>, <troleandomycin, mechanism, cisapride> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Anticholinergics: Concurrent administration of certain anticholinergic compounds, such as belladonna alkaloids and dicyclomine, would be expected to compromise the beneficial effects of cisapride. | <anticholinergic compounds, effect, cisapride>, <belladonna alkaloids, effect, cisapride>, <dicyclomine, effect, cisapride> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | It is advisable to check coagulation time within the first few days after the start and discontinuation of cisapride therapy, with an appropriate adjustment of the anticoagulant dose, if necessary. | <cisapride, advise, anticoagulant> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Antidepressants: In vitro data indicate that nefazodone inhibits the metabolism of cisapride, which can result in an increase in plasma cisapride levels and prolongation of the QT interval on the ECG. | <nefazodone, mechanism, cisapride> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Antifungals: In vitro and/or in vivo data indicate that fluconazole, itraconazole, and oral ketoconazole markedly inhibit the metabolism of cisapride, which can result in an increase in plasma cisapride levels and prolongation of the QT interval on the ECG. | <fluconazole, mechanism, cisapride>, <itraconazole, mechanism, cisapride>, <ketoconazole, mechanism, cisapride> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Human pharmacokinetic data indicate that oral ketoconazole markedly inhibits the metabolism of cisapride, resulting in a mean eight-fold increase in AUC of cisapride. | <ketoconazole, mechanism, cisapride> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | A study in 14 normal male and female volunteers suggests that coadministration of cisapride and ketoconazole can result in prolongation of the QT interval on the ECG. | <cisapride, effect, ketoconazole> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | H2 Receptor Antagonists: Cimetidine coadministration leads to an increased peak plasma concentration and AUC of cisapride, there is no effect on cisapride absorption when it is coadministered with ranitidine. | <Cimetidine, mechanism, cisapride> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The gastrointestinal absorption of cimetidine and ranitidine is accelerated when they are coadministered with cisapride. | <cimetidine, mechanism, cisapride>, <ranitidine, mechanism, cisapride> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Protease Inhibitors: In vitro data indicate that indinavir and ritonavir markedly inhibit the metabolism of cisapride which can result in an increase in plasma cisapride levels and prolongation of the QT interval on the ECG. | <indinavir, mechanism, cisapride>, <ritonavir, mechanism, cisapride> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Cisapride should not be used concomitantly with other drugs known to prolong the QT interval: certain antiarrhythmics, including those of Class IA (such as quinidine and procainamide) and Class III (such as sotalol); | <Cisapride, advise, antiarrhythmics>, <Cisapride, advise, quinidine>, <Cisapride, advise, procainamide>, <Cisapride, advise, sotalol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Chlorotrianisene may interact with antidepressants, aspirin, barbiturates, bromocriptine, calcium supplements, corticosteroids, corticotropin, cyclosporine, dantrolene, nicotine, somatropin, tamoxifen, and warfarin. | <Chlorotrianisene, int, antidepressants>, <Chlorotrianisene, int, aspirin>, <Chlorotrianisene, int, barbiturates>, <Chlorotrianisene, int, bromocriptine>, <Chlorotrianisene, int, calcium>, <Chlorotrianisene, int, corticosteroids>, <Chlorotrianisene, int, corticotropin>, <Chlorotrianisene, int, cyclosporine>, <Chlorotrianisene, int, dantrolene>, <Chlorotrianisene, int, nicotine>, <Chlorotrianisene, int, somatropin>, <Chlorotrianisene, int, tamoxifen>, <Chlorotrianisene, int, warfarin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In combination with other central nervous system depressants, heroin may still kill even experienced users, particularly if their tolerance to the drug has reduced or the strength of their usual dose has increased. | <central nervous system depressants, effect, heroin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Toxicology studies of heroin-related deaths reveal frequent involvement of other central nervous system depressants, including alcohol, benzodiazepines such as diazepam (Valium), and, to a rising degree, methadone. | <heroin, effect, central nervous system depressants>, <heroin, effect, alcohol>, <heroin, effect, benzodiazepines>, <heroin, effect, diazepam>, <heroin, effect, Valium>, <heroin, effect, methadone> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Cocaine sometimes proves to be fatal when used in combination with heroin. | <Cocaine, effect, heroin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | - Cholestyramine and colestipol resins: Cholestytamine and colestipol resins have the potential of binding thiazide diuretics and reducing diuretic absorption from the gastrointestinal tract | <Cholestytamine, mechanism, thiazide diuretics>, <colestipol, mechanism, thiazide diuretics> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | - Lithium: Generally should not be given with diuretics. | <Lithium, advise, diuretics> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity. | <Diuretic agents, mechanism, lithium>, <Diuretic agents, mechanism, lithium> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Refer to the package insert for lithium preparations before use of such preparations with chlorothiazide | <lithium, advise, chlorothiazide> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | - Non-steroidal Anti-inflammatory Drugs: In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. | <non-steroidal anti-inflammatory agent, effect, loop diuretics>, <non-steroidal anti-inflammatory agent, effect, potassium-sparing diuretics>, <non-steroidal anti-inflammatory agent, effect, thiazide diuretics> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Therefore, when chlorothiazide and non-steroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained | <chlorothiazide, advise, non-steroidal anti-inflammatory agents> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Renal clearance measurements of PAH cannot be made with any significant accuracy in patients receiving sulfonamides, procaine, or thiazolesulfone. | <PAH, effect, sulfonamides>, <PAH, effect, procaine>, <PAH, effect, thiazolesulfone> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Probenecid depresses tubular secretion of certain weak acids such as PAH. | <Probenecid, mechanism, PAH> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Therefore, patients receiving probenecid will have erroneously low ERPF and Tm PAH values. | <probenecid, effect, PAH> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Patients on oral antidiabetic agents receiving VELCADE treatment may require close monitoring of their blood glucose levels and adjustment of the dose of their antidiabetic medication. | <antidiabetic agents, advise, VELCADE> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Antihistamines may enhance the effects of tricyclic antidepressants, barbiturates, alcohol, and other CNS depressants. | <Antihistamines, effect, tricyclic antidepressants>, <Antihistamines, effect, barbiturates>, <Antihistamines, effect, alcohol>, <Antihistamines, effect, CNS depressants> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | MAO inhibitors prolong and intensify the anticholinergic effects of antihistamines. | <MAO inhibitors, effect, antihistamines> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Sympathomimetic amines may reduce the antihypertensive effects of reserpine, veratrum alkaloids, methyldopa and mecamylamine. | <Sympathomimetic amines, effect, reserpine>, <Sympathomimetic amines, effect, veratrum alkaloids>, <Sympathomimetic amines, effect, methyldopa>, <Sympathomimetic amines, effect, mecamylamine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Effects of sympathomimetics are increased with MAO inhibitors and beta adrenergic blockers. | <sympathomimetics, effect, MAO inhibitors>, <sympathomimetics, effect, beta adrenergic blockers> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Because of the danger of a potentially fatal prolongation of the QTc interval, halofantrine must not be given simultaneously with or subsequent to Mefloquine. | <halofantrine, advise, Mefloquine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Concomitant administration of Mefloquine and other related compounds (eg, quinine, quinidine and chloroquine) may produce electrocardiographic abnormalities and increase the risk of convulsions. | <Mefloquine, effect, quinine>, <Mefloquine, effect, quinidine>, <Mefloquine, effect, chloroquine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | This appears to be the only clinically relevant interaction of this kind with Mefloquine, although theoretically, coadministration of other drugs known to alter cardiac conduction (eg, anti-arrhythmic or beta-adrenergic blocking agents, calcium channel blockers, antihistamines or H1-blocking agents, tricyclic antidepressants and phenothiazines) might also contribute to a prolongation of the QTc interval. | <Mefloquine, effect, anti-arrhythmic>, <Mefloquine, effect, beta-adrenergic blocking agents>, <Mefloquine, effect, calcium channel blockers>, <Mefloquine, effect, antihistamines>, <Mefloquine, effect, H1-blocking agents>, <Mefloquine, effect, tricyclic antidepressants>, <Mefloquine, effect, phenothiazines> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In patients taking an anticonvulsant (eg, valproic acid, carbamazepine, phenobarbital or phenytoin), the concomitant use of Mefloquine may reduce seizure control by lowering the plasma levels of the anticonvulsant. | <anticonvulsant, effect, Mefloquine>, <valproic acid, effect, Mefloquine>, <carbamazepine, effect, Mefloquine>, <phenobarbital, effect, Mefloquine>, <phenytoin, effect, Mefloquine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | When Mefloquine is taken concurrently with oral live typhoid vaccines, attenuation of immunization cannot be excluded. | <Mefloquine, effect, live typhoid vaccines> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Nevertheless, the effects of Mefloquine on travelers receiving comedication, particularly diabetics or patients using anticoagulants, should be checked before departure. | <Mefloquine, advise, anticoagulants> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Lithium generally should not be given with diuretics because they reduce its renal clearance and add a high risk of lithium toxicity. | <Lithium, mechanism, diuretics> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | EDECRIN may increase the ototoxic potential of other drugs such as aminoglycoside and some cephalosporin antibiotics. | <EDECRIN, effect, aminoglycoside>, <EDECRIN, effect, cephalosporin antibiotics> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | A number of drugs, including ethacrynic acid, have been shown to displace warfarin from plasma protein; | <ethacrynic acid, mechanism, warfarin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In some patients, the administration of a non- steroidal antiinflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium- sparing and thiazide diuretics. | <non- steroidal antiinflammatory agent, effect, loop diuretics>, <non- steroidal antiinflammatory agent, effect, potassium- sparing diuretics>, <non- steroidal antiinflammatory agent, effect, thiazide diuretics> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Therefore, when EDECRIN and non- steroidal anti- inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained. | <EDECRIN, effect, non- steroidal anti- inflammatory agents> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Non-selective MAO inhibitors including tranylcypromine sulfate, phenelzine sulfate, and pargyline HC1: Concomitant use of L-tyrosine and non-selective MAO inhibitors may cause hypertension. | <L-tyrosine, effect, MAO inhibitors> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Based on adult data, lower doses of caffeine may be needed following coadministration of drugs which are reported to decrease caffeine elimination (e.g., cimetidine and ketoconazole) and higher caffeine doses may be needed following coadministration of drugs that increase caffeine elimination (e.g., phenobarbital and phenytoin). | <caffeine, advise, cimetidine>, <caffeine, advise, ketoconazole>, <caffeine, advise, phenobarbital>, <caffeine, advise, phenytoin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Caffeine administered concurrently with ketoprofen reduced the urine volume in 4 healthy volunteers. | <Caffeine, effect, ketoprofen> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Auranofin should be avoided by patients with a history of serious reaction to any gold medication, including Solganal and Myochrysine. | <Auranofin, advise, gold medication>, <Auranofin, advise, Solganal>, <Auranofin, advise, Myochrysine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Auranofin should not be used together with penicillamine (Depen, Cuprimine), another arthritis medication. | <Auranofin, advise, penicillamine>, <Auranofin, advise, Depen>, <Auranofin, advise, Cuprimine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The in vitro interaction between nevirapine and the antithrombotic agent warfarin is complex. | <nevirapine, int, warfarin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | When warfarin is co-administered with nevirapine, anticoagulation levels should be monitored frequently. | <warfarin, advise, nevirapine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Clarithromycin exposure was significantly decreased by nevirapine; | <Clarithromycin, mechanism, nevirapine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Oral contraceptives and other hormonalmethods of birth control should not be usedas the sole method of contraception inwomen taking nevirapine, since nevirapinemay lower the plasma levels of thesemedications. | <contraceptives, advise, nevirapine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Nevirapine and ketoconazole should not beadministered concomitantly becausedecreases in ketoconazole plasmaconcentrations may reduce the efficacy of the drug. | <Nevirapine, advise, ketoconazole> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | A dose increase of lopinavir/ritonavir to 533/133 mg twice daily with food isrecommended in combination with nevirapine. | <lopinavir, advise, nevirapine>, <ritonavir, advise, nevirapine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Methadone levels may be decreased; increased dosages may be required to prevent symptoms of opiate withdrawal. Methadone maintained patients beginning nevirapine therapy should be monitored forevidence of withdrawal and methadone dose should be adjusted accordingly. | <Methadone, advise, nevirapine> |
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