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stringlengths 6
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Q20719 | MSLASNVLLQASRLGEMVIKRGGATGLMVHRDTKENNLNVKFKFTSENQERIKAIMDIYPEGHKAGALIPLLDLAQRQHGWLPISAMHEVAKILEVPRMRAYEVATFYTMFNRQPVGKYFLQVCATTPCMLRGAETITETIEKKLGIHAGETTKDGLFTLAEVECLGACVNAPMIQINDDYFEDLTPKDVNEILDDLKAGRKPAAGPRSGRLAAEPFGELTSLKETPPGPGFGLQAALK | Cofactor: Binds 1 [2Fe-2S] cluster.
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Catalytic Activity: a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)
Sequence Mass (Da): 26241
Sequence Length: 239
Subcellular Location: Mitochondrion inner membrane
EC: 7.1.1.2
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Q54F10 | MFRSLLKRTTFLNQLNKSNGFNRNYFKQSTLTRSDALSRHVETEDNNEHTPFDFTQENLVKVEKILAKYPKQYRQSALIPLLDLAQRQNGGWISLRAMDKVAHICGIAPMTAYEVASFYTMFNRTKIGENFVQVCTTTPCMLRGSGEIIKTCKSHLGIQVGETTPDNKFTLVEVECLGACVNAPMMCINDDFYEDLTSASTINLLDQIKNNKPTKIGPQTHRKAAEGPQGKTTLLEPPVGPTCRDDL | Cofactor: Binds 1 [2Fe-2S] cluster.
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Catalytic Activity: a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)
Sequence Mass (Da): 27742
Sequence Length: 247
Subcellular Location: Mitochondrion inner membrane
EC: 7.1.1.2
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P19404 | MFFSAALRARAAGLTAHWGRHVRNLHKTVMQNGAGGALFVHRDTPENNPDTPFDFTPENYKRIEAIVKNYPEGHKAAAVLPVLDLAQRQNGWLPISAMNKVAEVLQVPPMRVYEVATFYTMYNRKPVGKYHIQVCTTTPCMLRNSDSILEAIQKKLGIKVGETTPDKLFTLIEVECLGACVNAPMVQINDNYYEDLTAKDIEEIIDELKAGKIPKPGPRSGRFSCEPAGGLTSLTEPPKGPGFGVQAGL | Cofactor: Binds 1 [2Fe-2S] cluster.
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
Catalytic Activity: a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 27392
Sequence Length: 249
Subcellular Location: Mitochondrion inner membrane
EC: 7.1.1.2
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Q79671 | MGNAWSKSKFAGWSEVRDRMRRSSSDPQQPCAPGVGAVSRELATRGGISSSHTPQNNAALAFLDSHKDEDVGFPVRPQVPLRPMTFKAAFDLSFFLKEKGGLDGLIYSHKRAEILDLWIYHTQGFFPDWQCYTPGPGPRFPLTFGWLFKLVPVSAEEAERLGNTNEDASLLHPACNHGAEDAHGEILKWQFDRSLGLTHIALQKHPELFPK | Function: Factor of infectivity and pathogenicity, required for optimal virus replication. Alters numerous pathways of T-lymphocyte function and down-regulates immunity surface molecules in order to evade host defense and increase viral infectivity. Alters the functionality of other immunity cells, like dendritic cells, monocytes/macrophages and NK cells.
PTM: The virion-associated Nef proteins are cleaved by the viral protease to release the soluble C-terminal core protein. Nef is probably cleaved concomitantly with viral structural proteins on maturation of virus particles.
Location Topology: Lipid-anchor
Sequence Mass (Da): 23555
Sequence Length: 211
Domain: The N-terminal domain is composed of the N-myristoyl glycine and of a cluster of positively charged amino acids. It is required for inner plasma membrane targeting of Nef and virion incorporation, and thereby for infectivity. This domain is also involved in binding to TP53.
Subcellular Location: Host cell membrane
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E7FE40 | MAGFMKYKSVSTTIETVRLKLILTAVLFLFPFSQTSGASRPIIEIKDGQEIKVQAAQHFCYNNTIIPGWRETWTRIQVRVWSTTKLKVTVVNDEQDLKELEHFSIWKLVQYFVREQTNETTISVSLFNNKTCFRVDPSESRTLYTVQPSRHFDIYLFLVFLAGVLLFFYADVLSRSQVFHYSAGMSTGMIASLLILIFIVYRFLPKKSPFYMLVVGGWSFSLYIIQLVFRNLQVILTDHWHLAIGYVFVVGFISFAVCYRYGPLVEERSINILSWALQIFGLLLVYAGIQVQQVAFAIMIAAFCSKNLEYPFNTAFMLYHKLKPKKLEPRRLLTEEEFQRQSEVETQKALEELRKYCGSPDFNTWKTVSRLQSPKRFADFIEGSPHLLSNEVSVHMQEYGLGGSFFEDELFSTDEEDKEEEEDGWETEDDIKPEVTSPRMNNTRGK | Function: Contributes to nuclear envelope stiffness in germ cells (By similarity). Involved in male and female fertility .
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 51780
Sequence Length: 446
Subcellular Location: Nucleus inner membrane
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O14524 | MAGGMKVAVSPAVGPGPWGSGVGGGGTVRLLLILSGCLVYGTAETDVNVVMLQESQVCEKRASQQFCYTNVLIPKWHDIWTRIQIRVNSSRLVRVTQVENEEKLKELEQFSIWNFFSSFLKEKLNDTYVNVGLYSTKTCLKVEIIEKDTKYSVIVIRRFDPKLFLVFLLGLMLFFCGDLLSRSQIFYYSTGMTVGIVASLLIIIFILSKFMPKKSPIYVILVGGWSFSLYLIQLVFKNLQEIWRCYWQYLLSYVLTVGFMSFAVCYKYGPLENERSINLLTWTLQLMGLCFMYSGIQIPHIALAIIIIALCTKNLEHPIQWLYITCRKVCKGAEKPVPPRLLTEEEYRIQGEVETRKALEELREFCNSPDCSAWKTVSRIQSPKRFADFVEGSSHLTPNEVSVHEQEYGLGSIIAQDEIYEEASSEEEDSYSRCPAITQNNFLT | Function: Together with EMD, contributes to nuclear envelope stiffness in germ cells . Required for female fertility (By similarity).
PTM: Phosphorylation may regulate its interaction with RAN-GTP.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 50640
Sequence Length: 444
Domain: The transmembrane domains are required and sufficient for its oligomerization.
Subcellular Location: Nucleus inner membrane
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Q6ZQE4 | MAGGIKVSVWSAVGPGPRCWGAGGGGGATWLLLVVAGCVVCGSADVNVVMLQESQVDMNSSQQFCYKNVLIPKWHDIWTRIQVRVNSSKLVRVTQVDNEEKLKELEQFSIWNFFSSFLKEKLNDTYVNVGLYSTKTCLKVEMIEKDTTYSVTVTRRFDPKLFLVFLLGLTLFFCGDLLSRSQIFYYSTGMSVGIVASLLIVIFMISKFMPKRSPIYVILVGGWSFSLYLIQLVFKNLQEIWRSYWHYLLSYILTVGFMSFAVCYKYGPLENERSINLLTWTLQLLGLGLMYSSIQIPHVAFALIVIALCTKNLEYPIHWLCSTYRRMCKASGKPVPPRLLTEEEYRIQGEVETQKALQELREFCNSPECSAWKTISRIQSPKRFADFVEGSFHLTPNEVSVHEQEYGLGSIFTQDEELSSEEEGSEYPTFTQNNFLT | Function: Together with EMD, contributes to nuclear envelope stiffness in germ cells . Required for female fertility .
PTM: Phosphorylated. Phosphorylation may regulate its interaction with RAN-GTP.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 49817
Sequence Length: 437
Domain: The transmembrane domains are required and sufficient for its oligomerization.
Subcellular Location: Nucleus inner membrane
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F1QYC4 | MEKLAAFILVLTLLCAYWQSAEGIREYSYADCTDVKGDSAHRYSGSRCFCYSPGTVIKWKDIWSTFKVNVSSNVDVVVVFPMETINCHHPDDLLTVMNCFVEHYWPSTVQRETSLEIPLVDVDICFMIKSPRSNTEYTLHVSNKRLNRMCFLLFVCGLILFFGARNICRSSLFFYTTGVSLGIIATFVFLTLLLRNFVPKRGLFLVLLGAGSGLSYMGIQRVLNEWDDIVTEHWMELLAYVLISGLFSFAVCYKHGPITNKHTLNFMTCSMQAVGIVLLYYGITFPPAYFVLVAVLLCWKILPLAWSLLMGICSLFYSFLALFRRRRRPTVRLLTEEEYREQGEIHTRASLDELREYCNRPGFPAWETVLRLRSPQRFAEFLRQGSHITQEEHQNHENHYGLGGAYYENVIFNNSSSSDTQSHREEAEDNSEDEIVGNSPPVLNNLPSPTIYPPTICPYPPVTYTPQPEPLDPEDQDFF | Function: Contributes to nuclear envelope stiffness in germ cells (By similarity). Involved in male and female fertility .
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 54933
Sequence Length: 479
Subcellular Location: Nucleus inner membrane
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Q19293 | MRLLTLALLVAGSLAYKFEDCEQKPAALNQVLRVGAKLYSYNLDFFYQKALPYNAIYAFTDVFLQTNLTNADQYQFYQGTNCTTVQQLYDNDNRYFGILRKAALLRSHQLNPFNDTIVGVSTTEPYEISVLIWKVNYFRVGVYVGAIVLFLLASKLVRNVVFYYTSGCSFGLLASLLLVAFIVWRVAPKKTIGVPILIGGWSVSLYMLHFAWSNLQSIMIEYQKYVIGYFATVLLISMAVCYKRGPPTDARSHDIAQWTLQLVALALIYFSVQMVEVSTGTIGALIIQQICRGFLFAGIRWYFVGLKAVWRKFFPARRRLLNEEEYEEQAEKTTKEQLAQLREYCKKEGNRPWKIAGNVRSARRLARFIEGEDDHITEDEIYAHELTGDVLDDEDYDFNEDYGLRTPNESHFDLEDDEDGAEEWDEVVVRRRASEYGRDSVQSVRVPRSVSSRLLSPYQGQNHMNRSLGPGIGFRRDSTPRHGNFQSEHRPRMPRTEQIYRSRRVEYDVKNGRVEGPSSSTASGMTPSEYMRKARRIDATSKTPTRKSRHPTESEDADE | Function: Contributes to nuclear envelope stiffness in germ cells (By similarity). Required for fertility .
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 64240
Sequence Length: 559
Subcellular Location: Nucleus inner membrane
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Q9VXD6 | MHSAGLLMLTVAGYFTSGIPGNTASSDVAYLTPGTYINLSENILGLQTLRTFCYPGKRLTVSSLFETVEFVLAIGSDDYSQYGGKTPEEVLQHYKDKQSLFSITLFAQKRQLLQLSPFEQQCIGISSRQAYTVILNSIPLDLWRLAQFAVGILILFSARRLAKNSVFYYLVGIVIGICASLLVVIYLAAKLFPRRTMMYGVLIGGWTIGFYVIKQLADNLRLILITYRDHVLGYLVITGLISFLICYRIGPPKNPRSQTIVMWVLQAIGAVMAYFSSWHTSAVIFIMVLVFVAHYFPISWTNQIKFMYRRRFPLKRRMLTQEEYEQQTAVETSKSLADLRKYVNSPECKQWAVMGKLRDPLRFASFANGAPHLDDEEIEDHSRTIEESMDAAPEEESVEEPEEDKPAELLPLPNSQFRYQQAARNSEPEPESESDDSEEEEFFEQEVDLRQVVQ | Function: Contributes to nuclear envelope stiffness in germ cells . Required for male and female fertility .
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 51685
Sequence Length: 454
Subcellular Location: Nucleus inner membrane
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Q92979 | MAAPSDGFKPRERSGGEQAQDWDALPPKRPRLGAGNKIGGRRLIVVLEGASLETVKVGKTYELLNCDKHKSILLKNGRDPGEARPDITHQSLLMLMDSPLNRAGLLQVYIHTQKNVLIEVNPQTRIPRTFDRFCGLMVQLLHKLSVRAADGPQKLLKVIKNPVSDHFPVGCMKVGTSFSIPVVSDVRELVPSSDPIVFVVGAFAHGKVSVEYTEKMVSISNYPLSAALTCAKLTTAFEEVWGVI | Function: S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position . Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome .
Catalytic Activity: pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine
Sequence Mass (Da): 26720
Sequence Length: 244
Subcellular Location: Nucleus
EC: 2.1.1.-
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Q57977 | MTYNIILAKSALELIPEEIKNKIRKSRVYKYDILDSNYHYKAMEKLKDKEMRGRPDIIHISLLNILDSPINHEKKLNIYIHTYDDKVLKINPETRLPRNYFRFLGVMEKVLKGERNHLIKMEEKTLEDLLNEINAKKIAIMTKTGKLTHPKLLKEYDTFIIGGFPYGKLKINKEKVFGDIKEISIYNKGLMAWTVCGIICYSLSF | Function: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of pseudouridine at position 914 (Psi914) in 16S rRNA. Is not able to methylate uridine at this position.
Catalytic Activity: pseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine
Sequence Mass (Da): 24082
Sequence Length: 205
EC: 2.1.1.-
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A0B5L3 | MISMLLADSELELVPREIVGYPAVRLNARKRNKSPAKSILDASLHHSAMRALPMGDRRGRPDIVHVFLLVALESVLNRVGQLRVYIHTRNNEMITIDPTTRIPKNYPRFVGLMESLFEKGSVPEREPLIVMQRDRDIGACIGEIPHEKVILLSPKGRRVRLSDYVKECDNALFILGGFPKGEFISDVLSEADDTISIYEESLSVWTVASEILVNYENHVLEASAPS | Function: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
Catalytic Activity: a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine
Sequence Mass (Da): 25401
Sequence Length: 226
EC: 2.1.1.-
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P69476 | IGPSGVETTVYAGDGEYLMXLSIGTPAQPFSAIMDTGSDLIWTQXQPXTQXFXQSDPQGSSSFSTLPCGYGDSETQGSMGTETFTFGSVSIPNITFGXGEGPLPLPXQLDVAKYITLDLPIDPSAFDLCFQTPSDPSNLQIPTFVMHFDTGNSVVSFVSAQCGA | Function: Extracellular proteinase found in the pitcher fluid of carnivorous plants. Digest prey for nitrogen uptake.
Catalytic Activity: Similar to pepsin, but also cleaves on either side of Asp and at Lys-|-Arg.
Sequence Mass (Da): 17271
Sequence Length: 164
Subcellular Location: Secreted
EC: 3.4.23.12
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Q766C3 | MASSLYSFLLALSIVYIFVAPTHSTSRTALNHRHEAKVTGFQIMLEHVDSGKNLTKFQLLERAIERGSRRLQRLEAMLNGPSGVETSVYAGDGEYLMNLSIGTPAQPFSAIMDTGSDLIWTQCQPCTQCFNQSTPIFNPQGSSSFSTLPCSSQLCQALSSPTCSNNFCQYTYGYGDGSETQGSMGTETLTFGSVSIPNITFGCGENNQGFGQGNGAGLVGMGRGPLSLPSQLDVTKFSYCMTPIGSSTPSNLLLGSLANSVTAGSPNTTLIQSSQIPTFYYITLNGLSVGSTRLPIDPSAFALNSNNGTGGIIIDSGTTLTYFVNNAYQSVRQEFISQINLPVVNGSSSGFDLCFQTPSDPSNLQIPTFVMHFDGGDLELPSENYFISPSNGLICLAMGSSSQGMSIFGNIQQQNMLVVYDTGNSVVSFASAQCGAS | Function: Extracellular proteinase found in the pitcher fluid of carnivorous plants. Digest prey for nitrogen uptake.
Catalytic Activity: Similar to pepsin, but also cleaves on either side of Asp and at Lys-|-Arg.
Sequence Mass (Da): 46357
Sequence Length: 437
Subcellular Location: Secreted
EC: 3.4.23.12
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Q8U1E6 | MKKRLHLIIADSELELVPESIIDHPAIVNYAKRRKKKPEKIILDSTYHHAALRQLEDGERRGRPDIVHICLLNALDSILNKEDRLRVYVHTRNDEVIYVDPSTRLPRNYNRFIGLMESLFEKKVVPEDLQLLRLEKKTLAELINEISPDAVFIMHENGEFMIPKHFGKLLASFKKPVVIVGGFPHGDFRSKVEGVKISLYREPLMAWTIVNEVIVSYEWEVIK | Function: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
Catalytic Activity: a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine
Sequence Mass (Da): 25955
Sequence Length: 223
EC: 2.1.1.-
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A1RVH0 | MIVVLAESALELVPRELWNHPVIQADAKRRGKKPGEILLDRARHHLAMSSLRDASKRGRPDIVHQVLLVFQYSLLNKRGLGRIYIHTQGDYTIYVRWETRIPKNYNNFVSLMEQLYATGRVPPKGEPLIELYKKDLSTLLRELGGRWVVLHESGVKKPFIELGAALLNSVVVIGGFPHGDFTNKWVLEKADAIYKIGDETMDAAQVVYRAITAAEVAAGLL | Function: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
Catalytic Activity: a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine
Sequence Mass (Da): 24891
Sequence Length: 221
EC: 2.1.1.-
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Q97WJ0 | MHLNIILLEASLELVPKEIVNHPAVIKNAKRRNKKPEDTLLDISLHYHAMKYLENSHKRGRPDILHQALLVILTDPVIKGDIFIHTIQSKIIKVNPNMRPPKNYLRFIGLMEQLLKYGKIPINGDETLMEVTNLTLDNIVNRYDLILLSEKGEKINPEEICKLDEKWLLGIGAFPHGDFSDKILNLAKKIYSISGFPLETQQVLCRIFSACNSILGWP | Function: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
Catalytic Activity: a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine
Sequence Mass (Da): 24933
Sequence Length: 218
EC: 2.1.1.-
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Q10107 | MPTYSKRKSRGSLEVSEKTNQPKFIKRSQSSETITSGETASELMQDEKEQSNGAVGSIEDEELQRLRENQASVEALSKKPESIDRELGVEALEIDNVVKSDEEKEDPNGASSKTVKARPLPAGSVHRVTTHMAPIPARSIGSHDTTTQRLIVVLDQACLEIYKVGKAKDAKYQLLNCDDHQGILKKLNRNIAQARPDITHQCLLTLLDSPLNKAGRLQVYIHTAKKVLIEVNPSVRIPRTFKRFSGLMVQLLHKLSIRSVNGNEKLLKVIKNPVTDYLPPNCRKATLSFDAPTVPPRKYLETLQPNQSVCIAIGAMAHGPDDFSDGWVDEKISISDYPLSASIACSKFLHSMEDFLGIV | Function: S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates the pseudouridine corresponding to position 1189 (Psi1189) in S.cerevisiae 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes (By similarity). Essential for cell growth. It also has a key role in promoting the mating function .
Catalytic Activity: a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine
Sequence Mass (Da): 39775
Sequence Length: 359
Subcellular Location: Nucleus
EC: 2.1.1.-
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A3DNG9 | MNMKEPISIILLESALELVPKELWKHPAVVKNARRRGKKPGETLLDVSLHYHAMKKLKDKEKRGRPDIVHISLLNALESPLNKEGYLRIYIHTYPGHIIFVKPETRIPRNYNRFVGLMEQLLIHGKVPPDSDDPLLYVKTMTISDLLEKINKNGIILLREHGEKEKPENIVKYAVENNYAIGIGGFPHGDYSQEIISISKAEFSIYNKPLTTWITISRVIVGAEHLYNII | Function: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
Catalytic Activity: a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine
Sequence Mass (Da): 26375
Sequence Length: 230
EC: 2.1.1.-
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Q9HJ48 | MLHLVIADAELETIPEEMQADPAIRRFAKKRNKRVDRMILDSNYMHTSIDRYFPNESKRRGRPDIIYLLLEMTQESILNHKNQLRTYVHTRNNQVIRISPITRMPKSYNRFIGLFEDLFEKRIITNNGKELLSMEESSLGDLINSIRRDRTILLHPKGEMRKPSEFISNANILIVIGGFSEGDFISDTSFINERYAIFDQELTIWSVANEMVANYERAVGLT | Function: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
Catalytic Activity: a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine
Sequence Mass (Da): 25939
Sequence Length: 222
EC: 2.1.1.-
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Q5JI44 | MLHLIIAEAELELVPESIRDHPAVVNYARRRKKRPEEAILDSTYHHAALKKLPDGDRRGRPDIVHICLLNALESIANKEGFLRVYVHTRNDEVIHIKPETRLPRNYNRFLGLMESLFKKGAVPEGLELLRIEKKPLESLIEDINPDTVFIMHEEGELIRPRSFGEILASHQNPVVVVGGFPHGDFMRPIEGTKVSLYREPLMAWTVVSEVIVNFEAALGL | Function: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
Catalytic Activity: a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine
Sequence Mass (Da): 25073
Sequence Length: 220
EC: 2.1.1.-
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A8MQ27 | MGNTVHRTLPDPSPPARLLATRPCCGPGPERRPVLGEAPRFHAQAKGKNVRLDGHSRRATRRNSFCNGVTFTQRPIRLYEQVRLRLVAVRPGWSGALRFGFTAHDPSLMSAQDIPKYACPDLVTRPGYWAKALPENLALRDTVLAYWADRHGRVFYSVNDGEPVLFHCGVAVGGPLWALIDVYGITDEVQLLESAFADTLTPARLSQARFSACLPPSSHDAANFDNNELENNQVVAKLGHLALGRAPGPPPADAAAAAIPCGPRERPRPASSPALLEADLRFHATRGPDVSLSADRKVACAPRPDGGRTLVFSERPLRPGESLFVEVGRPGLAAPGALAFGITSCDPGVLRPNELPADPDALLDRKEYWVVARAGPVPSGGDALSFTLRPGGDVLLGINGRPRGRLLCVDTTQALWAFFAVRGGVAGQLRLLGTLQSSPATTTPSGSLSGSQDDSDSDMTFSVNQSSSASESSLVTAPSSPLSPPVSPVFSPPEPAGIKNGECTVCFDGEVDTVIYTCGHMCLCHSCGLRLKRQARACCPICRRPIKDVIKIYRP | Function: E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands.
Catalytic Activity: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
Sequence Mass (Da): 59270
Sequence Length: 555
Pathway: Protein modification; protein ubiquitination.
Subcellular Location: Cytoplasm
EC: 2.3.2.27
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Q0MW30 | MGNTVHRTLPDSSPPARLLATRPCYGPGPERRAVLGEAPRFHAQAKGKNVRLDGHSRRATRRNSFCNGVTFTQRPIRLYEQVRLRLVAVRPGWSGALRFGFTAHDPSLMSAQDIPKYACPDLVTRPGYWAKALPENLALRDTVLAYWADRHGRVFYSVNDGEPVLFHCGVAVGGPLWALIDVYGITDEVQLLESTFADTLTPLRLGQARLSACPPPGSHDAANFDNNELENNQVVAKLGHLALGRPDAAVPCVARERPRPASSPALLDAELRFHATRGPDVSLSADRRLACAPRPDGGRTLVFSERPLRPGESLCVEVGRPGLAAPAAVAFGITSCDPGALRPSELPADPAALLDRKEYWVVARAGPVPSGGDALSFTLRPGGDVLLAVNGRPRGRLLCVDTSQALWAFFAVRGGVAGQLRLLGTLQSSSETMTPSGSFSGSQDDSDSDMTFGVNQSSSASESSLVTAPSSPLSPPVSPAFSAPEPTGSRNGECTVCFDSEVDTVIYTCGHMCLCHGCGLRLRRQARACCPICRRPIKDVIKIYRP | Function: E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands.
Catalytic Activity: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
Sequence Mass (Da): 58527
Sequence Length: 546
Pathway: Protein modification; protein ubiquitination.
Subcellular Location: Cytoplasm
EC: 2.3.2.27
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Q07663 | MFGTSVSALCLLFLLSVCTACYISNCPIGGKRSALAFPSRKCMSCGPGDRGRCFGPNICCGEGMGCYVGSPEAAGCVEENYLPSPCEVGGRVCGSEEGRCAAPGICCDVEGCSIDQSCTEEDEAEYISQSVSSSHGHDLLMKLLNMISHTPPHRVHK | Function: Isotocin causes contraction of smooth muscles.
PTM: Seven disulfide bonds are present in neurophysin.
Sequence Mass (Da): 16497
Sequence Length: 157
Subcellular Location: Secreted
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P32560 | QLYENKSRRPYIL | Function: Smooth muscle-contracting peptide.
PTM: Neurotensin is cleaved and degraded by Angiotensin-converting enzyme (ACE) and neprilysin (MME).
Sequence Mass (Da): 1680
Sequence Length: 13
Subcellular Location: Secreted
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P30990 | MMAGMKIQLVCMLLLAFSSWSLCSDSEEEMKALEADFLTNMHTSKISKAHVPSWKMTLLNVCSLVNNLNSPAEETGEVHEEELVARRKLPTALDGFSLEAMLTIYQLHKICHSRAFQHWELIQEDILDTGNDKNGKEEVIKRKIPYILKRQLYENKPRRPYILKRDSYYY | Function: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
PTM: Neurotensin is cleaved and degraded by Angiotensin-converting enzyme (ACE) and neprilysin (MME).
Sequence Mass (Da): 19795
Sequence Length: 170
Subcellular Location: Secreted
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Q9D3P9 | MRGMNLQLVCLTLLAFSSWSLCSDSEEDVRALEADLLTNMHTSKISKASPPSWKMTLLNVCSLINNVNSPAEEAGDMHDDDLVGKRKLPLVLDGFSLEAMLTIFQLQKICRSRAFQHWEIIQEDILDNVNDKNEKEEVIKRKIPYILKRQLYENKPRRPYILKRGSYYY | Function: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle (By similarity).
PTM: Neurotensin is cleaved and degraded by Angiotensin-converting enzyme (ACE) and neprilysin (MME).
Sequence Mass (Da): 19608
Sequence Length: 169
Subcellular Location: Secreted
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P20068 | MIGMNLQLVCLTLLAFSSWSLCSDSEEDVRALEADLLTNMHASKVSKGSPPSWKMTLLNVCSLINNLNSAAEEAGEMRDDDLVAKRKLPLVLDDFSLEALLTVFQLQKICRSRAFQHWEIIQEDILDHGNEKTEKEEVIKRKIPYILKRQLYENKPRRPYILKRASYYY | Function: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
PTM: Neurotensin is cleaved and degraded by Angiotensin-converting enzyme (ACE) and neprilysin (MME).
Sequence Mass (Da): 19564
Sequence Length: 169
Subcellular Location: Secreted
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P31745 | QLHVNKARRVYIL | Function: Smooth muscle-contracting peptide.
PTM: Neurotensin is cleaved and degraded by Angiotensin-converting enzyme (ACE) and neprilysin (MME).
Sequence Mass (Da): 1610
Sequence Length: 13
Subcellular Location: Secreted
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P24787 | MAEPSLPLSFLCLLALSSACYIQNCPRGGKRALGDTALRQCLPCGPGNRGRCFGPGICCGAELGCYLGTAETRRCAEEDYMPSPCQAGGQPCGSDGRCAANGVCCSADTCAMDAVCLEEGSEQAEEAAEKNLTVLDGAAGDLLLRLMHLANRQQQGKQPGL | Function: Vasotocin is an antidiuretic hormone.
PTM: Seven disulfide bonds are present in neurophysin.
Sequence Mass (Da): 16693
Sequence Length: 161
Subcellular Location: Secreted
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P11858 | CYIQNCPRGGKRSYPDTEVRQCIPCGPGNRGNCFGPNICCGEDLGCYIGTPETLRCVEENYLPSPCEAGGKPCGAGGRCAAPGVCCNDQSCTMDSSCLDEDSERQRVSPDQNMTQMNGSASDLLLRLMHMANRQQQQTKHY | Function: Vasotocin is an antidiuretic hormone.
PTM: Seven disulfide bonds are present in neurophysin.
Sequence Mass (Da): 15322
Sequence Length: 141
Subcellular Location: Secreted
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G2TRK9 | MGQVLSICSSKSKEKKVVNEKPTVKPKPAVNVQKPAKAITKASSPPRTGRKLAETGNTSNKEHLSPTEAARVAAEKRNIEKKKGNGKLGRQLEKERAKPMKEHLQDISTQRQQEREQIKWD | PTM: Myristoylated.
Location Topology: Lipid-anchor
Sequence Mass (Da): 13535
Sequence Length: 121
Subcellular Location: Cell membrane
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Q8K120 | MGAASCEDEELEFKLVFGEEKEPPPLGPGGPGEELDSEDTPPCCRLALGEPLPYGAAPIGIPRPPPPRPGMHSPPPRPAPSPGTWESQPARSVRLGGPGGNAGGAGGGRVLECPSIRITSISPTPDPPTSLEDTSETWGDGSPRDYPPPEGFGGYREAGGQGGGAFFSPSPGSSSLSSWSFFSDASDEAALYAACDEVESELNEAASRFGLSSPLPSPRASPRPWTPEDPWSLYGPSSGGRAPEDSWLLLSAPGPVPASPRPASPCGKRRYSSSGTPSSASPALSRRGSLGEEGPEPPPPPPLPLVRDPSSPGPFDYVGAPPTESIPQKTRRTSSEQAVALPRSEEPPSCNGKLPSGTEDSVAAPGALRKEVAGMDYLAVPSPLAWSKARIGGHSPIFRTSALPPLDWPLPSQYEQLELRIEVQPRAHHRAHYETEGSRGAVKAAPGGHPVVKLLGYSEKPLTLQMFIGTADERSLRPHAFYQVHRITGKMVATASYEAVVSGTKVLEMTLLPENNMAANIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHVPQGGGKVVSVQAASVPIECSQRSAQELPQVETYSPSACSVRGGEELVLTGSNFLPDSKVVFIERGPDGKLQWEEEAAVNRLQSSEVTLTLTIPEYSNKRVSRPVQVYFYVSNGRRKRSPTQSFKFLPVVFKEEPLPDSSLRGFPSTSGPPFGPDVDFSPPRPPYPSYPHEDPAYETPYLSEGFGYSTPALYPQTGPPPSYRSGLRMFPETGGTTGCARLPSVSFLPRPFPGDQYGGQGSSFALGLPFSPPAPFRPPLPSSPPLEDPFHPQSAIHPLPPEGYNEVGPGYTPGEGASEQEKARGGYSSGFRDSVPIQGITLEEVSEIIGRDLSGFPARPGEEPPA | Function: Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems. Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 . Along with NFATC3, involved in embryonic heart development . Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function . Transactivates many genes involved in heart physiology. Along with GATA4, binds to and activates NPPB/BNP promoter . Activates NPPA/ANP/ANF and MYH7/beta-MHC transcription (By similarity). Binds to and transactivates AGTR2 gene promoter . Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation . In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during a developmental critical period when auditory neurons depend on afferent input for survival . Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP). Plays a role in adipocyte differentiation. May be involved in myoblast differentiation into myotubes (By similarity). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription. Binds to PPARG gene promoter and regulates its activity (By similarity). Binds to PPARG and REG3G gene promoters .
PTM: Phosphorylated by NFATC-kinases; dephosphorylated by calcineurin/PPP3CA. Phosphorylated on Ser-168 and Ser-170 by MTOR, IRAK1, MAPK7/ERK5 and MAPK14/p38, on Ser-213 and Ser-217 by MAPK8 and MAPK9, and on Ser-289 and Ser-344 by RPS6KA3 . Phosphorylated by GSK3B (By similarity). Phosphorylation by GSK3B markedly increases NFATC4 ubiquitination (By similarity). Phosphorylation by MAPK8/JNK1, MAPK9/JNK2 and RPS6KA3 may stimulate NFATC4 transcriptional activity. Phosphorylation at Ser-168 and Ser-170 is stimulated by UV irradiation (By similarity).
Sequence Mass (Da): 95782
Sequence Length: 901
Domain: Rel similarity domain (RSD) or Rel homology domain (RHD) allows DNA-binding and cooperative interactions with AP-1 factors.
Subcellular Location: Cytoplasm
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A4IT49 | MKLLGISGTLVGTKTCILVEQVLVEAKRICPEVDIQLLDLKDYQVEFCDGRQQSSYNEDTQKVIELVSVADCYVIGTPIFQGSITGALKNLFDLISPQALRHKVMGFVANGGTYQHYLVIENQLKPIASFFRAFVAPGSVYAHTDHFNEKNELVDPEVRERVAQLAWEVVHMHWSLKSGGVHAHR | Function: Involved in the pathway of tryptophan degradation. Reduces FAD/FMN to FADH(2)/FMNH(2), which are subsequently used for the hydroxylation of anthranilate. It can reduce either FAD or flavin mononucleotide (FMN) but prefers FAD. The enzyme has a slight preference for NADPH as acceptor.
Catalytic Activity: FADH2 + NAD(+) = FAD + 2 H(+) + NADH
Sequence Mass (Da): 20725
Sequence Length: 185
EC: 1.5.1.45
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Q8NET5 | MENQPVRWRALPGLPRPPGLPAAPWLLLGVLLLPGTLRLAGGQSVTHTGLPIMASLANTAISFSCRITYPYTPQFKVFTVSYFHEDLQGQRSPKKPTNCHPGLGTENQSHTLDCQVTLVLPGASATGTYYCSVHWPHSTVRGSGTFILVRDAGYREPPQSPQKLLLFGFTGLLSVLSVVGTALLLWNKKRMRGPGKDPTRKCPDPRSASSPKQHPSESVYTALQRRETEVYACIENEDGSSPTAKQSPLSQERPHRFEDDGELNLVYENL | Function: May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking.
PTM: N-glycosylated.
Location Topology: Single-pass type I membrane protein
Sequence Mass (Da): 29686
Sequence Length: 270
Domain: The ITAM domain displays no close similarity to any existing ITAMs, except for four conserved positions. The phosphorylated ITAM domain binds ZAP70 and SYK.
Subcellular Location: Cell membrane
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Q8R4V1 | MESWLLRRGARVRCLHPPSWLPAWCFLCLLPVPQTLQLTGLVSLTHTSLPIMVSLANTDVFFSCRIEDFTRLQRDLPVKLFHTDIHGRRRWEKQINCQHRPGMENHTRDCMVKLSQANTSATGIYYFIVEGEETYQSDGVVILVRDTVYQPPAFKVQEALMLGFTSLMSVLGVLGTALLLWKKKQISVLGKHTAKTCSGLKSTVGTTKPPAESVYTSLQRRETEVYACMKEETGSPVFSQSPATKEKLNRFEDDNEFNLVYENL | Function: May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters (By similarity). May be involved in the regulation of B-cell, but not T-cell, development.
PTM: N-glycosylated.
Location Topology: Single-pass type I membrane protein
Sequence Mass (Da): 29988
Sequence Length: 264
Domain: The ITAM domain displays no close similarity to any existing ITAMs, except for four conserved positions. The phosphorylated ITAM domain binds ZAP70 and SYK.
Subcellular Location: Cell membrane
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P32860 | MFKSVAKLGKSPIFYLNSQRLIHIKTLTTPNENALKFLSTDGEMLQTRGSKSIVIKNTDENLINHSKLAQQIFLQCPGVESLMIGDDFLTINKDRMVHWNSIKPEIIDLLTKQLAYGEDVISKEFHAVQEEEGEGGYKINMPKFELTEEDEEVSELIEELIDTRIRPAILEDGGDIDYRGWDPKTGTVYLRLQGACTSCSSSEVTLKYGIESMLKHYVDEVKEVIQIMDPEQEIALKEFDKLEKKLESSKNTSHEK | Function: Involved in iron homeostasis within the mitochondrion where it is involved in the assembly of iron-sulfur proteins . Together with BOL3, required during the last step of iron-sulfur protein assembly when the iron-sulfur cluster is inserted into the target protein . Required for protecting iron sulfur clusters from oxidative damage .
Sequence Mass (Da): 29174
Sequence Length: 256
Domain: The CxxC motif may bind a [4Fe-4S] cluster.
Subcellular Location: Mitochondrion matrix
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P25207 | MDGDSSTTDASQLGIAGDYIGGSHYVIQPHDDTEDSMNDHEDTNGSKESFREQDIYLPIANVARIMKNAIPQTGKIAKDAKECVQECVSEFISFITSEASERCHQEKRKTINGEDILFAMSTLGFDSYVEPLKLYLQKFREAMKGEKGIGGTVTTGDGLSEELTEEAFTNQLPAGLITTDGQQQNVMVYTTSYQQISGVQQIQFS | Function: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
Sequence Mass (Da): 22585
Sequence Length: 205
Domain: Can be divided into 3 domains: the weakly conserved A domain, the highly conserved B domain thought to be involved in subunit interaction and DNA binding, and the Glu-rich C domain.
Subcellular Location: Nucleus
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P25208 | MTMDGDSSTTDASQLGISADYIGGSHYVIQPHDDTEDSMNDHEDTNGSKESFREQDIYLPIANVARIMKNAIPQTGKIAKDAKECVQECVSEFISFITSEASERCHQEKRKTINGEDILFAMSTLGFDSYVEPLKLYLQKFREAMKGEKGIGGAVTATDGLSEELTEEAFTNQLPAGLITTDGQQQNVMVYTTSYQQISGVQQIQFS | Function: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
PTM: Monoubiquitination at Lys-140 plays an important role in transcriptional activation by allowing the deposition of histone H3 methylations as well as histone H2B monoubiquitination at 'Lys-121'.
Sequence Mass (Da): 22831
Sequence Length: 207
Domain: Can be divided into 3 domains: the weakly conserved A domain, the highly conserved B domain thought to be involved in subunit interaction and DNA binding, and the Glu-rich C domain.
Subcellular Location: Nucleus
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P25210 | MDADGSTTDASQLGITGDYIGGGHYVLQSSDGDAEGSLASGDHDESCGSKDPYREQDIYLPIANVARIMKTSIPSSGKIAKDAKECVQECVSEFISFITSEASERCHQEKRKTINGEDILFAMSTLGFDSYVEPLKQYLQKYRESMKGEKGINATVVTTTDAIPEELTEESFSGPLATSIITADGQQQNVMVYTTAYQQIPGVQPIQFT | Function: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
Sequence Mass (Da): 22676
Sequence Length: 209
Domain: Can be divided into 3 domains: the weakly conserved A domain, the highly conserved B domain thought to be involved in subunit interaction and DNA binding, and the Glu-rich C domain.
Subcellular Location: Nucleus
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A1T2V5 | MTVTEQTTARGFPLLPSRLSRGSQATRTTDNTAAALLLTFTVIAILWANSPWAQSYSTLLETHIGFGFGDHHFEMTVKHLVNDALMTFFFFIVGLEVTREFTIGELTDRSRAAVPVVAAAAGLIVPAIVFLAFNPSGDNAHAWGVVISTDTAFLVGALAIIKPKFPARVRLFLLTLAVVDDVGALVAIAVFYSDAIQVGPLVVAVAVLVALALVRFLPVARGPAYAVLGVALWVALYLAGIHPTLAGVAVALLIPVFTPERRPVERAVDQIRAFRQSPNSQYARAASRSLRESISINERMQTAVGPAVSFVILPLFALVNAGVLLDGQSLMTALRSPLTWGVVAGLVIGKFVGITGATWLMRRTGLGVLAPGLTLRRIAGGAALSGIGFTISLFIVDIAISDSSRQDQARIGVLAASVLAFVFGWAIFRITDWLSPPEPVGLKLLRPVEPDRDHVRGRYDAPLVLVEYGDFECPFCSRATGAIDEVRAHFGDDLLYVWRHFPLERAHPRAFDAARASEAAALQGKFWEMAHELFDHQDDLEWSDMYRYAVAAGCDIEQFDQDVRVHSSKVLHRVTDDAEDAEAMDLNATPTLFVNGIRHKGPWDAASLIRALEAGRR | Function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
Catalytic Activity: 2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 66904
Sequence Length: 617
Subcellular Location: Cell membrane
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Q1D5J5 | MAQTPPTSEARPRPPVPTLFRVALAPIQAFFRLEAASGILLALCAVAAMVWANSPWAATYSAVFDARMTVGLAGVHAGFTIREFINDGLMTLFFFVVGMEIKRELSSGELRTFSRAVLPLIAAMGGMIVPAALYAAFNQGTPAQAGWAIPMATDIAFSIGCLTLVKTRVSHGLVVFLTALAIFDDIGGILVIALFYGSGLHVSWLVGALGVLAVLACLNHFQVRNGVAYALAGAALWYTMHHGGIHATLSGVVLGLFMPARPLRPGRHVLEELRLYVDRALQTAMDEATRGAQILYLEERLEELEPPLNRFVHLWHVPVAYGIVPLFALANSGISLEGMGWADLLRPLPLGIIAGLFVGKQVGIFLFTWGSLKLGVADRPGGATLPQLHGVAVVAGIGFTVALFVAGLAFPTQPELLTEAKLGILVGSLLSAVVGYALLRFVAKPAVPA | Function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
Catalytic Activity: 2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 47616
Sequence Length: 449
Subcellular Location: Cell inner membrane
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A1AK41 | MKRHLNMLREFSIPLISGVIVALVWANISPESYQHFDHDRNFGPFSFHFIVNDFFMVLFFGIAAAEITQSCLPGGDLYPLRKAVNPLLATIGGVVGPVLVYVVLNALMGDPSLLRGWGIPTATDIALAWLVASLVFGKRHPAISFLLLLAIADDAIGLAIIALFYPDPNLPAAPQWLVLVLSGMGAAALLRRGNAQSYWPYIILGGGLSWAGLFMAHLHPALALVFIVPFLPHPHREKKHLFEEDMRDLSPLASFEHEWKVMVDFGLFLFGLANAGVTFGSIGAATWLVLASLVIGKTGGIFFMGWLGRRLGYPLPSRVGGKELALVGLIAGIGLTVALFVAGEAFTDPARQGAAKMGALMSAGCAVLALAAGRIMNVKRIT | Function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
Catalytic Activity: 2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 41019
Sequence Length: 382
Subcellular Location: Cell inner membrane
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Q15N95 | MNQLQDKDRELAPLERKFNHFICSFEQFFKSQATASITLLLAAIAAMVIANSQWHEGYEEISHMAFSISLGDFAISHSLHTWVNDGLMVLFFFLLGLEIKYECLVGDLKDFRDSSLVIAMAIGGMLLPAGIYAGVALTGVDEALRGWGIPMATDTAFALGILALLGSKAPRSAAVTLSALAIVDDMGAVAVIGLFYTENIHLTSLMYAGLTLGGLFALNVLGFRRPIFYLVGGILLWWFVLQSGVHATAAGILAALAVPTKPYAQSTWFATNMRSVLNRFEKNDRKDKSILEQQDQHELVEQAQDIAAMTTTPIQRWGHVLNRPVSLIILPIFAFINAGVALPDDLSKIFDSVVFIGVASAMVLGKVIGISVFAWIAVKSGFSRLPNGLAFGHVFALACLAGVGFTMSLFIASLGFAGHPELLAQAKLGILAGSVIAAIIGTTLFLMIKHKVHEEPKDERHNKAGLPQTDQE | Function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
Catalytic Activity: 2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 51017
Sequence Length: 472
Subcellular Location: Cell inner membrane
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Q88NS2 | MEGLQPVRSLFTRFFQLEAASGLLLIAAAVLALIINNSPLSYLYGGLLEVPVAVQVGALNIAKPLLLWINDGLMALFFLLIGLEVKREVVDGHLSKPSQVILPATAAVGGMVVPALIYWFINRDNPAAVAGWAIPTATDIAFALGVLALLGKRVPVSLKLFLMTLAIIDDLGAIIVIALFYSGTLSSVSLLLAAACLLVLVAMNRLGVIKLGPYMIVGLILWVCVLKSGVHATLAGVALAFCIPLRTRNAESSPLLALEHALHPWVAYAILPIFAFANAGVSLAGMTVDSFTHPVPMGITIGLLLGKTVGVFGLTWVAVKLRLAALPAGAGWGQILGVAILCGIGFTMSLFVGSLAFAPGSSEYAGMDRMGILTGSFFAAVIGYAVTAMASRKTSIA | Function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
Catalytic Activity: 2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 41403
Sequence Length: 397
Subcellular Location: Cell inner membrane
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A1SRG6 | MSSRGKWSWLHSPITGGILLIIAATTALFWANLAPSLYHHAWHDALFSVSSGFSATIYSISLHQIVNEFLMAIFFFFIGLEMKRELLDDDLSTLKKAALPLFSALGGVVLPASIYYFFNAGTDTVNGWGIPMATDIAFALGVLAMVGSRVPLSLKIFLSALAIGDDLMAVLVIAIFYTEQIFVNELLVGFLGLIVLAVANKMGVRNRLVYYSIGLIIVWISFLASGVHATIAGVAVAFTIPSRREISMGNYLITAKGLLSGLDKERHNKADVLTKNAISSLREIRDLSYQASNPLQLKEEALHPISALFIVPLFALGNAGVIVDDSMLAELTNPIVLGIAAGLIIGKPLGIFLFAKLLTLLKLGQLPEGVTWRHIIGTGFLAGMGFTMSLFISDLAFSEPEQKIVAKVAVLLASIISGIVGYLILISAPVIKKDNKLNS | Function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
Catalytic Activity: 2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 47291
Sequence Length: 439
Subcellular Location: Cell inner membrane
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Q0SG15 | MTVEQSSPTTLRRLSARLALIRDDTDDDKLSAGFLLVATILALVWANIGDSYESFWHTPVTIQISDNSISLDLKHWVNDGLMTLFFFVVGLEVKRELTIGELTDRARAAVPLLAAIAGLALPAVLFLILNPSGDEATAWGVVVSTDTAFVLGALALVGPRCPARLRVFILTLAVADDIGALALIAFFYTDDLRLGPLLLGCVGLLLIIQLRKLEVWRGVAYFIVAAGTWVAFYESGVHPTLVGVLIALILPVYPPRRSEVERAGELTRAFRQSPNSDYARAAQLGVLRAVSVNERLLRFYQPYTAFLVVPIFALANAGVVITGQTLADAARSPLAWGIVLGLVVGKLVGITAATALFSKLRPGSLPPGLTLSQIAGGSALAGIGFTISLFIVDLAIDSPELANEARVGVLTAAVIATVLGWALFRLSDTVHPPTEVVGLTLLRPVDPGRDHLRGPADAPLTLVEYGDFECPFCSKATGSIRDVRAHFGDELRYVFRHLPLDDVHPHARFAAQASEAAAAQGRFWEMHDHLFANSDALAEDEIFGYAAELGLDMDRFEEDIRRGTYVHRIDDDELDAESSDFRGTPTFYLGATGTDLARHSGPYDAATLIRKLEEARGADGAP | Function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
Catalytic Activity: 2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 67068
Sequence Length: 622
Subcellular Location: Cell membrane
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Q21JV7 | MSNETPKKFIPNEQNPMPRWEKKFNKILTPFERFVNRTTTGGLILMMAALIALALANSPLAHHYLHALHVPLGLNLGDWRIEKSLHHWVNDGLMALFFFVVGLELKREMLVGELAEIRKAVLPIVAAIGGMVIPAICYMSLNLNDETFRGWGIPMATDIAFALGVIALLASRVPKALITFLVALAIVDDLGAVVVIAVFYTQDLAWSFLIAGALLTCLLIFFNMIGIRKPSVYFFVGLILWFVFLKSGVHATLAGVITAFTIPAKPKFNTLTFSNRVQDILYKFRKGCEEDESILRNEHLSGLVQTLENGVVGVQTPLQRLEHSFHKPVAFFILPVFAIFNAGVTIDFGNAFQLFNHPITLGVVFGLLFGKFVGITGASWLAIRFGLCSLPNDTSMKHIIGASMLGSIGFTMSIFIAELAFVSQPEMIIQAKLGILLSSLVAGVAGYLWLHKLGGEKSRIGSSL | Function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
Catalytic Activity: 2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 50957
Sequence Length: 464
Subcellular Location: Cell inner membrane
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A9V2C1 | MHLFTYDLHHDVGGAENMLRLPLDRHERDYLPWERHIHALVVLLVKQGRMSVDELRRGVEGLPSSLAEQASYYEKWGLSVSRILTEKGTVSGHELEQGFLGVPTTDLPQVPRFQVGQRVMVRPFGTTFAYRQPHLRVPGYVHGAVGTIVELPGLFQDPMTGAYGERGTAQPLYRVAFSHRALWPEGAAHAEPGELEDGVVVDVSQPWLEALSEADYAQRLATLHRVAFTPDSNPPQAHKHHHHRHHHDHHHHHHHHHAMHAEHEAHTHDTRYGTEQAAVAKEAALDFPYQPWCEALVQTLTRRGVVRSDELHATLASLDALQNSGAGPQLVARAWSDAAFAEWLLTDAAAAAESLAIRTTNYDADPASAERVGGHRLFSHNHTELRVVANTDTVHNLVCCTLCSCYPTAILGLSPPWYKSKVFRARAVREPRRLLREEFGLVLPEARGIRVHDSTADLRYMVLPQRPQGTEGWSEEHLRTIVTRDSLLGTAVPRVD | Cofactor: Binds 1 Fe(3+) ion per subunit.
Function: NHase catalyzes the hydration of various nitrile compounds to the corresponding amides. Industrial production of acrylamide is now being developed using some of the enzymes of this class (By similarity).
PTM: Oxidation on Cys-403 is essential for the activity.
Catalytic Activity: an aliphatic amide = a nitrile + H2O
Sequence Mass (Da): 55604
Sequence Length: 496
EC: 4.2.1.84
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A0KG33 | MSDVIKKFLKLEAASGIILIMAAMLAMILANSGLAGSYQAFLDTQVQVRIAALDINKPLLLWINDGFMAVFFLLVGLEVKREMLEGALSSRVQATFPAIAAVGGMLAPALIYAFFNYSDEVARAGWAIPAATDIAFALGVMALLGKRVPVSLKVFLLALAIMDDLGVIIIIALFYTQQLSLTALAIGILATLTLLWMNRRGEDRISLYMLVGLVLWVAVLKSGVHATLAGVIVGFMIPLSGKRYASPLKQLEHALHPWSAYLILPLFAFANAGVSLEGIGLSALLSPVPLGIMLGLFIGKPLGVFTISWLAVKLGIAQLPNGVNFKQIFAVSILCGIGFTMSMFIASLAFEHGGLDYGSYSRLGILVGSTLAAIVGYLALRIALPNREADQSTEGL | Function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
Catalytic Activity: 2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 42171
Sequence Length: 396
Subcellular Location: Cell inner membrane
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Q21VA4 | MLKVIARRIDQFINSQSAGGVLLALSALVALVISNSPWRSYYQQFLQIPGSVKMGADWLLLSKPMLIWINDLWMAVFFFLVGLEIKRELLNGELASLKQAMLPAVAALGGMAVPALIYAAINWGEPVGLRGWGIPMATDIAFALGLLVLLGSRVPTSLKVFLTAVAIIDDLGAILVIAFFYTDNLSPTMLLAAGLGALVLLGLNRARVMAVGPYVVVGLVIWVCVLKSGIHATLAGVITALAIPLADGKGGSPLERAEHALQPWVAFLVLPVFAFANAGVSLQGVTLATLTQTVPLGIAFGLLIGKPIGVFGASWLLIRLTDAQLPDQCRWSQFFGVCVLCGVGFTMSLFIGSLAFEGADAAYEVQVKIGVLLGSLLSGAAGVALLLASRKAV | Function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
Catalytic Activity: 2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 41334
Sequence Length: 393
Subcellular Location: Cell inner membrane
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Q2IE76 | MNRADARRARPAPEGRPMSGPGPLPVRLDPPVDPARDHVLGEPGADLTLVEYGSYACPHCHVAHEVVAELRDRLGDRLRYVFRQRPIRAEAARPAAELAEAAGLDGERFWHAHDLLMRRGPSFAAGELDAIARELGLPPRERGAGPWEGAAARVREDVESARRSGVHLTPTFFINGRRYEGPWDAAALSEALLGSLGHRLHAATLDFARWAPSTGLLLVVATAIAVAIANSSAGAAFTAAWQAPLGLSLGGRGFALPLVQWVNDGLLTLFFLVVGLEIKRELTVGRLASWRAAALPMAAAIGGMVAPAALYLLVIPAGPLAGGWGTTISTDTAFAVAILVLLGDRVPVDLRVFLTAAVIVDDLVAIAVVALFYSGAISLPWLLAAAAVTALLAGLNRAAISAAPPYVALGALLWACLHAAGLHPTLAGVILAVVTPTRPPPDLRALTGQAQAVLEAELRRAREGVLRHGPSEPALRALDAIHDRIESPASKLLRTLDPWASYAVLPVFALANAGVAWVPGALDGRGRLVAAIVLGLVAGKPLGMFLAARLAVRAGLAVKPAAYAWRQLAGAGALAGIGFTMSLFIAGQAFPDPADFRAAKIAIFAASLLAGVLGALVLWPRRSPAAEAEALPAPEGSEVDAAGT | Function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
Catalytic Activity: 2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 67021
Sequence Length: 644
Subcellular Location: Cell inner membrane
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A0JR38 | MILSTQRLGRFMSPAPTPAPDAKPRTVLGYGSYAESLRIGEILRKETVGGALLVAAAVIALIWANSPVSDSYFALRDYKIGYEPWHLELSLGAWAADGLLAIFFFLVGLELKREFVAGDLRQLNKSIVPVAAAAGGVLVPALIYAAVNIYSPETLRGWAIPTATDIAFAVAVLAIIGSHLPSALRIFLLTLAVVDDLIAISIIAFFYSSDIQAAPLLLALIPLALYAFLAQRYRRFFGAHFMAAWAILLPLGIVTWALVHASGIHATVAGVLLGFAVPVLRSKASGGPEAGPGLAEIFEHRFRPISAGVAVPIFAFFSAGVAVGGWEGLGSALADPVAIGIIMALVLGKPIGIMGTTWILTKATRARLDGSFKWIDVFGVSLLAGIGFTVSLLVAELSFGHGSLHDDHAKVGILAASLLAAILATVVLRARNRQYRRAEELEKVDSDQDGIPDVYQHESRG | Function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
Catalytic Activity: 2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 48921
Sequence Length: 461
Subcellular Location: Cell membrane
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Q64T76 | MTVLRSMKDFSSMNITASILLFVTAIAAAVIANSPAASVYQEFLSHELHFRIGGFNLLSHAGHNLTMIEFINDGLMTIFFLMVGLEIKRELLVGELSSFRKAALPFIAACGGMVVPVVIYSMVCAPGTEGGQGLAIPMATDIAFSLGVLSLLGKRVPLSLKIFLTAFAVVDDIGGILVIAIFYSSHVAYEYLLWAALLYVLLYFIGKKGATNKIFFLVVGVVIWYLFLQSGIHSTISGVILAFVIPAKPQLNVGTYIERIRRIISTFPEMGANNIVLTNQQIAKLKEVESASDRVISPLQSLEDNLHGAVNYLVLPLFAFVNAGVMFSGEGEVIGGVTLAVALGLLAGKFLGIYSFTWLAVKSGLTPMPLGMNWKNISGVALLGGIGFTVSLFIANLSFGSAHPVLLNQAKLGVLSGTVMAGILGYLVLHWVLPQRR | Function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
Catalytic Activity: 2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 46904
Sequence Length: 437
Subcellular Location: Cell inner membrane
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G5EDM4 | MVHIPSDVTPPRLCVVEKLNGENEYGYNLHAEKGRGQFVGTVDPDSPAERGGLITGDRIFAVNGHSIIGENHKKVVERIKANPNRCEMLVISEEGAKWYNENNVQITLDLPNIERVSPMSKETPVFVPPPPPPTDAMPYLPRLAELNKGTPDQEFGFNLHAERGRGHFIGTVDAGGIGEKAGLEAGQRIVGVNGQLIYPTTGHKEVVALIKKDTMKTTLLVASEDVDKYHKDHNIAYSWDNVERVDTRPVINVETHHHHEEVSVPKSNGYDVPPLNPHSIQVNEEREISKMTTTTRTETITNSNSAYQYKESSTAYDAYATPPVDSNDLMDEVFGRVNLPGVTMSSHTEVLPPTDDISSVSSLSSHRESAVDVPVSHQYVPSYATESHQKHEQHSQTHHHHHQHQQPSPLSNGSSHGYAASSTSGYDDDDIYHLSAREARERLRMKNRKHHLHEMSLNEKYQLVSNM | Function: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression (By similarity). Anchors the amino acid transporter protein aat-6 to the apical cell membrane of intestinal cells, particularly in older animals, in order to maintain amino acid homeostasis . May play a role in promoting fertility .
PTM: Phosphorylated.
Sequence Mass (Da): 52066
Sequence Length: 467
Domain: The PDZ 2 domain is required for the interaction with the amino acid transporter protein aat-6.
Subcellular Location: Cell projection
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Q5ZM14 | MSSAPPGPAAPRLCCMEKGPDGYGFHLHGEKGKPGQYIRLVEAGSPAERSGLRAGDRLLEVDGTNVERESHQQVVERIRAAAGAVRLLVVQPQPEEQPPKTHSDPDGEAQREPPAAETPAAERSGPEERELRPRLCRIKKGPNGYGFNLHSEKSRPGQYVRAVDPDSPAEAAGLRAQDRIVEVNGTSVEGKQHADVVAAIKAGGDETKLLVVGVLADEFFKKCRVVPSEAHLAGPLPEPMANGDVEKENGGEPRLNSVSERPPSPALATSPEGSETHSEPDTQEGDKRSSAPSSLLDLDIPLAVAKERAHQKRTSKRAPQMDWSKKNELFSNL | Function: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. May enhance Wnt signaling (By similarity).
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 35805
Sequence Length: 333
Subcellular Location: Endomembrane system
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O14745 | MSADAAAGAPLPRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQGAGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIRSVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKCRVIPSQEHLNGPLPVPFTNGEIQKENSREALAEAALESPRPALVRSASSDTSEELNSQDSPPKQDSTAPSSTSSSDPILDFNISLAMAKERAHQKRSSKRAPQMDWSKKNELFSNL | Function: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa.
PTM: Phosphorylated on serine residues.
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 38868
Sequence Length: 358
Subcellular Location: Cytoplasm
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Q15599 | MAAPEPLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEHVEGPLPSPVTNGTSPAQLNGGSACSSRSDLPGSDKDTEDGSAWKQDPFQESGLHLSPTAAEAKEKARAMRVNKRAPQMDWNRKREIFSNF | Function: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 . May also act as scaffold protein in the nucleus.
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 37414
Sequence Length: 337
Subcellular Location: Endomembrane system
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Q3T0X8 | MASTFNPRECKLTKQEGNSYGFFLRIEKDTDGHLVRVIEKGSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLLVLDGDSYEKAMKKQVDLKALGQSQEPSLNDKKAPSVMNGGAQMWMQPRLCYLVKEGGSYGFSLKTVQGKNGVYMTDIKPQGVAMKAGVLADDHLIEVNGENVEDASHEEVVEKVKKSGSRVTFLLVDKETDKHHSEQKIKVKRETASLKLLPCQPRVVEMKKGSNGYGFYLRESPEQKGQIIKDIDPKSPAEKAGLKNNDLVVAVNGKSVESLDHDSVVEMIRKGGDQTSLLVVDKETDNIYKLAGFSPFFYYQSQELPNGSVKEVPAPTPAPLEVSSPETTEEVGDHKPKLCRLARGEDGYGFHLNAVRGQPGSFVKEVQKGGPADLAGLEDEDVIIEVNGVNMLDESYEKVVDRIQSSGKTVTLLVCGKKAYDYFQAKKIPIVSSMADPLDDDPDPDEGRLEGSEQNSHMAEERERAHSTASHSSSNSEDTEM | Function: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with NHERF1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity).
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 57175
Sequence Length: 520
Domain: The PDZ 2 and 3 domains seem to be involved in the interaction with SLC26A3.
Subcellular Location: Membrane
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Q5T2W1 | MTSTFNPRECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLLVLDGDSYEKAVKTRVDLKELGQSQKEQGLSDNILSPVMNGGVQTWTQPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKLLPHQPRIVEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTPTSLEVSSPPDTTEEVDHKPKLCRLAKGENGYGFHLNAIRGLPGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLVCGKKAYDYFQAKKIPIVSSLADPLDTPPDSKEGIVVESNHDSHMAKERAHSTASHSSSNSEDTEM | Function: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with NHERF1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity).
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 57129
Sequence Length: 519
Domain: The PDZ 2 and 3 domains seem to be involved in the interaction with SLC26A3.
Subcellular Location: Membrane
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C0QKK8 | MRKIAIYGKGGIGKSTTTQNTVAGLVEAGHKIMVVGCDPKADSTRLLLNGLAQKTVLDTLREEGEDVVLEDVLKLGYGGTMCTESGGPEPGVGCAGRGIITSINLLEQLGAYENEELDYVFYDVLGDVVCGGFAMPMREGKAQEIYIVVSGEMMAMYAANNICKGIVKFAESGGIRLGGLICNSRAVDFEKDMIEALAEKLGTQMIHFIPRENVVQRAEINRKTVIEYEPEHSQADEYRMLAKKINENEKYVIPTPIEIEELEELLVTYGIAS | Cofactor: Binds 1 [4Fe-4S] cluster per dimer.
Function: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
PTM: The reversible ADP-ribosylation of Arg-97 inactivates the nitrogenase reductase and regulates nitrogenase activity.
Catalytic Activity: 16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin] = 16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate
Sequence Mass (Da): 29764
Sequence Length: 273
EC: 1.18.6.1
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Q94AH3 | MAESSGSWRDSYKGMSSDNIKGLVLALSSSLFIGASFIVKKKGLKKAASTGTRAGVGGYSYLYEPLWWIGMTTMLLGEIANFAAYAFAPAILVTPLGAVSIIISAVLAHIILREKLHIFGILGCALCVVGSTTIVLHAPQEREIDSVIEVWNLATEPAFMFYASLVIGAAVFLIIRFVPQYGQTNVMVYIGICSLVGSLSVMSVKALGIALKLTFSGTNQLFYPQTWIFTLVVLTCVVTQLNYLNKALDTFNTAIVSPIYYVMFTSLTILASVIMFKDWDRQNGTQIVTEICGFVTILSGTFLLHRTKDMVEGSSVILPLRISKHINEEEGIPLRRQESLRSP | Function: Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity).
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 37473
Sequence Length: 343
Subcellular Location: Cell membrane
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Q0D2K0 | MELRVSNTSCENGSLLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVDGGFGYLKDAMWWAGFLTMAAGEVANFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKDTGFIVFAVLLLVSCLILIFVIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNRALDIFNTSLVFPIYYVFFTTVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIRLEDKNVLVDNIELASTSSPEEKPKVFIIHS | Function: Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 44005
Sequence Length: 404
Subcellular Location: Membrane
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Q8BZF2 | MELRVANANGSCENGSIVSLYCSSQEVLCQIVRGISPEEPYNATLITWQERVRKKYGFYIGVGLAFLSCFLIGTSVILKKKGLIRLVATGATRAVNGGYGYLKDPMWWAGMATMSAGEVANFGAYAFAPATVVTPLGALSVLISAIFSSYCLGESLNLLGKLGCVICMAGSTVMVIHAPKEEKVTTVAEMASKMKDTGFIVFAVLLVVSCLILIFIVAPRYGQRNILIYIIICSVIGSFSVTAVKGLGVTIRNFFQGLPVVRHPLPYILSLILGLSIIIQVNFLNRALDIFNTSLVFPIYYVFFTTVVVASSIVLFKEWYTMSAVDIVGTLSGFVTIILGVFMLHAFKDLDINQISLPHTHKNPTPAPAPEPTVIKLEDKNVLVDNIELASTPSPQQKPKVFMTDS | Function: Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway (By similarity).
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 44059
Sequence Length: 406
Subcellular Location: Membrane
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F4JKQ7 | MVYSSGSWRDAYKGMSSDNVKGLVLALSSSIFIGASFIVKKKGLKKAGASGLRAGSGGYSYLLEPLWWIGMITMIVGEIANFAAYAFAPAILVTPLGALSIIISASLAHIILQEKLHTFGILGCALCIVGSVTIVLHAPQEQDIVSVLEVWNLATEPAFLFYAAAVVGAAIVLIVQFIPLYGQSHVMVYIGVCSLIGSLSVMSVKALGIALKLTFSGTNQLGYPQTWVFTVIVLFCVITQMNYLNKALDTFNTAVVSPIYYVMFTSLTILASVIMFKDWDRQSGTQIMTELCGFVTILSGTFLLHTTTDMVDGESKGNLSSEEDSHLLLRIPKHSEDSNGFVQDGIILSLRRQESAKSPRPARQNKQLEDDLEAVPLRRQESSLRS | Function: Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity).
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 41861
Sequence Length: 386
Subcellular Location: Cell membrane
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Q8GWX2 | METDNGKGLILAVASSVFIGSSFILKKKGLKRAGAIGTRAGYGGYTYLLEPLWWAGMVTMIVGEAANFVAYIYAPAVLVTPLGALSIIISAVLAHFLLKEKLKKMGVLGCVSCIVGSVVIVIHAPKEQTPNSVEEIWNLATQPAFLIYVAITMSIVLALILHFEPLCGQTNILVYIGICSLMGALTVMSIKAIGIAIKLTMEGVSQIGYPQTWLFVMVAVTCVVTQLIYLNKALDTFNAAIVSPVYYVMFTTLTIVASAIMFKDWSGQDAASVASELCGFITVLTGTMILHGTREEEQQQASSEHVRWYDSRKSMNEEHLVSLYSPEY | Function: Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity).
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 35580
Sequence Length: 328
Subcellular Location: Cell membrane
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Q8RWF4 | MGEWVIGAFINIFGSVAINFGTNLLKLGHNERERLALQDGGGKMPLKPIIHNQTWRVGILVFLLGNCLNFISFGYAAQSLLAALGSIQFVSNIAFAYVVLNKMVTVKVLVATAFIVLGNVFLVAFGNHQSPVFTPEQLAEKYSNVTFLVYCGILILIVAVHHFLYRKGEVLISTPGQEISSYWKMLLPFSYAVVSGAIGSCSVLFAKSLSNLLRLAMSSSYQLHSWFTYSMLLLFLSTAGFWMTRLNEGLSLYDAILIVPMFQIAWTFFSICTGCIYFQEFQVFDALRTTMFILGMMCVFIGISLLAPDDTRGNETKDNSSSLDSIVSSSVPTEEDRLIPQSSEDGHSKDTRVVVQGMYMKAADLIAKTKTACLAALGFGEDSINASAILVMPMVSSKITGFRGNGLERAKILSMRGSGWSKLAMEEEGTRMLEKTISSKA | Function: Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity).
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 48409
Sequence Length: 441
Subcellular Location: Cell membrane
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Q8RWH8 | MWESICLTLAATAGNNIGKVLQKKGTIILPPLSLKLKVLRAYAENKPWALGFLMDIVGALLMLRALSLAPVSVVQPVSGCGLAILSVFSHFYLKEVMNVFDWIGITVAGIGTIGVGAGGEEQEASLISVFQLLWLALVVAILFVLLNAWLHIFKRQRREQELGEYEVVEEIIYGLESGILFGMASVVSKMGFVFVEQGFSTMFIPMCISISICCSGTGFFYQTRGLKHGRAIVVSTCAAVASIVTGVVAGMFALGEKLPTSPSGRLLLLLGWLLIMLGVVLLVTSSRLIRHLPRSFRRSRQTSLERGFNIRRTTSHTPKDTNPSAVIQAATLHHLLSSPSKDKD | Function: Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity).
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 37388
Sequence Length: 344
Subcellular Location: Cell membrane
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G5EED4 | MARTKCKTKTVANPRTGVRKTAKDLSEPVRQDAVSRRRPTTLPFVGNTSSRPRVFYDVLAKKNVVFPNVKAEYHYRVRNAPKIDPKNFGTTLPICYSSIGPAKTLELRPLGRLPPHIIKALNDHYVQLTRGSMVPAADLYNNGDHPAEQRIPTMLNENEYLRLIQELEEEEKSKQFSATSSSAPHVNPYSAQHLVNGEIIGIFVIYGTGLVTRAVCSQTREMFTAHVLPEWKASKVIDVIRRLQIPTDISSMTADEIRLSELCISKRMEIIKSNDRYILMNPCESATIHSYATERLDEITENDVMSIYQKVVEIVRFCHSRKVILQNFKPRSFYLKKDAHNKWVVRPCFLQDMSCEEDQSEAQFTRRSVCVPFMAPEMLTAESRTHHSYSTELWGLGVLLYILLTGKYPFHENSMPLLFRTIKFKQHRWPFNFISSKSRNIVNMLLKKAPATRMNLEDLWNQVNGDFPEIRCRSNIILKKQDMIVKMDLFEMYYNTYKDRLLPKNVLPMYEEMKACRNDSTILTEMAKRDFRSIQEQMKRRIETKPTEYQTLVMQVRLQQINQLFFEKEVSQAQKQHRAPRLVQLKCSDISKELLLPGDIYPISEHYHPSQQPVDKVVYKLLSDANSLAFPTVMKGTVPKSYPPPVFKGLDISPS | Function: Adapter protein that regulates different signaling pathways (By similarity). Required for larval development and viability . Involved in negatively modulating pmk-1 p38/MAPK signaling . Involved in innate immunity, acting either in a manner dependent upon, or independent of, the pmk-1 or pmk-3 p38/MAPK pathways . Has a protective role in response to infection by the Gram-negative bacterium P.aeruginosa, acting by negatively modulating expression of cebp-1, and regulating the pmk-1 p38/MAPK pathway, leading to activation of transcription factor skn-1 . Required to prevent P.aeruginosa toxin ToxA-mediated lethality, probably acting via modulating the effects of translational inhibition caused by the toxin . By regulating the up-regulation in the epidermis of antimicrobial peptides nlp-29 and nlp-31, plays a role in resistance to fungal infection .
Sequence Mass (Da): 75748
Sequence Length: 655
Domain: The protein kinase domain is predicted to be catalytically inactive.
Subcellular Location: Nucleus
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O16262 | MELDHTPPPSVLNDNCSASYMTPYATVIAMSGLYLLAIFYFCKKSKKMCQPMSDSIYPYQKRLTQLERELKNYLIDEESIEVDDFQIGQTADGFIFRGGVFPKTRNRFNAKVTTAVKISFPIVSKSISLLEDALRLSKLDHPNLIRLLAVSQLSFTVFRPMIALEWLPGGTLADYFQFKVREKDDSERSPIQLKDMLSILYQVSQALKYIHSQLDEFGQELTHGRIFTRNVLVTEPDLRKCEVKLGDFGDAPMGLEYSTPIIAYMPPEILCCAERIPPHRPENDVWMFGVFIWECLTLGAQPHFRKSVEEIKKSFRLPDRGLSCPPTCPLDVWTLVSDCLSEPHMRPRFASTTNASITSRLSELHHIVSPALFLYAIPNQSVCTCIEHHCQSVIHY | Function: Pseudokinase which plays a role in resistance to fungal infection by promoting expression of antimicrobial peptides (nlp-29, nlp-31, nlp-34, cnc-1, cnc-2 and cnc-4) in the epidermis. In addition, up-regulates nlp-29 expression upon physical wounding and in response to phorbol ester PMA treatment.
Location Topology: Single-pass membrane protein
Sequence Mass (Da): 45182
Sequence Length: 396
Domain: The protein kinase domain is predicted to be catalytically inactive.
Subcellular Location: Membrane
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Q8LBA0 | MDTTLSPAVEAEQIADSTIDTVSRLIAGVFSGALTGIFAMAGAFTGAVTGAVAGRAAQYGVLRGAALGAVAGAILSVEVLEASRAYWYLELSGSRGPSSMADFVEQLFRGRLVDEQLMSTMINSHHWQLRISDVSYEEREDVYGELEARGLSGDSLRKLPCYIMSSEMVRRQVTHCTICLQDIKTGEITRSLPKCDHTFHLVCVDKWLIRHGSCPICRQAVKD | Function: May be involved in the early steps of the plant defense signaling pathway. Does not display E3 catalytic activity.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 24262
Sequence Length: 223
Subcellular Location: Membrane
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L7NCQ1 | MYSWYFPKDSPSTGLGHRHDWEHVIVWIDNPEVPEPKILGVTPSAHSGYSSQVPPDADKVDGSSVKVKYLSKWPINHALESTGEGGDFQDLIMWTQMTDAAREGLSKTGWGKANVPMVDGNFEAKLGKAWPFGEKK | Function: Secreted effector that contributes moderately to virulence during infection by P.capsici. Causes only small yellow areas at 3 days after inoculation of host C.annuum leaves; these areas expand somewhat and became necrotic at 7 days after inoculation. Leads only to chlorotic areas, without necrosis at 7 days after non-host N.benthamiana leaves infection.
Sequence Mass (Da): 15085
Sequence Length: 136
Domain: The structure of NLP effectors is remarkably conserved with a high level of conservation of a central hepta-peptide motif GHRHDWE.
Subcellular Location: Secreted
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L7NCS2 | MYSWYFPKDSPSTGMGHRHDWEHAIVFIDNPDVPEPKILACSVSSHAGYKKYNPCPPWVIDGTSLKVRYKHGWPLNHDLDTTGDAGTFQDLIMWDQMTEDARRALNSVHFGSANTPFNDGNFKPKLEKAWPF | Function: Secreted effector that contributes moderately to virulence during infection by P.capsici. Causes only small yellow areas at 3 days after inoculation of host C.annuum leaves; these areas expand somewhat and became necrotic at 7 days after inoculation. Leads only to chlorotic areas, without necrosis at 7 days after non-host N.benthamiana leaves infection.
Sequence Mass (Da): 15095
Sequence Length: 132
Domain: The structure of NLP effectors is remarkably conserved with a high level of conservation of a central hepta-peptide motif GHRHDWE.
Subcellular Location: Secreted
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L7NCR0 | MQLRAFISVFASLACVNAAVIDHDQVVPFAQPTPTTTLQTLAVQYKPQIYIANGCHPYPAVDEDGNTSGGLKPTGSQSAGCKGSGYGSQIYGRAVAYEGVYAFMYSWYMPKDETLPGLGHRHDWEACVVWLDSLENPNVVALSASYHSTYLTYYPPDSDYLDGNSAKIEYSTSWVILDHLLSATSTSGETQDLIMWDQLTDAARTALEDTDFGDANVPFKDANFETKLANAYYT | Function: Secreted effector that contributes to virulence during infection by P.capsici. Induces distinct chlorosis at 3 days after inoculation of host C.annuum leaves, and all the chlorotic areas gradually turn brown and become moderately necrotic at 7 days after inoculation. Leads only to chlorotic areas, without necrosis at 7 days after non-host N.benthamiana leaves infection.
Sequence Mass (Da): 25647
Sequence Length: 234
Domain: The structure of NLP effectors is remarkably conserved with a high level of conservation of a central hepta-peptide motif GHRHDWE.
Subcellular Location: Secreted
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A0A6G7KUU3 | MSPWEAKWIRHSDVRPFPQPEPMTVEEKVAVMLKPELHLSSGCHPYPAVNDLGETNGGLKTTGAPSGMCKGSGWGSQFTVDTHHLEASGPSCTRGTFQKTCRRHTSGIATTGST | Function: Probable secreted effector that may act as a pathogen-associated molecular pattern (PAMP) recognized by the plant immune system . Seems not to induce necrosis, neither in several susceptible or resistant Vitis species nor in the dicot model plant Nicotiana benthamiana .
Sequence Mass (Da): 12265
Sequence Length: 114
Domain: The structure of NLP effectors is remarkably conserved with a high level of conservation of a central region containing the conserved undecapeptide motif AIMYAWYFPKD and heptapeptide motif GHRHDWE.
Subcellular Location: Secreted
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L7NCQ4 | MKFVVFLCAIAAVVATIQGQEQQQQQQLPATIDHDQVKPFPQPQPVTISERAAMKFKPQLHVVDGCHPYPAVNDAGETGGGLKTTGSPTAGCKGSGWGSQVYGRSTWHRDVWAIMYSWYFPKDSPSTGLGHRHDWEHVIVWISNPDVPNPTILAVTPSAHSGYSKYAPPSADTVDGTSIKVRYESTYPMNHATDVTTEAGAFQDLIMWDQMTDAARNALNTVSFGDANVPMNDGNFVPKLDKAWPF | Function: Secreted effector that contributes strongly to virulence during infection by P.capsici. Causes large necrotic areas in both host C.annuum and non-host N.benthamiana.
Sequence Mass (Da): 26931
Sequence Length: 246
Domain: The structure of NLP effectors is remarkably conserved with a high level of conservation of a central hepta-peptide motif GHRHDWE.
Subcellular Location: Secreted
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A0A6G7KUY0 | MSPWEAKWIRHSEVRPFPQPEPITVEEKVAVMLKPEIHVKNGCHPYPAVNDLGETNSGLKTKGAPSGMCKGSGWGSQVYGRHALFKGVWAIMYSWYFPKDMPSTDFGHRHDWEHVIVWIEKPVVENVKILAVTPSAHDGYSKQVPPNPGHLNGLAAKINYESKWPINHALEPTGLGGEKQDLILWEQLSSNARHALNIVHWGDANTPFNDYVFMGKLEKAFPL | Function: Probable secreted effector that may act as a pathogen-associated molecular pattern (PAMP) recognized by the plant immune system . Seems not to induce necrosis, neither in several susceptible or resistant Vitis species nor in the dicot model plant Nicotiana benthamiana .
Sequence Mass (Da): 25079
Sequence Length: 223
Domain: The structure of NLP effectors is remarkably conserved with a high level of conservation of a central region containing the conserved undecapeptide motif AIMYAWYFPKD and heptapeptide motif GHRHDWE.
Subcellular Location: Secreted
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P59044 | MDQPEAPCSSTGPRLAVARELLLAALEELSQEQLKRFRHKLRDVGPDGRSIPWGRLERADAVDLAEQLAQFYGPEPALEVARKTLKRADARDVAAQLQERRLQRLGLGSGTLLSVSEYKKKYREHVLQLHARVKERNARSVKITKRFTKLLIAPESAAPEEAMGPAEEPEPGRARRSDTHTFNRLFRRDEEGRRPLTVVLQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLILDQCPDRGAPVPQMLAQPQRLLFILDGADELPALGGPEAAPCTDPFEAASGARVLGGLLSKALLPTALLLVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKYFRDERRAERAYRFVKENETLFALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVADGPRLQGDLRNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETEVTYQFIDQSFQEFLAALSYLLEDGGVPRTAAGGVGTLLRGDAQPHSHLVLTTRFLFGLLSAERMRDIERHFGCMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEEEEEGEEPNYPLELLYCLYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCPAGQALRLISCRLVAAQEKKKKSLGKRLQASLGGGSSSQGTTKQLPASLLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGLAWPQCRVQTVRVQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVITHPALDGHPQPPKELISTF | Function: Acts as the sensor component of the NLRP6 inflammasome, which mediates inflammasome activation in response to various pathogen-associated signals, leading to maturation and secretion of IL1B and IL18 . Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation . Acts as a recognition receptor (PRR): recognizes and binds specific pathogens and other damage-associated signals, such as lipoteichoic acid (LTA), a cell-wall component of Gram-positive bacteria, or double stranded RNA (dsRNA) . May also recognize and bind lipopolysaccharide (LPS), a major component of the outer membrane of Gram-negative bacteria; however, LPS is probably not a major activator of the NLRP6 inflammasome . Following LTA- or dsRNA-binding, NLRP6 undergoes liquid-liquid phase separation (LLPS), enhancing multivalent interactions, an essential step for the formation of the NLRP6 inflammasome polymeric complex . The NLRP6 inflammasome acts by promoting recruitment of effector pro-inflammatory caspases (CASP1 and/or CASP4) that catalyze maturation and secretion of IL1B and IL18 in the extracellular milieu . The NLRP6 inflammasome plays a central role in the maintenance of epithelial integrity and host defense against microbial infections in the intestine . Required to restrict infection against Gram-positive bacteria by recognizing lipoteichoic acid (LTA), leading to recruitment of CASP4 and CASP1, and subsequent maturation and secretion of IL1B and IL18 . Involved in intestinal antiviral innate immunity together with DHX15: recognizes and binds viral dsRNA to restrict infection by enteric viruses through the interferon pathway and GSDMD-dependent release of IL18 . Required to prevent infection by the apicomplexan parasite Cryptosporidium in enterocytes by promoting GSDMD-dependent release of IL18 (By similarity). The NLRP6 inflammasome may also regulate the gut microbiota composition by acting as a sensor of microbiota-associated metabolites to form a PYCARD/ASC-dependent inflammasome for downstream IL18 release and secretion of antimicrobial peptides (By similarity). Essential for gut mucosal self-renewal and proliferation (By similarity). Regulate mucus secretion in an inflammasome- and autophagy-dependent manner to prevent invasion by enteric bacteria, (By similarity). During systemic bacterial infections, the NLRP6 inflammasome negatively regulates neutrophil recruitment and neutrophil extracellular traps (NETs) formation (By similarity). May promote peripheral nerve recovery following injury via an inflammasome-independent mechanism (By similarity).
PTM: Polyubiquitinated with 'Lys-63'-linked chains, promoting the interaction with PYCARD/ASC and formation of the NLRP6 inflammasome. Deubiquitination by CYLD decreases the interaction with PYCARD/ASC.
Sequence Mass (Da): 98768
Sequence Length: 892
Domain: The poly-Lys disordered region (352-356) mediates the formation of liquid-liquid phase separation (LLPS), an essential step for nucleation and formation of the NLRP6 inflammasome complex.
Subcellular Location: Cytoplasm
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Q91WS2 | MDAAGASCSSVDAVARELLMATLEELSQEQLKRFRHKLRDAPLDGRSIPWGRLERSDAVDLVDKLIEFYEPVPAVEMTRQVLKRSDIRDVASRLKQQQLQKLGPTSVLLSVSAFKKKYREHVLRQHAKVKERNARSVKINKRFTKLLIAPGTGAVEDELLGPLGEPEPERARRSDTHTFNRLFRGNDEESSQPLTVVLQGPAGIGKTMAAKKILYDWAAGKLYHSQVDFAFFMPCGELLERPGKRSLADLVLDQCPDRAWPVKRILAQPNRLLFILDGADELPTLPSSEATPCKDPLEATSGLRVLSGLLSQELLPGARLLVTTRHAATGRLQGRLCSPQCAEIRGFSDKDKKKYFFKFFRDERKAERAYRFVKENETLFALCFVPFVCWIVCTVLQQQLELGRDLSRTSKTTTSVYLLFITSMLKSAGTNGPRVQGELRTLCRLAREGILDHHKAQFSEEDLEKLKLRGSQVQTIFLNKKEIPGVLKTEVTYQFIDQSFQEFLAALSYLLEAERTPGTPAGGVQKLLNSDAELRGHLALTTRFLFGLLNTEGLRDIGNHFGCVVPDHVKKDTLRWVQGQSHPKGPPVGAKKTAELEDIEDAEEEEEEEEDLNFGLELLYCLYETQEEDFVRQALSSLPEIVLERVRLTRMDLEVLNYCVQCCPDGQALRLVSCGLVAAKEKKKKKKSLVKRLKGSQSTKKQPPVSLLRPLCETMTTPKCHLSVLILSHCRLPDAVCRDLSEALKVAPALRELGLLQSRLTNTGLRLLCEGLAWPKCQVKTLRMQLPDLQEVINYLVIVLQQSPVLTTLDLSGCQLPGVIVEPLCAALKHPKCSLKTLSLTSVELSENSLRDLQAVKTSKPDLSIIYSK | Function: Acts as the sensor component of the NLRP6 inflammasome, which mediates inflammasome activation in response to various pathogen-associated signals, leading to maturation and secretion of IL1B and IL18 . Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation . Acts as a recognition receptor (PRR): recognizes and binds specific pathogens and other damage-associated signals, such as lipoteichoic acid (LTA), a cell-wall component of Gram-positive bacteria, or double stranded RNA (dsRNA) . May also recognize and bind lipopolysaccharide (LPS), a major component of the outer membrane of Gram-negative bacteria; however, LPS is probably not a major activator of the NLRP6 inflammasome . Following LTA- or dsRNA-binding, NLRP6 undergoes liquid-liquid phase separation (LLPS), enhancing multivalent interactions, an essential step for the formation of the NLRP6 inflammasome polymeric complex . The NLRP6 inflammasome acts by promoting recruitment of effector pro-inflammatory caspases (CASP1 and/or CASP4) that catalyze maturation and secretion of IL1B and IL18 in the extracellular milieu . The NLRP6 inflammasome plays a central role in the maintenance of epithelial integrity and host defense against microbial infections in the intestine . Required to restrict infection against Gram-positive bacteria by recognizing lipoteichoic acid (LTA), leading to recruitment of CASP4 and CASP1, and subsequent maturation and secretion of IL1B and IL18 . Involved in intestinal antiviral innate immunity together with DHX15: recognizes and binds viral dsRNA to restrict infection by enteric viruses through the interferon pathway and GSDMD-dependent release of IL18 . Required to prevent infection by the apicomplexan parasite C.tyzzeri in enterocytes by promoting GSDMD-dependent release of IL18 . The NLRP6 inflammasome may also regulate the gut microbiota composition by acting as a sensor of microbiota-associated metabolites to form a PYCARD/ASC-dependent inflammasome for downstream IL18 release and secretion of antimicrobial peptides . Its role in the regulation of the gut microbiota composition is however subject to discussion . Essential for gut mucosal self-renewal and proliferation . Regulate mucus secretion in an inflammasome- and autophagy-dependent manner to prevent invasion by enteric bacteria . During systemic bacterial infections, the NLRP6 inflammasome negatively regulates neutrophil recruitment and neutrophil extracellular traps (NETs) formation . May promote peripheral nerve recovery following injury via an inflammasome-independent mechanism .
PTM: Polyubiquitinated with 'Lys-63'-linked chains, promoting the interaction with PYCARD/ASC and formation of the NLRP6 inflammasome . Deubiquitination by CYLD decreases the interaction with PYCARD/ASC .
Sequence Mass (Da): 97402
Sequence Length: 869
Domain: The poly-Lys disordered region (350-354) mediates the formation of liquid-liquid phase separation (LLPS), an essential step for nucleation and formation of the NLRP6 inflammasome complex.
Subcellular Location: Cytoplasm
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Q86UT6 | MRWGHHLPRASWGSGFRRALQRPDDRIPFLIHWSWPLQGERPFGPPRAFIRHHGSSVDSAPPPGRHGRLFPSASATEAIQRHRRNLAEWFSRLPREERQFGPTFALDTVHVDPVIRESTPDELLRPPAELALEHQPPQAGLPPLALSQLFNPDACGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGRLPAFELLIPFSCEDLSSLGPAPASLCQLVAQRYTPLKEVLPLMAAAGSHLLFVLHGLEHLNLDFRLAGTGLCSDPEEPQEPAAIIVNLLRKYMLPQASILVTTRPSAIGRIPSKYVGRYGEICGFSDTNLQKLYFQLRLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAAACFLPSYCWLVCATLHFLHAPTPAGQTLTSIYTSFLRLNFSGETLDSTDPSNLSLMAYAARTMGKLAYEGVSSRKTYFSEEDVCGCLEAGIRTEEEFQLLHIFRRDALRFFLAPCVEPGRAGTFVFTVPAMQEYLAALYIVLGLRKTTLQKVGKEVAELVGRVGEDVSLVLGIMAKLLPLRALPLLFNLIKVVPRVFGRMVGKSREAVAQAMVLEMFREEDYYNDDVLDQMGASILGVEGPRRHPDEPPEDEVFELFPMFMGGLLSAHNRAVLAQLGCPIKNLDALENAQAIKKKLGKLGRQVLPPSELLDHLFFHYEFQNQRFSAEVLSSLRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLRARKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQLDRNRQLQELNVAYNGAGDTAALALARAAREHPSLELLHLYFNELSSEGRQVLRDLGGAAEGGARVVVSLTEGTAVSEYWSVILSEVQRNLNSWDRARVQRHLELLLRDLEDSRGATLNPWRKAQLLRVEGEVRALLEQLGSSGS | Function: Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction . Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 . Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis . Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species . Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner (By similarity). In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases (By similarity).
Sequence Mass (Da): 107616
Sequence Length: 975
Domain: The LRRCT domain mediates homodimerization and LRRNT mediates trimerization of the dimers.
Subcellular Location: Mitochondrion outer membrane
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Q3TL44 | MRWGCHLPRTSWGSGLGRTPQLPDEHISFLIQWSWPFKGVHPLRPPRAFIRYHGNSADSAPPPGRHGQLFRSISATEAIQRHRRNLTEWFSRLPREERQFGPTFALDTVHVDPVIRESTPDELLRPSTELATGHQQTQAGLPPLALSQLFDPDSCGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGRLPAFELLIPFSCEDLSSLGSTPASLCQLVTQRYTPLKEVLPLMTAAGSRLLFVLHGLERLNLDFRLAGTGLCSDPEEPGPPAAIIVNLLRKYMLPEASILVTTRPSTISRIPSKYVGRYGEICGFSDTNLQKLYFQLRLNQPDCGYGAGGASVSVTPAQRDNLIQMLSRNLEGHHQIAAACFLPSYCWLVCATLHFLHAPTPAGQTLTSIYTSFLRLNFSGETLDSTHTSNLSLMSYAARTMGKLAYEGVSSRKTYFSEEDVRGCLEAGIKTEEEFQLLQIFRRDALRFFLAPCVEPGHLGTFVFTVPAMQEYLAALYIVLGLRKTALQRVGKEVVEFVGRVGEDVSLVLGIVAKLLPLRILPLLFNLLKVVPRVFGRMVSKSREAVAQAMVLEMFREEDYYNDDVLDQMGASILGVEGPRRHPDEPSEDEVFELFPMFMGGLLSAHNRAVLAQLGCPIKNLDALENAQAIKKKLGKLGRQVLPPSELLDHLFFHYEFQNQRFSAEVLGSLRQLNLAGVRMTPLKCTVVASVLGSGRHPLDEVNLASCQLDPAGLHTLMPVLLRARKLGLQLNNLGPEACRDLRDLLLHDQCQITTLRLSNNPLTAAGVGLLMDGLAGNTSVTHLSLLHTDLGDEGLELLAAQLDRNKQLQELNVAYNGAGDTVALALAKAAREHPSLELLHLYFNELSSEGRQVLRDLGGSGEGGARVVASLTEGTAVSEYWSVILSEVQRNVHSWDPLRVQRHLKLLLRDLEDSRGATLNPWRKAQLLRVEGEVKTLLEQLGGSGH | Function: Participates in antiviral signaling . Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (By similarity). Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (By similarity). Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (By similarity). Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (By similarity). Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner . In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases .
Sequence Mass (Da): 107831
Sequence Length: 975
Domain: The LRRCT domain mediates homodimerization and LRRNT mediates trimerization of the dimers.
Subcellular Location: Mitochondrion outer membrane
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O50258 | MKMCDMFQTADWKTEKHVPAIECDDAVAADAFFPVTVSLGKEIAHPNTTEHHIRWIRCYFKPEGDKFSYEVGSFEFTAHGECAKGPNEGPVYTNHTVTFQLKIKTPGVLVASSFCNIHGLWESSKAVALK | Cofactor: Binds 2 iron ions per subunit.
Function: Non-heme iron protein.
Catalytic Activity: 2 H(+) + 2 superoxide = H2O2 + O2
Sequence Mass (Da): 14523
Sequence Length: 130
EC: 1.15.1.1
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Q5U3U7 | MARGEGAEQFSSGLLPTAKSVTQNEIKMVKLPKQQERKRALTVWSKVCFAIGGAPYQITGTALGFFLQIFLLDVAQLNPLNASVILFVGRAWDAVTDPTVGFLVSRTPWTRHGRMMPWILVSTIPAVLCYFLIWVVPPIEQGKMMWYLLFYCLFQTLQTCFHVPYSALTMFISTEQRERDSATAYRMTVEVFGTVVGTAIQGQIVGMANTPCKNNTSPNNSSNDLIQSNNSHIPLKSNIFDERCAYMIASAVISLIYVVCAAVLFFGVREQDVQGELKAQKRVSFQKGLRLVMGHGPYVKLVLAFLFTSLAFMLLEGNFAVFIKYTLGFREDFQNILLVIMVSATVSIPMWQWFLCRFGKKTAVYIGITWAVPFMILVVSVNSSLIVSYIVSIAAGVSVGAAFLLPWSMLPDVVDDFKLQNPTSQGHEAIFYSFYVFFTKFASGVSLGVSTLALSFAGYETGVCVQSDSVNLTLKLLVSAAPVSLIALGLLIFMTYPIDEERREYNNKQLQLLLRNEEEEDEMEVLKPDITA | Function: Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid.
Catalytic Activity: a 1-acyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) = a 1-acyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 59266
Sequence Length: 532
Subcellular Location: Cell membrane
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Q8NA29 | MAKGEGAESGSAAGLLPTSILQSTERPAQVKKEPKKKKQQLSVCNKLCYALGGAPYQVTGCALGFFLQIYLLDVAQKDEEVVFCFSSFQVGPFSASIILFVGRAWDAITDPLVGLCISKSPWTCLGRLMPWIIFSTPLAVIAYFLIWFVPDFPHGQTYWYLLFYCLFETMVTCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIVGQADTPCFQDLNSSTVASQSANHTHGTTSHRETQKAYLLAAGVIVCIYIICAVILILGVREQREPYEAQQSEPIAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGNFVLFCTYTLGFRNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALMESNLIITYAVAVAAGISVAAAFLLPWSMLPDVIDDFHLKQPHFHGTEPIFFSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPERVKFTLNMLVTMAPIVLILLGLLLFKMYPIDEERRRQNKKALQALRDEASSSGCSETDSTELASIL | Function: Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function . Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain (By similarity). Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain . Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons (By similarity). Does not transport docosahexaenoic acid in unesterified fatty acid (By similarity). Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport (By similarity). Not required for central nervous system vascular morphogenesis (By similarity). Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation . In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion .
Catalytic Activity: a 1-acyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) = a 1-acyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 60170
Sequence Length: 543
Subcellular Location: Cell membrane
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Q9DA75 | MAKGEGAESGSAAGLLPTSILQASERPVQVKKEPKKKQQLSICNKLCYAVGGAPYQLTGCALGFFLQIYLLDVAKVEPLPASIILFVGRAWDAFTDPLVGFCISKSSWTRLGRLMPWIIFSTPLAIIAYFLIWFVPDFPSGTESSHGFLWYLLFYCLFETLVTCFHVPYSALTMFISTEQSERDSATAYRMTVEVLGTVIGTAIQGQIVGQAKAPCLQDQNGSVVVSEVANRTQSTASLKDTQNAYLLAAGIIASIYVLCAFILILGVREQRELYESQQAESMPFFQGLRLVMGHGPYVKLIAGFLFTSLAFMLVEGNFALFCTYTLDFRNEFQNLLLAIMLSATFTIPIWQWFLTRFGKKTAVYIGISSAVPFLILVALMERNLIVTYVVAVAAGVSVAAAFLLPWSMLPDVIDDFHLKHPHSPGTEPIFFSFYVFFTKFASGVSLGVSTLSLDFANYQRQGCSQPEQVKFTLKMLVTMAPIILILLGLLLFKLYPIDEEKRRQNKKALQALREEASSSGCSDTDSTELASIL | Function: Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function . Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain . Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain . Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons . Does not transport docosahexaenoic acid in unesterified fatty acid . Not required for central nervous system vascular morphogenesis .
PTM: N-glycosylated.
Location Topology: Multi-pass membrane protein
Catalytic Activity: a 1-acyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) = a 1-acyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)
Sequence Mass (Da): 58984
Sequence Length: 534
Subcellular Location: Cell membrane
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O61613 | MPNENAEDLSGQELKQKAKEVADASEAMLEKVVAGLNIQDTASTNAAGNEDAEQPDGAKNEASVSANASKQALLQAVSDAMASTRQMAKKFAFWSTQPVTKLDEQVTTNECIEPNKEISEIRALPYTLPGGFKWVTLDLNDANDLKELYTLLNENYVEDDDAMFRFDYQPEFLKWSLQPPGWKRDWHVGVRVEKSGKLVGFISAIPSKLKSYDKVLKVVDINFLCVHKKLRSKRVAPVLIREITRRVNLTGIFQAAYTAGVVLPTPVATCRYWHRSLNPKKLVDVRFSHLARNMTMQRTMKLYKLPDQPKTKGYRRITAKDMDKAHKLLEDYLKRFQLSPVFSKEEFRHWFTPKEGIIDCFVVADEKGNITDLTSYYCLPSSVMHHPVHKTVRAAYSFYNVSTKTPWLDLMNDALISARNVQMDVYNALDLMENKKYFAPLKFGAGDGNLQYYLYNWRCPSMQPEEIALILM | Function: Adds a myristoyl group (tetradecanoyl group) to the N-terminal glycine residue of certain cellular proteins (Probable). Such protein modification are critical for the developmental processes that involve cell shape changes and movement .
Catalytic Activity: N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein]
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 53833
Sequence Length: 472
Subcellular Location: Membrane
EC: 2.3.1.97
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Q8TFN1 | MSDSKDSKGKAPQKPNDAEQTPGGKLTPQAAEALLENNPSLKNELGGLDKDKALEALRKMDISELLTGLSLTGKNKKDMAAFKFWQTQPVPRFDEAASNAAGGPIKMIDPEKVSKEPDALIEGFEWTTLDLTNEEELRELWDLLTYHYVEDDNAMFRFRYSKSFLHWALMSPGWRKEWHVGVRATKSRKLVASISGVPTQIRVRGQKIKVTEINFLCIHKKLRSKRLAPVLIKEITRRCYLNGIYQAIYTAGVVLPTPVSSCRYYHRPLDWLKLYEVGFSPLPRGSTKARQITKNHLPSHTSTPNLRPMEAKDVDAVHDLLERYLNQFDIHQAFTREEIDHWLVYKESPQKEQVIWSYVVEDPETHKITDFFSFYNLESTVIQHPKHDCVRAAYLYYYATETAFLDDQKALKNRLQMLMNDALILAKKAQFDVFNALTSHHNPLFLEQLKFGAGDGQLHFYLYNYRTAPIAGGVNEKNLPDENRMGGVGVVML | Function: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
Catalytic Activity: N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein]
Sequence Mass (Da): 56419
Sequence Length: 493
Subcellular Location: Cytoplasm
EC: 2.3.1.97
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Q4I061 | MSEESKPVEPVVDETNAELKGKAIAQADPEADEHAESASEEEHEEEHAAEGSSDKKKKKKKKSKRSKVKEALTGSKSAPTDADFHKALDGLTPKEVKEFLALNPALAQEVSKASNSDNPSADQASDMLKKMSLQDIMTGLAAGGKNAKDMGSYKFWQTQPVPKFGEDNNLQEGPLRIQKVEEVDKEPSALIPGFEWVTMDLTKEEEIKEVYELLNKHYVEDDEAMFRFNYSPTILRWAMMPPGWKKEYHVGVRASQSGLLCAFISAIPVHLRVRDNVVTCSEVNFLAIHKKLRGKRLTPVLIKEITRRSNLDGIWQGLYTAGVVLPKPVSTCRYFHRAINWQKLYECGFSPLPANSKPQYQIRKYALPDDTAIKGLRPLQEKDIEAVMDLYHRYNKRFDMTPKMSREEALHWFLPKTGPGEQQAVWTYVVEDENNKITDFFSFFCIESTAIGNSKHNVIKVAYMFYYGTEVGLQDKFDKAALKKRLNDLVHDALIISKRYKFDVFNALTLMDNALFLEQQKFGAGDGQLHYYLFNYRVNPIAGGVDRKNQLDEENLSGIGLVMP | Function: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
Catalytic Activity: N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein]
Sequence Mass (Da): 63944
Sequence Length: 564
Subcellular Location: Cytoplasm
EC: 2.3.1.97
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Q5UR64 | MSNLNLFETNQNKSISIMTQDITKLLDPLTEKFDGFSIKTLNVKHVDEIHELLNKHYIEDNDHIIRIIYSRDFLYWYLKYVPNNFTIGLMYKNKLVGLITALFVDMIMYDNKIKIPYINFFCIQNKIRKFGLSNILIEELKSRLLKIGVAYSLFTRMNCQNSLDKHFTSTIDFAIPINCPKLKSVGFIPDDEKLMNWKIENNPLSLMVKTDILSVTSKLNVHLQHLSVRPYLTEDSVHHFILPKKNIVYTFVKRDSRGYVTDMVSVYKHYAYILETGKIISNAQLSFYYNETMDLTQLILLLLDKLINYGFDQLIFRNFYDNGKINITRFETNGELNYYAGNISMPITCPNNMFMIPI | Function: Adds a myristoyl group to the N-terminal glycine residue of certain proteins.
Catalytic Activity: N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein]
Sequence Mass (Da): 41997
Sequence Length: 358
EC: 2.3.1.97
|
Q9YW20 | MNYWESKSICTVFTKYNDTEIINKIDPVKSNIDHSLYKQYTIGYMSNFNIVNICKFVNKHSNYIFDIDTFSWLVLNPFSDPSFNIVLYDNDKIVATIVGILRSIKIKNEIHKIIHTTFLTVDENYRKQGIHFYIIDKLMENAFNKGVLLGIFSTMKKIKKIKCVNVQDTYIIKSDSKKYKENNNVFDYKKLNQKNDDLYFIYNDMEIEYWFNKKYCHIISIYNNLFCFLKIKYKNNENLNILIEQYIHNKNINKYSIPNNSIMFSQYIQLPQIKLQNQIYTYIYNLNFNNLKCNICMF | Function: Adds a myristoyl group to the N-terminal glycine residue of certain proteins.
Catalytic Activity: N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein]
Sequence Mass (Da): 35805
Sequence Length: 298
EC: 2.3.1.97
|
Q7S3C8 | MPPTEESKPVDPAQEKQAAEALASLKEAQQPAADESGSEDEGADGTAQEAGSGSTKKKNKKKSKKKNKDKSASTESSAEVGLTEALAQADPKSALSGLTPKQIQEFIDLNPALANELLAASGSSGTTDVMEAFKKLKIQDIITGLASSGKNRKDMASYKFWATQPVPQFDEKPAIFEEGPLKIQKVEDIPDEPIPLNLAPFRWVTMDLTDEKQMQEVEKLLYGHFVEDDEAMFRFKYSTSILKWSLMSPGWRKEWHVGIRSGDTLCAFIAAVPTEIRVRDKVIQGSEVNFLCIHKKLRGKRLAPVLIKEITRRINREGIWQAIYTGGIVLPRPVSTCRYYHRALNWQKLYEVGFSPCPSNSKPAFQVRKYALPEQTSTKGLRELQVKDLDAVHSLLERYLKRFDLTPVFNREETEHWLLHKKDSYAEQVIYSYVVEDASGKITDFFSFYLLESTVIRHPKHNSIRAAYMFYYATETAFTEPFDKGALTKRLNDLMADALILAKRHNFDVFNALSLMDNALFLEKQKFGPGDGQLHYYLFNYKANPIHGGVDKKNRLDEDNLSGVGFVMV | Function: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
Catalytic Activity: N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein]
Sequence Mass (Da): 64151
Sequence Length: 569
Subcellular Location: Cytoplasm
EC: 2.3.1.97
|
Q8ILW6 | MNDDKKDFVGRDLYQLIRNAKDKIKIDYKFWYTQPVPKINDEFDENVNEPFISDNKVEDVRKEEYKLPSGYAWCVCDITKENDRSDIYNLLTDNYVEDDDNVFRFNYSSEFLLWALSSPNYVKNWHIGVKYESTNKLVGFISAIPIDMCVNKNIIKMAEVNFLCVHKSLRSKRLAPVLIKEITRRINLESIWQAIYTAGVYLPKPISTARYFHRSINVKKLIEIGFSCLNTRLTMSRAIKLYRIDDTLNIKNLRLMKKKDIDGLQKLLNEHLKQYNLHAIFSKEDVAHWFTPIDQVIYTYVNEENGEIKDLISFYSLPSKVLGNNKYNILNAAFSFYNITTTTTFKNLIQDAICLAKRNNFDVFNALEVMDNYSVFQDLKFGEGDGSLKYYLYNWKCASCHPSKIGIVLL | Function: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins . Myristoylates adenylate kinase AK2 (By similarity). During the asexual blood stage, may myristoylate proteins such as ARO, CDPK1 and GAP45 . Probably by mediating protein myristoylation, plays a role in the assembly of the inner membrane complex during the early stages of schizogony and in the formation of rhoptries in the late stages and thus merozoite egress .
Catalytic Activity: N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein]
Sequence Mass (Da): 47970
Sequence Length: 410
Subcellular Location: Cytoplasm
EC: 2.3.1.97
|
O43010 | MDNENNKNTKNSQQDSSFSEGGIRELLDRLALRSLIEKEEAAAPPKTYEDFKFWKTQPVPKFDDECTQEGPIDPNTDINQVPREPYRLLKEFEWATIDVTNDNELSEVHELLTENYVEDATAMLRFAYISEFLRWALMPPGYVKEWHVGVRVKSSRKLVAFISAVPLSIRVRDKIIKKCAEVNFLCIHKKLRSKRLTPLLIKEVTRRCHLENVWQAVYTAGVLLPSPVSLSRYMHRSLNWKKLYDIGFAPFPLGSTEKKETAKYHLPPNTQTPGLRPMELKDVPAVQSLLSQYMERFELAHLFSEEEVRHWFLYTDKVSSGPVVWSYVVENPESKKITDFFSFYSLPSTVIGNPKYKDIQAAYLYYYASDSCPKDLSSESQLAFVERCKLIVNDALILAKKFHFDVFNAVTVLDNNLFLKDLKFGEGDGFLNYYIYNYNCPKIPGGIDASKSVDYSRPSGMGFVMI | Function: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
Catalytic Activity: N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein]
Sequence Mass (Da): 53696
Sequence Length: 466
Subcellular Location: Cytoplasm
EC: 2.3.1.97
|
Q4PB56 | MSGIAGTSQDTSVAASASSSSTRPAAASSSIAPPSPSLTTAPVKEQEQDDDDDQENDDEEEEEEGTAAITGADGLTAKQRKKKKSKAAAKLRKKLGLGGSPTDASEGKLLASGSSREGKISDEVVSQVQRAVQAEHGSVAANAVTKANLAKVMAMMNLERDAMLKSQDSKQKAQKAIADHKFWKTQPVMKPTDAPVVKSDQEGSIEASVPPEQVRQEPYPLPADFEWVMIDVDNEGELKEVYDLLSANYVEDDDATFRFDYSPEFLHWVLKHPGYQKTWHIGVRVASTKKLVAFISGIPHELRVREKSYQSTEINFLCVHKKLRSKRLAPVLIKEVTRQCHLTGVFHAIYTVGSVLPTPVSCSRYYHRTINAKKLAEIGFSAIPHNMSMEAHVKRFELPAKTNLPGLREMERRDVAQVGKLMRRYMRRFDMAPRFSDHEVEHILLSGRGEACQGGRGRKGQVTWTYVVENSEGRITDMFAFYSLPSSILDSDKHQSLNAAYLFYYATDVVFQGDCDCDSDSSGVCDAETGRASTSQPSSERAVALAAGKAAWQCNSLTNLTSCELADEARVAAWDSEPAHIKTALKTRLNLLINTLLIIARDHDFDVVNCVTVMDNALFLQQQKFGPGDGFLRFYLFNWRTKPVAGGMGARPGEAELDPVQAYARSMAKRAAHTDDDDVKRLAEQLIRNAAINPAEVGSGNGIVMV | Function: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
Catalytic Activity: N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein]
Sequence Mass (Da): 77562
Sequence Length: 706
Subcellular Location: Cytoplasm
EC: 2.3.1.97
|
Q6C7G2 | MSADKFNEILKMFQQQMAMQDIPDREKAKKWEEYLFWKTQPVPKFDEDIDSEGPIEHKKLEDVRPTPYNLPAEYEWSDVDIENPEHIQEVYDLLYDNYVEDDDATFRFKYSASFLDWALKPPGWQKTWYPCVRVAATGKMVAFISAIPTSIQLRDNDLIKAVEINFLCVHKKLRSKRLAPVLIKEITRRVNQKDIWQALYTAGVVLPSPVSTCRYYHRPLNWTKLYEIGFSAIPPNQTAASMVARYTLPKEVPLKVRAMTKADVKAVHAILQNYLSAASEMSQHFSEEEVAHWFVDPISEDKNDDKIVYSYVVEEDGKVIDFFSFYKLDHTVLKEWATESNLRAAYGFYYATSSLSSAKARQDRVKELIGSAVILANNLGFEVYNELTLLDNPSHLDDLKFGCGDGYLNYYLFNYRAQPVHGGLDKQKQLEQLDGKGVGVIML | Function: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
Catalytic Activity: N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein]
Sequence Mass (Da): 51097
Sequence Length: 443
Subcellular Location: Cytoplasm
EC: 2.3.1.97
|
P14743 | MSEEDKAKKLENLLKLLQLNNDDTSKFTQEQKKAMKDHKFWRTQPVKDFDEKVVEEGPIDKPKTPEDISDKPLPLLSSFEWCSIDVDNKKQLEDVFVLLNENYVEDRDAGFRFNYTKEFFNWALKSPGWKKDWHIGVRVKETQKLVAFISAIPVTLGVRGKQVPSVEINFLCVHKQLRSKRLTPVLIKEITRRVNKCDIWHALYTAGIVLPAPVSTCRYTHRPLNWKKLYEVDFTGLPDGHTEEDMIAENALPAKTKTAGLRKLKKEDIDQVFELFKRYQSRFELIQIFTKEEFEHNFIGEESLPLDKQVIFSYVVEQPDGKITDFFSFYSLPFTILNNTKYKDLGIGYLYYYATDADFQFKDRFDPKATKALKTRLCELIYDACILAKNANMDVFNALTSQDNTLFLDDLKFGPGDGFLNFYLFNYRAKPITGGLNPDNSNDIKRRSNVGVVML | Function: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins. Substrate specificity requires an N-terminal glycine in the nascent polypeptide substrates. Uncharged amino acids are preferred at position 2 while neutral residues are favored at positions 3 and 4. Ser is present at position 5 in almost all known N-myristoyl proteins and Lys is commonly encountered at postion 6.
PTM: The N-terminus is blocked.
Catalytic Activity: N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein]
Sequence Mass (Da): 52838
Sequence Length: 455
Subcellular Location: Cytoplasm
EC: 2.3.1.97
|
Q9HB89 | MTPLCLNCSVLPGDLYPGGARNPMACNGSAARGHFDPEDLNLTDEALRLKYLGPQQTELFMPICATYLLIFVVGAVGNGLTCLVILRHKAMRTPTNYYLFSLAVSDLLVLLVGLPLELYEMWHNYPFLLGVGGCYFRTLLFEMVCLASVLNVTALSVERYVAVVHPLQARSMVTRAHVRRVLGAVWGLAMLCSLPNTSLHGIRQLHVPCRGPVPDSAVCMLVRPRALYNMVVQTTALLFFCLPMAIMSVLYLLIGLRLRRERLLLMQEAKGRGSAAARSRYTCRLQQHDRGRRQVTKMLFVLVVVFGICWAPFHADRVMWSVVSQWTDGLHLAFQHVHVISGIFFYLGSAANPVLYSLMSSRFRETFQEALCLGACCHRLRPRHSSHSLSRMTTGSTLCDVGSLGSWVHPLAGNDGPEAQQETDPS | Function: Receptor for the neuromedin-U and neuromedin-S neuropeptides.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 47351
Sequence Length: 426
Subcellular Location: Cell membrane
|
O55040 | MTPPCLNCSIFPGALSPNASRSPLVCNISEFKWPYQPEDLNLTDEALRLKYLGPQQMKQFVPICVTYLLIFVVGTLGNGLTCTVILRNKTMRTPTNFYLFSLAVSDMLVLLVGLPLELYEMQQNYPFQLGASACYFRILLLETVCLASVLNVTALSVERYVAVVRPLQAKSVMTRAHVRRMVGAIWVLATLFSLPNTSLHGLSQLTVPCRGPVPDSAICSLVGPMDFYKLVVLTTALLFFCLPMVTISVLYLLIGLRLRRERMLLQVEVKGRKTAATQETSHRRIQLQDRGRRQVTKMLFALVVVFGICWAPFHADRIMWSLVYGHSTEGLHLAYQCVHIASGIFFYLGSAANPVLYSLMSTRFRETFLQALGLGTQCCHRRQPYHGSHNHIRLTTGSTLCDVGHRNSRDEPLAVNEDPGCQQETDPS | Function: Receptor for the neuromedin-U and neuromedin-S neuropeptides.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 47934
Sequence Length: 428
Subcellular Location: Cell membrane
|
O17239 | MSQCTVEYNVSEITEYVLSTLGERCQSAGIVIPTVIIYGTIFLLGLFGNICTCIVIAANKSMHNPTNYYLFSLAVSDIIALILGLPMEFYQSLDYSYPYRFSEGICKARAFLIEFTSYASIMIICCFSFERWLAICHPLRSKIFSTLWRANVLIILAWTISFVCALPIAFIVQINKLPLPEDAKYQPWTNKVSTDGIFVLHTEFCAMNQSRPDQQKMIIIFAFTVFFVIPAIAIVIMYAHIAVQLESSEIDLKGDKMVKKRRNKSNRTVLKMLLSVVITFFICWLPFHIQRLLSVYTTWSETTTISPPVQFLSMIVFYISGFCYYSNSAANPILYNILSQKYRSAFCRTILGDHIANFVFKGHQRPGQSKRCSSSTEAEQRTLMTRGSVRVDKPHRKLEVHNY | Function: Putative G protein-coupled receptor for pyrokinin-like neuropeptide derived from the processing of the neuropeptide precursor capa-1.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 46073
Sequence Length: 403
Subcellular Location: Membrane
|
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