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stringlengths 6
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P23649 | MLLLFLNSVGFIVPVLLAVALLTLIERKMLGYMHVRKGPNNVGPYGLLQPIADGFKLLIKETLKPSNASPYLFYSSPALFLFLAILLWSIIPVGESTLNFNLSLVLILGLSSLSVYSLLGSGWSSNS | Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Catalytic Activity: a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 13813
Sequence Length: 127
Subcellular Location: Mitochondrion inner membrane
EC: 7.1.1.2
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P03887 | MFMINILMLIIPILLAVAFLTLVERKVLGYMQLRKGPNVVGPYGLLQPIADAIKLFIKEPLRPATSSASMFILAPIMALGLALTMWIPLPMPYPLINMNLGVLFMLAMSSLAVYSILWSGWASNSKYALIGALRAVAQTISYEVTLAIILLSVLLMSGSFTLSTLITTQEQMWLILPAWPLAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAAGPFALFFMAEYANIIMMNIFTAILFLGTSHNPHMPELYTINFTIKSLLLTMSFLWIRASYPRFRYDQLMHLLWKNFLPLTLALCMWHVSLPILTSGIPPQT | Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor . Essential for the catalytic activity of complex I . Essential for the assembly of complex I (By similarity).
Catalytic Activity: a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 35670
Sequence Length: 318
Subcellular Location: Mitochondrion inner membrane
EC: 7.1.1.2
|
Q8HEC4 | MILVLIMVILMMIFIVQSIAFITLYERHLLGSSQNRLGPTKVTFMGLAQALLDGVKLLKKEQMTPLNSSEVSFLLVPGISFIVMYLEWFTLPYFFDFISFEYSVLFFLCLIGFSVYTTLVSGIVSKSKYGMIGAIRASSQSISYEIAFSLYVLCIIIHNNVFNFMCKFNLSLLIVYIPFLIMIIAELNRAPFDFSEGESELVSGYNVEFASVAFVLLFLSEYGSLIFFSVLSSAMFFSFSILASFSIFSILIFIRSSYPRYRYDLMMSLFWFKLLPVSLIMLCFYAVVFYY | Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Catalytic Activity: a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 33377
Sequence Length: 291
Subcellular Location: Mitochondrion inner membrane
EC: 7.1.1.2
|
Q9B8D6 | MQYIELLIMFLSVLLAVAFLTVAERKTLGYMQRRVGPNAVGYYGILMAIADAAKLLLKEIVVPTHADKLILFVSPMISLISALLCWSVIPFAPGVTIYDSNYGFILTLAISSVGVFGTLLAGWSANSKYSLLGSIRSTAQLISYELVLTTIILLCILIGGTMNVSKYIEIQQAIWYGIPLLPLAIIFFIGCVAECARPPFDNVEAESELVSGHMTEYSSSIFVLFFLSEYASILFLSTLTAILFMGGGTGIILGLKANLFAFTYIWVRATLPRVRYDKLINLCWMIFLPILFGSAIAVPAYLYALDAIIILYRPGGL | Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Catalytic Activity: a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 34779
Sequence Length: 317
Subcellular Location: Mitochondrion inner membrane
EC: 7.1.1.2
|
O99824 | MILNFIYYFILILMVLLSIAFFTLMERKFLGYCHIRKGPNKTGAMGLLQPISDALKLFSKEMNKMFYMNKFIQIISPLIMILMMMMMWMIFYFSNNALNLNMSIIFFLCISSLASYAILFSGWSSNSKYSLIGSYRGFAQVISYEVSMAMILISLAIIPQSYNFISFLKIQETFPLIFSFLPIFIIWIITVLAELNRVPFDLAEGESELVSGFNIEYGSWLFAIIFMSEYGDIMMISFLTYYLFLGLKNLILFFVLILMTMIIMIRGTYVRMRYDQLMMMAWKMILPQSIIFLFLSYFIFLNINNFICINFCN | Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Catalytic Activity: a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 36722
Sequence Length: 313
Subcellular Location: Mitochondrion inner membrane
EC: 7.1.1.2
|
O47495 | MTPPSTGGEATPVLVLMVALGSILLVSASNWLSVYLAIELPTLSLFILVAQKRGSGFSAEAGLKYFVLGALASGLFLFGCALLCGLTGGTSIPCIDLVLNQGRGPALDPSGVITPIGSLLITGALLFKLSAAPFHMWAPDVYDGAPTTTTALLATVPKVGVFSILVSIGPVANVLLIATIFSMVVGALGALNQTKIKRLLAYSGIAHMGFVLWGIEIGTFESVQASLIYMILYVIMSVCAFAMVLALGGLKNLIVEFSGLSRKEPALAITLALTFLSIAGVPPLIGFFSKWWILLSGITYQYYLVSILAVICSVVAGVYYVRIVKIIYFQADSFFLVGLKTLREKKRINFRKSLLIGASFYLMGFMIISPNLLLQLAHWATVGLF | Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Catalytic Activity: a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 40974
Sequence Length: 385
Subcellular Location: Mitochondrion inner membrane
EC: 7.1.1.2
|
Q00229 | MVVCGETMKLVSLGVMLIGTILSVSSEELVGVWLGLELNLYGFLVIMNPDGHYSPEPCVKYFVVQSTGSILMLVGFVSLMEQHVVSGLVMSTAXTVLKSGVFPLHSWVPSVIKNSSWLASGLMLTWQKVAPLVFLSMILPSKSLWVVIVSMAGIGAVGGLNQNSVRVMSAYSSFVHTSWMLLGLTWSSVVFVGYFAVYSLSVGLFFYGCSLMNKMSMGSQLSSAASGMGLLMLMGMPPFLGFLAKVLVFLMSGSPVIVACIMGSVISLKFYIDFFYSMVMKSLVDKNKVEVKAIWSLVICMNIMGGALILVSFI | Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Catalytic Activity: a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 33912
Sequence Length: 314
Subcellular Location: Mitochondrion inner membrane
EC: 7.1.1.2
|
O21078 | MMTLILILGIFLGTMTTMFSSSWFFAWLGLEINMMAIIPMMLFPLSQRALESSMKYFISQAVASSTIILASSWNYFSSGQWTISFMSDNLAITLIILALLLKLGLAPLHFWLPEVLQGVNLHMGLIISTWQKLAPLTLLIQVSSNLNNMYILISISVMSVLAGGFGGLNQTQLRKLLAYSSISHMGWIVGVMAVSASLSWVTTVIYLIINFSIFTILIELNSTKISDLMLSWSKTSWSHTKCILVLLSLGGLPPFTGFFLKLSISNALISNSLILMTILLMAGSLISLFFYLRLSFMTALLLAPTNLQIKGTWKSPHYSNLLFNLMFLFSILLLPLSPFMISLFQISW | Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Catalytic Activity: a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 38789
Sequence Length: 348
Subcellular Location: Mitochondrion inner membrane
EC: 7.1.1.2
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Q8DJ02 | MVAIPRLRDTATVFVLSGYEYFLGFLIICSLVPVLALAASALLRPKSGRMIRLTTYESGMEPIGGAWIQFNVRYYMFALVFVIFDVETVFLYPWAVAFHQLGLLAFIEALIFIAILVVALVYAWRKRALEWS | Function: NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration (By similarity).
Catalytic Activity: a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 15003
Sequence Length: 132
Subcellular Location: Cellular thylakoid membrane
EC: 7.1.1.-
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Q85FH3 | MFEQGLILSAYLLCVGFFGLITSRNMVRALMSLELIFNAITLNFITLSNLFDNRETGEIFTLFVIAVAAAEAATGLAIALSIHRNRRSTRIDQSNLLKW | Function: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 11054
Sequence Length: 99
Subcellular Location: Plastid
EC: 7.1.1.-
|
P26289 | MILEHVLVLSAYLFLIGLYGLITSRNMVRALMCLELILNAVNMNFVTFSDFFDNSQLKGEIFCIFVIAIAAAEAAIGLAIVSSIYRNRKSIRINQSTLLNK | Function: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 11288
Sequence Length: 101
Subcellular Location: Plastid
EC: 7.1.1.-
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A9RAH1 | MIAMFTTLLMFYVSQNNIISLLIAIEILLLTVTVKIIYLGGQFDDVQSTMFALFIITLAGAESAIGLSLLVSYYRLRGKVTNIL | Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Catalytic Activity: a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 9307
Sequence Length: 84
Subcellular Location: Mitochondrion membrane
EC: 7.1.1.2
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P0C5X9 | MNLIDLILIAIYVIGISGLIFNKNNIINILIISELNLGTLGMLFVLASVELNDILGELSGLYILTFTAAESAIGLAIVVILYSKTGIINIRNLNKLKG | Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Catalytic Activity: a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 10544
Sequence Length: 98
Subcellular Location: Mitochondrion membrane
EC: 7.1.1.2
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P18934 | MIMILYWSLPMILFILGLFCFVSNRKHLLSMLLSLEFIVLMLFFMLFIYLNMLNYESYFSMMFLTFSVCEGALGLSILVSMIRTHGNDYFQSFSIM | Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Catalytic Activity: a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 11359
Sequence Length: 96
Subcellular Location: Mitochondrion membrane
EC: 7.1.1.2
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P07708 | MIMILYWSLPMILFILGLFCFVSNRKHLLSMLLSLEFIVLMLFFMLFIYLNMLNYENYFSMMFLTFSVCEGALGLSILVSMIRTHGNDYFQSFSIM | Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Catalytic Activity: a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 11386
Sequence Length: 96
Subcellular Location: Mitochondrion membrane
EC: 7.1.1.2
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P18939 | MLKIILPTIMLLPTALLSPAKSMWTNTTMYSLLIASISLHWLTPSYYPTKTLTLWTGMDQISTPLLVLSCWFLPLMIMASQGHLQHEPHKRKRMFISTLIIIQPFIILAFSATELMLFYISFEATLIPTLILITRWGNQPERLSAGIYLLFYTLISSLPLLVSILYLHTNTGTLHLPIIKLTHPNLPASWTSLLSSLALLMAFMVKAPLYGLHLWLPKAHVEAPIAGSMLLAALLLKLGGYGIMRVTLLMEPVSNFLHYPFLTLALWGALMTSSICLRQTDLKSLIAYSSVSHMGLVIAASMIQTQWSFSGAMILMISHGLTSSLLFCLANTNYERTHSRILILTRGLQPLLPLMSVWWLLANLTNMALPPTTNLMAELTIMVALFNWSSPTIILTGTATLLTASYTLYMLLSTQRGTLPSHITTTPNSNTREHLLMTLHIIPMLTLILKPELISGTPL | Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Catalytic Activity: a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 51146
Sequence Length: 459
Subcellular Location: Mitochondrion inner membrane
EC: 7.1.1.2
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P20113 | MFISVLLILFALCVTLIPEAHYHMVRVWSFVATIIPMWVVTWMWWNFDASGHGLQMLVILGRSHLAFGIDGVALSLMLLTTVLFPICMMLLRTVAGFMTFILLEVLVLSALCVLDLLGFYILFEASLILLFLLIGRAPYGSLEAAYKIVLYTMAGSLVLLPTLFMIYSECGTTNVLYMTCAYNHQTVLGWGLLAVLAVKIPLMPVHLWLPEAHVAAPTAGSVLLAGVLLKLGGIGFLRFMLPVVPEFCVSVFPLVSTLCLVSFLFSTLSTLRQIDLKKIVAYSSIAHMSMVTLAIFSQSEFSAYSSSFLMIAHGLISPALFLIVGILYDRAHTKFILYFSGLGASMPIGSTLFFLFTLGNLAFPLFPNFIAEVLCMVSIFAVHELLAYVFCVCQVLGAAYGFWAFNRVVHGLPRGPADVTRTEFHTVLPLLIGAVWLGIKPMA | Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Catalytic Activity: a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 48737
Sequence Length: 443
Subcellular Location: Mitochondrion membrane
EC: 7.1.1.2
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O21047 | MTIIAISIMNVVIGIAILGVILRKKIMPNQKFQRIFILGVQGILIVLSGIMLIGCEGTDIINRISPYINMVTVYSNNVNINIGYSIDGISAIFIFLTIILILSCNLISIRVIKEKTEQKFQIMLLLTEILIINFFAATDLVQLYIVYEATLIPMVIMIGVWGSRTEKKIAAFQILIYTLIGSIFMLMSIGILYSTLGTTDYIMIREYIDVLPENVRKLIFIGFFIGFAVKIPIAPLHLWLLRAHVEAPTAGSVLLAGILLKLGGYGYIRYNIGLFPDLCEYYFPIIGGICLISILYTGIATLTQLDVKRIVAYSSISHMNVIVLGLFSGVLQGIEGGIILMIGHGVVSGGLFLCIGVIYDRCKTRIVYAYNNLVHVMPIMAILFFLLVLGNIAFPITSNFVGELLIFIGLIKKNIIIAFFSALSMIVTAIYSFWLYNRIFFVNEIIKREANEVISSKGQIVADMNALFLIEDVMKKKEERGIDDIGQPKEVKKEQLIYSDVNIFEFTSISLMVIMMIIIGMKPSVVEGFIAINCLELISK | Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Catalytic Activity: a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 60234
Sequence Length: 540
Subcellular Location: Mitochondrion membrane
EC: 7.1.1.2
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P18931 | MLKIIFFLLFLIPFCFINNMYWMVQIMMFFISFIFLLMNNFMNYWSEISYFLGCDMLSYGLILLSLWICSLMLLASEMINKHNNYKNLFLLNIIILLLLLILTFSSMSLFMFYLFFESSLIPTLFLILGWGYQPERLQAGLYLLFYTLLVSLPMLIGIFYLMNKIGSMNFYLMNNFMFNYDLLYFCLLCAFLVKMPMFLVHLWLPKAHVEAPVSGSMILAGIMLKLGGYGMLRVISFLQLMNLKYSFVWISISLVGGVLVSLVCLRQTDLKALIAYSSVAHMGIVLSGLLTMTYWGLCGSYTLMIAHGLCSSGLFCLANVSYERLGSRSMLINKGLLNFMPSMTLWWFLLSSANMAAPPTLNLLGEIYLLNSIVSWSWISMILLSFLSFFSAAYTLYLYSFSQHGKLFSGVYSFSSGKIREYLLMLLHWLPLNLLILKSESFMLWL | Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Catalytic Activity: a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 51448
Sequence Length: 446
Subcellular Location: Mitochondrion membrane
EC: 7.1.1.2
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Q85CT7 | MNIINLPELNYEVFFVFIELGLIFGSLGVVFLTNIVYSAFLLGLVFVCISFLYLLLDADFVATAQILIYVGAVNILIVFAVMLINKPQSLQFLPSWTVGDTITLILCTSLFFLLISMILSISWSNIFSIAQSNKIGEQVLKSSVQGIGSSLLIDFLLPFELLSIVLLVALIGAITIARREKKVKLQKNRTLQVTKDSFIL | Function: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
Catalytic Activity: a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 22201
Sequence Length: 200
Subcellular Location: Plastid
EC: 7.1.1.-
|
Q95695 | MDLPGPIHDFLLVFLGSGLLVGGLGVVLLPNPIFSAFSLGFVLVCISLLYILSNSHFVAAAQLLIYVGAINVLIIFAVMFMNDSEYSTDFNLWTIGNGITSLVCTTILFLLMSTILDTSWYGVIWTTKLNQILEQDLISNSQQIGIHLSTDFFLPFELISIILLVALIGAISVARQ | Function: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
Catalytic Activity: a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 19214
Sequence Length: 176
Subcellular Location: Plastid
EC: 7.1.1.-
|
Q8M9T8 | MLEQSAQITLFVLDFFIFVGALGVVFFNNIIYSALFLGLTFLSVALLYLLLGSEFLSVAQVIIYVGAINVLIVFAIMLVNKPEFDKKDMIWVPIDLKSFCVNFILFSTIVTMIVTTPWKLLVNNIDVKLNSLNFLSPIAKIGYQFLSTLVLPFELLSLLLLIALIGAVIIARRELIEDT | Function: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
Catalytic Activity: a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 20041
Sequence Length: 179
Subcellular Location: Plastid
EC: 7.1.1.-
|
Q1ACE6 | MDFLNMSYQLIVAYLIQLGIYIGALAVIFFNNIVYAAISLALVLSLIALLYLFFDADFLAVTQILIYVGAINVLILFAIMLISLPKSSTFIFYFTKKSQISAFACISLFVLLVKIILQTPWSTQSSYILLNENNKLDQIGIYLLSNFLLPFELISLLLLIALIGAVSIARYQNTEETE | Function: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
Catalytic Activity: a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 19970
Sequence Length: 178
Subcellular Location: Plastid
EC: 7.1.1.-
|
Q19V56 | MILAEGVQKFSLFFLEGAVLVGALGVVLLPNILYSAFLLGGVLMSIAGIYLLLNADFVAAAQVLIYVGAINVLILFAIMLVNKNDGRVAAGTSNSSGVTNNIIGLTCIGLAGFLIDMIVTTPWLPKGVAVATSLSAKADSTAAQTQLKGSISIIGLHIFSDFLLPFEVISLLLLVTLVGAIVIARRERLSDLEISKISLLNLPDPSNGKTPSLK | Function: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
Catalytic Activity: a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 22364
Sequence Length: 214
Subcellular Location: Plastid
EC: 7.1.1.-
|
P10329 | MFFENSAILLCALLSIAVGYTKSPFMSLMYSVMLFINSSFVLMMLGFEFLALVNLLVYVGALAVLFLFVIMLLEIPATELRAYSRGWSTLGIFVFIINGVFQITPSMGPRGIITGLPGAESITNLGHALYLYFADLLILNSLVLTVALFGRFAIAPVRTTGR | Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Catalytic Activity: a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 17748
Sequence Length: 162
Subcellular Location: Mitochondrion membrane
EC: 7.1.1.2
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P48924 | MNIDIFLFYLFSIFALISSLMVIGLTNAVHSVLFLILVFCNVAGLLLLLGPEFFSFMLIIVYVGAIAVLFLFVVMMLNIKLKSTNISFSSLWPIGILTFVILLSQFFSSFYELDLVKFQGKELFFISWANENSNLTNIKVIGKVLYTHFNLLFLICGLILLVAMIGVIVLTMHQRVDVKKQQIALQLARTAPNVIKFIILRRKR | Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Catalytic Activity: a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 23206
Sequence Length: 204
Subcellular Location: Mitochondrion membrane
EC: 7.1.1.2
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P48925 | MIKLVLFYFFSGLSLVSASIVISVKNPVFSVVFLILVFFNVVGLLLLLGAEFLSLLFLIVYVGAIAVLFLFVVMILNLKFIELRSSFFYYAFFGSLIMAIFLFEIFIILNSDLTFASSYFLERKRIWVQELYSYTNLQILGNVLYTSYSYLFILSGFVLLVAILGAIILTLYQRSQIRRQDPNVQVVRNFDDTIRFFKFLK | Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Catalytic Activity: a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 23280
Sequence Length: 201
Subcellular Location: Mitochondrion membrane
EC: 7.1.1.2
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A9RAG2 | MNTISGMSSLTAIGMLTPVQSMTCLMILFVSTAMCLYSQGFVLMGMLYVTMYVGAMAMLFLFMLSLLKMEYTPQGTITPLMVTLLAMCLMPLDITYETYGMVTQMENVTDELVMVGNQLYTEYAMLLMLTGMMLMLSVMGAMSITK | Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Catalytic Activity: a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 16192
Sequence Length: 146
Subcellular Location: Mitochondrion membrane
EC: 7.1.1.2
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Q37314 | MSTLGLLIMLLGIIIMCTLVILRSVNPIYSILNLIVIYGCYASILLTVEMEFLACIYILVNVGAIAVLFLFIVMMININIVEIQETMKKYNIYMIVGIIGVVGLLGILITNYQIRIKEEVIADFSMFLINSEVVQLQATPSYLDFYSLFVETTDIRTMGSNVIYGSYSIWFIMACIILLIGMVGVIYITEDLIIEKRTLNERRRQDINSQVLREYKITIRNYRESK | Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Catalytic Activity: a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 25888
Sequence Length: 226
Subcellular Location: Mitochondrion membrane
EC: 7.1.1.2
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P18933 | MIQLMLYSLIITTSIIFLNMIHPLALGLTLLIQTIFVCLLTGLMTKSFWYSYILFLIFLGGMLVLFIYVTSLASNEMFNLSMKLTLFSSLILIFMLILSFIMDKTSSSLFLMNNDMQSIINMNSYFMENSLSLNKLYNFPTNFITILLMNYLLITLIVIVKITKLFKGPIRMMS | Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Catalytic Activity: a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 20075
Sequence Length: 174
Subcellular Location: Mitochondrion membrane
EC: 7.1.1.2
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A0A2A5JY22 | MRKSKVLTLGFQHVLAMYAGAVIVPLIVGSSLKLNAEQLAYLVSIDLLTCGIATLLQVWRNKFFGIGLPVMLGCTFTAVGPMIAIGSEYGMPAIYGSVLASGLFLALFAGFFGKLARFFPPIVTGSVVTIIGITLIPVAVQDMGGGQGSADFGSLSNLALSFGVLLFIILANRFFTGFIRAISILLGLIFGTIAGAFMGKVDIGPLLDASWFHGIHPFYFGFPTFHLPSILTMTLVAIVSVMESTGVFVALGKITEKELTADDLKRGYRSEGLASILGSIMNSFPYTTYSQNVGLIQISKVKSRDVVITAGFILVILGFMPKIAALTLLIPTAVLGGAMIAMFGMVVSSGIKMLGAIDLNNHENLLIIACSVSVGLGVTVAPNLFDHLPDSIKILTSNGIVAGSLTAILMNFLFTVGRKKQDESHASAENVHAA | Function: Uptake of the purines adenine and guanine, and the pyrimidine uracil. Transport is probably proton-dependent.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 45792
Sequence Length: 434
Subcellular Location: Cell membrane
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P15771 | MVKLAKTPKNQMKQKKMAPPPKKVEESEEEESSDLEESSGEEVMVPPKKQQKAAVTPAKKAATPAKKAATPAKKAVTPAKKAVATPAKKAVAPSPKKAAVVGKGAKNGKNAKKEESEEEDEDDEDDEEDEDEEEESDEEEEPAVPVKPAAKKSAAAVPAKKPAVVPAKQESEEEEEEDDEEEDEEDDESEDEAMDTTPAPVKKPTPAKATPAKAKAESEDEEDEEDEDEDEEDEDDEEEDEEESEDEKPVKEAPGKRKKEMANKSAPEAKKKKTETPASAFSLFVKNLTPTKDYEELRTAIKEFFGKKNLQVSEVRIGSSKRFGYVDFLSAEDMDKALQLNGKKLMGLEIKLEKAKSKESLKENKKERDARTLFVKNLPYRVTEDEMKNVFENALEVRLVLNKEGSSKGMAYIEFKTEAEAEKALEEKQGTEVDGRAMVIDYTGEKSQQESQKGGGERESKTLIVNNLSYAASEETLQELFKKATSIKMPQNNQGRPKGYAFVEFPTAEDAKEALNSCNNTEIEGRAIRLEFSSPSWQKGNMNARGGFNQQSKTLFVRGLSEDTTEETLRESFEGSISARIVTDRDTGSSKGFGFVDFSSPEDAKAAKEAMEDGEIDGNKVTLDFAKPKGEFQRGGGFGGGFGGRGGRGGRGGGRGGFGGRGGGRGFGGRGGGFRGGRGGGGDHKPQGKKIKFE | Function: Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly.
PTM: Highly phosphorylated during mitosis.
Sequence Mass (Da): 75640
Sequence Length: 694
Subcellular Location: Nucleus
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P19338 | MVKLAKAGKNQGDPKKMAPPPKEVEEDSEDEEMSEDEEDDSSGEEVVIPQKKGKKAAATSAKKVVVSPTKKVAVATPAKKAAVTPGKKAAATPAKKTVTPAKAVTTPGKKGATPGKALVATPGKKGAAIPAKGAKNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDEDDDDEDDEEEEEEEEEEPVKEAPGKRKKEMAKQKAAPEAKKQKVEGTEPTTAFNLFVGNLNFNKSAPELKTGISDVFAKNDLAVVDVRIGMTRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEKPKGKDSKKERDARTLLAKNLPYKVTQDELKEVFEDAAEIRLVSKDGKSKGIAYIEFKTEADAEKTFEEKQGTEIDGRSISLYYTGEKGQNQDYRGGKNSTWSGESKTLVLSNLSYSATEETLQEVFEKATFIKVPQNQNGKSKGYAFIEFASFEDAKEALNSCNKREIEGRAIRLELQGPRGSPNARSQPSKTLFVKGLSEDTTEETLKESFDGSVRARIVTDRETGSSKGFGFVDFNSEEDAKAAKEAMEDGEIDGNKVTLDWAKPKGEGGFGGRGGGRGGFGGRGGGRGGRGGFGGRGRGGFGGRGGFRGGRGGGGDHKPQGKKTKFE | Function: Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.
PTM: Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity).
Sequence Mass (Da): 76614
Sequence Length: 710
Subcellular Location: Nucleus
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P09405 | MVKLAKAGKTHGEAKKMAPPPKEVEEDSEDEEMSEDEDDSSGEEEVVIPQKKGKKATTTPAKKVVVSQTKKAAVPTPAKKAAVTPGKKAVATPAKKNITPAKVIPTPGKKGAAQAKALVPTPGKKGAATPAKGAKNGKNAKKEDSDEDEDEEDEDDSDEDEDDEEEDEFEPPIVKGVKPAKAAPAAPASEDEEDDEDEDDEEDDDEEEEDDSEEEVMEITTAKGKKTPAKVVPMKAKSVAEEEDDEEEDEDDEDEDDEEEDDEDDDEEEEEEEPVKAAPGKRKKEMTKQKEAPEAKKQKVEGSEPTTPFNLFIGNLNPNKSVNELKFAISELFAKNDLAVVDVRTGTNRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEKPKGRDSKKVRAARTLLAKNLSFNITEDELKEVFEDAMEIRLVSQDGKSKGIAYIEFKSEADAEKNLEEKQGAEIDGRSVSLYYTGEKGQRQERTGKTSTWSGESKTLVLSNLSYSATKETLEEVFEKATFIKVPQNPHGKPKGYAFIEFASFEDAKEALNSCNKMEIEGRTIRLELQGSNSRSQPSKTLFVKGLSEDTTEETLKESFEGSVRARIVTDRETGSSKGFGFVDFNSEEDAKAAKEAMEDGEIDGNKVTLDWAKPKGEGGFGGRGGGRGGFGGRGGGRGGRGGFGGRGRGGFGGRGGFRGGRGGGGDFKPQGKKTKFE | Function: Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats (By similarity).
PTM: Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group.
Sequence Mass (Da): 76723
Sequence Length: 707
Subcellular Location: Nucleus
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P13383 | MVKLAKAGKTHGESKKMAPPPKEVEEDSEDEEMSEDEDDSSGEEEVVIPQKKGKKATTTPAKKVVVSQTKKAAVPTPAKKAAVTPGKKAAATPAKKAVTPAKVVPTPGKKGAAQAKALVPTPGKKGAVTPAKGAKNGKNAKKEDSDEDEDEEDEDDSDEDEDEEDEFEPPVVKGVKPAKAAPAAPASEDEDEEDDDDEDDDDDDEEEEEEDDSEEEVMEITPAKGKKTPAKVVPVKAKSVAEEEEDDEDDEDEEEDEDEEDEEDDEDEDEEEEEEPVKAAPGKRKKEMTKQKEAPEAKKQKIEGSEPTTPFNLFIGNLNPNKSVAELKVAISELFAKNDLAAVDVRTGTNRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEKPKGRDSKKVRAARTLLAKNLSFNITEDELKEVFEDAVEIRLVSQDGRSKGIAYIEFKSEADAEKNLEEKQGAEIDGRSVSLYYTGEKGQRQERTGKNSTWSGESKTLVLSNLSYSATEETLQEVFEKATFIKVPQNPHGKSKGYAFIEFASFEDAKEALNSCNKMEIEGRTIRLELQGPRGSPNARSQPSKTLFVKGLSEDTTEETLKESFEGSVRARIVTDRETGSSKGFGFVDFNSEEDAKAAKEAMEDGEIDGNKVTLDWAKPKGEGGFGGRGGGRGGFGGRGGGRGGRGGFGGRGRGGFGGRGGFRGGRGGGGDFKPQGKKTKFE | Function: Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats (By similarity).
PTM: Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity).
Sequence Mass (Da): 77147
Sequence Length: 713
Subcellular Location: Nucleus
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P37994 | MLRNLVIFAVLGAGLTTLAAAGQDINNFTQAKAAAAKIHQDAPGTFYCGCKINWQGKKGTPDLASCGYQVRKDANRASRIEWEHVVPAWQFGHQRQCWQDGGRKNCTKDDVYRQIETDLHNLQPAIGEVNGDRGNFMYSQWNGGERQYGQCEMKIDFKSQLAEPPERARGAIARTYFYMRDRYNLNLSRQQTQLFDAWNKQYPATTWECTREKRIAAVQGNHNPYVQQACQP | Function: May protect the bacterium against the invasion of foreign DNA. It may have a random endonucleolytic activity. May be implicated as well in pathogenicity.
Sequence Mass (Da): 26456
Sequence Length: 232
Subcellular Location: Periplasm
EC: 3.1.21.-
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Q9HSL7 | MPRTLTDPTADRAAAFATDAAADGLTVSLIGSCVATLTGRSQRDLAAGVRTLLWKPDDTVVVHGASGRDPDAWASGGPVTVDAADGLTVACDGGHTAGALRVRFDAVHTATAFDAAGADATTVSGTEAALKDRVLDTPDLVEPGFQPLATERDTPAGPIDIYGRDADGTVTAVELKNVRAGPAAASQLQRYVAALRRTLHADATVRGILVAPAVTAKTRRLLADRGLTFSPVSPPGSRDR | Function: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
Sequence Mass (Da): 24602
Sequence Length: 240
Subcellular Location: Cytoplasm
EC: 3.1.-.-
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Q9HNR1 | MTVERVSAPTPAAFVDAANAAFRNGAVLSVQARCEVEYNGRTSGYLGDGDRLLVAKPDGTFLVHQPTGHKPVNWMPGGGTVEARTSQGDAVLLARRSNPTERVETRLHEVYGVTRFDAEDGATYEESGTEAEMHEYIEANPDALEAGLRIVEHERETKYGFIDFYAVDGDGTPVVIEVKRIQATLNHFDQLKRYVDRYAETNDDVRGMLVAPSASERVTRALRDNGLEFVALAEFGLDAKGATEAKLTDF | Function: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
Sequence Mass (Da): 27412
Sequence Length: 250
Subcellular Location: Cytoplasm
EC: 3.1.-.-
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Q9L9I5 | MDRIIEKLESGWWIVSHEQKLWLPYGELPHGLAANFDLVGQRALRIGEWQGEPVWLVLQHRRHDMGSVRQVIDQEAGLFQLAGRGVQLAEFYRSHKFCGYCGHPMHPSKTEWAMLCSHCRERYYPQIAPCIIVAIRREDSILLAQHVRHRNGVHTVLAGFVEVGETLEQAVAREVMEESGIKVKNLRYVTSQPWPFPQSLMTAFMAEYDSGEIVIDPKELLEANWYRYDDLPLLPPPGTVARRLIEDTVAMCRAEYD | Cofactor: Divalent metal cations. Mg(2+) or Mn(2+).
Function: mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some mRNAs and stabilizes RNA against 5'-processing. Has preference for mRNAs with a 5'-end purine. Catalyzes the hydrolysis of a broad range of dinucleotide pyrophosphates.
Catalytic Activity: a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)
Sequence Mass (Da): 29621
Sequence Length: 257
EC: 3.6.1.-
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Q87KQ7 | MLRKGDVNRVANAYWCVVAGSEIWLVDGAVPFGSAEQFSLPEENARQIGDYLGSPVMWINFADLEQDLPLVSLRDCLHFPEPLFMLLSKAIQYGHMTQSLRFCPQCGGRNFLNNNQFAMQCGECRTLHYPRIFPCIIVAVRKENQILLAQHPRHRNGMYTVIAGFLEAGETLEDCVAREVHEETGIHVKNIRYFGSQPWAFPSSMMMAFLADYDSGELNPDYTELSDAQWFGVKEMPPVAPTGTIARALIEQTISDILSD | Cofactor: Divalent metal cations. Mg(2+) or Mn(2+).
Function: mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some mRNAs and stabilizes RNA against 5'-processing. Has preference for mRNAs with a 5'-end purine. Catalyzes the hydrolysis of a broad range of dinucleotide pyrophosphates.
Catalytic Activity: a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)
Sequence Mass (Da): 29296
Sequence Length: 260
EC: 3.6.1.-
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P40010 | MRVRKRQSRRTSTKLKEGIKKKASAHRKKEKKMAKKDVTWRSRSKKDPGIPSNFPYKAKILEEIEAKKMKDLEERELAKQQRLEARKAAKEQGVDAMDEDMIEDDENGLAALVESAQQAAAEYEGTPSNDADVRDDELDVIDYNIDFYGEDVEGESELEKSRKAYDKIFKSVIDASDVILYVLDARDPESTRSRKVEEAVLQSQGKRLILILNKVDLIPPHVLEQWLNYLKSSFPTIPLRASSGAVNGTSFNRKLSQTTTASALLESLKTYSNNSNLKRSIVVGVIGYPNVGKSSVINALLARRGGQSKACPVGNEAGVTTSLREIKIDNKLKILDSPGICFPSENKKRSKVEHEAELALLNALPAKHIVDPYPAVLMLVKRLAKSDEMTESFKKLYEIPPIPANDADTFTKHFLIHVARKRGRLGKGGIPNLASAGLSVLNDWRDGKILGWVLPNTSAAASQQDKQNLSTINTGTKQAPIAANESTIVSEWSKEFDLDGLFSSLDKAIDASKDQDTMME | Function: GTPase required for 60S ribosomal subunit export to the cytoplasm.
Sequence Mass (Da): 57709
Sequence Length: 520
Domain: In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.
Subcellular Location: Nucleus
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Q9C923 | MVKKEKKANVSGKPKHSLDANRADGKKKTTETRSKSTVNRLKMYKTRPKRNAGGKILSNEYQSKELPNSRIAPDRRWFGNTRVVNQKELEYFREELQTKMSSNYNVILKERKLPMSLLTDNKKQSRVHLLDMEPFQDAFGRKTKRKRPKLVASDYEALVKKAAESQDAFEEKNGAGPSGEGGEEEDGFRDLVRHTMFEKGQSKRIWGELYKVIDSSDVIVQVIDARDPQGTRCHHLEKTLKEHHKHKHMILLLNKCDLVPAWATKGWLRVLSKEYPTLAFHASVNKSFGKGSLLSVLRQFARLKSDKQAISVGFVGYPNVGKSSVINTLRTKNVCKVAPIPGETKVWQYITLTKRIFLIDCPGVVYQSRDTETDIVLKGVVRVTNLEDASEHIGEVLRRVKKEHLQRAYKIKDWEDDHDFLLQLCKSSGKLLKGGEPDLMTGAKMILHDWQRGRIPFFVPPPKLDNVASESEVIVPGIDKEAIADNSQAAAALKAIAGIMSTQQQKDVPVQRDFYDEKDLKDDKKAKESTETDAENGTDAEEDEDAVSEDGVESDSDADEDAVSENDEEDESDSAE | Function: GTPase involved in pre-60S ribosomal subunit maturation.
Sequence Mass (Da): 65038
Sequence Length: 576
Domain: In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.
Subcellular Location: Nucleus
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P25710 | MAPQGDDTVFQPKDAIKSGVSGALFSGGAGLLMASLRTSMKKNNVGSMHVFTHGGGTIISFTLAGGIYRFAQQASANLREKEDGWNHAIGAFLGGSVMGLRSLRFPVILGFGAMAGSVVGAFAFSGGLTGWGRDPNVDEFERKEAMRLNRRRPVEETLAEVGEGRGIYPPGYQERRRQRLLEKYGVEVKPVSADPNVASA | Function: Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Catalytic Activity: a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 21349
Sequence Length: 200
Subcellular Location: Mitochondrion inner membrane
EC: 7.1.1.2
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Q9XTY6 | MSASQGNVFTRGLSRISRRKKKTKSIQNSLVSEQQPSFDAAIVPMPIPNDKSSIFSKGMDRLRRSLRLPKKRRDRSHDRHLSPDVTGGSKTEQWQPDEGAVRTGTCCFNVKYLGSVEVYESRGMQVCEGALKSLKASRRKPVKAVLYVSGDGLRVVDQGNSRGLLVDQTIEKVSFCAPDRQTDKGFAYICRDGASRRWMCHGFLATKETGERLSHAVGCAFSICLEKKKRRDEETAQVNVQSAQESTSSTPPKDIFHPNWEDNTSEGTSTQNPSNSRSNLAYQSFRKHVSIEDRYLDPQSVIINEVPASNHMDEIRRISKPRPTGNPALFLRQGSLRAPPDMPSSSDQFKRNMSLRTVSNNPTERSPEKKSFGTQLYNEPIYEGDEDPLGLGITPPVVTKTSGSLSNNGLDGINLNWKSIPAPVHQMQQHNANGDFVAAWPQNTIEKPTVGPLDKLQKQFEDIKLISISSGENTPTTRSKADEWLDDVLRVSMSMSPTSPSSDPPSTSSYSVLPKSGPPPAHAPPPLPVRQAVSNGSPSIYQQQLQQANSTRNSPAGINWNSSPNPMKISQPPAKPVDPFDVQWSRLAVNNTH | Function: Involved in the tethering and targeting of pkc-3 to modulate the intracellular distribution of the kinase. The complex formed with pkc-3 complexes are likely to be involved in assembly, maintenance, and/or regulation of protein complexes that execute asymmetric and/or polarized cell functions.
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 65510
Sequence Length: 593
Domain: The PID domain (phosphotyrosine interaction domain) of isoform a and isoform c is capable of binding residues 212-224 of pkc-3.
Subcellular Location: Cytoplasm
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Q8A0F5 | MEITKKPKIKSIPYDEFIDNESLEKLVKELNTGGANVFLGVLDDLVNWGRSNSLWPLTFATSCCGIEFMALGAARYDMARFGFEVARASPRQADMIMVCGTITNKMAPVLKRLYDQMPDPKYVVAVGGCAVSGGPFKKSYHVLNGVDKILPVDVYIPGCPPRPEAFYYGMMQLQRKVKIEKFFGGTNRKEKKPEFMK | Cofactor: Binds 1 [4Fe-4S] cluster.
Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 22077
Sequence Length: 197
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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A9II02 | MAIDGILKQGFITTSADKFLNWAKTGSMWPMTFGLACCAVEMMHAGAARYDLDQFGIIFRPSPRQSDLMIVAGTLCNKMAPALRKVYDQMPEPRWVVSMGSCANGGGYYHYSYSVVRGCDRIVPVDVYVPGCPPTAEALVYGLLQMQNKIRLTNTIAR | Cofactor: Binds 1 [4Fe-4S] cluster.
Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 17439
Sequence Length: 158
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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Q2RJU6 | MAVTRLKPADPQIPDNIILSTVDAMLNYCRAHSFWPVTFGLACCAIEMMAAGGARYDIARFGYEVFRPSPRQADLMIVAGTVTRKMAPLVRRLYEQMPAPKWVIAMGSCAISGGPFVDSYNVVPGVDTIVPVDVYVPGCAPRPEALINGLLALKKKVINPKVALVK | Cofactor: Binds 1 [4Fe-4S] cluster.
Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 18005
Sequence Length: 166
Subcellular Location: Cell membrane
EC: 7.1.1.-
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A0RMD1 | MLEKFSSKFNVLKHSTTNGLLSVQINPNDIYEAVLFVRDNIGFEILADIVCVDNLYIDKEKRFSLYYIFRKISSENLCIYIDIDINQSVKSVESIYKSANWGERECFDQFGVKFENHPNLKRILNHKDFQGYPLRKDYPITKYQVLYESDDLVGEMKNEMQRAGLASEENDEFKTKYTFLNIGPSHPATHGTIRNFVALDGEKIISCVTEIGYLHRGFEKACENHSYAQIIPYTDRLNYCSAMLNNVGYAKAVEEALGLNLPDRGIFMRVILGELARIIDHEVCLGAMFVDMGGLTNYWYLYNPRERIYNFLSKLTGARFTNSFARIGGMANDFYDGWKEELLAHLKDVEKGVDDTMILIEKNRIFLDRVQNICKINANDALSYGFSGPNLRASGVSFDLRKDKPYYYYDSFDFSVPVGSEGDIYDRMFVRFFEMRESISIIRQAIKLIPEGKISVDDKDVFLPSKDQVYSNIESLINHFKLIFDGIKLPNGHFYSASEGANGELGFFIFSNSEPNPYRVKLRPPCFYALNAFSSMVQGSLIADSILNLGSLNIIAGELDR | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 64196
Sequence Length: 561
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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Q3J1Q7 | MSLDQAIPEALQALRTRFGAAVRAEQATGEAFPVLWLDASVWEAAHRFLREEIAAPFPLLADLWAIDESLRQHRTGQPASRITLCSHLVSLVRNADLRLKLATDGRAPSIAGVYANADWYEREAHDMFGLDFGRETRRILMPPTWEGHPLLKTHYARATEKPPFVLTDRLFEAEERATITDPDLLGLPKLRDGEELMVLNFGPHHPSTHGVLRILLGLDGEEVVWAWPDIGYHHRGAEKMAERQTWHGFIPYCDRIDYLGGVISELPYLLAVERLCGIAVPPRAQMIRVMLCEFYRIMNHLLFYGTMAQDVGAMSPVFYMFTDREKGHEILNAITGARMHPAFFRIGGVAMDLPDGWDAMVRGFLDWMPARLDEYERMVLRSELFRARTVGVGAYDTDTALTWGTTGPGLRATGCDWDLRKLRPYSGYEQFDFEVPLGQRGDIFDRTRVRADEMRESLKIIRQCLENMPEGPVKADHPLTTPPPRGAMQKDIETLIAHFLQSSWGTVVPAGEATGQIEGHRGLTQYAIVSDGGTQSYRTRIRTPSFAHLQMIPKIVPGMTVADLVAHIASIDFVMSDVDR | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 65341
Sequence Length: 580
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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Q2NA62 | MAVVHSAPKYASNDGVRGTLVKALGDYVAASHEKYGEIIITVERDAIEDVLRTLRDDHDYQQLMEIAGVDYPERPERFEVVYMLLSLTKNHRVMVKVSTDEKTPVPTVTTLWPNAGWLEREVFDLYGVLFDGNTDLRRILTDYGFEGHPFRKDFPLTGYTELRYSEEEQRVVYEPVELAQDLRTFDFLSPWEGMTPPLPGDEKADMPPIDDPMVTEGPEDTGAGARANAKAAEGTPADPPAMDDEEEDDA | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 28113
Sequence Length: 250
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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B0TWP6 | MSARLQDHFNNVEKILNGFSVECYVAYGEINISIKDQRDIHLVLKKLKKEYHFKQLTDITAVDYLTYGQSDWQVGKVVSQTGFSRGRQQGFKTADVNNRFEIIYQLLSMANNVRVRVKCKLKDAQIIMVDSVEDLWPSANWAEREVYDMFGIYFNNHPDLRRVLTDYGFVGHPLRKDFPQTGYVEMRYDENLGKVVYEPVEIDDRVNAPRVIRNQ | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 25180
Sequence Length: 215
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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Q74GA6 | MAENNRAVIKLKEKFAASILDVREFRGEVTVTVAREKVVDICRFLKESLQYNLCTDVTAVDYLGKQEPRFMVVYNLYSIPNKDRLRLKAGVPDADCSIDTVSCVWNSANWLEREVYDLMGVQFNNHPDLRRILMTDDWVGHPLRKDYPLQGPDREPYKGRLS | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 18784
Sequence Length: 162
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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A9B4Z6 | MIDRATLEQRVSAQFPTVRIGDESGDLCLTVERQQLPALAGWLRDEPDLAFTFLNQLCGVDYLGRDPRFEVVVHLTSFQNKMRVTLHIEVPEADPTIPTLARLFPTANFQERETYDMFGIIFTGHPGLERILMPEDWLGHPQRKDHPLGYEEVAFTHNEDWIYANKPFAKE | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 19725
Sequence Length: 171
Subcellular Location: Cell membrane
EC: 7.1.1.-
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B3ES55 | MGKHIQYQGGNFKNTAPTKYQPTDLKVEEVLINIGPQHPATHGILRLEVILDGEIVVDVVPHLGYLHRCFEKHAATLPYNQTIPFVDRLDYLAAMNSEHAFAMGVEHMLGLTGKLPRRVEYIRVLMAELNRLASHFMAIGTYGIDLGAFTSFLWLMRDREYILRLFEWASGARMLYNYIWIGGLYYDLPVGFEERCLEFITYLKPKLEEINQLLIDNTLFIKRTANVGVLPLATAINHGVSGPILRASGLRLDLRRIDGYSIYPELSFDIPIGEGLMGHVGDCWDRTWVKFQECKESIKITEQCLVRLTSDLKRTADFNPQKMVPKKVRTKAQDCYIRAENPRGELGFFFRASDNGDKPIRCKARSSSFSNLSVISSIAKGQVLADLIAIIGSIDIVLGEIDR | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 45626
Sequence Length: 403
Subcellular Location: Cell membrane
EC: 7.1.1.-
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Q2GJY9 | MSDSSDGYAKPMTINFGPQHPAAHGVMRLILEMSGEVIERIDPHIGLLHRGTEKLIEYKTYLQALPYFDRLDYVSPMSQEHAYSLCVERLLGCEVPIRAKYLRVIFCELTRLLNHLLNVACQALDSGATTPLLWIFEEREKILSFYERASGARFHSAYIRPGGLAADVPDGLLDDIHEFTNYFPKLLDSVDDLLTENSIWKQRNVEIGKVTKQQALDWGFSGPMLRACGIPWDLRKSQPYEIYDILDFKVPVGSNGDCYDRYLVRMAEIRESLYILEQCLRDIPSGPVKTDDRKIAPPKREELKYSMEALIHHFKLFSEGYKVPEGEAYAAVEAPKGEFGVYIVSDGTNKPYRCRIRSPGFAHLQAIDAMARGHMLADLPVIIGSLDIVFGEIDR | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 44822
Sequence Length: 395
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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Q89KJ5 | MEFFESAFWTGFLWPLIIMVAESVLVLVVLLVAIAYILLADRKIWAAVQIRRGPNVVGPWGLLQSFADLLKFVLKEPIIPAGANKGVFLLAPLVSCVLALAAWAVIPTNLGWVISDINVGILFIFAISSLSIYGIIMAGWSSNSKYPFLAALRSAAQMVSYEVSIGFVIITVLLCAGTLNLSAVVEAQHVRGLASLIGLPQLTILNWYVWPLFPMFVVFYVSALAETNRPPFDLVEAESELVAGFMVEYGSTPYLLFMLGEYVAIVTMCAMATILFLGGWLPPVDLPPFNWVPGIIWFLLKVFFMFFLFAMAKAIVPRYRYDQLMRLGWKVFLPLSLAMVIVVAGVLHFAGIAPK | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 39194
Sequence Length: 355
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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C0Z769 | MMNTLLQQAPSWGTTLWFIIAAVLLLAVVLGFVTYAIYFERKVIGWMQLRIGPNRVGPLGLLQTVADVAKLLLKEDIRPQHADKALFTLAPILAYAPAFAVLAVMPFTDSIRFADLGIGLLYYIALSGITVLGVITAGWASNNKYSLIGGLRSAAQMISYEVPLVMSVVGIVLLTGSMNLKDIVEAQRDVWNIVPQFIGFAVFIIAAQAELNRTPFDLPEAESELVGGYHVEYSGFRFAMFMLAEYVYMFGMGALITILFFGGWLPIHPSLDFIPGIVWFILKFSVYVFLQFWIRATMPRLRVDQLMSFAWKVLLPVALFNILLTAVVVSYQNGMF | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 37413
Sequence Length: 336
Subcellular Location: Cell membrane
EC: 7.1.1.-
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P57258 | MIWLEENMIKITFCFFKVIFILLLIVFSSAMLSIVERRLLAVFQNRYGPNRVGWMGSLQLCADMIKILFKEDWIPPFSRKFIFVLSPVIAFTSLLCVIPIIPFTSHFVIIDLNIGILFFLMMASLSVYAILFAGWSSNNKYALLGAMRACVQTLSYEVFLGLSLMGVVAQSGSFKISDIVNSQKYIWNVFPQFFGFLTFLIAGLAVCHRHPFDQPESEQELADGYHIEYSGMKFGLFFIGEYISIITVSSLIVTLFFGGWLGPWIPSCIWFILKIIFFIFLFILIRAALPRPRYDQVLLFGWKFCLPLTLFNLFLTAFLILV | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 36972
Sequence Length: 322
Subcellular Location: Cell membrane
EC: 7.1.1.-
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Q87ZQ3 | MTWFTPDVIDAIIAVVKAIVVLLAVVVCGALLSFVERRLLGWWQDRYGPNRVGPFGMFQIAADMLKMFFKEDWTPPFADKVIFTLAPVVAMSALLIAFAVIPITPTWGVADLNIGLLFFFAMAGLSVYAVLFAGWSSNNKFALLGSLRASAQTVSYEVFMGLALMGIVVQVGSFNMRDIVEYQAQNLWFIIPQFFGFCTFFIAGVAVTHRHPFDQPEAEQELADGYHIEYAGMKWGMFFVGEYIGIILISALLVTLFFGGWHGPFDILPSLAFFWFALKTAFFIMLFILLRASIPRPRYDQVMDFSWKFCLPLTLINLLVTAAIVLLNTPAGSVQ | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 37443
Sequence Length: 335
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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A0RMD6 | MAIKTKTIRRKKIPFLQRIYLPFIFAGMARTFRHFFRNLKDSSNIDFLEYPEQKPTDITNRYRGLHRLTKNEKGDLKCVACDMCATACPANCIFITATEIEGSKEKAPSKFTIDLLECVFCGLCVEACPKDAIRMDTGIFTKVGNTRESFLADIKTLSQREEGSF | Cofactor: Binds 2 [4Fe-4S] clusters per subunit.
Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 18823
Sequence Length: 165
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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A6H1Q3 | MNNILVEIGIENYIYLCVVLFCIGIFGVLYRRNAIIMFMSIEIMLNAVNLLFVAFSTFHQDAQGQVFVFFSMAVAAAEVAVGLAILVSIYRNLSSIDIDNLKNLKG | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 11801
Sequence Length: 106
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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B0TWQ4 | MNSISVSVTNGLIFSTLLFVISVAGIIINRRNILILLMSIELMLLAVNTNFLIFANMHHQAMGGVFVFFIMAVAAAETAIGLAIVVAIFRKRKTIDLSKLNTLRG | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 11450
Sequence Length: 105
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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B9KIT6 | MCWRELLYMLPELYLLGSAMIALLLGIVVDARWVHRLSAVSMGVVVVLSWWSGVTDHVAEDVHLFNGLVLHTRYTCISRMLVGVAGFVASLLFLCARREVRYEFSVVMLFATLGAMTLVQAGHFLSLYISLELNSLSSCVLVCFNRSSERASESALKFFILSALSSCIMLYGISLVYGYSTGLECNVMQEILAGRASLGATLGCAFVLVGVLFKLAVVPFHMWAVDTYHGSPMAAMAFFLIVTKSAAILLLARIVGENGILQQSILYGIISVSGLSALVGELGALRQSNIKRLLAYSNIGQLGYVLPVVVLHGTSSYAIFHYVLTSWVINAWIFSVLLRYDDEGFELASLAGMHRSSPFVAFALVVSMVSAAGFPPFLGCWPKYFFLKSIVMSDIPTVVAFPYVLLVCAVGIVPCFYCFRIARVVYFDQPAMGAGHPALPHHLGLTVIAVVCMLLSVIALFLAQYFDILFQGLVWVFGGRT | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 52585
Sequence Length: 481
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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Q2GKQ9 | MYLSDFLYIVPEITVLGSALALLVLGMFTSERRVRSMSLISVAIAAVLACKELIYFSGEEVSLFGGFVVRTAHTCLARAVVAVSGLFAFLLFFFAKRSYRYEFAVLMLFAFLGTLTLVEAHHFLSFYLSFELIGFASYILVCFNRSSIKASEAAIKFFVLGALSSCIMLYGISLVYGYASEFSLGVVSKVLGGEESLGATFGCALVLVGLLFKLGAVPFHMWIPDTYEGAPTVAVVFFTIVTKTAMVLVFAGLMQGVVIPITGFVWSMLLMAALSMVVGEFSAMQQKNVKRLFAYANIGHIGYVLAGMSTGVVTFKPVLFYVVTYLLINVWIFTVLLRYDDEGFEITDVAGLAAKNPFLAFTFVAALLASAGLPPFSGFFAKYTLLKAIGGVDAFGVPTLVCVVFLCLTSIIPCFYCFRIAKVVYFDVPTGEHSATSRNVGLSIMAFVAVTLSLVVVLLRERII | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 50438
Sequence Length: 464
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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B6YQ48 | MDFSNFLCIEQELKLIALLVILFLYDTFCSKEWKKYFQNIAIVGFAIVIISEFPPYFTMYGEAFGGIHISSQLTFFMKSILNVATFLVFLQANKWLSSEKMLLRQGEFYVIMLISLLGMYFMISAENFVMLYIGMETASLPLACLVAFDKYQEKSAEAAVKYILTSALSSGVMLFGLSFLYGSLGSFYYSDIALNIVSSPLVKLGFVFFFGGLGFKLSLVPFHLWTADVYEGAPTSVTAYLSVVSKGAATFALIFVLYKVFGRIELIWNNILCWLLLATIVLGNLFAIRQQNIKRFFAFSSISQAGYILLGIIAGTAQGMTSTIFYTLVYLFSNLAAFGVIASVEYQTNGDTRIVSFNGLYRSNPGLAFVMMLAVFSLGGIPPFAGFFSKFFIFMAAAEQKQYILVFIALLNTVMSLYYYLLIVKAMFIEKRGEVVLEKIGIDNYNRISMVICTIGIFVIGFLSAIYEYIETISFGVLQK | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 53775
Sequence Length: 480
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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A1K5C1 | MNFVVPDFYPATAEIFVAVMALVIMLATTFARSVARGLAYGLTLVTLIGAAIITYNTANPRAVTTFSNMFIGDLLGDVLKLLIYFSMAVALLYGRSYLADRKLDKPEYYVLALLMTLGMMVMVTSNHLLSMYIGLELMSLSLYALVAFDRDSARGTEAAMKYFVLGALASGLLLYGMSMLYGATGTLEISGIAKSVYNQAANDTVLLFGLVFLMAGICFKLGVVPFHMWIPDVYHGANTAVTLIIATAPKLAAFAMAVRLLVWGLFDVAEHWQTMLMFVAVLSIVLGNLAAIAQTNLKRMLAYSGISHMGFMLLGLLSGVVDGDPHYALDAYSAAMFYAISYVIMSLASFGMIILLSRAGFEAENIDDFKGLNKRSPWFAAMMMFVMFSMAGIPFFIGFFAKLAVLQAVVAAGYIWVAVVAVLMSVIGAFYYLRLVKVMYFDEPADATPIQAPAELRVFLSANGLAIAAIGLAPQGVMTLCTFVLLASTQP | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 53128
Sequence Length: 491
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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Q81K10 | MDMNTLLSLSWHLMVPEFIILGAAILLSICDLFFKLNHRYVALGAIAAVVLAIVSLITLYSEPAGDILNGSFVLDGFSKGFKTLLLGGAALILCTAMSDDKKNPIEDKGEYYYLFLMALLGAMFMASSVDFVTLFVGLELLSLSSYILVGIRKKNRASNEAAMKYVINGGIGTAITLFGMSYLYGITGSTNIVDMQKVFAGELASGIQLLLALAFLLLLVGLSFKIATVPFHMWAPDVYEGAATPVTAFLGTISKMAGFLLIIRLFLMVFASVSVQGDMQSLYGRMSIYIAVLASITMIIGNVVALKQYNVKRLFAYSGIAHAGYLLVPLVALSPFTMDSMWFYMLAYMLMNIGAFAIIHGLILQSNKENITIFTGLYKRSPFTAIVMTIFILSLAGIPGTAGFIGKINIFLGALHVEPAHYVLASIMMGTTVISFVYYFRILQQMFFRTGEVEEKIRLPLNIKIVMSFCAISIVILGIVPMIGYNFFYEYFPLMKDFFFLGNVVQ | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 55596
Sequence Length: 506
Subcellular Location: Cell membrane
EC: 7.1.1.-
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Q64Y15 | MDYSQFLYMKEELSLIAVILILFVVDLLTCPDQKGATPKVNVRSLTLPAVILMTLHTVINLFPGTPAEAFGGMYQYTPMQTIIKAVLNVGTIIVLLMAHEWLKREDTRIKQGEFYVLTLSTLLGMYFMISAGHFLMFFIGLEMASIPMAALVAFDKYRHHSAEAGAKYILTALFSSALLLFGLSMIYGTSGTLYFNDLPGHITGNMLQIMAFVFFFAGMGFKISLVPFHLWTADVYEGAPTAVTSYLSVISKGSAAFVLMTILMKVFAPMVAQWQEVLFWVTIASITIANLFAIRQQNLKRFMAFSAISQAGYIMLGVIGGSEMGMTALVYYVLVYLAANLGVFAVISIVEQRSNKVEIDDYNGLYKTNPKLAFIMTLALFSLAGIPPFAGFFSKFFIFMAAFNSGFHLLVFIALINTVVSLYYYLLIVKAMYINPNEEPIPTFRSDNYTKVSLVLCTLGIIALGIASCIYQGIDKFSFGMGM | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 53523
Sequence Length: 483
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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Q1LTA1 | MKIITQILPLLIIGFTIILILLSIAWQRNHFMHASLTVVGLLLAIFSLFFVVHGSIANFTTLIHVDSFSIFYTGLVLIASLATSTLSYTWLSNNKDYKPDEFYILLLISTMGGILLTCAHHLTALFLGIELMSLPLLGMVGYTYRKKKVLEACIKYTIISSVASSFLLFGIALVYAVTGQLSFIGISNYALNEINYPLMLLAGLGMMIVGISFKLSLVPFHLWTPDIYQGAPTPVSTYLATVSKIAIFASLMRLFFYAPFNTHYEVKLLLCIIAICSMFIGNLMALSQNNLFRILGYSSTAHFGYLLVSWLVIQNVLVLETVGLYLFGYLLANLGVFGVISIMSNVSKKDTDLIGYYRGLFWYQPMLSVVMTVMMLSLAGIPMTLGFIGKFYIITLGINNNLKLLTILLLISTMISMLYYLRIVVSLYLYPAEKLHTNTYIQYNWALTSRGIMVLISSLLVLLLGLYPQPLINIVQWAQIINPR | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 54149
Sequence Length: 484
Subcellular Location: Cell membrane
EC: 7.1.1.-
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Q6MGN8 | MNINIGLSDVLLISPMIALFLASLLPITMKVLRGNREQHALITLGQALMGIVAAVVLLVVFGGSDKTAFNNGLIFDGVTQWMGIIALAGAGAAMVMMYENPSTTGKQFSELIFLAMSSAVGMLILVSAVDLLMVFIGLEMMSLALYLMIAMSHEEKLSKEAALKYFILGSFASAIFLYGVAFIFGSTGGTNILSFMDNAAELVQTSRLFLFGVTFVILGFCFKVSIAPFHAWTPDVYQGAPTPHTAFMATAVKTVSFAAFLRIIATKSLTGSDQLFDILQWMAVITMIVGNAAAIMQNNFKRMIAYSSVAHSGYLMVGLITAGVSDNGAFGASGVIFYLLAYGLMTIGAFAIAAMLEKSENHIVNIDDLAGFAKQRPMLALCLTVFLLSLAGIPPTLGFFGKFYMFNAAIGEGLLWLAIWGMLNSVIGVYYYLRPIVVMYMKEGNAEIAGHSLNATTVTAVVMALAIVLMGFVSGPIFSAVEKSLL | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 51977
Sequence Length: 486
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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B2IHV3 | MTPLPVVLAHALPELILAGGVLLLILIGAIRGKDSDGPMTELAVGLLGIAILTLVLGTKTQAVLFDGSFIDDAFGRFMKVLVLIGSLVSLIMGQTYLAREKIDKFEFPILILLSTLGMLMLISATGLIALYLGLELMSLALYVIAAFHRDDVKASEAGLKYFVLGALSSGMLLYGASLIYGFAGTVNFTGIATALHGETSLGVVFGLVFLTAGLAFKMSTVPFHMWTPDVYEGAPTPVTAFFASAPKLAAIAITMRIMITAFAGIKPQWQQIIVFISILSMALGSFAAIGQTNIKRLMAYSSIGHMGFALVGLAAGTETGIQGVLAYMAIYLVMTLGTFAAILSMRVNGVNVEQISDLAGLARTRGSMAFFLAIMMFSLAGIPPLAGFFAKWYVFNAAIQAHLYPLAVIGVLCSTVGAYYYLRIVKVMYFDDPAPAFDRPTPTLAAVLIVTGLAVLLLCVYPGSFVEATTVAARSLF | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 50570
Sequence Length: 477
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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C5C0R4 | MNFVQPVIQWASLAPILIVLGAAVLGVLIEAFAPRRVRRPVQVTLALLAAAGAFGAIAWRWAEVIGGGGGAPSTVVVGQLVEDGPALAAQGIIAILAFVGILVIAERGRRGAPGSEDAFAPQGASVPGSDYEDRARRAGLVQTEVYPLVLFSVGGMLVFPAAGDLLTLFIALEVLSLPLYLLSGLARRRRLLSQEASMKYFLLGAFSSALLLFGIALLYGYSGSVAIGEIHAATQATTGMDGLLVVGLVLLISGLLFKVGAVPFHAWTPDVYQGAPTPITGFMAACTKVAAFGALLRVVYVVAPAMTWDIQPFLWVVAVLTMVVGTVLAIVQTDMKRTLAYSSVAHAGFLLVGVVAMSPEGISSVFFYLLAYGLATIGAFALVALVRERDAEGNVTAEASHLAQWAGLGRRSPVVATVFALYLLSFAGIPLTSGFVGKFVAFAAAIDGGAWPLVVVGVLASAAAAFFYVRIIVLMFFTSPAEEAGAPSTTVVRSQGFTAVAVALTAAATLVLGVWPTPVLDLLAQATKFVV | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 55091
Sequence Length: 531
Subcellular Location: Cell membrane
EC: 7.1.1.-
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Q492I8 | MLITWTHIILLLPILIIGMTTVIVMLSIAYRRNLFLHTSLTIFGFSLAIISVGLVWDQRDRNFLQLICVDDFSILYIILVLVSGLSSSVLAYKWLLIYPSNNRDEFYLLLLISSIGGILLATTNHLVILFLGMELISLPLFGLIGYSFFNKFSLEASIKYIILSGVSSSFILFGIALIYAATGFLSFTSISQLLRLHIIASNQSIFMSTIGLGMMMVGFGFKLSLVPFHLWTPDVYQGAPSSISLYLTTSSKIAVISVLIRLLMVFPNQYNTVFCIFLLGIACCSALFGNLMAIKQDNIKRVLAYSSIAHTGYVLIGVIAILRVNHPMALETIGIYLISYVLTSIGAFGIINIVSFFYAHEDTDVDSLFVYRGLFWHQPMLSVLFTIIILSLAGIPMTLGFIGKFYLFVLGIDSKLWWFTIFIAMSSVISIFYYLRIIINLYLSPINRLNINSDFLSSWSVTPDKIIVIIVSFSILFLGLYPKPLIYFMHLIYPPVL | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 55788
Sequence Length: 497
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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Q2KUY6 | MMQSHIDFALATPEILLLVLALAVLLIDAVSSHPDRKTTYVLSLATLAILTVVSLFQWSNGVSGKTFNGMYVTDSFSHLLKITSYIAVAVTLIYGRVYAQSRDMLRGGELYVLTLLALLGQMVMISAGSLVSVYLGLELMSLALYALIALRRDDVVATEAAMKYFVLGALASGFLLYGMSMVYGSTGHLDLAEISRVIGSGQAKELPLVFGIVFLVAGLAFKLGAVPFHMWVPDVYQGSPTAVTLILGGAPKLAAFAMTLRLLVDGLHGLAADWQSMLMILAVLSLAIGNLTAIVQTNFKRMLAYSTISHMGFVLLGLASGVVVGKAEAASAAYGASLFYMITYVLTTLASFGIVLLLSRQGFECEQIDDLKGLNRRSPWHALIVLLLMFSLAGIPPLVGFYAKLAILQAVIESGHVALAVVAVLFSLIGAFYYLRVVKVVYFDEPVAEDAPLSATCVQRGLLSVNGALILILGILPGGLMALCVQVIKTSFAGL | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 52744
Sequence Length: 495
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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C0Z763 | MEVKDIFSYDWSYLLPEFIILGFATFLSLLDLFAGKRLGKQVIGWLSFLGTVIAAIFVIINMNALNKPYSYMIDMIRIDDYGNAFKLIFLAGTAFAILISLSYLKAGEVQHRGEYYYLLLTGLLGAMVMASSADLITLFVGLELLSLSSYVLVGLRKKSRLSNESAFKYVVSGSIATAVLLFGMSYVYGLAGTTHIYEISFRLAEAGMAGYQFLVYTAFAFLAVGLAFKISAAPNHMWAPDVYQGAPTPVTVFLAVVSKAAGFALIFRVMMISFFNVSDGTGSGRFFFEEGSLYLGLMAAASMIIGNTMALRQTNVKRMMAYSGIAQAGYLLVPFVPPTSLFFSEVIFYLFGYLLVSFGAFAVIMVVSREQETEDLKGFAGLYHRSPVMAIAMSIFLLSLAGIPITVGFFGKFYLFMGTLVVENYWLAAIMIITSVISYYYYFGIIRQMYMRPGTTEAPMVVPKGIWTFILIMAIATVFFGAFPGLVTDYIQIHFNPSFDFGNMLSPSSQ | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 56333
Sequence Length: 510
Subcellular Location: Cell membrane
EC: 7.1.1.-
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P57264 | MIINLQQLTALLPLLIIMLTVITVILSISYNRNHFFVAVFSILGLIFALCSLYFLIEIIPINVSILFHFNSNAILYIGMILISSICTCIFSYPWLLKYPFNKEEFYLLVIISTLGAISLTISHHMASFFINIELISLPMFGLIAYSRYQKYSLESSLKYIILSGVSSSFLLFGIAWVYSISGGLDFLSIHKSFNFASEKEILVVLFGISMILLSLFFKLSIVPFHLWTPDIYQGSPTSVLSFFSTAGKISVFSVLLNFLSYFSNSDNKVIYFILSLIIILSILVGNLMALFQKDIKRFLGYTSISQIGYLLIVLLVSHKNYSFSLEASAIYLCGYLFSNIACLGIVNLISTSHINNNASSINSYRGLFWSHPLLSSVLTLVLISSAGIPMTLGFIGKFYILSIVMIEHLWLIGFAFLIGSLLGLYCYLRIILNLYLHPSKLFKRDLNIPLNWVYTPSGIVICISGIILLALGIYPNPLIGLIKCTI | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 54481
Sequence Length: 486
Subcellular Location: Cell membrane
EC: 7.1.1.-
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Q89AT4 | MIITGQQLVALSPLLILMSIAIVVMLFIAYNRNRYIVFLLTSFGFLSVFISLFIVKKIVPIHATTLFHIDKYSLLYIGIVIISSFLACIFSHYCSLTNYLYNFEEFYLLLLFCTIGCVSIIISNNLCTFFIGSELISLSSIGLISYTFFEKKALEASIKYMVLSGIMSTLLLFGIALIYSVSGSLEFSSIIYELTMITKSFHNAIILFFGVSLFIIACSFKLSLFPFHIWTPDVYQGMSSEALMIFSTSVKIAIFSVLFKIFIVLSYFHIEEVFYYLVSIISCLSMIFGNIMAINQTSIKRLMGYSSISQLGYLFIVLVISRNMQFSLEVTGIYLINYALSNIGMFGIMSVLSSLYKNFNVDSIFSYRSLFWSSPILSGVMTVVMLSLSGIPMTVGFLGKFYLMSLVVKEHMWLFICLFIISTIIGFCAYLKIISCLFVAPSDSYCHKNIIISSQNINNKFLIGLLTTISIFVLFLGIFPQITIHLVKYFWIQW | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 56016
Sequence Length: 494
Subcellular Location: Cell membrane
EC: 7.1.1.-
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P24289 | WGALGHATVAYVAQHYVSPEAASWAQGILGSSSSSYLASIASWADEYRLTSAGKWSASLHFIDAEDNPPTNCNVDYERDCGSSGCSISAIANYTQRVSDSSLSSENHAEALRFLVHFIGDMTQPLHDEAYAVGGNKINVTFDGYHDNLHSDWDTYMPQKLIGGHALSDAESWAKTLVQNIESGNYTAQAIGWIKGDNISEPITTATRWASDANALVCTVVMPHGAAALQTGDLYPTYYDSVIDTIELQIAKGGYRLANWINEIHGSEIAK | Cofactor: Binds 3 divalent metal cations.
Function: Hydrolyzes only single-stranded DNA and RNA without apparent specificity for bases.
Catalytic Activity: Endonucleolytic cleavage to 5'-phosphomononucleotide and 5'-phosphooligonucleotide end-products.
Sequence Mass (Da): 29227
Sequence Length: 270
Subcellular Location: Secreted
EC: 3.1.30.1
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P32499 | MAKRVADAQIQRETYDSNESDDDVTPSTKVASSAVMNRRKIAMPKRRMAFKPFGSAKSDETKQASSFSFLNRADGTGEAQVDNSPTTESNSRLKALNLQFKAKVDDLVLGKPLADLRPLFTRYELYIKNILEAPVKSIENPTQTKGNDAKPAKVEDVQKSSDSSSEDEVKVEGPKFTIDAKPPISDSVFSFGPKKENRKKDESDSENDIEIKGPEFKFSGTVSSDVFKLNPSTDKNEKKTETNAKPFSFSSATSTTEQTKSKNPLSLTEATKTNVDNNSKAEASFTFGTKHAADSQNNKPSFVFGQAAAKPSLEKSSFTFGSTTIEKKNDENSTSNSKPEKSSDSNDSNPSFSFSIPSKNTPDASKPSFSFGVPNSSKNETSKPVFSFGAATPSAKEASQEDDNNNVEKPSSKPAFNLISNAGTEKEKESKKDSKPAFSFGISNGSESKDSDKPSLPSAVDGENDKKEATKPAFSFGINTNTTKTADTKAPTFTFGSSALADNKEDVKKPFSFGTSQPNNTPSFSFGKTTANLPANSSTSPAPSIPSTGFKFSLPFEQKGSQTTTNDSKEESTTEATGNESQDATKVDATPEESKPINLQNGEEDEVALFSQKAKLMTFNAETKSYDSRGVGEMKLLKKKDDPSKVRLLCRSDGMGNVLLNATVVDSFKYEPLAPGNDNLIKAPTVAADGKLVTYIVKFKQKEEGRSFTKAIEDAKKEMK | Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). As one of the FG repeat nucleoporins NUP2 is involved in interactions with and guidance of nuclear transport receptors such as SRP1-KAP95 (importin alpha and beta) through the NPC. Like the closely related NUP1 it also plays an important role in disassembling and recycling SRP1-KAP95 to the cytoplasm after nuclear import. Upon entry of the heterotrimeric SRP1-KAP95-cargo complex in the nucleus, NUP2 binds through its N-terminus to the SRP1 nuclear localization signal (NLS) binding site, thus accelerating the release of the NLS-cargo. SRP1 in turn is released from NUP2 by binding of the GSP1-GTP associated export factor CSE1. NUP2 may also have a chromatin boundary/insulator activity through indirect interaction with genomic DNA via CSE1 and blocking of heterochromatin spreading.
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 77881
Sequence Length: 720
Domain: Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG repeat types and their physico-chemical environment change across the NPC from the nucleoplasmic to the cytoplasmic side: FXFG repeats are especially abundant in NUPs on the nucleoplasmic side (in a highly charged environment and enriched in Ser and Thr).
Subcellular Location: Nucleus
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Q8NFH5 | MAAFAVEPQGPALGSEPMMLGSPTSPKPGVNAQFLPGFLMGDLPAPVTPQPRSISGPSVGVMEMRSPLLAGGSPPQPVVPAHKDKSGAPPVRSIYDDISSPGLGSTPLTSRRQPNISVMQSPLVGVTSTPGTGQSMFSPASIGQPRKTTLSPAQLDPFYTQGDSLTSEDHLDDSWVTVFGFPQASASYILLQFAQYGNILKHVMSNTGNWMHIRYQSKLQARKALSKDGRIFGESIMIGVKPCIDKSVMESSDRCALSSPSLAFTPPIKTLGTPTQPGSTPRISTMRPLATAYKASTSDYQVISDRQTPKKDESLVSKAMEYMFGW | Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC.
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 34774
Sequence Length: 326
Subcellular Location: Nucleus
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O13838 | MSFGGSGSITNRSTLKPLSVDDLRSPSPQKEYRGFRTSVSNIPQEKKFVPSHLSHFGSSQQRRFAPEVSSPLAEPYESSSSFRLSLSSPPSSKFGGPSFGTPKPFLHTNRLGTGSLIEDAPPTQSIYDFSSSRQINALNVGQSSSPFSPVSEKVYDPSFTMSGAPQDSNTSVIVFGFPPELTNQVIAEFSRFGTIISENSLTASSAGFTPSKGPISGNWLQLTYAEPSSAAKAVLSNGMLINDSFMVGCIYSPAEAKEHVPKTLRNSNKDLEMTDASSSETSMSIPVHADAHFQSQSGLGKKVIVQHKNDIFKSSQKHQPRNWLFHYLFGFGSTEPIDEEEKSKTASDNTSLQTSLFGKIVQVVLHTLFGF | Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm).
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 40255
Sequence Length: 371
Domain: Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG repeat types and their physico-chemical environment change across the NPC from the nucleoplasmic to the cytoplasmic side.
Subcellular Location: Nucleus
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Q5ZI22 | MTICQFFLQGRCRFGDRCWNEHPRGGGGRPHSAGPVRGAGGGWGAASQRYANVIQPPIFKHSTWGGSGDGGGFSGASDFGSPGNKSAVFSQNRFSALSSAHPADGFSDEEQRLLDCVAKDMATWESSGQWMFSCYSPEAGKPNVSGFREFSAEEVRLEYYNCSANNNTENYINSVNQLVQERRNRLQELKALNASGKESLLSQLKNAVTQPLPSLGFGGQQASSFGFPSFPVSSSSGAASFSFKANPSVPPGNAAAVGSSAAASNPPTFGVTSSPSVPNPVGSGNSSAPSAASFSFKTSGTTSGCGTSGLSGFGSSAAANSSSTAPLPVSATPSAATGTSQSGASSASAAQTAGASGHNVTSAPSAVPNGIASDKLYTPRSELTAEELEQFEAKRFTLGKIPLKPPPIDLLYL | Function: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm.
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 42317
Sequence Length: 413
Domain: The FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC.
Subcellular Location: Nucleus
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Q02854 | MSSTSSPTYTISKTLNTNYPLIDNDPHFRRVIGYARPSDYVHGTVAGAAGPGLLYLMEKMAPSGVGKGGFPKAMRLATAVGFFGGFLYFYQRSILRFYGMSENAREVQMDMREMVDKVKAGQPLYGVSTLPVDVQGMAARQSRYSALFFAVLPWFNFVNHNQHGVDTAKYYQQAERELEAERLGKGSSS | Function: Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
PTM: The N-terminus is blocked.
Location Topology: Single-pass membrane protein
Catalytic Activity: a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)
Sequence Mass (Da): 20977
Sequence Length: 189
Subcellular Location: Mitochondrion inner membrane
EC: 7.1.1.2
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P19968 | MASKVVTGVVKTTAGGVVPVSQKYTVQSVGVWERIRRAFAIDPNRSNGVPLVPYNRNPSPGSLDPLAYDDPVTIPAGDIADNPYWKRDARRNYPRLSVVGQAEAVALLSVGSASHPRVELVGENGSKQLVAAQEAGKTGGLAKYFEGTGVEAGKLVLAETGGLPPLPSGEKLGEGGKWDVYKYQLAEEPSYSEAYPCRSFS | Function: Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Catalytic Activity: a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)
Sequence Mass (Da): 21333
Sequence Length: 201
Subcellular Location: Mitochondrion inner membrane
EC: 7.1.1.2
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F7J186 | MISRIPRLLFENILVPVADVLTKSVSNFAGHKSDQSYNSNATRVSTISDEEIEFYLNLKSAVLLLCLALCIAGFSVLMYFLYVLVFVPYNRVKRLGSIGYQNHEEGHLSKKDIANLVRRRRKVGDDLPPVFPNGWFRLVDSQQLEPGQVKQVTALGEHFAVFRSKSGKASILDAYCPHMGGNLAVGGIVKNDCLECPFHGWRFDGDGKCVAIPYSEKIPTFAKTKSWPCREVNKAIFVWFHCDGKEPEWEIPDISEISTGKFTYKGRVEHHANTHIQDVPENGSDLAHLSHLHVPHAMSGANLSTQYSSWWNFAEHIFKAQCIGPADGEPHISLFYLTHYLHVFKRFKLLSLNLNVYQIGPGIVHLHFDSPFGKGVFVQTLTPVEPLHLVLTHNLHASWSIPVWLGRIFLYLEAIQVDRDVMIWNNKTFEPRPKLLKEDSLIAKYRRWYSQFYTENSPRLTLKSEDGNGW | Cofactor: Binds 1 [2Fe-2S] cluster per subunit.
Function: Catalyzes the production of 7-dehydrocholesterol (7-DHC or cholesta-5,7-dien-3beta-ol) by inserting a double bond (desaturating) at the C7-C8 single bond of cholesterol. Essential regulator of steroid biosynthesis as this reaction is the first step in the synthesis of the steroid hormone Delta(7)-dafachronic acid.
Catalytic Activity: cholesterol + H(+) + NADPH + O2 = 7-dehydrocholesterol + 2 H2O + NADP(+)
Location Topology: Single-pass membrane protein
Sequence Mass (Da): 53548
Sequence Length: 470
Pathway: Steroid hormone biosynthesis; dafachronic acid biosynthesis.
Subcellular Location: Membrane
EC: 1.14.19.21
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F7J187 | MLIEYLIRITVMVITSERLLILMGLCDESFHFPVMIRVVFNAAVAIVIALVMSKLYKVLFAPLDLRRKLEDVGYVHHDHSVSREENIRDTQRRKKLGNTPPVFPNGWFKVADSTWIKKGQVKSIYFFGEQLALFRNKRGLLRALDAYCPHLLANMAAGGKVVNSDCLECPFHGWKFSGETGKLVDVPYAQKVPTFVSVKKWSCCEVDGMAYLWYHCDGGEPKWVLPSSVTINTLKYAGKTEHIINSHIQDIPENAADISHLDHLHKPVIGSDVEKTNESLLNNLIFHSIQASWKPPTDPNEPHRSTMSIKDNIHLSIFNIKIPLLYLEFEIDQIGPGAVHIHVRTPFFRGLMLQNVTPIEPFVQKLTHSFYVSPWVPVCIAKAFYLLETTQIERDILMWNNKTYFRQPVLVKEESALAKHRRWYQQFYSENSPRMNHRGDLVYPGKPKLADW | Cofactor: Binds 1 [2Fe-2S] cluster per subunit.
Function: Catalyzes the production of 7-dehydrocholesterol (7-DHC or cholesta-5,7-dien-3beta-ol) by inserting a double bond (desaturating) at the C7-C8 single bond of cholesterol. Essential regulator of steroid biosynthesis as this reaction is the first step in the synthesis of the steroid hormone Delta(7)-dafachronic acid.
Catalytic Activity: cholesterol + H(+) + NADPH + O2 = 7-dehydrocholesterol + 2 H2O + NADP(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 51977
Sequence Length: 452
Pathway: Steroid hormone biosynthesis; dafachronic acid biosynthesis.
Subcellular Location: Membrane
EC: 1.14.19.21
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Q1JUZ2 | MADRQHFPSAITEAVSSNTACPDTGPKAETTNIFLLLQRNITIESSKHVFSSIVEYILILTLMFAFSAILYVIYKSYISPVFYKKELTEVGFDHIPQGPDKGRRISRAQASRRMGSKLPPPYPNGWFAVAETRELKVGSVLSIDALGQNLCVYRGEDGLARCVDAYCPHLGANLAVGGTVRGSCIECPFHKWRFNAAGTCVSLPGSDIAPKGVSIRTWCVVETDGAIWIWHDAEGREPLWEITDPPELKDFGYRGRNEFEVSAHIQEIPENGADVPHLNAVHSSSLLSDLGERYPVLHEIIGRHVWNADWTKSDDHTSLMHITQEYKVLKYDLARIDVKVTQIGPGHVRLFLKTSVGPFYIAQSVTPLGPLLQKVIHRVYSPAYNAPVGAFLVRCEAYMFERDVTIWNSKRFVSAPAYVKTDKTIRTFRNWFGQFYSEHSLSFRDALQNPLDW | Cofactor: Binds 1 [2Fe-2S] cluster per subunit.
Function: Catalyzes the production of 7-dehydrocholesterol (7-DHC or cholesta-5,7-dien-3beta-ol) by inserting a double bond (desaturating) at the C7-C8 single bond of cholesterol. Essential regulator of steroid biosynthesis as this reaction is the first step in the synthesis of the steroid hormone Delta(7)-dafachronic acid.
Catalytic Activity: cholesterol + H(+) + NADPH + O2 = 7-dehydrocholesterol + 2 H2O + NADP(+)
Location Topology: Single-pass membrane protein
Sequence Mass (Da): 50950
Sequence Length: 453
Pathway: Steroid hormone biosynthesis; dafachronic acid biosynthesis.
Subcellular Location: Membrane
EC: 1.14.19.21
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Q6DHJ3 | MENTRASLMFKTLAVAAIGLSATFVMLVRDPSDTLFGGGYPELWRRTGLAGAPTRAAACIFAGVFLLAMGWLYRLLFAPLELLRGVDEVGYIAEDGRSRAQAANEVRRRRKTGELPPVYPNGWYRVLDSHMLERGDVKSVTVLGQQVAVFRGQDGKAYVVDAYCPHLGANLAVGGRVVGGCIECPFHGWQFRGVDGRCVKIPYADKVPEFAKVRCWPSCEINGLVLVWFHCDGLEPSWRVPEQSQITRGEWVYRGRTEHFINAHIEEIPENAADIAHLAHLHTPGIVSGVDLRYTNSKTWEFIRHDWKVEWKPEPEPNKHCSQMLVKHALTVFGRHWPLLDLDVLARQVGPGVVFLLFEHSFLGRGVIMHCVTPVEPLLQCVSHTIFYQSSIPPLVPKFILRAECIQFERDVMIWNNKTYISKPMLVKEDSAIQKHRRWFSQFYSENSPRLRYQHDTLDF | Cofactor: Binds 1 [2Fe-2S] cluster per subunit.
Function: Catalyzes the production of 7-dehydrocholesterol (7-DHC or cholesta-5,7-dien-3beta-ol) by inserting a double bond (desaturating) at the C7-C8 single bond of cholesterol. This reaction is the first step in the synthesis of the steroid hormone Delta(7)-dafachronic acid.
Catalytic Activity: cholesterol + H(+) + NADPH + O2 = 7-dehydrocholesterol + 2 H2O + NADP(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 52307
Sequence Length: 460
Pathway: Steroid hormone biosynthesis; dafachronic acid biosynthesis.
Subcellular Location: Membrane
EC: 1.14.19.21
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Q8VEY3 | MEIKNCSVVTEFILLGIPHTEGFETLLFVLFLPFYACTLVGNVSILVAVISSTRLHTPMYFFLGNLSVFDMGFSSVTCPKMLFYLMGLSRLISYQDCVSQLFFFHFLGSIECFLYTVMAYDRFAAICHPLRYSVIMNSKICVALAVGTWLLGCFHSSVLTSLTFTLPYCGPNEVDHFFCDIPAILPLASADTSLAQRVSFTNVGLVSLVCFLLILLSYTRITISILSIQSTEGRQRAFSTCSAHLIAILCAYGPIITIYLQPTPNPMLGTVVQILMNLVGPMLNPLIYTLRNKEVKIALKKILHGKGSVSEG | Function: Potential odorant receptor.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 34528
Sequence Length: 312
Subcellular Location: Cell membrane
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Q8NGC3 | MGKTKNTSLDAVVTDFILLGLSHPPNLRSLLFLVFFIIYILTQLGNLLILLTMWADPKLCARPMYILLGVLSFLDMWLSSVTVPLLILDFTPSIKAIPFGGCVAQLYFFHFLGSTQCFLYTLMAYDRYLAICQPLRYPVLMNGRLCTVLVAGAWVAGSMHGSIQATLTFRLPYCGPNQVDYFICDIPAVLRLACADTTVNELVTFVDVGVVAASCFMLILLSYANIVNAILKIRTTDGRRRAFSTCGSHLIVVTVYYVPCIFIYLRAGSKDPLDGAAAVFYTVVTPLLNPLIYTLRNQEVKSALKRITAG | Function: Odorant receptor.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 34297
Sequence Length: 310
Subcellular Location: Cell membrane
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Q8NGC4 | MERINSTLLTAFILTGIPYPLRLRTLFFVFFFLIYILTQLGNLLILITVWADPRLHARPMYIFLGVLSVIDMSISSIIVPRLMMNFTLGVKPIPFGGCVAQLYFYHFLGSTQCFLYTLMAYDRYLAICQPLRYPVLMTAKLSALLVAGAWMAGSIHGALQAILTFRLPYCGPNQVDYFFCDIPAVLRLACADTTVNELVTFVDIGVVVASCFSLILLSYIQIIQAILRIHTADGRRRAFSTCGAHVTVVTVYYVPCAFIYLRPETNSPLDGAAALVPTAITPFLNPLIYTLRNQEVKLALKRMLRSPRTPSEV | Function: Odorant receptor.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 35055
Sequence Length: 313
Subcellular Location: Cell membrane
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Q8NGN3 | MSNASLVTAFILTGLPHAPGLDALLFGIFLVVYVLTVLGNLLILLVIRVDSHLHTPMYYFLTNLSFIDMWFSTVTVPKMLMTLVSPSGRAISFHSCVAQLYFFHFLGSTECFLYTVMSYDRYLAISYPLRYTSMMSGSRCALLATGTWLSGSLHSAVQTILTFHLPYCGPNQIQHYFCDAPPILKLACADTSANVMVIFVDIGIVASGCFVLIVLSYVSIVCSILRIRTSDGRRRAFQTCASHCIVVLCFFVPCVVIYLRPGSMDAMDGVVAIFYTVLTPLLNPVVYTLRNKEVKKAVLKLRDKVAHPQRK | Function: Odorant receptor.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 34569
Sequence Length: 311
Subcellular Location: Cell membrane
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Q8NH81 | MLEGVEHLLLLLLLTDVNSKELQSGNQTSVSHFILVGLHHPPQLGAPLFLAFLVIYLLTVSGNGLIILTVLVDIRLHRPMCLFLCHLSFLDMTISCAIVPKMLAGFLLGSRIISFGGCVIQLFSFHFLGCTECFLYTLMAYDRFLAICKPLHYATIMTHRVCNSLALGTWLGGTIHSLFQTSFVFRLPFCGPNRVDYIFCDIPAMLRLACADTAINELVTFADIGFLALTCFMLILTSYGYIVAAILRIPSADGRRNAFSTCAAHLTVVIVYYVPCTFIYLRPCSQEPLDGVVAVFYTVITPLLNSIIYTLCNKEMKAALQRLGGHKEVQPH | Function: Odorant receptor.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 36823
Sequence Length: 332
Subcellular Location: Cell membrane
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O60404 | MPGQNYRTISEFILSGFSAFPQQLLPVLFLLYLLMFLFTLLGNLLIMATVWIERRLHTPMYLFLCALSISEILFTVAITPRMLADLLFTHRSITFVACAIQMFFSFMFGFTHSFLLMVMGYDHYVTICHPLHYNMLMSPRGCAHLVAWTWAGGSVMGMMVTMMVFHLTFCGSNVIHHFLCHVLSLLKLACGSKTSSVIMGVMLVCVTALIGCLFLIILSFVFIVAAILRIPSAEGRHKTFSTCVSHLTVVVMHYSFASLIYLKPKGLHSMYSDALMATTYTVFTPFLSPIIFSLRNKELKNAINKNFCRRFCPLSS | Function: Odorant receptor.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 35721
Sequence Length: 316
Subcellular Location: Cell membrane
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Q8NGA6 | MQGLNHTSVSEFILVGFSAFPHLQLMLFLLFLLMYLFTLLGNLLIMATVWSERSLHMPMYLFLCALSITEILYTVAIIPRMLADLLSTQRSIAFLACASQMFFSFSFGFTHSFLLTVMGYDRYVAICHPLRYNVLMSLRGCTCRVGCSWAGGLVMGMVVTSAIFHLAFCGHKEIHHFFCHVPPLLKLACGDDVLVVAKGVGLVCITALLGCFLLILLSYAFIVAAILKIPSAEGRNKAFSTCASHLTVVVVHYGFASVIYLKPKGPQSPEGDTLMGITYTVLTPFLSPIIFSLRNKELKVAMKKTCFTKLFPQNC | Function: Odorant receptor.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 34900
Sequence Length: 315
Subcellular Location: Cell membrane
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P30954 | MLLCFRFGNQSMKRENFTLITDFVFQGFSSFHEQQITLFGVFLALYILTLAGNIIIVTIIRMDLHLHTPMYFFLSMLSTSETVYTLVILPRMLSSLVGMSQPISLAGCATQMFFFVTFGITNCFLLTAMGYDRYVAICNPLRYMVIMNKRLRIQLVLGACSIGLIVAITQVTSVFRLPFCARKVPHFFCDIRPVMKLSCIDTTVNEILTLIISVLVLVVPMGLVFISYVLIISTILKIASVEGRKKAFATCASHLTVVIVHYSCASIAYLKPKSENTREHDQLISVTYTVITPLLNPVVYTLRNKEVKDALCRAVGGKFS | Function: Odorant receptor.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 35925
Sequence Length: 320
Subcellular Location: Cell membrane
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Q5JRS4 | MPKLNSTFVTEFLFEGFSSFRRQHKLVFFVVFLTLYLLTLSGNVIIMTIIRLDHHLHTPMYFFLCMLSISETCYTVAIIPHMLSGLLNPHQPIATQSCATQLFFYLTFGINNCFLLTVMGYDRYVAICNPLRYSVIMGKRACIQLASGSLGIGLGMAIVQVTSVFGLPFCDAFVISHFFCDVRHLLKLACTDTTVNEIINFVVSVCVLVLPMGLVFISYVLIISTILKIASAEGQKKAFATCASHLTVVIIHYGCASIIYLKPKSQSSLGQDRLISVTYTHHSPTEPCCVQPEEQGGQRCSAQSRGAKNSVSLMKRGCEGFSFAFINMY | Function: Odorant receptor.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 36549
Sequence Length: 329
Subcellular Location: Cell membrane
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P0C629 | MPRPNFMAVTEFTFEGFSIFEWHHRLILFVIFLVLYVLTLASNAIILIVIRLNHQLHTPMYFFLSVLSISETYYTVAINPQMLSGLLSPQQTISIPGCAAQLFFYLTFGVNKCFLLTAMGYDHYVAICNPLQYSVIMGKKACIQLVSGSWNIGLSTAIIQVSSVFSLPFCDANLISHFFCDIRPIMKLACADTTIKEFITLLISLCVLVLPMVLIFISYVLIVTTILKIASAEGRRKAFATCASHLTVVIVHYGRTSFIYLKPKSQNSLQDRLISVTYTVITPLLNPVVYSLRNKEVKDALLRALGRKPLS | Function: Odorant receptor.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 34925
Sequence Length: 311
Subcellular Location: Cell membrane
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Q8NHC4 | MKRKNFTEVSEFIFLGFSSFGKHQITLFVVFLTVYILTLVANIIIVTIICIDHHLHTPMYFFLSMLASSETVYTLVIVPRMLLSLIFHNQPISLAGCATQMFFFVILATNNCFLLTAMGYDRYVAICRPLRYTVIMSKGLCAQLVCGSFGIGLTMAVLHVTAMFNLPFCGTVVDHFFCDIYPVMKLSCIDTTINEIINYGVSSFVIFVPIGLIFISYVLVISSILQIASAEGRKKTFATCVSHLTVVIVHCGCASIAYLKPKSESSIEKDLVLSVTYTIITPLLNPVVYSLRNKEVKDALCRVVGRNIS | Function: Olfactory receptor. Activated by the synthetic floral odorant, lyral, and by alpha-cedrene, a sesquiterpene constituent of cedarwood oil. Its activation increases intracellular Ca(2+) . Acts as a key regulator of myogenesis through its actions on cell migration and adhesion by activating the Ca(2+)-dependent AKT signal transduction pathway (By similarity). Acts also as a regulator of angiogenesis . Moreover, plays a role in the regulation of lipid accumulation in hepatocytes via the cAMP-PKA pathway . May be involved in sperm chemotaxis and motility (By similarity).
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 34401
Sequence Length: 309
Subcellular Location: Cell membrane
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Q62007 | MQRNNFTEVIEFVFLGFSSFGKHQITLFVVFLTIYILTLAGNIIIVTITHIDHHLHTPMYFFLSMLASSETVYTLVIVPRMLSSLIFYNLPISLAGCATQMFFFVTLATNNCFLLTAMGYDRYVAICNPLRYTIIMSKGMCALLVCGSLGTGLVMAVLHVPAMFHLPFCGTVVEHFFCDIYPVMKLSCVDTTVNEIINYGVSSFVILVPIGLIFISYVLIVSSILKIVSTEGQKKAFATCASHLTVVIVHYGCASIAYLKPKSESSVEKDLLLSVTYTIITPLLNPVVYSLRNKEVKDALCRAVGRNTS | Function: Olfactory receptor. Activated by the synthetic floral odorant, lyral, and by alpha-cedrene, a sesquiterpene constituent of cedarwood oil . Its activation increases intracellular Ca(2+) . Acts as a key regulator of myogenesis through its actions on cell migration and adhesion by activating the Ca(2+)-dependent AKT signal transduction pathway . Acts also as a regulator of angiogenesis . Moreover, plays a role in the regulation of lipid accumulation in hepatocytes via the cAMP-PKA pathway . Involved in sperm chemotaxis and motility .
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 34256
Sequence Length: 309
Subcellular Location: Cell membrane
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