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Transmission route efficacy and kinetics of Anaplasma phagocytophilum infection in white-footed mouse, Peromyscus leucopus. | Anaplasma phagocytophilum was used to infect Peromyscus leucopus mice by three routes of inoculation: infected tick infestation and intraperitoneal (IP) and subcutaneous (SQ) injection of infected tissue culture cells. A set of 12 mice were infected (four tick; four IP; and four SQ); and blood was drawn at 1; 3; 6; 9; 12; 15; 21; 28; 35; and 60 days post-infection and analyzed by use of a quantitative PCR assay to assess the level of infection. An additional set of 108 mice were infected (36 tick; 36 IP; 36 | 15682514 | [
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Transmission route efficacy and kinetics of Anaplasma phagocytophilum infection in white-footed mouse, Peromyscus leucopus. | SQ) and euthanized at 1; 3; 6; 9; 12; 15; 21; 28; and 35 days post-infection (four mice/time point); and blood; spleen; bone marrow; and bladder tissue samples were analyzed. Tick infection generally produced the highest average levels of infection and peaked at 9 days post-infestation in blood; spleen; and bone marrow and at 6 days after infestation in the bladder. IP injection resulted in levels of infection that peaked on day 6 (spleen) or 12 (bladder; bone marrow; and blood). A. phagocytophilum injecte | 15682514 | [
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Transmission route efficacy and kinetics of Anaplasma phagocytophilum infection in white-footed mouse, Peromyscus leucopus. | d SQ showed low levels of infection; and the day of peak infection varied. The average level of infection in the blood drawstressed mice was consistently higher and peaked earlier than infection in the non-stressed; euthanized mice. Xenodiagnosis was used to assay a third set of 12 mice (four tick; four IP; and four SQ) on days 7 and 14 post-infection and ticks fed on tick-infected mice showed the highest rate of PCR-positive test results at both time points (day 7; 22.2%; day 14; 17.3%). These data indicat | 15682514 | [
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Transmission route efficacy and kinetics of Anaplasma phagocytophilum infection in white-footed mouse, Peromyscus leucopus. | e that P. leucopus mice can be infected by tick infestation; IP injection; or SQ injection but that the kinetics and level of infection are quite variable among individual mice; may be influenced by the route of inoculation; and may be further altered by common laboratory procedures such as repeated collection of blood samples. | 15682514 | [
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Lack of susceptibility of guinea pigs and gerbils to experimental infection with Ehrlichia chaffeensis. | Guinea pigs and Mongolian gerbils were experimentally infected with Ehrlichia chaffeensis (St. Vincent strain; 10 passages in vitro). The infection was monitored by serial blood sampling for PCR and by xenodiagnosis with Amblyomma americanum larvae. Exposure to the pathogen was confirmed using serology. Neither guinea pigs nor gerbils were susceptible to infection with E. chaffeensis; and ticks fed upon these animals did not become infected with the pathogen. | 15682515 | [
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Molecular differentiation of metastriate tick immatures. | Hard ticks; family Ixodidae; are divided into two groups; the Metastriata and the Prostriata; based on morphological differences. In the United States; there are four medically important genera of the Ixodidae: Ixodes; Amblyomma; Dermacentor; and Rhipicephalus. Ixodes is the only genus in and representative of the Prostriata; whereas the latter three genera are members of the Metastriata. All developmental stages of the Prostriata can be easily differentiated from the Metastriata using morphology. Similarly | 15682516 | [
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Molecular differentiation of metastriate tick immatures. | ; the three Metastriate genera are highly identifiable as adults; yet as immatures; the discriminating characteristics can be difficult to use for differentiation; especially if the specimens are damaged or engorged with blood. All three Metastriate genera represent medically important vectors; thus accurate differentiation is necessary. To this end; we have developed a multiplexed-PCR diagnostic assay that; when combined with RFLP analysis will differentiate between the Metastriate genera--Amblyomma; Derma | 15682516 | [
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Molecular differentiation of metastriate tick immatures. | centor; Rhipicephalus; and Haemaphysalis based on the length of the PCR amplicon and subsequent restriction digestion profile. The intended use for this diagnostic is to verify morphological identifications; especially of immatures; as well as to identify samples destroyed for molecular analysis; which will lead to more accurate field data as well as implication of vectors in disease transmission. | 15682516 | [
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Pseudoepidemic of Q fever at an animal research facility. | Serum samples from people exposed to sheep at a research facility were evaluated by a commercial laboratory and resulted in an overall Coxiella burnetii seroprevalence of 75%. We interviewed individuals to determine exposure history and compatible illness; and retested their sera. Analysis indicated that the commercial laboratory was misinterpreting its results; when corrected; the seroprevalence dropped to 27%. Test kits of the brand used by the commercial laboratory gave equivalent results to the in-house | 15682517 | [
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Pseudoepidemic of Q fever at an animal research facility. | CDC assay when tested in parallel at CDC. Upon final analysis; only the attending veterinarian was confirmed as a Q fever case. This event resulted in increased risk reduction protocols at the research facility and improved public health communication among health authorities. This pseudoepidemic resulted from a lapse in laboratory quality control for testing. Similar errors can be avoided through standardization and improved review of laboratory procedures. | 15682517 | [
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Epidemiology of West Nile virus in Connecticut: a five-year analysis of mosquito data 1999-2003. | Two hundred and ten isolations of West Nile virus (WNV) were obtained from 17 mosquito species in six genera in statewide surveillance conducted in Connecticut from June through October; 1999-2003. Culex pipiens (86); Culex salinarius (32); Culex restuans (26); Culiseta melanura (32); and Aedes vexans (12) were implicated as the most likely vectors of WNV in the region based on virus isolation data. Culex pipiens was abundant from July through September and is likely involved in early season enzootic transm | 15682518 | [
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Epidemiology of West Nile virus in Connecticut: a five-year analysis of mosquito data 1999-2003. | ission and late season epizootic amplification of the virus in wild bird populations. Epidemic transmission of WNV to humans in urban locales is probable. The abundance of Cx. restuans in June and July and isolations of WNV in early July suggest that this species may play an important role as an enzootic vector involved in early amplification of WNV virus among wild birds. Its involvement as a bridge vector to humans is unlikely. Culex salinarius was the most frequently captured Culex species and was abunda | 15682518 | [
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Epidemiology of West Nile virus in Connecticut: a five-year analysis of mosquito data 1999-2003. | nt in August and September when virus activity was at its height. Frequent isolations of WNV from this species in September when the majority of human cases were reported in union with its abundance at this time of the year; demonstrated vector competence; and broad feeding habits; make Cx. salinarius a likely bridge vector to humans; horses and other mammals. Multiple isolations WNV from Cs. melanura collected in more rural locales in late August and September; provide supportive evidence to suggest that t | 15682518 | [
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Epidemiology of West Nile virus in Connecticut: a five-year analysis of mosquito data 1999-2003. | his predominant avian feeder may play a significant role in epizootic amplification of the virus among wild bird populations in these environs. Aedes vexans was the only species of Aedes or Ochlerotatus from which multiple isolations of WNV were made in more than one year and was among the most frequently trapped and abundant species throughout the season. Since Ae. vexans predominately feeds on mammals it is unlikely to play a significant role in epizootic amplification of WNV; however; because of its abun | 15682518 | [
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Epidemiology of West Nile virus in Connecticut: a five-year analysis of mosquito data 1999-2003. | dance and aggressive mammalian and human biting behavior it must receive strong consideration as a bridge vector to humans and horses. The occasional virus isolations obtained from Aedes cinereus (4); Uranotaenia sapphirina (3); Ochlerotatus canadensis (2); Ochlerotatus trivittatus (2); Ochlerotatus sollicitans (2); Ochlerotatus sticticus (2); Psorophora ferox (2); Anopheles punctipennis; Anopheles walkeri; Ochlerotatus cantator; Ochlerotatus taeniorhynchus; and Ochlerotatus triseriatus in conjunction with | 15682518 | [
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Epidemiology of West Nile virus in Connecticut: a five-year analysis of mosquito data 1999-2003. | their inefficient vector competency and host feeding preferences indicate that these species likely play a very minor role in either the enzootic maintenance or epizootic transmission of WNV in this region. The principal foci of WNV activity in Connecticut were identified as densely populated (>3;000 people/mi2) residential communities in coastal Fairfield and New Haven Counties; and in the case of 2002; similar locales in proximity of the city of Hartford in central Hartford County. In almost all instances | 15682518 | [
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Epidemiology of West Nile virus in Connecticut: a five-year analysis of mosquito data 1999-2003. | we observed a correlation both temporally and spatially between the isolation of WNV from field-collected mosquitoes and subsequent human cases in these locales. In most years the incidence of human cases closely paralleled the number of virus isolations made from mosquitoes with both peaks falling in early September. We conclude that the isolation of WNV from field-collected mosquitoes is a sensitive indicator of virus activity that is associated with the risk of human infection that habitually extends fr | 15682518 | [
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Epidemiology of West Nile virus in Connecticut: a five-year analysis of mosquito data 1999-2003. | om early August through the end of October in Connecticut. | 15682518 | [
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[Human T-cell lymphotropic virus in family members of seropositive blood donors: silent dissemination]. | To investigate human T-cell lymphotropic virus transmission among family members of asymptomatic carriers identified through blood donor screening tests; and to determine the most likely direction of transmission in sexual partners having the same (concordant) serological diagnosis.Between March 1997 and June 2003 the relatives and steady sexual partners of seropositive; asymptomatic blood donors were investigated for the presence of human T-cell lymphotropic virus type I and II. Diagnosis was based on enzy | 15682520 | [
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[Human T-cell lymphotropic virus in family members of seropositive blood donors: silent dissemination]. | me-linked immunoassay and Western blot. To determine the direction of transmission; demographic and behavioral data were obtained through questionnaires. All participants lived in the metropolitan region of Belo Horizonte capital of the state of Minas Gerais; Brazil.The overall prevalence of infection with human T-cell lymphotropic virus type was 25.9% among 352 relatives of 343 seropositive patients. The prevalence rates in mothers; sexual partners; and children of seropositive donors were 36.6% (15/41); 3 | 15682520 | [
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[Human T-cell lymphotropic virus in family members of seropositive blood donors: silent dissemination]. | 5.9% (42/117); and 17.5% (34/194); respectively. The demographic and behavioral data obtained suggest greater efficiency of male-to-female transmission.The observed prevalence rates suggest there is familial aggregation of human T-cell lymphotropic virus infection. The main transmission mode was horizontal (sexual). It is important to identify the presence of the virus in family members of infected individuals; even if they are asymptomatic. Doing so may lead to a better understanding of how the virus sprea | 15682520 | [
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[Human T-cell lymphotropic virus in family members of seropositive blood donors: silent dissemination]. | ds and more efficient measure for preventing disease transmission. | 15682520 | [
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Tuberculosis mortality trends in Taiwan: a resurgence of non-respiratory tuberculosis. | Population-based study in Taiwan.To determine the tuberculosis (TB) mortality trends in Taiwan by site and age.Mortality data for the years 1972 to 2001 were used to calculate the age/site-specific mortality rate (deaths per 100000 population). The year of change in the slope of mortality trends was estimated by iterative piecewise regression analysis.A levelling off in mortality trends was noted in the late 1980s for all age groups except those aged 75 and above. Except in the age group 25-44 years; the tr | 15682523 | [
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Tuberculosis mortality trends in Taiwan: a resurgence of non-respiratory tuberculosis. | ends in respiratory TB mortality showed a smooth decline. However; for non-respiratory TB mortality; a reversal of the decline was noted for all age groups since 1994-1995. A twofold increase in the number of deaths from central nervous system (CNS) and 'other' TB was noted. A marked increase in the number of deaths from old TB was noted since 1992-1996.TB mortality trends in Taiwan have not declined as expected over the past decade. The slowing down of the decline in TB mortality was mainly attributable to | 15682523 | [
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Tuberculosis mortality trends in Taiwan: a resurgence of non-respiratory tuberculosis. | a levelling off of respiratory TB mortality in the age group 25-44 and a reversal of non-respiratory TB mortality trends; especially in the 25-44 and > or =65 years age groups. | 15682523 | [
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Blood HbO2 and HbCO2 dissociation curves at varied O2, CO2, pH, 2,3-DPG and temperature levels. | New mathematical model equations for O2 and CO2 saturations of hemoglobin (S(HbO2) and S(HbCO2)) are developed here from the equilibrium binding of O2 and CO2 with hemoglobin inside RBCs. They are in the form of an invertible Hill-type equation with the apparent Hill coefficients K(HbO2) and K(HbCO2) in the expressions for S(HbO2) and S(HbCO2) dependent on the levels of O2 and CO2 partial pressures (P(O2) and P(CO2); pH; 2;3-DPG concentration; and temperature in blood. The invertibility of these new equatio | 15682524 | [
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Blood HbO2 and HbCO2 dissociation curves at varied O2, CO2, pH, 2,3-DPG and temperature levels. | ns allows P(O2) and P(CO2) to be computed efficiently from S(HbO2) and S(Hbco2) and vice-versa. The oxyhemoglobin (HbO2) and carbamino-hemoglobin (HbCO2) dissociation curves computed from these equations are in good agreement with the published experimental and theoretical curves in the literature. The model solutions describe that; at standard physiological conditions; the hemoglobin is about 97.2% saturated by O2 and the amino group of hemoglobin is about 13.1% saturated by CO2. The O2 and CO2 content in | 15682524 | [
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Blood HbO2 and HbCO2 dissociation curves at varied O2, CO2, pH, 2,3-DPG and temperature levels. | whole blood are also calculated here from the gas solubilities; hematocrits; and the new formulas for S(HbO2) and S(HbCO2). Because of the mathematical simplicity and invertibility; these new formulas can be conveniently used in the modeling of simultaneous transport and exchange of O2 and CO2 in the alveoli-blood and blood-tissue exchange systems. | 15682524 | [
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Effect of etomidate on endothelium-dependent relaxation induced by acetylcholine in rat aorta. | The goals of this in vitro study were to investigate effects of etomidate on endothelium-dependent relaxation induced by acetylcholine in rat aorta; and to elucidate the associated cellular mechanism. In endothelium-intact rings precontracted with phenylephrine 10(-6) M; dose-response curves for acetylcholine (10(-9) to 10(-5) M) and calcium ionophore (10(-9) to 10(-6) M) were generated in the presence and absence of etomidate (5 x10(-6) 10(-5) M). In endothelium-intact or -denuded rings precontracted with | 15682522 | [
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Effect of etomidate on endothelium-dependent relaxation induced by acetylcholine in rat aorta. | phenylephrine 10(-6) M; sodium nitroprusside (10(-9) to 10(-6) M) dose-response curves were generated in the presence and absence of etomidate (10(-5)M). Etomidate (5 x10(-6); 10(-5)M) produced a significant rightward shift in the dose-response curves induced by acetylcholine (receptor-mediated endothelium-dependent agonist) and calcium ionophore A23187 (non receptor-mediated endothelium-dependent agonist). Etomidate (10(-5)M) had no effect on sodium nitroprusside (endothelium-independent nitric oxide donor | 15682522 | [
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Effect of etomidate on endothelium-dependent relaxation induced by acetylcholine in rat aorta. | )-induced vasorelaxant response in both endothelium-intact and -denuded rings. These results indicate that etomidate at clinically relevant concentrations attenuates endothelium-dependent relaxation induced by acetylcholine by an acting at a site distal to the endothelial muscarinic receptor; but proximal to guanylate cyclase activation of vascular smooth muscle in rat aorta. | 15682522 | [
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Weight gain and cardiopulmonary bypass. 1980. | nan | 15682525 | [
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Accuracy of continuous nocturnal glucose screening after 48 and 72 hours in type 2 diabetes patients on combined oral and insulin therapy. | To evaluate the accuracy of nocturnal continuous glucose monitoring by CGMS.A CGMS was inserted in 14 type 2 diabetic patients on combined oral and insulin therapy at altogether 15 occasions. During the second (48 hours) and third (72 hours) night of registration each subject was observed and plasma glucose was analysed seven times during the night by venous sampling and compared to CGMS. These venous values were not used for calibration of the sensor. Pairs of data were analysed using correlation coefficie | 15682526 | [
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Accuracy of continuous nocturnal glucose screening after 48 and 72 hours in type 2 diabetes patients on combined oral and insulin therapy. | nt; Bland-Altman graphs and Clarke Error Grid analysis.32% of CGMS data did not meet the quality criteria for optimal accuracy and were excluded. A correlation coefficient of 0.80 (p < 0.0001) was seen after 48 hours and a lower coefficient of 0.33 (p = 0.0082) after 72 hours. Bland-Altman analyses demonstrated that the dispersion of the values around the mean of differences was wider after 72 hours as compared to after 48 hours. In the Clark Error Grid analysis 100% of data were within zones A and B after | 15682526 | [
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Accuracy of continuous nocturnal glucose screening after 48 and 72 hours in type 2 diabetes patients on combined oral and insulin therapy. | 48 hours; with 60% in zone A. After 72 hours only 44% were in zone A and 7% of data were in the clinically unacceptable zone D.The MiniMed Medtronic CGMS has acceptable nocturnal accuracy after 48 hours of registration; but the accuracy thereafter deteriorates with time; implicating that the CGMS thereafter may prove less useful for nocturnal monitoring. | 15682526 | [
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Nebulized fentanyl provides subjective improvements for patients with dyspnea. | nan | 15682527 | [
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A day in the life of a manager: incorporating leadership, mentoring, and role modeling. | nan | 15682530 | [
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Dr John Bevis (1693-1771), contributor of astronomical and meterological articles in the Gentleman's Magazine. | nan | 15682532 | [
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Dade Parish registers. | Over the last thirty years parish registers have been used with great effect to throw light on the population history of England. To decide whether a parish register was suitable to be used for such purposes systems were developed to assess the quality of that register; and in particular to assess whether a satisfactory percentage of the baptisms; marriages and burials that took place in that parish are likely to have been entered in the parish register. However; until recently relatively little considerati | 15682534 | [
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Dade Parish registers. | on has been given to the quality of the individual entries in a parish register; and still less as to why entries of above average quality appear in a given register. This paper is concerned with the extended parish registers that are to be found in the late eighteenth and early nineteenth century; in particular the so-called Dade registers that are to be found in the dioceses of York and Chester; which contain substantially more information than most parish registers of the period. It will; it is hoped; le | 15682534 | [
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Conference motions: there is still time to have your way. | nan | 15682538 | [
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The Hippocratic surgical instrumentarium: A study in nomenclature. | Precisely what surgical tools were available to Greek surgeons in the fifth and fourth centuries BCE? In the absence of material survivals we must depend mainly on descriptions of instruments and their use in the Hippocratic Corpus to answer this question. We can also speculate on why so few Hippocratic instruments come down to us in contrast to the relative abundance of survivals from the Roman Empire. | 15682536 | [
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Possible human sacrifice at the origins of Rome: novel skeletal evidences. | Recent archaeological excavations at the Carcer/Tullianum; in the Roman Forum; allowed the unexpected recovery of human burials associated with the very early foundations of the monument; at the beginning of the iron age. The study of these burials resulted in interesting paleopathological discoveries; concerning the skeleton of a strongly-built male; radiocarbon-dated between 830 and 780 BC. The telltale posture of the skeleton and the presence of a massive perimortal blunt force trauma of the skull shed l | 15682539 | [
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Possible human sacrifice at the origins of Rome: novel skeletal evidences. | ight on the mode and circumstances of the death of this subject; and are suggestive of ritual sacrifice. The archaeological; mythological and historical backgrounds; combined with the paleopathological evidence; help us to get a glimpse of life and death at the origins of Rome. | 15682539 | [
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[The historical relationship between ethics and medicine]. | Did medicine need philosophy to create a medical ethics? The article analyzes the historical origins of medical ethics; considered as a compound of deontology and clinical ethics. | 15682537 | [
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[Aldo Castellani (1874-1971). A century-long scientific travel]. | Aldo Castellani is an international scientist; well known for his essential contribution to the aetiological researches on sleeping-sickness. During his career; that took him to many parts of the world; he studied a number of tropical diseases and he obtained important results; like the discovery of new therapies and some fundamental laboratory techniques. His academic career lasted about seventy years; during which he increased thanks to his works the scientific knowledge of Italian and foreign universitie | 15682541 | [
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[Aldo Castellani (1874-1971). A century-long scientific travel]. | s. Basic in his life is the period in which he headed the Institute of Tropical Medicine at the University of Rome; making important choices for Italian public health: for instance; during the Italian-Ethiopian War he proved to be an "additional weapon" for the Italian Army. He spent the last part of his life travelling; but he remained personal physician to the former Italian king Umberto II; exiled in Cascais and professor in the Tropical Medicine Institute of Lisboa. The aim of the authors; in homage to | 15682541 | [
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[Aldo Castellani (1874-1971). A century-long scientific travel]. | Aldo Castellani's memory; is to emend; as far as possible; the occasional errors in the papers dedicated to him. | 15682541 | [
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[Mummies as therapeutical treatments]. | Mummies have always exerted a strong suggestion on mentality through centuries. They have been considered magical objects; possessing mysterious powers and able to protect from dangers. Pieces or mummy were employed as amulets to preserve life. In the modern age physicians and apothecaries began to use it for therapeutical treatments. This article concerns the therapeutic employ and the different compositions and uses of mummial remedies from early modern age to XVIII century. | 15682542 | [
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[Medical practice in Rome during the XVI century]. | S. Filippo Neri (1515-1595); founder of the Congregazione dell'Oratorio in Rome; was a longly debated clinic case for his various pathologies. Eminent scientists; like B. Eustachio and A. Cesalpino; treated him and drew up clinical reports; which were inserted in the Canonization Process and also published as scientific works; and which give useful informations about the history of medicine in the second half of the 16th century. Those reports relate; among others; about many diseases like frequent heart pa | 15682543 | [
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[Medical practice in Rome during the XVI century]. | lpitation; shaking tremors heat flame and bronchitic fever episodes; that since hte age of thirty affected the saint. Autopsy revealed cardiac hypertrophia and pulmonary artery dilatation over twice the normal diameter. G. M. Lancisi was the first who formulated the hypothesis of an artery aneurysm; which; according to the present knowledge; can be produced by a post-stenotic dilatation of the pulmonary valve and/or pulmonary hypertension. Tremors and flames can be attributed to hyperthyroidism. Doctors who | 15682543 | [
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[Medical practice in Rome during the XVI century]. | treated S. Filippo Neri and who shoved to be aware of his psychology; considered his pathology due to supernatural causes. Their conclusions can be understood basing on the medical way of thinking of that age; which was still linked to ancient medicine and limited by the biological and medical knowledge of the time. | 15682543 | [
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Patient care vs. corporate connections: Cleveland Clinic wants to change but won't cut ties to industry. | nan | 15682548 | [
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[On paludism/malaria and other intermittent, tertian and quartan fevers in France from the XVIIIth to the XXth century]. | This article aims at bringing an update on paludism and intermittent fevers which plagued France until the end of the XIXth century. Relying on present day medical data; an attempt at interpreting demographical data is presented in order to draw a social and physical geography of paludism and intermittent fevers in XVIIIth and XIXth century France. A history of paludism over two centuries is also sketched. It allows the observation of fever fluctuations; dependent on political events or economic activities | 15682550 | [
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[On paludism/malaria and other intermittent, tertian and quartan fevers in France from the XVIIIth to the XXth century]. | of the time. | 15682550 | [
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[Ergonomic pathology of Pandolfo III Malatesta]. | Pandolfo III Malatesta; Prince of Fano; was born in 1370 from Galeotto Malatesta and Gentile Varano. He was a leading figure of the Italian Renaissance and Captain General of the troops of the Republic of Venice in the war against the Visconti of Milan and the Hungarians. The Prince represents a typical example of a XVth century condottiere. He was a strong; active man; a valiant soldier and horseman at times impulsive and; as somebody noticed; a lover of "charming women". As a matter of fact during his lif | 15682551 | [
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[Ergonomic pathology of Pandolfo III Malatesta]. | e he married three noble women; but had only illegitimate descendants. Pandolfo died on October 3; 1427; at the age of 57; soon after his third marriage to a woman who was 40 years younger. His natural mummy; resumed in 1995; was submitted to conventional X-ray; to autopsy and to videographic examination of the mouth making possible the diagnosis of prostatic hyperplasia and a number of skeletal-muscle acquired lesions. The present paper analyses and correlates both the life style of Pandolfo and the muscle | 15682551 | [
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[Ergonomic pathology of Pandolfo III Malatesta]. | s-skeleton lesions. The results showed a strict correlation allowing the elaboration of a typical ergonomic model: as a matter of fact the Prince was a soldier; constantly dressing a heavy suit of armour; using cold steel such as the sword and riding as horseman; fighting during the battles or jousting during the chivalrous tournaments. | 15682551 | [
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[The madness of Herakles in Euripides and Sophocles]. | In the ancient Greek world madness was conceived as a punishment sent by the gods to men found guilty of various sins. Heralkes; who kills his wife Megara and their sons; is the best example of Greek literature offers of the tragic consequences of mental disease. The article conducts a medical observation of Sophocles' and Euripides' descriptions of Herakles' insanity. | 15682552 | [
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[Death from scurvy on Vasco da Gama's first journey to India (1497-1499)]. | Alvaro Velho's account of Vasco da Gama's first journey to India (1497-1499); describing; among other things; the anguish and pains suffered by the crew because of scurvy; represents; with the striking vividness of its images; one of the oldest references to a terrifying disease to which seamen then began to be exposed; as well as to the use of fresh fruit; and vegetables as a successful method to rescue them; and in a certain degree; from this distemper at sea. This paper analyzes Alvaro Velho's statements | 15682553 | [
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[Death from scurvy on Vasco da Gama's first journey to India (1497-1499)]. | from a scientific point of view; whereas it stresses the accent on what contemporary Portuguese historians; and chroniclers; as well as foreign travellers; and merchants; thought about it; often misinterpretating its causes; just like Alvaro Velho did. | 15682553 | [
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What was classical genetics? | I present an account of classical genetics to challenge theory-biased approaches in the philosophy of science. Philosophers typically assume that scientific knowledge is ultimately structured by explanatory reasoning and that research programs in well-established sciences are organized around efforts to fill out a central theory and extend its explanatory range. In the case of classical genetics; philosophers assume that the knowledge was structured by T. H. Morgan's theory of transmission and that research | 15682554 | [
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What was classical genetics? | throughout the later 1920s; 30s; and 40s was organized around efforts to further validate; develop; and extend this theory; I show that classical genetics was structured by an integration of explanatory reasoning (associated with the transmission theory) and investigative strategies (such as the 'genetic approach'). The investigative strategies; which have been overlooked in historical and philosophical accounts; were as important as the so-called laws of Mendelian genetics. By the later 1920s; geneticists | 15682554 | [
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What was classical genetics? | of the Morgan school were no longer organizing research around the goal of explaining inheritance patterns; rather; they were using genetics to investigate a range of biological phenomena that extended well beyond the explanatory domain of transmission theories. Theory-biased approaches in history and philosophy of science fail to reveal the overall structure of scientific knowledge and obscure the way it functions. | 15682554 | [
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Developing World/Indian optometry and emigration. | nan | 15682558 | [
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The eye care profile and outcomes of multi-handicapped adults residing in Wayne County, Michigan group homes. | Patients with multi-handicaps present clinical challenges and are underserved. Central nervous system dysfunction and ocular disorders with this population are prevalent and well-documented. However; vision care outcomes data are limited and specific visual function recommendations to caregivers are rarely cited.The charts of 110 multiply handicapped adults residing in 22 group homes in Wayne County. Michigan were retrospectively studied to identify ocular profiles and predictors of visual function.Sixty-fi | 15682559 | [
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The eye care profile and outcomes of multi-handicapped adults residing in Wayne County, Michigan group homes. | ve percent of the subjects were male and 80% were ages 26 to 55 years. There was no expressive language in 41%; and 37% were non-ambulatory. The median visual impairment level was moderate in both eyes (based on WHO). Significant associations between visual impairment level and subpopulations (such as seizure disorder; mental retardation without specific etiology; cerebral palsy; and Down syndrome) were identified. Successful spectacle wear statistically increased with higher refractive errors. Associations | 15682559 | [
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The eye care profile and outcomes of multi-handicapped adults residing in Wayne County, Michigan group homes. | between cataract; nystagmus; and strabismus with particular subpopulations were significant (all P values < 0.0182).Clinicians who evaluate patients with multi-handicaps have few known predictors of treatment success. This study indicates that useful predictors of visual function can be made from refractive error; systemic conditions; and ocular diagnoses. No significant relationship was found with cognitive level and either vision impairment or spectacle use. The authors attribute successful implementatio | 15682559 | [
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A case report and review of filamentary keratitis. | Filamentary keratitis is most often a chronic corneal condition; characterized by filaments attached at one or both ends to the cornea. Patients often experience foreign body sensation; grittiness; discomfort; photophobia; blepharospasm; and increased blinking. Filamentary keratitis is commonly the result of aqueous deficient dry eye syndrome. Management options include lubrication; punctal occlusion; removal of filaments; hypertonic saline; mucolytic agents; anti-inflammatory agents; and therapeutic contac | 15682560 | [
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A case report and review of filamentary keratitis. | t lenses.A 58-year-old man came to us with acute symptoms of pain; photophobia; and redness x 2 days 0.S. The diagnosis of filamentary keratitis was made based on the clinical findings of positively staining mucus strands attached to the superior cornea. The patient was also found to have dry eye; blepharitis; and floppy eyelid syndrome. Numerous treatment regimens were implemented; including lubrication with non-preserved artificial tears; lubricating ointment; and topical steroids. The patient's condition | 15682560 | [
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A case report and review of filamentary keratitis. | was finally best managed with silicone plug punctal occlusion and therapeutic contact lenses.Filamentary keratitis can be a recurrent and incapacitating condition that may prove difficult to manage. | 15682560 | [
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A retrospective study on presbyopia onset and progression in a Hispanic population. | This study evaluates differences in age and presbyopia progression between an ethnic Hispanic and a non-Hispanic patient population.Patient records from the Optometric Center of Los Angeles were examined retrospectively from 1998 through 2001. The first part of the study compared ages at onset and progression of presbyopia as a function of ethnicity. The second part of the study compared the amplitude of accommodation for the cohort of patients to Hofstetter's expected norms.A total of 332 patient records w | 15682561 | [
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A retrospective study on presbyopia onset and progression in a Hispanic population. | ere evaluated: 61% (n = 203) Hispanic and 39% (n = 129) non-Hispanic. For an add power of +0.75 D; presbyopia developed in the reviewed Hispanic population at 39.31 years of age in comparison to development in non-Hispanics at 40.22 years. Hispanics also had a similar progression of reading add power (0.105 D/year) as compared to non-Hispanics (0.097 D/year) (t= 0.798; p = 0.43). The progression of amplitude of accommodation for the Hispanic (amplitude = 11.2 - 0.132 x age) and non-Hispanic populations (amp | 15682561 | [
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A retrospective study on presbyopia onset and progression in a Hispanic population. | litude = 9.72 - 0.18 x age) (t= 0.0997; p = 0.92) were comparable; but both groups show a slower decline of amplitude when compared to Hofstetter's norms (p< 0.001).No statistically significant difference in the age at onset and progression of presbyopia was found between Hispanic and non-Hispanic patients; however; both groups of patients have a later onset and slower progression of presbyopia when compared to Hofstetter's norms. | 15682561 | [
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Effects of two eye drop products on computer users with subjective ocular discomfort. | An increasing number of people seek medical attention for symptoms of visual discomfort due to computer vision syndrome (CVS). We compared the efficacy and adverse event rates of a new eye lubricant; OptiZen (InnoZen; Inc.; polysorbate 80 0.5%) and Visine Original (Pfizer Consumer Healthcare; tetrahydrozoline HCl 0.05%).In this double-blind parallel arm trial; 50 healthy men and women; ages 18 to 65 years; with symptoms of CVS who use a video display terminal for a minimum of 4 hours per day were randomized | 15682562 | [
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Effects of two eye drop products on computer users with subjective ocular discomfort. | to OptiZen (n = 25) or Visine Original (n= 25); 1 to 2 drops b.i.d. for 5 days. The primary end-points were ocular discomfort and adverse events.OptiZen and Visine Original had similar efficacy in alleviating symptoms of ocular discomfort (odds ratio of 1.23 [95% confidence interval; 0.63 to 2.42]; P= 0.55). OptiZen and Visine Original were very similar with respect to odds ratios and 95% confidence interval (CI) for each of the measurement times (P= 0.72). Visine Original users reported a significantly hi | 15682562 | [
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Effects of two eye drop products on computer users with subjective ocular discomfort. | gher incidence of temporary ocular stinging/burning immediately after drug instillation (28%; 7/25) than did OptiZen users (4%; 1/24) (P= 0.05). Patients using OptiZen were 89% less likely to have stinging/burning effects than those patients using Visine Original (95% CI: 0.01 to 0.95).OptiZen and Visine Original are effective at alleviating ocular discomfort associated with prolonged computer use. Adverse event findings suggest that OptiZen causes less ocular discomfort on instillation; potentially attribu | 15682562 | [
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Effects of two eye drop products on computer users with subjective ocular discomfort. | table to its milder ingredient profile. | 15682562 | [
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A formal approach to HIPAA risk analysis in the optometric practice. | nan | 15682563 | [
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Buying time, saving lives: hospital rapid response teams find ways to reduce mortality outside the ICU. | Many studies in recent years have shown that many critical cardiovascular and respiratory events in hospitals are preceded by warning signs hours before the events themselves occur. Two facilities have created award-winning rapid response teams that are making a difference for not only the patients who encounter these critical events but the entire organization as well. | 15682566 | [
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