ENTITY
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DEFINITION
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ALIASES
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NAME
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C1333579
This gene is involved in signal transduction.
FRS2beta|fibroblast growth factor receptor substrate 3|SUC1-ASSOCIATED NEUROTROPHIC FACTOR TARGET 2|FRS2-BETA|FRS2B|FRS3 gene|Fibroblast Growth Factor Receptor Substrate 3 Gene|FGFR SUBSTRATE 3|FRS3 Gene|SNT-2|FRS3|FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 3|SNT2
FRS3 gene
C1516966
The tissue of the esophageal wall. It is composed of mucosa, a muscular coat, and a serosal surface.
Esophageal Tissue
Esophageal Tissue
C0039871
A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Tris(1-aziridinyl)phosphine Sulfide|triethylene thiophosphoramide|TESPA|Thio Tepa|thiophosphoramide|1,1',1"-phosphinothioylidynetrisaziridine|Triethylenethiophosphoramide|THIOTEPA|Thiotepa (substance)|1,1',1''-Phosphinothioylidynetrisaziridine|Aziridine, 1,1',1''-phosphinothioylidynetris-|Product containing thiotepa (medicinal product)|triethylenethiophosphoramide|N,N', N''-Triethylenethiophosphoramide|Triethylene thiophosphoramide|Thiofosfamide|Tris(1-aziridinyl)phosphine sulfide|Thiophosphamide|1,1',1''-phosphinothioyldynetrisaziridine|Thiophosphoramide|thiophosphamide|Thiotepa-containing product|N,N',N''-triethylenethiophosphoramide|TSPA|thiofosfamide|tris(1-aziridinyl)phosphine sulfide|1,1',1''-Phosphinothioyldynetrisaziridine|Thiotepa|thiotepa|Triethylene Thiophosphoramide|Thio-Tepa
thiotepa
C0002844
Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.
Androgen|Androgen Receptor Agonists|Agonists, Androgen Receptor|Therapeutic Androgen|Agents, Androgenic|Androgen preparation, NOS|Compounds, Androgenic|Androgen receptor agonist|Androgenic Agents|Androgenic drug, NOS|Androgen-containing product|Substance with androgen receptor agonist mechanism of action (substance)|Androgenic Compounds|Product containing androgen (product)|ANDROGENIC PREPARATIONS|androgens|ANDROGENS|Androgen, NOS|Androgen (substance)|Androgens|Receptor Agonists, Androgen|Androgen preparation|Substance with androgen receptor agonist mechanism of action|Androgen receptor agonist-containing product|androgen|Product containing androgen receptor agonist (product)
Androgens
C0003241
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Antibody|Antibody-containing product|Antibodies|antibodies|Antibody, NOS|antibody|Ab|Antibody (substance)|Product containing antibody (product)
Antibodies
C0138741
A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.
gamma Seminoprotein|Prostate-Specific Antigen|Kallikrein, hK3|Prostate Specific Antigen|prostate specific antigen|Prostate-specific antigen|Kallikrein hK3|gamma seminoprotein|Seminin|PSA - prostate specific antigen|hK3 Kallikrein|prostate specific ag|P-30 antigen|prostate-specific antigen|Prostate specific antigen|PSA|gamma-Seminoprotein|prostate specific antigen (PSA)|Semenogelase|Prostate specific antigen (substance)|psa antigen
Prostate-Specific Antigen
C0002844
Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.
Androgen|Androgen Receptor Agonists|Agonists, Androgen Receptor|Therapeutic Androgen|Agents, Androgenic|Androgen preparation, NOS|Compounds, Androgenic|Androgen receptor agonist|Androgenic Agents|Androgenic drug, NOS|Androgen-containing product|Substance with androgen receptor agonist mechanism of action (substance)|Androgenic Compounds|Product containing androgen (product)|ANDROGENIC PREPARATIONS|androgens|ANDROGENS|Androgen, NOS|Androgen (substance)|Androgens|Receptor Agonists, Androgen|Androgen preparation|Substance with androgen receptor agonist mechanism of action|Androgen receptor agonist-containing product|androgen|Product containing androgen receptor agonist (product)
Androgens
C0062773
Class of enzymes that catalyze the acetylation of specific lysine residues of histones, proteins that organize eukaryotic DNA into chromatin. Among the proteins that exhibit histone acetyltransferase activity are various transcription factor coactivators. E.C. 2.3.1.48.
Histone acetyltransferase|histone acetyltransferase|Acetyltransferases, Histone|Histone Acetylase|Acetylase, Histone|HAT|EC 2.3.1.48|Histone acetyltransferase (substance)|Acetyltransferase, Histone|Histone Acetyltransferases|histone acetyltransferases (HAT)|Histone Acetyltransferase
histone acetyltransferase
C0080055
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
p53 Antigen|Phosphoprotein, pp53|p53 oncoprotein|protein p53|p53 proteins|TRP53 Protein|TP53 Protein|p53 protein|Tumor Suppressor Protein p53|Cellular Tumor Antigen p53|p53 Tumor Suppressor Protein|Oncoprotein p53|pp53 Phosphoprotein
Protein p53
C0090388
A large family of signal-transducing adaptor proteins present in wide variety of eukaryotes. They are PHOSPHOSERINE and PHOSPHOTHREONINE binding proteins involved in important cellular processes including SIGNAL TRANSDUCTION; CELL CYCLE control; APOPTOSIS; and cellular stress responses. 14-3-3 proteins function by interacting with other signal-transducing proteins and effecting changes in their enzymatic activity and subcellular localization. The name 14-3-3 derives from numerical designations used in the original fractionation patterns of the proteins.
14-3-3 Protein, Brain|14-3-3 Proteins|Brain 14-3-3 Protein|Brain 14 3 3 Protein|14 3 3 Proteins|14-3-3 protein (substance)|14 3 3 Protein|protein 14-3-3|14-3-3 Protein|14-3-3 protein|Protein 14-3-3
14-3-3 Proteins
C0245382
A multifunctional galactin initially discovered as a macrophage antigen that binds to IMMUNOGLOBULIN E, and as 29-35-kDa lectin that binds LAMININ. It is involved in a variety of biological events including interactions with galactose-containing glycoconjugates, cell proliferation, CELL DIFFERENTIATION, and APOPTOSIS.
L30 Lectin|Binding Protein, IgE|L 29 Lectin|Mac 2 Antigen|L-34|Galectin-3|IgEBP|CBP-35|L-29 Lectin|galectin-3|Carbohydrate Binding Protein 35|Carbohydrate-Binding Protein 35|Macrophage-2 Antigen|Macrophage 2 Antigen|galectin 3|Protein, IgE Binding|Mac-2 Antigen|Antigen, Macrophage-2|Galectin 3|IgE Binding Protein|LGALS3|CBP-30|Galectin-3 (substance)|L-31|Antigen, Mac-2|Epsilon-Binding Protein|HL-29|CBP35|Epsilon Binding Protein
Galectin 3
C0245382
A multifunctional galactin initially discovered as a macrophage antigen that binds to IMMUNOGLOBULIN E, and as 29-35-kDa lectin that binds LAMININ. It is involved in a variety of biological events including interactions with galactose-containing glycoconjugates, cell proliferation, CELL DIFFERENTIATION, and APOPTOSIS.
L30 Lectin|Binding Protein, IgE|L 29 Lectin|Mac 2 Antigen|L-34|Galectin-3|IgEBP|CBP-35|L-29 Lectin|galectin-3|Carbohydrate Binding Protein 35|Carbohydrate-Binding Protein 35|Macrophage-2 Antigen|Macrophage 2 Antigen|galectin 3|Protein, IgE Binding|Mac-2 Antigen|Antigen, Macrophage-2|Galectin 3|IgE Binding Protein|LGALS3|CBP-30|Galectin-3 (substance)|L-31|Antigen, Mac-2|Epsilon-Binding Protein|HL-29|CBP35|Epsilon Binding Protein
Galectin 3
C0072442
null
prothymosin alpha1|prothymosin alpha
prothymosin alpha
C0072442
null
prothymosin alpha1|prothymosin alpha
prothymosin alpha
C0025201
Mammalian pigment cells that produce MELANINS, pigments found mainly in the EPIDERMIS, but also in the eyes and the hair, by a process called melanogenesis. Coloration can be altered by the number of melanocytes or the amount of pigment produced and stored in the organelles called MELANOSOMES. The large non-mammalian melanin-containing cells are called MELANOPHORES.
melanocytes|Melanocyte|melanocyte|Melanocyte (cell)|Melanocytes
melanocyte
C0440745
null
pigment cell|Pigment cell (cell)|cells pigmented|Pigment cells|Cell pigment
Pigment cell
C0162763
A likely membrane attachment device, farnesylation involves enzymatic covalent addition of farnesyl group(s) (three isoprene units) to polypeptide chains that contain the carboxyl terminal motif CAAX. The addition involves cleavage and addition to the free thiol group of cysteine moiety, and methylation of the free carboxylate group on the protein's carboxyl terminus.
farnesylation|Farnesylation|Farnesylation Process
Farnesylation
C1435338
null
nutlin-3
nutlin 3
C0035668
A polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached. RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
RNA|RNA - Ribonucleic acid|Acid, Ribonucleic|RNA Gene Products|Gene Products, RNA|Ribonucleic Acid|Ribonucleic acid|rnas|Ribonucleic acid (RNA)|RNA, Non-Polyadenylated|Non Polyadenylated RNA|Non-Polyadenylated RNA|Ribonucleic acid (substance)|Ribonucleic acid, NOS|Ribonucleic acids|ribonucleic acid|RNA, Non Polyadenylated|ribonucleic acid (RNA)|rna
RNA
C1136452
null
null
lamellarin D
C0220650
Cancer that has spread from the original (primary) tumor to the brain.
tumors metastatic to brain|Metastatic malignant neoplasm to brain|metastatic brain tumor|brain secondary|cancer, metastatic to brain|Metast. to brain parenchyma, NOS|Brain Metastasis|Secondary cancer of brain|brain tumor metastatic|metastatic brain cancer|Metastases to brain parenchyma, NOS|Secondary malignant neoplasm of brain (disorder)|Metastatic Neoplasm to the Brain|brain metastasis|Brain metastasis|Metastatic malignant neoplasm to brain, NOS|metastasis to brain|Metastatic Tumor to the Brain|metastatic cancer to brain|brain cancers metastatic|Brain Metastases|Metastatic Malignant Neoplasm to the Brain|brain cancer metastatic|brain metastatic tumor|brain metastatic tumors|Metastatic Malignant Neoplasm in the Brain|secondary brain cancer|brain metastases|Secondary malignant neoplasm of brain, NOS|Secondary malignant neoplasm of brain|brain cancer secondary|cancer metastatic to brain|metastasis brain|Cancer metastatic to brain|Metastasis to brain
Metastatic malignant neoplasm to brain
C0380603
A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).
FGF 2|Fibroblast Growth Factor-2|basic fibroblast growth factor|HBGF-2|Heparin-Binding Growth Factor Class II|fibroblast growth factor 2|Fibroblast Growth Factor, Basic|bfgf|Cartilage Derived Growth Factor|Class II Heparin-Binding Growth Factor|Basic Fibroblast Growth Factor|fgf2|Prostatropin|Fibroblast Growth Factor 2|bFGF|FGF2|FGF-2|Prostate Epithelial Cell Growth Factor|fibroblast growth factor 2 (FGF-2)|Cartilage-Derived Growth Factor
Fibroblast Growth Factor 2
C0919281
null
iressa|Iressa
Iressa
C1135136
null
tarceva|Tarceva
Tarceva
C0221910
Flat cell that looks like a fish scale under a microscope. These cells cover inside and outside surfaces of the body. They are found in the tissues that form the surface of the skin, the lining of the hollow organs of the body (such as the bladder, kidney, and uterus), and the passages of the respiratory and digestive tracts.
Cell, Squamous Epithelial|Epithelial Cells, Squamous|Cells, Squamous|Squamous epithelial cell|Epithelial Cell, Squamous|Squamous Cell|Squamous Epithelial Cell|squamous cell|Squamous epithelial cell (cell)|squamous cells|Squamous Cells|Squamous cell|epithelial squamous cell|squamous epithelial cell|Cell, Squamous|Cells, Squamous Epithelial|Squamous Epithelial Cells
Squamous Epithelial Cells
C1449699
The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.
Tumor Loads|Load, Tumor|Tumor Burden|Loads, Tumor|tumor burden|tumor load|Tumor Load|Burden, Tumor
Tumor Burden
C0006366
Glands situated on each side of the prostate that secrete a fluid component of the seminal fluid into the urethra.
Bulbourethral gland structure|cowper's gland|Cowper's glands|cowpers glands|Bulbourethral gland|Bulbourethral Glands|Glandula bulbourethralis|Cowper Gland|Glands, Cowper's|cowper glands|Cowpers gland|Glands, Bulbourethral|Cowper's Gland|cowper gland|bulbourethral gland|Bulbourethral Gland|Cowper's Glands|Glandula bulbo-urethralis|Gland, Bulbourethral|Cowper gland|Bulbourethral gland structure (body structure)|Bulbo-urethral gland|Cowpers Glands|Cowper's gland|cowper's glands|cowpers gland|bulbourethral glands|GLAND, BULBOURETHRAL|Cowper Glands
Bulbourethral gland structure
C0598658
null
null
antibody conjugate
C0038148
The most potent androgen, required for sex development. Dihydrotestosterone is synthesized from testosterone in the prostate gland, testes, hair follicles and adrenal glands by 5-alpha reductase. Dihydrotestosterone exerts its action similar to testosterone, which binds to and activates specific nuclear androgen receptors. After translocation into the nucleus, the activated hormone-receptor complex binds to the androgen response elements on the DNA and activates gene expressions that are required for sex development. Dihydrotestosterone is responsible for the formation of male primary sex characteristics and most male secondary sex characteristics during puberty, such as muscular growth, facial and body hair growth, and deepening of the voice.
Stanolone preparation|dihydrotestosterone|Androstan-3-one, 17-hydroxy-, (5alpha,17beta)-|Stanolone|5-alpha-DHT|5-alpha-Dihydrotestosterone|Dihydrotestosterone, 5-alpha|4-Dihydrotestosterone preparation|5 alpha-dihydrotestosterone|Androstanolone|5-alpha-dihydrotestosterone|5alpha-Dihydrotestosterone|5 alpha DHT|Testosterone, dihydro-|Dihydrotestosterone|STANOLONE|Dihydrotestosteron|Androstanolone preparation|4-dihydrotestosterone|androstanolone|DHT - 5-alpha-dihydrotestosterone|17β-hydroxy-3-oxo-5α-androstanone|(5-alpha, 17-beta)-17-hydroxyandrostan-3-one|(5alpha,17beta)-17-hydroxyandrostan-3-one|17beta-Hydroxyandrostan-3-one|Product containing dihydrotestosterone (medicinal product)|4-Dihydrotestosterone|Dihydrotestostérone|Dihydrotestosterone (substance)|Dihydrotestosterone preparation|Therapeutic Androstanolone|17beta-Hydroxy-5alpha-androstane-3-one|(5alpha,17beta)-17-Hydroxyandrostan-3-one|17beta-Hydroxy-5alpha-androstan-3-one|stanolone|DHT|5 alpha-Dihydrotestosterone|17beta Hydroxy 5alpha Androstan 3 One|Dihydrotestosterone-containing product|5 alpha Dihydrotestosterone|17beta-Hydroxy-3-androstanone|Androstanolonum|17beta-Hydroxy-5alpha-Androstan-3-One|17β-hydroxy-5α-androstan-3-one|Androstanolona|5α-DHT|5-alpha Dihydrotestosterone|5alpha,17beta-Hydroxyandrostan-3-one
Dihydrotestosterone
C0006931
An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.
Capsaicin (substance)|Capsaicina|N-(4-hydroxy-3-methoxyphenylmethyl) -8-Methyl-6-Nonenamide|CAPSAICIN|8-Methyl-N-Vanillyl-6-Nonenamide|Isodecenoic acid vanillylamide|Product containing capsaicin (medicinal product)|Capsaicin|Capsaicine|(E)-N-[(4-hydroxy-3-methoxy-phenyl)methyl]-8-methyl-non-6-enamide|capsaicine|8 Methyl N Vanillyl 6 Nonenamide|6-Nonenamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-, (E)-|(E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide|Capsaicin-containing product|trans-8-Methyl-N-vanillyl-6-nonenamide|capsaicin|(E)-8-Methyl-N-vanillyl-6-nonenamide
capsaicin
C0041362
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Cultured Neoplastic Cells|Tumor Cell, Cultured|Neoplastic Cells, Cultured|Cells, Cultured Tumor|Cell, Cultured Neoplastic|Neoplastic Cell, Cultured|Cell, Cultured Tumor|Cultured Tumor Cell|Cultured Tumor Cells|Cells, Cultured Neoplastic|Cultured Neoplastic Cell
Tumor Cells, Cultured
C1333929
Herpes simplex virus thymidine kinase (HSV-Tk) gene encodes thymidine kinase protein, which is important for herpes simplex virus infection. The TK gene and promoter are widely used in genetic research because of the easily selectable phenotype.
Herpes Simplex Virus Thymidine Kinase Gene|HSV-Tk
HSV-Tk Gene
C0011503
A nucleoside consisting of the base guanine and the sugar deoxyribose.
Deoxyguanosine|Guanosine, 2'-deoxy-|Deoxyguanosine (substance)|2'-deoxyguanosine|deoxyguanosine
Deoxyguanosine
C1530869
null
4-oxo-4-HPR|4-oxo-fenretinide
4-oxofenretinide
C0060197
A synthetic retinoid that is used orally as a chemopreventive against prostate cancer and in women at risk of developing contralateral breast cancer. It is also effective as an antineoplastic agent.
4-hydroxy(phenyl)retinamide|N-(4-hydroxyphenyl)all-trans retinamide|All-trans-4'-Hydroxyretinanilide|FENRETINIDE|All-trans-4'-hydroxyretinanilide|all-trans-4'-hydroxyretinanilide|Retinamide, N-(4-hydroxyphenyl)-|Fenretinimide|N-(4-hydroxyphenyl)retinamide|all-trans-N-4'-hydroxyretinanilide|4-hpr|4HPR|4-HPR|fenretinimide|Fenretinidum|N-(4-Hydroxyphenyl)retinamide|Fenretinide|4-Hydroxyphenylretinamide|all-trans-N-(4-Hydroxyphenyl)retinamide|4-hydroxyphenylretinamide|Fenretinida|4-hydroxyphenyl retinamide|all-trans-N-(4-hydroxyphenyl)retinamide|fenretinide|HPR-4|4 Hydroxyphenylretinamide|N-(4-Hydroxyphenyl)-trans-Retinamide|4-(all-trans-retino-yl)aminophenol
Fenretinide
C1333250
This gene is involved in the regulation of dopamine receptor transport and neuronal signal transduction pertaining to neuronal growth and development.
DRD1|DRD1A|DOPAMINE RECEPTOR D1|DOPAMINE RECEPTOR D1A|dopamine receptor D1|DRD1 gene|Dopamine Receptor D1 Gene|DRD1 Gene
DRD1 gene
C1333250
This gene is involved in the regulation of dopamine receptor transport and neuronal signal transduction pertaining to neuronal growth and development.
DRD1|DRD1A|DOPAMINE RECEPTOR D1|DOPAMINE RECEPTOR D1A|dopamine receptor D1|DRD1 gene|Dopamine Receptor D1 Gene|DRD1 Gene
DRD1 gene
C0283779
An enzyme which catalyzes the hydrolysis of diphosphate (DIPHOSPHATES) into inorganic phosphate. The hydrolysis of pyrophosphate is coupled to the transport of HYDROGEN IONS across a membrane.
Pyrophosphate Energized Inorganic Pyrophosphatase|Inorganic Pyrophosphatase|Proton Translocating Pyrophosphatase|Proton-Translocating Pyrophosphatase|Proton Pumping Inorganic Pyrophosphatase|Pyrophosphatase, Proton-Pumping Inorganic|Inorganic pyrophosphatase|H+-Pyrophosphatase|Pyrophosphate-Energized Inorganic Pyrophosphatase|Pyrophosphatase, Pyrophosphate-Energized Inorganic|H+ Pyrophosphatase|H(+)-PPase|Pyrophosphatase, Proton-Translocating|Inorganic Pyrophosphatase, Proton-Pumping|Proton-Pumping Inorganic Pyrophosphatase|Inorganic Pyrophosphatase, Pyrophosphate-Energized|Pyrophosphatase, Inorganic|Inorganic pyrophosphatase (substance)
proton-translocating pyrophosphatase
C0814830
null
null
perspectives in epidemiology
C0814830
null
null
perspectives in epidemiology
C1137001
null
null
lbgB protein, H ducreyi
C1137001
null
null
lbgB protein, H ducreyi
C1334869
This gene is involved in regulation of transcription.
bA465L10.6|nuclear receptor coactivator 5|NCOA5 gene|CIA|NCOA5 Gene|coactivator independent of AF-2|NCOA5|Nuclear Receptor Coactivator 5 Gene|NUCLEAR RECEPTOR COACTIVATOR 5|COACTIVATOR INDEPENDENT OF AF2
NCOA5 gene
C1334869
This gene is involved in regulation of transcription.
bA465L10.6|nuclear receptor coactivator 5|NCOA5 gene|CIA|NCOA5 Gene|coactivator independent of AF-2|NCOA5|Nuclear Receptor Coactivator 5 Gene|NUCLEAR RECEPTOR COACTIVATOR 5|COACTIVATOR INDEPENDENT OF AF2
NCOA5 gene
C0672663
A substance being studied in the treatment of bladder cancer, lung cancer, and other types of cancer.
Vinflunine|Vinfluninum|Vinflunine (substance)|4'-deoxy-20',20'-difluoro-5'-norvincaleukoblastine|vinflunine|VINFLUNINE|Vinflunina|4'-deoxy-20',20'-difluoro-8'-norvincaleukoblastine|20',20'-difluoro-3',4'-dihydrovinorelbine|4'-Deoxy-20',20'-difluoro-C'-norvincaleukoblastine
vinflunine
C0596087
Agents and endogenous substances that antagonize or inhibit the development of new blood vessels.
Agents, Angiostatic|Angiogenic Antagonists|Substance with angiogenesis inhibitor mechanism of action (substance)|Angiogenesis Antagonists|Angiogenetic Antagonists|Angiogenetic Inhibitors|angiogenesis inhibitor|Antiangiogenic Agent|angiogenetic inhibitor|Neovascularization inhibitors|angiogenic inhibitors|Anti-Angiogenetic Agents|Antagonists, Angiogenic|Angiogenesis Inhibitors|Anti Angiogenetic Agents|anti angiogenic drug|Anti Angiogenic Drugs|Antiangiogenic Agents|Anti-Angiogenic Agents|Inhibitors, Neovascularization|Agents, Antiangiogenic|Angiostatic Agents|neovascularization inhibitors|Angiogenesis inhibitor-containing product|Neovascularization Inhibitors|Inhibitors, Angiogenetic|angiogenesis inhibitors|Inhibitors, Angiogenesis|Angiogenesis inhibitor|Angiogenesis Inhibitor|anti-angiogenic drugs|Anti-Angiogenic Drugs|Product containing angiogenesis inhibitor (product)|Agents, Anti-Angiogenetic|Angiogenic Inhibitors|Antiangiogenesis Agents|Substance with angiogenesis inhibitor mechanism of action|Angiogenesis Blockers|Drugs, Anti-Angiogenic|Antagonists, Angiogenetic|antiangiogenic|Inhibitors, Angiogenic|antiangiogenic agents
Angiogenesis Inhibitors
C0663446
A transcriptional elongation factor complex that is comprised of a heterodimer of CYCLIN-DEPENDENT KINASE 9 and one of several CYCLINS including TYPE T CYCLINS and cyclin K. It functions by phosphorylating the carboxy-terminal domain of RNA POLYMERASE II.
P-TEFb|Positive Transcriptional Elongation Factor B|Positive Transcription Elongation Factor B|tat Associated Kinase|tat-Associated Kinase
Positive Transcriptional Elongation Factor B
C0001857
A prodromal phase of infection with the human immunodeficiency virus (HIV). Laboratory criteria separating AIDS-related complex (ARC) from AIDS include elevated or hyperactive B-cell humoral immune responses, compared to depressed or normal antibody reactivity in AIDS; follicular or mixed hyperplasia in ARC lymph nodes, leading to lymphocyte degeneration and depletion more typical of AIDS; evolving succession of histopathological lesions such as localization of Kaposi's sarcoma, signaling the transition to the full-blown AIDS.
Complex, AIDS-Related|Lymphadenopathy Syndromes|aids-related complex (ARC)|Lymphadenopathy Syndrome|aids-related complex|AIDS Related Complex|AIDS RELATED COMPLEX|AIDS-related complex|ARC|AIDS-Related Complex|Syndromes, Lymphadenopathy|AIDS related complex|AIDS-like syndrome|Syndrome, Lymphadenopathy
AIDS related complex
C0073020
A broad category of enzymes that are involved in the process of GENETIC RECOMBINATION.
Recombinase|recombinases|recombinase|Recombinases
recombinase
C1533651
null
Cell-mediated immune deficiency|Deficiency of cell mediated immunity|Cellular immune defect|Deficiency of cell-mediated immunity|Cellular immune defect (finding)
Deficiency of cell-mediated immunity
C1155099
The chemical reactions and pathways resulting in the formation of cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. [GOC:bf, ISBN:0198506732, ISBN:0198599471]
cytokine biosynthetic process|cytokine anabolism|cytokine formation|cytokine biosynthesis|cytokine synthesis
cytokine biosynthesis
C0019733
A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*02 allele family.
Human leukocyte antigen A2|hla a2|HLA-A2|HLA - Human leucocyte antigen A2|HLA - Human leukocyte antigen A2|HLA-A2 antigen|Human leucocyte antigen A2|Human leukocyte antigen A2 (substance)|HLA-A2 Antigen|HLA A2 Antigen|hla-a2|Antigen, HLA-A2|HL-A2 antigen
HLA-A2 Antigen
C0812673
null
null
IMPLANT SUPPORTED RETAINER FOR CAST METAL FPD (TITANIUM, TITANIUM ALLOY, OR HIGH NOBLE METAL)
C0812673
null
null
IMPLANT SUPPORTED RETAINER FOR CAST METAL FPD (TITANIUM, TITANIUM ALLOY, OR HIGH NOBLE METAL)
C0599934
A vaccine based on a synthetic peptide or peptides produced from tissue samples or recombinant sources. Vaccination with peptide vaccines may elicit host immune responses against antigen-expressing cells.
peptide vaccine|Peptide Vaccines|Peptide Vaccine
Vaccines, Peptide
C0002976
group of agents that induce or stimulate the physiologic angiogenesis process.
angiogenesis factor|Factor, Angiogenic|Factor, Angiogenesis|Angiogenic Factor
Angiogenesis Factor
C0069141
Nucleophosmin (294 aa, ~33 kDa) is encoded by the human NPM1 gene. This protein is involved in ribosomal function.
nucleolar protein B23|Nucleolar Phosphoprotein B23|Nucleophosmin|NPM1|nucleophosmid|Numatrin|numatrin|protein B23|B23 Nuclear Matrix Protein|nucleolar phosphoprotein B23|nucleophosmin|phosphoprotein B23, nucleolus
nucleophosmin
C0024885
Removal of only enough breast tissue to ensure that the margins of the resected surgical specimen are free of tumor.
Mastectomy, Segmental|Segmental Mastectomy|segmentectomy|Segmentectomy|Mastectomies, Local Excision|Segmental Mastectomies|Segmental resection of breast|Mastectomies, Segmental|Partial mastectomy|Breast conserving therapy|Local Excision Mastectomies|Partial mastectomy (procedure)|Segmentectomies|Partial Mastectomies|Local Excision Mastectomy|Segmentectomy of breast|Partial Mastectomy|Mastectomies, Partial|Segmental excision of breast|Segmentectomy of breast (procedure)|Excision of part of breast|Mastectomy, Partial|Mastectomy, Local Excision|segmental mastectomy|Limited Resection Mastectomy|PARTIAL MASTECTOMY|mastectomy partial|Mastectomy, Limited Resection|mastectomy segmental|Subtotal mastectomy|Partial mastectomy, NOS|Mastectomies, Limited Resection|Limited Resection Mastectomies|Breast conservation therapy|partial mastectomy
Segmental Mastectomy
C0037815
Analysis of the intensity of Raman scattering of monochromatic light as a function of frequency of the scattered light.
Analysis, Raman Spectrum|Raman spectroscopy|Spectroscopy, IR/UV/Raman|Raman Spectroscopy|Spectroscopy, Raman|Raman spectrometry|raman spectroscopy|Raman Spectrum Analysis
Spectrum Analysis, Raman
C0184913
A surgical procedure to remove the remaining abnormal tissues from the body, not completely removed in an earlier attempt.
Re-Excision|Reexcision (procedure)|Re-excision|Reexcision|Reexcision, NOS|reexcision|re-excision
Reexcision
C1335965
A poorly cohesive gastric adenocarcinoma characterized by malignant cells containing intracytoplasmic mucin.
Signet Ring Cell Adenocarcinoma of Stomach|Signet Ring Cell Gastric Adenocarcinoma|Signet Ring Cell Adenocarcinoma of the Stomach|Signet Ring Cell Stomach Adenocarcinoma|Poorly cohesive carcinoma, including signet ring cell carcinoma
Gastric Signet Ring Cell Adenocarcinoma
C1335965
A poorly cohesive gastric adenocarcinoma characterized by malignant cells containing intracytoplasmic mucin.
Signet Ring Cell Adenocarcinoma of Stomach|Signet Ring Cell Gastric Adenocarcinoma|Signet Ring Cell Adenocarcinoma of the Stomach|Signet Ring Cell Stomach Adenocarcinoma|Poorly cohesive carcinoma, including signet ring cell carcinoma
Gastric Signet Ring Cell Adenocarcinoma
C1418438
null
PDHA2|PDHA2 gene|pyruvate dehydrogenase E1 alpha 2 subunit|PYRUVATE DEHYDROGENASE, ALPHA-2|PYRUVATE DEHYDROGENASE, E1-ALPHA POLYPEPTIDE, TESTIS-SPECIFIC
PDHA2 gene
C1418438
null
PDHA2|PDHA2 gene|pyruvate dehydrogenase E1 alpha 2 subunit|PYRUVATE DEHYDROGENASE, ALPHA-2|PYRUVATE DEHYDROGENASE, E1-ALPHA POLYPEPTIDE, TESTIS-SPECIFIC
PDHA2 gene
C1536991
null
antigen specificity
antigen specificity
C0073243
An RNA-containing enzyme that plays an essential role in tRNA processing by catalyzing the endonucleolytic cleavage of TRANSFER RNA precursors. It removes the extra 5'-nucleotides from tRNA precursors to generate mature tRNA molecules.
ribonuclease P|Ribonuclease P (substance)|RNase P|Ribonuclease P
RNase P
C0165198
null
ribonuclease MRP|RNAse MRP
RNAse MRP
C0014241
A family of enzymes that catalyze the endonucleolytic cleavage of RNA. It includes EC 3.1.26.-, EC 3.1.27.-, EC 3.1.30.-, and EC 3.1.31.-.
endoribonuclease|Endoribonuclease|rnase|Endoribonuclease (substance)|RNase|Endoribonucleases
Endoribonucleases
C0026661
A primary RNA transcript synthesized from a DNA template in eukaryotic nuclei which is post-transcriptionally modified and spliced to produce a mature mRNA.
Precursor, mRNA|Pre mRNA|mRNA Precursor|precursor mRNA|Precursor mRNA|pre mRNA|premRNA|Pre-mRNA|pre-mRNA|RNA, Messenger, Precursors
mRNA Precursor
C0678935
null
null
RNA translation
C0162771
Organelles in which the splicing and excision reactions that remove introns from precursor messenger RNA molecules occur. One component of a spliceosome is five small nuclear RNA molecules (U1, U2, U4, U5, U6) that, working in conjunction with proteins, help to fold pieces of RNA into the right shapes and later splice them into the message.
Spliceosome|spliceosome complex|spliceosome|spliceosome complex location|spliceosomal complex|Spliceosomes|spliceosomal complex location
Spliceosomes
C0184643
Actions taken to promote emotional well-being
care health mental|care mental health|Mental health care (regime/therapy)|Mental Health Care|Mental health care type elements|mental health care
Mental health care
C0557555
null
Clinical Psychotherapist|Psychotherapist, Clinical|psychotherapists|Psychotherapist|psychotherapist|Psychotherapists|Psychotherapists, Clinical|Clinical Psychotherapists|Psychotherapist (occupation)
Psychotherapists
C0009079
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Product containing clozapine (medicinal product)|5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-|CLOZAPINE|Clozapinum|CLOZAPINE (SANDOZ)|CLOZAPINE (GOLDEN STATE)|Clozapin|Clozapine (substance)|8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine|Clozapine|CLOZAPINE (MAYNE)|Clozapine-containing product|clozapine|Clozapina|cloZAPine
clozapine
C0679646
Someone who takes part in an activity.
participants|participant|Participant
Participant
C1269026
null
Entire pulmonary artery|Entire pulmonary artery (body structure)|Entire PA - Pulmonary artery
Entire pulmonary artery
C0238703
Individuals who have developed skills, physical stamina and strength or participants in SPORTS or other physical activities.
Athlete|athlete|Athletes|athletes|ATHLETE
Athletes
C0220854
abnormal increase in the depth and rate of respiratory movements.
Hyperpneic|Hyperpnea|Hyperpnoea|hyperpnoea|hyperpnea|Overbreathing|Hyperpnea (finding)|overbreathing|HYPERPNEA|Polypnea
Hyperpnea
C0427008
null
Stiffness|stiffness|'Stiffness'|Stiffness (finding)
Stiffness
C0909825
A ubiquitously-expressed claudin subtype that acts as a general barrier-forming protein in TIGHT JUNCTIONS. Elevated expression of claudin-3 is found in a variety of tumor cell types, suggesting its role as a therapeutic target for specific ANTINEOPLASTIC AGENTS.
Claudin-3|Claudin 3
claudin 3
C0040085
An enzyme of the transferase class that catalyzes the reaction 5,10-methylenetetrahydrofolate and dUMP to dihydrofolate and dTMP in the synthesis of thymidine triphosphate. (From Dorland, 27th ed) EC 2.1.1.45.
Thymidylate Synthase|Synthase, Thymidylate|Thymidylate synthase|thymidylate synthase|Synthetase, Thymidylate|5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase|EC 2.1.1.45|TMP synthetase|TYMS|Thymidylate Synthetase|dTMP Synthase|synthase thymidylate|Thymidylate synthase (substance)|thymidylate synthetase
Thymidylate Synthase
C1319315
The most common type of colorectal carcinoma. It is characterized by the presence of malignant glandular epithelial cells invading through the muscularis mucosa into the submucosa. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma.
Colorectal Adenocarcinoma|Adenocarcinoma of Large Bowel|Adenocarcinoma of the Large Intestine|colorectal adenocarcinoma|Adenocarcinoma of Large Intestine|Large Bowel Adenocarcinoma|Colorectal (Colon or Rectal) Adenocarcinoma|Adenocarcinoma of the large intestine|Adenocarcinoma of the Large Bowel|Large Intestine Adenocarcinoma|Adenocarcinoma of large intestine (disorder)|adenocarcinomas colorectal
Adenocarcinoma of large intestine
C1519521
Tissue that is not frozen or embedded in preservatives
Tissue, Fresh
Fresh Tissue
C1519524
Tissue that is preserved and embedded in paraffin.
Paraffin Block|Tissue, Paraffin|PARAFFIN-EMBEDDED|Paraffin-Embedded Specimen
Paraffin Embedded Tissue
C0027758
A family of highly acidic calcium-binding proteins found in large concentration in the brain and believed to be glial in origin. They are also found in other organs in the body. They have in common the EF-hand motif (EF HAND MOTIFS) found on a number of calcium binding proteins. The name of this family derives from the property of being soluble in a 100% saturated ammonium sulfate solution.
S100 Protein Family|S100 Calcium Binding Protein|protein s-100|S100 Protein|s-100 protein|s100 protein|S-100 Protein|S 100 Protein|Antigen S 100|Nerve Tissue Protein S 100|s 100 protein
S100 Proteins
C0073815
A modified form of acetylcysteine that is a metabolite of acrolein and may be found in the urine of smokers.
2-acetamido-3-(3'-hydroxypropylthio)propanoic acid|N-acetyl-S-(3-hydroxypropyl)-L-cysteine|N-acetyl-S-(3-hydroxypropyl)cysteine|S-(3-hydroxypropyl)cysteine N-acetate|1-(N-Acetylcysteinyl)-Propan-3-Ol|3-Hydroxypropyl Mercapturic Acid|HPMA|3-hydroxypropylmercapturic acid|3-Hydroxypropylmercapturic Acid
S-(3-hydroxypropyl)cysteine N-acetate
C0073815
A modified form of acetylcysteine that is a metabolite of acrolein and may be found in the urine of smokers.
2-acetamido-3-(3'-hydroxypropylthio)propanoic acid|N-acetyl-S-(3-hydroxypropyl)-L-cysteine|N-acetyl-S-(3-hydroxypropyl)cysteine|S-(3-hydroxypropyl)cysteine N-acetate|1-(N-Acetylcysteinyl)-Propan-3-Ol|3-Hydroxypropyl Mercapturic Acid|HPMA|3-hydroxypropylmercapturic acid|3-Hydroxypropylmercapturic Acid
S-(3-hydroxypropyl)cysteine N-acetate
C1332947
An anaplastic astrocytoma that arises from the brain and occurs during childhood.
Anaplastic Childhood Brain Astrocytoma|Grade III Pediatric Astrocytic Tumor of Brain|Grade III Childhood Astrocytoma of the Brain|Grade III Pediatric Brain Astrocytic Neoplasm|Grade III Pediatric Astrocytic Neoplasm of the Brain|Grade III Pediatric Brain Astrocytoma|Grade III Pediatric Astrocytoma of Brain|Grade III Pediatric Astrocytoma of the Brain|Grade III Childhood Astrocytic Tumor of the Brain|Anaplastic Pediatric Astrocytoma of the Brain|Grade III Pediatric Brain Astrocytic Tumor|Grade III Childhood Brain Astrocytoma|Grade III Childhood Brain Astrocytic Neoplasm|Anaplastic Childhood Astrocytoma of the Brain|Anaplastic Pediatric Brain Astrocytoma|Grade III Childhood Astrocytic Neoplasm of Brain|Grade III Childhood Astrocytic Neoplasm of the Brain|Anaplastic Pediatric Astrocytoma of Brain|Grade III Pediatric Astrocytic Tumor of the Brain|Grade III Childhood Brain Astrocytic Tumor|Anaplastic Childhood Astrocytoma of Brain|Grade III Pediatric Astrocytic Neoplasm of Brain|Grade III Childhood Astrocytic Tumor of Brain|Grade III Childhood Astrocytoma of Brain
Childhood Brain Anaplastic Astrocytoma
C1332947
An anaplastic astrocytoma that arises from the brain and occurs during childhood.
Anaplastic Childhood Brain Astrocytoma|Grade III Pediatric Astrocytic Tumor of Brain|Grade III Childhood Astrocytoma of the Brain|Grade III Pediatric Brain Astrocytic Neoplasm|Grade III Pediatric Astrocytic Neoplasm of the Brain|Grade III Pediatric Brain Astrocytoma|Grade III Pediatric Astrocytoma of Brain|Grade III Pediatric Astrocytoma of the Brain|Grade III Childhood Astrocytic Tumor of the Brain|Anaplastic Pediatric Astrocytoma of the Brain|Grade III Pediatric Brain Astrocytic Tumor|Grade III Childhood Brain Astrocytoma|Grade III Childhood Brain Astrocytic Neoplasm|Anaplastic Childhood Astrocytoma of the Brain|Anaplastic Pediatric Brain Astrocytoma|Grade III Childhood Astrocytic Neoplasm of Brain|Grade III Childhood Astrocytic Neoplasm of the Brain|Anaplastic Pediatric Astrocytoma of Brain|Grade III Pediatric Astrocytic Tumor of the Brain|Grade III Childhood Brain Astrocytic Tumor|Anaplastic Childhood Astrocytoma of Brain|Grade III Pediatric Astrocytic Neoplasm of Brain|Grade III Childhood Astrocytic Tumor of Brain|Grade III Childhood Astrocytoma of Brain
Childhood Brain Anaplastic Astrocytoma
C0334866
Physicians who assess changes in cellular or tissue structure and function to diagnose disease processes.
Medical pathologist (occupation)|PATHOLOGIST|Pathologist|Medical pathologist|medical pathologist|Pathologists|pathologist|pathologists
Medical pathologist
C0920288
This gene plays a role in cellular hematopoiesis and differentiations. Mutations in the gene are associated with several diseases, including acute myelogenous leukemia, gastrointestinal tumors, and mast cell disease.
V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog Gene|KIT Gene|KIT
C-KIT Gene
C0238546
null
ABDOMINAL MASS, UPPER
upper abdominal mass
C0080113
Product of the retinoblastoma tumor suppressor gene. It is a nuclear phosphoprotein hypothesized to normally act as an inhibitor of cell proliferation. Rb protein is absent in retinoblastoma cell lines. It also has been shown to form complexes with the adenovirus E1A protein, the SV40 T antigen, and the human papilloma virus E7 protein.
pRb|retinoblastoma protein (pRb)|Rb|Rb Protein|PP110|Rb Gene Product|Rb1 Gene Product|Retinoblastoma Protein|pRB|p105-Rb|prb|P105-RB|Retinoblastoma Associated Protein|RB1|RB Protein|Retinoblastoma-Associated Protein|retinoblastoma protein|pp110
Retinoblastoma Protein
C1522495
First lymph node to receive drainage from the primary tumor. SENTINEL LYMPH NODE BIOPSY is performed to determine early METASTASIS status because cancer cells may appear first in the sentinel node.
Sentinal Nodes|SLN|Lymph Node, Sentinel|Sentinel Lymph Nodes|Sentinel Node|Node, Sentinal|sentinel lymph node|Sentinel Lymph Node|Lymph Nodes, Sentinel|Sentinal Node|Nodes, Sentinal
Sentinel Lymph Node
C0030415
A mixture of solid hydrocarbons obtained from petroleum. It has a wide range of uses including as a stiffening agent in ointments, as a lubricant, and as a topical anti-inflammatory. It is also commonly used as an embedding material in histology.
Paraffins|PARAFFIN WAX|Paraffin wax-containing product|Paraffin wax (substance)|Hard paraffin|Paraffin wax|Paraffin, NOS|Product containing paraffin (medicinal product)|Product containing paraffin wax (medicinal product)|paraffin|Paraffin-containing product|PARAFFIN|PARAFFIN HYDROCARBONS|Paraffin (substance)|paraffin wax|Paraffin
paraffin
C0205645
An infiltrating adenocarcinoma in which the malignant cells form tubular structures. Representative examples include the tubular breast carcinoma and the gastric tubular adenocarcinoma.
Tubular Adenocarcinoma|Carcinomas, Tubular|tubular adenocarcinoma|Tubular Carcinoma|tubular carcinomas|Tubular Carcinomas|carcinoma tubular|Tubular carcinoma|Adenocarcinomas, Tubular|Adenocarcinoma, Tubular|Tubular Adenocarcinomas|Tubular adenocarcinoma|tubular carcinoma|Carcinoma, Tubular|CARCINOMA, TUBULAR CELL, MALIGNANT|Tubular adenocarcinoma (morphologic abnormality)
Adenocarcinoma, Tubular
C0054541
A family of actin and calcium binding proteins found mostly in smooth muscle-containing tissues. These proteins play a role in the regulation of actin/myosin interactions and the subsequent mediation of smooth muscle contraction.
Calponin|calponin
calponin
C0206704
A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)
Cell Carcinoma, Large|Carcinomas, Large Cell|Large cell carcinoma|Cell Carcinomas, Large|Carcinoma, Large Cell|LARGE CELL CARCINOMA|Large cell carcinoma, NOS|Large cell carcinoma (morphologic abnormality)|large cell carcinoma|Large Cell Carcinomas|Large Cell Carcinoma
Carcinoma, Large Cell
C1517548
An epithelial cell which may release secretions to a free epithelial surface (exocrine) or to the circulatory system (endocrine).
Glandular Cell
Glandular cell
C0143146
An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens, resulting in their opsinization. It also stimulates MACROPHAGES to undergo PHAGOCYTOSIS of microorganisms. Surfactant protein A contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.
Pulmonary Surfactant-Associated Protein A|SP A Protein|Pulmonary Surfactant Associated Protein A|Surfactant Protein A|SP-A Protein
Pulmonary Surfactant-Associated Protein A