bigbio/gad · Datasets at Hugging Face

id stringlengths 1 4	document_id stringlengths 1 4	text stringlengths 42 538	labels list
100	100	The @DISEASE$ of @GENE$ C26304T is related with the susceptibility to radiation injury.	[ "0" ]
101	101	The promoter polymorphisms of @GENE$, investigated in this study, do not influence the severity of @DISEASE$ outcome by 5 years.	[ "0" ]
102	102	If confirmed by others, our results indicate that more intensive @DISEASE$ prophylaxis is needed for patients with at least one IL-2 G allele, possibly directed toward blunting early host cell production of @GENE$.	[ "1" ]
103	103	The de novo origin of an @GENE$ (Arg677ter) mutation in a patient with simplex @DISEASE$ suggests that this common autosomal dominant RP mutation can arise independently in the population and supports the hypothesis of a mutational hotspot in the RP1 gene.	[ "1" ]
104	104	We identified a polymorphism in the @GENE$ gene associated with @DISEASE$.	[ "0" ]
105	105	In this large, prospective study, we found little evidence that the two previously described polymorphisms in the CD14 and @GENE$ genes are associated with risks of future @DISEASE$.	[ "1" ]
106	106	These findings suggest that the @GENE$ polymorphisms may form a genetic susceptibility factor for @DISEASE$ in men.	[ "0" ]
107	107	This suggests that the VNTR of the 5'-flanking region of the @GENE$ gene influences blood pressure levels in obesity-associated @DISEASE$.	[ "1" ]
108	108	The Arg3500Gln @DISEASE$ in the apolipoprotein B gene, which is responsible for familial defective @GENE$ and is present in approximately 1 in 1000 persons in Denmark, causes severe hypercholesterolemia and increases the risk of ischemic heart disease.	[ "0" ]
109	109	The finding of @GENE$ germ-line mutation in all patients with familial @DISEASE$ suggests that genetic screening should be useful in our population to identify affected individuals within a kindred and allow early detection of MEN1-related tumours.	[ "1" ]
110	110	A broad protective effect of @GENE$ S180L against @DISEASE$ per se is not discernible.	[ "0" ]
111	111	These findings are consistent with our initial observation for @DISEASE$ and further support the hypothesis that @GENE$ genotype may influence individual susceptibility to the development of certain cancer.	[ "0" ]
112	112	The @GENE$ 3'UTR microsatellite is associated with @DISEASE$, and the most represented alleles in patients were accompanied by a more prolonged protein expression in activated lymphocytes from controls.	[ "1" ]
113	113	Although requiring replication in larger samples, these findings provide preliminary evidence that sequence variation in @GENE$ is associated with susceptibility to @DISEASE$, particularly in males.	[ "1" ]
114	114	These results suggest that @GENE$ may have a role in the repair of 8-OH-dG adducts in prostate tissue and hOGG1 Ser326Cys polymorphism is associated with @DISEASE$ risk.	[ "1" ]
115	115	our data indicate significant associations between @GENE$ haplotypes and @DISEASE$ risk but do not support a relation between ADIPOR2 variability and the disease.	[ "0" ]
116	116	The results of our study of Turkish prostate cancer patients suggest that mutation of the @GENE$ gene may be an important risk factor for @DISEASE$.	[ "1" ]
117	117	although we were unable to support an association between @GENE$ A61G and @DISEASE$, the AA genotype might play a disease-modifying role differentially according to gender.	[ "1" ]
118	118	VDR overexpression in @DISEASE$ is independently associated with @GENE$ and KRAS mutations.	[ "1" ]
119	119	@GENE$ polymorphisms apparently play no role in promoting hypertensive renal damage, and do not influence endothelial-mediated @DISEASE$ in never-treated men with essential hypertension.	[ "0" ]
120	120	These data represent an important negative finding and suggest that, while @GENE$ is implicated in rare Mendelian susceptibility to mycobacterial disease, the common variants studied here do not have a major influence on susceptibility to @DISEASE$ in The Gambian population.	[ "1" ]
121	121	The polymorphisms of @GENE$, ALDH2, and CYP2E1 were significantly different in Korean patients with @DISEASE$ and Korean control subjects without alcoholism, but ADH3 and OPRM1 did not differ between the two groups.	[ "0" ]
122	122	We provide evidence that variants of @GENE$, XRCC3, and ERCC4/XPF genes, particularly in combination, contribute to @DISEASE$ susceptibility.	[ "1" ]
123	123	The polymorphisms of these two loci on the @GENE$) gene are unlikely to contribute to the etiology of @DISEASE$ in the Korean population.	[ "0" ]
124	124	Our results suggest a potential protective role for @GENE$ in both VaD and @DISEASE$, whereas TNF-alpha may act as a risk factor only for VaD, and not for AD.	[ "0" ]
125	125	Our results indicate that genetic polymorphisms affecting knee @DISEASE$ vary between populations (Japanese versus Caucasian) and sexes and indicate a role for ASPN, COMP, @GENE$, and COL2A1 in Caucasians.	[ "1" ]
126	126	There are no statistically significant differences in the frequencies of the Rad52 mutations between the control group and sporadic ovarian cancer patients and between the control groups and familial breast/ovarian cancer patients, indicating that these two mutations of the @GENE$ do not play a major role in the initiation of sporadic @DISEASE$ and familial breast/ovarian cancer.	[ "1" ]
127	127	An element of the innate immune system (@GENE$) has profound effects upon modulating the acquired allergen-specific immunoglobulin responses among those with an inherited @DISEASE$ predisposition.	[ "0" ]
128	128	The authors emphasize the usefulness of tau protein level measurement and determination of @GENE$ allele in diagnosis of @DISEASE$.	[ "1" ]
129	129	The two @GENE$ polymorphisms were found to be associated with all five bone measures (L2L4 and femoral neck DXA as well as heel SOS, BUA and @DISEASE$ index) in the whole sample.	[ "0" ]
130	130	Our analysis of the entire coding region and three parts of the promoter of the @GENE$ gene failed to show an association between genetic polymorphisms and AAA, suggesting that variations in the MMP2 gene do not contribute to the development of @DISEASE$.	[ "1" ]
131	131	This @DISEASE$ provides further evidence supporting a role of @GENE$ amplitude reduction as an endophenotype for disinhibited psychopathology.	[ "0" ]
132	132	Our findings support the hypothesis of the pivotal role of the G glycoprotein @GENE$ pathway in the @DISEASE$ of RSV bronchiolitis and propose CX3CR1 as a potential therapeutic target.	[ "0" ]
133	133	Chinese individuals >or=50 years of age carrying the AG genotype of NFKBIA may be at an increased risk of developing @DISEASE$, and the GG genotype of @GENE$ may be considered as a prognostic factor for Swedish CRC patients.	[ "1" ]
134	134	The @GENE$ gene and Hemicentin-1 genes do not appear to be involved in a statistically significant fraction of @DISEASE$ AMD cases in the Japanese population.	[ "0" ]
135	135	Our findings suggest that the @GENE$ A2 allele is associated with hormone levels, and interacts with insulin levels and diet to affect breast density levels and potentially @DISEASE$ risk.	[ "1" ]
136	136	In conclusion, we suggest that the @GENE$ genotype of the Gly482Ser polymorphism of the PGC-1 gene should be considered as a risk factor for the development of @DISEASE$ in Caucasians.	[ "0" ]
137	137	Our findings suggest that interactions between moderate-high meat consumption and the @GENE$ gene A52C polymorphism may increase the risk of @DISEASE$.	[ "1" ]
138	138	This study suggested that G894T @DISEASE$ in @GENE$ gene might serve as a major risk factor to the pathogenesis of P-CHD in this study population.	[ "0" ]
139	139	These findings may reflect the interaction of @GENE$ with the underlying genetic and phenotypic complexity that characterizes both @DISEASE$ and normal cognition and brain development.	[ "1" ]
140	140	The results suggest that the polymorphic alleles of @GENE$ and IL-1Ra studied play little or no part in the susceptibility to @DISEASE$ among these patients with systemic vasculitis.	[ "0" ]
141	141	The @GENE$-159 SNP might not play a major role in the development of @DISEASE$ in German children.	[ "1" ]
142	142	The -2849 IL-10 promoter polymorphism is associated with autoantibody production and subsequent joint @GENE$ in @DISEASE$.	[ "0" ]
143	143	This study suggest that @GENE$-@DISEASE$ polymorphisms may contribute to the risk of pancreatic cancer in our study population.	[ "0" ]
144	144	These results suggest an association between the @GENE$) C242T polymorphism and vascular aging, which might be mediated by the increase of @DISEASE$.	[ "0" ]
145	145	Our data suggest that @GENE$ gene polymorphisms may play an important role in the @DISEASE$ of vessel stenosis in Korean population.	[ "0" ]
146	146	Therefore, @GENE$ is unlikely to play a major role in the @DISEASE$ of PD.	[ "0" ]
147	147	@GENE$ overexpression in @DISEASE$ is independently associated with PIK3CA and KRAS mutations.	[ "0" ]
148	148	The results of our study show that @GENE$ is positively associated with the CTLA-4 A/G genotype, similarly to T1DM, thus providing further supporting evidence of the @DISEASE$ origin of this form of diabetes mellitus of the adult.	[ "0" ]
149	149	Polymorphism of @GENE$ -819C/T SNP site is associated with susceptibility to @DISEASE$ in Chinese Han people; at least five haplotypes of IL-10 gene promoter (ATA, ACC, GCC, ATC and ACA) exist in Chinese Han people.	[ "1" ]
150	150	These findings indicate that @GENE$ exonic variants may contribute to the risk of @DISEASE$ in the Chinese population, and these variant genotypes may modulate the risk of lung cancer associated with smoking.	[ "1" ]
151	151	These findings indicate that the promoter polymorphism of @GENE$ is a genetic factor conferring predisposition to @DISEASE$, and that it contributes considerably to disease pathogenesis in patients that were SE negative.	[ "0" ]
152	152	There is no evidence that mutations in exon 17 of the @GENE$ gene are involved in the @DISEASE$ of human IBD.	[ "0" ]
153	153	This study suggests that the Asn allele in the @GENE$ gene may be related to a reduced risk of @DISEASE$ among postmenopausal women by increasing their blood SHBG levels.	[ "1" ]
154	154	allograft TNFbeta and @GENE$ gene polymorphisms may be useful markers to predict the severity of @DISEASE$ recurrence among HCV+ patients after liver transplantation.	[ "0" ]
155	155	Thus, our study suggested that apo C III is an independent risk factor for atherosclerotic @DISEASE$ in Chinese @GENE$ 2 diabetes.	[ "0" ]
156	156	C1014T SNP of @GENE$ does not appear to be associated with susceptibility to @DISEASE$ in Japanese patients.	[ "1" ]
157	157	The @GENE$ -55 C/T polymorphism was associated with a higher atherogenic profile and modified the risk for the development of @DISEASE$.	[ "1" ]
158	158	We conclude that the two polymorphisms in the @GENE$ gene studied are not a major factor contributing to @DISEASE$ in our population.	[ "1" ]
159	159	This is the first report that @GENE$, IL8, and PPARG genes are important in relation to @DISEASE$-related risk of sporadic CRC.	[ "0" ]
160	160	In the present case-control study, we found no evidence of an association between the Glu298Asp variant of the @GENE$ gene and @DISEASE$/MI among Taiwanese.	[ "1" ]
161	161	@GENE$ genotypes predicted both the severity of baseline @DISEASE$ and relative responsiveness to antipsychotic treatment.	[ "0" ]
162	162	The present study provides additional evidence that SNPs in the proximal promoter region of the @GENE$ gene contribute to the development of @DISEASE$.	[ "1" ]
163	163	The results reported in this study suggest that @GENE$ polymorphism is a genetic susceptibility factor involved in the carcinogenesis of @DISEASE$, and also that the analysis of the allelic profile of populations in different geographic locations may help to understand the incidence of cervical cancer worldwide.	[ "1" ]
164	164	@GENE$ polymorphism T1277C (tyrosine-402 --> histidine-402) is strongly associated with both dry and wet @DISEASE$ and points to a possible role for inflammation in the pathogenesis of AMD.	[ "1" ]
165	165	In @DISEASE$, the protective effect of @GENE$ wt/Delta 32 is more pronounced in early years of infection and appears to be abrogated by the SDF1-3'A genotype.	[ "0" ]
166	166	Our data support LBP-1c/CP2/@GENE$ as a candidate gene/risk factor for @DISEASE$ and provide justification for future studies to investigate the role of this gene in Alzheimer's disease.	[ "1" ]
167	167	These findings indicate that the @GENE$ gene may be a candidate for the genetic regulation of common age-related @DISEASE$ like osteoporosis and spondylosis, and we provide the first evidence suggesting that this gene may be involved in the etiology of human diseases.	[ "0" ]
168	168	The R121W mutation in @GENE$ is a predisposing factor for the development of @DISEASE$ in Okinawans.	[ "1" ]
169	169	the APE1 Asp148Glu polymorphism is highly predictive for @DISEASE$, and cumulative cigarette smoking modifies the associations between the @GENE$ Arg399Gln and the XPD Lys751Gln polymorphisms and lung cancer risk.	[ "0" ]
170	170	These results suggest that @GENE$ Asp148Glu and XRCC1 Arg399Gln polymorphisms might modify the risk of @DISEASE$ attributable to cigarette smoking exposure.	[ "1" ]
171	171	A frameshifting 2-@GENE$ pair insertion at codon 99 of the RPGR gene produced typical @DISEASE$ and carrier findings (but no tapetallike reflex) in this family.	[ "0" ]
172	172	Our findings suggest that the @GENE$ gene may be implicated in the susceptibility to spontaneous @DISEASE$ of methamphetamine psychosis and that, as an intracellular adapter protein, PICK1 may play a role in the pathophysiology of methamphetamine psychosis.	[ "0" ]
173	173	Mutations in the @GENE$ gene do not appear to account for the variability in expression of the common Jewish @DISEASE$ mutation.	[ "1" ]
174	174	In conclusion, these results suggest that the @GENE$ gene may contribute to the genetic susceptibility to @DISEASE$.	[ "1" ]
175	175	@GENE$ polymorphism is not a useful marker for predicting the susceptibility or severity to @DISEASE$ for Taiwanese.	[ "1" ]
176	176	Our results suggest that polymorphisms of the @GENE$ gene may play a role in the pathogenesis of @DISEASE$.	[ "1" ]
177	177	We conclude that @GENE$ is associated with both the development of @DISEASE$ and ABO incompatibility.	[ "0" ]
178	178	The current study suggests a possible role of SNPs rather than mutations in @GENE$ in POAG @DISEASE$ in the Indian population.	[ "0" ]
179	179	the evidence for an association between @GENE$ I1307K and @DISEASE$ is not compelling.	[ "1" ]
180	180	This study suggests that certain null @GENE$ and GSTT1 genotypes may be associated with an elevated risk of @DISEASE$ which may be modified by interaction of the two genetic polymorphisms and cigarette smoking.	[ "1" ]
181	181	Our findings are consistent with the notion that genetic variation in the @GENE$ neurotransmitter system contributes to the pathogenesis of @DISEASE$.	[ "1" ]
182	182	The AA genotype of HMOX1 reduced the incidence of @DISEASE$, possibly due to the high expression level of @GENE$.	[ "1" ]
183	183	We demonstrated that the @GENE$ Pro185Ala polymorphism contributed to a predisposition to male factor @DISEASE$ in the Estonian population.	[ "0" ]
184	184	We can speculate that susceptibility to the development of @DISEASE$ could be influenced by the 1704G/T polymorphism of the @GENE$ gene, independently of diabetes.	[ "0" ]
185	185	Mutations in exon 6 of @GENE$ existed in the patients with FAD and @DISEASE$, and the two missense mutations were probably pathological by nature.	[ "0" ]
186	186	These findings support the hypothesis that these two @GENE$ variants may contribute to the risk of developing @DISEASE$.	[ "1" ]
187	187	Together these data implicate that @GENE$ is the first really strong genetic factor identified in a common complex @DISEASE$.	[ "0" ]
188	188	The @GENE$ gene is likely to be involved in the genetic vulnerability for @DISEASE$.	[ "1" ]
189	189	Our results confirm the positive association between CHL1 gene and @DISEASE$ and indicate that @GENE$ may be involved in the etiology of schizophrenia.	[ "1" ]
190	190	Unlike previously reported positive association, in this population, there is no evidence that susceptibility to @DISEASE$ is associated with HLA-@GENE$.	[ "0" ]
191	191	The results of our study indicate that @DISEASE$ diseases are caused, in part, by impairment of the IL-12 signal cascade, which downregulates IgE production, and that the mutation of the @GENE$) chain gene is one of the causative genes for atopy.	[ "1" ]
192	192	Our findings suggest that in the H. pylori-infected southern European population, the cagA genotype and the @GENE$(*)0602 gene confer an increased risk for distal @DISEASE$.	[ "1" ]
193	193	The results indicated that @GENE$ G1649C and SP-A2 A1660G, polymorphisms in the collagen region of SP-A2, might be one of the contributing factors to genetic predisposition and severity of clinical markers of @DISEASE$.	[ "0" ]
194	194	This large case-control study argues for an only minor-if any-role of the @GENE$ and ECE-1 genotype for the risk of @DISEASE$ development.	[ "1" ]
195	195	All together, our results show that genome wide patterns of alteration differ between @GENE$ and KRAS @DISEASE$ lung ADC, describe two models of oncogenic cooperation involving either EGFR mutation and CDKN2A deletion or cyclin amplification and TP53 inactiva	[ "0" ]
196	196	These results suggest that the @GENE$ -463G>A polymorphism does not significantly affect the susceptibility to @DISEASE$ in Koreans.	[ "1" ]
197	197	Our results highlight the potential protective effect of @GENE$*06 alleles on the course of @DISEASE$.	[ "1" ]
198	198	These results suggest that the polymorphisms in the @GENE$ gene and the IL-4 receptor alpha chain gene play no role in the development of @DISEASE$ in patients who have normal IgE productivity.	[ "1" ]
199	199	The @GENE$ polymorphisms associated with rheumatoid arthritis in a Japanese population are not associated per se with @DISEASE$ in a Spanish population.	[ "1" ]

100

The @DISEASE$ of @GENE$ C26304T is related with the susceptibility to radiation injury.

[ "0" ]

101

The promoter polymorphisms of @GENE$, investigated in this study, do not influence the severity of @DISEASE$ outcome by 5 years.

[ "0" ]

102

If confirmed by others, our results indicate that more intensive @DISEASE$ prophylaxis is needed for patients with at least one IL-2 G allele, possibly directed toward blunting early host cell production of @GENE$.

[ "1" ]

103

The de novo origin of an @GENE$ (Arg677ter) mutation in a patient with simplex @DISEASE$ suggests that this common autosomal dominant RP mutation can arise independently in the population and supports the hypothesis of a mutational hotspot in the RP1 gene.

[ "1" ]

104

We identified a polymorphism in the @GENE$ gene associated with @DISEASE$.

[ "0" ]

105

In this large, prospective study, we found little evidence that the two previously described polymorphisms in the CD14 and @GENE$ genes are associated with risks of future @DISEASE$.

[ "1" ]

106

These findings suggest that the @GENE$ polymorphisms may form a genetic susceptibility factor for @DISEASE$ in men.

[ "0" ]

107

This suggests that the VNTR of the 5'-flanking region of the @GENE$ gene influences blood pressure levels in obesity-associated @DISEASE$.

[ "1" ]

108

The Arg3500Gln @DISEASE$ in the apolipoprotein B gene, which is responsible for familial defective @GENE$ and is present in approximately 1 in 1000 persons in Denmark, causes severe hypercholesterolemia and increases the risk of ischemic heart disease.

[ "0" ]

109

The finding of @GENE$ germ-line mutation in all patients with familial @DISEASE$ suggests that genetic screening should be useful in our population to identify affected individuals within a kindred and allow early detection of MEN1-related tumours.

[ "1" ]

110

A broad protective effect of @GENE$ S180L against @DISEASE$ per se is not discernible.

[ "0" ]

111

These findings are consistent with our initial observation for @DISEASE$ and further support the hypothesis that @GENE$ genotype may influence individual susceptibility to the development of certain cancer.

[ "0" ]

112

The @GENE$ 3'UTR microsatellite is associated with @DISEASE$, and the most represented alleles in patients were accompanied by a more prolonged protein expression in activated lymphocytes from controls.

[ "1" ]

113

Although requiring replication in larger samples, these findings provide preliminary evidence that sequence variation in @GENE$ is associated with susceptibility to @DISEASE$, particularly in males.

[ "1" ]

114

These results suggest that @GENE$ may have a role in the repair of 8-OH-dG adducts in prostate tissue and hOGG1 Ser326Cys polymorphism is associated with @DISEASE$ risk.

[ "1" ]

115

our data indicate significant associations between @GENE$ haplotypes and @DISEASE$ risk but do not support a relation between ADIPOR2 variability and the disease.

[ "0" ]

116

The results of our study of Turkish prostate cancer patients suggest that mutation of the @GENE$ gene may be an important risk factor for @DISEASE$.

[ "1" ]

117

although we were unable to support an association between @GENE$ A61G and @DISEASE$, the AA genotype might play a disease-modifying role differentially according to gender.

[ "1" ]

118

VDR overexpression in @DISEASE$ is independently associated with @GENE$ and KRAS mutations.

[ "1" ]

119

@GENE$ polymorphisms apparently play no role in promoting hypertensive renal damage, and do not influence endothelial-mediated @DISEASE$ in never-treated men with essential hypertension.

[ "0" ]

120

These data represent an important negative finding and suggest that, while @GENE$ is implicated in rare Mendelian susceptibility to mycobacterial disease, the common variants studied here do not have a major influence on susceptibility to @DISEASE$ in The Gambian population.

[ "1" ]

121

The polymorphisms of @GENE$, ALDH2, and CYP2E1 were significantly different in Korean patients with @DISEASE$ and Korean control subjects without alcoholism, but ADH3 and OPRM1 did not differ between the two groups.

[ "0" ]

122

We provide evidence that variants of @GENE$, XRCC3, and ERCC4/XPF genes, particularly in combination, contribute to @DISEASE$ susceptibility.

[ "1" ]

123

The polymorphisms of these two loci on the @GENE$) gene are unlikely to contribute to the etiology of @DISEASE$ in the Korean population.

[ "0" ]

124

Our results suggest a potential protective role for @GENE$ in both VaD and @DISEASE$, whereas TNF-alpha may act as a risk factor only for VaD, and not for AD.

[ "0" ]

125

Our results indicate that genetic polymorphisms affecting knee @DISEASE$ vary between populations (Japanese versus Caucasian) and sexes and indicate a role for ASPN, COMP, @GENE$, and COL2A1 in Caucasians.

[ "1" ]

126

There are no statistically significant differences in the frequencies of the Rad52 mutations between the control group and sporadic ovarian cancer patients and between the control groups and familial breast/ovarian cancer patients, indicating that these two mutations of the @GENE$ do not play a major role in the initiation of sporadic @DISEASE$ and familial breast/ovarian cancer.

[ "1" ]

127

An element of the innate immune system (@GENE$) has profound effects upon modulating the acquired allergen-specific immunoglobulin responses among those with an inherited @DISEASE$ predisposition.

[ "0" ]

128

The authors emphasize the usefulness of tau protein level measurement and determination of @GENE$ allele in diagnosis of @DISEASE$.

[ "1" ]

129

The two @GENE$ polymorphisms were found to be associated with all five bone measures (L2L4 and femoral neck DXA as well as heel SOS, BUA and @DISEASE$ index) in the whole sample.

[ "0" ]

130

Our analysis of the entire coding region and three parts of the promoter of the @GENE$ gene failed to show an association between genetic polymorphisms and AAA, suggesting that variations in the MMP2 gene do not contribute to the development of @DISEASE$.

[ "1" ]

131

This @DISEASE$ provides further evidence supporting a role of @GENE$ amplitude reduction as an endophenotype for disinhibited psychopathology.

[ "0" ]

132

Our findings support the hypothesis of the pivotal role of the G glycoprotein @GENE$ pathway in the @DISEASE$ of RSV bronchiolitis and propose CX3CR1 as a potential therapeutic target.

[ "0" ]

133

Chinese individuals >or=50 years of age carrying the AG genotype of NFKBIA may be at an increased risk of developing @DISEASE$, and the GG genotype of @GENE$ may be considered as a prognostic factor for Swedish CRC patients.

[ "1" ]

134

The @GENE$ gene and Hemicentin-1 genes do not appear to be involved in a statistically significant fraction of @DISEASE$ AMD cases in the Japanese population.

[ "0" ]

135

Our findings suggest that the @GENE$ A2 allele is associated with hormone levels, and interacts with insulin levels and diet to affect breast density levels and potentially @DISEASE$ risk.

[ "1" ]

136

In conclusion, we suggest that the @GENE$ genotype of the Gly482Ser polymorphism of the PGC-1 gene should be considered as a risk factor for the development of @DISEASE$ in Caucasians.

[ "0" ]

137

Our findings suggest that interactions between moderate-high meat consumption and the @GENE$ gene A52C polymorphism may increase the risk of @DISEASE$.

[ "1" ]

138

This study suggested that G894T @DISEASE$ in @GENE$ gene might serve as a major risk factor to the pathogenesis of P-CHD in this study population.

[ "0" ]

139

These findings may reflect the interaction of @GENE$ with the underlying genetic and phenotypic complexity that characterizes both @DISEASE$ and normal cognition and brain development.

[ "1" ]

140

The results suggest that the polymorphic alleles of @GENE$ and IL-1Ra studied play little or no part in the susceptibility to @DISEASE$ among these patients with systemic vasculitis.

[ "0" ]

141

The @GENE$-159 SNP might not play a major role in the development of @DISEASE$ in German children.

[ "1" ]

142

The -2849 IL-10 promoter polymorphism is associated with autoantibody production and subsequent joint @GENE$ in @DISEASE$.

[ "0" ]

143

This study suggest that @GENE$-@DISEASE$ polymorphisms may contribute to the risk of pancreatic cancer in our study population.

[ "0" ]

144

These results suggest an association between the @GENE$) C242T polymorphism and vascular aging, which might be mediated by the increase of @DISEASE$.

[ "0" ]

145

Our data suggest that @GENE$ gene polymorphisms may play an important role in the @DISEASE$ of vessel stenosis in Korean population.

[ "0" ]

146

Therefore, @GENE$ is unlikely to play a major role in the @DISEASE$ of PD.

[ "0" ]

147

@GENE$ overexpression in @DISEASE$ is independently associated with PIK3CA and KRAS mutations.

[ "0" ]

148

The results of our study show that @GENE$ is positively associated with the CTLA-4 A/G genotype, similarly to T1DM, thus providing further supporting evidence of the @DISEASE$ origin of this form of diabetes mellitus of the adult.

[ "0" ]

149

Polymorphism of @GENE$ -819C/T SNP site is associated with susceptibility to @DISEASE$ in Chinese Han people; at least five haplotypes of IL-10 gene promoter (ATA, ACC, GCC, ATC and ACA) exist in Chinese Han people.

[ "1" ]

150

These findings indicate that @GENE$ exonic variants may contribute to the risk of @DISEASE$ in the Chinese population, and these variant genotypes may modulate the risk of lung cancer associated with smoking.

[ "1" ]

151

These findings indicate that the promoter polymorphism of @GENE$ is a genetic factor conferring predisposition to @DISEASE$, and that it contributes considerably to disease pathogenesis in patients that were SE negative.

[ "0" ]

152

There is no evidence that mutations in exon 17 of the @GENE$ gene are involved in the @DISEASE$ of human IBD.

[ "0" ]

153

This study suggests that the Asn allele in the @GENE$ gene may be related to a reduced risk of @DISEASE$ among postmenopausal women by increasing their blood SHBG levels.

[ "1" ]

154

allograft TNFbeta and @GENE$ gene polymorphisms may be useful markers to predict the severity of @DISEASE$ recurrence among HCV+ patients after liver transplantation.

[ "0" ]

155

Thus, our study suggested that apo C III is an independent risk factor for atherosclerotic @DISEASE$ in Chinese @GENE$ 2 diabetes.

[ "0" ]

156

C1014T SNP of @GENE$ does not appear to be associated with susceptibility to @DISEASE$ in Japanese patients.

[ "1" ]

157

The @GENE$ -55 C/T polymorphism was associated with a higher atherogenic profile and modified the risk for the development of @DISEASE$.

[ "1" ]

158

We conclude that the two polymorphisms in the @GENE$ gene studied are not a major factor contributing to @DISEASE$ in our population.

[ "1" ]

159

This is the first report that @GENE$, IL8, and PPARG genes are important in relation to @DISEASE$-related risk of sporadic CRC.

[ "0" ]

160

In the present case-control study, we found no evidence of an association between the Glu298Asp variant of the @GENE$ gene and @DISEASE$/MI among Taiwanese.

[ "1" ]

161

@GENE$ genotypes predicted both the severity of baseline @DISEASE$ and relative responsiveness to antipsychotic treatment.

[ "0" ]

162

The present study provides additional evidence that SNPs in the proximal promoter region of the @GENE$ gene contribute to the development of @DISEASE$.

[ "1" ]

163

The results reported in this study suggest that @GENE$ polymorphism is a genetic susceptibility factor involved in the carcinogenesis of @DISEASE$, and also that the analysis of the allelic profile of populations in different geographic locations may help to understand the incidence of cervical cancer worldwide.

[ "1" ]

164

@GENE$ polymorphism T1277C (tyrosine-402 --> histidine-402) is strongly associated with both dry and wet @DISEASE$ and points to a possible role for inflammation in the pathogenesis of AMD.

[ "1" ]

165

In @DISEASE$, the protective effect of @GENE$ wt/Delta 32 is more pronounced in early years of infection and appears to be abrogated by the SDF1-3'A genotype.

[ "0" ]

166

Our data support LBP-1c/CP2/@GENE$ as a candidate gene/risk factor for @DISEASE$ and provide justification for future studies to investigate the role of this gene in Alzheimer's disease.

[ "1" ]

167

These findings indicate that the @GENE$ gene may be a candidate for the genetic regulation of common age-related @DISEASE$ like osteoporosis and spondylosis, and we provide the first evidence suggesting that this gene may be involved in the etiology of human diseases.

[ "0" ]

168

The R121W mutation in @GENE$ is a predisposing factor for the development of @DISEASE$ in Okinawans.

[ "1" ]

169

the APE1 Asp148Glu polymorphism is highly predictive for @DISEASE$, and cumulative cigarette smoking modifies the associations between the @GENE$ Arg399Gln and the XPD Lys751Gln polymorphisms and lung cancer risk.

[ "0" ]

170

These results suggest that @GENE$ Asp148Glu and XRCC1 Arg399Gln polymorphisms might modify the risk of @DISEASE$ attributable to cigarette smoking exposure.

[ "1" ]

171

A frameshifting 2-@GENE$ pair insertion at codon 99 of the RPGR gene produced typical @DISEASE$ and carrier findings (but no tapetallike reflex) in this family.

[ "0" ]

172

Our findings suggest that the @GENE$ gene may be implicated in the susceptibility to spontaneous @DISEASE$ of methamphetamine psychosis and that, as an intracellular adapter protein, PICK1 may play a role in the pathophysiology of methamphetamine psychosis.

[ "0" ]

173

Mutations in the @GENE$ gene do not appear to account for the variability in expression of the common Jewish @DISEASE$ mutation.

[ "1" ]

174

In conclusion, these results suggest that the @GENE$ gene may contribute to the genetic susceptibility to @DISEASE$.

[ "1" ]

175

@GENE$ polymorphism is not a useful marker for predicting the susceptibility or severity to @DISEASE$ for Taiwanese.

[ "1" ]

176

Our results suggest that polymorphisms of the @GENE$ gene may play a role in the pathogenesis of @DISEASE$.

[ "1" ]

177

We conclude that @GENE$ is associated with both the development of @DISEASE$ and ABO incompatibility.

[ "0" ]

178

The current study suggests a possible role of SNPs rather than mutations in @GENE$ in POAG @DISEASE$ in the Indian population.

[ "0" ]

179

the evidence for an association between @GENE$ I1307K and @DISEASE$ is not compelling.

[ "1" ]

180

This study suggests that certain null @GENE$ and GSTT1 genotypes may be associated with an elevated risk of @DISEASE$ which may be modified by interaction of the two genetic polymorphisms and cigarette smoking.

[ "1" ]

181

Our findings are consistent with the notion that genetic variation in the @GENE$ neurotransmitter system contributes to the pathogenesis of @DISEASE$.

[ "1" ]

182

The AA genotype of HMOX1 reduced the incidence of @DISEASE$, possibly due to the high expression level of @GENE$.

[ "1" ]

183

We demonstrated that the @GENE$ Pro185Ala polymorphism contributed to a predisposition to male factor @DISEASE$ in the Estonian population.

[ "0" ]

184

We can speculate that susceptibility to the development of @DISEASE$ could be influenced by the 1704G/T polymorphism of the @GENE$ gene, independently of diabetes.

[ "0" ]

185

Mutations in exon 6 of @GENE$ existed in the patients with FAD and @DISEASE$, and the two missense mutations were probably pathological by nature.

[ "0" ]

186

These findings support the hypothesis that these two @GENE$ variants may contribute to the risk of developing @DISEASE$.

[ "1" ]

187

Together these data implicate that @GENE$ is the first really strong genetic factor identified in a common complex @DISEASE$.

[ "0" ]

188

The @GENE$ gene is likely to be involved in the genetic vulnerability for @DISEASE$.

[ "1" ]

189

Our results confirm the positive association between CHL1 gene and @DISEASE$ and indicate that @GENE$ may be involved in the etiology of schizophrenia.

[ "1" ]

190

Unlike previously reported positive association, in this population, there is no evidence that susceptibility to @DISEASE$ is associated with HLA-@GENE$.

[ "0" ]

191

The results of our study indicate that @DISEASE$ diseases are caused, in part, by impairment of the IL-12 signal cascade, which downregulates IgE production, and that the mutation of the @GENE$) chain gene is one of the causative genes for atopy.

[ "1" ]

192

Our findings suggest that in the H. pylori-infected southern European population, the cagA genotype and the @GENE$(*)0602 gene confer an increased risk for distal @DISEASE$.

[ "1" ]

193

The results indicated that @GENE$ G1649C and SP-A2 A1660G, polymorphisms in the collagen region of SP-A2, might be one of the contributing factors to genetic predisposition and severity of clinical markers of @DISEASE$.

[ "0" ]

194

This large case-control study argues for an only minor-if any-role of the @GENE$ and ECE-1 genotype for the risk of @DISEASE$ development.

[ "1" ]

195

All together, our results show that genome wide patterns of alteration differ between @GENE$ and KRAS @DISEASE$ lung ADC, describe two models of oncogenic cooperation involving either EGFR mutation and CDKN2A deletion or cyclin amplification and TP53 inactiva

[ "0" ]

196

These results suggest that the @GENE$ -463G>A polymorphism does not significantly affect the susceptibility to @DISEASE$ in Koreans.

[ "1" ]

197

Our results highlight the potential protective effect of @GENE$*06 alleles on the course of @DISEASE$.

[ "1" ]

198

These results suggest that the polymorphisms in the @GENE$ gene and the IL-4 receptor alpha chain gene play no role in the development of @DISEASE$ in patients who have normal IgE productivity.

[ "1" ]

199

The @GENE$ polymorphisms associated with rheumatoid arthritis in a Japanese population are not associated per se with @DISEASE$ in a Spanish population.

[ "1" ]