id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_1200 | split_0_train_1200 | [
{
"id": "split_0_train_1200_passage",
"type": "progene_text",
"text": [
"The overall results demonstrate that 3 beta GSD and its 3 alpha isomeric alcohol specifically bind to the ER and possess a weak intrinsic oestrogenic activity , whereas unmodified GSD does not ."
],
"offsets": [
[
0,
194
]
]
}
]
| [
{
"id": "split_0_train_1736_entity",
"type": "progene_text",
"text": [
"ER"
],
"offsets": [
[
106,
108
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1201 | split_0_train_1201 | [
{
"id": "split_0_train_1201_passage",
"type": "progene_text",
"text": [
"The data contribute to a better understanding of the GSD mechanism of action and allow the hypothesis to be advanced that the slight oestrogenlike effects attributable to GSD are mediated by its non - phenolic , tetrahydro reduced metabolites ."
],
"offsets": [
[
0,
244
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1202 | split_0_train_1202 | [
{
"id": "split_0_train_1202_passage",
"type": "progene_text",
"text": [
"Molecular mechanism of ultraviolet - induced keratinocyte apoptosis ."
],
"offsets": [
[
0,
69
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1203 | split_0_train_1203 | [
{
"id": "split_0_train_1203_passage",
"type": "progene_text",
"text": [
"This article reviews advances in the study of the molecular mechanisms for ultraviolet ( UV ) - induced keratinocyte apoptosis , with particular reference to the cytokines tumor necrosis factor - alpha ( TNF-alpha ) and Fas ligand ( FasL ) ."
],
"offsets": [
[
0,
241
]
]
}
]
| [
{
"id": "split_0_train_1737_entity",
"type": "progene_text",
"text": [
"cytokines"
],
"offsets": [
[
162,
171
]
],
"normalized": []
},
{
"id": "split_0_train_1738_entity",
"type": "progene_text",
"text": [
"tumor necrosis factor - alpha"
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[
172,
201
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],
"normalized": []
},
{
"id": "split_0_train_1739_entity",
"type": "progene_text",
"text": [
"TNF-alpha"
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[
204,
213
]
],
"normalized": []
},
{
"id": "split_0_train_1740_entity",
"type": "progene_text",
"text": [
"Fas ligand"
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[
220,
230
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],
"normalized": []
},
{
"id": "split_0_train_1741_entity",
"type": "progene_text",
"text": [
"FasL"
],
"offsets": [
[
233,
237
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1204 | split_0_train_1204 | [
{
"id": "split_0_train_1204_passage",
"type": "progene_text",
"text": [
"TNF-alpha and FasL induce their respective receptors and then activate caspase enzymes that are critically involved in the apoptotic process ."
],
"offsets": [
[
0,
142
]
]
}
]
| [
{
"id": "split_0_train_1742_entity",
"type": "progene_text",
"text": [
"TNF-alpha"
],
"offsets": [
[
0,
9
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],
"normalized": []
},
{
"id": "split_0_train_1743_entity",
"type": "progene_text",
"text": [
"FasL"
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"offsets": [
[
14,
18
]
],
"normalized": []
},
{
"id": "split_0_train_1744_entity",
"type": "progene_text",
"text": [
"caspase"
],
"offsets": [
[
71,
78
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1205 | split_0_train_1205 | [
{
"id": "split_0_train_1205_passage",
"type": "progene_text",
"text": [
"This activation is further amplified by intracellular mitochondria - associated mechanisms ."
],
"offsets": [
[
0,
92
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1206 | split_0_train_1206 | [
{
"id": "split_0_train_1206_passage",
"type": "progene_text",
"text": [
"Using gene - targeted knockout mice lacking either the TNF - Rp55 or the TNF-Rp75 , we have shown that TNF-alpha plays an important role in UV - induced keratinocyte apoptosis via TNF-Rp55 ."
],
"offsets": [
[
0,
190
]
]
}
]
| [
{
"id": "split_0_train_1745_entity",
"type": "progene_text",
"text": [
"TNF - Rp55"
],
"offsets": [
[
55,
65
]
],
"normalized": []
},
{
"id": "split_0_train_1746_entity",
"type": "progene_text",
"text": [
"TNF-Rp75"
],
"offsets": [
[
73,
81
]
],
"normalized": []
},
{
"id": "split_0_train_1747_entity",
"type": "progene_text",
"text": [
"TNF-alpha"
],
"offsets": [
[
103,
112
]
],
"normalized": []
},
{
"id": "split_0_train_1748_entity",
"type": "progene_text",
"text": [
"TNF-Rp55"
],
"offsets": [
[
180,
188
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1207 | split_0_train_1207 | [
{
"id": "split_0_train_1207_passage",
"type": "progene_text",
"text": [
"TNF - Rp55 shares homology with Fas and contains an intracellular death domain ."
],
"offsets": [
[
0,
80
]
]
}
]
| [
{
"id": "split_0_train_1749_entity",
"type": "progene_text",
"text": [
"TNF - Rp55"
],
"offsets": [
[
0,
10
]
],
"normalized": []
},
{
"id": "split_0_train_1750_entity",
"type": "progene_text",
"text": [
"Fas"
],
"offsets": [
[
32,
35
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1208 | split_0_train_1208 | [
{
"id": "split_0_train_1208_passage",
"type": "progene_text",
"text": [
"UV seems to directly stimulate cross - linking of Fas , resulting in the engagement of the death machinery ."
],
"offsets": [
[
0,
108
]
]
}
]
| [
{
"id": "split_0_train_1751_entity",
"type": "progene_text",
"text": [
"Fas"
],
"offsets": [
[
50,
53
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1209 | split_0_train_1209 | [
{
"id": "split_0_train_1209_passage",
"type": "progene_text",
"text": [
"Fas - associated death domain protein ( FADD ) acts as an adapter protein in both the TNF - Rp55 and Fas death - inducing cascades and is responsible for downstream signal transduction by recruiting caspases ."
],
"offsets": [
[
0,
209
]
]
}
]
| [
{
"id": "split_0_train_1752_entity",
"type": "progene_text",
"text": [
"Fas - associated death domain protein"
],
"offsets": [
[
0,
37
]
],
"normalized": []
},
{
"id": "split_0_train_1753_entity",
"type": "progene_text",
"text": [
"FADD"
],
"offsets": [
[
40,
44
]
],
"normalized": []
},
{
"id": "split_0_train_1754_entity",
"type": "progene_text",
"text": [
"adapter protein"
],
"offsets": [
[
58,
73
]
],
"normalized": []
},
{
"id": "split_0_train_1755_entity",
"type": "progene_text",
"text": [
"TNF - Rp55"
],
"offsets": [
[
86,
96
]
],
"normalized": []
},
{
"id": "split_0_train_1756_entity",
"type": "progene_text",
"text": [
"Fas"
],
"offsets": [
[
101,
104
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1210 | split_0_train_1210 | [
{
"id": "split_0_train_1210_passage",
"type": "progene_text",
"text": [
"Moreover , signaling of p53 contributes to the induction of apoptosis by regulating Bcl-2 family expression and increasing surface Fas expression ."
],
"offsets": [
[
0,
147
]
]
}
]
| [
{
"id": "split_0_train_1757_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
24,
27
]
],
"normalized": []
},
{
"id": "split_0_train_1758_entity",
"type": "progene_text",
"text": [
"Bcl-2 family"
],
"offsets": [
[
84,
96
]
],
"normalized": []
},
{
"id": "split_0_train_1759_entity",
"type": "progene_text",
"text": [
"Fas"
],
"offsets": [
[
131,
134
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1211 | split_0_train_1211 | [
{
"id": "split_0_train_1211_passage",
"type": "progene_text",
"text": [
"In addition to induction mechanisms of apoptosis , there are numerous inhibitory molecules that play a role in restricting the apoptotic pathway ."
],
"offsets": [
[
0,
146
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1212 | split_0_train_1212 | [
{
"id": "split_0_train_1212_passage",
"type": "progene_text",
"text": [
"Thus , the ultimate determination of whether or not a cell undergoes apoptosis after UV radiation is based on the balance between agonist and antagonist pathways ."
],
"offsets": [
[
0,
163
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1213 | split_0_train_1213 | [
{
"id": "split_0_train_1213_passage",
"type": "progene_text",
"text": [
"Transformation of Arabidopsis with a Brassica SLG / SRK region and ARC1 gene is not sufficient to transfer the self - incompatibility phenotype ."
],
"offsets": [
[
0,
145
]
]
}
]
| [
{
"id": "split_0_train_1760_entity",
"type": "progene_text",
"text": [
"SLG"
],
"offsets": [
[
46,
49
]
],
"normalized": []
},
{
"id": "split_0_train_1761_entity",
"type": "progene_text",
"text": [
"SRK"
],
"offsets": [
[
52,
55
]
],
"normalized": []
},
{
"id": "split_0_train_1762_entity",
"type": "progene_text",
"text": [
"ARC1"
],
"offsets": [
[
67,
71
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1214 | split_0_train_1214 | [
{
"id": "split_0_train_1214_passage",
"type": "progene_text",
"text": [
"Self - incompatibility ( SI ) promotes outbreeding in flowering plants , and in Brassica SI is genetically controlled by the S locus ."
],
"offsets": [
[
0,
134
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1215 | split_0_train_1215 | [
{
"id": "split_0_train_1215_passage",
"type": "progene_text",
"text": [
"Self - incompatible Brassica and self - fertile Arabidopsis belong to the same crucifer family ."
],
"offsets": [
[
0,
96
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1216 | split_0_train_1216 | [
{
"id": "split_0_train_1216_passage",
"type": "progene_text",
"text": [
"In addition , a comparative analysis reveals a high degree of microsynteny between the B. campestris S locus and its homologous region in Arabidopsis - - with the notable exception that the Brassica SI genes , SLG and SRK , are missing ."
],
"offsets": [
[
0,
237
]
]
}
]
| [
{
"id": "split_0_train_1763_entity",
"type": "progene_text",
"text": [
"SLG"
],
"offsets": [
[
210,
213
]
],
"normalized": []
},
{
"id": "split_0_train_1764_entity",
"type": "progene_text",
"text": [
"SRK"
],
"offsets": [
[
218,
221
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1217 | split_0_train_1217 | [
{
"id": "split_0_train_1217_passage",
"type": "progene_text",
"text": [
"Brassica ARC1 encodes a component of the SRK signal transduction pathway leading to self - pollen rejection , and no closely related ARC1 homolog has been identified in Arabidopsis ."
],
"offsets": [
[
0,
182
]
]
}
]
| [
{
"id": "split_0_train_1765_entity",
"type": "progene_text",
"text": [
"ARC1"
],
"offsets": [
[
9,
13
]
],
"normalized": []
},
{
"id": "split_0_train_1766_entity",
"type": "progene_text",
"text": [
"SRK"
],
"offsets": [
[
41,
44
]
],
"normalized": []
},
{
"id": "split_0_train_1767_entity",
"type": "progene_text",
"text": [
"ARC1"
],
"offsets": [
[
133,
137
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1218 | split_0_train_1218 | [
{
"id": "split_0_train_1218_passage",
"type": "progene_text",
"text": [
"The purpose of the research reported here was to introduce Brassica SI components into Arabidopsis in an attempt to compensate for the missing genes and to investigate whether the SI phenotype can be transferred ."
],
"offsets": [
[
0,
213
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1219 | split_0_train_1219 | [
{
"id": "split_0_train_1219_passage",
"type": "progene_text",
"text": [
"Inserts of approximately 40 kb from the fosmid clones F20 and F22 , which span the B. napus W1 SLG - SRK region , were cloned into the plant transformation vector pBIBAC2 ."
],
"offsets": [
[
0,
172
]
]
}
]
| [
{
"id": "split_0_train_1768_entity",
"type": "progene_text",
"text": [
"SLG"
],
"offsets": [
[
95,
98
]
],
"normalized": []
},
{
"id": "split_0_train_1769_entity",
"type": "progene_text",
"text": [
"SRK"
],
"offsets": [
[
101,
104
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1220 | split_0_train_1220 | [
{
"id": "split_0_train_1220_passage",
"type": "progene_text",
"text": [
"Transgenic plants were generated that expressed the Brassica SI genes in the flower buds ."
],
"offsets": [
[
0,
90
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1221 | split_0_train_1221 | [
{
"id": "split_0_train_1221_passage",
"type": "progene_text",
"text": [
"In addition , the endogenous , SLG - like , gene AtS1 was not co - suppressed by the Brassica SLG transgene ."
],
"offsets": [
[
0,
109
]
]
}
]
| [
{
"id": "split_0_train_1770_entity",
"type": "progene_text",
"text": [
"SLG"
],
"offsets": [
[
31,
34
]
],
"normalized": []
},
{
"id": "split_0_train_1771_entity",
"type": "progene_text",
"text": [
"AtS1"
],
"offsets": [
[
49,
53
]
],
"normalized": []
},
{
"id": "split_0_train_1772_entity",
"type": "progene_text",
"text": [
"SLG"
],
"offsets": [
[
94,
97
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1222 | split_0_train_1222 | [
{
"id": "split_0_train_1222_passage",
"type": "progene_text",
"text": [
"No SI phenotype was observed among the T1 BIBAC2 - F20 and BIBAC2 - F22 transgenic plants ."
],
"offsets": [
[
0,
91
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1223 | split_0_train_1223 | [
{
"id": "split_0_train_1223_passage",
"type": "progene_text",
"text": [
"When the ARC1 gene was transformed into BIBAC2 - F20 or BIBAC2 - F22 plants , the resulting BIBAC2 - F20 - ARC1 and BIBAC2 - F22 - ARC1 plants still set seeds normally , and no rejection response was observed when self - incompatible B. napus W1 pollen was placed on BIBAC2 - F20 - ARC1 or BIBAC2 - F22 - ARC1 Arabidopsis stigmas ."
],
"offsets": [
[
0,
331
]
]
}
]
| [
{
"id": "split_0_train_1773_entity",
"type": "progene_text",
"text": [
"ARC1"
],
"offsets": [
[
9,
13
]
],
"normalized": []
},
{
"id": "split_0_train_1774_entity",
"type": "progene_text",
"text": [
"ARC1"
],
"offsets": [
[
107,
111
]
],
"normalized": []
},
{
"id": "split_0_train_1775_entity",
"type": "progene_text",
"text": [
"ARC1"
],
"offsets": [
[
131,
135
]
],
"normalized": []
},
{
"id": "split_0_train_1776_entity",
"type": "progene_text",
"text": [
"ARC1"
],
"offsets": [
[
282,
286
]
],
"normalized": []
},
{
"id": "split_0_train_1777_entity",
"type": "progene_text",
"text": [
"ARC1"
],
"offsets": [
[
305,
309
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1224 | split_0_train_1224 | [
{
"id": "split_0_train_1224_passage",
"type": "progene_text",
"text": [
"Taken together , our results suggest that complementing Arabidopsis genome with Brassica SLG , SRK and ARC1 genes is unlikely to be sufficient to transfer the SI phenotype ."
],
"offsets": [
[
0,
173
]
]
}
]
| [
{
"id": "split_0_train_1778_entity",
"type": "progene_text",
"text": [
"SLG"
],
"offsets": [
[
89,
92
]
],
"normalized": []
},
{
"id": "split_0_train_1779_entity",
"type": "progene_text",
"text": [
"SRK"
],
"offsets": [
[
95,
98
]
],
"normalized": []
},
{
"id": "split_0_train_1780_entity",
"type": "progene_text",
"text": [
"ARC1"
],
"offsets": [
[
103,
107
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1225 | split_0_train_1225 | [
{
"id": "split_0_train_1225_passage",
"type": "progene_text",
"text": [
"Norwalk virus open reading frame 3 encodes a minor structural protein ."
],
"offsets": [
[
0,
71
]
]
}
]
| [
{
"id": "split_0_train_1781_entity",
"type": "progene_text",
"text": [
"structural protein"
],
"offsets": [
[
51,
69
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1226 | split_0_train_1226 | [
{
"id": "split_0_train_1226_passage",
"type": "progene_text",
"text": [
"Norwalk virus ( NV ) is a causative agent of acute epidemic nonbacterial gastroenteritis in humans ."
],
"offsets": [
[
0,
100
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1227 | split_0_train_1227 | [
{
"id": "split_0_train_1227_passage",
"type": "progene_text",
"text": [
"The inability to cultivate NV has required the use of molecular techniques to examine the genome organization and functions of the viral proteins ."
],
"offsets": [
[
0,
147
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1228 | split_0_train_1228 | [
{
"id": "split_0_train_1228_passage",
"type": "progene_text",
"text": [
"The function of the NV protein encoded by open reading frame 3 ( ORF 3 ) has been unknown ."
],
"offsets": [
[
0,
91
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1229 | split_0_train_1229 | [
{
"id": "split_0_train_1229_passage",
"type": "progene_text",
"text": [
"In this paper , we report the characterization of the NV ORF 3 protein expressed in a cell - free translation system and in insect cells and show its association with recombinant virus - like particles ( VLPs ) and NV virions ."
],
"offsets": [
[
0,
227
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1230 | split_0_train_1230 | [
{
"id": "split_0_train_1230_passage",
"type": "progene_text",
"text": [
"Expression of the ORF 3 coding region in rabbit reticulocyte lysates resulted in the production of a single protein with an apparent molecular weight of 23,000 ( 23K protein ) , which is not modified by N - linked glycosylation ."
],
"offsets": [
[
0,
229
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1231 | split_0_train_1231 | [
{
"id": "split_0_train_1231_passage",
"type": "progene_text",
"text": [
"The ORF 3 protein was expressed in insect cells by using two different baculovirus recombinants ; one recombinant contained the entire 3' end of the genome beginning with the ORF 2 coding sequences ( ORFs 2+3) , and the second recombinant contained ORF 3 alone ."
],
"offsets": [
[
0,
262
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1232 | split_0_train_1232 | [
{
"id": "split_0_train_1232_passage",
"type": "progene_text",
"text": [
"Expression from the construct containing both ORF 2 and ORF 3 resulted in the expression of a single protein ( 23K protein ) detected by Western blot analysis with ORF 3 - specific peptide antisera ."
],
"offsets": [
[
0,
199
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1233 | split_0_train_1233 | [
{
"id": "split_0_train_1233_passage",
"type": "progene_text",
"text": [
"However , expression from a construct containing only the ORF 3 coding sequences resulted in the production of multiple forms of the ORF 3 protein ranging in size from 23,000 to 35,000 ."
],
"offsets": [
[
0,
186
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1234 | split_0_train_1234 | [
{
"id": "split_0_train_1234_passage",
"type": "progene_text",
"text": [
"Indirect - immunofluorescence studies using an ORF 3 peptide antiserum showed that the ORF 3 protein is localized to the cytoplasm of infected insect cells ."
],
"offsets": [
[
0,
157
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1235 | split_0_train_1235 | [
{
"id": "split_0_train_1235_passage",
"type": "progene_text",
"text": [
"The 23K ORF 3 protein was consistently associated with recombinant VLPs purified from the media of insect cells infected with a baculovirus recombinant containing the entire 3' end of the NV genome ."
],
"offsets": [
[
0,
199
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1236 | split_0_train_1236 | [
{
"id": "split_0_train_1236_passage",
"type": "progene_text",
"text": [
"Western blot analysis of NV purified from the stools of NV - infected volunteers revealed the presence of a 35K protein as well as multiple higher - molecular - weight bands specifically recognized by an ORF 3 peptide antiserum ."
],
"offsets": [
[
0,
229
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1237 | split_0_train_1237 | [
{
"id": "split_0_train_1237_passage",
"type": "progene_text",
"text": [
"These results indicate that the ORF 3 protein is a minor structural protein of the virion ."
],
"offsets": [
[
0,
91
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1238 | split_0_train_1238 | [
{
"id": "split_0_train_1238_passage",
"type": "progene_text",
"text": [
"Transcription of the insecticidal crystal protein genes of Bacillus thuringiensis ."
],
"offsets": [
[
0,
83
]
]
}
]
| [
{
"id": "split_0_train_1782_entity",
"type": "progene_text",
"text": [
"crystal protein"
],
"offsets": [
[
34,
49
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1239 | split_0_train_1239 | [
{
"id": "split_0_train_1239_passage",
"type": "progene_text",
"text": [
"Production of a large amount of insecticidal crystal proteins encoded on large plasmids is largely dependent upon the mother cell , Bacillus thuringiensis ( B. thuringiensis , also Bt ) , specific transcription systems attributable to sporulation ."
],
"offsets": [
[
0,
248
]
]
}
]
| [
{
"id": "split_0_train_1783_entity",
"type": "progene_text",
"text": [
"crystal proteins"
],
"offsets": [
[
45,
61
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1240 | split_0_train_1240 | [
{
"id": "split_0_train_1240_passage",
"type": "progene_text",
"text": [
"In the middle stages of sporulation , cry4A is most actively transcribed from the promoter cry4A - P1 ."
],
"offsets": [
[
0,
103
]
]
}
]
| [
{
"id": "split_0_train_1784_entity",
"type": "progene_text",
"text": [
"cry4A"
],
"offsets": [
[
38,
43
]
],
"normalized": []
},
{
"id": "split_0_train_1785_entity",
"type": "progene_text",
"text": [
"cry4A"
],
"offsets": [
[
91,
96
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1241 | split_0_train_1241 | [
{
"id": "split_0_train_1241_passage",
"type": "progene_text",
"text": [
"The proximal transcriptional start point of cry4A , which is under the control of the promoter P1 , is used in Bacillus subtilis ( B. subtilis ) in the middle stage of sporulation ."
],
"offsets": [
[
0,
181
]
]
}
]
| [
{
"id": "split_0_train_1786_entity",
"type": "progene_text",
"text": [
"cry4A"
],
"offsets": [
[
44,
49
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1242 | split_0_train_1242 | [
{
"id": "split_0_train_1242_passage",
"type": "progene_text",
"text": [
"The nucleotide sequence that determines the cry4A - P1 promoter is homologous to the consensus sequence for the promoter of sigma E - specific genes in B. subtilis , and to those promoters of the insecticidal protein genes that are efficiently transcribed in vitro with the RNA polymerase E sigma 35 isolated from B. thuringiensis ."
],
"offsets": [
[
0,
332
]
]
}
]
| [
{
"id": "split_0_train_1787_entity",
"type": "progene_text",
"text": [
"cry4A"
],
"offsets": [
[
44,
49
]
],
"normalized": []
},
{
"id": "split_0_train_1788_entity",
"type": "progene_text",
"text": [
"sigma E"
],
"offsets": [
[
124,
131
]
],
"normalized": []
},
{
"id": "split_0_train_1789_entity",
"type": "progene_text",
"text": [
"RNA polymerase E sigma 35"
],
"offsets": [
[
274,
299
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1243 | split_0_train_1243 | [
{
"id": "split_0_train_1243_passage",
"type": "progene_text",
"text": [
"The sigma factor sigma 35 of B. thuringiensis is highly homologous and functionally equivalent to sigma E of B. subtilis ."
],
"offsets": [
[
0,
122
]
]
}
]
| [
{
"id": "split_0_train_1790_entity",
"type": "progene_text",
"text": [
"sigma factor"
],
"offsets": [
[
4,
16
]
],
"normalized": []
},
{
"id": "split_0_train_1791_entity",
"type": "progene_text",
"text": [
"sigma 35"
],
"offsets": [
[
17,
25
]
],
"normalized": []
},
{
"id": "split_0_train_1792_entity",
"type": "progene_text",
"text": [
"sigma E"
],
"offsets": [
[
98,
105
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1244 | split_0_train_1244 | [
{
"id": "split_0_train_1244_passage",
"type": "progene_text",
"text": [
"These results suggest that the cry4A transcription from P1 is under the control of sigma E in B. subtilis , and under the control of sigma 35 in B. thuringiensis ."
],
"offsets": [
[
0,
163
]
]
}
]
| [
{
"id": "split_0_train_1793_entity",
"type": "progene_text",
"text": [
"cry4A"
],
"offsets": [
[
31,
36
]
],
"normalized": []
},
{
"id": "split_0_train_1794_entity",
"type": "progene_text",
"text": [
"sigma E"
],
"offsets": [
[
83,
90
]
],
"normalized": []
},
{
"id": "split_0_train_1795_entity",
"type": "progene_text",
"text": [
"sigma 35"
],
"offsets": [
[
133,
141
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1245 | split_0_train_1245 | [
{
"id": "split_0_train_1245_passage",
"type": "progene_text",
"text": [
"Cloning , genomic organization , and characterization of a human cholinephosphotransferase ."
],
"offsets": [
[
0,
92
]
]
}
]
| [
{
"id": "split_0_train_1796_entity",
"type": "progene_text",
"text": [
"cholinephosphotransferase"
],
"offsets": [
[
65,
90
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1246 | split_0_train_1246 | [
{
"id": "split_0_train_1246_passage",
"type": "progene_text",
"text": [
"A cholinephosphotransferase activity catalyzes the final step in the de novo synthesis of phosphatidylcholine via the transfer of a phosphocholine moiety from CDP choline to diacylglycerol ."
],
"offsets": [
[
0,
190
]
]
}
]
| [
{
"id": "split_0_train_1797_entity",
"type": "progene_text",
"text": [
"cholinephosphotransferase"
],
"offsets": [
[
2,
27
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1247 | split_0_train_1247 | [
{
"id": "split_0_train_1247_passage",
"type": "progene_text",
"text": [
"Ethanolaminephosphotransferase activity catalyzes a similar reaction substituting CDP ethanolamine as the phosphobase donor ."
],
"offsets": [
[
0,
125
]
]
}
]
| [
{
"id": "split_0_train_1798_entity",
"type": "progene_text",
"text": [
"Ethanolaminephosphotransferase"
],
"offsets": [
[
0,
30
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1248 | split_0_train_1248 | [
{
"id": "split_0_train_1248_passage",
"type": "progene_text",
"text": [
"We report the identification and cloning of a human cDNA ( human cholinephosphotransferase ( hCPT1 ) ) that codes for a cholinephosphotransferase - specific enzyme ."
],
"offsets": [
[
0,
165
]
]
}
]
| [
{
"id": "split_0_train_1799_entity",
"type": "progene_text",
"text": [
"cholinephosphotransferase"
],
"offsets": [
[
65,
90
]
],
"normalized": []
},
{
"id": "split_0_train_1800_entity",
"type": "progene_text",
"text": [
"hCPT1"
],
"offsets": [
[
93,
98
]
],
"normalized": []
},
{
"id": "split_0_train_1801_entity",
"type": "progene_text",
"text": [
"cholinephosphotransferase"
],
"offsets": [
[
120,
145
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1249 | split_0_train_1249 | [
{
"id": "split_0_train_1249_passage",
"type": "progene_text",
"text": [
"This was demonstrated using in vitro enzyme assays and in vivo measurement of the reconstitution of the phosphatidylcholine and phosphatidylethanolamine biosynthetic pathways in yeast cells devoid of their own endogenous cholinephosphotransferase and ethanolaminephosphotransferase activities ."
],
"offsets": [
[
0,
294
]
]
}
]
| [
{
"id": "split_0_train_1802_entity",
"type": "progene_text",
"text": [
"cholinephosphotransferase"
],
"offsets": [
[
221,
246
]
],
"normalized": []
},
{
"id": "split_0_train_1803_entity",
"type": "progene_text",
"text": [
"ethanolaminephosphotransferase"
],
"offsets": [
[
251,
281
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1250 | split_0_train_1250 | [
{
"id": "split_0_train_1250_passage",
"type": "progene_text",
"text": [
"This contrasted with our previously cloned human choline / ethanolaminephosphotransferase cDNA that was demonstrated to code for a dual specificity choline / ethanolaminephosphotransferase ."
],
"offsets": [
[
0,
190
]
]
}
]
| [
{
"id": "split_0_train_1804_entity",
"type": "progene_text",
"text": [
"choline / ethanolaminephosphotransferase"
],
"offsets": [
[
49,
89
]
],
"normalized": []
},
{
"id": "split_0_train_1805_entity",
"type": "progene_text",
"text": [
"choline / ethanolaminephosphotransferase"
],
"offsets": [
[
148,
188
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1251 | split_0_train_1251 | [
{
"id": "split_0_train_1251_passage",
"type": "progene_text",
"text": [
"The hCPT1 and human choline / ethanolaminephosphotransferase ( hCEPT1 ) predicted amino acid sequences possessed 60 % overall identity and had only one variation in the amino acid residues within the CDP - alcohol phosphotransferase catalytic motif ."
],
"offsets": [
[
0,
250
]
]
}
]
| [
{
"id": "split_0_train_1806_entity",
"type": "progene_text",
"text": [
"hCPT1"
],
"offsets": [
[
4,
9
]
],
"normalized": []
},
{
"id": "split_0_train_1807_entity",
"type": "progene_text",
"text": [
"choline / ethanolaminephosphotransferase"
],
"offsets": [
[
20,
60
]
],
"normalized": []
},
{
"id": "split_0_train_1808_entity",
"type": "progene_text",
"text": [
"hCEPT1"
],
"offsets": [
[
63,
69
]
],
"normalized": []
},
{
"id": "split_0_train_1809_entity",
"type": "progene_text",
"text": [
"CDP - alcohol phosphotransferase"
],
"offsets": [
[
200,
232
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1252 | split_0_train_1252 | [
{
"id": "split_0_train_1252_passage",
"type": "progene_text",
"text": [
"In vitro assessment of hCPT1 and hCEPT1 derived cholinephosphotransferase activities also revealed differences in diradylglycerol specificities including their capacity to synthesize platelet - activating factor and platelet - activating factor precursor ."
],
"offsets": [
[
0,
256
]
]
}
]
| [
{
"id": "split_0_train_1810_entity",
"type": "progene_text",
"text": [
"hCPT1"
],
"offsets": [
[
23,
28
]
],
"normalized": []
},
{
"id": "split_0_train_1811_entity",
"type": "progene_text",
"text": [
"hCEPT1"
],
"offsets": [
[
33,
39
]
],
"normalized": []
},
{
"id": "split_0_train_1812_entity",
"type": "progene_text",
"text": [
"cholinephosphotransferase"
],
"offsets": [
[
48,
73
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1253 | split_0_train_1253 | [
{
"id": "split_0_train_1253_passage",
"type": "progene_text",
"text": [
"Expression of the hCPT1 mRNA varied greater than 100 - fold between tissues and was most abundant in testis followed by colon , small intestine , heart , prostate , and spleen ."
],
"offsets": [
[
0,
177
]
]
}
]
| [
{
"id": "split_0_train_1813_entity",
"type": "progene_text",
"text": [
"hCPT1"
],
"offsets": [
[
18,
23
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1254 | split_0_train_1254 | [
{
"id": "split_0_train_1254_passage",
"type": "progene_text",
"text": [
"This was in marked contrast to the hCEPT1 mRNA , which has been found in similar abundance in all tissues tested to date ."
],
"offsets": [
[
0,
122
]
]
}
]
| [
{
"id": "split_0_train_1814_entity",
"type": "progene_text",
"text": [
"hCEPT1"
],
"offsets": [
[
35,
41
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1255 | split_0_train_1255 | [
{
"id": "split_0_train_1255_passage",
"type": "progene_text",
"text": [
"Both the hCPT1 and hCEPT1 enzymes were able to reconstitute the synthesis of PC in yeast to levels provided by the endogenous yeast cholinephosphotransferase ; however , only hCEPT1 - derived activity was able to complement the yeast CPT1 gene in its interaction with SEC14 and affect cell growth ."
],
"offsets": [
[
0,
298
]
]
}
]
| [
{
"id": "split_0_train_1815_entity",
"type": "progene_text",
"text": [
"hCPT1"
],
"offsets": [
[
9,
14
]
],
"normalized": []
},
{
"id": "split_0_train_1816_entity",
"type": "progene_text",
"text": [
"hCEPT1"
],
"offsets": [
[
19,
25
]
],
"normalized": []
},
{
"id": "split_0_train_1817_entity",
"type": "progene_text",
"text": [
"cholinephosphotransferase"
],
"offsets": [
[
132,
157
]
],
"normalized": []
},
{
"id": "split_0_train_1818_entity",
"type": "progene_text",
"text": [
"hCEPT1"
],
"offsets": [
[
175,
181
]
],
"normalized": []
},
{
"id": "split_0_train_1819_entity",
"type": "progene_text",
"text": [
"CPT1"
],
"offsets": [
[
234,
238
]
],
"normalized": []
},
{
"id": "split_0_train_1820_entity",
"type": "progene_text",
"text": [
"SEC14"
],
"offsets": [
[
268,
273
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1256 | split_0_train_1256 | [
{
"id": "split_0_train_1256_passage",
"type": "progene_text",
"text": [
"Phosphate starvation - inducible proteins of Bacillus subtilis : proteomics and transcriptional analysis ."
],
"offsets": [
[
0,
106
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1257 | split_0_train_1257 | [
{
"id": "split_0_train_1257_passage",
"type": "progene_text",
"text": [
"The phosphate starvation response in Bacillus subtilis was analyzed using two - dimensional ( 2D ) polyacrylamide gel electrophoresis of cell extracts and supernatants from phosphate - starved cells ."
],
"offsets": [
[
0,
200
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1258 | split_0_train_1258 | [
{
"id": "split_0_train_1258_passage",
"type": "progene_text",
"text": [
"Most of the phosphate starvation - induced proteins are under the control of sigma(B) , the activity of which is increased by energy depletion ."
],
"offsets": [
[
0,
144
]
]
}
]
| [
{
"id": "split_0_train_1821_entity",
"type": "progene_text",
"text": [
"sigma(B)"
],
"offsets": [
[
77,
85
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1259 | split_0_train_1259 | [
{
"id": "split_0_train_1259_passage",
"type": "progene_text",
"text": [
"In order to define the proteins belonging to the Pho regulon , which is regulated by the two - component regulatory proteins PhoP and PhoR , the 2D protein pattern of the wild type was compared with those of a sigB mutant and a phoR mutant ."
],
"offsets": [
[
0,
241
]
]
}
]
| [
{
"id": "split_0_train_1822_entity",
"type": "progene_text",
"text": [
"Pho"
],
"offsets": [
[
49,
52
]
],
"normalized": []
},
{
"id": "split_0_train_1823_entity",
"type": "progene_text",
"text": [
"PhoP"
],
"offsets": [
[
125,
129
]
],
"normalized": []
},
{
"id": "split_0_train_1824_entity",
"type": "progene_text",
"text": [
"PhoR"
],
"offsets": [
[
134,
138
]
],
"normalized": []
},
{
"id": "split_0_train_1825_entity",
"type": "progene_text",
"text": [
"sigB"
],
"offsets": [
[
210,
214
]
],
"normalized": []
},
{
"id": "split_0_train_1826_entity",
"type": "progene_text",
"text": [
"phoR"
],
"offsets": [
[
228,
232
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1260 | split_0_train_1260 | [
{
"id": "split_0_train_1260_passage",
"type": "progene_text",
"text": [
"By matrix - assisted laser desorption ionization - time of flight mass spectrometry , two alkaline phosphatases ( APases ) ( PhoA and PhoB ) , an APase - alkaline phosphodiesterase ( PhoD ) , a glycerophosphoryl diester phosphodiesterase ( GlpQ ) , and the lipoprotein YdhF were identified as very strongly induced PhoPR - dependent proteins secreted into the extracellular medium ."
],
"offsets": [
[
0,
382
]
]
}
]
| [
{
"id": "split_0_train_1827_entity",
"type": "progene_text",
"text": [
"alkaline phosphatases"
],
"offsets": [
[
90,
111
]
],
"normalized": []
},
{
"id": "split_0_train_1828_entity",
"type": "progene_text",
"text": [
"APases"
],
"offsets": [
[
114,
120
]
],
"normalized": []
},
{
"id": "split_0_train_1829_entity",
"type": "progene_text",
"text": [
"PhoA"
],
"offsets": [
[
125,
129
]
],
"normalized": []
},
{
"id": "split_0_train_1830_entity",
"type": "progene_text",
"text": [
"PhoB"
],
"offsets": [
[
134,
138
]
],
"normalized": []
},
{
"id": "split_0_train_1831_entity",
"type": "progene_text",
"text": [
"APase"
],
"offsets": [
[
146,
151
]
],
"normalized": []
},
{
"id": "split_0_train_1832_entity",
"type": "progene_text",
"text": [
"alkaline phosphodiesterase"
],
"offsets": [
[
154,
180
]
],
"normalized": []
},
{
"id": "split_0_train_1833_entity",
"type": "progene_text",
"text": [
"PhoD"
],
"offsets": [
[
183,
187
]
],
"normalized": []
},
{
"id": "split_0_train_1834_entity",
"type": "progene_text",
"text": [
"glycerophosphoryl diester phosphodiesterase"
],
"offsets": [
[
194,
237
]
],
"normalized": []
},
{
"id": "split_0_train_1835_entity",
"type": "progene_text",
"text": [
"GlpQ"
],
"offsets": [
[
240,
244
]
],
"normalized": []
},
{
"id": "split_0_train_1836_entity",
"type": "progene_text",
"text": [
"YdhF"
],
"offsets": [
[
269,
273
]
],
"normalized": []
},
{
"id": "split_0_train_1837_entity",
"type": "progene_text",
"text": [
"PhoPR"
],
"offsets": [
[
315,
320
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1261 | split_0_train_1261 | [
{
"id": "split_0_train_1261_passage",
"type": "progene_text",
"text": [
"In the cytoplasmic fraction , PstB1 , PstB2 , and TuaD were identified as already known PhoPR - dependent proteins , in addition to PhoB , PhoD , and the previously described PstS ."
],
"offsets": [
[
0,
181
]
]
}
]
| [
{
"id": "split_0_train_1838_entity",
"type": "progene_text",
"text": [
"PstB1"
],
"offsets": [
[
30,
35
]
],
"normalized": []
},
{
"id": "split_0_train_1839_entity",
"type": "progene_text",
"text": [
"PstB2"
],
"offsets": [
[
38,
43
]
],
"normalized": []
},
{
"id": "split_0_train_1840_entity",
"type": "progene_text",
"text": [
"TuaD"
],
"offsets": [
[
50,
54
]
],
"normalized": []
},
{
"id": "split_0_train_1841_entity",
"type": "progene_text",
"text": [
"PhoPR"
],
"offsets": [
[
88,
93
]
],
"normalized": []
},
{
"id": "split_0_train_1842_entity",
"type": "progene_text",
"text": [
"PhoB"
],
"offsets": [
[
132,
136
]
],
"normalized": []
},
{
"id": "split_0_train_1843_entity",
"type": "progene_text",
"text": [
"PhoD"
],
"offsets": [
[
139,
143
]
],
"normalized": []
},
{
"id": "split_0_train_1844_entity",
"type": "progene_text",
"text": [
"PstS"
],
"offsets": [
[
175,
179
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1262 | split_0_train_1262 | [
{
"id": "split_0_train_1262_passage",
"type": "progene_text",
"text": [
"Transcriptional studies of glpQ and ydhF confirmed the strong PhoPR dependence ."
],
"offsets": [
[
0,
80
]
]
}
]
| [
{
"id": "split_0_train_1845_entity",
"type": "progene_text",
"text": [
"glpQ"
],
"offsets": [
[
27,
31
]
],
"normalized": []
},
{
"id": "split_0_train_1846_entity",
"type": "progene_text",
"text": [
"ydhF"
],
"offsets": [
[
36,
40
]
],
"normalized": []
},
{
"id": "split_0_train_1847_entity",
"type": "progene_text",
"text": [
"PhoPR"
],
"offsets": [
[
62,
67
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1263 | split_0_train_1263 | [
{
"id": "split_0_train_1263_passage",
"type": "progene_text",
"text": [
"Northern hybridization and primer extension experiments showed that glpQ is transcribed monocistronically from a sigma ( A ) promoter which is overlapped by four putative TT ( A / T ) ACA - like PhoP binding sites ."
],
"offsets": [
[
0,
215
]
]
}
]
| [
{
"id": "split_0_train_1848_entity",
"type": "progene_text",
"text": [
"glpQ"
],
"offsets": [
[
68,
72
]
],
"normalized": []
},
{
"id": "split_0_train_1849_entity",
"type": "progene_text",
"text": [
"sigma ( A )"
],
"offsets": [
[
113,
124
]
],
"normalized": []
},
{
"id": "split_0_train_1850_entity",
"type": "progene_text",
"text": [
"PhoP"
],
"offsets": [
[
195,
199
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1264 | split_0_train_1264 | [
{
"id": "split_0_train_1264_passage",
"type": "progene_text",
"text": [
"Furthermore , ydhF might be cotranscribed with phoB initiating from the phoB promoter ."
],
"offsets": [
[
0,
87
]
]
}
]
| [
{
"id": "split_0_train_1851_entity",
"type": "progene_text",
"text": [
"ydhF"
],
"offsets": [
[
14,
18
]
],
"normalized": []
},
{
"id": "split_0_train_1852_entity",
"type": "progene_text",
"text": [
"phoB"
],
"offsets": [
[
47,
51
]
],
"normalized": []
},
{
"id": "split_0_train_1853_entity",
"type": "progene_text",
"text": [
"phoB"
],
"offsets": [
[
72,
76
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1265 | split_0_train_1265 | [
{
"id": "split_0_train_1265_passage",
"type": "progene_text",
"text": [
"Only a small group of proteins remained phosphate starvation inducible in both phoR and sigB mutant and did not form a unique regulation group ."
],
"offsets": [
[
0,
144
]
]
}
]
| [
{
"id": "split_0_train_1854_entity",
"type": "progene_text",
"text": [
"phoR"
],
"offsets": [
[
79,
83
]
],
"normalized": []
},
{
"id": "split_0_train_1855_entity",
"type": "progene_text",
"text": [
"sigB"
],
"offsets": [
[
88,
92
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1266 | split_0_train_1266 | [
{
"id": "split_0_train_1266_passage",
"type": "progene_text",
"text": [
"Among these , YfhM and YjbC were controlled by sigma ( B ) - dependent and unknown PhoPR - independent mechanisms ."
],
"offsets": [
[
0,
115
]
]
}
]
| [
{
"id": "split_0_train_1856_entity",
"type": "progene_text",
"text": [
"YfhM"
],
"offsets": [
[
14,
18
]
],
"normalized": []
},
{
"id": "split_0_train_1857_entity",
"type": "progene_text",
"text": [
"YjbC"
],
"offsets": [
[
23,
27
]
],
"normalized": []
},
{
"id": "split_0_train_1858_entity",
"type": "progene_text",
"text": [
"sigma ( B )"
],
"offsets": [
[
47,
58
]
],
"normalized": []
},
{
"id": "split_0_train_1859_entity",
"type": "progene_text",
"text": [
"PhoPR"
],
"offsets": [
[
83,
88
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1267 | split_0_train_1267 | [
{
"id": "split_0_train_1267_passage",
"type": "progene_text",
"text": [
"Furthermore , YtxH and YvyD seemed to be induced after phosphate starvation in the wild type in a sigma ( B ) - dependent manner and in the sigB mutant probably via sigma(H) ."
],
"offsets": [
[
0,
175
]
]
}
]
| [
{
"id": "split_0_train_1860_entity",
"type": "progene_text",
"text": [
"YtxH"
],
"offsets": [
[
14,
18
]
],
"normalized": []
},
{
"id": "split_0_train_1861_entity",
"type": "progene_text",
"text": [
"YvyD"
],
"offsets": [
[
23,
27
]
],
"normalized": []
},
{
"id": "split_0_train_1862_entity",
"type": "progene_text",
"text": [
"sigma ( B )"
],
"offsets": [
[
98,
109
]
],
"normalized": []
},
{
"id": "split_0_train_1863_entity",
"type": "progene_text",
"text": [
"sigB"
],
"offsets": [
[
140,
144
]
],
"normalized": []
},
{
"id": "split_0_train_1864_entity",
"type": "progene_text",
"text": [
"sigma(H)"
],
"offsets": [
[
165,
173
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1268 | split_0_train_1268 | [
{
"id": "split_0_train_1268_passage",
"type": "progene_text",
"text": [
"YxiE was induced by phosphate starvation independently of sigma(B) and PhoPR ."
],
"offsets": [
[
0,
78
]
]
}
]
| [
{
"id": "split_0_train_1865_entity",
"type": "progene_text",
"text": [
"YxiE"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_1866_entity",
"type": "progene_text",
"text": [
"sigma(B)"
],
"offsets": [
[
58,
66
]
],
"normalized": []
},
{
"id": "split_0_train_1867_entity",
"type": "progene_text",
"text": [
"PhoPR"
],
"offsets": [
[
71,
76
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1269 | split_0_train_1269 | [
{
"id": "split_0_train_1269_passage",
"type": "progene_text",
"text": [
"Oxygen and haem regulate the synthesis of peroxisomal proteins : catalase A , acyl-CoA oxidase and Pex1p in the yeast Saccharomyces cerevisiae ; the regulation of these proteins by oxygen is not mediated by haem ."
],
"offsets": [
[
0,
213
]
]
}
]
| [
{
"id": "split_0_train_1868_entity",
"type": "progene_text",
"text": [
"catalase A"
],
"offsets": [
[
65,
75
]
],
"normalized": []
},
{
"id": "split_0_train_1869_entity",
"type": "progene_text",
"text": [
"acyl-CoA oxidase"
],
"offsets": [
[
78,
94
]
],
"normalized": []
},
{
"id": "split_0_train_1870_entity",
"type": "progene_text",
"text": [
"Pex1p"
],
"offsets": [
[
99,
104
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1270 | split_0_train_1270 | [
{
"id": "split_0_train_1270_passage",
"type": "progene_text",
"text": [
"Saccharomyces cerevisiae genes related to respiration are typically controlled by oxygen and haem ."
],
"offsets": [
[
0,
99
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1271 | split_0_train_1271 | [
{
"id": "split_0_train_1271_passage",
"type": "progene_text",
"text": [
"Usually the regulation by these factors is co - ordinated ; haem is indicated as the oxygen sensor ."
],
"offsets": [
[
0,
100
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1272 | split_0_train_1272 | [
{
"id": "split_0_train_1272_passage",
"type": "progene_text",
"text": [
"However , the responsiveness of peroxisome functions to these regulatory factors is poorly understood ."
],
"offsets": [
[
0,
103
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1273 | split_0_train_1273 | [
{
"id": "split_0_train_1273_passage",
"type": "progene_text",
"text": [
"The expression of CTA1 , POX1 and PEX1 genes encoding the peroxisomal proteins catalase A , acyl-CoA oxidase and Pex1p peroxin respectively was studied under various conditions : in anaerobiosis , in the absence of haem and in respiratory incompetence caused by the lack of a mitochondrial genome ( rho ( 0 ) ) ."
],
"offsets": [
[
0,
312
]
]
}
]
| [
{
"id": "split_0_train_1871_entity",
"type": "progene_text",
"text": [
"CTA1"
],
"offsets": [
[
18,
22
]
],
"normalized": []
},
{
"id": "split_0_train_1872_entity",
"type": "progene_text",
"text": [
"POX1"
],
"offsets": [
[
25,
29
]
],
"normalized": []
},
{
"id": "split_0_train_1873_entity",
"type": "progene_text",
"text": [
"PEX1"
],
"offsets": [
[
34,
38
]
],
"normalized": []
},
{
"id": "split_0_train_1874_entity",
"type": "progene_text",
"text": [
"catalase A"
],
"offsets": [
[
79,
89
]
],
"normalized": []
},
{
"id": "split_0_train_1875_entity",
"type": "progene_text",
"text": [
"acyl-CoA oxidase"
],
"offsets": [
[
92,
108
]
],
"normalized": []
},
{
"id": "split_0_train_1876_entity",
"type": "progene_text",
"text": [
"Pex1p"
],
"offsets": [
[
113,
118
]
],
"normalized": []
},
{
"id": "split_0_train_1877_entity",
"type": "progene_text",
"text": [
"peroxin"
],
"offsets": [
[
119,
126
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1274 | split_0_train_1274 | [
{
"id": "split_0_train_1274_passage",
"type": "progene_text",
"text": [
"The influence of haem deficiency or rho(0) on peroxisomal morphology was also investigated ."
],
"offsets": [
[
0,
92
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1275 | split_0_train_1275 | [
{
"id": "split_0_train_1275_passage",
"type": "progene_text",
"text": [
"Respiratory incompetence has no effect on the expression of CTA1 and POX1 , whereas in the absence of haem their expression is markedly decreased ."
],
"offsets": [
[
0,
147
]
]
}
]
| [
{
"id": "split_0_train_1878_entity",
"type": "progene_text",
"text": [
"CTA1"
],
"offsets": [
[
60,
64
]
],
"normalized": []
},
{
"id": "split_0_train_1879_entity",
"type": "progene_text",
"text": [
"POX1"
],
"offsets": [
[
69,
73
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1276 | split_0_train_1276 | [
{
"id": "split_0_train_1276_passage",
"type": "progene_text",
"text": [
"The synthesis of Pex1p is decreased in rho ( 0 ) cells and is decreased even more in haem - deficient cells ."
],
"offsets": [
[
0,
109
]
]
}
]
| [
{
"id": "split_0_train_1880_entity",
"type": "progene_text",
"text": [
"Pex1p"
],
"offsets": [
[
17,
22
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1277 | split_0_train_1277 | [
{
"id": "split_0_train_1277_passage",
"type": "progene_text",
"text": [
"Nevertheless , peroxisomal morphology in both these types of cell does not differ significantly from the morphology of peroxisomes in wild - type cells ."
],
"offsets": [
[
0,
153
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1278 | split_0_train_1278 | [
{
"id": "split_0_train_1278_passage",
"type": "progene_text",
"text": [
"The down - regulating effect of anoxia on the expression of CTA1 and POX1 is even stronger than the effect of haem deficiency and is not reversed by the addition of exogenous haem or the presence of endogenous haem ."
],
"offsets": [
[
0,
216
]
]
}
]
| [
{
"id": "split_0_train_1881_entity",
"type": "progene_text",
"text": [
"CTA1"
],
"offsets": [
[
60,
64
]
],
"normalized": []
},
{
"id": "split_0_train_1882_entity",
"type": "progene_text",
"text": [
"POX1"
],
"offsets": [
[
69,
73
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1279 | split_0_train_1279 | [
{
"id": "split_0_train_1279_passage",
"type": "progene_text",
"text": [
"Moreover , neither of these genes responds to the known haem - controlled transcriptional factor Hap1p ."
],
"offsets": [
[
0,
104
]
]
}
]
| [
{
"id": "split_0_train_1883_entity",
"type": "progene_text",
"text": [
"transcriptional factor"
],
"offsets": [
[
74,
96
]
],
"normalized": []
},
{
"id": "split_0_train_1884_entity",
"type": "progene_text",
"text": [
"Hap1p"
],
"offsets": [
[
97,
102
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1280 | split_0_train_1280 | [
{
"id": "split_0_train_1280_passage",
"type": "progene_text",
"text": [
"In contrast with the other two genes studied , PEX1 is up - regulated in anaerobiosis ."
],
"offsets": [
[
0,
87
]
]
}
]
| [
{
"id": "split_0_train_1885_entity",
"type": "progene_text",
"text": [
"PEX1"
],
"offsets": [
[
47,
51
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1281 | split_0_train_1281 | [
{
"id": "split_0_train_1281_passage",
"type": "progene_text",
"text": [
"The existence of one or more novel mechanisms of regulation of peroxisomal genes by haem and oxygen , different from those already known in S. cerevisiae , is postulated ."
],
"offsets": [
[
0,
171
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1282 | split_0_train_1282 | [
{
"id": "split_0_train_1282_passage",
"type": "progene_text",
"text": [
"Analysis of bruchid resistance in the wild common bean accession G02771 : no evidence for insecticidal activity of arcelin 5 ."
],
"offsets": [
[
0,
126
]
]
}
]
| [
{
"id": "split_0_train_1886_entity",
"type": "progene_text",
"text": [
"arcelin 5"
],
"offsets": [
[
115,
124
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1283 | split_0_train_1283 | [
{
"id": "split_0_train_1283_passage",
"type": "progene_text",
"text": [
"Arcelins are abundant seed storage proteins thought to be implicated in the resistance of wild Phaseolus vulgaris ( L. ) genotypes against Zabrotes subfasciatus ( Boheman ) , an important storage insect pest of common bean ."
],
"offsets": [
[
0,
224
]
]
}
]
| [
{
"id": "split_0_train_1887_entity",
"type": "progene_text",
"text": [
"Arcelins"
],
"offsets": [
[
0,
8
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1284 | split_0_train_1284 | [
{
"id": "split_0_train_1284_passage",
"type": "progene_text",
"text": [
"Here , the insecticidal activity of the arcelin-5 variant that is present in the highly resistant P. vulgaris accession G02771 was investigated ."
],
"offsets": [
[
0,
145
]
]
}
]
| [
{
"id": "split_0_train_1888_entity",
"type": "progene_text",
"text": [
"arcelin-5"
],
"offsets": [
[
40,
49
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1285 | split_0_train_1285 | [
{
"id": "split_0_train_1285_passage",
"type": "progene_text",
"text": [
"No correlation could be established between the presence of arcelin 5 and the insecticidal effects observed in G02771 seeds ."
],
"offsets": [
[
0,
125
]
]
}
]
| [
{
"id": "split_0_train_1889_entity",
"type": "progene_text",
"text": [
"arcelin 5"
],
"offsets": [
[
60,
69
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1286 | split_0_train_1286 | [
{
"id": "split_0_train_1286_passage",
"type": "progene_text",
"text": [
"Insect feeding assays with artificial seeds into which purified arcelin-5 protein was incorporated and with transgenic P. acutifolius ( A. Gray ) seeds in which the arcelin - 5 genes were expressed , showed that the presence of arcelin - 5 proteins , even at elevated levels , was not sufficient to achieve adequate resistance against Z. subfasciatus ."
],
"offsets": [
[
0,
352
]
]
}
]
| [
{
"id": "split_0_train_1890_entity",
"type": "progene_text",
"text": [
"arcelin-5"
],
"offsets": [
[
64,
73
]
],
"normalized": []
},
{
"id": "split_0_train_1891_entity",
"type": "progene_text",
"text": [
"arcelin - 5"
],
"offsets": [
[
165,
176
]
],
"normalized": []
},
{
"id": "split_0_train_1892_entity",
"type": "progene_text",
"text": [
"arcelin - 5"
],
"offsets": [
[
228,
239
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1287 | split_0_train_1287 | [
{
"id": "split_0_train_1287_passage",
"type": "progene_text",
"text": [
"The same might apply to other arcelin variants ."
],
"offsets": [
[
0,
48
]
]
}
]
| [
{
"id": "split_0_train_1893_entity",
"type": "progene_text",
"text": [
"arcelin"
],
"offsets": [
[
30,
37
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1288 | split_0_train_1288 | [
{
"id": "split_0_train_1288_passage",
"type": "progene_text",
"text": [
"Nevertheless , as resistance is clearly closely linked to the presence of the arcelin-1 or arcelin-5 locus , arcelins remain useful markers in breeding programmes aimed at introgressing high levels of resistance to Z. subfasciatus in P. vulgaris cultivars ."
],
"offsets": [
[
0,
257
]
]
}
]
| [
{
"id": "split_0_train_1894_entity",
"type": "progene_text",
"text": [
"arcelin-1"
],
"offsets": [
[
78,
87
]
],
"normalized": []
},
{
"id": "split_0_train_1895_entity",
"type": "progene_text",
"text": [
"arcelin-5"
],
"offsets": [
[
91,
100
]
],
"normalized": []
},
{
"id": "split_0_train_1896_entity",
"type": "progene_text",
"text": [
"arcelins"
],
"offsets": [
[
109,
117
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1289 | split_0_train_1289 | [
{
"id": "split_0_train_1289_passage",
"type": "progene_text",
"text": [
"Fibroblast growth factor - 10 : a stromal mediator of epithelial function in the ovine uterus ."
],
"offsets": [
[
0,
95
]
]
}
]
| [
{
"id": "split_0_train_1897_entity",
"type": "progene_text",
"text": [
"Fibroblast growth factor - 10"
],
"offsets": [
[
0,
29
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1290 | split_0_train_1290 | [
{
"id": "split_0_train_1290_passage",
"type": "progene_text",
"text": [
"Fibroblast growth factor-10 ( FGF-10 ) is a stromal - derived paracrine growth factor considered to be important during embryogenesis ; however , its expression by cells in the female reproductive tract has not been investigated ."
],
"offsets": [
[
0,
230
]
]
}
]
| [
{
"id": "split_0_train_1898_entity",
"type": "progene_text",
"text": [
"Fibroblast growth factor-10"
],
"offsets": [
[
0,
27
]
],
"normalized": []
},
{
"id": "split_0_train_1899_entity",
"type": "progene_text",
"text": [
"FGF-10"
],
"offsets": [
[
30,
36
]
],
"normalized": []
},
{
"id": "split_0_train_1900_entity",
"type": "progene_text",
"text": [
"growth factor"
],
"offsets": [
[
72,
85
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1291 | split_0_train_1291 | [
{
"id": "split_0_train_1291_passage",
"type": "progene_text",
"text": [
"Therefore , an ovine FGF-10 cDNA was cloned from an ovine endometrial cDNA library to investigate expression and potential paracrine characteristics of FGF-10 in the ovine uterus ."
],
"offsets": [
[
0,
180
]
]
}
]
| [
{
"id": "split_0_train_1901_entity",
"type": "progene_text",
"text": [
"FGF-10"
],
"offsets": [
[
21,
27
]
],
"normalized": []
},
{
"id": "split_0_train_1902_entity",
"type": "progene_text",
"text": [
"FGF-10"
],
"offsets": [
[
152,
158
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1292 | split_0_train_1292 | [
{
"id": "split_0_train_1292_passage",
"type": "progene_text",
"text": [
"The ovine FGF-10 cDNA encodes a protein of 213 amino acids and possesses an unusually long 5' untranslated region ( UTR ) ."
],
"offsets": [
[
0,
123
]
]
}
]
| [
{
"id": "split_0_train_1903_entity",
"type": "progene_text",
"text": [
"FGF-10"
],
"offsets": [
[
10,
16
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1293 | split_0_train_1293 | [
{
"id": "split_0_train_1293_passage",
"type": "progene_text",
"text": [
"In situ hybridization demonstrated that ovine FGF-10 mRNA was expressed by endometrial stromal cells and by mesenchymal cells of the chorioallantoic placenta ."
],
"offsets": [
[
0,
159
]
]
}
]
| [
{
"id": "split_0_train_1904_entity",
"type": "progene_text",
"text": [
"FGF-10"
],
"offsets": [
[
46,
52
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1294 | split_0_train_1294 | [
{
"id": "split_0_train_1294_passage",
"type": "progene_text",
"text": [
"The mRNA for FGF-7 , a homologue of FGF-10 , was localized in the tunica muscularis of blood vessels in endometrium and myometrium ."
],
"offsets": [
[
0,
132
]
]
}
]
| [
{
"id": "split_0_train_1905_entity",
"type": "progene_text",
"text": [
"FGF-7"
],
"offsets": [
[
13,
18
]
],
"normalized": []
},
{
"id": "split_0_train_1906_entity",
"type": "progene_text",
"text": [
"FGF-10"
],
"offsets": [
[
36,
42
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1295 | split_0_train_1295 | [
{
"id": "split_0_train_1295_passage",
"type": "progene_text",
"text": [
"In contrast , FGF receptor 2IIIb , the high - affinity receptor for both FGF-10 and FGF-7 , was expressed exclusively in luminal epithelium , glandular epithelium , and placental trophectoderm ."
],
"offsets": [
[
0,
194
]
]
}
]
| [
{
"id": "split_0_train_1907_entity",
"type": "progene_text",
"text": [
"FGF receptor 2IIIb"
],
"offsets": [
[
14,
32
]
],
"normalized": []
},
{
"id": "split_0_train_1908_entity",
"type": "progene_text",
"text": [
"FGF-10"
],
"offsets": [
[
73,
79
]
],
"normalized": []
},
{
"id": "split_0_train_1909_entity",
"type": "progene_text",
"text": [
"FGF-7"
],
"offsets": [
[
84,
89
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1296 | split_0_train_1296 | [
{
"id": "split_0_train_1296_passage",
"type": "progene_text",
"text": [
"The in vivo spatial expression pattern suggests that FGF-10 is a novel endometrial stromal cell - derived mediator of uterine epithelial and conceptus trophectodermal functions ."
],
"offsets": [
[
0,
178
]
]
}
]
| [
{
"id": "split_0_train_1910_entity",
"type": "progene_text",
"text": [
"FGF-10"
],
"offsets": [
[
53,
59
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1297 | split_0_train_1297 | [
{
"id": "split_0_train_1297_passage",
"type": "progene_text",
"text": [
"The nonoverlapping spatial patterns of expression for FGF-10 and FGF-7 in ovine uterus and conceptus suggest independent roles in uterine function and conceptus development ."
],
"offsets": [
[
0,
174
]
]
}
]
| [
{
"id": "split_0_train_1911_entity",
"type": "progene_text",
"text": [
"FGF-10"
],
"offsets": [
[
54,
60
]
],
"normalized": []
},
{
"id": "split_0_train_1912_entity",
"type": "progene_text",
"text": [
"FGF-7"
],
"offsets": [
[
65,
70
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1298 | split_0_train_1298 | [
{
"id": "split_0_train_1298_passage",
"type": "progene_text",
"text": [
"Nutritional status and postoperative cytokine response in colorectal cancer patients ."
],
"offsets": [
[
0,
86
]
]
}
]
| [
{
"id": "split_0_train_1913_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
37,
45
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1299 | split_0_train_1299 | [
{
"id": "split_0_train_1299_passage",
"type": "progene_text",
"text": [
"The present study was designed to investigate the relationship between pre - operative nutritional status and peri - operative regulation of the cytokine network , and to clarify its relation to clinical outcome in colorectal cancer patients ."
],
"offsets": [
[
0,
243
]
]
}
]
| [
{
"id": "split_0_train_1914_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
145,
153
]
],
"normalized": []
}
]
| []
| []
| []
|
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