id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
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|---|---|---|---|---|---|---|
split_0_train_1400 | split_0_train_1400 | [
{
"id": "split_0_train_1400_passage",
"type": "progene_text",
"text": [
"Cryptochrome 1 ( cry1 ) , cryptochrome 2 ( cry2 ) and phototropin are the blue / ultraviolet - A light receptors that have been characterized in Arabidopsis ."
],
"offsets": [
[
0,
158
]
]
}
]
| [
{
"id": "split_0_train_2068_entity",
"type": "progene_text",
"text": [
"Cryptochrome 1"
],
"offsets": [
[
0,
14
]
],
"normalized": []
},
{
"id": "split_0_train_2069_entity",
"type": "progene_text",
"text": [
"cry1"
],
"offsets": [
[
17,
21
]
],
"normalized": []
},
{
"id": "split_0_train_2070_entity",
"type": "progene_text",
"text": [
"cryptochrome 2"
],
"offsets": [
[
26,
40
]
],
"normalized": []
},
{
"id": "split_0_train_2071_entity",
"type": "progene_text",
"text": [
"cry2"
],
"offsets": [
[
43,
47
]
],
"normalized": []
},
{
"id": "split_0_train_2072_entity",
"type": "progene_text",
"text": [
"phototropin"
],
"offsets": [
[
54,
65
]
],
"normalized": []
},
{
"id": "split_0_train_2073_entity",
"type": "progene_text",
"text": [
"blue / ultraviolet - A light receptors"
],
"offsets": [
[
74,
112
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1401 | split_0_train_1401 | [
{
"id": "split_0_train_1401_passage",
"type": "progene_text",
"text": [
"Previous studies showed that modulation of many physiological responses in plants is achieved by genetic interactions between different photoreceptors ; however , little is known about the nature of these interactions and their roles in the signal transduction pathway ."
],
"offsets": [
[
0,
270
]
]
}
]
| [
{
"id": "split_0_train_2074_entity",
"type": "progene_text",
"text": [
"photoreceptors"
],
"offsets": [
[
136,
150
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1402 | split_0_train_1402 | [
{
"id": "split_0_train_1402_passage",
"type": "progene_text",
"text": [
"Here we show the genetic interaction that occurs between the Arabidopsis photoreceptors phyB and cry2 in the control of flowering time , hypocotyl elongation and circadian period by the clock ."
],
"offsets": [
[
0,
193
]
]
}
]
| [
{
"id": "split_0_train_2075_entity",
"type": "progene_text",
"text": [
"photoreceptors"
],
"offsets": [
[
73,
87
]
],
"normalized": []
},
{
"id": "split_0_train_2076_entity",
"type": "progene_text",
"text": [
"phyB"
],
"offsets": [
[
88,
92
]
],
"normalized": []
},
{
"id": "split_0_train_2077_entity",
"type": "progene_text",
"text": [
"cry2"
],
"offsets": [
[
97,
101
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1403 | split_0_train_1403 | [
{
"id": "split_0_train_1403_passage",
"type": "progene_text",
"text": [
"PhyB interacts directly with cry2 as observed in co - immunoprecipitation experiments with transgenic Arabidopsis plants overexpressing cry2 ."
],
"offsets": [
[
0,
142
]
]
}
]
| [
{
"id": "split_0_train_2078_entity",
"type": "progene_text",
"text": [
"PhyB"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_2079_entity",
"type": "progene_text",
"text": [
"cry2"
],
"offsets": [
[
29,
33
]
],
"normalized": []
},
{
"id": "split_0_train_2080_entity",
"type": "progene_text",
"text": [
"cry2"
],
"offsets": [
[
136,
140
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1404 | split_0_train_1404 | [
{
"id": "split_0_train_1404_passage",
"type": "progene_text",
"text": [
"Using fluorescent resonance energy transfer microscopy , we show that phyB and cry2 interact in nuclear speckles that are formed in a light - dependent fashion ."
],
"offsets": [
[
0,
161
]
]
}
]
| [
{
"id": "split_0_train_2081_entity",
"type": "progene_text",
"text": [
"phyB"
],
"offsets": [
[
70,
74
]
],
"normalized": []
},
{
"id": "split_0_train_2082_entity",
"type": "progene_text",
"text": [
"cry2"
],
"offsets": [
[
79,
83
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1405 | split_0_train_1405 | [
{
"id": "split_0_train_1405_passage",
"type": "progene_text",
"text": [
"Identification of two putative novel folate receptor genes in humans and mouse ."
],
"offsets": [
[
0,
80
]
]
}
]
| [
{
"id": "split_0_train_2083_entity",
"type": "progene_text",
"text": [
"folate receptor"
],
"offsets": [
[
37,
52
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1406 | split_0_train_1406 | [
{
"id": "split_0_train_1406_passage",
"type": "progene_text",
"text": [
"Utilizing a ' database mining ' strategy to detect novel folate receptors ( FR ) , we identified two potential novel members in the mouse and human ."
],
"offsets": [
[
0,
149
]
]
}
]
| [
{
"id": "split_0_train_2084_entity",
"type": "progene_text",
"text": [
"folate receptors"
],
"offsets": [
[
57,
73
]
],
"normalized": []
},
{
"id": "split_0_train_2085_entity",
"type": "progene_text",
"text": [
"FR"
],
"offsets": [
[
76,
78
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1407 | split_0_train_1407 | [
{
"id": "split_0_train_1407_passage",
"type": "progene_text",
"text": [
"The mouse gene ( Folbp3 ) was sequenced and found to predict a 28.2 kDa protein that consists of 244 amino acids that is highly expressed in both the thymus and spleen , suggesting a potential role in the immune system ."
],
"offsets": [
[
0,
220
]
]
}
]
| [
{
"id": "split_0_train_2086_entity",
"type": "progene_text",
"text": [
"Folbp3"
],
"offsets": [
[
17,
23
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1408 | split_0_train_1408 | [
{
"id": "split_0_train_1408_passage",
"type": "progene_text",
"text": [
"The human gene ( FR - delta ) is mapped to chromosome 11q14 , and predicts a 27.7 kDa protein that is comprised of 241 amino acids ."
],
"offsets": [
[
0,
132
]
]
}
]
| [
{
"id": "split_0_train_2087_entity",
"type": "progene_text",
"text": [
"FR - delta"
],
"offsets": [
[
17,
27
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1409 | split_0_train_1409 | [
{
"id": "split_0_train_1409_passage",
"type": "progene_text",
"text": [
"However , expression of the human gene was not detected in 59 samples from both adult and embryonic tissue sources , suggesting a highly restricted spatial / temporal expression pattern , an alternatively spliced variant or an additional FR pseudogene ."
],
"offsets": [
[
0,
253
]
]
}
]
| [
{
"id": "split_0_train_2088_entity",
"type": "progene_text",
"text": [
"FR pseudogene"
],
"offsets": [
[
238,
251
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1410 | split_0_train_1410 | [
{
"id": "split_0_train_1410_passage",
"type": "progene_text",
"text": [
"Using T31 mouse radiation hybrid mapping , Folbp3 was mapped to a region on mouse chromosome 9 that is syntenic to human chromosome 19p13 ."
],
"offsets": [
[
0,
139
]
]
}
]
| [
{
"id": "split_0_train_2089_entity",
"type": "progene_text",
"text": [
"Folbp3"
],
"offsets": [
[
43,
49
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1411 | split_0_train_1411 | [
{
"id": "split_0_train_1411_passage",
"type": "progene_text",
"text": [
"As the chromosomal locations of Folbp1 murine and Folbp2 genes were previously unknown , we utilized the same approach and mapped both genes to a region of mouse chromosome 7 that is syntenic to the human FR loci on chromosome 11q13 ."
],
"offsets": [
[
0,
234
]
]
}
]
| [
{
"id": "split_0_train_2090_entity",
"type": "progene_text",
"text": [
"Folbp1"
],
"offsets": [
[
32,
38
]
],
"normalized": []
},
{
"id": "split_0_train_2091_entity",
"type": "progene_text",
"text": [
"Folbp2"
],
"offsets": [
[
50,
56
]
],
"normalized": []
},
{
"id": "split_0_train_2092_entity",
"type": "progene_text",
"text": [
"FR"
],
"offsets": [
[
205,
207
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1412 | split_0_train_1412 | [
{
"id": "split_0_train_1412_passage",
"type": "progene_text",
"text": [
"Adhesion of fibronectin , vitronectin , laminin , and collagen type IV to intraocular lens materials in pseudophakic human autopsy eyes ."
],
"offsets": [
[
0,
137
]
]
}
]
| [
{
"id": "split_0_train_2093_entity",
"type": "progene_text",
"text": [
"fibronectin"
],
"offsets": [
[
12,
23
]
],
"normalized": []
},
{
"id": "split_0_train_2094_entity",
"type": "progene_text",
"text": [
"vitronectin"
],
"offsets": [
[
26,
37
]
],
"normalized": []
},
{
"id": "split_0_train_2095_entity",
"type": "progene_text",
"text": [
"laminin"
],
"offsets": [
[
40,
47
]
],
"normalized": []
},
{
"id": "split_0_train_2096_entity",
"type": "progene_text",
"text": [
"collagen type IV"
],
"offsets": [
[
54,
70
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1413 | split_0_train_1413 | [
{
"id": "split_0_train_1413_passage",
"type": "progene_text",
"text": [
"Part 1 : histological sections ."
],
"offsets": [
[
0,
32
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1414 | split_0_train_1414 | [
{
"id": "split_0_train_1414_passage",
"type": "progene_text",
"text": [
"PURPOSE :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1415 | split_0_train_1415 | [
{
"id": "split_0_train_1415_passage",
"type": "progene_text",
"text": [
"To evaluate fibronectin , vitronectin , laminin , and collagen type IV adhesion to poly ( methyl methacrylate ) ( PMMA ) , silicone , hydrophobic soft acrylate , and hydrogel intraocular lenses ( IOLs ) in pseudophakic human autopsy eyes ."
],
"offsets": [
[
0,
239
]
]
}
]
| [
{
"id": "split_0_train_2097_entity",
"type": "progene_text",
"text": [
"fibronectin"
],
"offsets": [
[
12,
23
]
],
"normalized": []
},
{
"id": "split_0_train_2098_entity",
"type": "progene_text",
"text": [
"vitronectin"
],
"offsets": [
[
26,
37
]
],
"normalized": []
},
{
"id": "split_0_train_2099_entity",
"type": "progene_text",
"text": [
"laminin"
],
"offsets": [
[
40,
47
]
],
"normalized": []
},
{
"id": "split_0_train_2100_entity",
"type": "progene_text",
"text": [
"collagen type IV"
],
"offsets": [
[
54,
70
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1416 | split_0_train_1416 | [
{
"id": "split_0_train_1416_passage",
"type": "progene_text",
"text": [
"SETTING :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1417 | split_0_train_1417 | [
{
"id": "split_0_train_1417_passage",
"type": "progene_text",
"text": [
"Center for Research on Ocular Therapeutics and Biodevices , Storm Eye Institute , Medical University of South Carolina , Charleston , South Carolina , USA ."
],
"offsets": [
[
0,
156
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1418 | split_0_train_1418 | [
{
"id": "split_0_train_1418_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1419 | split_0_train_1419 | [
{
"id": "split_0_train_1419_passage",
"type": "progene_text",
"text": [
"Thirty-eight autopsy eyes containing PMMA , silicone , hydrophobic acrylate , or hydrogel IOLs were assessed ."
],
"offsets": [
[
0,
110
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1420 | split_0_train_1420 | [
{
"id": "split_0_train_1420_passage",
"type": "progene_text",
"text": [
"Histological sections were prepared from each eye , and immunohistochemical analyses were performed for fibronectin , vitronectin , laminin , and collagen type IV ."
],
"offsets": [
[
0,
164
]
]
}
]
| [
{
"id": "split_0_train_2101_entity",
"type": "progene_text",
"text": [
"fibronectin"
],
"offsets": [
[
104,
115
]
],
"normalized": []
},
{
"id": "split_0_train_2102_entity",
"type": "progene_text",
"text": [
"vitronectin"
],
"offsets": [
[
118,
129
]
],
"normalized": []
},
{
"id": "split_0_train_2103_entity",
"type": "progene_text",
"text": [
"laminin"
],
"offsets": [
[
132,
139
]
],
"normalized": []
},
{
"id": "split_0_train_2104_entity",
"type": "progene_text",
"text": [
"collagen type IV"
],
"offsets": [
[
146,
162
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1421 | split_0_train_1421 | [
{
"id": "split_0_train_1421_passage",
"type": "progene_text",
"text": [
"One hundred fifty-two specimens were analyzed ."
],
"offsets": [
[
0,
47
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1422 | split_0_train_1422 | [
{
"id": "split_0_train_1422_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1423 | split_0_train_1423 | [
{
"id": "split_0_train_1423_passage",
"type": "progene_text",
"text": [
"A sandwich - like structure ( anterior or posterior capsule / fibronectin / 1 cell layer / fibronectin / IOL surface ) was seen in 12 of 14 autopsy eyes with soft acrylate IOLs , 3 of 10 with a PMMA IOL ( P = .0094 ) , 1 of 10 with a silicone IOL ( P = .0022 ) , and 0 of 4 with a hydrogel IOL ( P = . 0041 ) ."
],
"offsets": [
[
0,
310
]
]
}
]
| [
{
"id": "split_0_train_2105_entity",
"type": "progene_text",
"text": [
"fibronectin"
],
"offsets": [
[
62,
73
]
],
"normalized": []
},
{
"id": "split_0_train_2106_entity",
"type": "progene_text",
"text": [
"fibronectin"
],
"offsets": [
[
91,
102
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1424 | split_0_train_1424 | [
{
"id": "split_0_train_1424_passage",
"type": "progene_text",
"text": [
"The thicker fibrocellular tissue on the inner surface of the anterior or posterior capsule that was in contact with silicone IOLs was lined with collagen type IV ."
],
"offsets": [
[
0,
163
]
]
}
]
| [
{
"id": "split_0_train_2107_entity",
"type": "progene_text",
"text": [
"collagen type IV"
],
"offsets": [
[
145,
161
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1425 | split_0_train_1425 | [
{
"id": "split_0_train_1425_passage",
"type": "progene_text",
"text": [
"Vitronectin and laminin were not found at the fibrocellular tissue - IOL interface in any specimen ."
],
"offsets": [
[
0,
100
]
]
}
]
| [
{
"id": "split_0_train_2108_entity",
"type": "progene_text",
"text": [
"Vitronectin"
],
"offsets": [
[
0,
11
]
],
"normalized": []
},
{
"id": "split_0_train_2109_entity",
"type": "progene_text",
"text": [
"laminin"
],
"offsets": [
[
16,
23
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1426 | split_0_train_1426 | [
{
"id": "split_0_train_1426_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1427 | split_0_train_1427 | [
{
"id": "split_0_train_1427_passage",
"type": "progene_text",
"text": [
"This study seems to confirm the sandwich theory of posterior capsule opacification in eyes with an IOL and suggests that fibronectin may be the major extracellular protein responsible for the attachment of hydrophobic soft acrylate ( AcrySof(R) ) IOLs to the capsular bag ."
],
"offsets": [
[
0,
273
]
]
}
]
| [
{
"id": "split_0_train_2110_entity",
"type": "progene_text",
"text": [
"fibronectin"
],
"offsets": [
[
121,
132
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1428 | split_0_train_1428 | [
{
"id": "split_0_train_1428_passage",
"type": "progene_text",
"text": [
"This may represent a true bioactive bond between the IOL and lens epithelial cells or between the IOL and the capsular bag and may be one reason the PCO and neodymium : YAG capsulotomy rates are lower in eyes with a soft acrylate IOL ."
],
"offsets": [
[
0,
235
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1429 | split_0_train_1429 | [
{
"id": "split_0_train_1429_passage",
"type": "progene_text",
"text": [
"Nerve control of type 2A MHC isoform expression in regenerating slow skeletal muscle ."
],
"offsets": [
[
0,
86
]
]
}
]
| [
{
"id": "split_0_train_2111_entity",
"type": "progene_text",
"text": [
"type 2A MHC"
],
"offsets": [
[
17,
28
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1430 | split_0_train_1430 | [
{
"id": "split_0_train_1430_passage",
"type": "progene_text",
"text": [
"Bupivacaine - induced regeneration was studied in rat soleus muscle under several conditions , with the focus on type 2A and type 1 myosin heavy chain ( MHC ) isoform expression ."
],
"offsets": [
[
0,
179
]
]
}
]
| [
{
"id": "split_0_train_2112_entity",
"type": "progene_text",
"text": [
"type 2A and type 1 myosin heavy chain"
],
"offsets": [
[
113,
150
]
],
"normalized": []
},
{
"id": "split_0_train_2113_entity",
"type": "progene_text",
"text": [
"MHC"
],
"offsets": [
[
153,
156
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1431 | split_0_train_1431 | [
{
"id": "split_0_train_1431_passage",
"type": "progene_text",
"text": [
"In denervated muscles , type 1 was absent , whereas type 2A was widely expressed , a pattern of regeneration which appeared to be independent of fibrillation activity of the muscle ."
],
"offsets": [
[
0,
182
]
]
}
]
| [
{
"id": "split_0_train_2114_entity",
"type": "progene_text",
"text": [
"2A"
],
"offsets": [
[
57,
59
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1432 | split_0_train_1432 | [
{
"id": "split_0_train_1432_passage",
"type": "progene_text",
"text": [
"Both type 1 and type 2A isoforms were absent in muscles regenerated during tetrodotoxin ( TTX ) block of impulse conduction in the sciatic nerve , but type 2A was still present when the TTX block was associated with the vinblastine block of axoplasmic flow ; vinblastine block alone caused the coexpression of type 1 and type 2A isoforms in the majority of fibers ."
],
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[
0,
365
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]
}
]
| [
{
"id": "split_0_train_2115_entity",
"type": "progene_text",
"text": [
"2A"
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[
21,
23
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},
{
"id": "split_0_train_2116_entity",
"type": "progene_text",
"text": [
"2A"
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156,
158
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},
{
"id": "split_0_train_2117_entity",
"type": "progene_text",
"text": [
"2A"
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[
326,
328
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1433 | split_0_train_1433 | [
{
"id": "split_0_train_1433_passage",
"type": "progene_text",
"text": [
"These results suggest that axoplasmic flow carries some chemical factor that inhibits 2A MHC isoform expression ."
],
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[
0,
113
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]
}
]
| [
{
"id": "split_0_train_2118_entity",
"type": "progene_text",
"text": [
"2A MHC"
],
"offsets": [
[
86,
92
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1434 | split_0_train_1434 | [
{
"id": "split_0_train_1434_passage",
"type": "progene_text",
"text": [
"The results are also of clinical interest , contributing to the understanding of factors controlling muscle differentiation and adaptation ."
],
"offsets": [
[
0,
140
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1435 | split_0_train_1435 | [
{
"id": "split_0_train_1435_passage",
"type": "progene_text",
"text": [
"Antigen - specific mediated suppression of beta cell autoimmunity by plasmid DNA vaccination ."
],
"offsets": [
[
0,
94
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1436 | split_0_train_1436 | [
{
"id": "split_0_train_1436_passage",
"type": "progene_text",
"text": [
"In this study , we have investigated the use of plasmid DNA ( pDNA ) vaccination to elicit Th2 effector cell function in an Ag - specific manner and in turn prevent insulin - dependent diabetes mellitus ( IDDM ) in nonobese diabetic ( NOD ) mice ."
],
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[
0,
247
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]
}
]
| [
{
"id": "split_0_train_2119_entity",
"type": "progene_text",
"text": [
"insulin"
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[
165,
172
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1437 | split_0_train_1437 | [
{
"id": "split_0_train_1437_passage",
"type": "progene_text",
"text": [
"pDNA recombinants were engineered encoding a secreted fusion protein consisting of a fragment of glutamic acid decarboxylase 65 ( GAD65 ) linked to IgGFc , and IL-4 ."
],
"offsets": [
[
0,
166
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]
}
]
| [
{
"id": "split_0_train_2120_entity",
"type": "progene_text",
"text": [
"glutamic acid decarboxylase 65"
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[
97,
127
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},
{
"id": "split_0_train_2121_entity",
"type": "progene_text",
"text": [
"GAD65"
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[
130,
135
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},
{
"id": "split_0_train_2122_entity",
"type": "progene_text",
"text": [
"IgGFc"
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[
148,
153
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},
{
"id": "split_0_train_2123_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
160,
164
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1438 | split_0_train_1438 | [
{
"id": "split_0_train_1438_passage",
"type": "progene_text",
"text": [
"Intramuscular injection of pDNA encoding GAD65 - IgGFc and IL-4 effectively prevented diabetes in NOD mice treated at early or late preclinical stages of IDDM ."
],
"offsets": [
[
0,
160
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]
}
]
| [
{
"id": "split_0_train_2124_entity",
"type": "progene_text",
"text": [
"GAD65"
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[
41,
46
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},
{
"id": "split_0_train_2125_entity",
"type": "progene_text",
"text": [
"IgGFc"
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[
49,
54
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},
{
"id": "split_0_train_2126_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
59,
63
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1439 | split_0_train_1439 | [
{
"id": "split_0_train_1439_passage",
"type": "progene_text",
"text": [
"This protection was GAD65 - specific since NOD mice immunized with pDNA encoding hen egg lysozyme - IgGFc and IL-4 continued to develop diabetes ."
],
"offsets": [
[
0,
146
]
]
}
]
| [
{
"id": "split_0_train_2127_entity",
"type": "progene_text",
"text": [
"GAD65"
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"offsets": [
[
20,
25
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],
"normalized": []
},
{
"id": "split_0_train_2128_entity",
"type": "progene_text",
"text": [
"lysozyme"
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"offsets": [
[
89,
97
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],
"normalized": []
},
{
"id": "split_0_train_2129_entity",
"type": "progene_text",
"text": [
"IgGFc"
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"offsets": [
[
100,
105
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],
"normalized": []
},
{
"id": "split_0_train_2130_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
110,
114
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1440 | split_0_train_1440 | [
{
"id": "split_0_train_1440_passage",
"type": "progene_text",
"text": [
"Furthermore , disease prevention correlated with suppression of insulitis and induction of GAD65 - specific regulatory Th2 cells ."
],
"offsets": [
[
0,
130
]
]
}
]
| [
{
"id": "split_0_train_2131_entity",
"type": "progene_text",
"text": [
"GAD65"
],
"offsets": [
[
91,
96
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1441 | split_0_train_1441 | [
{
"id": "split_0_train_1441_passage",
"type": "progene_text",
"text": [
"Importantly , GAD65 - specific immune deviation was dependent on pDNA - encoded IL-4 ."
],
"offsets": [
[
0,
86
]
]
}
]
| [
{
"id": "split_0_train_2132_entity",
"type": "progene_text",
"text": [
"GAD65"
],
"offsets": [
[
14,
19
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],
"normalized": []
},
{
"id": "split_0_train_2133_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
80,
84
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1442 | split_0_train_1442 | [
{
"id": "split_0_train_1442_passage",
"type": "progene_text",
"text": [
"In fact , GAD65 - specific Th1 cell reactivity was significantly enhanced in animals immunized with pDNA encoding only GAD65 - IgGFc ."
],
"offsets": [
[
0,
134
]
]
}
]
| [
{
"id": "split_0_train_2134_entity",
"type": "progene_text",
"text": [
"GAD65"
],
"offsets": [
[
10,
15
]
],
"normalized": []
},
{
"id": "split_0_train_2135_entity",
"type": "progene_text",
"text": [
"GAD65"
],
"offsets": [
[
119,
124
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],
"normalized": []
},
{
"id": "split_0_train_2136_entity",
"type": "progene_text",
"text": [
"IgGFc"
],
"offsets": [
[
127,
132
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1443 | split_0_train_1443 | [
{
"id": "split_0_train_1443_passage",
"type": "progene_text",
"text": [
"Finally , NOD . IL4 ( null ) mice treated with pDNA encoding GAD65 - IgGFc and IL-4 continued to develop diabetes , indicating that endogenous IL-4 was also required for disease prevention ."
],
"offsets": [
[
0,
190
]
]
}
]
| [
{
"id": "split_0_train_2137_entity",
"type": "progene_text",
"text": [
"IL4"
],
"offsets": [
[
16,
19
]
],
"normalized": []
},
{
"id": "split_0_train_2138_entity",
"type": "progene_text",
"text": [
"GAD65"
],
"offsets": [
[
61,
66
]
],
"normalized": []
},
{
"id": "split_0_train_2139_entity",
"type": "progene_text",
"text": [
"IgGFc"
],
"offsets": [
[
69,
74
]
],
"normalized": []
},
{
"id": "split_0_train_2140_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
79,
83
]
],
"normalized": []
},
{
"id": "split_0_train_2141_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
143,
147
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1444 | split_0_train_1444 | [
{
"id": "split_0_train_1444_passage",
"type": "progene_text",
"text": [
"These results demonstrate that pDNA vaccination is an effective strategy to elicit beta cell - specific Th2 regulatory cell function for the purpose of preventing IDDM even at a late stage of disease development ."
],
"offsets": [
[
0,
213
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1445 | split_0_train_1445 | [
{
"id": "split_0_train_1445_passage",
"type": "progene_text",
"text": [
"Interleukin-6 and transforming growth factor - beta 1 control expression of cathepsins B and L in human lung epithelial cells ."
],
"offsets": [
[
0,
127
]
]
}
]
| [
{
"id": "split_0_train_2142_entity",
"type": "progene_text",
"text": [
"Interleukin-6"
],
"offsets": [
[
0,
13
]
],
"normalized": []
},
{
"id": "split_0_train_2143_entity",
"type": "progene_text",
"text": [
"transforming growth factor - beta 1"
],
"offsets": [
[
18,
53
]
],
"normalized": []
},
{
"id": "split_0_train_2144_entity",
"type": "progene_text",
"text": [
"cathepsins B and L"
],
"offsets": [
[
76,
94
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1446 | split_0_train_1446 | [
{
"id": "split_0_train_1446_passage",
"type": "progene_text",
"text": [
"Cathepsins B and L are commonly expressed cysteine proteinases that play a major role in lysosomal bulk proteolysis , protein processing , matrix degradation , and tissue remodeling ."
],
"offsets": [
[
0,
183
]
]
}
]
| [
{
"id": "split_0_train_2145_entity",
"type": "progene_text",
"text": [
"Cathepsins B and L"
],
"offsets": [
[
0,
18
]
],
"normalized": []
},
{
"id": "split_0_train_2146_entity",
"type": "progene_text",
"text": [
"cysteine proteinases"
],
"offsets": [
[
42,
62
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1447 | split_0_train_1447 | [
{
"id": "split_0_train_1447_passage",
"type": "progene_text",
"text": [
"Cathepsins are also implicated in tumor progression and metastasis , tissue injury , and inflammation ."
],
"offsets": [
[
0,
103
]
]
}
]
| [
{
"id": "split_0_train_2147_entity",
"type": "progene_text",
"text": [
"Cathepsins"
],
"offsets": [
[
0,
10
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1448 | split_0_train_1448 | [
{
"id": "split_0_train_1448_passage",
"type": "progene_text",
"text": [
"Cells at sites of inflammation often show upregulation and secretion of cathepsins ."
],
"offsets": [
[
0,
84
]
]
}
]
| [
{
"id": "split_0_train_2148_entity",
"type": "progene_text",
"text": [
"cathepsins"
],
"offsets": [
[
72,
82
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1449 | split_0_train_1449 | [
{
"id": "split_0_train_1449_passage",
"type": "progene_text",
"text": [
"The regulation of cathepsin expression by inflammatory mediators is not well understood ."
],
"offsets": [
[
0,
89
]
]
}
]
| [
{
"id": "split_0_train_2149_entity",
"type": "progene_text",
"text": [
"cathepsin"
],
"offsets": [
[
18,
27
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1450 | split_0_train_1450 | [
{
"id": "split_0_train_1450_passage",
"type": "progene_text",
"text": [
"The aims of this study were to investigate the effect of the cytokines interleukin-1 beta ( IL-1 beta ) , IL-6 , IL-10 , transforming growth factor - beta 1 ( TGF-beta 1 ) , and hepatocyte growth factor ( HGF ) on expression of cathepsin B and cathepsin L mRNA ( quantitative RT - PCR ) , on protein expression ( ELISA , Western blot ) , and also on enzymatic activity of cathepsins B and L ."
],
"offsets": [
[
0,
392
]
]
}
]
| [
{
"id": "split_0_train_2150_entity",
"type": "progene_text",
"text": [
"cytokines"
],
"offsets": [
[
61,
70
]
],
"normalized": []
},
{
"id": "split_0_train_2151_entity",
"type": "progene_text",
"text": [
"interleukin-1 beta"
],
"offsets": [
[
71,
89
]
],
"normalized": []
},
{
"id": "split_0_train_2152_entity",
"type": "progene_text",
"text": [
"IL-1 beta"
],
"offsets": [
[
92,
101
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],
"normalized": []
},
{
"id": "split_0_train_2153_entity",
"type": "progene_text",
"text": [
"IL-6"
],
"offsets": [
[
106,
110
]
],
"normalized": []
},
{
"id": "split_0_train_2154_entity",
"type": "progene_text",
"text": [
"IL-10"
],
"offsets": [
[
113,
118
]
],
"normalized": []
},
{
"id": "split_0_train_2155_entity",
"type": "progene_text",
"text": [
"transforming growth factor - beta 1"
],
"offsets": [
[
121,
156
]
],
"normalized": []
},
{
"id": "split_0_train_2156_entity",
"type": "progene_text",
"text": [
"TGF-beta 1"
],
"offsets": [
[
159,
169
]
],
"normalized": []
},
{
"id": "split_0_train_2157_entity",
"type": "progene_text",
"text": [
"hepatocyte growth factor"
],
"offsets": [
[
178,
202
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],
"normalized": []
},
{
"id": "split_0_train_2158_entity",
"type": "progene_text",
"text": [
"HGF"
],
"offsets": [
[
205,
208
]
],
"normalized": []
},
{
"id": "split_0_train_2159_entity",
"type": "progene_text",
"text": [
"cathepsin B"
],
"offsets": [
[
228,
239
]
],
"normalized": []
},
{
"id": "split_0_train_2160_entity",
"type": "progene_text",
"text": [
"cathepsin L"
],
"offsets": [
[
244,
255
]
],
"normalized": []
},
{
"id": "split_0_train_2161_entity",
"type": "progene_text",
"text": [
"cathepsins B and L"
],
"offsets": [
[
372,
390
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1451 | split_0_train_1451 | [
{
"id": "split_0_train_1451_passage",
"type": "progene_text",
"text": [
"Investigations were performed using the human lung epithelial cell line A-549 ."
],
"offsets": [
[
0,
79
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1452 | split_0_train_1452 | [
{
"id": "split_0_train_1452_passage",
"type": "progene_text",
"text": [
"IL-6 was found to induce a concentration - dependent increase in mRNA expression , protein concentration , and enzymatic activity of cathepsin L ."
],
"offsets": [
[
0,
146
]
]
}
]
| [
{
"id": "split_0_train_2162_entity",
"type": "progene_text",
"text": [
"IL-6"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_2163_entity",
"type": "progene_text",
"text": [
"cathepsin L"
],
"offsets": [
[
133,
144
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1453 | split_0_train_1453 | [
{
"id": "split_0_train_1453_passage",
"type": "progene_text",
"text": [
"Cathepsin B mRNA and protein expression were not affected by IL-6 ."
],
"offsets": [
[
0,
67
]
]
}
]
| [
{
"id": "split_0_train_2164_entity",
"type": "progene_text",
"text": [
"Cathepsin B"
],
"offsets": [
[
0,
11
]
],
"normalized": []
},
{
"id": "split_0_train_2165_entity",
"type": "progene_text",
"text": [
"IL-6"
],
"offsets": [
[
61,
65
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1454 | split_0_train_1454 | [
{
"id": "split_0_train_1454_passage",
"type": "progene_text",
"text": [
"In contrast , TGF-beta 1 decreased the amount of cathepsin L mRNA and cathepsin B mRNA ."
],
"offsets": [
[
0,
88
]
]
}
]
| [
{
"id": "split_0_train_2166_entity",
"type": "progene_text",
"text": [
"TGF-beta 1"
],
"offsets": [
[
14,
24
]
],
"normalized": []
},
{
"id": "split_0_train_2167_entity",
"type": "progene_text",
"text": [
"cathepsin L"
],
"offsets": [
[
49,
60
]
],
"normalized": []
},
{
"id": "split_0_train_2168_entity",
"type": "progene_text",
"text": [
"cathepsin B"
],
"offsets": [
[
70,
81
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1455 | split_0_train_1455 | [
{
"id": "split_0_train_1455_passage",
"type": "progene_text",
"text": [
"At protein level , it was shown that TGF-beta 1 clearly reduced the concentration of cathepsin L but not cathepsin B ."
],
"offsets": [
[
0,
118
]
]
}
]
| [
{
"id": "split_0_train_2169_entity",
"type": "progene_text",
"text": [
"TGF-beta 1"
],
"offsets": [
[
37,
47
]
],
"normalized": []
},
{
"id": "split_0_train_2170_entity",
"type": "progene_text",
"text": [
"cathepsin L"
],
"offsets": [
[
85,
96
]
],
"normalized": []
},
{
"id": "split_0_train_2171_entity",
"type": "progene_text",
"text": [
"cathepsin B"
],
"offsets": [
[
105,
116
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1456 | split_0_train_1456 | [
{
"id": "split_0_train_1456_passage",
"type": "progene_text",
"text": [
"The cytokines IL-1 beta , IL-10 , and HGF were found to exert no effect on cathepsin B and L expression ."
],
"offsets": [
[
0,
105
]
]
}
]
| [
{
"id": "split_0_train_2172_entity",
"type": "progene_text",
"text": [
"cytokines"
],
"offsets": [
[
4,
13
]
],
"normalized": []
},
{
"id": "split_0_train_2173_entity",
"type": "progene_text",
"text": [
"IL-1 beta"
],
"offsets": [
[
14,
23
]
],
"normalized": []
},
{
"id": "split_0_train_2174_entity",
"type": "progene_text",
"text": [
"IL-10"
],
"offsets": [
[
26,
31
]
],
"normalized": []
},
{
"id": "split_0_train_2175_entity",
"type": "progene_text",
"text": [
"HGF"
],
"offsets": [
[
38,
41
]
],
"normalized": []
},
{
"id": "split_0_train_2176_entity",
"type": "progene_text",
"text": [
"cathepsin B and L"
],
"offsets": [
[
75,
92
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1457 | split_0_train_1457 | [
{
"id": "split_0_train_1457_passage",
"type": "progene_text",
"text": [
"In conclusion , these results are the first to show that IL-6 and TGF-beta 1 have opposite effects on the regulation of expression of cathepsins B and L in A-549 human lung epithelial cells ."
],
"offsets": [
[
0,
191
]
]
}
]
| [
{
"id": "split_0_train_2177_entity",
"type": "progene_text",
"text": [
"IL-6"
],
"offsets": [
[
57,
61
]
],
"normalized": []
},
{
"id": "split_0_train_2178_entity",
"type": "progene_text",
"text": [
"TGF-beta 1"
],
"offsets": [
[
66,
76
]
],
"normalized": []
},
{
"id": "split_0_train_2179_entity",
"type": "progene_text",
"text": [
"cathepsins B and L"
],
"offsets": [
[
134,
152
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1458 | split_0_train_1458 | [
{
"id": "split_0_train_1458_passage",
"type": "progene_text",
"text": [
"The proinflammatory cytokine IL-6 induced an upregulation of cathepsin L , whereas TGF-beta 1 suppressed cathepsin B and L expression ."
],
"offsets": [
[
0,
135
]
]
}
]
| [
{
"id": "split_0_train_2180_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
20,
28
]
],
"normalized": []
},
{
"id": "split_0_train_2181_entity",
"type": "progene_text",
"text": [
"IL-6"
],
"offsets": [
[
29,
33
]
],
"normalized": []
},
{
"id": "split_0_train_2182_entity",
"type": "progene_text",
"text": [
"cathepsin L"
],
"offsets": [
[
61,
72
]
],
"normalized": []
},
{
"id": "split_0_train_2183_entity",
"type": "progene_text",
"text": [
"TGF-beta 1"
],
"offsets": [
[
83,
93
]
],
"normalized": []
},
{
"id": "split_0_train_2184_entity",
"type": "progene_text",
"text": [
"cathepsin B and L"
],
"offsets": [
[
105,
122
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1459 | split_0_train_1459 | [
{
"id": "split_0_train_1459_passage",
"type": "progene_text",
"text": [
"Further studies are needed to clarify the mechanism that affects cathepsin B and L expression ."
],
"offsets": [
[
0,
95
]
]
}
]
| [
{
"id": "split_0_train_2185_entity",
"type": "progene_text",
"text": [
"cathepsin B and L"
],
"offsets": [
[
65,
82
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1460 | split_0_train_1460 | [
{
"id": "split_0_train_1460_passage",
"type": "progene_text",
"text": [
"Ku autoantigen ( DNA helicase ) is required for interleukins - 13 / - 4 - induction of 15-lipoxygenase-1 gene expression in human epithelial cells ."
],
"offsets": [
[
0,
148
]
]
}
]
| [
{
"id": "split_0_train_2186_entity",
"type": "progene_text",
"text": [
"Ku autoantigen"
],
"offsets": [
[
0,
14
]
],
"normalized": []
},
{
"id": "split_0_train_2187_entity",
"type": "progene_text",
"text": [
"DNA helicase"
],
"offsets": [
[
17,
29
]
],
"normalized": []
},
{
"id": "split_0_train_2188_entity",
"type": "progene_text",
"text": [
"interleukins - 13 / - 4"
],
"offsets": [
[
48,
71
]
],
"normalized": []
},
{
"id": "split_0_train_2189_entity",
"type": "progene_text",
"text": [
"15-lipoxygenase-1"
],
"offsets": [
[
87,
104
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1461 | split_0_train_1461 | [
{
"id": "split_0_train_1461_passage",
"type": "progene_text",
"text": [
"As reported previously in human monocytes , a human lung epithelial cell line , A549 , showed de novo induction of 15-Lipoxygenase-1 ( 15-LO-1 ) in response to interleukins - 13 ( IL-13 ) and - 4 ( IL-4 ) ."
],
"offsets": [
[
0,
206
]
]
}
]
| [
{
"id": "split_0_train_2190_entity",
"type": "progene_text",
"text": [
"15-Lipoxygenase-1"
],
"offsets": [
[
115,
132
]
],
"normalized": []
},
{
"id": "split_0_train_2191_entity",
"type": "progene_text",
"text": [
"15-LO-1"
],
"offsets": [
[
135,
142
]
],
"normalized": []
},
{
"id": "split_0_train_2192_entity",
"type": "progene_text",
"text": [
"interleukins - 13 ( IL-13 ) and - 4"
],
"offsets": [
[
160,
195
]
],
"normalized": []
},
{
"id": "split_0_train_2193_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
198,
202
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1462 | split_0_train_1462 | [
{
"id": "split_0_train_1462_passage",
"type": "progene_text",
"text": [
"In this cell line , 15-LO-1 expression , by RT - PCR and western blotting , was observed following 6 and 24 h of exposure to human IL-13 ( ED50 5 ng / ml ) and IL-4 ( ED50 0.2 ng / ml ) ."
],
"offsets": [
[
0,
187
]
]
}
]
| [
{
"id": "split_0_train_2194_entity",
"type": "progene_text",
"text": [
"15-LO-1"
],
"offsets": [
[
20,
27
]
],
"normalized": []
},
{
"id": "split_0_train_2195_entity",
"type": "progene_text",
"text": [
"IL-13"
],
"offsets": [
[
131,
136
]
],
"normalized": []
},
{
"id": "split_0_train_2196_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
160,
164
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1463 | split_0_train_1463 | [
{
"id": "split_0_train_1463_passage",
"type": "progene_text",
"text": [
"We have previously shown that no cis - acting regulatory elements exist within the 15-LO-1 promoter region ."
],
"offsets": [
[
0,
108
]
]
}
]
| [
{
"id": "split_0_train_2197_entity",
"type": "progene_text",
"text": [
"15-LO-1"
],
"offsets": [
[
83,
90
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1464 | split_0_train_1464 | [
{
"id": "split_0_train_1464_passage",
"type": "progene_text",
"text": [
"To define IL-13 and IL-4 responsive trans - acting elements , we identified a region ( DP2 : - 353 to - 304 bp site ) within the 15-LO-1 promoter ( by footprinting experiments ) to which IL-13 - responsive elements ( or factors ) bind specifically ( Kelavkar et al , 1998 , Mol Biol Rep 25 , 173 - 182 ) ."
],
"offsets": [
[
0,
305
]
]
}
]
| [
{
"id": "split_0_train_2198_entity",
"type": "progene_text",
"text": [
"IL-13"
],
"offsets": [
[
10,
15
]
],
"normalized": []
},
{
"id": "split_0_train_2199_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
20,
24
]
],
"normalized": []
},
{
"id": "split_0_train_2200_entity",
"type": "progene_text",
"text": [
"15-LO-1"
],
"offsets": [
[
129,
136
]
],
"normalized": []
},
{
"id": "split_0_train_2201_entity",
"type": "progene_text",
"text": [
"IL-13"
],
"offsets": [
[
187,
192
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1465 | split_0_train_1465 | [
{
"id": "split_0_train_1465_passage",
"type": "progene_text",
"text": [
"To further delineate this region , we constructed ( by site - directed mutagenesis ) several deletion mutants in the ' LOPB5 ' region containing the 29 bp within the - 353 to - 304 bp of the DP2 core element ."
],
"offsets": [
[
0,
209
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1466 | split_0_train_1466 | [
{
"id": "split_0_train_1466_passage",
"type": "progene_text",
"text": [
"These were : DP3 ( site totally deleted ) , DP4 ( 5 bp deleted at the center of the site ) , DP5 ( 8 bp at the 5'-end of the site ) and DP6 ( 13 bp at the 3' - end of the site ) ."
],
"offsets": [
[
0,
179
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1467 | split_0_train_1467 | [
{
"id": "split_0_train_1467_passage",
"type": "progene_text",
"text": [
"Cotransfection of these deletion constructs ( driving luciferase reporter genes ) was associated with 90 % ( DP4 , DP5 and DP6 ) or 100 % ( DP3 ) abrogation of promoter activity at 24 h ."
],
"offsets": [
[
0,
187
]
]
}
]
| [
{
"id": "split_0_train_2202_entity",
"type": "progene_text",
"text": [
"luciferase"
],
"offsets": [
[
54,
64
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1468 | split_0_train_1468 | [
{
"id": "split_0_train_1468_passage",
"type": "progene_text",
"text": [
"Purification of nuclear protein extracts from IL-13 and IL-4 - stimulated A549 cells , using a DP2 core containing affinity column , identified a 150 kDa protein under non - denaturing conditions , and two , 70 and 85 kDa proteins under denaturing conditions ."
],
"offsets": [
[
0,
260
]
]
}
]
| [
{
"id": "split_0_train_2203_entity",
"type": "progene_text",
"text": [
"IL-13"
],
"offsets": [
[
46,
51
]
],
"normalized": []
},
{
"id": "split_0_train_2204_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
56,
60
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1469 | split_0_train_1469 | [
{
"id": "split_0_train_1469_passage",
"type": "progene_text",
"text": [
"These were not detectable by Coomassie blue staining in control nuclear protein extracts ."
],
"offsets": [
[
0,
90
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1470 | split_0_train_1470 | [
{
"id": "split_0_train_1470_passage",
"type": "progene_text",
"text": [
"Matrix assisted laser desorption ionization mass spectrometry ( MALDI - MS ) of the tryptic digests of these proteins , identified one as the 86 kDA Lupus KU autoantigen protein P86 and the second as the 70 kDa Lupus KU autoantigen protein P70 ."
],
"offsets": [
[
0,
245
]
]
}
]
| [
{
"id": "split_0_train_2205_entity",
"type": "progene_text",
"text": [
"86 kDA Lupus KU autoantigen protein P86"
],
"offsets": [
[
142,
181
]
],
"normalized": []
},
{
"id": "split_0_train_2206_entity",
"type": "progene_text",
"text": [
"70 kDa Lupus KU autoantigen protein P70"
],
"offsets": [
[
204,
243
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1471 | split_0_train_1471 | [
{
"id": "split_0_train_1471_passage",
"type": "progene_text",
"text": [
"Gel shift and supershift experiments using monoclonal antibodies toward Ku antigen and its individual subunits , and utilizing DP2 and other mutant oligonucleotides with purified nuclear protein extracts from control and cytokine - treated A549 cells , confirmed our findings ."
],
"offsets": [
[
0,
277
]
]
}
]
| [
{
"id": "split_0_train_2207_entity",
"type": "progene_text",
"text": [
"Ku antigen"
],
"offsets": [
[
72,
82
]
],
"normalized": []
},
{
"id": "split_0_train_2208_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
221,
229
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1472 | split_0_train_1472 | [
{
"id": "split_0_train_1472_passage",
"type": "progene_text",
"text": [
"Furthermore , electroporation of neutralizing anti - Ku70 , Ku 80 and Ku70 / 80 antibodies into A549 cells totally suppressed IL-13 and IL-4 - stimulated 15-LO-1 induction in these cells ."
],
"offsets": [
[
0,
188
]
]
}
]
| [
{
"id": "split_0_train_2209_entity",
"type": "progene_text",
"text": [
"Ku70"
],
"offsets": [
[
53,
57
]
],
"normalized": []
},
{
"id": "split_0_train_2210_entity",
"type": "progene_text",
"text": [
"Ku 80"
],
"offsets": [
[
60,
65
]
],
"normalized": []
},
{
"id": "split_0_train_2211_entity",
"type": "progene_text",
"text": [
"Ku70 / 80"
],
"offsets": [
[
70,
79
]
],
"normalized": []
},
{
"id": "split_0_train_2212_entity",
"type": "progene_text",
"text": [
"IL-13"
],
"offsets": [
[
126,
131
]
],
"normalized": []
},
{
"id": "split_0_train_2213_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
136,
140
]
],
"normalized": []
},
{
"id": "split_0_train_2214_entity",
"type": "progene_text",
"text": [
"15-LO-1"
],
"offsets": [
[
154,
161
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1473 | split_0_train_1473 | [
{
"id": "split_0_train_1473_passage",
"type": "progene_text",
"text": [
"Further , immunoprecipitation experiments data suggests that IL-4 and IL-13 activate Ku antigens and 15-LO-1 expression through distinct signaling events ."
],
"offsets": [
[
0,
155
]
]
}
]
| [
{
"id": "split_0_train_2215_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
61,
65
]
],
"normalized": []
},
{
"id": "split_0_train_2216_entity",
"type": "progene_text",
"text": [
"IL-13"
],
"offsets": [
[
70,
75
]
],
"normalized": []
},
{
"id": "split_0_train_2217_entity",
"type": "progene_text",
"text": [
"Ku antigens"
],
"offsets": [
[
85,
96
]
],
"normalized": []
},
{
"id": "split_0_train_2218_entity",
"type": "progene_text",
"text": [
"15-LO-1"
],
"offsets": [
[
101,
108
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1474 | split_0_train_1474 | [
{
"id": "split_0_train_1474_passage",
"type": "progene_text",
"text": [
"In summary , in A549 cells , Ku antigen is induced in response to the cytokines , IL-13 and - 4 , and a 29 bp region within the - 353 to - 304 bp region of the 15-LO-1 promoter is required for its binding and subsequent induction of 15-LO-1 gene expression ."
],
"offsets": [
[
0,
258
]
]
}
]
| [
{
"id": "split_0_train_2219_entity",
"type": "progene_text",
"text": [
"Ku antigen"
],
"offsets": [
[
29,
39
]
],
"normalized": []
},
{
"id": "split_0_train_2220_entity",
"type": "progene_text",
"text": [
"IL-13 and - 4"
],
"offsets": [
[
82,
95
]
],
"normalized": []
},
{
"id": "split_0_train_2221_entity",
"type": "progene_text",
"text": [
"15-LO-1"
],
"offsets": [
[
160,
167
]
],
"normalized": []
},
{
"id": "split_0_train_2222_entity",
"type": "progene_text",
"text": [
"15-LO-1"
],
"offsets": [
[
233,
240
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1475 | split_0_train_1475 | [
{
"id": "split_0_train_1475_passage",
"type": "progene_text",
"text": [
"The findings may provide an important link between the established dysregulated function of Ku antigen in auto - immune diseases , such as systemic lupus erythematosus and thyroiditis , and the increasingly recognized ' anti - inflammatory ' role of 15-LO-1 ."
],
"offsets": [
[
0,
259
]
]
}
]
| [
{
"id": "split_0_train_2223_entity",
"type": "progene_text",
"text": [
"Ku antigen"
],
"offsets": [
[
92,
102
]
],
"normalized": []
},
{
"id": "split_0_train_2224_entity",
"type": "progene_text",
"text": [
"15-LO-1"
],
"offsets": [
[
250,
257
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1476 | split_0_train_1476 | [
{
"id": "split_0_train_1476_passage",
"type": "progene_text",
"text": [
"Growth hormone receptor interaction with Jak proteins differs between tissues ."
],
"offsets": [
[
0,
79
]
]
}
]
| [
{
"id": "split_0_train_2225_entity",
"type": "progene_text",
"text": [
"Growth hormone receptor"
],
"offsets": [
[
0,
23
]
],
"normalized": []
},
{
"id": "split_0_train_2226_entity",
"type": "progene_text",
"text": [
"Jak"
],
"offsets": [
[
41,
44
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1477 | split_0_train_1477 | [
{
"id": "split_0_train_1477_passage",
"type": "progene_text",
"text": [
"Janus kinases ( Jak ) play an important role in the initial steps of cytokine receptor signaling ."
],
"offsets": [
[
0,
98
]
]
}
]
| [
{
"id": "split_0_train_2227_entity",
"type": "progene_text",
"text": [
"Janus kinases"
],
"offsets": [
[
0,
13
]
],
"normalized": []
},
{
"id": "split_0_train_2228_entity",
"type": "progene_text",
"text": [
"Jak"
],
"offsets": [
[
16,
19
]
],
"normalized": []
},
{
"id": "split_0_train_2229_entity",
"type": "progene_text",
"text": [
"cytokine receptor"
],
"offsets": [
[
69,
86
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1478 | split_0_train_1478 | [
{
"id": "split_0_train_1478_passage",
"type": "progene_text",
"text": [
"The specificity of the four members of the Jak family ( Jak1 , Jak2 , Jak3 , and Tyk2 ) for different cytokine receptors is not fully understood ."
],
"offsets": [
[
0,
146
]
]
}
]
| [
{
"id": "split_0_train_2230_entity",
"type": "progene_text",
"text": [
"Jak family"
],
"offsets": [
[
43,
53
]
],
"normalized": []
},
{
"id": "split_0_train_2231_entity",
"type": "progene_text",
"text": [
"Jak1"
],
"offsets": [
[
56,
60
]
],
"normalized": []
},
{
"id": "split_0_train_2232_entity",
"type": "progene_text",
"text": [
"Jak2"
],
"offsets": [
[
63,
67
]
],
"normalized": []
},
{
"id": "split_0_train_2233_entity",
"type": "progene_text",
"text": [
"Jak3"
],
"offsets": [
[
70,
74
]
],
"normalized": []
},
{
"id": "split_0_train_2234_entity",
"type": "progene_text",
"text": [
"Tyk2"
],
"offsets": [
[
81,
85
]
],
"normalized": []
},
{
"id": "split_0_train_2235_entity",
"type": "progene_text",
"text": [
"cytokine receptors"
],
"offsets": [
[
102,
120
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1479 | split_0_train_1479 | [
{
"id": "split_0_train_1479_passage",
"type": "progene_text",
"text": [
"Recent studies have indicated that a specific cytokine receptor can activate several Jak and that this may differ between tissues ."
],
"offsets": [
[
0,
131
]
]
}
]
| [
{
"id": "split_0_train_2236_entity",
"type": "progene_text",
"text": [
"cytokine receptor"
],
"offsets": [
[
46,
63
]
],
"normalized": []
},
{
"id": "split_0_train_2237_entity",
"type": "progene_text",
"text": [
"Jak"
],
"offsets": [
[
85,
88
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1480 | split_0_train_1480 | [
{
"id": "split_0_train_1480_passage",
"type": "progene_text",
"text": [
"The growth hormone receptor ( GHR ) is believed to interact predominantly with Jak2 , but studies on cell lines have shown that it may also induce phosphorylation of Jak1 and Jak3 ."
],
"offsets": [
[
0,
181
]
]
}
]
| [
{
"id": "split_0_train_2238_entity",
"type": "progene_text",
"text": [
"growth hormone receptor"
],
"offsets": [
[
4,
27
]
],
"normalized": []
},
{
"id": "split_0_train_2239_entity",
"type": "progene_text",
"text": [
"GHR"
],
"offsets": [
[
30,
33
]
],
"normalized": []
},
{
"id": "split_0_train_2240_entity",
"type": "progene_text",
"text": [
"Jak2"
],
"offsets": [
[
79,
83
]
],
"normalized": []
},
{
"id": "split_0_train_2241_entity",
"type": "progene_text",
"text": [
"Jak1"
],
"offsets": [
[
166,
170
]
],
"normalized": []
},
{
"id": "split_0_train_2242_entity",
"type": "progene_text",
"text": [
"Jak3"
],
"offsets": [
[
175,
179
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1481 | split_0_train_1481 | [
{
"id": "split_0_train_1481_passage",
"type": "progene_text",
"text": [
"Little is known about the interaction between the GHR and Jak in tissues ."
],
"offsets": [
[
0,
74
]
]
}
]
| [
{
"id": "split_0_train_2243_entity",
"type": "progene_text",
"text": [
"GHR"
],
"offsets": [
[
50,
53
]
],
"normalized": []
},
{
"id": "split_0_train_2244_entity",
"type": "progene_text",
"text": [
"Jak"
],
"offsets": [
[
58,
61
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1482 | split_0_train_1482 | [
{
"id": "split_0_train_1482_passage",
"type": "progene_text",
"text": [
"Our aim , therefore , was to elucidate which Jak interact with the GHR in two target tissues for GH , liver and adipose tissue ."
],
"offsets": [
[
0,
128
]
]
}
]
| [
{
"id": "split_0_train_2245_entity",
"type": "progene_text",
"text": [
"Jak"
],
"offsets": [
[
45,
48
]
],
"normalized": []
},
{
"id": "split_0_train_2246_entity",
"type": "progene_text",
"text": [
"GHR"
],
"offsets": [
[
67,
70
]
],
"normalized": []
},
{
"id": "split_0_train_2247_entity",
"type": "progene_text",
"text": [
"GH"
],
"offsets": [
[
97,
99
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1483 | split_0_train_1483 | [
{
"id": "split_0_train_1483_passage",
"type": "progene_text",
"text": [
"Western blot analysis showed that all four members of the Jak family are present in both rat liver and adipose tissue ."
],
"offsets": [
[
0,
119
]
]
}
]
| [
{
"id": "split_0_train_2248_entity",
"type": "progene_text",
"text": [
"Jak family"
],
"offsets": [
[
58,
68
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1484 | split_0_train_1484 | [
{
"id": "split_0_train_1484_passage",
"type": "progene_text",
"text": [
"However , coprecipitation using an anti - GHR antibody revealed that only Jak1 and Jak2 were associated with the GHR in these tissues ."
],
"offsets": [
[
0,
135
]
]
}
]
| [
{
"id": "split_0_train_2249_entity",
"type": "progene_text",
"text": [
"GHR"
],
"offsets": [
[
42,
45
]
],
"normalized": []
},
{
"id": "split_0_train_2250_entity",
"type": "progene_text",
"text": [
"Jak1"
],
"offsets": [
[
74,
78
]
],
"normalized": []
},
{
"id": "split_0_train_2251_entity",
"type": "progene_text",
"text": [
"Jak2"
],
"offsets": [
[
83,
87
]
],
"normalized": []
},
{
"id": "split_0_train_2252_entity",
"type": "progene_text",
"text": [
"GHR"
],
"offsets": [
[
113,
116
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1485 | split_0_train_1485 | [
{
"id": "split_0_train_1485_passage",
"type": "progene_text",
"text": [
"The relative amount of Jak1 and Jak2 that coprecipitated with the GHR differed markedly between tissues ."
],
"offsets": [
[
0,
105
]
]
}
]
| [
{
"id": "split_0_train_2253_entity",
"type": "progene_text",
"text": [
"Jak1"
],
"offsets": [
[
23,
27
]
],
"normalized": []
},
{
"id": "split_0_train_2254_entity",
"type": "progene_text",
"text": [
"Jak2"
],
"offsets": [
[
32,
36
]
],
"normalized": []
},
{
"id": "split_0_train_2255_entity",
"type": "progene_text",
"text": [
"GHR"
],
"offsets": [
[
66,
69
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1486 | split_0_train_1486 | [
{
"id": "split_0_train_1486_passage",
"type": "progene_text",
"text": [
"In the liver , Jak2 dominated , and only a small amount of Jak1 was detected ."
],
"offsets": [
[
0,
78
]
]
}
]
| [
{
"id": "split_0_train_2256_entity",
"type": "progene_text",
"text": [
"Jak2"
],
"offsets": [
[
15,
19
]
],
"normalized": []
},
{
"id": "split_0_train_2257_entity",
"type": "progene_text",
"text": [
"Jak1"
],
"offsets": [
[
59,
63
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1487 | split_0_train_1487 | [
{
"id": "split_0_train_1487_passage",
"type": "progene_text",
"text": [
"In adipose tissue , at least one third of the coprecipitated Jak was Jak1 ."
],
"offsets": [
[
0,
75
]
]
}
]
| [
{
"id": "split_0_train_2258_entity",
"type": "progene_text",
"text": [
"Jak"
],
"offsets": [
[
61,
64
]
],
"normalized": []
},
{
"id": "split_0_train_2259_entity",
"type": "progene_text",
"text": [
"Jak1"
],
"offsets": [
[
69,
73
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1488 | split_0_train_1488 | [
{
"id": "split_0_train_1488_passage",
"type": "progene_text",
"text": [
"This is the first study to show that both Jak1 and Jak2 are associated with the GHR in rat tissues ."
],
"offsets": [
[
0,
100
]
]
}
]
| [
{
"id": "split_0_train_2260_entity",
"type": "progene_text",
"text": [
"Jak1"
],
"offsets": [
[
42,
46
]
],
"normalized": []
},
{
"id": "split_0_train_2261_entity",
"type": "progene_text",
"text": [
"Jak2"
],
"offsets": [
[
51,
55
]
],
"normalized": []
},
{
"id": "split_0_train_2262_entity",
"type": "progene_text",
"text": [
"GHR"
],
"offsets": [
[
80,
83
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1489 | split_0_train_1489 | [
{
"id": "split_0_train_1489_passage",
"type": "progene_text",
"text": [
"The difference in the ratio between GHR - associated Jak1 and Jak2 in liver and adipose tissue may indicate that GHR signaling in different tissues could differ in terms of Jak specificity ."
],
"offsets": [
[
0,
190
]
]
}
]
| [
{
"id": "split_0_train_2263_entity",
"type": "progene_text",
"text": [
"GHR"
],
"offsets": [
[
36,
39
]
],
"normalized": []
},
{
"id": "split_0_train_2264_entity",
"type": "progene_text",
"text": [
"Jak1"
],
"offsets": [
[
53,
57
]
],
"normalized": []
},
{
"id": "split_0_train_2265_entity",
"type": "progene_text",
"text": [
"Jak2"
],
"offsets": [
[
62,
66
]
],
"normalized": []
},
{
"id": "split_0_train_2266_entity",
"type": "progene_text",
"text": [
"GHR"
],
"offsets": [
[
113,
116
]
],
"normalized": []
},
{
"id": "split_0_train_2267_entity",
"type": "progene_text",
"text": [
"Jak"
],
"offsets": [
[
173,
176
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1490 | split_0_train_1490 | [
{
"id": "split_0_train_1490_passage",
"type": "progene_text",
"text": [
"Mitochondrial translation of Saccharomyces cerevisiae COX2 mRNA is controlled by the nucleotide sequence specifying the pre - Cox2p leader peptide ."
],
"offsets": [
[
0,
148
]
]
}
]
| [
{
"id": "split_0_train_2268_entity",
"type": "progene_text",
"text": [
"COX2"
],
"offsets": [
[
54,
58
]
],
"normalized": []
},
{
"id": "split_0_train_2269_entity",
"type": "progene_text",
"text": [
"Cox2p"
],
"offsets": [
[
126,
131
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1491 | split_0_train_1491 | [
{
"id": "split_0_train_1491_passage",
"type": "progene_text",
"text": [
"The mitochondrial gene encoding yeast cytochrome oxidase subunit II ( Cox2p ) specifies a precursor protein with a 15 - amino - acid leader peptide ."
],
"offsets": [
[
0,
149
]
]
}
]
| [
{
"id": "split_0_train_2270_entity",
"type": "progene_text",
"text": [
"cytochrome oxidase subunit II"
],
"offsets": [
[
38,
67
]
],
"normalized": []
},
{
"id": "split_0_train_2271_entity",
"type": "progene_text",
"text": [
"Cox2p"
],
"offsets": [
[
70,
75
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1492 | split_0_train_1492 | [
{
"id": "split_0_train_1492_passage",
"type": "progene_text",
"text": [
"Deletion of the entire leader peptide coding region is known to block Cox2p accumulation posttranscriptionally ."
],
"offsets": [
[
0,
112
]
]
}
]
| [
{
"id": "split_0_train_2272_entity",
"type": "progene_text",
"text": [
"Cox2p"
],
"offsets": [
[
70,
75
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1493 | split_0_train_1493 | [
{
"id": "split_0_train_1493_passage",
"type": "progene_text",
"text": [
"Here , we examined in vivo the role of the pre - Cox2p leader peptide and the mRNA sequence that encodes it in the expression of a mitochondrial reporter gene , ARG8m , fused to the 91st codon of COX2 ."
],
"offsets": [
[
0,
202
]
]
}
]
| [
{
"id": "split_0_train_2273_entity",
"type": "progene_text",
"text": [
"Cox2p"
],
"offsets": [
[
49,
54
]
],
"normalized": []
},
{
"id": "split_0_train_2274_entity",
"type": "progene_text",
"text": [
"ARG8m"
],
"offsets": [
[
161,
166
]
],
"normalized": []
},
{
"id": "split_0_train_2275_entity",
"type": "progene_text",
"text": [
"COX2"
],
"offsets": [
[
196,
200
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1494 | split_0_train_1494 | [
{
"id": "split_0_train_1494_passage",
"type": "progene_text",
"text": [
"We found within the coding sequence antagonistic elements that control translation : the positive element includes sequences in the first 14 codons specifying the leader peptide , while the negative element appears to be within codons 15 to 91 ."
],
"offsets": [
[
0,
245
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1495 | split_0_train_1495 | [
{
"id": "split_0_train_1495_passage",
"type": "progene_text",
"text": [
"Partial deletions , point mutations , and local frameshifts within the leader peptide coding region were placed in both the cox2 : : ARG8m reporter and in COX2 itself ."
],
"offsets": [
[
0,
168
]
]
}
]
| [
{
"id": "split_0_train_2276_entity",
"type": "progene_text",
"text": [
"cox2"
],
"offsets": [
[
124,
128
]
],
"normalized": []
},
{
"id": "split_0_train_2277_entity",
"type": "progene_text",
"text": [
"ARG8m"
],
"offsets": [
[
133,
138
]
],
"normalized": []
},
{
"id": "split_0_train_2278_entity",
"type": "progene_text",
"text": [
"COX2"
],
"offsets": [
[
155,
159
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1496 | split_0_train_1496 | [
{
"id": "split_0_train_1496_passage",
"type": "progene_text",
"text": [
"Surprisingly , the mRNA sequence of the first six codons specifying the leader peptide plays an important role in positively controlling translation , while the amino acid sequence of the leader peptide itself is relatively unconstrained ."
],
"offsets": [
[
0,
239
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1497 | split_0_train_1497 | [
{
"id": "split_0_train_1497_passage",
"type": "progene_text",
"text": [
"Two mutations that partially block translation can be suppressed by nearby sequence substitutions that weaken a predicted stem structure and by overproduction of either the COX2 mRNA - specific translational activator Pet111p or the large - subunit mitochondrial ribosomal protein MrpL36p ."
],
"offsets": [
[
0,
290
]
]
}
]
| [
{
"id": "split_0_train_2279_entity",
"type": "progene_text",
"text": [
"COX2"
],
"offsets": [
[
173,
177
]
],
"normalized": []
},
{
"id": "split_0_train_2280_entity",
"type": "progene_text",
"text": [
"Pet111p"
],
"offsets": [
[
218,
225
]
],
"normalized": []
},
{
"id": "split_0_train_2281_entity",
"type": "progene_text",
"text": [
"MrpL36p"
],
"offsets": [
[
281,
288
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1498 | split_0_train_1498 | [
{
"id": "split_0_train_1498_passage",
"type": "progene_text",
"text": [
"We propose that regulatory elements embedded in the translated COX2 mRNA sequence could play a role , together with trans - acting factors , in coupling regulated synthesis of nascent pre - Cox2p to its insertion in the mitochondrial inner membrane ."
],
"offsets": [
[
0,
250
]
]
}
]
| [
{
"id": "split_0_train_2282_entity",
"type": "progene_text",
"text": [
"COX2"
],
"offsets": [
[
63,
67
]
],
"normalized": []
},
{
"id": "split_0_train_2283_entity",
"type": "progene_text",
"text": [
"Cox2p"
],
"offsets": [
[
190,
195
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1499 | split_0_train_1499 | [
{
"id": "split_0_train_1499_passage",
"type": "progene_text",
"text": [
"Involvement of a triton - insoluble floating fraction in Dictyostelium cell - cell adhesion ."
],
"offsets": [
[
0,
93
]
]
}
]
| []
| []
| []
| []
|
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