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stringlengths 15
19
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list | entities
list | events
list | coreferences
list | relations
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split_0_train_1500 | split_0_train_1500 | [
{
"id": "split_0_train_1500_passage",
"type": "progene_text",
"text": [
"We have isolated and characterized a Triton - insoluble floating fraction ( TIFF ) from Dictyostelium ."
],
"offsets": [
[
0,
103
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1501 | split_0_train_1501 | [
{
"id": "split_0_train_1501_passage",
"type": "progene_text",
"text": [
"Ten major proteins were consistently detected in TIFF , and six species were identified by mass spectrometry as actin , porin , comitin , regulatory myosin light chain , a novel member of the CD36 family , and the phospholipid - anchored cell adhesion molecule gp80 ."
],
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0,
267
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{
"id": "split_0_train_2284_entity",
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"text": [
"actin"
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112,
117
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{
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120,
125
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{
"id": "split_0_train_2286_entity",
"type": "progene_text",
"text": [
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128,
135
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{
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"text": [
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149,
167
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{
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"text": [
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192,
203
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{
"id": "split_0_train_2289_entity",
"type": "progene_text",
"text": [
"gp80"
],
"offsets": [
[
261,
265
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1502 | split_0_train_1502 | [
{
"id": "split_0_train_1502_passage",
"type": "progene_text",
"text": [
"TIFF was enriched with many acylated proteins ."
],
"offsets": [
[
0,
47
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1503 | split_0_train_1503 | [
{
"id": "split_0_train_1503_passage",
"type": "progene_text",
"text": [
"Also , the sterol / phospholipid ratio of TIFF was 10 - fold higher than that of the bulk plasma membrane ."
],
"offsets": [
[
0,
107
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1504 | split_0_train_1504 | [
{
"id": "split_0_train_1504_passage",
"type": "progene_text",
"text": [
"Immunoelectron microscopy showed that TIFF has vesicular morphology and confirmed the association of gp80 and comitin with TIFF membranes ."
],
"offsets": [
[
0,
139
]
]
}
]
| [
{
"id": "split_0_train_2290_entity",
"type": "progene_text",
"text": [
"gp80"
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[
101,
105
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{
"id": "split_0_train_2291_entity",
"type": "progene_text",
"text": [
"comitin"
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[
110,
117
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1505 | split_0_train_1505 | [
{
"id": "split_0_train_1505_passage",
"type": "progene_text",
"text": [
"Several TIFF properties were similar to those of Dictyostelium contact regions , which were isolated as a cytoskeleton - associated membrane fraction ."
],
"offsets": [
[
0,
151
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1506 | split_0_train_1506 | [
{
"id": "split_0_train_1506_passage",
"type": "progene_text",
"text": [
"Mass spectrometry demonstrated that TIFF and contact regions shared the same major proteins ."
],
"offsets": [
[
0,
93
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1507 | split_0_train_1507 | [
{
"id": "split_0_train_1507_passage",
"type": "progene_text",
"text": [
"During development , gp80 colocalized with F-actin , porin , and comitin at cell - cell contacts ."
],
"offsets": [
[
0,
98
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]
}
]
| [
{
"id": "split_0_train_2292_entity",
"type": "progene_text",
"text": [
"gp80"
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[
21,
25
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{
"id": "split_0_train_2293_entity",
"type": "progene_text",
"text": [
"F-actin"
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43,
50
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{
"id": "split_0_train_2294_entity",
"type": "progene_text",
"text": [
"porin"
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[
53,
58
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{
"id": "split_0_train_2295_entity",
"type": "progene_text",
"text": [
"comitin"
],
"offsets": [
[
65,
72
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1508 | split_0_train_1508 | [
{
"id": "split_0_train_1508_passage",
"type": "progene_text",
"text": [
"These proteins were also recruited to gp80 caps induced by antibody cross - linking ."
],
"offsets": [
[
0,
85
]
]
}
]
| [
{
"id": "split_0_train_2296_entity",
"type": "progene_text",
"text": [
"gp80"
],
"offsets": [
[
38,
42
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1509 | split_0_train_1509 | [
{
"id": "split_0_train_1509_passage",
"type": "progene_text",
"text": [
"Filipin staining revealed high sterol levels in both gp80 - enriched cell - cell contacts and gp80 caps ."
],
"offsets": [
[
0,
105
]
]
}
]
| [
{
"id": "split_0_train_2297_entity",
"type": "progene_text",
"text": [
"gp80"
],
"offsets": [
[
53,
57
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"normalized": []
},
{
"id": "split_0_train_2298_entity",
"type": "progene_text",
"text": [
"gp80"
],
"offsets": [
[
94,
98
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1510 | split_0_train_1510 | [
{
"id": "split_0_train_1510_passage",
"type": "progene_text",
"text": [
"Moreover , sterol sequestration by filipin and digitonin inhibited gp80 - mediated cell - cell adhesion ."
],
"offsets": [
[
0,
105
]
]
}
]
| [
{
"id": "split_0_train_2299_entity",
"type": "progene_text",
"text": [
"gp80"
],
"offsets": [
[
67,
71
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1511 | split_0_train_1511 | [
{
"id": "split_0_train_1511_passage",
"type": "progene_text",
"text": [
"This study reveals that Dictyostelium TIFF has structural properties previously attributed to vertebrate TIFF and establishes a role for Dictyostelium TIFF in cell - cell adhesion during development ."
],
"offsets": [
[
0,
200
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1512 | split_0_train_1512 | [
{
"id": "split_0_train_1512_passage",
"type": "progene_text",
"text": [
"Involvement of Rel / NF-kappaB in regulation of ascidian notochord formation ."
],
"offsets": [
[
0,
78
]
]
}
]
| [
{
"id": "split_0_train_2300_entity",
"type": "progene_text",
"text": [
"Rel"
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"offsets": [
[
15,
18
]
],
"normalized": []
},
{
"id": "split_0_train_2301_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
21,
30
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1513 | split_0_train_1513 | [
{
"id": "split_0_train_1513_passage",
"type": "progene_text",
"text": [
"The Rel / NF-kappaB family is known to be involved in a wide variety of biological processes , including morphogenesis ."
],
"offsets": [
[
0,
120
]
]
}
]
| [
{
"id": "split_0_train_2302_entity",
"type": "progene_text",
"text": [
"Rel / NF-kappaB family"
],
"offsets": [
[
4,
26
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1514 | split_0_train_1514 | [
{
"id": "split_0_train_1514_passage",
"type": "progene_text",
"text": [
"In the present study , two protochordate cDNA clones encoding Rel / NF-kappaB proteins , named As - rel1 and As - rel2 , were isolated from a fertilized egg cDNA library of the ascidian Halocynthia roretzi ."
],
"offsets": [
[
0,
207
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]
}
]
| [
{
"id": "split_0_train_2303_entity",
"type": "progene_text",
"text": [
"Rel"
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"offsets": [
[
62,
65
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{
"id": "split_0_train_2304_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
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"offsets": [
[
68,
77
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{
"id": "split_0_train_2305_entity",
"type": "progene_text",
"text": [
"rel1"
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[
100,
104
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},
{
"id": "split_0_train_2306_entity",
"type": "progene_text",
"text": [
"rel2"
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"offsets": [
[
114,
118
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1515 | split_0_train_1515 | [
{
"id": "split_0_train_1515_passage",
"type": "progene_text",
"text": [
"The As - rel1 protein is a typical Rel / NF-kappaB family member , containing a Rel homology domain , a nuclear localization sequence and a C - terminal putative transcription activation domain , while the As - rel2 protein is a novel Rel / NF-kappaB family member that lacks a nuclear localization sequence and the C - terminal domain ."
],
"offsets": [
[
0,
337
]
]
}
]
| [
{
"id": "split_0_train_2307_entity",
"type": "progene_text",
"text": [
"rel1"
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"offsets": [
[
9,
13
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},
{
"id": "split_0_train_2308_entity",
"type": "progene_text",
"text": [
"Rel / NF-kappaB family"
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"offsets": [
[
35,
57
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},
{
"id": "split_0_train_2309_entity",
"type": "progene_text",
"text": [
"Rel"
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"offsets": [
[
80,
83
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{
"id": "split_0_train_2310_entity",
"type": "progene_text",
"text": [
"rel2"
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211,
215
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{
"id": "split_0_train_2311_entity",
"type": "progene_text",
"text": [
"Rel / NF-kappaB family"
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"offsets": [
[
235,
257
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1516 | split_0_train_1516 | [
{
"id": "split_0_train_1516_passage",
"type": "progene_text",
"text": [
"Northern blot analyses showed that both transcripts were maternally expressed and that their expression changed during development of H. roretzi embryos ."
],
"offsets": [
[
0,
154
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1517 | split_0_train_1517 | [
{
"id": "split_0_train_1517_passage",
"type": "progene_text",
"text": [
"Although injection of the As - rel2 mRNA into H. roretzi fertilized eggs had little effect on embryonic development , injection of the As - rel1 mRNA interfered greatly with notochord formation , resulting in a shortened tail with a reduced number of notochord cells ."
],
"offsets": [
[
0,
268
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]
}
]
| [
{
"id": "split_0_train_2312_entity",
"type": "progene_text",
"text": [
"rel2"
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31,
35
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{
"id": "split_0_train_2313_entity",
"type": "progene_text",
"text": [
"rel1"
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"offsets": [
[
140,
144
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1518 | split_0_train_1518 | [
{
"id": "split_0_train_1518_passage",
"type": "progene_text",
"text": [
"In contrast , embryos co - injected with As - rel1 and As - rel2 mRNA developed normally , indicating that the As - rel2 protein rescued the defect in notochord formation induced by the injection of As - rel1 mRNA alone ."
],
"offsets": [
[
0,
221
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]
}
]
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{
"id": "split_0_train_2314_entity",
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46,
50
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{
"id": "split_0_train_2315_entity",
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60,
64
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{
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116,
120
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{
"id": "split_0_train_2317_entity",
"type": "progene_text",
"text": [
"rel1"
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"offsets": [
[
204,
208
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}
]
| []
| []
| []
|
split_0_train_1519 | split_0_train_1519 | [
{
"id": "split_0_train_1519_passage",
"type": "progene_text",
"text": [
"These results strongly suggest that the As - rel1 protein functions as a suppressor in ascidian notochord formation , while the As - rel2 protein has an antagonistic effect on the action of the As - rel1 protein ."
],
"offsets": [
[
0,
213
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]
}
]
| [
{
"id": "split_0_train_2318_entity",
"type": "progene_text",
"text": [
"rel1"
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"offsets": [
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45,
49
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{
"id": "split_0_train_2319_entity",
"type": "progene_text",
"text": [
"rel2"
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133,
137
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{
"id": "split_0_train_2320_entity",
"type": "progene_text",
"text": [
"rel1"
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"offsets": [
[
199,
203
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1520 | split_0_train_1520 | [
{
"id": "split_0_train_1520_passage",
"type": "progene_text",
"text": [
"IL-10 mediation of activation - induced TH1 cell apoptosis and lymphoid dysfunction in polymicrobial sepsis ."
],
"offsets": [
[
0,
109
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]
}
]
| [
{
"id": "split_0_train_2321_entity",
"type": "progene_text",
"text": [
"IL-10"
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"offsets": [
[
0,
5
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}
]
| []
| []
| []
|
split_0_train_1521 | split_0_train_1521 | [
{
"id": "split_0_train_1521_passage",
"type": "progene_text",
"text": [
"Recent studies suggest that increased activation - induced lymphocyte apoptosis ( AICD ) is detected in mouse splenocytes during polymicrobial sepsis which may contribute to lymphocyte immune dysfunction [ i.e. , decreased interleukin ( IL-) 2 and interferon-gamma ( IFN-gamma ) production ] leading to the associated morbidity seen in those animals ."
],
"offsets": [
[
0,
351
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]
}
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| [
{
"id": "split_0_train_2322_entity",
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"text": [
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223,
243
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{
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248,
264
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{
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"type": "progene_text",
"text": [
"IFN-gamma"
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267,
276
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}
]
| []
| []
| []
|
split_0_train_1522 | split_0_train_1522 | [
{
"id": "split_0_train_1522_passage",
"type": "progene_text",
"text": [
"Thus , we wanted to examine the hypothesis that immune suppressive agents , such as IL-4 , IL-10 or prostaglandin E2 ( PGE2 ) , known to be elevated in septic animals , also contribute to this increase in AICD ."
],
"offsets": [
[
0,
211
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}
]
| [
{
"id": "split_0_train_2325_entity",
"type": "progene_text",
"text": [
"IL-4"
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84,
88
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{
"id": "split_0_train_2326_entity",
"type": "progene_text",
"text": [
"IL-10"
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"offsets": [
[
91,
96
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1523 | split_0_train_1523 | [
{
"id": "split_0_train_1523_passage",
"type": "progene_text",
"text": [
"Here we demonstrate that the inclusion of monoclonal antibody ( mAb ) to IL-10 , but not anti - IL-4 or ibuprofen ( IBU ) , blunted this sepsis induced increase in splenocyte AICD ."
],
"offsets": [
[
0,
181
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]
}
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| [
{
"id": "split_0_train_2327_entity",
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"IL-10"
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73,
78
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{
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"IL-4"
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96,
100
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]
| []
| []
| []
|
split_0_train_1524 | split_0_train_1524 | [
{
"id": "split_0_train_1524_passage",
"type": "progene_text",
"text": [
"Additionally , septic mice deficient in the IL-10 gene product ( -/- ) showed neither an increase in AICD nor a loss of IL-2 / IFN-gamma release capacity ."
],
"offsets": [
[
0,
155
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]
}
]
| [
{
"id": "split_0_train_2329_entity",
"type": "progene_text",
"text": [
"IL-10"
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44,
49
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{
"id": "split_0_train_2330_entity",
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120,
124
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{
"id": "split_0_train_2331_entity",
"type": "progene_text",
"text": [
"IFN-gamma"
],
"offsets": [
[
127,
136
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1525 | split_0_train_1525 | [
{
"id": "split_0_train_1525_passage",
"type": "progene_text",
"text": [
"Interestingly , mAb to IL-10 did not altered the extent of AICD in a Th2 - cell line , but exogenous IL-10 did potentiate Th1 - like cell line AICD ."
],
"offsets": [
[
0,
149
]
]
}
]
| [
{
"id": "split_0_train_2332_entity",
"type": "progene_text",
"text": [
"IL-10"
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23,
28
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{
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"type": "progene_text",
"text": [
"IL-10"
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"offsets": [
[
101,
106
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1526 | split_0_train_1526 | [
{
"id": "split_0_train_1526_passage",
"type": "progene_text",
"text": [
"This was consistent with the finding that the increased AICD seen in septic mouse splenocytes was restricted largely to the CD4 + cells producing IL-2 ( Th1 - cells ) and that mAb to IL-10 treatment suppressed this change ."
],
"offsets": [
[
0,
223
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| [
{
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"CD4"
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124,
127
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{
"id": "split_0_train_2335_entity",
"type": "progene_text",
"text": [
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146,
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{
"id": "split_0_train_2336_entity",
"type": "progene_text",
"text": [
"IL-10"
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[
183,
188
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1527 | split_0_train_1527 | [
{
"id": "split_0_train_1527_passage",
"type": "progene_text",
"text": [
"Furthermore , IL-10 appears to mediate its AICD effect by upregulation of the Fas receptor and Fas receptor signaling protein components , but not by altered expression of Bcl / Bax / Bad family members , in septic mouse splenocytes ."
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"offsets": [
[
0,
234
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}
]
| [
{
"id": "split_0_train_2337_entity",
"type": "progene_text",
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"IL-10"
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14,
19
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},
{
"id": "split_0_train_2338_entity",
"type": "progene_text",
"text": [
"Fas"
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[
78,
81
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},
{
"id": "split_0_train_2339_entity",
"type": "progene_text",
"text": [
"Fas"
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95,
98
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},
{
"id": "split_0_train_2340_entity",
"type": "progene_text",
"text": [
"Bcl / Bax / Bad family"
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"offsets": [
[
172,
194
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],
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}
]
| []
| []
| []
|
split_0_train_1528 | split_0_train_1528 | [
{
"id": "split_0_train_1528_passage",
"type": "progene_text",
"text": [
"To the extent that these processes contribute in a pathological fashion to the animal 's capacity to survive sepsis we have previously observed that in vivo post - treatment of mice with mAb IL-10 markedly attenuated septic mortality ."
],
"offsets": [
[
0,
235
]
]
}
]
| [
{
"id": "split_0_train_2341_entity",
"type": "progene_text",
"text": [
"IL-10"
],
"offsets": [
[
191,
196
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1529 | split_0_train_1529 | [
{
"id": "split_0_train_1529_passage",
"type": "progene_text",
"text": [
"Collectively , these data indicate that in the septic mouse the Th2 cytokine IL-10 not only serves to actively induce Th1 lymphocyte immune dysfunction but also plays a role in their apoptotic depletion ."
],
"offsets": [
[
0,
204
]
]
}
]
| [
{
"id": "split_0_train_2342_entity",
"type": "progene_text",
"text": [
"cytokine"
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[
68,
76
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},
{
"id": "split_0_train_2343_entity",
"type": "progene_text",
"text": [
"IL-10"
],
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[
77,
82
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1530 | split_0_train_1530 | [
{
"id": "split_0_train_1530_passage",
"type": "progene_text",
"text": [
"These processes in turn appear to contribute to the animal 's inability to ward off lethal septic challenge ."
],
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[
0,
109
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1531 | split_0_train_1531 | [
{
"id": "split_0_train_1531_passage",
"type": "progene_text",
"text": [
"Differential NF-kappa B regulation of bcl-x gene expression in hippocampus and basal forebrain in response to hypoxia ."
],
"offsets": [
[
0,
119
]
]
}
]
| [
{
"id": "split_0_train_2344_entity",
"type": "progene_text",
"text": [
"NF-kappa B"
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"offsets": [
[
13,
23
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"normalized": []
},
{
"id": "split_0_train_2345_entity",
"type": "progene_text",
"text": [
"bcl-x"
],
"offsets": [
[
38,
43
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1532 | split_0_train_1532 | [
{
"id": "split_0_train_1532_passage",
"type": "progene_text",
"text": [
"Cell death often occurs after hypoxic / ischemic injury to the central nervous system ."
],
"offsets": [
[
0,
87
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1533 | split_0_train_1533 | [
{
"id": "split_0_train_1533_passage",
"type": "progene_text",
"text": [
"Changes in levels of the anti - apoptotic Bcl-X(L) protein may be a determining factor in hypoxia - induced neuronal apoptosis ."
],
"offsets": [
[
0,
128
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]
}
]
| [
{
"id": "split_0_train_2346_entity",
"type": "progene_text",
"text": [
"Bcl-X(L)"
],
"offsets": [
[
42,
50
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1534 | split_0_train_1534 | [
{
"id": "split_0_train_1534_passage",
"type": "progene_text",
"text": [
"The transcription factor NF-kappa B regulates bcl-x gene expression ."
],
"offsets": [
[
0,
69
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]
}
]
| [
{
"id": "split_0_train_2347_entity",
"type": "progene_text",
"text": [
"transcription factor"
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4,
24
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{
"id": "split_0_train_2348_entity",
"type": "progene_text",
"text": [
"NF-kappa B"
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25,
35
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{
"id": "split_0_train_2349_entity",
"type": "progene_text",
"text": [
"bcl-x"
],
"offsets": [
[
46,
51
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1535 | split_0_train_1535 | [
{
"id": "split_0_train_1535_passage",
"type": "progene_text",
"text": [
"In this study , we examined the role of NF-kappa B in the regulation of bcl-x in hypoxia - induced cell death ."
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[
0,
111
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]
}
]
| [
{
"id": "split_0_train_2350_entity",
"type": "progene_text",
"text": [
"NF-kappa B"
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40,
50
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{
"id": "split_0_train_2351_entity",
"type": "progene_text",
"text": [
"bcl-x"
],
"offsets": [
[
72,
77
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1536 | split_0_train_1536 | [
{
"id": "split_0_train_1536_passage",
"type": "progene_text",
"text": [
"Rat hippocampus and basal forebrain tissues were collected at different time points after hypoxia ( 7 % O(2) , 93 % N(2) for 10 or 20 min ) ."
],
"offsets": [
[
0,
141
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1537 | split_0_train_1537 | [
{
"id": "split_0_train_1537_passage",
"type": "progene_text",
"text": [
"We found that 1) hypoxia induced apoptosis in the hippocampus and basal forebrain ; 2 ) the NF-kappa B dimers c-Rel / p50 and p50 / p50 bound to the bcl-x promoter NF-kappa B sequence ( CS4 ) in the hippocampus , but only p50 / p50 bound to the CS4 sequence in the basal forebrain and hypoxia - induced differential binding patterns of c-Rel / p50 and p50 / p50 correlated with the bcl-x expression pattern in the hippocampus ; 3) the hypoxia - induced patterns of binding of c-Rel / p50 to the bcl - x promoter CS4 sequence were different from those to the IgG-kappa B enhancer sequence , whereas those of p50 / p50 were similar to both sequences ; 4 ) nuclear protein levels of c-Rel , but not p50 , correlated with the c-Rel / p50 DNA binding patterns to the bcl - x CS4 site ; and 5 ) there were differential responses to hypoxia among the different NF-kappa B protein subunits ."
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0,
883
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}
]
| [
{
"id": "split_0_train_2352_entity",
"type": "progene_text",
"text": [
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92,
102
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{
"id": "split_0_train_2353_entity",
"type": "progene_text",
"text": [
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110,
115
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{
"id": "split_0_train_2354_entity",
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"p50"
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118,
121
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"id": "split_0_train_2355_entity",
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126,
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{
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"p50"
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132,
135
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{
"id": "split_0_train_2357_entity",
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"text": [
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149,
154
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{
"id": "split_0_train_2358_entity",
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"text": [
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164,
174
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{
"id": "split_0_train_2359_entity",
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222,
225
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{
"id": "split_0_train_2360_entity",
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228,
231
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{
"id": "split_0_train_2361_entity",
"type": "progene_text",
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336,
341
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{
"id": "split_0_train_2362_entity",
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344,
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352,
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358,
361
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"text": [
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382,
387
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{
"id": "split_0_train_2366_entity",
"type": "progene_text",
"text": [
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476,
481
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{
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"text": [
"p50"
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484,
487
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{
"id": "split_0_train_2368_entity",
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"text": [
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495,
502
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{
"id": "split_0_train_2369_entity",
"type": "progene_text",
"text": [
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558,
569
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{
"id": "split_0_train_2370_entity",
"type": "progene_text",
"text": [
"p50"
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607,
610
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{
"id": "split_0_train_2371_entity",
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613,
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{
"id": "split_0_train_2372_entity",
"type": "progene_text",
"text": [
"c-Rel"
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680,
685
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"normalized": []
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{
"id": "split_0_train_2373_entity",
"type": "progene_text",
"text": [
"p50"
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696,
699
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"normalized": []
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{
"id": "split_0_train_2374_entity",
"type": "progene_text",
"text": [
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722,
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},
{
"id": "split_0_train_2375_entity",
"type": "progene_text",
"text": [
"p50"
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"offsets": [
[
730,
733
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"normalized": []
},
{
"id": "split_0_train_2376_entity",
"type": "progene_text",
"text": [
"bcl - x"
],
"offsets": [
[
762,
769
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"normalized": []
},
{
"id": "split_0_train_2377_entity",
"type": "progene_text",
"text": [
"NF-kappa B"
],
"offsets": [
[
854,
864
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1538 | split_0_train_1538 | [
{
"id": "split_0_train_1538_passage",
"type": "progene_text",
"text": [
"These results suggest that there is a tissue - specific regulation of bcl-x gene expression by NF-kappa B in hypoxia - induced cell death in the hippocampus ."
],
"offsets": [
[
0,
158
]
]
}
]
| [
{
"id": "split_0_train_2378_entity",
"type": "progene_text",
"text": [
"bcl-x"
],
"offsets": [
[
70,
75
]
],
"normalized": []
},
{
"id": "split_0_train_2379_entity",
"type": "progene_text",
"text": [
"NF-kappa B"
],
"offsets": [
[
95,
105
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1539 | split_0_train_1539 | [
{
"id": "split_0_train_1539_passage",
"type": "progene_text",
"text": [
"The absence of these regulating features in the basal forebrain may account for the early appearance of apoptosis in response to hypoxia as compared with that in hippocampus ."
],
"offsets": [
[
0,
175
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1540 | split_0_train_1540 | [
{
"id": "split_0_train_1540_passage",
"type": "progene_text",
"text": [
"Extensive repertoire of membrane - bound and soluble dendritic cell - specific ICAM - 3 - grabbing nonintegrin 1 ( DC-SIGN1 ) and DC-SIGN2 isoforms ."
],
"offsets": [
[
0,
149
]
]
}
]
| [
{
"id": "split_0_train_2380_entity",
"type": "progene_text",
"text": [
"dendritic cell - specific ICAM - 3 - grabbing nonintegrin 1"
],
"offsets": [
[
53,
112
]
],
"normalized": []
},
{
"id": "split_0_train_2381_entity",
"type": "progene_text",
"text": [
"DC-SIGN1"
],
"offsets": [
[
115,
123
]
],
"normalized": []
},
{
"id": "split_0_train_2382_entity",
"type": "progene_text",
"text": [
"DC-SIGN2"
],
"offsets": [
[
130,
138
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1541 | split_0_train_1541 | [
{
"id": "split_0_train_1541_passage",
"type": "progene_text",
"text": [
"Inter - individual variation in expression of DC-SIGN transcripts ."
],
"offsets": [
[
0,
67
]
]
}
]
| [
{
"id": "split_0_train_2383_entity",
"type": "progene_text",
"text": [
"DC-SIGN"
],
"offsets": [
[
46,
53
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1542 | split_0_train_1542 | [
{
"id": "split_0_train_1542_passage",
"type": "progene_text",
"text": [
"Expression in dendritic cells ( DCs ) of DC-SIGN , a type II membrane protein with a C - type lectin ectodomain , is thought to play an important role in establishing the initial contact between DCs and resting T cells ."
],
"offsets": [
[
0,
220
]
]
}
]
| [
{
"id": "split_0_train_2384_entity",
"type": "progene_text",
"text": [
"DC-SIGN"
],
"offsets": [
[
41,
48
]
],
"normalized": []
},
{
"id": "split_0_train_2385_entity",
"type": "progene_text",
"text": [
"C - type lectin"
],
"offsets": [
[
85,
100
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1543 | split_0_train_1543 | [
{
"id": "split_0_train_1543_passage",
"type": "progene_text",
"text": [
"DC-SIGN is also a unique type of human immunodeficiency virus-1 ( HIV-1 ) attachment factor and promotes efficient infection in trans of cells that express CD4 and chemokine receptors ."
],
"offsets": [
[
0,
185
]
]
}
]
| [
{
"id": "split_0_train_2386_entity",
"type": "progene_text",
"text": [
"DC-SIGN"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "split_0_train_2387_entity",
"type": "progene_text",
"text": [
"CD4"
],
"offsets": [
[
156,
159
]
],
"normalized": []
},
{
"id": "split_0_train_2388_entity",
"type": "progene_text",
"text": [
"chemokine receptors"
],
"offsets": [
[
164,
183
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1544 | split_0_train_1544 | [
{
"id": "split_0_train_1544_passage",
"type": "progene_text",
"text": [
"We have identified another gene , designated here as DC-SIGN2 , that exhibits high sequence homology with DC-SIGN ."
],
"offsets": [
[
0,
115
]
]
}
]
| [
{
"id": "split_0_train_2389_entity",
"type": "progene_text",
"text": [
"DC-SIGN2"
],
"offsets": [
[
53,
61
]
],
"normalized": []
},
{
"id": "split_0_train_2390_entity",
"type": "progene_text",
"text": [
"DC-SIGN"
],
"offsets": [
[
106,
113
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1545 | split_0_train_1545 | [
{
"id": "split_0_train_1545_passage",
"type": "progene_text",
"text": [
"Here we demonstrate that alternative splicing of DC-SIGN1 ( original version ) and DC-SIGN2 pre - mRNA generates a large repertoire of DC-SIGN - like transcripts that are predicted to encode membrane - associated and soluble isoforms ."
],
"offsets": [
[
0,
235
]
]
}
]
| [
{
"id": "split_0_train_2391_entity",
"type": "progene_text",
"text": [
"DC-SIGN1"
],
"offsets": [
[
49,
57
]
],
"normalized": []
},
{
"id": "split_0_train_2392_entity",
"type": "progene_text",
"text": [
"DC-SIGN2"
],
"offsets": [
[
83,
91
]
],
"normalized": []
},
{
"id": "split_0_train_2393_entity",
"type": "progene_text",
"text": [
"DC-SIGN"
],
"offsets": [
[
135,
142
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1546 | split_0_train_1546 | [
{
"id": "split_0_train_1546_passage",
"type": "progene_text",
"text": [
"The range of DC-SIGN1 mRNA expression was significantly broader than previously reported and included THP-1 monocytic cells , placenta , and peripheral blood mononuclear cells ( PBMCs ) , and there was cell maturation / activation - induced differences in mRNA expression levels ."
],
"offsets": [
[
0,
280
]
]
}
]
| [
{
"id": "split_0_train_2394_entity",
"type": "progene_text",
"text": [
"DC-SIGN1"
],
"offsets": [
[
13,
21
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1547 | split_0_train_1547 | [
{
"id": "split_0_train_1547_passage",
"type": "progene_text",
"text": [
"Immunostaining of term placenta with a DC - SIGN1 - specific antiserum showed that DC-SIGN1 is expressed on endothelial cells and CC chemokine receptor 5 ( CCR5 ) - positive macrophage - like cells in the villi ."
],
"offsets": [
[
0,
212
]
]
}
]
| [
{
"id": "split_0_train_2395_entity",
"type": "progene_text",
"text": [
"DC - SIGN1"
],
"offsets": [
[
39,
49
]
],
"normalized": []
},
{
"id": "split_0_train_2396_entity",
"type": "progene_text",
"text": [
"DC-SIGN1"
],
"offsets": [
[
83,
91
]
],
"normalized": []
},
{
"id": "split_0_train_2397_entity",
"type": "progene_text",
"text": [
"CC chemokine receptor 5"
],
"offsets": [
[
130,
153
]
],
"normalized": []
},
{
"id": "split_0_train_2398_entity",
"type": "progene_text",
"text": [
"CCR5"
],
"offsets": [
[
156,
160
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1548 | split_0_train_1548 | [
{
"id": "split_0_train_1548_passage",
"type": "progene_text",
"text": [
"DC-SIGN2 mRNA expression was high in the placenta and not detectable in PBMCs ."
],
"offsets": [
[
0,
79
]
]
}
]
| [
{
"id": "split_0_train_2399_entity",
"type": "progene_text",
"text": [
"DC-SIGN2"
],
"offsets": [
[
0,
8
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1549 | split_0_train_1549 | [
{
"id": "split_0_train_1549_passage",
"type": "progene_text",
"text": [
"In DCs , the expression of DC-SIGN2 transcripts was significantly lower than that of DC-SIGN1 ."
],
"offsets": [
[
0,
95
]
]
}
]
| [
{
"id": "split_0_train_2400_entity",
"type": "progene_text",
"text": [
"DC-SIGN2"
],
"offsets": [
[
27,
35
]
],
"normalized": []
},
{
"id": "split_0_train_2401_entity",
"type": "progene_text",
"text": [
"DC-SIGN1"
],
"offsets": [
[
85,
93
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1550 | split_0_train_1550 | [
{
"id": "split_0_train_1550_passage",
"type": "progene_text",
"text": [
"Notably , there was significant inter - individual heterogeneity in the repertoire of DC-SIGN1 and DC-SIGN2 transcripts expressed ."
],
"offsets": [
[
0,
131
]
]
}
]
| [
{
"id": "split_0_train_2402_entity",
"type": "progene_text",
"text": [
"DC-SIGN1"
],
"offsets": [
[
86,
94
]
],
"normalized": []
},
{
"id": "split_0_train_2403_entity",
"type": "progene_text",
"text": [
"DC-SIGN2"
],
"offsets": [
[
99,
107
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1551 | split_0_train_1551 | [
{
"id": "split_0_train_1551_passage",
"type": "progene_text",
"text": [
"The genes for DC-SIGN1 , DC-SIGN2 , and CD23 , another Type II lectin , colocalize to an approximately 85 kilobase pair region on chromosome 19p13.3 , forming a cluster of related genes that undergo highly complex alternative splicing events ."
],
"offsets": [
[
0,
243
]
]
}
]
| [
{
"id": "split_0_train_2404_entity",
"type": "progene_text",
"text": [
"DC-SIGN1"
],
"offsets": [
[
14,
22
]
],
"normalized": []
},
{
"id": "split_0_train_2405_entity",
"type": "progene_text",
"text": [
"DC-SIGN2"
],
"offsets": [
[
25,
33
]
],
"normalized": []
},
{
"id": "split_0_train_2406_entity",
"type": "progene_text",
"text": [
"CD23"
],
"offsets": [
[
40,
44
]
],
"normalized": []
},
{
"id": "split_0_train_2407_entity",
"type": "progene_text",
"text": [
"Type II lectin"
],
"offsets": [
[
55,
69
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1552 | split_0_train_1552 | [
{
"id": "split_0_train_1552_passage",
"type": "progene_text",
"text": [
"The molecular diversity of DC-SIGN-1 and - 2 is reminiscent of that observed for certain other adhesive cell surface proteins involved in cell - cell connectivity ."
],
"offsets": [
[
0,
164
]
]
}
]
| [
{
"id": "split_0_train_2408_entity",
"type": "progene_text",
"text": [
"DC-SIGN-1 and - 2"
],
"offsets": [
[
27,
44
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1553 | split_0_train_1553 | [
{
"id": "split_0_train_1553_passage",
"type": "progene_text",
"text": [
"The generation of this large collection of polymorphic cell surface and soluble variants that exhibit inter - individual variation in expression levels has important implications for the pathogenesis of HIV-1 infection , as well as for the molecular code required to establish complex interactions between antigen - presenting cells and T cells , i.e. the immunological synapse ."
],
"offsets": [
[
0,
379
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1554 | split_0_train_1554 | [
{
"id": "split_0_train_1554_passage",
"type": "progene_text",
"text": [
"Protein tyrosine kinase regulates FAS - mediated apoptosis in human BCG - infected monocytes ."
],
"offsets": [
[
0,
94
]
]
}
]
| [
{
"id": "split_0_train_2409_entity",
"type": "progene_text",
"text": [
"Protein tyrosine kinase"
],
"offsets": [
[
0,
23
]
],
"normalized": []
},
{
"id": "split_0_train_2410_entity",
"type": "progene_text",
"text": [
"FAS"
],
"offsets": [
[
34,
37
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1555 | split_0_train_1555 | [
{
"id": "split_0_train_1555_passage",
"type": "progene_text",
"text": [
"Apoptosis of monocytes / macrophages has emerged as a central regulatory event in the defense against mycobacterial infections ."
],
"offsets": [
[
0,
128
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1556 | split_0_train_1556 | [
{
"id": "split_0_train_1556_passage",
"type": "progene_text",
"text": [
"The involvement of protein tyrosine kinases ( PTK ) in Fas - mediated apoptosis in T cells is well established , but the possible role of PTK in Fas - dependent death of human bacillus Calmette - Guerin ( BCG ) - infected monocytes remains unclear ."
],
"offsets": [
[
0,
249
]
]
}
]
| [
{
"id": "split_0_train_2411_entity",
"type": "progene_text",
"text": [
"protein tyrosine kinases"
],
"offsets": [
[
19,
43
]
],
"normalized": []
},
{
"id": "split_0_train_2412_entity",
"type": "progene_text",
"text": [
"PTK"
],
"offsets": [
[
46,
49
]
],
"normalized": []
},
{
"id": "split_0_train_2413_entity",
"type": "progene_text",
"text": [
"Fas"
],
"offsets": [
[
55,
58
]
],
"normalized": []
},
{
"id": "split_0_train_2414_entity",
"type": "progene_text",
"text": [
"PTK"
],
"offsets": [
[
138,
141
]
],
"normalized": []
},
{
"id": "split_0_train_2415_entity",
"type": "progene_text",
"text": [
"Fas"
],
"offsets": [
[
145,
148
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1557 | split_0_train_1557 | [
{
"id": "split_0_train_1557_passage",
"type": "progene_text",
"text": [
"Here , we first examined the expression and function of Fas on BCG - infected human monocytes by flow cytometry ."
],
"offsets": [
[
0,
113
]
]
}
]
| [
{
"id": "split_0_train_2416_entity",
"type": "progene_text",
"text": [
"Fas"
],
"offsets": [
[
56,
59
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1558 | split_0_train_1558 | [
{
"id": "split_0_train_1558_passage",
"type": "progene_text",
"text": [
"The results demonstrated that BCG - infected monocytes expressed significant Fas protein levels ."
],
"offsets": [
[
0,
97
]
]
}
]
| [
{
"id": "split_0_train_2417_entity",
"type": "progene_text",
"text": [
"Fas"
],
"offsets": [
[
77,
80
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1559 | split_0_train_1559 | [
{
"id": "split_0_train_1559_passage",
"type": "progene_text",
"text": [
"In addition , engagement of the Fas antigen with its agonistic antibody ( Ab ) resulted in apoptosis of monocytes , as monitored by DNA analysis and fluorescence - activated cell sorter ( FACS ) analysis ."
],
"offsets": [
[
0,
205
]
]
}
]
| [
{
"id": "split_0_train_2418_entity",
"type": "progene_text",
"text": [
"Fas"
],
"offsets": [
[
32,
35
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1560 | split_0_train_1560 | [
{
"id": "split_0_train_1560_passage",
"type": "progene_text",
"text": [
"The apoptotic action of Fas was suppressed significantly by genistein , indicating a role for PTK in this death process ."
],
"offsets": [
[
0,
121
]
]
}
]
| [
{
"id": "split_0_train_2419_entity",
"type": "progene_text",
"text": [
"Fas"
],
"offsets": [
[
24,
27
]
],
"normalized": []
},
{
"id": "split_0_train_2420_entity",
"type": "progene_text",
"text": [
"PTK"
],
"offsets": [
[
94,
97
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1561 | split_0_train_1561 | [
{
"id": "split_0_train_1561_passage",
"type": "progene_text",
"text": [
"Consistent with this observation , herbimycin A and tyrphostin , two selective tyrosine kinase inhibitors with different mechanisms of action , effectively inhibited Fas - mediated apoptosis of BCG - infected monocytes , as demonstrated by DNA content analysis ."
],
"offsets": [
[
0,
262
]
]
}
]
| [
{
"id": "split_0_train_2421_entity",
"type": "progene_text",
"text": [
"tyrosine kinase"
],
"offsets": [
[
79,
94
]
],
"normalized": []
},
{
"id": "split_0_train_2422_entity",
"type": "progene_text",
"text": [
"Fas"
],
"offsets": [
[
166,
169
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1562 | split_0_train_1562 | [
{
"id": "split_0_train_1562_passage",
"type": "progene_text",
"text": [
"Moreover , we confirmed the effect of genistein , herbimycin A , and tyrphostin by examining apoptosis with the terminal transferase dUTP nick endlabeling ( TUNEL ) assay ."
],
"offsets": [
[
0,
172
]
]
}
]
| [
{
"id": "split_0_train_2423_entity",
"type": "progene_text",
"text": [
"terminal transferase"
],
"offsets": [
[
112,
132
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1563 | split_0_train_1563 | [
{
"id": "split_0_train_1563_passage",
"type": "progene_text",
"text": [
"Collectively , these data demonstrate that Fas - induced apoptosis may represent an important mechanism for eliminating BCG - activated human monocytes and that this apoptosis is due , at least in part , to signaling via a PTK pathway ."
],
"offsets": [
[
0,
236
]
]
}
]
| [
{
"id": "split_0_train_2424_entity",
"type": "progene_text",
"text": [
"Fas"
],
"offsets": [
[
43,
46
]
],
"normalized": []
},
{
"id": "split_0_train_2425_entity",
"type": "progene_text",
"text": [
"PTK"
],
"offsets": [
[
223,
226
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1564 | split_0_train_1564 | [
{
"id": "split_0_train_1564_passage",
"type": "progene_text",
"text": [
"Genomic diversity of natural killer cell receptor genes in three populations ."
],
"offsets": [
[
0,
78
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1565 | split_0_train_1565 | [
{
"id": "split_0_train_1565_passage",
"type": "progene_text",
"text": [
"We report the distribution of genes encoding 11 killer cell immunoglobulin - like receptors ( KIR ) and 2 CD94 : NKG2 receptors , in 32 Caucasians , 67 Australian Aborigines and 59 Vietnamese ."
],
"offsets": [
[
0,
193
]
]
}
]
| [
{
"id": "split_0_train_2426_entity",
"type": "progene_text",
"text": [
"killer cell immunoglobulin - like receptors"
],
"offsets": [
[
48,
91
]
],
"normalized": []
},
{
"id": "split_0_train_2427_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
94,
97
]
],
"normalized": []
},
{
"id": "split_0_train_2428_entity",
"type": "progene_text",
"text": [
"CD94"
],
"offsets": [
[
106,
110
]
],
"normalized": []
},
{
"id": "split_0_train_2429_entity",
"type": "progene_text",
"text": [
"NKG2"
],
"offsets": [
[
113,
117
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1566 | split_0_train_1566 | [
{
"id": "split_0_train_1566_passage",
"type": "progene_text",
"text": [
"The inhibitory and the activating KIR genes were found at different frequency in the three populations ."
],
"offsets": [
[
0,
104
]
]
}
]
| [
{
"id": "split_0_train_2430_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
34,
37
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1567 | split_0_train_1567 | [
{
"id": "split_0_train_1567_passage",
"type": "progene_text",
"text": [
"No correlation was found between the polymorphism of the KIR genes and the HLA specificities of the tested samples ."
],
"offsets": [
[
0,
116
]
]
}
]
| [
{
"id": "split_0_train_2431_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
57,
60
]
],
"normalized": []
},
{
"id": "split_0_train_2432_entity",
"type": "progene_text",
"text": [
"HLA"
],
"offsets": [
[
75,
78
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1568 | split_0_train_1568 | [
{
"id": "split_0_train_1568_passage",
"type": "progene_text",
"text": [
"The most significant KIR associations were 2DL2 with 2DS2 ; 2DL2 with 2DS3 and 3DL1 with 2DS4 in all three study groups ."
],
"offsets": [
[
0,
121
]
]
}
]
| [
{
"id": "split_0_train_2433_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
21,
24
]
],
"normalized": []
},
{
"id": "split_0_train_2434_entity",
"type": "progene_text",
"text": [
"2DL2"
],
"offsets": [
[
43,
47
]
],
"normalized": []
},
{
"id": "split_0_train_2435_entity",
"type": "progene_text",
"text": [
"2DS2"
],
"offsets": [
[
53,
57
]
],
"normalized": []
},
{
"id": "split_0_train_2436_entity",
"type": "progene_text",
"text": [
"2DL2"
],
"offsets": [
[
60,
64
]
],
"normalized": []
},
{
"id": "split_0_train_2437_entity",
"type": "progene_text",
"text": [
"2DS3"
],
"offsets": [
[
70,
74
]
],
"normalized": []
},
{
"id": "split_0_train_2438_entity",
"type": "progene_text",
"text": [
"3DL1"
],
"offsets": [
[
79,
83
]
],
"normalized": []
},
{
"id": "split_0_train_2439_entity",
"type": "progene_text",
"text": [
"2DS4"
],
"offsets": [
[
89,
93
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1569 | split_0_train_1569 | [
{
"id": "split_0_train_1569_passage",
"type": "progene_text",
"text": [
"In Caucasians and Vietnamese 2DS2 was associated with 2DS3 and 2DS1with 3DS1 ."
],
"offsets": [
[
0,
78
]
]
}
]
| [
{
"id": "split_0_train_2440_entity",
"type": "progene_text",
"text": [
"2DS2"
],
"offsets": [
[
29,
33
]
],
"normalized": []
},
{
"id": "split_0_train_2441_entity",
"type": "progene_text",
"text": [
"2DS3"
],
"offsets": [
[
54,
58
]
],
"normalized": []
},
{
"id": "split_0_train_2442_entity",
"type": "progene_text",
"text": [
"2DS1with"
],
"offsets": [
[
63,
71
]
],
"normalized": []
},
{
"id": "split_0_train_2443_entity",
"type": "progene_text",
"text": [
"3DS1"
],
"offsets": [
[
72,
76
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1570 | split_0_train_1570 | [
{
"id": "split_0_train_1570_passage",
"type": "progene_text",
"text": [
"KIR 2DL1 was strongly associated with three other KIRs : 2DL3 , 3DL1 and 2DS4 in Aborigines ."
],
"offsets": [
[
0,
93
]
]
}
]
| [
{
"id": "split_0_train_2444_entity",
"type": "progene_text",
"text": [
"KIR 2DL1"
],
"offsets": [
[
0,
8
]
],
"normalized": []
},
{
"id": "split_0_train_2445_entity",
"type": "progene_text",
"text": [
"KIRs"
],
"offsets": [
[
50,
54
]
],
"normalized": []
},
{
"id": "split_0_train_2446_entity",
"type": "progene_text",
"text": [
"2DL3"
],
"offsets": [
[
57,
61
]
],
"normalized": []
},
{
"id": "split_0_train_2447_entity",
"type": "progene_text",
"text": [
"3DL1"
],
"offsets": [
[
64,
68
]
],
"normalized": []
},
{
"id": "split_0_train_2448_entity",
"type": "progene_text",
"text": [
"2DS4"
],
"offsets": [
[
73,
77
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1571 | split_0_train_1571 | [
{
"id": "split_0_train_1571_passage",
"type": "progene_text",
"text": [
"The distribution of the KIR phenotypes was different in the three populations ."
],
"offsets": [
[
0,
79
]
]
}
]
| [
{
"id": "split_0_train_2449_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
24,
27
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1572 | split_0_train_1572 | [
{
"id": "split_0_train_1572_passage",
"type": "progene_text",
"text": [
"The AA1 phenotype was frequent in Vietnamese ( 42.4 % ) and Caucasians ( 31.2 % ) , but very rare in Aborigines ( 1.5 % ) ."
],
"offsets": [
[
0,
123
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1573 | split_0_train_1573 | [
{
"id": "split_0_train_1573_passage",
"type": "progene_text",
"text": [
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]
| []
| []
| []
| []
|
split_0_train_1574 | split_0_train_1574 | [
{
"id": "split_0_train_1574_passage",
"type": "progene_text",
"text": [
"Our data demonstrate that different associations and putative KIR haplotypes could be distinguished in different populations ."
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0,
126
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| [
{
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"KIR"
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62,
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}
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| []
| []
| []
|
split_0_train_1575 | split_0_train_1575 | [
{
"id": "split_0_train_1575_passage",
"type": "progene_text",
"text": [
"Upregulation of bone morphogenetic protein GDF-3 / Vgr-2 expression in adipose tissue of FABP4 / aP2 null mice ."
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[
0,
112
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| [
{
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"type": "progene_text",
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16,
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{
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{
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{
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"aP2"
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97,
100
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}
]
| []
| []
| []
|
split_0_train_1576 | split_0_train_1576 | [
{
"id": "split_0_train_1576_passage",
"type": "progene_text",
"text": [
"High - fat - fed C57Bl / 6J FABP4 / aP2 null mice develop obesity but not the related hyperglycemia or hyperinsulinemia characteristic of type II diabetes ."
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0,
156
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| [
{
"id": "split_0_train_2456_entity",
"type": "progene_text",
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28,
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{
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[
36,
39
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}
]
| []
| []
| []
|
split_0_train_1577 | split_0_train_1577 | [
{
"id": "split_0_train_1577_passage",
"type": "progene_text",
"text": [
"FABP4 / aP2 protein 's function to bind fatty acids in the adipocytes may promote total body energy homeostasis by linking energy depots to the ability to express signaling molecules similar to leptin ."
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0,
202
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| [
{
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{
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{
"id": "split_0_train_2460_entity",
"type": "progene_text",
"text": [
"leptin"
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[
194,
200
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1578 | split_0_train_1578 | [
{
"id": "split_0_train_1578_passage",
"type": "progene_text",
"text": [
"To test this hypothesis , proteomic analysis of serum proteins from high - fat - fed wild - type and FABP4 / aP2 null mice revealed that the GDF-3 / Vgr-2 protein , a bone morphogenetic protein , was upregulated in C57Bl / 6J FABP4 / aP2 null mice ."
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[
0,
249
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| [
{
"id": "split_0_train_2461_entity",
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101,
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109,
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{
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141,
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{
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"type": "progene_text",
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149,
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{
"id": "split_0_train_2465_entity",
"type": "progene_text",
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167,
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{
"id": "split_0_train_2466_entity",
"type": "progene_text",
"text": [
"FABP4"
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226,
231
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},
{
"id": "split_0_train_2467_entity",
"type": "progene_text",
"text": [
"aP2"
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"offsets": [
[
234,
237
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1579 | split_0_train_1579 | [
{
"id": "split_0_train_1579_passage",
"type": "progene_text",
"text": [
"The increase in serum GDF-3 / Vgr-2 protein was correlated with a 27 - fold increase in adipose GDF-3 / Vgr-2 mRNA ."
],
"offsets": [
[
0,
116
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]
}
]
| [
{
"id": "split_0_train_2468_entity",
"type": "progene_text",
"text": [
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22,
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{
"id": "split_0_train_2469_entity",
"type": "progene_text",
"text": [
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30,
35
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{
"id": "split_0_train_2470_entity",
"type": "progene_text",
"text": [
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96,
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{
"id": "split_0_train_2471_entity",
"type": "progene_text",
"text": [
"Vgr-2"
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"offsets": [
[
104,
109
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1580 | split_0_train_1580 | [
{
"id": "split_0_train_1580_passage",
"type": "progene_text",
"text": [
"In contrast , leptin expression was unaltered between FABP4 / aP2 null and wild - type animals ."
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[
0,
96
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}
]
| [
{
"id": "split_0_train_2472_entity",
"type": "progene_text",
"text": [
"leptin"
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[
14,
20
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},
{
"id": "split_0_train_2473_entity",
"type": "progene_text",
"text": [
"FABP4"
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54,
59
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],
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},
{
"id": "split_0_train_2474_entity",
"type": "progene_text",
"text": [
"aP2"
],
"offsets": [
[
62,
65
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1581 | split_0_train_1581 | [
{
"id": "split_0_train_1581_passage",
"type": "progene_text",
"text": [
"The expression of GDF-3 / Vgr-2 mRNA was not substantially different in adipose tissue of db / db and tb / tb mice compared to wild - type controls ."
],
"offsets": [
[
0,
149
]
]
}
]
| [
{
"id": "split_0_train_2475_entity",
"type": "progene_text",
"text": [
"GDF-3"
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"offsets": [
[
18,
23
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},
{
"id": "split_0_train_2476_entity",
"type": "progene_text",
"text": [
"Vgr-2"
],
"offsets": [
[
26,
31
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1582 | split_0_train_1582 | [
{
"id": "split_0_train_1582_passage",
"type": "progene_text",
"text": [
"The expression of GDF-3 / Vgr-2 mRNA was dependent upon the age and diet of the animals , declining as a function of age in high - fat - fed wild - type animals while increasing in the FABP4 / aP2 null strain ."
],
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[
0,
210
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]
}
]
| [
{
"id": "split_0_train_2477_entity",
"type": "progene_text",
"text": [
"GDF-3"
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18,
23
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},
{
"id": "split_0_train_2478_entity",
"type": "progene_text",
"text": [
"Vgr-2"
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[
26,
31
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},
{
"id": "split_0_train_2479_entity",
"type": "progene_text",
"text": [
"FABP4"
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[
185,
190
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],
"normalized": []
},
{
"id": "split_0_train_2480_entity",
"type": "progene_text",
"text": [
"aP2"
],
"offsets": [
[
193,
196
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1583 | split_0_train_1583 | [
{
"id": "split_0_train_1583_passage",
"type": "progene_text",
"text": [
"These results identify GDF-3 / Vgr-2 as an age - and fat - regulated , adipose - derived cytokine suggesting a linkage between adipocyte fatty acid metabolism and the expression of the bone morphogenetic family of differentiation regulators ."
],
"offsets": [
[
0,
242
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]
}
]
| [
{
"id": "split_0_train_2481_entity",
"type": "progene_text",
"text": [
"GDF-3"
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23,
28
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},
{
"id": "split_0_train_2482_entity",
"type": "progene_text",
"text": [
"Vgr-2"
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[
31,
36
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"normalized": []
},
{
"id": "split_0_train_2483_entity",
"type": "progene_text",
"text": [
"cytokine"
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[
89,
97
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},
{
"id": "split_0_train_2484_entity",
"type": "progene_text",
"text": [
"bone morphogenetic family"
],
"offsets": [
[
185,
210
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1584 | split_0_train_1584 | [
{
"id": "split_0_train_1584_passage",
"type": "progene_text",
"text": [
"Yeast histone deposition protein Asf1p requires Hir proteins and PCNA for heterochromatic silencing ."
],
"offsets": [
[
0,
101
]
]
}
]
| [
{
"id": "split_0_train_2485_entity",
"type": "progene_text",
"text": [
"histone"
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"offsets": [
[
6,
13
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},
{
"id": "split_0_train_2486_entity",
"type": "progene_text",
"text": [
"Asf1p"
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"offsets": [
[
33,
38
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],
"normalized": []
},
{
"id": "split_0_train_2487_entity",
"type": "progene_text",
"text": [
"Hir"
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"offsets": [
[
48,
51
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],
"normalized": []
},
{
"id": "split_0_train_2488_entity",
"type": "progene_text",
"text": [
"PCNA"
],
"offsets": [
[
65,
69
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1585 | split_0_train_1585 | [
{
"id": "split_0_train_1585_passage",
"type": "progene_text",
"text": [
"BACKGROUND :"
],
"offsets": [
[
0,
12
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1586 | split_0_train_1586 | [
{
"id": "split_0_train_1586_passage",
"type": "progene_text",
"text": [
"Position - dependent gene silencing in yeast involves many factors , including the four HIR genes and nucleosome assembly proteins Asf1p and chromatin assembly factor I ( CAF-I , encoded by the CAC1 - 3 genes ) ."
],
"offsets": [
[
0,
212
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]
}
]
| [
{
"id": "split_0_train_2489_entity",
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"HIR"
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88,
91
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},
{
"id": "split_0_train_2490_entity",
"type": "progene_text",
"text": [
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102,
130
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},
{
"id": "split_0_train_2491_entity",
"type": "progene_text",
"text": [
"Asf1p"
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[
131,
136
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},
{
"id": "split_0_train_2492_entity",
"type": "progene_text",
"text": [
"chromatin assembly factor I"
],
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[
141,
168
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},
{
"id": "split_0_train_2493_entity",
"type": "progene_text",
"text": [
"CAF-I"
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[
171,
176
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],
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},
{
"id": "split_0_train_2494_entity",
"type": "progene_text",
"text": [
"CAC1 - 3"
],
"offsets": [
[
194,
202
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1587 | split_0_train_1587 | [
{
"id": "split_0_train_1587_passage",
"type": "progene_text",
"text": [
"Both cac Delta asfl Delta and cac Delta hir Delta double mutants display synergistic reductions in heterochromatic gene silencing ."
],
"offsets": [
[
0,
131
]
]
}
]
| [
{
"id": "split_0_train_2495_entity",
"type": "progene_text",
"text": [
"cac"
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"offsets": [
[
5,
8
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],
"normalized": []
},
{
"id": "split_0_train_2496_entity",
"type": "progene_text",
"text": [
"asfl"
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"offsets": [
[
15,
19
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],
"normalized": []
},
{
"id": "split_0_train_2497_entity",
"type": "progene_text",
"text": [
"cac"
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30,
33
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"normalized": []
},
{
"id": "split_0_train_2498_entity",
"type": "progene_text",
"text": [
"hir"
],
"offsets": [
[
40,
43
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1588 | split_0_train_1588 | [
{
"id": "split_0_train_1588_passage",
"type": "progene_text",
"text": [
"However , the relationship between the contributions of HIR genes and ASF1 to silencing has not previously been explored ."
],
"offsets": [
[
0,
122
]
]
}
]
| [
{
"id": "split_0_train_2499_entity",
"type": "progene_text",
"text": [
"HIR"
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"offsets": [
[
56,
59
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],
"normalized": []
},
{
"id": "split_0_train_2500_entity",
"type": "progene_text",
"text": [
"ASF1"
],
"offsets": [
[
70,
74
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1589 | split_0_train_1589 | [
{
"id": "split_0_train_1589_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1590 | split_0_train_1590 | [
{
"id": "split_0_train_1590_passage",
"type": "progene_text",
"text": [
"Our biochemical and genetic studies of yeast Asf1p revealed links to Hir protein function ."
],
"offsets": [
[
0,
91
]
]
}
]
| [
{
"id": "split_0_train_2501_entity",
"type": "progene_text",
"text": [
"Asf1p"
],
"offsets": [
[
45,
50
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],
"normalized": []
},
{
"id": "split_0_train_2502_entity",
"type": "progene_text",
"text": [
"Hir"
],
"offsets": [
[
69,
72
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1591 | split_0_train_1591 | [
{
"id": "split_0_train_1591_passage",
"type": "progene_text",
"text": [
"In vitro , an active histone deposition complex was formed from recombinant yeast Asf1p and histones H3 and H4 that lack a newly synthesized acetylation pattern ."
],
"offsets": [
[
0,
162
]
]
}
]
| [
{
"id": "split_0_train_2503_entity",
"type": "progene_text",
"text": [
"histone deposition complex"
],
"offsets": [
[
21,
47
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],
"normalized": []
},
{
"id": "split_0_train_2504_entity",
"type": "progene_text",
"text": [
"Asf1p"
],
"offsets": [
[
82,
87
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],
"normalized": []
},
{
"id": "split_0_train_2505_entity",
"type": "progene_text",
"text": [
"histones H3"
],
"offsets": [
[
92,
103
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],
"normalized": []
},
{
"id": "split_0_train_2506_entity",
"type": "progene_text",
"text": [
"H4"
],
"offsets": [
[
108,
110
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1592 | split_0_train_1592 | [
{
"id": "split_0_train_1592_passage",
"type": "progene_text",
"text": [
"This Asf1p / H3 / H4 complex generated micrococcal nuclease -- resistant DNA in the absence of DNA replication and stimulated nucleosome assembly activity by recombinant yeast CAF-I during DNA synthesis ."
],
"offsets": [
[
0,
204
]
]
}
]
| [
{
"id": "split_0_train_2507_entity",
"type": "progene_text",
"text": [
"Asf1p"
],
"offsets": [
[
5,
10
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],
"normalized": []
},
{
"id": "split_0_train_2508_entity",
"type": "progene_text",
"text": [
"H3"
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"offsets": [
[
13,
15
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],
"normalized": []
},
{
"id": "split_0_train_2509_entity",
"type": "progene_text",
"text": [
"H4"
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"offsets": [
[
18,
20
]
],
"normalized": []
},
{
"id": "split_0_train_2510_entity",
"type": "progene_text",
"text": [
"micrococcal nuclease"
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"offsets": [
[
39,
59
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],
"normalized": []
},
{
"id": "split_0_train_2511_entity",
"type": "progene_text",
"text": [
"CAF-I"
],
"offsets": [
[
176,
181
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1593 | split_0_train_1593 | [
{
"id": "split_0_train_1593_passage",
"type": "progene_text",
"text": [
"Also , Asf1p bound to the Hir1p and Hir2p proteins in vitro and in cell extracts ."
],
"offsets": [
[
0,
82
]
]
}
]
| [
{
"id": "split_0_train_2512_entity",
"type": "progene_text",
"text": [
"Asf1p"
],
"offsets": [
[
7,
12
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],
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},
{
"id": "split_0_train_2513_entity",
"type": "progene_text",
"text": [
"Hir1p"
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26,
31
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},
{
"id": "split_0_train_2514_entity",
"type": "progene_text",
"text": [
"Hir2p"
],
"offsets": [
[
36,
41
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1594 | split_0_train_1594 | [
{
"id": "split_0_train_1594_passage",
"type": "progene_text",
"text": [
"In vivo , the HIR1 and ASF1 genes contributed to silencing the heterochromatic HML locus via the same genetic pathway ."
],
"offsets": [
[
0,
119
]
]
}
]
| [
{
"id": "split_0_train_2515_entity",
"type": "progene_text",
"text": [
"HIR1"
],
"offsets": [
[
14,
18
]
],
"normalized": []
},
{
"id": "split_0_train_2516_entity",
"type": "progene_text",
"text": [
"ASF1"
],
"offsets": [
[
23,
27
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1595 | split_0_train_1595 | [
{
"id": "split_0_train_1595_passage",
"type": "progene_text",
"text": [
"Deletion of either HIR1 or ASF1 eliminated telomeric gene silencing in combination with pol30 -- 8 , encoding an altered form of the DNA polymerase processivity factor PCNA that prevents CAF-I from contributing to silencing ."
],
"offsets": [
[
0,
225
]
]
}
]
| [
{
"id": "split_0_train_2517_entity",
"type": "progene_text",
"text": [
"HIR1"
],
"offsets": [
[
19,
23
]
],
"normalized": []
},
{
"id": "split_0_train_2518_entity",
"type": "progene_text",
"text": [
"ASF1"
],
"offsets": [
[
27,
31
]
],
"normalized": []
},
{
"id": "split_0_train_2519_entity",
"type": "progene_text",
"text": [
"pol30"
],
"offsets": [
[
88,
93
]
],
"normalized": []
},
{
"id": "split_0_train_2520_entity",
"type": "progene_text",
"text": [
"DNA polymerase"
],
"offsets": [
[
133,
147
]
],
"normalized": []
},
{
"id": "split_0_train_2521_entity",
"type": "progene_text",
"text": [
"PCNA"
],
"offsets": [
[
168,
172
]
],
"normalized": []
},
{
"id": "split_0_train_2522_entity",
"type": "progene_text",
"text": [
"CAF-I"
],
"offsets": [
[
187,
192
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1596 | split_0_train_1596 | [
{
"id": "split_0_train_1596_passage",
"type": "progene_text",
"text": [
"Conversely , other pol30 alleles prevented Asf1 / Hir proteins from contributing to silencing ."
],
"offsets": [
[
0,
95
]
]
}
]
| [
{
"id": "split_0_train_2523_entity",
"type": "progene_text",
"text": [
"pol30"
],
"offsets": [
[
19,
24
]
],
"normalized": []
},
{
"id": "split_0_train_2524_entity",
"type": "progene_text",
"text": [
"Asf1"
],
"offsets": [
[
43,
47
]
],
"normalized": []
},
{
"id": "split_0_train_2525_entity",
"type": "progene_text",
"text": [
"Hir"
],
"offsets": [
[
50,
53
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1597 | split_0_train_1597 | [
{
"id": "split_0_train_1597_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1598 | split_0_train_1598 | [
{
"id": "split_0_train_1598_passage",
"type": "progene_text",
"text": [
"Yeast CAF-I and Asf1p cooperate to form nucleosomes in vitro ."
],
"offsets": [
[
0,
62
]
]
}
]
| [
{
"id": "split_0_train_2526_entity",
"type": "progene_text",
"text": [
"CAF-I"
],
"offsets": [
[
6,
11
]
],
"normalized": []
},
{
"id": "split_0_train_2527_entity",
"type": "progene_text",
"text": [
"Asf1p"
],
"offsets": [
[
16,
21
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1599 | split_0_train_1599 | [
{
"id": "split_0_train_1599_passage",
"type": "progene_text",
"text": [
"In vivo , Asf1p and Hir proteins physically interact and together promote heterochromatic gene silencing in a manner requiring PCNA ."
],
"offsets": [
[
0,
133
]
]
}
]
| [
{
"id": "split_0_train_2528_entity",
"type": "progene_text",
"text": [
"Asf1p"
],
"offsets": [
[
10,
15
]
],
"normalized": []
},
{
"id": "split_0_train_2529_entity",
"type": "progene_text",
"text": [
"Hir"
],
"offsets": [
[
20,
23
]
],
"normalized": []
},
{
"id": "split_0_train_2530_entity",
"type": "progene_text",
"text": [
"PCNA"
],
"offsets": [
[
127,
131
]
],
"normalized": []
}
]
| []
| []
| []
|
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