id
stringlengths 15
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| document_id
stringlengths 15
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| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_1700 | split_0_train_1700 | [
{
"id": "split_0_train_1700_passage",
"type": "progene_text",
"text": [
"To characterize the change of pH in the abomasal lumen throughout a 24 - hour period , to determine whether pH of the abomasal body differs from pH of the pyloric antrum , and to determine whether oral administration of cimetidine and ranitidine alters pH of the abomasal lumen in milk - fed calves ."
],
"offsets": [
[
0,
300
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1701 | split_0_train_1701 | [
{
"id": "split_0_train_1701_passage",
"type": "progene_text",
"text": [
"ANIMALS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1702 | split_0_train_1702 | [
{
"id": "split_0_train_1702_passage",
"type": "progene_text",
"text": [
"5 male dairy calves ( 4 Holsteins - Friesian , 1 Ayrshire ) , 5 to 15 days old ."
],
"offsets": [
[
0,
80
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1703 | split_0_train_1703 | [
{
"id": "split_0_train_1703_passage",
"type": "progene_text",
"text": [
"PROCEDURE :"
],
"offsets": [
[
0,
11
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1704 | split_0_train_1704 | [
{
"id": "split_0_train_1704_passage",
"type": "progene_text",
"text": [
"Cannulas were surgically positioned in the abomasal body and pyloric antrum of each calf ."
],
"offsets": [
[
0,
90
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1705 | split_0_train_1705 | [
{
"id": "split_0_train_1705_passage",
"type": "progene_text",
"text": [
"Calves received the following treatments in a randomized crossover design : milk replacer ( 60 ml / kg of body weight , q 12 h [ untreated control calves ] ) , milk replacer and cimetidine ( 50 or 100 mg / kg , q 8 h ) , or milk replacer and ranitidine ( 10 or 50 mg / kg , q 8 h ) ."
],
"offsets": [
[
0,
283
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1706 | split_0_train_1706 | [
{
"id": "split_0_train_1706_passage",
"type": "progene_text",
"text": [
"The pH of the abomasal body and pyloric antrum was measured for 24 hours , using miniature glass pH electrodes ."
],
"offsets": [
[
0,
112
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1707 | split_0_train_1707 | [
{
"id": "split_0_train_1707_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1708 | split_0_train_1708 | [
{
"id": "split_0_train_1708_passage",
"type": "progene_text",
"text": [
"Suckling of milk replacer immediately increased abomasal luminal pH from 1.4 to 6.0 , followed by a gradual decrease to preprandial values by 6 hours ."
],
"offsets": [
[
0,
151
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1709 | split_0_train_1709 | [
{
"id": "split_0_train_1709_passage",
"type": "progene_text",
"text": [
"Preprandial and postprandial pH values were not significantly different between the abomasal body and pyloric antrum , indicating lack of pH compartmentalization in the abomasum of milk - fed calves ."
],
"offsets": [
[
0,
200
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1710 | split_0_train_1710 | [
{
"id": "split_0_train_1710_passage",
"type": "progene_text",
"text": [
"Administration of cimetidine and ranitidine caused a significant dose - dependent increase in mean 24-hour abomasal luminal pH ."
],
"offsets": [
[
0,
128
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1711 | split_0_train_1711 | [
{
"id": "split_0_train_1711_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS AND CLINICAL RELEVANCE :"
],
"offsets": [
[
0,
36
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1712 | split_0_train_1712 | [
{
"id": "split_0_train_1712_passage",
"type": "progene_text",
"text": [
"Abomasal acid secretion in milk - fed calves is mediated in part by histamine type-2 receptors ."
],
"offsets": [
[
0,
96
]
]
}
]
| [
{
"id": "split_0_train_2681_entity",
"type": "progene_text",
"text": [
"histamine type-2 receptors"
],
"offsets": [
[
68,
94
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1713 | split_0_train_1713 | [
{
"id": "split_0_train_1713_passage",
"type": "progene_text",
"text": [
"Cimetidine and ranitidine may be efficacious in the treatment of abomasal ulcers in milk - fed calves ."
],
"offsets": [
[
0,
103
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1714 | split_0_train_1714 | [
{
"id": "split_0_train_1714_passage",
"type": "progene_text",
"text": [
"Effect of dietary intake before F-18 FDG positron emission tomographic scanning on the evaluation of a solitary pulmonary nodule ."
],
"offsets": [
[
0,
130
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1715 | split_0_train_1715 | [
{
"id": "split_0_train_1715_passage",
"type": "progene_text",
"text": [
"The uptake of fluorine-18 fluorodeoxyglucose ( F-18 FDG ) by a malignant tumor depends on the blood glucose level ."
],
"offsets": [
[
0,
115
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1716 | split_0_train_1716 | [
{
"id": "split_0_train_1716_passage",
"type": "progene_text",
"text": [
"The authors present a striking case that illustrates the importance of blood glucose measurement in F-18 FDG positron emission tomographic ( PET ) imaging in a patient with a solitary pulmonary nodule ."
],
"offsets": [
[
0,
202
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1717 | split_0_train_1717 | [
{
"id": "split_0_train_1717_passage",
"type": "progene_text",
"text": [
"With the emergence of freestanding imaging centers , this case emphasizes the importance of using an objective method , such as a glucometer , to measure blood glucose levels before F-18 FDG PET imaging ."
],
"offsets": [
[
0,
204
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1718 | split_0_train_1718 | [
{
"id": "split_0_train_1718_passage",
"type": "progene_text",
"text": [
"Results of the initial scan were equivocal ( the patient had eaten before the scan ) , whereas a hypermetabolic focus was clearly identified on a second scan obtained 2 days later ."
],
"offsets": [
[
0,
181
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1719 | split_0_train_1719 | [
{
"id": "split_0_train_1719_passage",
"type": "progene_text",
"text": [
"Isolation and characterization of a novel cDNA , UBAP1 , derived from the tumor suppressor locus in human chromosome 9p21 - 22 ."
],
"offsets": [
[
0,
128
]
]
}
]
| [
{
"id": "split_0_train_2682_entity",
"type": "progene_text",
"text": [
"UBAP1"
],
"offsets": [
[
49,
54
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1720 | split_0_train_1720 | [
{
"id": "split_0_train_1720_passage",
"type": "progene_text",
"text": [
"PURPOSE :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1721 | split_0_train_1721 | [
{
"id": "split_0_train_1721_passage",
"type": "progene_text",
"text": [
"To clone the putative tumor suppressor gene(s) in a refined region at 9p21-22 undergoing loss of heterozygosity in nasopharyngeal carcinoma ( NPC ) ."
],
"offsets": [
[
0,
149
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1722 | split_0_train_1722 | [
{
"id": "split_0_train_1722_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1723 | split_0_train_1723 | [
{
"id": "split_0_train_1723_passage",
"type": "progene_text",
"text": [
"We systematically screened the expression patterns of 25 novel ESTs ( expressed sequence tags ) in a minimal common deleted region of 9p21-22 in NPC ."
],
"offsets": [
[
0,
150
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1724 | split_0_train_1724 | [
{
"id": "split_0_train_1724_passage",
"type": "progene_text",
"text": [
"One of these ESTs was found down - regulated in NPC ."
],
"offsets": [
[
0,
53
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1725 | split_0_train_1725 | [
{
"id": "split_0_train_1725_passage",
"type": "progene_text",
"text": [
"Subsequently , the corresponding gene sequence of this EST was established by cDNA cloning and RACE ( rapid amplification of cDNA end ) procedures ."
],
"offsets": [
[
0,
148
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1726 | split_0_train_1726 | [
{
"id": "split_0_train_1726_passage",
"type": "progene_text",
"text": [
"Furthermore , a mouse homologue of this gene was identified ."
],
"offsets": [
[
0,
61
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1727 | split_0_train_1727 | [
{
"id": "split_0_train_1727_passage",
"type": "progene_text",
"text": [
"The expression of this gene was examined using Northern blot or reverse transcription - polymerase chain reaction ( RT - PCR ) in various human and mouse tissues ."
],
"offsets": [
[
0,
163
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1728 | split_0_train_1728 | [
{
"id": "split_0_train_1728_passage",
"type": "progene_text",
"text": [
"A limited screen for mutation of coding sequence of this novel human gene was undertaken using RT - PCR and direct sequencing analysis ."
],
"offsets": [
[
0,
136
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1729 | split_0_train_1729 | [
{
"id": "split_0_train_1729_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1730 | split_0_train_1730 | [
{
"id": "split_0_train_1730_passage",
"type": "progene_text",
"text": [
"A novel gene was cloned ."
],
"offsets": [
[
0,
25
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1731 | split_0_train_1731 | [
{
"id": "split_0_train_1731_passage",
"type": "progene_text",
"text": [
"This gene is a new member of the UBA domain family , so we named it UBAPI for ubiquitin - associated protein 1 ( HUGO Gene Nomenclature Committee - approved symbol ) ."
],
"offsets": [
[
0,
167
]
]
}
]
| [
{
"id": "split_0_train_2683_entity",
"type": "progene_text",
"text": [
"UBAPI"
],
"offsets": [
[
68,
73
]
],
"normalized": []
},
{
"id": "split_0_train_2684_entity",
"type": "progene_text",
"text": [
"ubiquitin - associated protein 1"
],
"offsets": [
[
78,
110
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1732 | split_0_train_1732 | [
{
"id": "split_0_train_1732_passage",
"type": "progene_text",
"text": [
"Northern blot and RT - PCR analysis demonstrate a ubiquitous pattern of gene expression in human and mouse tissues ."
],
"offsets": [
[
0,
116
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1733 | split_0_train_1733 | [
{
"id": "split_0_train_1733_passage",
"type": "progene_text",
"text": [
"The direct sequencing analysis of the coding region of hUBAP1 following RT - PCR failed to reveal any mutations in a preliminary screen of NPC cell line HNE1 and primary nasopharyngeal carcinoma samples ."
],
"offsets": [
[
0,
204
]
]
}
]
| [
{
"id": "split_0_train_2685_entity",
"type": "progene_text",
"text": [
"hUBAP1"
],
"offsets": [
[
55,
61
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1734 | split_0_train_1734 | [
{
"id": "split_0_train_1734_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1735 | split_0_train_1735 | [
{
"id": "split_0_train_1735_passage",
"type": "progene_text",
"text": [
"We cloned a novel gene UBAPI , which is highly conserved between human and mouse ."
],
"offsets": [
[
0,
82
]
]
}
]
| [
{
"id": "split_0_train_2686_entity",
"type": "progene_text",
"text": [
"UBAPI"
],
"offsets": [
[
23,
28
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1736 | split_0_train_1736 | [
{
"id": "split_0_train_1736_passage",
"type": "progene_text",
"text": [
"Clearly , as a novel member of UBA domain protein family and taking its map location into account , a more extensive analysis is essential to establish whether subtle mutations are present in nasopharyngeal carcinomas ."
],
"offsets": [
[
0,
219
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1737 | split_0_train_1737 | [
{
"id": "split_0_train_1737_passage",
"type": "progene_text",
"text": [
"Murine cysteine dioxygenase gene : structural organization , tissue - specific expression and promoter identification ."
],
"offsets": [
[
0,
119
]
]
}
]
| [
{
"id": "split_0_train_2687_entity",
"type": "progene_text",
"text": [
"cysteine dioxygenase"
],
"offsets": [
[
7,
27
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1738 | split_0_train_1738 | [
{
"id": "split_0_train_1738_passage",
"type": "progene_text",
"text": [
"The murine gene encoding cysteine dioxygenase ( CDO ; EC 1.13.11.20 ) , a key enzyme of L-cysteine metabolism , was isolated and characterized , and the proximal promoter was identified ."
],
"offsets": [
[
0,
187
]
]
}
]
| [
{
"id": "split_0_train_2688_entity",
"type": "progene_text",
"text": [
"cysteine dioxygenase"
],
"offsets": [
[
25,
45
]
],
"normalized": []
},
{
"id": "split_0_train_2689_entity",
"type": "progene_text",
"text": [
"CDO"
],
"offsets": [
[
48,
51
]
],
"normalized": []
},
{
"id": "split_0_train_2690_entity",
"type": "progene_text",
"text": [
"EC 1.13.11.20"
],
"offsets": [
[
54,
67
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1739 | split_0_train_1739 | [
{
"id": "split_0_train_1739_passage",
"type": "progene_text",
"text": [
"A bacterial artificial chromosome mouse library was screened and a single clone containing the entire CDO gene was isolated ."
],
"offsets": [
[
0,
125
]
]
}
]
| [
{
"id": "split_0_train_2691_entity",
"type": "progene_text",
"text": [
"CDO"
],
"offsets": [
[
102,
105
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1740 | split_0_train_1740 | [
{
"id": "split_0_train_1740_passage",
"type": "progene_text",
"text": [
"The murine CDO gene contains five exons and spans about 15 kb ."
],
"offsets": [
[
0,
63
]
]
}
]
| [
{
"id": "split_0_train_2692_entity",
"type": "progene_text",
"text": [
"CDO"
],
"offsets": [
[
11,
14
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1741 | split_0_train_1741 | [
{
"id": "split_0_train_1741_passage",
"type": "progene_text",
"text": [
"The open reading frame is encoded within all five exons ."
],
"offsets": [
[
0,
57
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1742 | split_0_train_1742 | [
{
"id": "split_0_train_1742_passage",
"type": "progene_text",
"text": [
"All intron / exon splice junctions and all intron sizes are conserved with the rat CDO gene and are very similar to those of the human CDO gene ."
],
"offsets": [
[
0,
145
]
]
}
]
| [
{
"id": "split_0_train_2693_entity",
"type": "progene_text",
"text": [
"CDO"
],
"offsets": [
[
83,
86
]
],
"normalized": []
},
{
"id": "split_0_train_2694_entity",
"type": "progene_text",
"text": [
"CDO"
],
"offsets": [
[
135,
138
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1743 | split_0_train_1743 | [
{
"id": "split_0_train_1743_passage",
"type": "progene_text",
"text": [
"The primary transcriptional initiation site is located 213 bp upstream of the initiation ATG codon ."
],
"offsets": [
[
0,
100
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1744 | split_0_train_1744 | [
{
"id": "split_0_train_1744_passage",
"type": "progene_text",
"text": [
"The nucleotide sequence of the 5'-promoter region is highly conserved between the mouse and rat genes and contains a TATA - box - like sequence and GC boxes ."
],
"offsets": [
[
0,
158
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1745 | split_0_train_1745 | [
{
"id": "split_0_train_1745_passage",
"type": "progene_text",
"text": [
"A variety of consensus cis - acting elements were also identified in the 5' - flanking region ."
],
"offsets": [
[
0,
95
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1746 | split_0_train_1746 | [
{
"id": "split_0_train_1746_passage",
"type": "progene_text",
"text": [
"These included HNF-3 beta , HFH-1 , HFH-2 , HFH-3 , C / EBP , and C/EBP beta , all of which are consistent with the tissue - specific expression profiles of the gene ."
],
"offsets": [
[
0,
167
]
]
}
]
| [
{
"id": "split_0_train_2695_entity",
"type": "progene_text",
"text": [
"HNF-3 beta"
],
"offsets": [
[
15,
25
]
],
"normalized": []
},
{
"id": "split_0_train_2696_entity",
"type": "progene_text",
"text": [
"HFH-1"
],
"offsets": [
[
28,
33
]
],
"normalized": []
},
{
"id": "split_0_train_2697_entity",
"type": "progene_text",
"text": [
"HFH-2"
],
"offsets": [
[
36,
41
]
],
"normalized": []
},
{
"id": "split_0_train_2698_entity",
"type": "progene_text",
"text": [
"HFH-3"
],
"offsets": [
[
44,
49
]
],
"normalized": []
},
{
"id": "split_0_train_2699_entity",
"type": "progene_text",
"text": [
"C / EBP"
],
"offsets": [
[
52,
59
]
],
"normalized": []
},
{
"id": "split_0_train_2700_entity",
"type": "progene_text",
"text": [
"C/EBP beta"
],
"offsets": [
[
66,
76
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1747 | split_0_train_1747 | [
{
"id": "split_0_train_1747_passage",
"type": "progene_text",
"text": [
"Gene reporter studies of the CDO 5' - region indicated the presence of an active promoter within the first 223 bp upstream of the transcriptional initiation site and the possible presence of repressor elements upstream of bp - 223 ."
],
"offsets": [
[
0,
232
]
]
}
]
| [
{
"id": "split_0_train_2701_entity",
"type": "progene_text",
"text": [
"CDO"
],
"offsets": [
[
29,
32
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1748 | split_0_train_1748 | [
{
"id": "split_0_train_1748_passage",
"type": "progene_text",
"text": [
"Northern blot analyses indicated that the CDO gene displays tissue - specific expression , with the highest mRNA level present in liver and with detectable levels found in kidney , lung , brain and small intestine ."
],
"offsets": [
[
0,
215
]
]
}
]
| [
{
"id": "split_0_train_2702_entity",
"type": "progene_text",
"text": [
"CDO"
],
"offsets": [
[
42,
45
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1749 | split_0_train_1749 | [
{
"id": "split_0_train_1749_passage",
"type": "progene_text",
"text": [
"Western blot analyses indicated that CDO protein levels parallel mRNA levels ."
],
"offsets": [
[
0,
78
]
]
}
]
| [
{
"id": "split_0_train_2703_entity",
"type": "progene_text",
"text": [
"CDO"
],
"offsets": [
[
37,
40
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1750 | split_0_train_1750 | [
{
"id": "split_0_train_1750_passage",
"type": "progene_text",
"text": [
"These results are consistent with the known function of CDO in whole - body cysteine homeostasis ."
],
"offsets": [
[
0,
98
]
]
}
]
| [
{
"id": "split_0_train_2704_entity",
"type": "progene_text",
"text": [
"CDO"
],
"offsets": [
[
56,
59
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1751 | split_0_train_1751 | [
{
"id": "split_0_train_1751_passage",
"type": "progene_text",
"text": [
"Isolation and culture of airway epithelial cells from chronically infected human lungs ."
],
"offsets": [
[
0,
88
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1752 | split_0_train_1752 | [
{
"id": "split_0_train_1752_passage",
"type": "progene_text",
"text": [
"We describe procedures for isolating and culturing airway epithelial cells from chronically infected human lungs ."
],
"offsets": [
[
0,
114
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1753 | split_0_train_1753 | [
{
"id": "split_0_train_1753_passage",
"type": "progene_text",
"text": [
"Experience in our laboratory demonstrated the need to balance pathogen eradication against antibiotic toxicity to epithelial cells ."
],
"offsets": [
[
0,
132
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1754 | split_0_train_1754 | [
{
"id": "split_0_train_1754_passage",
"type": "progene_text",
"text": [
"To provide a logical basis for antibiotic selection and dose , we systematically analyzed the cytotoxicity of antibiotics useful against typical pathogens ."
],
"offsets": [
[
0,
156
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1755 | split_0_train_1755 | [
{
"id": "split_0_train_1755_passage",
"type": "progene_text",
"text": [
"Alone , colistin , ciprofloxacin , doxycycline , and tobramycin were moderately toxic at concentrations close to those used in cell culture , whereas amphotericin , ceftazidime , chloramphenicol , imipenem , meropenem , piperacillin , sulfamethoxazole / trimethoprim , and vancomycin were nontoxic even at concentrations many times the antimicrobial level ."
],
"offsets": [
[
0,
357
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1756 | split_0_train_1756 | [
{
"id": "split_0_train_1756_passage",
"type": "progene_text",
"text": [
"Epithelial cytotoxicity of combined antibiotics was additive , with no evidence of competition or synergism ."
],
"offsets": [
[
0,
109
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1757 | split_0_train_1757 | [
{
"id": "split_0_train_1757_passage",
"type": "progene_text",
"text": [
"Antibiotics had little effect on initial cell attachment and did not acutely lyse cells , but inhibited subsequent growth ."
],
"offsets": [
[
0,
123
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1758 | split_0_train_1758 | [
{
"id": "split_0_train_1758_passage",
"type": "progene_text",
"text": [
"Interestingly , cytotoxicity decreased markedly with increasing epithelial cell density ."
],
"offsets": [
[
0,
89
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1759 | split_0_train_1759 | [
{
"id": "split_0_train_1759_passage",
"type": "progene_text",
"text": [
"Cystic fibrosis ( CF ) and non - CF epithelial cells showed no differences in sensitivity to the antibiotics tested and initial exposure to antibiotics did not affect the electrophysiologic properties of resistance or short circuit current in well - differentiated cells ."
],
"offsets": [
[
0,
272
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1760 | split_0_train_1760 | [
{
"id": "split_0_train_1760_passage",
"type": "progene_text",
"text": [
"Tailored combinations of antibiotics at appropriate doses killed even multidrug - resistant bacteria ."
],
"offsets": [
[
0,
102
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1761 | split_0_train_1761 | [
{
"id": "split_0_train_1761_passage",
"type": "progene_text",
"text": [
"Thus , epithelial cells can usually be cultured from chronically infected CF airways ."
],
"offsets": [
[
0,
86
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1762 | split_0_train_1762 | [
{
"id": "split_0_train_1762_passage",
"type": "progene_text",
"text": [
"Effects of crude oil spillage on growth and yield of maize ( Zea mays L. ) in soils of midwestern Nigeria ."
],
"offsets": [
[
0,
107
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1763 | split_0_train_1763 | [
{
"id": "split_0_train_1763_passage",
"type": "progene_text",
"text": [
"The effect of crude oil spillage on growth , productivity and nutrient uptake of maize ( Zea mays L. ) was assessed in a pot experiment using an Evwreni manifold sample of a petroleum development company , which had a specific gravity of 0.8778 ."
],
"offsets": [
[
0,
246
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1764 | split_0_train_1764 | [
{
"id": "split_0_train_1764_passage",
"type": "progene_text",
"text": [
"The Suwan 1 variety of maize was used in the experiment ."
],
"offsets": [
[
0,
57
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1765 | split_0_train_1765 | [
{
"id": "split_0_train_1765_passage",
"type": "progene_text",
"text": [
"In crude oil polluted soils , germination was delayed and the germination percentage was significantly affected by oil pollution ."
],
"offsets": [
[
0,
130
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1766 | split_0_train_1766 | [
{
"id": "split_0_train_1766_passage",
"type": "progene_text",
"text": [
"Growth was poor in polluted soils using parameters such as plant height , stem girth , ear height , leaf area at four weeks after planting , leaf area at maturity and average length of primary roots as growth indicators ."
],
"offsets": [
[
0,
221
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1767 | split_0_train_1767 | [
{
"id": "split_0_train_1767_passage",
"type": "progene_text",
"text": [
"Grain yield was significantly reduced at 95 % level of probability with yield ( when compared with the control ) reduced by as much as 98.6 % , 96.5 % and 58.3 % for preplant , five weeks after planting ( 5 WAP ) and seven weeks after planting ( 7 WAP ) treatments , respectively ."
],
"offsets": [
[
0,
281
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1768 | split_0_train_1768 | [
{
"id": "split_0_train_1768_passage",
"type": "progene_text",
"text": [
"Leaf analysis of the maize plants grown in soils contaminated with crude oil a week before planting ( preplant treatment ) revealed mean levels of heavy metals ( 6.18 ppm Zn2+ , 0.62 ppm Cu2+ , 26.24 ppm Fe2+ , 10.84 ppm Mn2+ , 2.96 ppm Pb2 + and 3.88 ppm Co2+ ) which are higher than the maximum permissible levels ( MPL ) for maize in tropical soils ."
],
"offsets": [
[
0,
353
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1769 | split_0_train_1769 | [
{
"id": "split_0_train_1769_passage",
"type": "progene_text",
"text": [
"Maize plants that were polluted at other time intervals showed no significant ( p > 0.05 ) variation in heavy metal concentrations when compared with the control , and were considered potentially safe for human consumption ."
],
"offsets": [
[
0,
224
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1770 | split_0_train_1770 | [
{
"id": "split_0_train_1770_passage",
"type": "progene_text",
"text": [
"Comparison of three methods for measuring PEG - hirudin in blood ."
],
"offsets": [
[
0,
66
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1771 | split_0_train_1771 | [
{
"id": "split_0_train_1771_passage",
"type": "progene_text",
"text": [
"Three methods for measuring pegylated hirudin ( PEG-hirudin ) , a new antithrombotic agent , in blood were compared using clinical samples ."
],
"offsets": [
[
0,
140
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1772 | split_0_train_1772 | [
{
"id": "split_0_train_1772_passage",
"type": "progene_text",
"text": [
"The ecarin clotting time ( ECT ) was performed in whole blood using a point - of - care device ( TAS analyzer ) ."
],
"offsets": [
[
0,
113
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1773 | split_0_train_1773 | [
{
"id": "split_0_train_1773_passage",
"type": "progene_text",
"text": [
"The ECT was also performed in plasma , using a clotting assay in a conventional automated coagulation analyzer ."
],
"offsets": [
[
0,
112
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1774 | split_0_train_1774 | [
{
"id": "split_0_train_1774_passage",
"type": "progene_text",
"text": [
"Finally , a chromogenic method was used , based on thrombin inhibition and the substrate S-2238 ."
],
"offsets": [
[
0,
97
]
]
}
]
| [
{
"id": "split_0_train_2705_entity",
"type": "progene_text",
"text": [
"thrombin"
],
"offsets": [
[
51,
59
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1775 | split_0_train_1775 | [
{
"id": "split_0_train_1775_passage",
"type": "progene_text",
"text": [
"Both clotting assays showed a linear relationship between the ECT and the PEG - hirudin concentration up to 3.0 microg / ml ."
],
"offsets": [
[
0,
125
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1776 | split_0_train_1776 | [
{
"id": "split_0_train_1776_passage",
"type": "progene_text",
"text": [
"The chromogenic substrate method was linear only between 0.1 and 1.0 microg / ml PEG - hirudin ."
],
"offsets": [
[
0,
96
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1777 | split_0_train_1777 | [
{
"id": "split_0_train_1777_passage",
"type": "progene_text",
"text": [
"The intra - assay coefficient of variation was 3.0 % for the automated ECT method , 6.4 % for the point - of - care ECT method and 3.4 % for the chromogenic method ."
],
"offsets": [
[
0,
165
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1778 | split_0_train_1778 | [
{
"id": "split_0_train_1778_passage",
"type": "progene_text",
"text": [
"The inter - assay coefficient of variation was approximately 10 % for both clotting methods and 3.2 % for the chromogenic method ."
],
"offsets": [
[
0,
130
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1779 | split_0_train_1779 | [
{
"id": "split_0_train_1779_passage",
"type": "progene_text",
"text": [
"There was a high correlation ( r = 0.954 ) in PEG-hirudin concentration between both ECT methods over the entire measuring range ."
],
"offsets": [
[
0,
130
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1780 | split_0_train_1780 | [
{
"id": "split_0_train_1780_passage",
"type": "progene_text",
"text": [
"The correlation of the chromogenic method with any ECT was significantly less ( r < 0.89 ) , even if only PEG - hirudin concentrations < 1.0 microg / ml were taken into account ( r < 0.92 ) ."
],
"offsets": [
[
0,
191
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1781 | split_0_train_1781 | [
{
"id": "split_0_train_1781_passage",
"type": "progene_text",
"text": [
"Although we clearly prefer the conventional ECT , any of the other methods may be used for monitoring PEG-hirudin in patients treated with this drug , depending on the specific application and local circumstances ."
],
"offsets": [
[
0,
214
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1782 | split_0_train_1782 | [
{
"id": "split_0_train_1782_passage",
"type": "progene_text",
"text": [
"Rna15 interaction with the A - rich yeast polyadenylation signal is an essential step in mRNA 3' - end formation ."
],
"offsets": [
[
0,
114
]
]
}
]
| [
{
"id": "split_0_train_2706_entity",
"type": "progene_text",
"text": [
"Rna15"
],
"offsets": [
[
0,
5
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1783 | split_0_train_1783 | [
{
"id": "split_0_train_1783_passage",
"type": "progene_text",
"text": [
"In Saccharomyces cerevisiae , four factors [ cleavage factor I ( CF I ) , CF II , polyadenylation factor I ( PF I ) , and poly ( A ) polymerase ( PAP ) ] are required for maturation of the 3 ' end of the mRNA ."
],
"offsets": [
[
0,
210
]
]
}
]
| [
{
"id": "split_0_train_2707_entity",
"type": "progene_text",
"text": [
"cleavage factor I"
],
"offsets": [
[
45,
62
]
],
"normalized": []
},
{
"id": "split_0_train_2708_entity",
"type": "progene_text",
"text": [
"CF I"
],
"offsets": [
[
65,
69
]
],
"normalized": []
},
{
"id": "split_0_train_2709_entity",
"type": "progene_text",
"text": [
"CF II"
],
"offsets": [
[
74,
79
]
],
"normalized": []
},
{
"id": "split_0_train_2710_entity",
"type": "progene_text",
"text": [
"polyadenylation factor I"
],
"offsets": [
[
82,
106
]
],
"normalized": []
},
{
"id": "split_0_train_2711_entity",
"type": "progene_text",
"text": [
"PF I"
],
"offsets": [
[
109,
113
]
],
"normalized": []
},
{
"id": "split_0_train_2712_entity",
"type": "progene_text",
"text": [
"poly ( A ) polymerase"
],
"offsets": [
[
122,
143
]
],
"normalized": []
},
{
"id": "split_0_train_2713_entity",
"type": "progene_text",
"text": [
"PAP"
],
"offsets": [
[
146,
149
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1784 | split_0_train_1784 | [
{
"id": "split_0_train_1784_passage",
"type": "progene_text",
"text": [
"CF I and CF II are required for cleavage ; a complex of PAP and PF I , which includes CF II subunits , participates in polyadenylation , along with CF I ."
],
"offsets": [
[
0,
154
]
]
}
]
| [
{
"id": "split_0_train_2714_entity",
"type": "progene_text",
"text": [
"CF I"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_2715_entity",
"type": "progene_text",
"text": [
"CF II"
],
"offsets": [
[
9,
14
]
],
"normalized": []
},
{
"id": "split_0_train_2716_entity",
"type": "progene_text",
"text": [
"PAP"
],
"offsets": [
[
56,
59
]
],
"normalized": []
},
{
"id": "split_0_train_2717_entity",
"type": "progene_text",
"text": [
"PF I"
],
"offsets": [
[
64,
68
]
],
"normalized": []
},
{
"id": "split_0_train_2718_entity",
"type": "progene_text",
"text": [
"CF II"
],
"offsets": [
[
86,
91
]
],
"normalized": []
},
{
"id": "split_0_train_2719_entity",
"type": "progene_text",
"text": [
"CF I"
],
"offsets": [
[
148,
152
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1785 | split_0_train_1785 | [
{
"id": "split_0_train_1785_passage",
"type": "progene_text",
"text": [
"These factors are directed to the appropriate site on the mRNA by two sequences : one A - rich and one UA - rich ."
],
"offsets": [
[
0,
114
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1786 | split_0_train_1786 | [
{
"id": "split_0_train_1786_passage",
"type": "progene_text",
"text": [
"CF I contains five proteins , two of which , Rna15 and Hrp1 , interact with the mRNA through RNA recognition motif - type RNA binding motifs ."
],
"offsets": [
[
0,
142
]
]
}
]
| [
{
"id": "split_0_train_2720_entity",
"type": "progene_text",
"text": [
"CF I"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_2721_entity",
"type": "progene_text",
"text": [
"Rna15"
],
"offsets": [
[
45,
50
]
],
"normalized": []
},
{
"id": "split_0_train_2722_entity",
"type": "progene_text",
"text": [
"Hrp1"
],
"offsets": [
[
55,
59
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1787 | split_0_train_1787 | [
{
"id": "split_0_train_1787_passage",
"type": "progene_text",
"text": [
"Previous work demonstrated that the UV cross - linking of purified Hrp1 to RNA required the UA - rich element , but the contact point of Rna15 was not known ."
],
"offsets": [
[
0,
158
]
]
}
]
| [
{
"id": "split_0_train_2723_entity",
"type": "progene_text",
"text": [
"Hrp1"
],
"offsets": [
[
67,
71
]
],
"normalized": []
},
{
"id": "split_0_train_2724_entity",
"type": "progene_text",
"text": [
"Rna15"
],
"offsets": [
[
137,
142
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1788 | split_0_train_1788 | [
{
"id": "split_0_train_1788_passage",
"type": "progene_text",
"text": [
"We show here that Rna15 does not recognize a particular sequence in the absence of other proteins ."
],
"offsets": [
[
0,
99
]
]
}
]
| [
{
"id": "split_0_train_2725_entity",
"type": "progene_text",
"text": [
"Rna15"
],
"offsets": [
[
18,
23
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1789 | split_0_train_1789 | [
{
"id": "split_0_train_1789_passage",
"type": "progene_text",
"text": [
"However , in complex with Hrp1 and Rna14 , Rna15 specifically interacts with the A - rich element ."
],
"offsets": [
[
0,
99
]
]
}
]
| [
{
"id": "split_0_train_2726_entity",
"type": "progene_text",
"text": [
"Hrp1"
],
"offsets": [
[
26,
30
]
],
"normalized": []
},
{
"id": "split_0_train_2727_entity",
"type": "progene_text",
"text": [
"Rna14"
],
"offsets": [
[
35,
40
]
],
"normalized": []
},
{
"id": "split_0_train_2728_entity",
"type": "progene_text",
"text": [
"Rna15"
],
"offsets": [
[
43,
48
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1790 | split_0_train_1790 | [
{
"id": "split_0_train_1790_passage",
"type": "progene_text",
"text": [
"The Pcf11 and Clp1 subunits of CF I are not needed to position Rna15 at this site ."
],
"offsets": [
[
0,
83
]
]
}
]
| [
{
"id": "split_0_train_2729_entity",
"type": "progene_text",
"text": [
"Pcf11"
],
"offsets": [
[
4,
9
]
],
"normalized": []
},
{
"id": "split_0_train_2730_entity",
"type": "progene_text",
"text": [
"Clp1"
],
"offsets": [
[
14,
18
]
],
"normalized": []
},
{
"id": "split_0_train_2731_entity",
"type": "progene_text",
"text": [
"CF I"
],
"offsets": [
[
31,
35
]
],
"normalized": []
},
{
"id": "split_0_train_2732_entity",
"type": "progene_text",
"text": [
"Rna15"
],
"offsets": [
[
63,
68
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1791 | split_0_train_1791 | [
{
"id": "split_0_train_1791_passage",
"type": "progene_text",
"text": [
"This interaction is essential to the function of CF I ."
],
"offsets": [
[
0,
55
]
]
}
]
| [
{
"id": "split_0_train_2733_entity",
"type": "progene_text",
"text": [
"CF I"
],
"offsets": [
[
49,
53
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1792 | split_0_train_1792 | [
{
"id": "split_0_train_1792_passage",
"type": "progene_text",
"text": [
"A mutant Rna15 with decreased affinity for RNA is defective for in vitro RNA processing and lethal in vivo , while an RNA with a mutation in the A - rich element is not processed in vitro and can no longer be UV cross - linked to the Rna15 subunit assembled into CF I ."
],
"offsets": [
[
0,
269
]
]
}
]
| [
{
"id": "split_0_train_2734_entity",
"type": "progene_text",
"text": [
"Rna15"
],
"offsets": [
[
9,
14
]
],
"normalized": []
},
{
"id": "split_0_train_2735_entity",
"type": "progene_text",
"text": [
"Rna15"
],
"offsets": [
[
234,
239
]
],
"normalized": []
},
{
"id": "split_0_train_2736_entity",
"type": "progene_text",
"text": [
"CF I"
],
"offsets": [
[
263,
267
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1793 | split_0_train_1793 | [
{
"id": "split_0_train_1793_passage",
"type": "progene_text",
"text": [
"Thus , the recognition of the A - rich element depends on the tethering of Rna15 through an Rna14 bridge to Hrp1 bound to the UA - rich motif ."
],
"offsets": [
[
0,
143
]
]
}
]
| [
{
"id": "split_0_train_2737_entity",
"type": "progene_text",
"text": [
"Rna15"
],
"offsets": [
[
75,
80
]
],
"normalized": []
},
{
"id": "split_0_train_2738_entity",
"type": "progene_text",
"text": [
"Rna14"
],
"offsets": [
[
92,
97
]
],
"normalized": []
},
{
"id": "split_0_train_2739_entity",
"type": "progene_text",
"text": [
"Hrp1"
],
"offsets": [
[
108,
112
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1794 | split_0_train_1794 | [
{
"id": "split_0_train_1794_passage",
"type": "progene_text",
"text": [
"These results illustrate that the yeast 3' end is defined and processed by a mechanism surprisingly different from that used by the mammalian system ."
],
"offsets": [
[
0,
150
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1795 | split_0_train_1795 | [
{
"id": "split_0_train_1795_passage",
"type": "progene_text",
"text": [
"Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism ."
],
"offsets": [
[
0,
91
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1796 | split_0_train_1796 | [
{
"id": "split_0_train_1796_passage",
"type": "progene_text",
"text": [
"The whole genome approach enables the characterization of all components of any given biological pathway ."
],
"offsets": [
[
0,
106
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1797 | split_0_train_1797 | [
{
"id": "split_0_train_1797_passage",
"type": "progene_text",
"text": [
"Moreover , it can help to uncover all the metabolic routes for any molecule ."
],
"offsets": [
[
0,
77
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1798 | split_0_train_1798 | [
{
"id": "split_0_train_1798_passage",
"type": "progene_text",
"text": [
"Here we have used the genome of Drosophila melanogaster to search for enzymes involved in the metabolism of fucosylated glycans ."
],
"offsets": [
[
0,
129
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1799 | split_0_train_1799 | [
{
"id": "split_0_train_1799_passage",
"type": "progene_text",
"text": [
"Our results suggest that in the fruit fly GDP-fucose , the donor for fucosyltransferase reactions , is formed exclusively via the de novo pathway from GDP-mannose through enzymatic reactions catalyzed by GDP-D-mannose 4,6-dehydratase ( GMD ) and GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase/4-reductase ( GMER , also known as FX in man ) ."
],
"offsets": [
[
0,
337
]
]
}
]
| [
{
"id": "split_0_train_2740_entity",
"type": "progene_text",
"text": [
"fucosyltransferase"
],
"offsets": [
[
69,
87
]
],
"normalized": []
},
{
"id": "split_0_train_2741_entity",
"type": "progene_text",
"text": [
"GDP-D-mannose 4,6-dehydratase"
],
"offsets": [
[
204,
233
]
],
"normalized": []
},
{
"id": "split_0_train_2742_entity",
"type": "progene_text",
"text": [
"GMD"
],
"offsets": [
[
236,
239
]
],
"normalized": []
},
{
"id": "split_0_train_2743_entity",
"type": "progene_text",
"text": [
"GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase/4-reductase"
],
"offsets": [
[
246,
300
]
],
"normalized": []
},
{
"id": "split_0_train_2744_entity",
"type": "progene_text",
"text": [
"GMER"
],
"offsets": [
[
303,
307
]
],
"normalized": []
},
{
"id": "split_0_train_2745_entity",
"type": "progene_text",
"text": [
"FX"
],
"offsets": [
[
324,
326
]
],
"normalized": []
}
]
| []
| []
| []
|
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