id
stringlengths 15
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| document_id
stringlengths 15
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| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_1900 | split_0_train_1900 | [
{
"id": "split_0_train_1900_passage",
"type": "progene_text",
"text": [
"Ibuprofen interference in the determination of 3-phenoxybenzoic acid in urine ."
],
"offsets": [
[
0,
79
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1901 | split_0_train_1901 | [
{
"id": "split_0_train_1901_passage",
"type": "progene_text",
"text": [
"Pyrethroid insecticides are widely used in agriculture and private households ."
],
"offsets": [
[
0,
79
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1902 | split_0_train_1902 | [
{
"id": "split_0_train_1902_passage",
"type": "progene_text",
"text": [
"Analysis of urine for pyrethroid metabolites is one way to detect human exposure to these insecticides and is carried out regularly as part of the Occupational and Environmental Medicine Monitoring Program recommended by the Deutsche Forschungsgemeinschaft ( DFG ) ."
],
"offsets": [
[
0,
266
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1903 | split_0_train_1903 | [
{
"id": "split_0_train_1903_passage",
"type": "progene_text",
"text": [
"Samples are analyzed using GC - MS ( selected ion monitoring ) following acid hydrolysis , solid phase extraction , esterification with methanol / sulfuric acid , and liquid - liquid extraction ."
],
"offsets": [
[
0,
195
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1904 | split_0_train_1904 | [
{
"id": "split_0_train_1904_passage",
"type": "progene_text",
"text": [
"The metabolite , 3-phenoxybenzoic acid ( 3-PBA ) , can be derived from several pyrethroids and is , therefore , a useful diagnostic analyte ; however , the presence of the over-the-counter drug , ibuprofen ((R,S)-2-(4-isobutylphenyl ) propionic acid ) , interferes with this determination , even after the ingestion of only one 200 - mg tablet ."
],
"offsets": [
[
0,
345
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1905 | split_0_train_1905 | [
{
"id": "split_0_train_1905_passage",
"type": "progene_text",
"text": [
"The interfering analyte is carboxy - ibuprofen which is not removed by the cleanup step ."
],
"offsets": [
[
0,
89
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1906 | split_0_train_1906 | [
{
"id": "split_0_train_1906_passage",
"type": "progene_text",
"text": [
"Experimental work shows that it takes two days for most of the ibuprofen to clear the body before 3-PBA can reliably be determined in urine ."
],
"offsets": [
[
0,
141
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1907 | split_0_train_1907 | [
{
"id": "split_0_train_1907_passage",
"type": "progene_text",
"text": [
"Prediction of Streptococcus salivarius subsp. thermophilus and Lactobacillus delbrueckii subsp. bulgaricus populations in yoghurt by Curie point pyrolysis - mass spectrometry ."
],
"offsets": [
[
0,
176
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1908 | split_0_train_1908 | [
{
"id": "split_0_train_1908_passage",
"type": "progene_text",
"text": [
"We evaluated the potential of pyrolysis - mass spectrometry ( PyMS ) for quantifying the binary mixed population of Streptococcus salivarius subsp. thermophilus and Lactobacillus delbrueckii subsp. bulgaricus in yoghurt ."
],
"offsets": [
[
0,
221
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1909 | split_0_train_1909 | [
{
"id": "split_0_train_1909_passage",
"type": "progene_text",
"text": [
"For this purpose , a new analytical approach was developed ."
],
"offsets": [
[
0,
60
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1910 | split_0_train_1910 | [
{
"id": "split_0_train_1910_passage",
"type": "progene_text",
"text": [
"The yoghurt was transparised and its total bacterial population was recovered by centrifugation and estimated by turbidimetric measurement ."
],
"offsets": [
[
0,
140
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1911 | split_0_train_1911 | [
{
"id": "split_0_train_1911_passage",
"type": "progene_text",
"text": [
"The quantity of each population ( L. bulgaricus , S. thermophilus ) was then estimated in the pellet by PyMS , and the data were analysed by artificial neural networks ( ANNs ) ."
],
"offsets": [
[
0,
178
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1912 | split_0_train_1912 | [
{
"id": "split_0_train_1912_passage",
"type": "progene_text",
"text": [
"In parallel , streptococci and lactobacilli were numerated on SYL agar and these data were used as reference values to predict the bacterial counts of each population by PyMS ."
],
"offsets": [
[
0,
176
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1913 | split_0_train_1913 | [
{
"id": "split_0_train_1913_passage",
"type": "progene_text",
"text": [
"A close correlation was established between the streptococci and the lactobacilli counts on SYL agar and PyMS measurements ( r(2) = 0.98 for S. thermophilus and r(2) = 0.96 for L. bulgaricus ) ."
],
"offsets": [
[
0,
194
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1914 | split_0_train_1914 | [
{
"id": "split_0_train_1914_passage",
"type": "progene_text",
"text": [
"Combined turbidimetric measurement and PyMS / ANNs seemed to be a powerful method for obtaining rapid counts of binary mixtures of bacteria in yoghurt ."
],
"offsets": [
[
0,
152
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1915 | split_0_train_1915 | [
{
"id": "split_0_train_1915_passage",
"type": "progene_text",
"text": [
"The molar ratio of serum retinol - binding protein ( RBP ) to transthyretin ( TTR ) is not useful to assess vitamin A status during infection in hospitalised children ."
],
"offsets": [
[
0,
168
]
]
}
]
| [
{
"id": "split_0_train_2914_entity",
"type": "progene_text",
"text": [
"retinol - binding protein"
],
"offsets": [
[
25,
50
]
],
"normalized": []
},
{
"id": "split_0_train_2915_entity",
"type": "progene_text",
"text": [
"RBP"
],
"offsets": [
[
53,
56
]
],
"normalized": []
},
{
"id": "split_0_train_2916_entity",
"type": "progene_text",
"text": [
"transthyretin"
],
"offsets": [
[
62,
75
]
],
"normalized": []
},
{
"id": "split_0_train_2917_entity",
"type": "progene_text",
"text": [
"TTR"
],
"offsets": [
[
78,
81
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1916 | split_0_train_1916 | [
{
"id": "split_0_train_1916_passage",
"type": "progene_text",
"text": [
"OBJECTIVE :"
],
"offsets": [
[
0,
11
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1917 | split_0_train_1917 | [
{
"id": "split_0_train_1917_passage",
"type": "progene_text",
"text": [
"To assess the usefulness of the molar ratio of serum retinol - binding protein ( RBP ) to transthyretin ( TTR ) to determine vitamin A ( VA ) status during infection ."
],
"offsets": [
[
0,
167
]
]
}
]
| [
{
"id": "split_0_train_2918_entity",
"type": "progene_text",
"text": [
"retinol - binding protein"
],
"offsets": [
[
53,
78
]
],
"normalized": []
},
{
"id": "split_0_train_2919_entity",
"type": "progene_text",
"text": [
"RBP"
],
"offsets": [
[
81,
84
]
],
"normalized": []
},
{
"id": "split_0_train_2920_entity",
"type": "progene_text",
"text": [
"transthyretin"
],
"offsets": [
[
90,
103
]
],
"normalized": []
},
{
"id": "split_0_train_2921_entity",
"type": "progene_text",
"text": [
"TTR"
],
"offsets": [
[
106,
109
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1918 | split_0_train_1918 | [
{
"id": "split_0_train_1918_passage",
"type": "progene_text",
"text": [
"DESIGN :"
],
"offsets": [
[
0,
8
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1919 | split_0_train_1919 | [
{
"id": "split_0_train_1919_passage",
"type": "progene_text",
"text": [
"We took advantage of previously collected data during a randomised double - blind , placebo - controlled clinical trial to conduct a secondary analysis of the RBP / TTR ratio and its relationship to infection and VA status ."
],
"offsets": [
[
0,
224
]
]
}
]
| [
{
"id": "split_0_train_2922_entity",
"type": "progene_text",
"text": [
"RBP"
],
"offsets": [
[
159,
162
]
],
"normalized": []
},
{
"id": "split_0_train_2923_entity",
"type": "progene_text",
"text": [
"TTR"
],
"offsets": [
[
165,
168
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1920 | split_0_train_1920 | [
{
"id": "split_0_train_1920_passage",
"type": "progene_text",
"text": [
"In this clinical trial , children were randomly assigned to one of three groups and received either one single oral high dose of VA ( 200 000 IU ) on the day of admission and subsequently a placebo daily until discharge or daily oral low doses of VA ( 5000 IU ) from admission until discharge or a placebo daily from admission until discharge ."
],
"offsets": [
[
0,
344
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1921 | split_0_train_1921 | [
{
"id": "split_0_train_1921_passage",
"type": "progene_text",
"text": [
"SETTING :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1922 | split_0_train_1922 | [
{
"id": "split_0_train_1922_passage",
"type": "progene_text",
"text": [
"Lwiro pediatric hospital , Province of South Kivu , Democratic Republic of Congo ."
],
"offsets": [
[
0,
82
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1923 | split_0_train_1923 | [
{
"id": "split_0_train_1923_passage",
"type": "progene_text",
"text": [
"SUBJECTS :"
],
"offsets": [
[
0,
10
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1924 | split_0_train_1924 | [
{
"id": "split_0_train_1924_passage",
"type": "progene_text",
"text": [
"A total of 900 children aged 0 - 72 months hospitalised consecutively between March 1994 and March 1996 ."
],
"offsets": [
[
0,
105
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1925 | split_0_train_1925 | [
{
"id": "split_0_train_1925_passage",
"type": "progene_text",
"text": [
"MAIN OUTCOME MEASURES :"
],
"offsets": [
[
0,
23
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1926 | split_0_train_1926 | [
{
"id": "split_0_train_1926_passage",
"type": "progene_text",
"text": [
"RBP / TTR molar ratio after 7 days hospitalisation ."
],
"offsets": [
[
0,
52
]
]
}
]
| [
{
"id": "split_0_train_2924_entity",
"type": "progene_text",
"text": [
"RBP"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_2925_entity",
"type": "progene_text",
"text": [
"TTR"
],
"offsets": [
[
6,
9
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1927 | split_0_train_1927 | [
{
"id": "split_0_train_1927_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1928 | split_0_train_1928 | [
{
"id": "split_0_train_1928_passage",
"type": "progene_text",
"text": [
"After 7 days hospitalisation , molar RBP : TTR ratio ( mean + / - s.d. ) of infected children ( C - reactive proteins > 10 mg / l ) was 0.67 +/- 0.31 in the high - dose group ( n = 81 ) , 0.74 +/- 0.44 in the low dose group ( n = 71 ) and 0.73 +/- 0.39 in the placebo group ( n = 81 ) ."
],
"offsets": [
[
0,
286
]
]
}
]
| [
{
"id": "split_0_train_2926_entity",
"type": "progene_text",
"text": [
"RBP"
],
"offsets": [
[
37,
40
]
],
"normalized": []
},
{
"id": "split_0_train_2927_entity",
"type": "progene_text",
"text": [
"TTR"
],
"offsets": [
[
43,
46
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1929 | split_0_train_1929 | [
{
"id": "split_0_train_1929_passage",
"type": "progene_text",
"text": [
"These values did not differ significantly ( one - way ANOVA P = 0.472 ) ."
],
"offsets": [
[
0,
73
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1930 | split_0_train_1930 | [
{
"id": "split_0_train_1930_passage",
"type": "progene_text",
"text": [
"In patients with baseline serum retinol concentrations < 0.70 micromol / l , changes in RBP : TTR ratio between admission and day 7 were not statistically different in the three groups ( one - way ANOVA P = 0.548 ) ."
],
"offsets": [
[
0,
216
]
]
}
]
| [
{
"id": "split_0_train_2928_entity",
"type": "progene_text",
"text": [
"RBP"
],
"offsets": [
[
88,
91
]
],
"normalized": []
},
{
"id": "split_0_train_2929_entity",
"type": "progene_text",
"text": [
"TTR"
],
"offsets": [
[
94,
97
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1931 | split_0_train_1931 | [
{
"id": "split_0_train_1931_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1932 | split_0_train_1932 | [
{
"id": "split_0_train_1932_passage",
"type": "progene_text",
"text": [
"In this population of malnourished hospitalised children , molar RBP : TTR ratio does not appear to be useful to assess VA status during infection ."
],
"offsets": [
[
0,
148
]
]
}
]
| [
{
"id": "split_0_train_2930_entity",
"type": "progene_text",
"text": [
"RBP"
],
"offsets": [
[
65,
68
]
],
"normalized": []
},
{
"id": "split_0_train_2931_entity",
"type": "progene_text",
"text": [
"TTR"
],
"offsets": [
[
71,
74
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1933 | split_0_train_1933 | [
{
"id": "split_0_train_1933_passage",
"type": "progene_text",
"text": [
"SPONSORSHIP :"
],
"offsets": [
[
0,
13
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1934 | split_0_train_1934 | [
{
"id": "split_0_train_1934_passage",
"type": "progene_text",
"text": [
"Our research was partially supported by a grant from the Fonds de la Recherche Scientifique et M�©dicale ( contract 3.4505.94 ) and the David and Alice Van Buuren Foundation ."
],
"offsets": [
[
0,
177
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1935 | split_0_train_1935 | [
{
"id": "split_0_train_1935_passage",
"type": "progene_text",
"text": [
"Novel role of Janus kinase 1 in the regulation of oncostatin M receptor surface expression ."
],
"offsets": [
[
0,
92
]
]
}
]
| [
{
"id": "split_0_train_2932_entity",
"type": "progene_text",
"text": [
"Janus kinase 1"
],
"offsets": [
[
14,
28
]
],
"normalized": []
},
{
"id": "split_0_train_2933_entity",
"type": "progene_text",
"text": [
"oncostatin M receptor"
],
"offsets": [
[
50,
71
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1936 | split_0_train_1936 | [
{
"id": "split_0_train_1936_passage",
"type": "progene_text",
"text": [
"The oncostatin M receptor ( OSMR ) is part of a heterodimeric receptor complex that mediates signal transduction of the pleiotropic cytokine OSM via a signaling pathway involving Janus kinases ( Jaks ) and transcription factors of the signal transducers and activators of transcription ( STAT ) family ."
],
"offsets": [
[
0,
303
]
]
}
]
| [
{
"id": "split_0_train_2934_entity",
"type": "progene_text",
"text": [
"oncostatin M receptor"
],
"offsets": [
[
4,
25
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],
"normalized": []
},
{
"id": "split_0_train_2935_entity",
"type": "progene_text",
"text": [
"OSMR"
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"offsets": [
[
28,
32
]
],
"normalized": []
},
{
"id": "split_0_train_2936_entity",
"type": "progene_text",
"text": [
"cytokine"
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"offsets": [
[
132,
140
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],
"normalized": []
},
{
"id": "split_0_train_2937_entity",
"type": "progene_text",
"text": [
"OSM"
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"offsets": [
[
141,
144
]
],
"normalized": []
},
{
"id": "split_0_train_2938_entity",
"type": "progene_text",
"text": [
"Janus kinases"
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"offsets": [
[
179,
192
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],
"normalized": []
},
{
"id": "split_0_train_2939_entity",
"type": "progene_text",
"text": [
"Jaks"
],
"offsets": [
[
195,
199
]
],
"normalized": []
},
{
"id": "split_0_train_2940_entity",
"type": "progene_text",
"text": [
"transcription factors"
],
"offsets": [
[
206,
227
]
],
"normalized": []
},
{
"id": "split_0_train_2941_entity",
"type": "progene_text",
"text": [
"signal transducers and activators of transcription ( STAT ) family"
],
"offsets": [
[
235,
301
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1937 | split_0_train_1937 | [
{
"id": "split_0_train_1937_passage",
"type": "progene_text",
"text": [
"Upon heterologous expression of the OSMR in several cell lines , we observed that its surface expression was significantly enhanced by coexpression of the Janus kinases Jak1 , Jak2 , and Tyk2 but not Jak3 ."
],
"offsets": [
[
0,
206
]
]
}
]
| [
{
"id": "split_0_train_2942_entity",
"type": "progene_text",
"text": [
"OSMR"
],
"offsets": [
[
36,
40
]
],
"normalized": []
},
{
"id": "split_0_train_2943_entity",
"type": "progene_text",
"text": [
"the Janus kinases"
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"offsets": [
[
151,
168
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],
"normalized": []
},
{
"id": "split_0_train_2944_entity",
"type": "progene_text",
"text": [
"Jak1"
],
"offsets": [
[
169,
173
]
],
"normalized": []
},
{
"id": "split_0_train_2945_entity",
"type": "progene_text",
"text": [
"Jak2"
],
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[
176,
180
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],
"normalized": []
},
{
"id": "split_0_train_2946_entity",
"type": "progene_text",
"text": [
"Tyk2"
],
"offsets": [
[
187,
191
]
],
"normalized": []
},
{
"id": "split_0_train_2947_entity",
"type": "progene_text",
"text": [
"Jak3"
],
"offsets": [
[
200,
204
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1938 | split_0_train_1938 | [
{
"id": "split_0_train_1938_passage",
"type": "progene_text",
"text": [
"Chimeric receptors consisting of the extracellular region of the interleukin-5 receptor beta chain and the transmembrane and intracellular part of the OSMR were similarly up - regulated on the plasma membrane when Jak1 was coexpressed ."
],
"offsets": [
[
0,
236
]
]
}
]
| [
{
"id": "split_0_train_2948_entity",
"type": "progene_text",
"text": [
"interleukin-5 receptor beta"
],
"offsets": [
[
65,
92
]
],
"normalized": []
},
{
"id": "split_0_train_2949_entity",
"type": "progene_text",
"text": [
"OSMR"
],
"offsets": [
[
151,
155
]
],
"normalized": []
},
{
"id": "split_0_train_2950_entity",
"type": "progene_text",
"text": [
"Jak1"
],
"offsets": [
[
214,
218
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1939 | split_0_train_1939 | [
{
"id": "split_0_train_1939_passage",
"type": "progene_text",
"text": [
"The overall expression level of these constructs did not change significantly , but Jak1 coexpression increased the amount of endoglycosidase H - resistant , fully processed OSMR chimeras ."
],
"offsets": [
[
0,
189
]
]
}
]
| [
{
"id": "split_0_train_2951_entity",
"type": "progene_text",
"text": [
"Jak1"
],
"offsets": [
[
84,
88
]
],
"normalized": []
},
{
"id": "split_0_train_2952_entity",
"type": "progene_text",
"text": [
"endoglycosidase H"
],
"offsets": [
[
126,
143
]
],
"normalized": []
},
{
"id": "split_0_train_2953_entity",
"type": "progene_text",
"text": [
"OSMR"
],
"offsets": [
[
174,
178
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1940 | split_0_train_1940 | [
{
"id": "split_0_train_1940_passage",
"type": "progene_text",
"text": [
"Using mutated receptor and Jak1 constructs , we were able to demonstrate that association of Jak1 with the membrane proximal region of the receptor , but not its kinase activity , is necessary for this effect ."
],
"offsets": [
[
0,
210
]
]
}
]
| [
{
"id": "split_0_train_2954_entity",
"type": "progene_text",
"text": [
"Jak1"
],
"offsets": [
[
27,
31
]
],
"normalized": []
},
{
"id": "split_0_train_2955_entity",
"type": "progene_text",
"text": [
"Jak1"
],
"offsets": [
[
93,
97
]
],
"normalized": []
},
{
"id": "split_0_train_2956_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
162,
168
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1941 | split_0_train_1941 | [
{
"id": "split_0_train_1941_passage",
"type": "progene_text",
"text": [
"Moreover , deletion of the OSMR box1 / 2 region also resulted in an improved surface expression indicating that this region may contain a signal preventing efficient receptor surface expression in the absence of associated Jaks ."
],
"offsets": [
[
0,
229
]
]
}
]
| [
{
"id": "split_0_train_2957_entity",
"type": "progene_text",
"text": [
"OSMR"
],
"offsets": [
[
27,
31
]
],
"normalized": []
},
{
"id": "split_0_train_2958_entity",
"type": "progene_text",
"text": [
"Jaks"
],
"offsets": [
[
223,
227
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1942 | split_0_train_1942 | [
{
"id": "split_0_train_1942_passage",
"type": "progene_text",
"text": [
"Finally we demonstrate that in Jak1 - deficient cells , the endogenous OSMR is significantly down - regulated , an effect that can be reversed by transient expression of Jak1 in these cells ."
],
"offsets": [
[
0,
191
]
]
}
]
| [
{
"id": "split_0_train_2959_entity",
"type": "progene_text",
"text": [
"Jak1"
],
"offsets": [
[
31,
35
]
],
"normalized": []
},
{
"id": "split_0_train_2960_entity",
"type": "progene_text",
"text": [
"OSMR"
],
"offsets": [
[
71,
75
]
],
"normalized": []
},
{
"id": "split_0_train_2961_entity",
"type": "progene_text",
"text": [
"Jak1"
],
"offsets": [
[
170,
174
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1943 | split_0_train_1943 | [
{
"id": "split_0_train_1943_passage",
"type": "progene_text",
"text": [
"A comparative study of E-cadherin and stromelysin-3 expression in de novo and ex adenoma carcinoma of the colorectum ."
],
"offsets": [
[
0,
118
]
]
}
]
| [
{
"id": "split_0_train_2962_entity",
"type": "progene_text",
"text": [
"E-cadherin"
],
"offsets": [
[
23,
33
]
],
"normalized": []
},
{
"id": "split_0_train_2963_entity",
"type": "progene_text",
"text": [
"stromelysin-3"
],
"offsets": [
[
38,
51
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1944 | split_0_train_1944 | [
{
"id": "split_0_train_1944_passage",
"type": "progene_text",
"text": [
"An apparent exception to the colorectal adenoma - carcinoma carcinogenetic pathway is the so - called \" de novo \" carcinoma which has no evidence of adenoma in its vicinity ."
],
"offsets": [
[
0,
174
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1945 | split_0_train_1945 | [
{
"id": "split_0_train_1945_passage",
"type": "progene_text",
"text": [
"Despite the fact that they are often quite small , these lesions appear to be more aggressive ( i.e. , greater likelihood of lymph - node metastases ) than carcinomas that clearly arise from surrounding adenomas exadenoma carcinoma ."
],
"offsets": [
[
0,
233
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1946 | split_0_train_1946 | [
{
"id": "split_0_train_1946_passage",
"type": "progene_text",
"text": [
"The purpose of the present comparative immunohistochemical study was to compare rates of cell adhesion molecule ( E-cadherin ) and protease [ stromelysin-3 ( ST-3 ) ] expression in groups of de novo ( n = 64 ) and ex adenoma ( n = 42 ) lesions in order to see whether their more aggressive behavior is associated with decreased cell adhesion and increased protease expression ."
],
"offsets": [
[
0,
377
]
]
}
]
| [
{
"id": "split_0_train_2964_entity",
"type": "progene_text",
"text": [
"cell adhesion molecule"
],
"offsets": [
[
89,
111
]
],
"normalized": []
},
{
"id": "split_0_train_2965_entity",
"type": "progene_text",
"text": [
"E-cadherin"
],
"offsets": [
[
114,
124
]
],
"normalized": []
},
{
"id": "split_0_train_2966_entity",
"type": "progene_text",
"text": [
"protease"
],
"offsets": [
[
131,
139
]
],
"normalized": []
},
{
"id": "split_0_train_2967_entity",
"type": "progene_text",
"text": [
"stromelysin-3"
],
"offsets": [
[
142,
155
]
],
"normalized": []
},
{
"id": "split_0_train_2968_entity",
"type": "progene_text",
"text": [
"ST-3"
],
"offsets": [
[
158,
162
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1947 | split_0_train_1947 | [
{
"id": "split_0_train_1947_passage",
"type": "progene_text",
"text": [
"The rates of extensive ST-3 expression and decreased E-cadherin expression were significantly higher in the de novo group ( P = 0.014 and 0.005 , respectively ) ."
],
"offsets": [
[
0,
162
]
]
}
]
| [
{
"id": "split_0_train_2969_entity",
"type": "progene_text",
"text": [
"ST-3"
],
"offsets": [
[
23,
27
]
],
"normalized": []
},
{
"id": "split_0_train_2970_entity",
"type": "progene_text",
"text": [
"E-cadherin"
],
"offsets": [
[
53,
63
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1948 | split_0_train_1948 | [
{
"id": "split_0_train_1948_passage",
"type": "progene_text",
"text": [
"Histopathologically , the de novo group also had a significantly higher percentage of cases with an infiltrative invasion pattern ."
],
"offsets": [
[
0,
131
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1949 | split_0_train_1949 | [
{
"id": "split_0_train_1949_passage",
"type": "progene_text",
"text": [
"These differences highlight the more aggressive phenotype of the de novo colorectal carcinoma and fit with their greater invasive potential ."
],
"offsets": [
[
0,
141
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1950 | split_0_train_1950 | [
{
"id": "split_0_train_1950_passage",
"type": "progene_text",
"text": [
"Proteomic patterns of nipple aspirate fluids obtained by SELDI-TOF : potential for new biomarkers to aid in the diagnosis of breast cancer ."
],
"offsets": [
[
0,
140
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1951 | split_0_train_1951 | [
{
"id": "split_0_train_1951_passage",
"type": "progene_text",
"text": [
"Nipple aspirate fluid ( NAF ) has been used for many years as a potential non - invasive method to identify markers for breast cancer risk or early detection ."
],
"offsets": [
[
0,
159
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1952 | split_0_train_1952 | [
{
"id": "split_0_train_1952_passage",
"type": "progene_text",
"text": [
"Because individual markers have not been optimal , we are exploring the use of surface enhanced laser desorption and ionization time of flight ( SELDI-TOF ) mass spectrometry to identify patterns of proteins that might define a proteomic signature for breast cancer ."
],
"offsets": [
[
0,
267
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1953 | split_0_train_1953 | [
{
"id": "split_0_train_1953_passage",
"type": "progene_text",
"text": [
"SELDI-TOF was used to analyze a study set of NAF samples that included 12 women with breast cancer and 15 healthy controls ( the latter included three women with an abnormal mammogram but subsequent normal biopsy ) ."
],
"offsets": [
[
0,
216
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1954 | split_0_train_1954 | [
{
"id": "split_0_train_1954_passage",
"type": "progene_text",
"text": [
"In this preliminary report , we present data showing that SELDI analysis of NAF is rapid , reproducible , and capable of identifying protein signatures that appear to differentiate NAF samples from breast cancer patients and healthy controls , including those with an abnormal mammogram who were later proven to be biopsy normal ."
],
"offsets": [
[
0,
330
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1955 | split_0_train_1955 | [
{
"id": "split_0_train_1955_passage",
"type": "progene_text",
"text": [
"Interleukin-10 levels in seminal plasma : implications for chronic prostatitis - chronic pelvic pain syndrome ."
],
"offsets": [
[
0,
111
]
]
}
]
| [
{
"id": "split_0_train_2971_entity",
"type": "progene_text",
"text": [
"Interleukin-10"
],
"offsets": [
[
0,
14
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1956 | split_0_train_1956 | [
{
"id": "split_0_train_1956_passage",
"type": "progene_text",
"text": [
"PURPOSE :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1957 | split_0_train_1957 | [
{
"id": "split_0_train_1957_passage",
"type": "progene_text",
"text": [
"Chronic prostatitis - chronic pelvic pain syndrome is a disease of unknown pathogenesis ."
],
"offsets": [
[
0,
89
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1958 | split_0_train_1958 | [
{
"id": "split_0_train_1958_passage",
"type": "progene_text",
"text": [
"We investigated whether the chronic inflammation and pain experienced by patients may be caused by an imbalance of proinflammatory versus anti - inflammatory cytokines within the prostate , namely interleukin ( IL ) - 8 , interferon - gamma and IL-2 versus IL-10 ."
],
"offsets": [
[
0,
264
]
]
}
]
| [
{
"id": "split_0_train_2972_entity",
"type": "progene_text",
"text": [
"cytokines"
],
"offsets": [
[
158,
167
]
],
"normalized": []
},
{
"id": "split_0_train_2973_entity",
"type": "progene_text",
"text": [
"interleukin ( IL ) - 8"
],
"offsets": [
[
197,
219
]
],
"normalized": []
},
{
"id": "split_0_train_2974_entity",
"type": "progene_text",
"text": [
"interferon - gamma"
],
"offsets": [
[
222,
240
]
],
"normalized": []
},
{
"id": "split_0_train_2975_entity",
"type": "progene_text",
"text": [
"IL-2"
],
"offsets": [
[
245,
249
]
],
"normalized": []
},
{
"id": "split_0_train_2976_entity",
"type": "progene_text",
"text": [
"IL-10"
],
"offsets": [
[
257,
262
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1959 | split_0_train_1959 | [
{
"id": "split_0_train_1959_passage",
"type": "progene_text",
"text": [
"We measured these inflammatory cytokines in seminal plasma as a reflection of the prostate environment ."
],
"offsets": [
[
0,
104
]
]
}
]
| [
{
"id": "split_0_train_2977_entity",
"type": "progene_text",
"text": [
"cytokines"
],
"offsets": [
[
31,
40
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1960 | split_0_train_1960 | [
{
"id": "split_0_train_1960_passage",
"type": "progene_text",
"text": [
"MATERIALS AND METHODS :"
],
"offsets": [
[
0,
23
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1961 | split_0_train_1961 | [
{
"id": "split_0_train_1961_passage",
"type": "progene_text",
"text": [
"We measured levels of IL-8 , interferon-gamma , IL-2 and IL-10 in the seminal plasma of 31 patients with chronic prostatitis - chronic pelvic pain syndrome and 14 controls using enzyme - linked immunosorbent assay ."
],
"offsets": [
[
0,
215
]
]
}
]
| [
{
"id": "split_0_train_2978_entity",
"type": "progene_text",
"text": [
"IL-8"
],
"offsets": [
[
22,
26
]
],
"normalized": []
},
{
"id": "split_0_train_2979_entity",
"type": "progene_text",
"text": [
"interferon-gamma"
],
"offsets": [
[
29,
45
]
],
"normalized": []
},
{
"id": "split_0_train_2980_entity",
"type": "progene_text",
"text": [
"IL-2"
],
"offsets": [
[
48,
52
]
],
"normalized": []
},
{
"id": "split_0_train_2981_entity",
"type": "progene_text",
"text": [
"IL-10"
],
"offsets": [
[
57,
62
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1962 | split_0_train_1962 | [
{
"id": "split_0_train_1962_passage",
"type": "progene_text",
"text": [
"Results were correlated with health related quality of life , as measured by the Multidimensional Pain Inventory , McGill pain questionnaire and International Prostate Symptom Score ."
],
"offsets": [
[
0,
183
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1963 | split_0_train_1963 | [
{
"id": "split_0_train_1963_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1964 | split_0_train_1964 | [
{
"id": "split_0_train_1964_passage",
"type": "progene_text",
"text": [
"The cytokines analyzed were detectable in the seminal plasma of patients with chronic prostatitis - chronic pelvic pain syndrome and controls ."
],
"offsets": [
[
0,
143
]
]
}
]
| [
{
"id": "split_0_train_2982_entity",
"type": "progene_text",
"text": [
"cytokines"
],
"offsets": [
[
4,
13
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1965 | split_0_train_1965 | [
{
"id": "split_0_train_1965_passage",
"type": "progene_text",
"text": [
"Interferon - gamma , IL-2 and IL-10 levels were statistically greater in patients ."
],
"offsets": [
[
0,
83
]
]
}
]
| [
{
"id": "split_0_train_2983_entity",
"type": "progene_text",
"text": [
"Interferon - gamma"
],
"offsets": [
[
0,
18
]
],
"normalized": []
},
{
"id": "split_0_train_2984_entity",
"type": "progene_text",
"text": [
"IL-2"
],
"offsets": [
[
21,
25
]
],
"normalized": []
},
{
"id": "split_0_train_2985_entity",
"type": "progene_text",
"text": [
"IL-10"
],
"offsets": [
[
30,
35
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1966 | split_0_train_1966 | [
{
"id": "split_0_train_1966_passage",
"type": "progene_text",
"text": [
"Furthermore , IL-10 levels correlated directly with measures of life interference ( r = 0.52 , p < 0.01 ) and pain severity ( r = 0.53 , p < 0 0.01 ) , and inversely with spousal support ( r = - 0.39 , p < 0.04 ) ."
],
"offsets": [
[
0,
214
]
]
}
]
| [
{
"id": "split_0_train_2986_entity",
"type": "progene_text",
"text": [
"IL-10"
],
"offsets": [
[
14,
19
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1967 | split_0_train_1967 | [
{
"id": "split_0_train_1967_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1968 | split_0_train_1968 | [
{
"id": "split_0_train_1968_passage",
"type": "progene_text",
"text": [
"Our study suggests that IL-10 may have a role in the pain symptoms experienced by patients with chronic prostatitis - chronic pelvic pain syndrome ."
],
"offsets": [
[
0,
148
]
]
}
]
| [
{
"id": "split_0_train_2987_entity",
"type": "progene_text",
"text": [
"IL-10"
],
"offsets": [
[
24,
29
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1969 | split_0_train_1969 | [
{
"id": "split_0_train_1969_passage",
"type": "progene_text",
"text": [
"Present data concerning the renin - angiotensin system of extrarenal origin ."
],
"offsets": [
[
0,
77
]
]
}
]
| [
{
"id": "split_0_train_2988_entity",
"type": "progene_text",
"text": [
"renin"
],
"offsets": [
[
28,
33
]
],
"normalized": []
},
{
"id": "split_0_train_2989_entity",
"type": "progene_text",
"text": [
"angiotensin"
],
"offsets": [
[
36,
47
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1970 | split_0_train_1970 | [
{
"id": "split_0_train_1970_passage",
"type": "progene_text",
"text": [
"After a brief historical incursion regarding RAS of renal origin , we present the main extrarenal angiotensin - forming enzymes , starting with isorenin , tonin , D and G cathepsin and ending with the conversion enzyme and chymase ."
],
"offsets": [
[
0,
232
]
]
}
]
| [
{
"id": "split_0_train_2990_entity",
"type": "progene_text",
"text": [
"angiotensin"
],
"offsets": [
[
98,
109
]
],
"normalized": []
},
{
"id": "split_0_train_2991_entity",
"type": "progene_text",
"text": [
"isorenin"
],
"offsets": [
[
144,
152
]
],
"normalized": []
},
{
"id": "split_0_train_2992_entity",
"type": "progene_text",
"text": [
"tonin"
],
"offsets": [
[
155,
160
]
],
"normalized": []
},
{
"id": "split_0_train_2993_entity",
"type": "progene_text",
"text": [
"D and G cathepsin"
],
"offsets": [
[
163,
180
]
],
"normalized": []
},
{
"id": "split_0_train_2994_entity",
"type": "progene_text",
"text": [
"conversion enzyme"
],
"offsets": [
[
201,
218
]
],
"normalized": []
},
{
"id": "split_0_train_2995_entity",
"type": "progene_text",
"text": [
"chymase"
],
"offsets": [
[
223,
230
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1971 | split_0_train_1971 | [
{
"id": "split_0_train_1971_passage",
"type": "progene_text",
"text": [
"This is followed by a short presentation of data concerning tissue RAS in the heart and vessels , brain and neurocranial accessory glands , cortico - suprarenal and gonadal glandular territory ."
],
"offsets": [
[
0,
194
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1972 | split_0_train_1972 | [
{
"id": "split_0_train_1972_passage",
"type": "progene_text",
"text": [
"In the end we refer to the relations between circulating RAS of renal origin and the extrarenal RAS specific to tissue underlying the fact that the two RAS components cooperate and constitute a unitary hormonal system , regulating the major functions of the organism and maintaining the main homeostatic equilibria ."
],
"offsets": [
[
0,
316
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1973 | split_0_train_1973 | [
{
"id": "split_0_train_1973_passage",
"type": "progene_text",
"text": [
"While the circulating RAS of renal origin is acutely activated to contribute to the accomplishment of short term homeostatic reactions , tissue RAS , in paracrine or autocrine ways , exerts local - regional adaptive actions of long duration ."
],
"offsets": [
[
0,
242
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1974 | split_0_train_1974 | [
{
"id": "split_0_train_1974_passage",
"type": "progene_text",
"text": [
"Revitalizing the General Practice Research Database : plans , challenges , and opportunities ."
],
"offsets": [
[
0,
94
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1975 | split_0_train_1975 | [
{
"id": "split_0_train_1975_passage",
"type": "progene_text",
"text": [
"The General Practice Research Database ( GPRD ) is the world 's largest computerized database of anonymized longitudinal patient records from general practice and is a unique public health research tool ."
],
"offsets": [
[
0,
204
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1976 | split_0_train_1976 | [
{
"id": "split_0_train_1976_passage",
"type": "progene_text",
"text": [
"Several issues have threatened the viability of the database in recent years ; in April 1999 responsibility for its management and financial control was transferred to the UK Medicines Control Agency ( MCA ) ."
],
"offsets": [
[
0,
209
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1977 | split_0_train_1977 | [
{
"id": "split_0_train_1977_passage",
"type": "progene_text",
"text": [
"This presentation outlines the MCA 's plans and future vision for the GPRD ."
],
"offsets": [
[
0,
76
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1978 | split_0_train_1978 | [
{
"id": "split_0_train_1978_passage",
"type": "progene_text",
"text": [
"A major marker for normal tension glaucoma : association with polymorphisms in the OPA1 gene ."
],
"offsets": [
[
0,
94
]
]
}
]
| [
{
"id": "split_0_train_2996_entity",
"type": "progene_text",
"text": [
"OPA1"
],
"offsets": [
[
83,
87
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1979 | split_0_train_1979 | [
{
"id": "split_0_train_1979_passage",
"type": "progene_text",
"text": [
"Normal tension glaucoma ( NTG ) is a major form of glaucoma , associated with intraocular pressures that are within the statistically normal range of the population ."
],
"offsets": [
[
0,
166
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1980 | split_0_train_1980 | [
{
"id": "split_0_train_1980_passage",
"type": "progene_text",
"text": [
"OPA1 , the gene responsible for autosomal dominant optic atrophy represents an excellent candidate gene for NTG , as the clinical phenotypes are similar and OPA1 is expressed in the retina and optic nerve ."
],
"offsets": [
[
0,
206
]
]
}
]
| [
{
"id": "split_0_train_2997_entity",
"type": "progene_text",
"text": [
"OPA1"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_2998_entity",
"type": "progene_text",
"text": [
"OPA1"
],
"offsets": [
[
157,
161
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1981 | split_0_train_1981 | [
{
"id": "split_0_train_1981_passage",
"type": "progene_text",
"text": [
"Eighty - three well - characterized NTG patients were screened for mutations in OPA1 by heteroduplex analysis and bi - directional sequencing ."
],
"offsets": [
[
0,
143
]
]
}
]
| [
{
"id": "split_0_train_2999_entity",
"type": "progene_text",
"text": [
"OPA1"
],
"offsets": [
[
80,
84
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1982 | split_0_train_1982 | [
{
"id": "split_0_train_1982_passage",
"type": "progene_text",
"text": [
"Sequences found to be altered in NTG subjects were examined for variations in 100 population controls ."
],
"offsets": [
[
0,
103
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1983 | split_0_train_1983 | [
{
"id": "split_0_train_1983_passage",
"type": "progene_text",
"text": [
"A second cohort of 80 NTG patients and 86 population controls was subsequently screened to determine whether the initial findings could be replicated ."
],
"offsets": [
[
0,
151
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1984 | split_0_train_1984 | [
{
"id": "split_0_train_1984_passage",
"type": "progene_text",
"text": [
"A single nucleotide polymorphism ( SNP ) on intervening sequence ( IVS ) 8 ( IVS8 + 4 C / T ) was found to be strongly associated with the occurrence of NTG in both cohorts ( chi(2) = 7.97 , P = 0.005 in the first cohort , chi(2) = 9.93 , P = 0.002 in the second cohort ; odds ratio 3.1 ( 95 % CI : 1.8 - 5.6 ) . A second SNP ( IVS8 + 32 T / C ) appeared to be associated with disease in the first cohort ( chi(2) = 4.71 , P = 0.030 ) , but this finding could not be replicated in the second cohort ."
],
"offsets": [
[
0,
500
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1985 | split_0_train_1985 | [
{
"id": "split_0_train_1985_passage",
"type": "progene_text",
"text": [
"In the combined cohort , the compound at - risk genotype IVS8 + 4 C / T , + 32 T/C was strongly associated with the occurrence of NTG ( chi(2) = 22.04 , P = 0.00001 after correcting for testing four genotypes ) ."
],
"offsets": [
[
0,
212
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1986 | split_0_train_1986 | [
{
"id": "split_0_train_1986_passage",
"type": "progene_text",
"text": [
"These results indicate that polymorphisms in the OPA1 gene are associated with NTG and may be a marker for the disease ."
],
"offsets": [
[
0,
120
]
]
}
]
| [
{
"id": "split_0_train_3000_entity",
"type": "progene_text",
"text": [
"OPA1"
],
"offsets": [
[
49,
53
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1987 | split_0_train_1987 | [
{
"id": "split_0_train_1987_passage",
"type": "progene_text",
"text": [
"Development of a rapid and sensitive high - performance liquid chromatographic method to determine CYP2D6 phenotype in human liver microsomes ."
],
"offsets": [
[
0,
143
]
]
}
]
| [
{
"id": "split_0_train_3001_entity",
"type": "progene_text",
"text": [
"CYP2D6"
],
"offsets": [
[
99,
105
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1988 | split_0_train_1988 | [
{
"id": "split_0_train_1988_passage",
"type": "progene_text",
"text": [
"Dextromethorphan is a probe substrate to determine CYP2D6 phenotype ."
],
"offsets": [
[
0,
69
]
]
}
]
| [
{
"id": "split_0_train_3002_entity",
"type": "progene_text",
"text": [
"CYP2D6"
],
"offsets": [
[
51,
57
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1989 | split_0_train_1989 | [
{
"id": "split_0_train_1989_passage",
"type": "progene_text",
"text": [
"The conversion of dextromethorphan to dextrorphan by CYP2D6 accounts for approximately 60 % of total metabolism ."
],
"offsets": [
[
0,
113
]
]
}
]
| [
{
"id": "split_0_train_3003_entity",
"type": "progene_text",
"text": [
"CYP2D6"
],
"offsets": [
[
53,
59
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1990 | split_0_train_1990 | [
{
"id": "split_0_train_1990_passage",
"type": "progene_text",
"text": [
"Most analytical methods utilize complicated labor - and time - intensive sample processing methods with several liquid - liquid extraction ( LLE ) steps ."
],
"offsets": [
[
0,
154
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1991 | split_0_train_1991 | [
{
"id": "split_0_train_1991_passage",
"type": "progene_text",
"text": [
"Our goal was to develop a non - LLE based rapid and sensitive HPLC method , to measure dextromethorphan metabolism in human liver microsomes ."
],
"offsets": [
[
0,
142
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1992 | split_0_train_1992 | [
{
"id": "split_0_train_1992_passage",
"type": "progene_text",
"text": [
"A solid - phase filtration based reverse - phase HPLC method with fluorescence detection was developed and validated ."
],
"offsets": [
[
0,
118
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1993 | split_0_train_1993 | [
{
"id": "split_0_train_1993_passage",
"type": "progene_text",
"text": [
"Human liver ( n = 6 ) microsomal incubations were carried out with dextromethorphan , under optimum conditions ."
],
"offsets": [
[
0,
112
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1994 | split_0_train_1994 | [
{
"id": "split_0_train_1994_passage",
"type": "progene_text",
"text": [
"The analytes were separated by one - step centrifugal filtration with Nanosep separation units ."
],
"offsets": [
[
0,
96
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1995 | split_0_train_1995 | [
{
"id": "split_0_train_1995_passage",
"type": "progene_text",
"text": [
"The filtrate was injected ( 50 microL ) into a Waters Alliance 2690 HPLC system ."
],
"offsets": [
[
0,
81
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1996 | split_0_train_1996 | [
{
"id": "split_0_train_1996_passage",
"type": "progene_text",
"text": [
"Metabolic incubations were also conducted to determine levels using LLE for comparisons ."
],
"offsets": [
[
0,
89
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1997 | split_0_train_1997 | [
{
"id": "split_0_train_1997_passage",
"type": "progene_text",
"text": [
"The Nanosep separation step reduced the extraction time from 3h to 40 min ."
],
"offsets": [
[
0,
75
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1998 | split_0_train_1998 | [
{
"id": "split_0_train_1998_passage",
"type": "progene_text",
"text": [
"The limit of quantitation was 23.8 nM ( 9.7 ng / mL ) , recovery was approximately 98 % , the mean precision values were < 10 % RSD for the controls ( 80 , 320 and 640 nM ) and mean percentage error was < 5 % ."
],
"offsets": [
[
0,
210
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1999 | split_0_train_1999 | [
{
"id": "split_0_train_1999_passage",
"type": "progene_text",
"text": [
"Michaelis - Menten parameters were determined to distinguish CYP2D6 phenotypes ."
],
"offsets": [
[
0,
80
]
]
}
]
| [
{
"id": "split_0_train_3004_entity",
"type": "progene_text",
"text": [
"CYP2D6"
],
"offsets": [
[
61,
67
]
],
"normalized": []
}
]
| []
| []
| []
|
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