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split_0_train_2000 | split_0_train_2000 | [
{
"id": "split_0_train_2000_passage",
"type": "progene_text",
"text": [
"A rapid and sensitive HPLC method is reported , which may be suitable for automation and allows phenotyping of human liver microsomes ."
],
"offsets": [
[
0,
135
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2001 | split_0_train_2001 | [
{
"id": "split_0_train_2001_passage",
"type": "progene_text",
"text": [
"PLIF , a novel human ferritin subunit from placenta with immunosuppressive activity ."
],
"offsets": [
[
0,
85
]
]
}
]
| [
{
"id": "split_0_train_3005_entity",
"type": "progene_text",
"text": [
"PLIF"
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"offsets": [
[
0,
4
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{
"id": "split_0_train_3006_entity",
"type": "progene_text",
"text": [
"ferritin"
],
"offsets": [
[
21,
29
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2002 | split_0_train_2002 | [
{
"id": "split_0_train_2002_passage",
"type": "progene_text",
"text": [
"Ferritin is a ubiquitous iron storage protein existing in multiple isoforms composed of 24 heavy and light chain subunits ."
],
"offsets": [
[
0,
123
]
]
}
]
| [
{
"id": "split_0_train_3007_entity",
"type": "progene_text",
"text": [
"Ferritin"
],
"offsets": [
[
0,
8
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2003 | split_0_train_2003 | [
{
"id": "split_0_train_2003_passage",
"type": "progene_text",
"text": [
"We describe here a third ferritin - related subunit cloned from human placenta cDNA library and named PLIF ( placental immunomodulatory ferritin ) ."
],
"offsets": [
[
0,
148
]
]
}
]
| [
{
"id": "split_0_train_3008_entity",
"type": "progene_text",
"text": [
"ferritin"
],
"offsets": [
[
25,
33
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],
"normalized": []
},
{
"id": "split_0_train_3009_entity",
"type": "progene_text",
"text": [
"PLIF"
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[
102,
106
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],
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},
{
"id": "split_0_train_3010_entity",
"type": "progene_text",
"text": [
"placental immunomodulatory ferritin"
],
"offsets": [
[
109,
144
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2004 | split_0_train_2004 | [
{
"id": "split_0_train_2004_passage",
"type": "progene_text",
"text": [
"The PLIF coding region is composed of ferritin heavy chain ( FTH ) sequence lacking the 65 C - terminal amino acids , which are substituted with a novel 48 amino acid domain ( C48 ) ."
],
"offsets": [
[
0,
183
]
]
}
]
| [
{
"id": "split_0_train_3011_entity",
"type": "progene_text",
"text": [
"PLIF"
],
"offsets": [
[
4,
8
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],
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},
{
"id": "split_0_train_3012_entity",
"type": "progene_text",
"text": [
"ferritin heavy chain"
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[
38,
58
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],
"normalized": []
},
{
"id": "split_0_train_3013_entity",
"type": "progene_text",
"text": [
"FTH"
],
"offsets": [
[
61,
64
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2005 | split_0_train_2005 | [
{
"id": "split_0_train_2005_passage",
"type": "progene_text",
"text": [
"In contrast to FTH , PLIF mRNA does not include the iron response element in the 5' - untranslated region , suggesting that PLIF synthesis is not regulated by iron ."
],
"offsets": [
[
0,
165
]
]
}
]
| [
{
"id": "split_0_train_3014_entity",
"type": "progene_text",
"text": [
"FTH"
],
"offsets": [
[
15,
18
]
],
"normalized": []
},
{
"id": "split_0_train_3015_entity",
"type": "progene_text",
"text": [
"PLIF"
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"offsets": [
[
21,
25
]
],
"normalized": []
},
{
"id": "split_0_train_3016_entity",
"type": "progene_text",
"text": [
"PLIF"
],
"offsets": [
[
124,
128
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2006 | split_0_train_2006 | [
{
"id": "split_0_train_2006_passage",
"type": "progene_text",
"text": [
"The linkage between the FTH and C48 domains created a restriction site for EcoRI ."
],
"offsets": [
[
0,
82
]
]
}
]
| [
{
"id": "split_0_train_3017_entity",
"type": "progene_text",
"text": [
"FTH"
],
"offsets": [
[
24,
27
]
],
"normalized": []
},
{
"id": "split_0_train_3018_entity",
"type": "progene_text",
"text": [
"EcoRI"
],
"offsets": [
[
75,
80
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2007 | split_0_train_2007 | [
{
"id": "split_0_train_2007_passage",
"type": "progene_text",
"text": [
"PLIF protein was found to localize in syncytiotrophoblasts of placentas ( 8 weeks of gestation ) at the fetal - maternal interface ."
],
"offsets": [
[
0,
132
]
]
}
]
| [
{
"id": "split_0_train_3019_entity",
"type": "progene_text",
"text": [
"PLIF"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2008 | split_0_train_2008 | [
{
"id": "split_0_train_2008_passage",
"type": "progene_text",
"text": [
"Increased levels of PLIF transcript and protein were also detected in the breast carcinoma cell lines T47D and MCF-7 but not in the benign corresponding cell line HBL-100 ."
],
"offsets": [
[
0,
172
]
]
}
]
| [
{
"id": "split_0_train_3020_entity",
"type": "progene_text",
"text": [
"PLIF"
],
"offsets": [
[
20,
24
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2009 | split_0_train_2009 | [
{
"id": "split_0_train_2009_passage",
"type": "progene_text",
"text": [
"In vitro , PLIF was shown to down - modulate mixed lymphocyte reactions and to inhibit the proliferation of peripheral blood mononuclear cells stimulated with OKT3 ."
],
"offsets": [
[
0,
165
]
]
}
]
| [
{
"id": "split_0_train_3021_entity",
"type": "progene_text",
"text": [
"PLIF"
],
"offsets": [
[
11,
15
]
],
"normalized": []
},
{
"id": "split_0_train_3022_entity",
"type": "progene_text",
"text": [
"OKT3"
],
"offsets": [
[
159,
163
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2010 | split_0_train_2010 | [
{
"id": "split_0_train_2010_passage",
"type": "progene_text",
"text": [
"The accumulated data indicate that PLIF is an embryonic immune factor involved in down - modulating the maternal immune recognition of the embryo toward anergy ."
],
"offsets": [
[
0,
161
]
]
}
]
| [
{
"id": "split_0_train_3023_entity",
"type": "progene_text",
"text": [
"PLIF"
],
"offsets": [
[
35,
39
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2011 | split_0_train_2011 | [
{
"id": "split_0_train_2011_passage",
"type": "progene_text",
"text": [
"This mechanism may have been adapted by breast cancer cells over expressing PLIF ."
],
"offsets": [
[
0,
82
]
]
}
]
| [
{
"id": "split_0_train_3024_entity",
"type": "progene_text",
"text": [
"PLIF"
],
"offsets": [
[
76,
80
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2012 | split_0_train_2012 | [
{
"id": "split_0_train_2012_passage",
"type": "progene_text",
"text": [
"Characterization of basolateral K+ channels underlying anion secretion in the human airway cell line Calu - 3 ."
],
"offsets": [
[
0,
111
]
]
}
]
| [
{
"id": "split_0_train_3025_entity",
"type": "progene_text",
"text": [
"K+ channels"
],
"offsets": [
[
32,
43
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2013 | split_0_train_2013 | [
{
"id": "split_0_train_2013_passage",
"type": "progene_text",
"text": [
"Transepithelial anion secretion in many tissues depends upon the activity of basolateral channels ."
],
"offsets": [
[
0,
99
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2014 | split_0_train_2014 | [
{
"id": "split_0_train_2014_passage",
"type": "progene_text",
"text": [
"Using monolayers of the Calu-3 cell line , a human submucosal serous cell model mounted in an Ussing chamber apparatus , we investigated the nature of the K + channels involved in basal , cAMP - and Ca2 + - stimulated anion secretion , as reflected by the transepithelial short circuit current ( I ( sc ) ) ."
],
"offsets": [
[
0,
308
]
]
}
]
| [
{
"id": "split_0_train_3026_entity",
"type": "progene_text",
"text": [
"K + channels"
],
"offsets": [
[
155,
167
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2015 | split_0_train_2015 | [
{
"id": "split_0_train_2015_passage",
"type": "progene_text",
"text": [
"The non - specific K+ channel inhibitor Ba2 + inhibited the basal I ( sc ) by either 77 or 16 % when applied directly to the basolateral or apical membranes , respectively , indicating that a basolateral K + conductance is required for maintenance of basal anion secretion ."
],
"offsets": [
[
0,
274
]
]
}
]
| [
{
"id": "split_0_train_3027_entity",
"type": "progene_text",
"text": [
"K+ channel"
],
"offsets": [
[
19,
29
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2016 | split_0_train_2016 | [
{
"id": "split_0_train_2016_passage",
"type": "progene_text",
"text": [
"Using the K+ channel blockers clofilium and clotrimazole , we found basal I ( sc ) to be sensitive to clofilium , with a small clotrimazole - sensitive component ."
],
"offsets": [
[
0,
163
]
]
}
]
| [
{
"id": "split_0_train_3028_entity",
"type": "progene_text",
"text": [
"K+ channel"
],
"offsets": [
[
10,
20
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2017 | split_0_train_2017 | [
{
"id": "split_0_train_2017_passage",
"type": "progene_text",
"text": [
"By stimulating the cAMP and Ca2+ pathways , we determined that cAMP - stimulated anion secretion was almost entirely abolished by clofilium , but insensitive to clotrimazole ."
],
"offsets": [
[
0,
175
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2018 | split_0_train_2018 | [
{
"id": "split_0_train_2018_passage",
"type": "progene_text",
"text": [
"In contrast , the Ca2+ - stimulated response was sensitive to both clofilium and clotrimazole ."
],
"offsets": [
[
0,
95
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2019 | split_0_train_2019 | [
{
"id": "split_0_train_2019_passage",
"type": "progene_text",
"text": [
"Thus , pharmacologically distinct basolateral K + channels are differentially involved in the control of anion secretion under different conditions ."
],
"offsets": [
[
0,
149
]
]
}
]
| [
{
"id": "split_0_train_3029_entity",
"type": "progene_text",
"text": [
"K + channels"
],
"offsets": [
[
46,
58
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2020 | split_0_train_2020 | [
{
"id": "split_0_train_2020_passage",
"type": "progene_text",
"text": [
"Isolation of the basolateral K + conductance in permeabilized monolayers revealed a small basal and forskolin - stimulated I ( sc ) ."
],
"offsets": [
[
0,
133
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2021 | split_0_train_2021 | [
{
"id": "split_0_train_2021_passage",
"type": "progene_text",
"text": [
"Finally , using the reverse transcriptase - polymerase chain reaction , we found that Calu-3 cells express the K + channel genes KCNN4 and KCNQ1 and the subunits KCNE2 and KCNE3 ."
],
"offsets": [
[
0,
179
]
]
}
]
| [
{
"id": "split_0_train_3030_entity",
"type": "progene_text",
"text": [
"K + channel"
],
"offsets": [
[
111,
122
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],
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},
{
"id": "split_0_train_3031_entity",
"type": "progene_text",
"text": [
"KCNN4"
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"offsets": [
[
129,
134
]
],
"normalized": []
},
{
"id": "split_0_train_3032_entity",
"type": "progene_text",
"text": [
"KCNQ1"
],
"offsets": [
[
139,
144
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],
"normalized": []
},
{
"id": "split_0_train_3033_entity",
"type": "progene_text",
"text": [
"KCNE2"
],
"offsets": [
[
162,
167
]
],
"normalized": []
},
{
"id": "split_0_train_3034_entity",
"type": "progene_text",
"text": [
"KCNE3"
],
"offsets": [
[
172,
177
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2022 | split_0_train_2022 | [
{
"id": "split_0_train_2022_passage",
"type": "progene_text",
"text": [
"We conclude that while KCNN4 contributes to Ca2+ - activated anion secretion by Calu-3 cells , basal and cAMP - activated secretion are more critically dependent on other K + channel types , possibly involving one or more class of KCNQ1 - containing channel complexes ."
],
"offsets": [
[
0,
269
]
]
}
]
| [
{
"id": "split_0_train_3035_entity",
"type": "progene_text",
"text": [
"KCNN4"
],
"offsets": [
[
23,
28
]
],
"normalized": []
},
{
"id": "split_0_train_3036_entity",
"type": "progene_text",
"text": [
"K + channel"
],
"offsets": [
[
171,
182
]
],
"normalized": []
},
{
"id": "split_0_train_3037_entity",
"type": "progene_text",
"text": [
"KCNQ1"
],
"offsets": [
[
231,
236
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2023 | split_0_train_2023 | [
{
"id": "split_0_train_2023_passage",
"type": "progene_text",
"text": [
"CSF total tau , Abeta42 and phosphorylated tau protein as biomarkers for Alzheimer 's disease ."
],
"offsets": [
[
0,
95
]
]
}
]
| [
{
"id": "split_0_train_3038_entity",
"type": "progene_text",
"text": [
"tau"
],
"offsets": [
[
10,
13
]
],
"normalized": []
},
{
"id": "split_0_train_3039_entity",
"type": "progene_text",
"text": [
"Abeta42"
],
"offsets": [
[
16,
23
]
],
"normalized": []
},
{
"id": "split_0_train_3040_entity",
"type": "progene_text",
"text": [
"tau"
],
"offsets": [
[
43,
46
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2024 | split_0_train_2024 | [
{
"id": "split_0_train_2024_passage",
"type": "progene_text",
"text": [
"With the arrival of effective symptomatic treatments and the promise of drugs that may delay progression , we now need to identify Alzheimer 's disease ( AD ) at an early stage of the disease ."
],
"offsets": [
[
0,
193
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2025 | split_0_train_2025 | [
{
"id": "split_0_train_2025_passage",
"type": "progene_text",
"text": [
"To diagnose AD earlier and more accurately , attention has been directed toward peripheral biochemical markers ."
],
"offsets": [
[
0,
112
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2026 | split_0_train_2026 | [
{
"id": "split_0_train_2026_passage",
"type": "progene_text",
"text": [
"This article reviews promising potential cerebrospinal fluid ( CSF ) biomarkers for AD focussing on their role in clinical diagnosis ."
],
"offsets": [
[
0,
134
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2027 | split_0_train_2027 | [
{
"id": "split_0_train_2027_passage",
"type": "progene_text",
"text": [
"In particular , two biochemical markers , CSF total tau ( t - tau ) protein and the 42 amino acid form of beta-amyloid ( Abeta42 ) , perform satisfactorily enough to achieve a role in the clinical diagnostic settings of patients with dementia together with the cumulative information from basic clinical work - up , genetic screening , and brain imaging ."
],
"offsets": [
[
0,
355
]
]
}
]
| [
{
"id": "split_0_train_3041_entity",
"type": "progene_text",
"text": [
"tau"
],
"offsets": [
[
52,
55
]
],
"normalized": []
},
{
"id": "split_0_train_3042_entity",
"type": "progene_text",
"text": [
"tau"
],
"offsets": [
[
62,
65
]
],
"normalized": []
},
{
"id": "split_0_train_3043_entity",
"type": "progene_text",
"text": [
"beta-amyloid"
],
"offsets": [
[
106,
118
]
],
"normalized": []
},
{
"id": "split_0_train_3044_entity",
"type": "progene_text",
"text": [
"Abeta42"
],
"offsets": [
[
121,
128
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2028 | split_0_train_2028 | [
{
"id": "split_0_train_2028_passage",
"type": "progene_text",
"text": [
"These CSF markers are particularly useful to discriminate early or incipient AD from age - associated memory impairment , depression , and some secondary dementias ."
],
"offsets": [
[
0,
165
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2029 | split_0_train_2029 | [
{
"id": "split_0_train_2029_passage",
"type": "progene_text",
"text": [
"In order to discriminate AD from other primary dementia disorders , however , more accurate and specific markers are needed ."
],
"offsets": [
[
0,
125
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2030 | split_0_train_2030 | [
{
"id": "split_0_train_2030_passage",
"type": "progene_text",
"text": [
"Preliminary evidence strongly suggests that quantification of tau phosphorylated at specific sites in CSF improves early detection , differential diagnosis , and tracking of disease progression in AD ."
],
"offsets": [
[
0,
201
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2031 | split_0_train_2031 | [
{
"id": "split_0_train_2031_passage",
"type": "progene_text",
"text": [
"Expression of the genes of methyl - binding domain proteins in human gliomas ."
],
"offsets": [
[
0,
78
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2032 | split_0_train_2032 | [
{
"id": "split_0_train_2032_passage",
"type": "progene_text",
"text": [
"DNA methylation is the most common epigenetic alteration in tumor genomes and might result in transcriptional repression of tumor suppressor genes ."
],
"offsets": [
[
0,
148
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2033 | split_0_train_2033 | [
{
"id": "split_0_train_2033_passage",
"type": "progene_text",
"text": [
"Moreover , recent results have demonstrated that both specific methylation patterns and functional components of the mismatch repair system are involved in the development of therapy resistance of tumor cells ."
],
"offsets": [
[
0,
210
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2034 | split_0_train_2034 | [
{
"id": "split_0_train_2034_passage",
"type": "progene_text",
"text": [
"Here we investigated the expression of the genes of methyl binding domain containing proteins ( MBD ) in human gliomas both in vivo and in vitro ."
],
"offsets": [
[
0,
146
]
]
}
]
| [
{
"id": "split_0_train_3045_entity",
"type": "progene_text",
"text": [
"MBD"
],
"offsets": [
[
96,
99
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2035 | split_0_train_2035 | [
{
"id": "split_0_train_2035_passage",
"type": "progene_text",
"text": [
"We found expression of MBDs including MBD1 , MBD2 , MBD3 and MBD4 / MED1 in all glioma cell lines and glioma biopsies ."
],
"offsets": [
[
0,
119
]
]
}
]
| [
{
"id": "split_0_train_3046_entity",
"type": "progene_text",
"text": [
"MBDs"
],
"offsets": [
[
23,
27
]
],
"normalized": []
},
{
"id": "split_0_train_3047_entity",
"type": "progene_text",
"text": [
"MBD1"
],
"offsets": [
[
38,
42
]
],
"normalized": []
},
{
"id": "split_0_train_3048_entity",
"type": "progene_text",
"text": [
"MBD2"
],
"offsets": [
[
45,
49
]
],
"normalized": []
},
{
"id": "split_0_train_3049_entity",
"type": "progene_text",
"text": [
"MBD3"
],
"offsets": [
[
52,
56
]
],
"normalized": []
},
{
"id": "split_0_train_3050_entity",
"type": "progene_text",
"text": [
"MBD4"
],
"offsets": [
[
61,
65
]
],
"normalized": []
},
{
"id": "split_0_train_3051_entity",
"type": "progene_text",
"text": [
"MED1"
],
"offsets": [
[
68,
72
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2036 | split_0_train_2036 | [
{
"id": "split_0_train_2036_passage",
"type": "progene_text",
"text": [
"No differences existed in vitro with regard to individual MBDs and individual cell lines ."
],
"offsets": [
[
0,
90
]
]
}
]
| [
{
"id": "split_0_train_3052_entity",
"type": "progene_text",
"text": [
"MBDs"
],
"offsets": [
[
58,
62
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2037 | split_0_train_2037 | [
{
"id": "split_0_train_2037_passage",
"type": "progene_text",
"text": [
"In vivo , MBD1 and MBD2 were also expressed in all biopsies with only minor differences between individual tumors ."
],
"offsets": [
[
0,
115
]
]
}
]
| [
{
"id": "split_0_train_3053_entity",
"type": "progene_text",
"text": [
"MBD1"
],
"offsets": [
[
10,
14
]
],
"normalized": []
},
{
"id": "split_0_train_3054_entity",
"type": "progene_text",
"text": [
"MBD2"
],
"offsets": [
[
19,
23
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2038 | split_0_train_2038 | [
{
"id": "split_0_train_2038_passage",
"type": "progene_text",
"text": [
"MBD3 and MBD4 / MED1 , however , showed a correlation of expression with the grade of malignancy ."
],
"offsets": [
[
0,
98
]
]
}
]
| [
{
"id": "split_0_train_3055_entity",
"type": "progene_text",
"text": [
"MBD3"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_3056_entity",
"type": "progene_text",
"text": [
"MBD4"
],
"offsets": [
[
9,
13
]
],
"normalized": []
},
{
"id": "split_0_train_3057_entity",
"type": "progene_text",
"text": [
"MED1"
],
"offsets": [
[
16,
20
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2039 | split_0_train_2039 | [
{
"id": "split_0_train_2039_passage",
"type": "progene_text",
"text": [
"Astrocytomas and anaplastic astrocytomas showed a weak expression compared with a high expression in glioblastoma multiforme ."
],
"offsets": [
[
0,
126
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2040 | split_0_train_2040 | [
{
"id": "split_0_train_2040_passage",
"type": "progene_text",
"text": [
"Influence of delayed isotopic equilibration in urine on the accuracy of the (2)H(2)(18)O method in the elderly ."
],
"offsets": [
[
0,
112
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2041 | split_0_train_2041 | [
{
"id": "split_0_train_2041_passage",
"type": "progene_text",
"text": [
"Isotopic determination of total energy expenditure ( TEE ) by the doubly labeled water ( DLW ) method may be affected by urine retention in the elderly ."
],
"offsets": [
[
0,
153
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2042 | split_0_train_2042 | [
{
"id": "split_0_train_2042_passage",
"type": "progene_text",
"text": [
"The isotopic enrichments in urine and plasma sampled simultaneously 4 h post - DLW dose were compared in a subset of 281 subjects [ 139 women , 142 men , 75 +/- 3 ( SD ) yr ] of the 3,075 participants in the Health , Aging , and Body Composition study ."
],
"offsets": [
[
0,
253
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2043 | split_0_train_2043 | [
{
"id": "split_0_train_2043_passage",
"type": "progene_text",
"text": [
"Based on analytic precisions , a +/- 2 % urine - plasma difference was set as the cut - off value ."
],
"offsets": [
[
0,
99
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2044 | split_0_train_2044 | [
{
"id": "split_0_train_2044_passage",
"type": "progene_text",
"text": [
"Ten percent of the population presented a difference lower than - 2 % , suggesting a delay in urine isotopic equilibration ."
],
"offsets": [
[
0,
124
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2045 | split_0_train_2045 | [
{
"id": "split_0_train_2045_passage",
"type": "progene_text",
"text": [
"This - 13 +/- 10 % urine - plasma difference was not linked to analytic errors , illnesses , the sampling time , or the time and quantity of water intake , suggesting that urine retention may be the main factor ."
],
"offsets": [
[
0,
212
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2046 | split_0_train_2046 | [
{
"id": "split_0_train_2046_passage",
"type": "progene_text",
"text": [
"The consequences are an 18 +/- 13 and 21 +/- 16 % overestimation of the total body water and the TEE , respectively ."
],
"offsets": [
[
0,
117
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2047 | split_0_train_2047 | [
{
"id": "split_0_train_2047_passage",
"type": "progene_text",
"text": [
"Unexpectedly , 21 % of the population presented a urine - plasma difference higher than +/- 2 % that resulted , however , in a nonsignificant TEE underestimation of - 3 +/- 5 % ."
],
"offsets": [
[
0,
178
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2048 | split_0_train_2048 | [
{
"id": "split_0_train_2048_passage",
"type": "progene_text",
"text": [
"In conclusion , the delayed isotopic equilibration observed in urine reduces the accuracy of the DLW method in the elderly ."
],
"offsets": [
[
0,
124
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2049 | split_0_train_2049 | [
{
"id": "split_0_train_2049_passage",
"type": "progene_text",
"text": [
"It is recommended , when blood sampling is impossible , to adopt the intercept method with urine sampling 24 h postdose ."
],
"offsets": [
[
0,
121
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2050 | split_0_train_2050 | [
{
"id": "split_0_train_2050_passage",
"type": "progene_text",
"text": [
"Crystal structure of a ternary SAP-1 / SRF / c-fos SRE DNA complex ."
],
"offsets": [
[
0,
68
]
]
}
]
| [
{
"id": "split_0_train_3058_entity",
"type": "progene_text",
"text": [
"SAP-1"
],
"offsets": [
[
31,
36
]
],
"normalized": []
},
{
"id": "split_0_train_3059_entity",
"type": "progene_text",
"text": [
"SRF"
],
"offsets": [
[
39,
42
]
],
"normalized": []
},
{
"id": "split_0_train_3060_entity",
"type": "progene_text",
"text": [
"c-fos"
],
"offsets": [
[
45,
50
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2051 | split_0_train_2051 | [
{
"id": "split_0_train_2051_passage",
"type": "progene_text",
"text": [
"Combinatorial DNA binding by proteins for promoter - specific gene activation is a common mode of DNA regulation in eukaryotic organisms , and occurs at the promoter of the c-fos proto - oncogene ."
],
"offsets": [
[
0,
197
]
]
}
]
| [
{
"id": "split_0_train_3061_entity",
"type": "progene_text",
"text": [
"c-fos"
],
"offsets": [
[
173,
178
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2052 | split_0_train_2052 | [
{
"id": "split_0_train_2052_passage",
"type": "progene_text",
"text": [
"The c-fos promoter contains a serum response element ( SRE ) that mediates ternary complex formation with the Ets proteins SAP-1 or Elk-1 and the MADS - box protein , serum response factor ( SRF ) ."
],
"offsets": [
[
0,
198
]
]
}
]
| [
{
"id": "split_0_train_3062_entity",
"type": "progene_text",
"text": [
"c-fos"
],
"offsets": [
[
4,
9
]
],
"normalized": []
},
{
"id": "split_0_train_3063_entity",
"type": "progene_text",
"text": [
"Ets"
],
"offsets": [
[
110,
113
]
],
"normalized": []
},
{
"id": "split_0_train_3064_entity",
"type": "progene_text",
"text": [
"SAP-1"
],
"offsets": [
[
123,
128
]
],
"normalized": []
},
{
"id": "split_0_train_3065_entity",
"type": "progene_text",
"text": [
"Elk-1"
],
"offsets": [
[
132,
137
]
],
"normalized": []
},
{
"id": "split_0_train_3066_entity",
"type": "progene_text",
"text": [
"serum response factor"
],
"offsets": [
[
167,
188
]
],
"normalized": []
},
{
"id": "split_0_train_3067_entity",
"type": "progene_text",
"text": [
"SRF"
],
"offsets": [
[
191,
194
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2053 | split_0_train_2053 | [
{
"id": "split_0_train_2053_passage",
"type": "progene_text",
"text": [
"Here , we report the crystal structure of a ternary SAP-1 / SRF / c-fos SRE DNA complex containing the minimal DNA - binding domains of each protein ."
],
"offsets": [
[
0,
150
]
]
}
]
| [
{
"id": "split_0_train_3068_entity",
"type": "progene_text",
"text": [
"SAP-1"
],
"offsets": [
[
52,
57
]
],
"normalized": []
},
{
"id": "split_0_train_3069_entity",
"type": "progene_text",
"text": [
"SRF"
],
"offsets": [
[
60,
63
]
],
"normalized": []
},
{
"id": "split_0_train_3070_entity",
"type": "progene_text",
"text": [
"c-fos"
],
"offsets": [
[
66,
71
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2054 | split_0_train_2054 | [
{
"id": "split_0_train_2054_passage",
"type": "progene_text",
"text": [
"The structure of the complex reveals that the SAP-1 monomer and SRF dimer are bound on opposite faces of the DNA , and that the DNA recognition helix of SAP-1 makes direct contact with the DNA recognition helix of one of the two SRF subunits ."
],
"offsets": [
[
0,
243
]
]
}
]
| [
{
"id": "split_0_train_3071_entity",
"type": "progene_text",
"text": [
"SAP-1"
],
"offsets": [
[
46,
51
]
],
"normalized": []
},
{
"id": "split_0_train_3072_entity",
"type": "progene_text",
"text": [
"SRF"
],
"offsets": [
[
64,
67
]
],
"normalized": []
},
{
"id": "split_0_train_3073_entity",
"type": "progene_text",
"text": [
"SAP-1"
],
"offsets": [
[
153,
158
]
],
"normalized": []
},
{
"id": "split_0_train_3074_entity",
"type": "progene_text",
"text": [
"SRF"
],
"offsets": [
[
229,
232
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2055 | split_0_train_2055 | [
{
"id": "split_0_train_2055_passage",
"type": "progene_text",
"text": [
"These interactions facilitate an 82 degrees DNA bend around SRF and a modulation of protein - DNA contacts by each protein when compared to each of the binary DNA complexes ."
],
"offsets": [
[
0,
174
]
]
}
]
| [
{
"id": "split_0_train_3075_entity",
"type": "progene_text",
"text": [
"SRF"
],
"offsets": [
[
60,
63
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2056 | split_0_train_2056 | [
{
"id": "split_0_train_2056_passage",
"type": "progene_text",
"text": [
"A comparison with a recently determined complex containing SRF , an idealized DNA site , and a SAP-1 fragment containing a SRF - interacting B-box region , shows a similar overall architecture but also shows important differences ."
],
"offsets": [
[
0,
231
]
]
}
]
| [
{
"id": "split_0_train_3076_entity",
"type": "progene_text",
"text": [
"SRF"
],
"offsets": [
[
59,
62
]
],
"normalized": []
},
{
"id": "split_0_train_3077_entity",
"type": "progene_text",
"text": [
"SAP-1"
],
"offsets": [
[
95,
100
]
],
"normalized": []
},
{
"id": "split_0_train_3078_entity",
"type": "progene_text",
"text": [
"SRF"
],
"offsets": [
[
123,
126
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2057 | split_0_train_2057 | [
{
"id": "split_0_train_2057_passage",
"type": "progene_text",
"text": [
"Specifically , the comparison suggests that the B-box region of the Ets protein does not significantly influence DNA recognition by either of the proteins , and that the sequence of the DNA target effects the way in which the two proteins cooperate for DNA recognition ."
],
"offsets": [
[
0,
270
]
]
}
]
| [
{
"id": "split_0_train_3079_entity",
"type": "progene_text",
"text": [
"Ets"
],
"offsets": [
[
68,
71
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2058 | split_0_train_2058 | [
{
"id": "split_0_train_2058_passage",
"type": "progene_text",
"text": [
"These studies have implications for how DNA - bound SRF may modulate the DNA - binding properties of other Ets proteins such as Elk-1 , and for how other Ets proteins may modulate the DNA - binding properties of other DNA - bound accessory factors to facilitate promoter - specific transcriptional responses ."
],
"offsets": [
[
0,
309
]
]
}
]
| [
{
"id": "split_0_train_3080_entity",
"type": "progene_text",
"text": [
"SRF"
],
"offsets": [
[
52,
55
]
],
"normalized": []
},
{
"id": "split_0_train_3081_entity",
"type": "progene_text",
"text": [
"Ets"
],
"offsets": [
[
107,
110
]
],
"normalized": []
},
{
"id": "split_0_train_3082_entity",
"type": "progene_text",
"text": [
"Elk-1"
],
"offsets": [
[
128,
133
]
],
"normalized": []
},
{
"id": "split_0_train_3083_entity",
"type": "progene_text",
"text": [
"Ets"
],
"offsets": [
[
154,
157
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2059 | split_0_train_2059 | [
{
"id": "split_0_train_2059_passage",
"type": "progene_text",
"text": [
"KRIT1 association with the integrin - binding protein ICAP-1 : a new direction in the elucidation of cerebral cavernous malformations ( CCM1 ) pathogenesis ."
],
"offsets": [
[
0,
157
]
]
}
]
| [
{
"id": "split_0_train_3084_entity",
"type": "progene_text",
"text": [
"KRIT1"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "split_0_train_3085_entity",
"type": "progene_text",
"text": [
"integrin"
],
"offsets": [
[
27,
35
]
],
"normalized": []
},
{
"id": "split_0_train_3086_entity",
"type": "progene_text",
"text": [
"ICAP-1"
],
"offsets": [
[
54,
60
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2060 | split_0_train_2060 | [
{
"id": "split_0_train_2060_passage",
"type": "progene_text",
"text": [
"Mutations in KRIT1 , a protein initially identified based on a yeast two - hybrid interaction with the RAS - family GTPase RAP1A , are responsible for the development of the inherited vascular disorder cerebral cavernous malformations ( CCM1 ) ."
],
"offsets": [
[
0,
245
]
]
}
]
| [
{
"id": "split_0_train_3087_entity",
"type": "progene_text",
"text": [
"KRIT1"
],
"offsets": [
[
13,
18
]
],
"normalized": []
},
{
"id": "split_0_train_3088_entity",
"type": "progene_text",
"text": [
"RAS - family GTPase"
],
"offsets": [
[
103,
122
]
],
"normalized": []
},
{
"id": "split_0_train_3089_entity",
"type": "progene_text",
"text": [
"RAP1A"
],
"offsets": [
[
123,
128
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2061 | split_0_train_2061 | [
{
"id": "split_0_train_2061_passage",
"type": "progene_text",
"text": [
"As the function of the KRIT1 protein and its role in CCM pathogenesis remain unknown , we performed yeast two - hybrid screens to identify additional protein binding partners ."
],
"offsets": [
[
0,
176
]
]
}
]
| [
{
"id": "split_0_train_3090_entity",
"type": "progene_text",
"text": [
"KRIT1"
],
"offsets": [
[
23,
28
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2062 | split_0_train_2062 | [
{
"id": "split_0_train_2062_passage",
"type": "progene_text",
"text": [
"A fragment containing the N - terminal 272 amino acid residues of KRIT1 , a region lacking similarity to any known protein upon database searches , was used as bait ."
],
"offsets": [
[
0,
166
]
]
}
]
| [
{
"id": "split_0_train_3091_entity",
"type": "progene_text",
"text": [
"KRIT1"
],
"offsets": [
[
66,
71
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2063 | split_0_train_2063 | [
{
"id": "split_0_train_2063_passage",
"type": "progene_text",
"text": [
"From parallel screens of human fetal brain and HeLa cDNA libraries , we obtained multiple independent isolates of human integrin cytoplasmic domain - associated protein-1 ( ICAP-1 ) as interacting clones ."
],
"offsets": [
[
0,
205
]
]
}
]
| [
{
"id": "split_0_train_3092_entity",
"type": "progene_text",
"text": [
"integrin cytoplasmic domain - associated protein-1"
],
"offsets": [
[
120,
170
]
],
"normalized": []
},
{
"id": "split_0_train_3093_entity",
"type": "progene_text",
"text": [
"ICAP-1"
],
"offsets": [
[
173,
179
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2064 | split_0_train_2064 | [
{
"id": "split_0_train_2064_passage",
"type": "progene_text",
"text": [
"The interaction of KRIT1 and ICAP-1 was confirmed by GST - KRIT1 trapping of endogenous ICAP-1 from 293T cells ."
],
"offsets": [
[
0,
112
]
]
}
]
| [
{
"id": "split_0_train_3094_entity",
"type": "progene_text",
"text": [
"KRIT1"
],
"offsets": [
[
19,
24
]
],
"normalized": []
},
{
"id": "split_0_train_3095_entity",
"type": "progene_text",
"text": [
"ICAP-1"
],
"offsets": [
[
29,
35
]
],
"normalized": []
},
{
"id": "split_0_train_3096_entity",
"type": "progene_text",
"text": [
"GST"
],
"offsets": [
[
53,
56
]
],
"normalized": []
},
{
"id": "split_0_train_3097_entity",
"type": "progene_text",
"text": [
"KRIT1"
],
"offsets": [
[
59,
64
]
],
"normalized": []
},
{
"id": "split_0_train_3098_entity",
"type": "progene_text",
"text": [
"ICAP-1"
],
"offsets": [
[
88,
94
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2065 | split_0_train_2065 | [
{
"id": "split_0_train_2065_passage",
"type": "progene_text",
"text": [
"The alpha isoform of ICAP-1 is a 200 amino acid serine / threonine - rich phosphoprotein which binds the cytoplasmic tail of beta1 integrins ."
],
"offsets": [
[
0,
142
]
]
}
]
| [
{
"id": "split_0_train_3099_entity",
"type": "progene_text",
"text": [
"ICAP-1"
],
"offsets": [
[
21,
27
]
],
"normalized": []
},
{
"id": "split_0_train_3100_entity",
"type": "progene_text",
"text": [
"beta1 integrins"
],
"offsets": [
[
125,
140
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2066 | split_0_train_2066 | [
{
"id": "split_0_train_2066_passage",
"type": "progene_text",
"text": [
"We show that mutagenesis of the N - terminal KRIT1 NPXY amino acid sequence , a motif critical for ICAP-1 binding to beta1 integrin molecules , completely abrogates the KRIT1 / ICAP-1 interaction ."
],
"offsets": [
[
0,
197
]
]
}
]
| [
{
"id": "split_0_train_3101_entity",
"type": "progene_text",
"text": [
"KRIT1"
],
"offsets": [
[
45,
50
]
],
"normalized": []
},
{
"id": "split_0_train_3102_entity",
"type": "progene_text",
"text": [
"ICAP-1"
],
"offsets": [
[
99,
105
]
],
"normalized": []
},
{
"id": "split_0_train_3103_entity",
"type": "progene_text",
"text": [
"beta1 integrin"
],
"offsets": [
[
117,
131
]
],
"normalized": []
},
{
"id": "split_0_train_3104_entity",
"type": "progene_text",
"text": [
"KRIT1"
],
"offsets": [
[
169,
174
]
],
"normalized": []
},
{
"id": "split_0_train_3105_entity",
"type": "progene_text",
"text": [
"ICAP-1"
],
"offsets": [
[
177,
183
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2067 | split_0_train_2067 | [
{
"id": "split_0_train_2067_passage",
"type": "progene_text",
"text": [
"The interaction between ICAP-1 and KRIT1 , and the presence of a FERM domain in the latter , suggest that KRIT1 might be involved in the bidirectional signaling between integrin molecules and the cytoskeleton ."
],
"offsets": [
[
0,
210
]
]
}
]
| [
{
"id": "split_0_train_3106_entity",
"type": "progene_text",
"text": [
"ICAP-1"
],
"offsets": [
[
24,
30
]
],
"normalized": []
},
{
"id": "split_0_train_3107_entity",
"type": "progene_text",
"text": [
"KRIT1"
],
"offsets": [
[
35,
40
]
],
"normalized": []
},
{
"id": "split_0_train_3108_entity",
"type": "progene_text",
"text": [
"KRIT1"
],
"offsets": [
[
106,
111
]
],
"normalized": []
},
{
"id": "split_0_train_3109_entity",
"type": "progene_text",
"text": [
"integrin"
],
"offsets": [
[
169,
177
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2068 | split_0_train_2068 | [
{
"id": "split_0_train_2068_passage",
"type": "progene_text",
"text": [
"Furthermore , these data suggest that KRIT1 might affect cell adhesion processes via integrin signaling in CCM1 pathogenesis ."
],
"offsets": [
[
0,
126
]
]
}
]
| [
{
"id": "split_0_train_3110_entity",
"type": "progene_text",
"text": [
"KRIT1"
],
"offsets": [
[
38,
43
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2069 | split_0_train_2069 | [
{
"id": "split_0_train_2069_passage",
"type": "progene_text",
"text": [
"Allelic polymorphism synergizes with variable gene content to individualize human KIR genotype ."
],
"offsets": [
[
0,
96
]
]
}
]
| [
{
"id": "split_0_train_3111_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
82,
85
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2070 | split_0_train_2070 | [
{
"id": "split_0_train_2070_passage",
"type": "progene_text",
"text": [
"Killer Ig - like receptor ( KIR ) genes are a multigene family on human chromosome 19 ."
],
"offsets": [
[
0,
87
]
]
}
]
| [
{
"id": "split_0_train_3112_entity",
"type": "progene_text",
"text": [
"Killer Ig - like receptor"
],
"offsets": [
[
0,
25
]
],
"normalized": []
},
{
"id": "split_0_train_3113_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
28,
31
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2071 | split_0_train_2071 | [
{
"id": "split_0_train_2071_passage",
"type": "progene_text",
"text": [
"KIR genes occur in various combinations on different haplotypes ."
],
"offsets": [
[
0,
65
]
]
}
]
| [
{
"id": "split_0_train_3114_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
0,
3
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2072 | split_0_train_2072 | [
{
"id": "split_0_train_2072_passage",
"type": "progene_text",
"text": [
"Additionally , KIR genes are polymorphic ."
],
"offsets": [
[
0,
42
]
]
}
]
| [
{
"id": "split_0_train_3115_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
15,
18
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2073 | split_0_train_2073 | [
{
"id": "split_0_train_2073_passage",
"type": "progene_text",
"text": [
"To examine how allelic polymorphism diversifies KIR haplotypes with similar or identical combinations of KIR genes , we devised methods for discriminating alleles of KIR2DL1 , - 2DL3 , - 3DL1 , and - 3DL2 ."
],
"offsets": [
[
0,
206
]
]
}
]
| [
{
"id": "split_0_train_3116_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
48,
51
]
],
"normalized": []
},
{
"id": "split_0_train_3117_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
105,
108
]
],
"normalized": []
},
{
"id": "split_0_train_3118_entity",
"type": "progene_text",
"text": [
"KIR2DL1"
],
"offsets": [
[
166,
173
]
],
"normalized": []
},
{
"id": "split_0_train_3119_entity",
"type": "progene_text",
"text": [
"2DL3"
],
"offsets": [
[
178,
182
]
],
"normalized": []
},
{
"id": "split_0_train_3120_entity",
"type": "progene_text",
"text": [
"3DL1"
],
"offsets": [
[
187,
191
]
],
"normalized": []
},
{
"id": "split_0_train_3121_entity",
"type": "progene_text",
"text": [
"3DL2"
],
"offsets": [
[
200,
204
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2074 | split_0_train_2074 | [
{
"id": "split_0_train_2074_passage",
"type": "progene_text",
"text": [
"These methods were applied to 143 individuals from 34 families to define 98 independent KIR haplotypes at the allele level ."
],
"offsets": [
[
0,
124
]
]
}
]
| [
{
"id": "split_0_train_3122_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
88,
91
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2075 | split_0_train_2075 | [
{
"id": "split_0_train_2075_passage",
"type": "progene_text",
"text": [
"Three novel 3DL2 alleles and a chimeric 3DL1 / 3DL2 sequence were also identified ."
],
"offsets": [
[
0,
83
]
]
}
]
| [
{
"id": "split_0_train_3123_entity",
"type": "progene_text",
"text": [
"3DL2"
],
"offsets": [
[
12,
16
]
],
"normalized": []
},
{
"id": "split_0_train_3124_entity",
"type": "progene_text",
"text": [
"3DL1"
],
"offsets": [
[
40,
44
]
],
"normalized": []
},
{
"id": "split_0_train_3125_entity",
"type": "progene_text",
"text": [
"3DL2"
],
"offsets": [
[
47,
51
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2076 | split_0_train_2076 | [
{
"id": "split_0_train_2076_passage",
"type": "progene_text",
"text": [
"Among the A group haplotypes were 22 different combinations of 2DL1 , 2DL3 , 3DL1 , and 3DL2 alleles ."
],
"offsets": [
[
0,
102
]
]
}
]
| [
{
"id": "split_0_train_3126_entity",
"type": "progene_text",
"text": [
"2DL1"
],
"offsets": [
[
63,
67
]
],
"normalized": []
},
{
"id": "split_0_train_3127_entity",
"type": "progene_text",
"text": [
"2DL3"
],
"offsets": [
[
70,
74
]
],
"normalized": []
},
{
"id": "split_0_train_3128_entity",
"type": "progene_text",
"text": [
"3DL1"
],
"offsets": [
[
77,
81
]
],
"normalized": []
},
{
"id": "split_0_train_3129_entity",
"type": "progene_text",
"text": [
"3DL2"
],
"offsets": [
[
88,
92
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2077 | split_0_train_2077 | [
{
"id": "split_0_train_2077_passage",
"type": "progene_text",
"text": [
"Among the B group haplotypes that were unambiguously determined were 15 distinct haplotypes involving 9 different combinations of KIR genes ."
],
"offsets": [
[
0,
141
]
]
}
]
| [
{
"id": "split_0_train_3130_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
130,
133
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2078 | split_0_train_2078 | [
{
"id": "split_0_train_2078_passage",
"type": "progene_text",
"text": [
"A and B haplotypes both exhibit strong linkage disequilibrium ( LD ) between 2DL1 and 2DL3 alleles , and between 3DL1 and 3DL2 alleles ."
],
"offsets": [
[
0,
136
]
]
}
]
| [
{
"id": "split_0_train_3131_entity",
"type": "progene_text",
"text": [
"2DL1"
],
"offsets": [
[
77,
81
]
],
"normalized": []
},
{
"id": "split_0_train_3132_entity",
"type": "progene_text",
"text": [
"2DL3"
],
"offsets": [
[
86,
90
]
],
"normalized": []
},
{
"id": "split_0_train_3133_entity",
"type": "progene_text",
"text": [
"3DL1"
],
"offsets": [
[
113,
117
]
],
"normalized": []
},
{
"id": "split_0_train_3134_entity",
"type": "progene_text",
"text": [
"3DL2"
],
"offsets": [
[
122,
126
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2079 | split_0_train_2079 | [
{
"id": "split_0_train_2079_passage",
"type": "progene_text",
"text": [
"In contrast , there was little LD between the 2DL1 / 2DL3 and 3DL1 / 3DL2 pairs that define the two halves of the KIR gene complex ."
],
"offsets": [
[
0,
132
]
]
}
]
| [
{
"id": "split_0_train_3135_entity",
"type": "progene_text",
"text": [
"2DL1"
],
"offsets": [
[
46,
50
]
],
"normalized": []
},
{
"id": "split_0_train_3136_entity",
"type": "progene_text",
"text": [
"2DL3"
],
"offsets": [
[
53,
57
]
],
"normalized": []
},
{
"id": "split_0_train_3137_entity",
"type": "progene_text",
"text": [
"3DL1"
],
"offsets": [
[
62,
66
]
],
"normalized": []
},
{
"id": "split_0_train_3138_entity",
"type": "progene_text",
"text": [
"3DL2"
],
"offsets": [
[
69,
73
]
],
"normalized": []
},
{
"id": "split_0_train_3139_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
114,
117
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2080 | split_0_train_2080 | [
{
"id": "split_0_train_2080_passage",
"type": "progene_text",
"text": [
"The synergistic combination of allelic polymorphism and variable gene content individualize KIR genotype to an extent where unrelated individuals almost always have different KIR types ."
],
"offsets": [
[
0,
186
]
]
}
]
| [
{
"id": "split_0_train_3140_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
92,
95
]
],
"normalized": []
},
{
"id": "split_0_train_3141_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
175,
178
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2081 | split_0_train_2081 | [
{
"id": "split_0_train_2081_passage",
"type": "progene_text",
"text": [
"This level of diversity likely reflects strong pressure from pathogens on the human NK cell response ."
],
"offsets": [
[
0,
102
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2082 | split_0_train_2082 | [
{
"id": "split_0_train_2082_passage",
"type": "progene_text",
"text": [
"Human bronchial epithelium expresses interleukin-9 receptors and releases neutrophil chemotactic factor ."
],
"offsets": [
[
0,
105
]
]
}
]
| [
{
"id": "split_0_train_3142_entity",
"type": "progene_text",
"text": [
"interleukin-9 receptors"
],
"offsets": [
[
37,
60
]
],
"normalized": []
},
{
"id": "split_0_train_3143_entity",
"type": "progene_text",
"text": [
"neutrophil chemotactic factor"
],
"offsets": [
[
74,
103
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2083 | split_0_train_2083 | [
{
"id": "split_0_train_2083_passage",
"type": "progene_text",
"text": [
"Growing evidence obtained from human genomic analysis and antigen - challenged transgenic mice suggests that interleukin-9 ( IL-9 ) is a candidate factor in immunoglobulin E ( IgE ) production and thus is thought to be associated with bronchial inflammation and bronchial hyperresponsiveness ( BHR ) ."
],
"offsets": [
[
0,
301
]
]
}
]
| [
{
"id": "split_0_train_3144_entity",
"type": "progene_text",
"text": [
"interleukin-9"
],
"offsets": [
[
109,
122
]
],
"normalized": []
},
{
"id": "split_0_train_3145_entity",
"type": "progene_text",
"text": [
"IL-9"
],
"offsets": [
[
125,
129
]
],
"normalized": []
},
{
"id": "split_0_train_3146_entity",
"type": "progene_text",
"text": [
"immunoglobulin E"
],
"offsets": [
[
157,
173
]
],
"normalized": []
},
{
"id": "split_0_train_3147_entity",
"type": "progene_text",
"text": [
"IgE"
],
"offsets": [
[
176,
179
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2084 | split_0_train_2084 | [
{
"id": "split_0_train_2084_passage",
"type": "progene_text",
"text": [
"To evaluate the expression of the IL-9 receptor and its effect on the IL-9 human bronchial cell line BEAS-2B cells , reverse transcriptase - polymerase chain reaction ( RT - PCR ) , immunohistochemical investigation , and chemotaxis assay were performed ."
],
"offsets": [
[
0,
255
]
]
}
]
| [
{
"id": "split_0_train_3148_entity",
"type": "progene_text",
"text": [
"IL-9 receptor"
],
"offsets": [
[
34,
47
]
],
"normalized": []
},
{
"id": "split_0_train_3149_entity",
"type": "progene_text",
"text": [
"IL-9"
],
"offsets": [
[
70,
74
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2085 | split_0_train_2085 | [
{
"id": "split_0_train_2085_passage",
"type": "progene_text",
"text": [
"The components of the IL-9 receptor , consisting of IL-9 receptor alpha ( CD129 ) and IL-2 receptory ((1) 132 ) , were expressed on BEAS-2B cells as determined by RT - PCR and flow cytometry ."
],
"offsets": [
[
0,
192
]
]
}
]
| [
{
"id": "split_0_train_3150_entity",
"type": "progene_text",
"text": [
"IL-9 receptor"
],
"offsets": [
[
22,
35
]
],
"normalized": []
},
{
"id": "split_0_train_3151_entity",
"type": "progene_text",
"text": [
"IL-9 receptor alpha"
],
"offsets": [
[
52,
71
]
],
"normalized": []
},
{
"id": "split_0_train_3152_entity",
"type": "progene_text",
"text": [
"CD129"
],
"offsets": [
[
74,
79
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2086 | split_0_train_2086 | [
{
"id": "split_0_train_2086_passage",
"type": "progene_text",
"text": [
"BEAS-2B cells exposed to IL-9 released neutrophil chemotactic activity ( NCA ) in a time - and dose - dependent manner , and the presence of granulocyte colony - stimulating factor ( G-CSF ) was also detected ."
],
"offsets": [
[
0,
210
]
]
}
]
| [
{
"id": "split_0_train_3153_entity",
"type": "progene_text",
"text": [
"IL-9"
],
"offsets": [
[
25,
29
]
],
"normalized": []
},
{
"id": "split_0_train_3154_entity",
"type": "progene_text",
"text": [
"granulocyte colony - stimulating factor"
],
"offsets": [
[
141,
180
]
],
"normalized": []
},
{
"id": "split_0_train_3155_entity",
"type": "progene_text",
"text": [
"G-CSF"
],
"offsets": [
[
183,
188
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2087 | split_0_train_2087 | [
{
"id": "split_0_train_2087_passage",
"type": "progene_text",
"text": [
"This factor is primarily involved in NCA for the measurement of cytokines and in the inhibition assay of neutrophil chemotaxis ."
],
"offsets": [
[
0,
128
]
]
}
]
| [
{
"id": "split_0_train_3156_entity",
"type": "progene_text",
"text": [
"cytokines"
],
"offsets": [
[
64,
73
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2088 | split_0_train_2088 | [
{
"id": "split_0_train_2088_passage",
"type": "progene_text",
"text": [
"These findings suggest that bronchial epithelial cells may express IL-9 receptors , and that IL-9 may induce airway inflammation through the release of G-CSF from bronchial epithelial cells ."
],
"offsets": [
[
0,
191
]
]
}
]
| [
{
"id": "split_0_train_3157_entity",
"type": "progene_text",
"text": [
"IL-9 receptors"
],
"offsets": [
[
67,
81
]
],
"normalized": []
},
{
"id": "split_0_train_3158_entity",
"type": "progene_text",
"text": [
"IL-9"
],
"offsets": [
[
93,
97
]
],
"normalized": []
},
{
"id": "split_0_train_3159_entity",
"type": "progene_text",
"text": [
"G-CSF"
],
"offsets": [
[
152,
157
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2089 | split_0_train_2089 | [
{
"id": "split_0_train_2089_passage",
"type": "progene_text",
"text": [
"RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia ."
],
"offsets": [
[
0,
71
]
]
}
]
| [
{
"id": "split_0_train_3160_entity",
"type": "progene_text",
"text": [
"RasGRP4"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "split_0_train_3161_entity",
"type": "progene_text",
"text": [
"Ras"
],
"offsets": [
[
19,
22
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2090 | split_0_train_2090 | [
{
"id": "split_0_train_2090_passage",
"type": "progene_text",
"text": [
"Although a number of genetic defects are commonly associated with acute myeloid leukemia ( AML ) , a large percentage of AML cases are cytogenetically normal ."
],
"offsets": [
[
0,
159
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2091 | split_0_train_2091 | [
{
"id": "split_0_train_2091_passage",
"type": "progene_text",
"text": [
"This suggests a functional screen for transforming genes is required to identify genetic mutations that are missed by cytogenetic analyses ."
],
"offsets": [
[
0,
140
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2092 | split_0_train_2092 | [
{
"id": "split_0_train_2092_passage",
"type": "progene_text",
"text": [
"We utilized a retrovirus - based cDNA expression system to identify transforming genes expressed in cytogenetically normal AML patients ."
],
"offsets": [
[
0,
137
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2093 | split_0_train_2093 | [
{
"id": "split_0_train_2093_passage",
"type": "progene_text",
"text": [
"We identified a new member of the Ras guanyl nucleotide - releasing protein ( RasGRP ) family of Ras guanine nucleotide exchange factors , designating it RasGRP4 ."
],
"offsets": [
[
0,
163
]
]
}
]
| [
{
"id": "split_0_train_3162_entity",
"type": "progene_text",
"text": [
"Ras guanyl nucleotide - releasing protein ( RasGRP ) family"
],
"offsets": [
[
34,
93
]
],
"normalized": []
},
{
"id": "split_0_train_3163_entity",
"type": "progene_text",
"text": [
"Ras guanine nucleotide exchange factors"
],
"offsets": [
[
97,
136
]
],
"normalized": []
},
{
"id": "split_0_train_3164_entity",
"type": "progene_text",
"text": [
"RasGRP4"
],
"offsets": [
[
154,
161
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2094 | split_0_train_2094 | [
{
"id": "split_0_train_2094_passage",
"type": "progene_text",
"text": [
"Subsequently , cDNA sequences encoding rodent and human RasGRP4 proteins were deposited in GenBank ."
],
"offsets": [
[
0,
100
]
]
}
]
| [
{
"id": "split_0_train_3165_entity",
"type": "progene_text",
"text": [
"RasGRP4"
],
"offsets": [
[
56,
63
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2095 | split_0_train_2095 | [
{
"id": "split_0_train_2095_passage",
"type": "progene_text",
"text": [
"RasGRP4 contains the same protein domain structure as other members of the RasGRP family , including a Ras exchange motif , a CDC25 homology domain , a C1 / diacyglycerol - binding domain , and putative calcium - binding EF hands ."
],
"offsets": [
[
0,
231
]
]
}
]
| [
{
"id": "split_0_train_3166_entity",
"type": "progene_text",
"text": [
"RasGRP4"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "split_0_train_3167_entity",
"type": "progene_text",
"text": [
"RasGRP family"
],
"offsets": [
[
75,
88
]
],
"normalized": []
},
{
"id": "split_0_train_3168_entity",
"type": "progene_text",
"text": [
"Ras"
],
"offsets": [
[
103,
106
]
],
"normalized": []
},
{
"id": "split_0_train_3169_entity",
"type": "progene_text",
"text": [
"CDC25"
],
"offsets": [
[
126,
131
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2096 | split_0_train_2096 | [
{
"id": "split_0_train_2096_passage",
"type": "progene_text",
"text": [
"We show that expression of RasGRP4 induces anchorage - independent growth of Rat1 fibroblasts ."
],
"offsets": [
[
0,
95
]
]
}
]
| [
{
"id": "split_0_train_3170_entity",
"type": "progene_text",
"text": [
"RasGRP4"
],
"offsets": [
[
27,
34
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2097 | split_0_train_2097 | [
{
"id": "split_0_train_2097_passage",
"type": "progene_text",
"text": [
"RasGRP4 is a Ras - specific activator and , interestingly , is highly expressed in peripheral blood leukocytes and myeloid cell lines ."
],
"offsets": [
[
0,
135
]
]
}
]
| [
{
"id": "split_0_train_3171_entity",
"type": "progene_text",
"text": [
"RasGRP4"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "split_0_train_3172_entity",
"type": "progene_text",
"text": [
"Ras"
],
"offsets": [
[
13,
16
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2098 | split_0_train_2098 | [
{
"id": "split_0_train_2098_passage",
"type": "progene_text",
"text": [
"Unlike other RasGRP proteins , RasGRP4 is not expressed in the brain or in lymphoid cells ."
],
"offsets": [
[
0,
91
]
]
}
]
| [
{
"id": "split_0_train_3173_entity",
"type": "progene_text",
"text": [
"RasGRP"
],
"offsets": [
[
13,
19
]
],
"normalized": []
},
{
"id": "split_0_train_3174_entity",
"type": "progene_text",
"text": [
"RasGRP4"
],
"offsets": [
[
31,
38
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2099 | split_0_train_2099 | [
{
"id": "split_0_train_2099_passage",
"type": "progene_text",
"text": [
"We demonstrated that 32D myeloid cells expressing RasGRP4 have elevated levels of activated Ras compared with control cells , and phorbol 12-myristate 13-acetate ( PMA ) treatment greatly enhanced Ras activation ."
],
"offsets": [
[
0,
213
]
]
}
]
| [
{
"id": "split_0_train_3175_entity",
"type": "progene_text",
"text": [
"RasGRP4"
],
"offsets": [
[
50,
57
]
],
"normalized": []
},
{
"id": "split_0_train_3176_entity",
"type": "progene_text",
"text": [
"Ras"
],
"offsets": [
[
92,
95
]
],
"normalized": []
},
{
"id": "split_0_train_3177_entity",
"type": "progene_text",
"text": [
"Ras"
],
"offsets": [
[
197,
200
]
],
"normalized": []
}
]
| []
| []
| []
|
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