id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_2200 | split_0_train_2200 | [
{
"id": "split_0_train_2200_passage",
"type": "progene_text",
"text": [
"We have recently identified a gene ( the WFIKKN gene ) on human chromosome 16 ( 16p13.3 ) that encodes a secreted protein containing WAP - type , Follistatin / Kazal type , Kunitz - type and NTR - type protease - inhibitory modules and an Immunoglobulin domain [ Trexler et al. , Proc. Natl. Acad. Sci. USA 98 ( 2001 ) , 3705 - 3709 ] ."
],
"offsets": [
[
0,
336
]
]
}
]
| [
{
"id": "split_0_train_3233_entity",
"type": "progene_text",
"text": [
"WFIKKN"
],
"offsets": [
[
41,
47
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],
"normalized": []
},
{
"id": "split_0_train_3234_entity",
"type": "progene_text",
"text": [
"WAP - type , Follistatin / Kazal type , Kunitz - type and NTR - type protease"
],
"offsets": [
[
133,
210
]
],
"normalized": []
},
{
"id": "split_0_train_3235_entity",
"type": "progene_text",
"text": [
"Immunoglobulin"
],
"offsets": [
[
239,
253
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2201 | split_0_train_2201 | [
{
"id": "split_0_train_2201_passage",
"type": "progene_text",
"text": [
"In the present work we show that a gene on chromosome 17 encodes a WFIKKN - related protein ( WFIKKNRP ) that has the same domain organization as the WFIKKN protein ."
],
"offsets": [
[
0,
166
]
]
}
]
| [
{
"id": "split_0_train_3236_entity",
"type": "progene_text",
"text": [
"WFIKKN - related protein"
],
"offsets": [
[
67,
91
]
],
"normalized": []
},
{
"id": "split_0_train_3237_entity",
"type": "progene_text",
"text": [
"WFIKKNRP"
],
"offsets": [
[
94,
102
]
],
"normalized": []
},
{
"id": "split_0_train_3238_entity",
"type": "progene_text",
"text": [
"WFIKKN"
],
"offsets": [
[
150,
156
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2202 | split_0_train_2202 | [
{
"id": "split_0_train_2202_passage",
"type": "progene_text",
"text": [
"The exon - intron structure of the two genes is also similar as both genes have a single phase 0 intron that splits their WAP domains in equivalent positions ."
],
"offsets": [
[
0,
159
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2203 | split_0_train_2203 | [
{
"id": "split_0_train_2203_passage",
"type": "progene_text",
"text": [
"In view of the presence of several protease inhibitory modules in these proteins it seems likely that they serve to control the action of multiple types of proteases ."
],
"offsets": [
[
0,
167
]
]
}
]
| [
{
"id": "split_0_train_3239_entity",
"type": "progene_text",
"text": [
"protease"
],
"offsets": [
[
35,
43
]
],
"normalized": []
},
{
"id": "split_0_train_3240_entity",
"type": "progene_text",
"text": [
"proteases"
],
"offsets": [
[
156,
165
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2204 | split_0_train_2204 | [
{
"id": "split_0_train_2204_passage",
"type": "progene_text",
"text": [
"The tissue expression pattern of the two proteins , however , is markedly different suggesting that they have distinct biological roles ."
],
"offsets": [
[
0,
137
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2205 | split_0_train_2205 | [
{
"id": "split_0_train_2205_passage",
"type": "progene_text",
"text": [
"Whereas the WFIKKN gene is expressed primarily in adult pancreas , liver and thymus but not in brain and ovary , significant expression of the WFIKKNRP gene is observed in ovary , testis and brain , but not in liver ."
],
"offsets": [
[
0,
217
]
]
}
]
| [
{
"id": "split_0_train_3241_entity",
"type": "progene_text",
"text": [
"WFIKKN"
],
"offsets": [
[
12,
18
]
],
"normalized": []
},
{
"id": "split_0_train_3242_entity",
"type": "progene_text",
"text": [
"WFIKKNRP"
],
"offsets": [
[
143,
151
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2206 | split_0_train_2206 | [
{
"id": "split_0_train_2206_passage",
"type": "progene_text",
"text": [
"Pronounced differences could also be seen in the case of fetal tissues : expression of the WFIKKN gene was highest in the lung , skeletal muscle and liver , whereas the WFIKKNRP gene was expressed primarily in brain , skeletal muscle , thymus and kidney ."
],
"offsets": [
[
0,
255
]
]
}
]
| [
{
"id": "split_0_train_3243_entity",
"type": "progene_text",
"text": [
"WFIKKN"
],
"offsets": [
[
91,
97
]
],
"normalized": []
},
{
"id": "split_0_train_3244_entity",
"type": "progene_text",
"text": [
"WFIKKNRP"
],
"offsets": [
[
169,
177
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2207 | split_0_train_2207 | [
{
"id": "split_0_train_2207_passage",
"type": "progene_text",
"text": [
"GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors ."
],
"offsets": [
[
0,
121
]
]
}
]
| [
{
"id": "split_0_train_3245_entity",
"type": "progene_text",
"text": [
"GGA"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_3246_entity",
"type": "progene_text",
"text": [
"ADP-ribosylation factors"
],
"offsets": [
[
95,
119
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2208 | split_0_train_2208 | [
{
"id": "split_0_train_2208_passage",
"type": "progene_text",
"text": [
"ADP-ribosylation factors ( ARFs ) are a family of small GTPases that are involved in various aspects of membrane trafficking events ."
],
"offsets": [
[
0,
133
]
]
}
]
| [
{
"id": "split_0_train_3247_entity",
"type": "progene_text",
"text": [
"ADP-ribosylation factors"
],
"offsets": [
[
0,
24
]
],
"normalized": []
},
{
"id": "split_0_train_3248_entity",
"type": "progene_text",
"text": [
"ARFs"
],
"offsets": [
[
27,
31
]
],
"normalized": []
},
{
"id": "split_0_train_3249_entity",
"type": "progene_text",
"text": [
"small GTPases"
],
"offsets": [
[
50,
63
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2209 | split_0_train_2209 | [
{
"id": "split_0_train_2209_passage",
"type": "progene_text",
"text": [
"These include ARF1 - ARF6 , which are divided into three classes on the basis of similarity in the primary structure : Class I , ARF1-ARF3 ; Class II , ARF4 and ARF5 ; and Class III , ARF6 ."
],
"offsets": [
[
0,
190
]
]
}
]
| [
{
"id": "split_0_train_3250_entity",
"type": "progene_text",
"text": [
"ARF1 - ARF6"
],
"offsets": [
[
14,
25
]
],
"normalized": []
},
{
"id": "split_0_train_3251_entity",
"type": "progene_text",
"text": [
"ARF1-ARF3"
],
"offsets": [
[
129,
138
]
],
"normalized": []
},
{
"id": "split_0_train_3252_entity",
"type": "progene_text",
"text": [
"ARF4"
],
"offsets": [
[
152,
156
]
],
"normalized": []
},
{
"id": "split_0_train_3253_entity",
"type": "progene_text",
"text": [
"ARF5"
],
"offsets": [
[
161,
165
]
],
"normalized": []
},
{
"id": "split_0_train_3254_entity",
"type": "progene_text",
"text": [
"ARF6"
],
"offsets": [
[
184,
188
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2210 | split_0_train_2210 | [
{
"id": "split_0_train_2210_passage",
"type": "progene_text",
"text": [
"Previous studies identified a novel family of potential ARF effectors , termed GGA1 - GGA3 , which interact specifically with GTP - bound ARF1 and ARF3 and are localized to the trans - Golgi network ( TGN ) or its related compartment (s) ( GGA is an abbreviation for Golgi - localizing , gamma-adaptin ear homology domain , ARF-binding protein ) ."
],
"offsets": [
[
0,
347
]
]
}
]
| [
{
"id": "split_0_train_3255_entity",
"type": "progene_text",
"text": [
"ARF"
],
"offsets": [
[
56,
59
]
],
"normalized": []
},
{
"id": "split_0_train_3256_entity",
"type": "progene_text",
"text": [
"GGA1 - GGA3"
],
"offsets": [
[
79,
90
]
],
"normalized": []
},
{
"id": "split_0_train_3257_entity",
"type": "progene_text",
"text": [
"ARF1"
],
"offsets": [
[
138,
142
]
],
"normalized": []
},
{
"id": "split_0_train_3258_entity",
"type": "progene_text",
"text": [
"ARF3"
],
"offsets": [
[
147,
151
]
],
"normalized": []
},
{
"id": "split_0_train_3259_entity",
"type": "progene_text",
"text": [
"GGA"
],
"offsets": [
[
240,
243
]
],
"normalized": []
},
{
"id": "split_0_train_3260_entity",
"type": "progene_text",
"text": [
"Golgi - localizing , gamma-adaptin ear homology domain , ARF-binding protein"
],
"offsets": [
[
267,
343
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2211 | split_0_train_2211 | [
{
"id": "split_0_train_2211_passage",
"type": "progene_text",
"text": [
"In the present study we have shown that ARF proteins belonging to the three classes , ARF1 , ARF5 and ARF6 , can interact with all GGA proteins in a yeast two - hybrid assay , in vitro and in vivo ."
],
"offsets": [
[
0,
198
]
]
}
]
| [
{
"id": "split_0_train_3261_entity",
"type": "progene_text",
"text": [
"ARF"
],
"offsets": [
[
40,
43
]
],
"normalized": []
},
{
"id": "split_0_train_3262_entity",
"type": "progene_text",
"text": [
"ARF1"
],
"offsets": [
[
86,
90
]
],
"normalized": []
},
{
"id": "split_0_train_3263_entity",
"type": "progene_text",
"text": [
"ARF5"
],
"offsets": [
[
93,
97
]
],
"normalized": []
},
{
"id": "split_0_train_3264_entity",
"type": "progene_text",
"text": [
"ARF6"
],
"offsets": [
[
102,
106
]
],
"normalized": []
},
{
"id": "split_0_train_3265_entity",
"type": "progene_text",
"text": [
"GGA"
],
"offsets": [
[
131,
134
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2212 | split_0_train_2212 | [
{
"id": "split_0_train_2212_passage",
"type": "progene_text",
"text": [
"Segmentation of GGA proteins and isolation of GGA mutants defective in ARF binding have revealed that a limited region within the GGA homology domain , which is conserved in the GGA family , is essential for ARF binding ."
],
"offsets": [
[
0,
221
]
]
}
]
| [
{
"id": "split_0_train_3266_entity",
"type": "progene_text",
"text": [
"GGA"
],
"offsets": [
[
16,
19
]
],
"normalized": []
},
{
"id": "split_0_train_3267_entity",
"type": "progene_text",
"text": [
"GGA"
],
"offsets": [
[
46,
49
]
],
"normalized": []
},
{
"id": "split_0_train_3268_entity",
"type": "progene_text",
"text": [
"ARF"
],
"offsets": [
[
71,
74
]
],
"normalized": []
},
{
"id": "split_0_train_3269_entity",
"type": "progene_text",
"text": [
"GGA"
],
"offsets": [
[
130,
133
]
],
"normalized": []
},
{
"id": "split_0_train_3270_entity",
"type": "progene_text",
"text": [
"GGA family"
],
"offsets": [
[
178,
188
]
],
"normalized": []
},
{
"id": "split_0_train_3271_entity",
"type": "progene_text",
"text": [
"ARF"
],
"offsets": [
[
208,
211
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2213 | split_0_train_2213 | [
{
"id": "split_0_train_2213_passage",
"type": "progene_text",
"text": [
"Expression in cells of GTPase - restricted mutants of ARF1 and ARF5 blocks dissociation of GGA proteins from membranes induced by brefeldin A ."
],
"offsets": [
[
0,
143
]
]
}
]
| [
{
"id": "split_0_train_3272_entity",
"type": "progene_text",
"text": [
"GTPase"
],
"offsets": [
[
23,
29
]
],
"normalized": []
},
{
"id": "split_0_train_3273_entity",
"type": "progene_text",
"text": [
"ARF1"
],
"offsets": [
[
54,
58
]
],
"normalized": []
},
{
"id": "split_0_train_3274_entity",
"type": "progene_text",
"text": [
"ARF5"
],
"offsets": [
[
63,
67
]
],
"normalized": []
},
{
"id": "split_0_train_3275_entity",
"type": "progene_text",
"text": [
"GGA"
],
"offsets": [
[
91,
94
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2214 | split_0_train_2214 | [
{
"id": "split_0_train_2214_passage",
"type": "progene_text",
"text": [
"However , neither of the ARF mutants recruits GGA mutants defective in ARF binding ."
],
"offsets": [
[
0,
84
]
]
}
]
| [
{
"id": "split_0_train_3276_entity",
"type": "progene_text",
"text": [
"ARF"
],
"offsets": [
[
25,
28
]
],
"normalized": []
},
{
"id": "split_0_train_3277_entity",
"type": "progene_text",
"text": [
"GGA"
],
"offsets": [
[
46,
49
]
],
"normalized": []
},
{
"id": "split_0_train_3278_entity",
"type": "progene_text",
"text": [
"ARF"
],
"offsets": [
[
71,
74
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2215 | split_0_train_2215 | [
{
"id": "split_0_train_2215_passage",
"type": "progene_text",
"text": [
"On the basis of these observations , we conclude that at least ARF1 ( Class I ) and ARF5 ( Class II ) in their GTP - bound state cause recruitment of GGA proteins on to TGN membranes ."
],
"offsets": [
[
0,
184
]
]
}
]
| [
{
"id": "split_0_train_3279_entity",
"type": "progene_text",
"text": [
"ARF1"
],
"offsets": [
[
63,
67
]
],
"normalized": []
},
{
"id": "split_0_train_3280_entity",
"type": "progene_text",
"text": [
"ARF5"
],
"offsets": [
[
84,
88
]
],
"normalized": []
},
{
"id": "split_0_train_3281_entity",
"type": "progene_text",
"text": [
"GGA"
],
"offsets": [
[
150,
153
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2216 | split_0_train_2216 | [
{
"id": "split_0_train_2216_passage",
"type": "progene_text",
"text": [
"In contrast , on the basis of similar experiments , ARF6 ( Class III ) may be involved in recruitment of GGA proteins to other compartments , possibly early endosomes ."
],
"offsets": [
[
0,
168
]
]
}
]
| [
{
"id": "split_0_train_3282_entity",
"type": "progene_text",
"text": [
"ARF6"
],
"offsets": [
[
52,
56
]
],
"normalized": []
},
{
"id": "split_0_train_3283_entity",
"type": "progene_text",
"text": [
"GGA"
],
"offsets": [
[
105,
108
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2217 | split_0_train_2217 | [
{
"id": "split_0_train_2217_passage",
"type": "progene_text",
"text": [
"Inhibition of BACE , a promising approach to Alzheimer ' s disease therapy ."
],
"offsets": [
[
0,
76
]
]
}
]
| [
{
"id": "split_0_train_3284_entity",
"type": "progene_text",
"text": [
"BACE"
],
"offsets": [
[
14,
18
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2218 | split_0_train_2218 | [
{
"id": "split_0_train_2218_passage",
"type": "progene_text",
"text": [
"The first proteolytic step in the processing of amyloid precursor protein ( APP ) to amyloid - beta ( Abeta ) in the brain is performed by beta - site APP cleaving enzyme ( BACE1 ) ."
],
"offsets": [
[
0,
182
]
]
}
]
| [
{
"id": "split_0_train_3285_entity",
"type": "progene_text",
"text": [
"amyloid precursor protein"
],
"offsets": [
[
48,
73
]
],
"normalized": []
},
{
"id": "split_0_train_3286_entity",
"type": "progene_text",
"text": [
"APP"
],
"offsets": [
[
76,
79
]
],
"normalized": []
},
{
"id": "split_0_train_3287_entity",
"type": "progene_text",
"text": [
"beta - site APP cleaving enzyme"
],
"offsets": [
[
139,
170
]
],
"normalized": []
},
{
"id": "split_0_train_3288_entity",
"type": "progene_text",
"text": [
"BACE1"
],
"offsets": [
[
173,
178
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2219 | split_0_train_2219 | [
{
"id": "split_0_train_2219_passage",
"type": "progene_text",
"text": [
"This enzyme is a membrane bound aspartic protease with high homology of the catalytic domain to renin and pepsin and of yet unknown physiologic function ."
],
"offsets": [
[
0,
154
]
]
}
]
| [
{
"id": "split_0_train_3289_entity",
"type": "progene_text",
"text": [
"aspartic protease"
],
"offsets": [
[
32,
49
]
],
"normalized": []
},
{
"id": "split_0_train_3290_entity",
"type": "progene_text",
"text": [
"renin"
],
"offsets": [
[
96,
101
]
],
"normalized": []
},
{
"id": "split_0_train_3291_entity",
"type": "progene_text",
"text": [
"pepsin"
],
"offsets": [
[
106,
112
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2220 | split_0_train_2220 | [
{
"id": "split_0_train_2220_passage",
"type": "progene_text",
"text": [
"It is a primary drug discovery target for Alzheimer s disease therapy ."
],
"offsets": [
[
0,
71
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2221 | split_0_train_2221 | [
{
"id": "split_0_train_2221_passage",
"type": "progene_text",
"text": [
"The first potent inhibitors are based on the sequence of APP around the beta-secretase cleavage site EVNL / DAEF , with the scissile Leu - Asp amide bond being replaced by a hydroxyethylene transition state analogue isostere ."
],
"offsets": [
[
0,
226
]
]
}
]
| [
{
"id": "split_0_train_3292_entity",
"type": "progene_text",
"text": [
"APP"
],
"offsets": [
[
57,
60
]
],
"normalized": []
},
{
"id": "split_0_train_3293_entity",
"type": "progene_text",
"text": [
"beta-secretase"
],
"offsets": [
[
72,
86
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2222 | split_0_train_2222 | [
{
"id": "split_0_train_2222_passage",
"type": "progene_text",
"text": [
"In addition , lipophilic sidechains have been incorporated and a crystal structure of such an octapeptidic inhibitor bound in the active site is already available ."
],
"offsets": [
[
0,
164
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2223 | split_0_train_2223 | [
{
"id": "split_0_train_2223_passage",
"type": "progene_text",
"text": [
"Recent progress in the field of BACE inhibition is reviewed ."
],
"offsets": [
[
0,
61
]
]
}
]
| [
{
"id": "split_0_train_3294_entity",
"type": "progene_text",
"text": [
"BACE"
],
"offsets": [
[
32,
36
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2224 | split_0_train_2224 | [
{
"id": "split_0_train_2224_passage",
"type": "progene_text",
"text": [
"A novel asparaginase - like protein is a sperm autoantigen in rats ."
],
"offsets": [
[
0,
68
]
]
}
]
| [
{
"id": "split_0_train_3295_entity",
"type": "progene_text",
"text": [
"asparaginase - like protein"
],
"offsets": [
[
8,
35
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2225 | split_0_train_2225 | [
{
"id": "split_0_train_2225_passage",
"type": "progene_text",
"text": [
"A novel asparaginase - like protein ( ALP ) of spermatozoa was cloned from rat and human testis cDNA libraries on the basis of reactivity with antibodies produced after vasectomy ."
],
"offsets": [
[
0,
180
]
]
}
]
| [
{
"id": "split_0_train_3296_entity",
"type": "progene_text",
"text": [
"asparaginase - like protein"
],
"offsets": [
[
8,
35
]
],
"normalized": []
},
{
"id": "split_0_train_3297_entity",
"type": "progene_text",
"text": [
"ALP"
],
"offsets": [
[
38,
41
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2226 | split_0_train_2226 | [
{
"id": "split_0_train_2226_passage",
"type": "progene_text",
"text": [
"Although obstruction of the male reproductive tract is known to cause an immunologic response , few of the sperm antigens responsible for the generation of autoantibodies have been characterized ."
],
"offsets": [
[
0,
196
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2227 | split_0_train_2227 | [
{
"id": "split_0_train_2227_passage",
"type": "progene_text",
"text": [
"We are identifying proteins of interest by coring autoantigenic protein spots from two - dimensional ( 2-D ) gels of rat sperm extracts and microsequencing them by mass spectrometry ."
],
"offsets": [
[
0,
183
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2228 | split_0_train_2228 | [
{
"id": "split_0_train_2228_passage",
"type": "progene_text",
"text": [
"The peptide sequences from ALP , a 28 kDa , pI 5.7 protein , matched to a single partial length rat EST ."
],
"offsets": [
[
0,
105
]
]
}
]
| [
{
"id": "split_0_train_3298_entity",
"type": "progene_text",
"text": [
"ALP"
],
"offsets": [
[
27,
30
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2229 | split_0_train_2229 | [
{
"id": "split_0_train_2229_passage",
"type": "progene_text",
"text": [
"These peptide sequences were used to clone a cDNA encoding a novel 333 amino acid open reading frame ."
],
"offsets": [
[
0,
102
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2230 | split_0_train_2230 | [
{
"id": "split_0_train_2230_passage",
"type": "progene_text",
"text": [
"The new protein had a similarity to portions of L-asparaginases of plants ( 43 % ) and to glycosylasparaginases in animal cells ( 32 % ) ."
],
"offsets": [
[
0,
138
]
]
}
]
| [
{
"id": "split_0_train_3299_entity",
"type": "progene_text",
"text": [
"L-asparaginases"
],
"offsets": [
[
48,
63
]
],
"normalized": []
},
{
"id": "split_0_train_3300_entity",
"type": "progene_text",
"text": [
"glycosylasparaginases"
],
"offsets": [
[
90,
111
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2231 | split_0_train_2231 | [
{
"id": "split_0_train_2231_passage",
"type": "progene_text",
"text": [
"Human ALP cDNA was subsequently cloned ."
],
"offsets": [
[
0,
40
]
]
}
]
| [
{
"id": "split_0_train_3301_entity",
"type": "progene_text",
"text": [
"ALP"
],
"offsets": [
[
6,
9
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2232 | split_0_train_2232 | [
{
"id": "split_0_train_2232_passage",
"type": "progene_text",
"text": [
"It showed 77 % identity to the rat ALP sequence and the gene , ASRGL1 ( asparaginase - like 1 ) , mapped to chromosome locus 11q12.3 ."
],
"offsets": [
[
0,
134
]
]
}
]
| [
{
"id": "split_0_train_3302_entity",
"type": "progene_text",
"text": [
"ALP"
],
"offsets": [
[
35,
38
]
],
"normalized": []
},
{
"id": "split_0_train_3303_entity",
"type": "progene_text",
"text": [
"ASRGL1"
],
"offsets": [
[
63,
69
]
],
"normalized": []
},
{
"id": "split_0_train_3304_entity",
"type": "progene_text",
"text": [
"asparaginase - like 1"
],
"offsets": [
[
72,
93
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2233 | split_0_train_2233 | [
{
"id": "split_0_train_2233_passage",
"type": "progene_text",
"text": [
"Purified recombinant rat ALP ( rALP ) , expressed in E. coli , was used to raise polyclonal antiserum in guinea pigs ."
],
"offsets": [
[
0,
118
]
]
}
]
| [
{
"id": "split_0_train_3305_entity",
"type": "progene_text",
"text": [
"ALP"
],
"offsets": [
[
25,
28
]
],
"normalized": []
},
{
"id": "split_0_train_3306_entity",
"type": "progene_text",
"text": [
"rALP"
],
"offsets": [
[
31,
35
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2234 | split_0_train_2234 | [
{
"id": "split_0_train_2234_passage",
"type": "progene_text",
"text": [
"Two observations verified that the correct protein had been cloned : 1 ) the anti - rALP antibody reacted with both rALP and rat sperm ; and 2 ) post - vasectomy sera bound rALP ."
],
"offsets": [
[
0,
179
]
]
}
]
| [
{
"id": "split_0_train_3307_entity",
"type": "progene_text",
"text": [
"rALP"
],
"offsets": [
[
84,
88
]
],
"normalized": []
},
{
"id": "split_0_train_3308_entity",
"type": "progene_text",
"text": [
"rALP"
],
"offsets": [
[
116,
120
]
],
"normalized": []
},
{
"id": "split_0_train_3309_entity",
"type": "progene_text",
"text": [
"rALP"
],
"offsets": [
[
173,
177
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2235 | split_0_train_2235 | [
{
"id": "split_0_train_2235_passage",
"type": "progene_text",
"text": [
"Anti - rALP antibody stained the midpiece of rat and human sperm coincident with staining by MitoTracker Green FM , suggesting that ALP is associated with the mitochondria ."
],
"offsets": [
[
0,
173
]
]
}
]
| [
{
"id": "split_0_train_3310_entity",
"type": "progene_text",
"text": [
"rALP"
],
"offsets": [
[
7,
11
]
],
"normalized": []
},
{
"id": "split_0_train_3311_entity",
"type": "progene_text",
"text": [
"ALP"
],
"offsets": [
[
132,
135
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2236 | split_0_train_2236 | [
{
"id": "split_0_train_2236_passage",
"type": "progene_text",
"text": [
"Northern analysis revealed that rat ALP message was abundantly expressed in the testis but was also present in heart , brain , liver , skeletal muscle , and kidney ."
],
"offsets": [
[
0,
165
]
]
}
]
| [
{
"id": "split_0_train_3312_entity",
"type": "progene_text",
"text": [
"ALP"
],
"offsets": [
[
36,
39
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2237 | split_0_train_2237 | [
{
"id": "split_0_train_2237_passage",
"type": "progene_text",
"text": [
"The XAGE family of cancer / testis - associated genes : alignment and expression profile in normal tissues , melanoma lesions and Ewing 's sarcoma ."
],
"offsets": [
[
0,
148
]
]
}
]
| [
{
"id": "split_0_train_3313_entity",
"type": "progene_text",
"text": [
"XAGE family"
],
"offsets": [
[
4,
15
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2238 | split_0_train_2238 | [
{
"id": "split_0_train_2238_passage",
"type": "progene_text",
"text": [
"The existence of XAGE genes was first reported after database homology searches for PAGE - like sequences identified 3 XAGE EST clusters ."
],
"offsets": [
[
0,
138
]
]
}
]
| [
{
"id": "split_0_train_3314_entity",
"type": "progene_text",
"text": [
"XAGE"
],
"offsets": [
[
17,
21
]
],
"normalized": []
},
{
"id": "split_0_train_3315_entity",
"type": "progene_text",
"text": [
"XAGE"
],
"offsets": [
[
119,
123
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2239 | split_0_train_2239 | [
{
"id": "split_0_train_2239_passage",
"type": "progene_text",
"text": [
"One of these clusters , XAGE-1 , has in later studies been identified as a cancer / testis - associated gene ."
],
"offsets": [
[
0,
110
]
]
}
]
| [
{
"id": "split_0_train_3316_entity",
"type": "progene_text",
"text": [
"XAGE-1"
],
"offsets": [
[
24,
30
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2240 | split_0_train_2240 | [
{
"id": "split_0_train_2240_passage",
"type": "progene_text",
"text": [
"Here , we report the expression profiles of all 3 reported XAGE genes , as well as several splice variants of XAGE-1 , in normal human tissues , Ewing 's sarcoma and melanocytic tumors ."
],
"offsets": [
[
0,
186
]
]
}
]
| [
{
"id": "split_0_train_3317_entity",
"type": "progene_text",
"text": [
"XAGE"
],
"offsets": [
[
59,
63
]
],
"normalized": []
},
{
"id": "split_0_train_3318_entity",
"type": "progene_text",
"text": [
"XAGE-1"
],
"offsets": [
[
110,
116
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2241 | split_0_train_2241 | [
{
"id": "split_0_train_2241_passage",
"type": "progene_text",
"text": [
"We also provide the genetic structure of the corresponding genes ."
],
"offsets": [
[
0,
66
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2242 | split_0_train_2242 | [
{
"id": "split_0_train_2242_passage",
"type": "progene_text",
"text": [
"Moreover , by searching the databases for XAGE homologues , we identified 3 additional GAGE - like genes ."
],
"offsets": [
[
0,
106
]
]
}
]
| [
{
"id": "split_0_train_3319_entity",
"type": "progene_text",
"text": [
"XAGE"
],
"offsets": [
[
42,
46
]
],
"normalized": []
},
{
"id": "split_0_train_3320_entity",
"type": "progene_text",
"text": [
"GAGE"
],
"offsets": [
[
87,
91
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2243 | split_0_train_2243 | [
{
"id": "split_0_train_2243_passage",
"type": "progene_text",
"text": [
"RT - PCR studies showed frequent expression in melanoma metastases and Ewing 's sarcoma for 2 XAGE-1 - derived transcripts ."
],
"offsets": [
[
0,
124
]
]
}
]
| [
{
"id": "split_0_train_3321_entity",
"type": "progene_text",
"text": [
"XAGE-1"
],
"offsets": [
[
94,
100
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2244 | split_0_train_2244 | [
{
"id": "split_0_train_2244_passage",
"type": "progene_text",
"text": [
"XAGE-2 was expressed at lower frequency in these tissues , while XAGE-3 was seen only in normal placenta ."
],
"offsets": [
[
0,
106
]
]
}
]
| [
{
"id": "split_0_train_3322_entity",
"type": "progene_text",
"text": [
"XAGE-2"
],
"offsets": [
[
0,
6
]
],
"normalized": []
},
{
"id": "split_0_train_3323_entity",
"type": "progene_text",
"text": [
"XAGE-3"
],
"offsets": [
[
65,
71
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2245 | split_0_train_2245 | [
{
"id": "split_0_train_2245_passage",
"type": "progene_text",
"text": [
"Due to a frameshift , the largest XAGE-1 putative protein is far less homologous to GAGE - like proteins than the other XAGEs ."
],
"offsets": [
[
0,
127
]
]
}
]
| [
{
"id": "split_0_train_3324_entity",
"type": "progene_text",
"text": [
"XAGE-1"
],
"offsets": [
[
34,
40
]
],
"normalized": []
},
{
"id": "split_0_train_3325_entity",
"type": "progene_text",
"text": [
"GAGE"
],
"offsets": [
[
84,
88
]
],
"normalized": []
},
{
"id": "split_0_train_3326_entity",
"type": "progene_text",
"text": [
"XAGEs"
],
"offsets": [
[
120,
125
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2246 | split_0_train_2246 | [
{
"id": "split_0_train_2246_passage",
"type": "progene_text",
"text": [
"Interestingly , all GAGE - like genes contain a large secondary open reading frame , coding for putative proteins homologues to the XAGE-1 primary protein ."
],
"offsets": [
[
0,
156
]
]
}
]
| [
{
"id": "split_0_train_3327_entity",
"type": "progene_text",
"text": [
"GAGE"
],
"offsets": [
[
20,
24
]
],
"normalized": []
},
{
"id": "split_0_train_3328_entity",
"type": "progene_text",
"text": [
"XAGE-1"
],
"offsets": [
[
132,
138
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2247 | split_0_train_2247 | [
{
"id": "split_0_train_2247_passage",
"type": "progene_text",
"text": [
"The XAGE family of cancer / testis - associated genes is located on chromosome Xp11.21 - Xp11.22 ."
],
"offsets": [
[
0,
98
]
]
}
]
| [
{
"id": "split_0_train_3329_entity",
"type": "progene_text",
"text": [
"XAGE family"
],
"offsets": [
[
4,
15
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2248 | split_0_train_2248 | [
{
"id": "split_0_train_2248_passage",
"type": "progene_text",
"text": [
"The data outline a superfamily of GAGE - like cancer / testis antigens , consisting of at least 19 genes ."
],
"offsets": [
[
0,
106
]
]
}
]
| [
{
"id": "split_0_train_3330_entity",
"type": "progene_text",
"text": [
"superfamily of GAGE - like cancer / testis antigens"
],
"offsets": [
[
19,
70
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2249 | split_0_train_2249 | [
{
"id": "split_0_train_2249_passage",
"type": "progene_text",
"text": [
"Novel intercellular communication system in Escherichia coli that confers antibiotic resistance between physically separated populations ."
],
"offsets": [
[
0,
138
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2250 | split_0_train_2250 | [
{
"id": "split_0_train_2250_passage",
"type": "progene_text",
"text": [
"AIMS :"
],
"offsets": [
[
0,
6
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2251 | split_0_train_2251 | [
{
"id": "split_0_train_2251_passage",
"type": "progene_text",
"text": [
"To determine whether intercellular signalling can occur between physically separated populations of Escherichia coli ."
],
"offsets": [
[
0,
118
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2252 | split_0_train_2252 | [
{
"id": "split_0_train_2252_passage",
"type": "progene_text",
"text": [
"METHODS AND RESULTS :"
],
"offsets": [
[
0,
21
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2253 | split_0_train_2253 | [
{
"id": "split_0_train_2253_passage",
"type": "progene_text",
"text": [
"Intercellular signalling between physically discrete populations of E. coli BL21 was analysed in bi - partite Petri dishes ."
],
"offsets": [
[
0,
124
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2254 | split_0_train_2254 | [
{
"id": "split_0_train_2254_passage",
"type": "progene_text",
"text": [
"Transfer of a growth - promoting signal resulted in induction of resistance to the antibiotic ampicillin ."
],
"offsets": [
[
0,
106
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2255 | split_0_train_2255 | [
{
"id": "split_0_train_2255_passage",
"type": "progene_text",
"text": [
"Optimal expression of the signal occurred when the signalling population was established as a bacterial lawn for 24 h ."
],
"offsets": [
[
0,
119
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2256 | split_0_train_2256 | [
{
"id": "split_0_train_2256_passage",
"type": "progene_text",
"text": [
"This represented an entry into the stationary phase of growth , as indicated by the expression profile of the RNA polymerase subunit sigma38 ( sigmaS ; sigma S ) ."
],
"offsets": [
[
0,
163
]
]
}
]
| [
{
"id": "split_0_train_3331_entity",
"type": "progene_text",
"text": [
"RNA polymerase subunit sigma38"
],
"offsets": [
[
110,
140
]
],
"normalized": []
},
{
"id": "split_0_train_3332_entity",
"type": "progene_text",
"text": [
"sigmaS"
],
"offsets": [
[
143,
149
]
],
"normalized": []
},
{
"id": "split_0_train_3333_entity",
"type": "progene_text",
"text": [
"sigma S"
],
"offsets": [
[
152,
159
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2257 | split_0_train_2257 | [
{
"id": "split_0_train_2257_passage",
"type": "progene_text",
"text": [
"The growth - promoting effect was also observed when E. coli DH5alpha ( luxS - ) was used as the signalling population ."
],
"offsets": [
[
0,
120
]
]
}
]
| [
{
"id": "split_0_train_3334_entity",
"type": "progene_text",
"text": [
"luxS"
],
"offsets": [
[
72,
76
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2258 | split_0_train_2258 | [
{
"id": "split_0_train_2258_passage",
"type": "progene_text",
"text": [
"Preventing passage of air between the two populations resulted in a complete cessation of the growth - promoting effect ."
],
"offsets": [
[
0,
121
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2259 | split_0_train_2259 | [
{
"id": "split_0_train_2259_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2260 | split_0_train_2260 | [
{
"id": "split_0_train_2260_passage",
"type": "progene_text",
"text": [
"A growth - promoting signal occurs between physically separated cultures of E. coli ."
],
"offsets": [
[
0,
85
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2261 | split_0_train_2261 | [
{
"id": "split_0_train_2261_passage",
"type": "progene_text",
"text": [
"The exact nature of the signal remains to be determined but does not involve the production of autoinducer-2 from the luxS gene ."
],
"offsets": [
[
0,
129
]
]
}
]
| [
{
"id": "split_0_train_3335_entity",
"type": "progene_text",
"text": [
"luxS"
],
"offsets": [
[
118,
122
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2262 | split_0_train_2262 | [
{
"id": "split_0_train_2262_passage",
"type": "progene_text",
"text": [
"Signal transmission is likely to involve airborne transfer of a signal species ."
],
"offsets": [
[
0,
80
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2263 | split_0_train_2263 | [
{
"id": "split_0_train_2263_passage",
"type": "progene_text",
"text": [
"SIGNIFICANCE AND IMPACT OF THE STUDY :"
],
"offsets": [
[
0,
38
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2264 | split_0_train_2264 | [
{
"id": "split_0_train_2264_passage",
"type": "progene_text",
"text": [
"Intercellular signalling systems exist in bacteria that enable antibiotic resistance to be conferred between physically separated populations ."
],
"offsets": [
[
0,
143
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2265 | split_0_train_2265 | [
{
"id": "split_0_train_2265_passage",
"type": "progene_text",
"text": [
"PYPAF7 , a novel PYRIN - containing Apaf1 - like protein that regulates activation of NF-kappa B and caspase-1 - dependent cytokine processing ."
],
"offsets": [
[
0,
144
]
]
}
]
| [
{
"id": "split_0_train_3336_entity",
"type": "progene_text",
"text": [
"PYPAF7"
],
"offsets": [
[
0,
6
]
],
"normalized": []
},
{
"id": "split_0_train_3337_entity",
"type": "progene_text",
"text": [
"PYRIN - containing Apaf1 - like protein"
],
"offsets": [
[
17,
56
]
],
"normalized": []
},
{
"id": "split_0_train_3338_entity",
"type": "progene_text",
"text": [
"NF-kappa B"
],
"offsets": [
[
86,
96
]
],
"normalized": []
},
{
"id": "split_0_train_3339_entity",
"type": "progene_text",
"text": [
"caspase-1"
],
"offsets": [
[
101,
110
]
],
"normalized": []
},
{
"id": "split_0_train_3340_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
123,
131
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2266 | split_0_train_2266 | [
{
"id": "split_0_train_2266_passage",
"type": "progene_text",
"text": [
"PYRIN - containing Apaf1 - like proteins ( PYPAFs ) are members of the nucleotide - binding site / leucine - rich repeat ( NBS / LRR ) family of signal transduction proteins ."
],
"offsets": [
[
0,
175
]
]
}
]
| [
{
"id": "split_0_train_3341_entity",
"type": "progene_text",
"text": [
"PYRIN - containing Apaf1 - like proteins"
],
"offsets": [
[
0,
40
]
],
"normalized": []
},
{
"id": "split_0_train_3342_entity",
"type": "progene_text",
"text": [
"PYPAFs"
],
"offsets": [
[
43,
49
]
],
"normalized": []
},
{
"id": "split_0_train_3343_entity",
"type": "progene_text",
"text": [
"nucleotide - binding site / leucine - rich repeat ( NBS / LRR ) family"
],
"offsets": [
[
71,
141
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2267 | split_0_train_2267 | [
{
"id": "split_0_train_2267_passage",
"type": "progene_text",
"text": [
"We report here that PYPAF7 is a novel PYPAF protein that activates inflammatory signaling pathways ."
],
"offsets": [
[
0,
100
]
]
}
]
| [
{
"id": "split_0_train_3344_entity",
"type": "progene_text",
"text": [
"PYPAF7"
],
"offsets": [
[
20,
26
]
],
"normalized": []
},
{
"id": "split_0_train_3345_entity",
"type": "progene_text",
"text": [
"PYPAF"
],
"offsets": [
[
38,
43
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2268 | split_0_train_2268 | [
{
"id": "split_0_train_2268_passage",
"type": "progene_text",
"text": [
"The expression of PYPAF7 is highly restricted to immune cells , and its gene maps to chromosome 19q13.4 , a locus that contains a cluster of genes encoding numerous PYPAF family members ."
],
"offsets": [
[
0,
187
]
]
}
]
| [
{
"id": "split_0_train_3346_entity",
"type": "progene_text",
"text": [
"PYPAF7"
],
"offsets": [
[
18,
24
]
],
"normalized": []
},
{
"id": "split_0_train_3347_entity",
"type": "progene_text",
"text": [
"PYPAF family"
],
"offsets": [
[
165,
177
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2269 | split_0_train_2269 | [
{
"id": "split_0_train_2269_passage",
"type": "progene_text",
"text": [
"Co - expression of PYPAF7 with ASC results in the recruitment of PYPAF7 to distinct cytoplasmic loci and a potent synergistic activation of NF-kappa B ."
],
"offsets": [
[
0,
152
]
]
}
]
| [
{
"id": "split_0_train_3348_entity",
"type": "progene_text",
"text": [
"PYPAF7"
],
"offsets": [
[
19,
25
]
],
"normalized": []
},
{
"id": "split_0_train_3349_entity",
"type": "progene_text",
"text": [
"ASC"
],
"offsets": [
[
31,
34
]
],
"normalized": []
},
{
"id": "split_0_train_3350_entity",
"type": "progene_text",
"text": [
"PYPAF7"
],
"offsets": [
[
65,
71
]
],
"normalized": []
},
{
"id": "split_0_train_3351_entity",
"type": "progene_text",
"text": [
"NF-kappa B"
],
"offsets": [
[
140,
150
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2270 | split_0_train_2270 | [
{
"id": "split_0_train_2270_passage",
"type": "progene_text",
"text": [
"To identify other proteins involved in PYPAF7 and ASC signaling pathways , we performed a mammalian two - hybrid screen and identified pro - caspase-1 as a binding partner of ASC ."
],
"offsets": [
[
0,
180
]
]
}
]
| [
{
"id": "split_0_train_3352_entity",
"type": "progene_text",
"text": [
"PYPAF7"
],
"offsets": [
[
39,
45
]
],
"normalized": []
},
{
"id": "split_0_train_3353_entity",
"type": "progene_text",
"text": [
"ASC"
],
"offsets": [
[
50,
53
]
],
"normalized": []
},
{
"id": "split_0_train_3354_entity",
"type": "progene_text",
"text": [
"caspase-1"
],
"offsets": [
[
141,
150
]
],
"normalized": []
},
{
"id": "split_0_train_3355_entity",
"type": "progene_text",
"text": [
"ASC"
],
"offsets": [
[
175,
178
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2271 | split_0_train_2271 | [
{
"id": "split_0_train_2271_passage",
"type": "progene_text",
"text": [
"Co - expression of PYPAF7 and ASC results in the synergistic activation of caspase-1 and a corresponding increase in secretion of interleukin-1 beta ."
],
"offsets": [
[
0,
150
]
]
}
]
| [
{
"id": "split_0_train_3356_entity",
"type": "progene_text",
"text": [
"PYPAF7"
],
"offsets": [
[
19,
25
]
],
"normalized": []
},
{
"id": "split_0_train_3357_entity",
"type": "progene_text",
"text": [
"ASC"
],
"offsets": [
[
30,
33
]
],
"normalized": []
},
{
"id": "split_0_train_3358_entity",
"type": "progene_text",
"text": [
"caspase-1"
],
"offsets": [
[
75,
84
]
],
"normalized": []
},
{
"id": "split_0_train_3359_entity",
"type": "progene_text",
"text": [
"interleukin-1 beta"
],
"offsets": [
[
130,
148
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2272 | split_0_train_2272 | [
{
"id": "split_0_train_2272_passage",
"type": "progene_text",
"text": [
"In addition , PYPAF1 induces caspase-1 - dependent cytokine processing when co - expressed with ASC ."
],
"offsets": [
[
0,
101
]
]
}
]
| [
{
"id": "split_0_train_3360_entity",
"type": "progene_text",
"text": [
"PYPAF1"
],
"offsets": [
[
14,
20
]
],
"normalized": []
},
{
"id": "split_0_train_3361_entity",
"type": "progene_text",
"text": [
"caspase-1"
],
"offsets": [
[
29,
38
]
],
"normalized": []
},
{
"id": "split_0_train_3362_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
51,
59
]
],
"normalized": []
},
{
"id": "split_0_train_3363_entity",
"type": "progene_text",
"text": [
"ASC"
],
"offsets": [
[
96,
99
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2273 | split_0_train_2273 | [
{
"id": "split_0_train_2273_passage",
"type": "progene_text",
"text": [
"These findings indicate that PYPAF family members participate in inflammatory signaling by regulating the activation of NF-kappa B and cytokine processing ."
],
"offsets": [
[
0,
156
]
]
}
]
| [
{
"id": "split_0_train_3364_entity",
"type": "progene_text",
"text": [
"PYPAF family"
],
"offsets": [
[
29,
41
]
],
"normalized": []
},
{
"id": "split_0_train_3365_entity",
"type": "progene_text",
"text": [
"NF-kappa B"
],
"offsets": [
[
120,
130
]
],
"normalized": []
},
{
"id": "split_0_train_3366_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
135,
143
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2274 | split_0_train_2274 | [
{
"id": "split_0_train_2274_passage",
"type": "progene_text",
"text": [
"Metallochaperone Atox1 transfers copper to the NH2 - terminal domain of the Wilson 's disease protein and regulates its catalytic activity ."
],
"offsets": [
[
0,
140
]
]
}
]
| [
{
"id": "split_0_train_3367_entity",
"type": "progene_text",
"text": [
"Metallochaperone"
],
"offsets": [
[
0,
16
]
],
"normalized": []
},
{
"id": "split_0_train_3368_entity",
"type": "progene_text",
"text": [
"Atox1"
],
"offsets": [
[
17,
22
]
],
"normalized": []
},
{
"id": "split_0_train_3369_entity",
"type": "progene_text",
"text": [
"Wilson 's disease protein"
],
"offsets": [
[
76,
101
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2275 | split_0_train_2275 | [
{
"id": "split_0_train_2275_passage",
"type": "progene_text",
"text": [
"Copper is essential for the growth and development of mammalian cells ."
],
"offsets": [
[
0,
71
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2276 | split_0_train_2276 | [
{
"id": "split_0_train_2276_passage",
"type": "progene_text",
"text": [
"The key role in the intracellular distribution of copper belongs to the recently discovered family of metallochaperones and to copper - transporting P - type ATPases ."
],
"offsets": [
[
0,
167
]
]
}
]
| [
{
"id": "split_0_train_3370_entity",
"type": "progene_text",
"text": [
"metallochaperones"
],
"offsets": [
[
102,
119
]
],
"normalized": []
},
{
"id": "split_0_train_3371_entity",
"type": "progene_text",
"text": [
"copper - transporting P - type ATPases"
],
"offsets": [
[
127,
165
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2277 | split_0_train_2277 | [
{
"id": "split_0_train_2277_passage",
"type": "progene_text",
"text": [
"The mutations in the ATPase ATP7B , the Wilson 's disease protein ( WNDP ) , lead to intracellular accumulation of copper and severe hepatic and neurological abnormalities ."
],
"offsets": [
[
0,
173
]
]
}
]
| [
{
"id": "split_0_train_3372_entity",
"type": "progene_text",
"text": [
"ATPase"
],
"offsets": [
[
21,
27
]
],
"normalized": []
},
{
"id": "split_0_train_3373_entity",
"type": "progene_text",
"text": [
"ATP7B"
],
"offsets": [
[
28,
33
]
],
"normalized": []
},
{
"id": "split_0_train_3374_entity",
"type": "progene_text",
"text": [
"Wilson 's disease protein"
],
"offsets": [
[
40,
65
]
],
"normalized": []
},
{
"id": "split_0_train_3375_entity",
"type": "progene_text",
"text": [
"WNDP"
],
"offsets": [
[
68,
72
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2278 | split_0_train_2278 | [
{
"id": "split_0_train_2278_passage",
"type": "progene_text",
"text": [
"Several of these mutations were shown to disrupt the protein - protein interactions between WNDP and the metallochaperone Atox1 , suggesting that these interactions are important for normal copper homeostasis ."
],
"offsets": [
[
0,
210
]
]
}
]
| [
{
"id": "split_0_train_3376_entity",
"type": "progene_text",
"text": [
"WNDP"
],
"offsets": [
[
92,
96
]
],
"normalized": []
},
{
"id": "split_0_train_3377_entity",
"type": "progene_text",
"text": [
"metallochaperone"
],
"offsets": [
[
105,
121
]
],
"normalized": []
},
{
"id": "split_0_train_3378_entity",
"type": "progene_text",
"text": [
"Atox1"
],
"offsets": [
[
122,
127
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2279 | split_0_train_2279 | [
{
"id": "split_0_train_2279_passage",
"type": "progene_text",
"text": [
"To understand the functional consequences of the Atox1 - WNDP interaction at the molecular level , we produced recombinant Atox1 and characterized its effects on WNDP ."
],
"offsets": [
[
0,
168
]
]
}
]
| [
{
"id": "split_0_train_3379_entity",
"type": "progene_text",
"text": [
"Atox1"
],
"offsets": [
[
49,
54
]
],
"normalized": []
},
{
"id": "split_0_train_3380_entity",
"type": "progene_text",
"text": [
"WNDP"
],
"offsets": [
[
57,
61
]
],
"normalized": []
},
{
"id": "split_0_train_3381_entity",
"type": "progene_text",
"text": [
"Atox1"
],
"offsets": [
[
123,
128
]
],
"normalized": []
},
{
"id": "split_0_train_3382_entity",
"type": "progene_text",
"text": [
"WNDP"
],
"offsets": [
[
162,
166
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2280 | split_0_train_2280 | [
{
"id": "split_0_train_2280_passage",
"type": "progene_text",
"text": [
"We demonstrate that Atox1 transfers copper to the purified amino - terminal domain of WNDP ( N - WNDP ) in a dose - dependent and saturable manner ."
],
"offsets": [
[
0,
148
]
]
}
]
| [
{
"id": "split_0_train_3383_entity",
"type": "progene_text",
"text": [
"Atox1"
],
"offsets": [
[
20,
25
]
],
"normalized": []
},
{
"id": "split_0_train_3384_entity",
"type": "progene_text",
"text": [
"WNDP"
],
"offsets": [
[
86,
90
]
],
"normalized": []
},
{
"id": "split_0_train_3385_entity",
"type": "progene_text",
"text": [
"WNDP"
],
"offsets": [
[
97,
101
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2281 | split_0_train_2281 | [
{
"id": "split_0_train_2281_passage",
"type": "progene_text",
"text": [
"A maximum of six copper atoms can be transferred to N - WNDP by the chaperone ."
],
"offsets": [
[
0,
79
]
]
}
]
| [
{
"id": "split_0_train_3386_entity",
"type": "progene_text",
"text": [
"WNDP"
],
"offsets": [
[
56,
60
]
],
"normalized": []
},
{
"id": "split_0_train_3387_entity",
"type": "progene_text",
"text": [
"chaperone"
],
"offsets": [
[
68,
77
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2282 | split_0_train_2282 | [
{
"id": "split_0_train_2282_passage",
"type": "progene_text",
"text": [
"Furthermore , the incubation of copper Atox1 with the full - length WNDP leads to the stimulation of the WNDP catalytic activity , providing strong evidence for the direct effect of Atox1 on the function of this transporter ."
],
"offsets": [
[
0,
225
]
]
}
]
| [
{
"id": "split_0_train_3388_entity",
"type": "progene_text",
"text": [
"Atox1"
],
"offsets": [
[
39,
44
]
],
"normalized": []
},
{
"id": "split_0_train_3389_entity",
"type": "progene_text",
"text": [
"WNDP"
],
"offsets": [
[
68,
72
]
],
"normalized": []
},
{
"id": "split_0_train_3390_entity",
"type": "progene_text",
"text": [
"WNDP"
],
"offsets": [
[
105,
109
]
],
"normalized": []
},
{
"id": "split_0_train_3391_entity",
"type": "progene_text",
"text": [
"Atox1"
],
"offsets": [
[
182,
187
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2283 | split_0_train_2283 | [
{
"id": "split_0_train_2283_passage",
"type": "progene_text",
"text": [
"Our data also suggest that Atox1 can regulate the copper occupancy of WNDP ."
],
"offsets": [
[
0,
76
]
]
}
]
| [
{
"id": "split_0_train_3392_entity",
"type": "progene_text",
"text": [
"Atox1"
],
"offsets": [
[
27,
32
]
],
"normalized": []
},
{
"id": "split_0_train_3393_entity",
"type": "progene_text",
"text": [
"WNDP"
],
"offsets": [
[
70,
74
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2284 | split_0_train_2284 | [
{
"id": "split_0_train_2284_passage",
"type": "progene_text",
"text": [
"The incubation with apo - Atox1 results in the removal of copper from the metalated N - WNDP and apparent down - regulation of WNDP activity ."
],
"offsets": [
[
0,
142
]
]
}
]
| [
{
"id": "split_0_train_3394_entity",
"type": "progene_text",
"text": [
"Atox1"
],
"offsets": [
[
26,
31
]
],
"normalized": []
},
{
"id": "split_0_train_3395_entity",
"type": "progene_text",
"text": [
"WNDP"
],
"offsets": [
[
88,
92
]
],
"normalized": []
},
{
"id": "split_0_train_3396_entity",
"type": "progene_text",
"text": [
"WNDP"
],
"offsets": [
[
127,
131
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2285 | split_0_train_2285 | [
{
"id": "split_0_train_2285_passage",
"type": "progene_text",
"text": [
"Interestingly , at least one copper atom remains tightly bound to N - WNDP even in the presence of excess apo - Atox1 ."
],
"offsets": [
[
0,
119
]
]
}
]
| [
{
"id": "split_0_train_3397_entity",
"type": "progene_text",
"text": [
"WNDP"
],
"offsets": [
[
70,
74
]
],
"normalized": []
},
{
"id": "split_0_train_3398_entity",
"type": "progene_text",
"text": [
"Atox1"
],
"offsets": [
[
112,
117
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2286 | split_0_train_2286 | [
{
"id": "split_0_train_2286_passage",
"type": "progene_text",
"text": [
"We suggest that this incomplete reversibility reflects the functional non - equivalency of the metal - binding sites in WNDP and speculate about the intracellular consequences of the reversible Atox1 - mediated copper transfer ."
],
"offsets": [
[
0,
228
]
]
}
]
| [
{
"id": "split_0_train_3399_entity",
"type": "progene_text",
"text": [
"WNDP"
],
"offsets": [
[
120,
124
]
],
"normalized": []
},
{
"id": "split_0_train_3400_entity",
"type": "progene_text",
"text": [
"Atox1"
],
"offsets": [
[
194,
199
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2287 | split_0_train_2287 | [
{
"id": "split_0_train_2287_passage",
"type": "progene_text",
"text": [
"Significance of the parkin gene and protein in understanding Parkinson 's disease ."
],
"offsets": [
[
0,
83
]
]
}
]
| [
{
"id": "split_0_train_3401_entity",
"type": "progene_text",
"text": [
"parkin"
],
"offsets": [
[
20,
26
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2288 | split_0_train_2288 | [
{
"id": "split_0_train_2288_passage",
"type": "progene_text",
"text": [
"Mutations in the parkin gene cause autosomal recessive inherited juvenile parkinsonism ( ARJP ) and account for the majority of cases of inherited Parkinson 's disease ( PD ) of young onset ( < 45 years of age ) ."
],
"offsets": [
[
0,
213
]
]
}
]
| [
{
"id": "split_0_train_3402_entity",
"type": "progene_text",
"text": [
"parkin"
],
"offsets": [
[
17,
23
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2289 | split_0_train_2289 | [
{
"id": "split_0_train_2289_passage",
"type": "progene_text",
"text": [
"Patients with parkin mutations commonly have atypical clinical features such as dystonia at onset , hyper - reflexia , diurnal fluctuations , and sleep benefit ; however , parkin mutation patients with both typical PD symptoms and older age of onset have been identified ."
],
"offsets": [
[
0,
272
]
]
}
]
| [
{
"id": "split_0_train_3403_entity",
"type": "progene_text",
"text": [
"parkin"
],
"offsets": [
[
14,
20
]
],
"normalized": []
},
{
"id": "split_0_train_3404_entity",
"type": "progene_text",
"text": [
"parkin"
],
"offsets": [
[
172,
178
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2290 | split_0_train_2290 | [
{
"id": "split_0_train_2290_passage",
"type": "progene_text",
"text": [
"Parkin is a ubiquitin protein ligase ( E3 ) , a component in the pathway that attaches ubiquitin to specific proteins , designating them for degradation by the proteasome ."
],
"offsets": [
[
0,
172
]
]
}
]
| [
{
"id": "split_0_train_3405_entity",
"type": "progene_text",
"text": [
"Parkin"
],
"offsets": [
[
0,
6
]
],
"normalized": []
},
{
"id": "split_0_train_3406_entity",
"type": "progene_text",
"text": [
"ubiquitin protein ligase ( E3 )"
],
"offsets": [
[
12,
43
]
],
"normalized": []
},
{
"id": "split_0_train_3407_entity",
"type": "progene_text",
"text": [
"ubiquitin"
],
"offsets": [
[
87,
96
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2291 | split_0_train_2291 | [
{
"id": "split_0_train_2291_passage",
"type": "progene_text",
"text": [
"Several substrates for parkin have been identified ( CDCrel-1 , o - glycosylated alpha-synuclein , parkin associated endothelin - like cell receptor , and synphilin ) ."
],
"offsets": [
[
0,
168
]
]
}
]
| [
{
"id": "split_0_train_3408_entity",
"type": "progene_text",
"text": [
"parkin"
],
"offsets": [
[
23,
29
]
],
"normalized": []
},
{
"id": "split_0_train_3409_entity",
"type": "progene_text",
"text": [
"CDCrel-1"
],
"offsets": [
[
53,
61
]
],
"normalized": []
},
{
"id": "split_0_train_3410_entity",
"type": "progene_text",
"text": [
"alpha-synuclein"
],
"offsets": [
[
81,
96
]
],
"normalized": []
},
{
"id": "split_0_train_3411_entity",
"type": "progene_text",
"text": [
"parkin associated endothelin - like cell receptor"
],
"offsets": [
[
99,
148
]
],
"normalized": []
},
{
"id": "split_0_train_3412_entity",
"type": "progene_text",
"text": [
"synphilin"
],
"offsets": [
[
155,
164
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2292 | split_0_train_2292 | [
{
"id": "split_0_train_2292_passage",
"type": "progene_text",
"text": [
"The role of these substrates in the pathogenesis of ARJP is under active study ."
],
"offsets": [
[
0,
80
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2293 | split_0_train_2293 | [
{
"id": "split_0_train_2293_passage",
"type": "progene_text",
"text": [
"Most patients with parkin mutations lack Lewy bodies , suggesting that functional parkin is involved in the formation of these highly ubiquitinated inclusions ."
],
"offsets": [
[
0,
160
]
]
}
]
| [
{
"id": "split_0_train_3413_entity",
"type": "progene_text",
"text": [
"parkin"
],
"offsets": [
[
19,
25
]
],
"normalized": []
},
{
"id": "split_0_train_3414_entity",
"type": "progene_text",
"text": [
"parkin"
],
"offsets": [
[
82,
88
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2294 | split_0_train_2294 | [
{
"id": "split_0_train_2294_passage",
"type": "progene_text",
"text": [
"Furthermore , the recognition that parkin mutations can lead to a disorder clinically similar to sporadic PD , but presumably lacking Lewy bodies , calls into question the necessity of Lewy bodies for the diagnosis of PD and nigral cell death ."
],
"offsets": [
[
0,
244
]
]
}
]
| [
{
"id": "split_0_train_3415_entity",
"type": "progene_text",
"text": [
"parkin"
],
"offsets": [
[
35,
41
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2295 | split_0_train_2295 | [
{
"id": "split_0_train_2295_passage",
"type": "progene_text",
"text": [
"Studies of parkin are increasing the focus on the role of the ubiquitin - proteasome system in the pathogenesis of both familial and sporadic PD ."
],
"offsets": [
[
0,
146
]
]
}
]
| [
{
"id": "split_0_train_3416_entity",
"type": "progene_text",
"text": [
"parkin"
],
"offsets": [
[
11,
17
]
],
"normalized": []
},
{
"id": "split_0_train_3417_entity",
"type": "progene_text",
"text": [
"ubiquitin"
],
"offsets": [
[
62,
71
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2296 | split_0_train_2296 | [
{
"id": "split_0_train_2296_passage",
"type": "progene_text",
"text": [
"Phospholipase C-beta 2 interacts with mitogen - activated protein kinase kinase 3 ."
],
"offsets": [
[
0,
83
]
]
}
]
| [
{
"id": "split_0_train_3418_entity",
"type": "progene_text",
"text": [
"Phospholipase C-beta 2"
],
"offsets": [
[
0,
22
]
],
"normalized": []
},
{
"id": "split_0_train_3419_entity",
"type": "progene_text",
"text": [
"mitogen - activated protein kinase kinase 3"
],
"offsets": [
[
38,
81
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2297 | split_0_train_2297 | [
{
"id": "split_0_train_2297_passage",
"type": "progene_text",
"text": [
"Phospholipase C ( PLC ) - beta enzymes ( isoenzymes beta 1-beta 4 ) are activated by G protein subunits , leading to the generation of intracellular messengers which mobilize calcium and activate protein kinase C ."
],
"offsets": [
[
0,
214
]
]
}
]
| [
{
"id": "split_0_train_3420_entity",
"type": "progene_text",
"text": [
"Phospholipase C ( PLC ) - beta"
],
"offsets": [
[
0,
30
]
],
"normalized": []
},
{
"id": "split_0_train_3421_entity",
"type": "progene_text",
"text": [
"G protein"
],
"offsets": [
[
85,
94
]
],
"normalized": []
},
{
"id": "split_0_train_3422_entity",
"type": "progene_text",
"text": [
"protein kinase C"
],
"offsets": [
[
196,
212
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2298 | split_0_train_2298 | [
{
"id": "split_0_train_2298_passage",
"type": "progene_text",
"text": [
"It has recently been recognized that these enzymes interact with and are regulated by proteins other than G proteins ."
],
"offsets": [
[
0,
118
]
]
}
]
| [
{
"id": "split_0_train_3423_entity",
"type": "progene_text",
"text": [
"G proteins"
],
"offsets": [
[
106,
116
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2299 | split_0_train_2299 | [
{
"id": "split_0_train_2299_passage",
"type": "progene_text",
"text": [
"Using the yeast two - hybrid technique to screen a leukocyte library we identified mitogen - activated protein kinase kinase 3 ( MKK3 ) as a partner of PLC-beta 2 ."
],
"offsets": [
[
0,
164
]
]
}
]
| [
{
"id": "split_0_train_3424_entity",
"type": "progene_text",
"text": [
"mitogen - activated protein kinase kinase 3"
],
"offsets": [
[
83,
126
]
],
"normalized": []
},
{
"id": "split_0_train_3425_entity",
"type": "progene_text",
"text": [
"MKK3"
],
"offsets": [
[
129,
133
]
],
"normalized": []
},
{
"id": "split_0_train_3426_entity",
"type": "progene_text",
"text": [
"PLC-beta 2"
],
"offsets": [
[
152,
162
]
],
"normalized": []
}
]
| []
| []
| []
|
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