id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
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|---|---|---|---|---|---|---|
split_0_train_2300 | split_0_train_2300 | [
{
"id": "split_0_train_2300_passage",
"type": "progene_text",
"text": [
"The interaction was confirmed by co - immunoprecipitation assays which indicated that MKK3 interacts with PLC-beta 2 , but not with other PLC-betas ."
],
"offsets": [
[
0,
149
]
]
}
]
| [
{
"id": "split_0_train_3427_entity",
"type": "progene_text",
"text": [
"MKK3"
],
"offsets": [
[
86,
90
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],
"normalized": []
},
{
"id": "split_0_train_3428_entity",
"type": "progene_text",
"text": [
"PLC-beta 2"
],
"offsets": [
[
106,
116
]
],
"normalized": []
},
{
"id": "split_0_train_3429_entity",
"type": "progene_text",
"text": [
"PLC-betas"
],
"offsets": [
[
138,
147
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2301 | split_0_train_2301 | [
{
"id": "split_0_train_2301_passage",
"type": "progene_text",
"text": [
"PLC-beta 2 interacted weakly with MKK6 , which is related to MKK3 , but not with the other MKK3 tested ."
],
"offsets": [
[
0,
104
]
]
}
]
| [
{
"id": "split_0_train_3430_entity",
"type": "progene_text",
"text": [
"PLC-beta 2"
],
"offsets": [
[
0,
10
]
],
"normalized": []
},
{
"id": "split_0_train_3431_entity",
"type": "progene_text",
"text": [
"MKK6"
],
"offsets": [
[
34,
38
]
],
"normalized": []
},
{
"id": "split_0_train_3432_entity",
"type": "progene_text",
"text": [
"MKK3"
],
"offsets": [
[
61,
65
]
],
"normalized": []
},
{
"id": "split_0_train_3433_entity",
"type": "progene_text",
"text": [
"MKK3"
],
"offsets": [
[
91,
95
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2302 | split_0_train_2302 | [
{
"id": "split_0_train_2302_passage",
"type": "progene_text",
"text": [
"The region of PLC-beta 2 involved in the interaction with MKK3 was mapped to the C - terminus of PLC-beta 2 ."
],
"offsets": [
[
0,
109
]
]
}
]
| [
{
"id": "split_0_train_3434_entity",
"type": "progene_text",
"text": [
"PLC-beta 2"
],
"offsets": [
[
14,
24
]
],
"normalized": []
},
{
"id": "split_0_train_3435_entity",
"type": "progene_text",
"text": [
"MKK3"
],
"offsets": [
[
58,
62
]
],
"normalized": []
},
{
"id": "split_0_train_3436_entity",
"type": "progene_text",
"text": [
"PLC-beta 2"
],
"offsets": [
[
97,
107
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2303 | split_0_train_2303 | [
{
"id": "split_0_train_2303_passage",
"type": "progene_text",
"text": [
"p38MAPK also co - immunoprecipitated with PLC-beta 2 ."
],
"offsets": [
[
0,
54
]
]
}
]
| [
{
"id": "split_0_train_3437_entity",
"type": "progene_text",
"text": [
"p38MAPK"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "split_0_train_3438_entity",
"type": "progene_text",
"text": [
"PLC-beta 2"
],
"offsets": [
[
42,
52
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2304 | split_0_train_2304 | [
{
"id": "split_0_train_2304_passage",
"type": "progene_text",
"text": [
"The data suggest that PLC-beta 2 serves an unappreciated role assembling components of the p38MAPK signaling module ."
],
"offsets": [
[
0,
117
]
]
}
]
| [
{
"id": "split_0_train_3439_entity",
"type": "progene_text",
"text": [
"PLC-beta 2"
],
"offsets": [
[
22,
32
]
],
"normalized": []
},
{
"id": "split_0_train_3440_entity",
"type": "progene_text",
"text": [
"p38MAPK"
],
"offsets": [
[
91,
98
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2305 | split_0_train_2305 | [
{
"id": "split_0_train_2305_passage",
"type": "progene_text",
"text": [
"Lsm proteins are required for normal processing of pre - tRNAs and their efficient association with La - homologous protein Lhp1p ."
],
"offsets": [
[
0,
131
]
]
}
]
| [
{
"id": "split_0_train_3441_entity",
"type": "progene_text",
"text": [
"Lsm"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_3442_entity",
"type": "progene_text",
"text": [
"La"
],
"offsets": [
[
100,
102
]
],
"normalized": []
},
{
"id": "split_0_train_3443_entity",
"type": "progene_text",
"text": [
"Lhp1p"
],
"offsets": [
[
124,
129
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2306 | split_0_train_2306 | [
{
"id": "split_0_train_2306_passage",
"type": "progene_text",
"text": [
"Depletion of any of the five essential proteins Lsm2p to Lsm5p and Lsm8p leads to strong accumulation of all tested unspliced pre - tRNA species , as well as accumulation of 5' and 3' unprocessed species ."
],
"offsets": [
[
0,
205
]
]
}
]
| [
{
"id": "split_0_train_3444_entity",
"type": "progene_text",
"text": [
"Lsm2p"
],
"offsets": [
[
48,
53
]
],
"normalized": []
},
{
"id": "split_0_train_3445_entity",
"type": "progene_text",
"text": [
"Lsm5p"
],
"offsets": [
[
57,
62
]
],
"normalized": []
},
{
"id": "split_0_train_3446_entity",
"type": "progene_text",
"text": [
"Lsm8p"
],
"offsets": [
[
67,
72
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2307 | split_0_train_2307 | [
{
"id": "split_0_train_2307_passage",
"type": "progene_text",
"text": [
"Aberrant 3' - extended pre - tRNAs were detected , presumably due to stabilization of transcripts that fail to undergo correct transcription termination , and the accumulation of truncated tRNA fragments was also observed ."
],
"offsets": [
[
0,
223
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2308 | split_0_train_2308 | [
{
"id": "split_0_train_2308_passage",
"type": "progene_text",
"text": [
"Tandem affinity purification - tagged Lsm3p was associated with pre - tRNA primary transcripts and , less efficiently , with other unspliced pre - tRNA intermediates but not mature tRNAs ."
],
"offsets": [
[
0,
188
]
]
}
]
| [
{
"id": "split_0_train_3447_entity",
"type": "progene_text",
"text": [
"Lsm3p"
],
"offsets": [
[
38,
43
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2309 | split_0_train_2309 | [
{
"id": "split_0_train_2309_passage",
"type": "progene_text",
"text": [
"Association of the Saccharomyces cerevisiae La homologue Lhp1p with pre - tRNAs was reduced approximately threefold on depletion of Lsm3p or Lsm5p ."
],
"offsets": [
[
0,
148
]
]
}
]
| [
{
"id": "split_0_train_3448_entity",
"type": "progene_text",
"text": [
"La"
],
"offsets": [
[
44,
46
]
],
"normalized": []
},
{
"id": "split_0_train_3449_entity",
"type": "progene_text",
"text": [
"Lhp1p"
],
"offsets": [
[
57,
62
]
],
"normalized": []
},
{
"id": "split_0_train_3450_entity",
"type": "progene_text",
"text": [
"Lsm3p"
],
"offsets": [
[
132,
137
]
],
"normalized": []
},
{
"id": "split_0_train_3451_entity",
"type": "progene_text",
"text": [
"Lsm5p"
],
"offsets": [
[
141,
146
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2310 | split_0_train_2310 | [
{
"id": "split_0_train_2310_passage",
"type": "progene_text",
"text": [
"The association of Lhp1p with larger RNA polymerase III transcripts , pre - RNase P RNA and the signal recognition particle RNA ( scR1 ) , was more drastically reduced ."
],
"offsets": [
[
0,
169
]
]
}
]
| [
{
"id": "split_0_train_3452_entity",
"type": "progene_text",
"text": [
"Lhp1p"
],
"offsets": [
[
19,
24
]
],
"normalized": []
},
{
"id": "split_0_train_3453_entity",
"type": "progene_text",
"text": [
"RNA polymerase III"
],
"offsets": [
[
37,
55
]
],
"normalized": []
},
{
"id": "split_0_train_3454_entity",
"type": "progene_text",
"text": [
"RNase P"
],
"offsets": [
[
76,
83
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2311 | split_0_train_2311 | [
{
"id": "split_0_train_2311_passage",
"type": "progene_text",
"text": [
"The impaired pre - tRNA processing seen on Lsm depletion is not , however , due solely to reduced Lhp1p association as evidenced by analysis of lhp1 - Delta strains depleted of Lsm3p or Lsm5p ."
],
"offsets": [
[
0,
193
]
]
}
]
| [
{
"id": "split_0_train_3455_entity",
"type": "progene_text",
"text": [
"Lsm"
],
"offsets": [
[
43,
46
]
],
"normalized": []
},
{
"id": "split_0_train_3456_entity",
"type": "progene_text",
"text": [
"Lhp1p"
],
"offsets": [
[
98,
103
]
],
"normalized": []
},
{
"id": "split_0_train_3457_entity",
"type": "progene_text",
"text": [
"lhp1"
],
"offsets": [
[
144,
148
]
],
"normalized": []
},
{
"id": "split_0_train_3458_entity",
"type": "progene_text",
"text": [
"Lsm3p"
],
"offsets": [
[
177,
182
]
],
"normalized": []
},
{
"id": "split_0_train_3459_entity",
"type": "progene_text",
"text": [
"Lsm5p"
],
"offsets": [
[
186,
191
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2312 | split_0_train_2312 | [
{
"id": "split_0_train_2312_passage",
"type": "progene_text",
"text": [
"These data are consistent with roles for an Lsm complex as a chaperone that facilitates the efficient association of pre - tRNA processing factors with their substrates ."
],
"offsets": [
[
0,
170
]
]
}
]
| [
{
"id": "split_0_train_3460_entity",
"type": "progene_text",
"text": [
"Lsm"
],
"offsets": [
[
44,
47
]
],
"normalized": []
},
{
"id": "split_0_train_3461_entity",
"type": "progene_text",
"text": [
"chaperone"
],
"offsets": [
[
61,
70
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2313 | split_0_train_2313 | [
{
"id": "split_0_train_2313_passage",
"type": "progene_text",
"text": [
"Identification of human male germ cell - associated kinase , a kinase transcriptionally activated by androgen in prostate cancer cells ."
],
"offsets": [
[
0,
136
]
]
}
]
| [
{
"id": "split_0_train_3462_entity",
"type": "progene_text",
"text": [
"male germ cell - associated kinase"
],
"offsets": [
[
24,
58
]
],
"normalized": []
},
{
"id": "split_0_train_3463_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
63,
69
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2314 | split_0_train_2314 | [
{
"id": "split_0_train_2314_passage",
"type": "progene_text",
"text": [
"Androgen is involved in both normal development and malignant transformation of prostate cells ."
],
"offsets": [
[
0,
96
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2315 | split_0_train_2315 | [
{
"id": "split_0_train_2315_passage",
"type": "progene_text",
"text": [
"The signal transduction pathways associated with these processes are not well understood ."
],
"offsets": [
[
0,
90
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2316 | split_0_train_2316 | [
{
"id": "split_0_train_2316_passage",
"type": "progene_text",
"text": [
"Using a novel kinase display approach , we have identified a protein kinase , human male germ cell - associated kinase ( hMAK ) , which is transcriptionally induced by the androgenic hormone 5alpha-dihydrotestosterone ( DHT ) ."
],
"offsets": [
[
0,
227
]
]
}
]
| [
{
"id": "split_0_train_3464_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
14,
20
]
],
"normalized": []
},
{
"id": "split_0_train_3465_entity",
"type": "progene_text",
"text": [
"protein kinase"
],
"offsets": [
[
61,
75
]
],
"normalized": []
},
{
"id": "split_0_train_3466_entity",
"type": "progene_text",
"text": [
"male germ cell - associated kinase"
],
"offsets": [
[
84,
118
]
],
"normalized": []
},
{
"id": "split_0_train_3467_entity",
"type": "progene_text",
"text": [
"hMAK"
],
"offsets": [
[
121,
125
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2317 | split_0_train_2317 | [
{
"id": "split_0_train_2317_passage",
"type": "progene_text",
"text": [
"The kinetics of induction is rapid and dose - dependent , and the induction is not blocked by cycloheximide treatment ."
],
"offsets": [
[
0,
119
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2318 | split_0_train_2318 | [
{
"id": "split_0_train_2318_passage",
"type": "progene_text",
"text": [
"Real time reverse transcription - PCR studies demonstrated a 9 - fold induction of hMAK by 10 nm DHT at 24 h post - stimulation ."
],
"offsets": [
[
0,
129
]
]
}
]
| [
{
"id": "split_0_train_3468_entity",
"type": "progene_text",
"text": [
"hMAK"
],
"offsets": [
[
83,
87
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2319 | split_0_train_2319 | [
{
"id": "split_0_train_2319_passage",
"type": "progene_text",
"text": [
"The expression levels of hMAK in prostate cancer cell lines are in general higher than those of normal prostate epithelial cells ."
],
"offsets": [
[
0,
130
]
]
}
]
| [
{
"id": "split_0_train_3469_entity",
"type": "progene_text",
"text": [
"hMAK"
],
"offsets": [
[
25,
29
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2320 | split_0_train_2320 | [
{
"id": "split_0_train_2320_passage",
"type": "progene_text",
"text": [
"A reverse transcription - PCR product encompassing the entire hMAK open reading frame was isolated ."
],
"offsets": [
[
0,
100
]
]
}
]
| [
{
"id": "split_0_train_3470_entity",
"type": "progene_text",
"text": [
"hMAK"
],
"offsets": [
[
62,
66
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2321 | split_0_train_2321 | [
{
"id": "split_0_train_2321_passage",
"type": "progene_text",
"text": [
"The results from sequencing analysis showed that the hMAK protein is 623 amino acids in length and contains a kinase catalytic domain at its N terminus , followed by a proline / glutamine - rich domain ."
],
"offsets": [
[
0,
203
]
]
}
]
| [
{
"id": "split_0_train_3471_entity",
"type": "progene_text",
"text": [
"hMAK"
],
"offsets": [
[
53,
57
]
],
"normalized": []
},
{
"id": "split_0_train_3472_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
110,
116
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2322 | split_0_train_2322 | [
{
"id": "split_0_train_2322_passage",
"type": "progene_text",
"text": [
"The catalytic domain of this kinase contains sequence motifs related to both the cyclin - dependent kinase and the mitogen - activated protein kinase families ."
],
"offsets": [
[
0,
160
]
]
}
]
| [
{
"id": "split_0_train_3473_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
29,
35
]
],
"normalized": []
},
{
"id": "split_0_train_3474_entity",
"type": "progene_text",
"text": [
"cyclin - dependent kinase and the mitogen - activated protein kinase families"
],
"offsets": [
[
81,
158
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2323 | split_0_train_2323 | [
{
"id": "split_0_train_2323_passage",
"type": "progene_text",
"text": [
"When expressed in COS1 cells , hMAK is kinase - active as demonstrated by autophosphorylation and phosphorylation of exogenous substrate and is localized in the nucleus ."
],
"offsets": [
[
0,
170
]
]
}
]
| [
{
"id": "split_0_train_3475_entity",
"type": "progene_text",
"text": [
"hMAK"
],
"offsets": [
[
31,
35
]
],
"normalized": []
},
{
"id": "split_0_train_3476_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
39,
45
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2324 | split_0_train_2324 | [
{
"id": "split_0_train_2324_passage",
"type": "progene_text",
"text": [
"A 3.7 - kilobase pair promoter of the hMAK locus was isolated from a human genomic DNA bacterial artificial chromosome clone and was shown to be activated by DHT ."
],
"offsets": [
[
0,
163
]
]
}
]
| [
{
"id": "split_0_train_3477_entity",
"type": "progene_text",
"text": [
"hMAK"
],
"offsets": [
[
38,
42
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2325 | split_0_train_2325 | [
{
"id": "split_0_train_2325_passage",
"type": "progene_text",
"text": [
"This activation can be blocked by an anti - androgen drug bicalutamide ( Casodex ) , implicating the involvement of androgen receptor in this process ."
],
"offsets": [
[
0,
151
]
]
}
]
| [
{
"id": "split_0_train_3478_entity",
"type": "progene_text",
"text": [
"androgen receptor"
],
"offsets": [
[
116,
133
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2326 | split_0_train_2326 | [
{
"id": "split_0_train_2326_passage",
"type": "progene_text",
"text": [
"Taken together , these data suggest that hMAK is a protein kinase targeted by androgen that may participate in androgen - mediated signaling in prostate cancer cells ."
],
"offsets": [
[
0,
167
]
]
}
]
| [
{
"id": "split_0_train_3479_entity",
"type": "progene_text",
"text": [
"hMAK"
],
"offsets": [
[
41,
45
]
],
"normalized": []
},
{
"id": "split_0_train_3480_entity",
"type": "progene_text",
"text": [
"protein kinase"
],
"offsets": [
[
51,
65
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2327 | split_0_train_2327 | [
{
"id": "split_0_train_2327_passage",
"type": "progene_text",
"text": [
"Microanatomical localization of PD-1 in human tonsils ."
],
"offsets": [
[
0,
55
]
]
}
]
| [
{
"id": "split_0_train_3481_entity",
"type": "progene_text",
"text": [
"PD-1"
],
"offsets": [
[
32,
36
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2328 | split_0_train_2328 | [
{
"id": "split_0_train_2328_passage",
"type": "progene_text",
"text": [
"PD-1 is an immunoinhibitory receptor , which belongs structurally to the CD28 family ."
],
"offsets": [
[
0,
86
]
]
}
]
| [
{
"id": "split_0_train_3482_entity",
"type": "progene_text",
"text": [
"PD-1"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_3483_entity",
"type": "progene_text",
"text": [
"CD28 family"
],
"offsets": [
[
73,
84
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2329 | split_0_train_2329 | [
{
"id": "split_0_train_2329_passage",
"type": "progene_text",
"text": [
"PD-1 - deficient mice show breakdown of peripheral tolerance and manifest multiple autoimmune symptoms ."
],
"offsets": [
[
0,
104
]
]
}
]
| [
{
"id": "split_0_train_3484_entity",
"type": "progene_text",
"text": [
"PD-1"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2330 | split_0_train_2330 | [
{
"id": "split_0_train_2330_passage",
"type": "progene_text",
"text": [
"We previously described expression of PD-1 on activated T and B lymphocytes and myeloid cells ."
],
"offsets": [
[
0,
95
]
]
}
]
| [
{
"id": "split_0_train_3485_entity",
"type": "progene_text",
"text": [
"PD-1"
],
"offsets": [
[
38,
42
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2331 | split_0_train_2331 | [
{
"id": "split_0_train_2331_passage",
"type": "progene_text",
"text": [
"However , little is known about the microanatomical distribution of PD-1 in lymphoid organs ."
],
"offsets": [
[
0,
93
]
]
}
]
| [
{
"id": "split_0_train_3486_entity",
"type": "progene_text",
"text": [
"PD-1"
],
"offsets": [
[
68,
72
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2332 | split_0_train_2332 | [
{
"id": "split_0_train_2332_passage",
"type": "progene_text",
"text": [
"In this study , we performed immunohistochemistry using monoclonal antibodies against human PD-1 ."
],
"offsets": [
[
0,
98
]
]
}
]
| [
{
"id": "split_0_train_3487_entity",
"type": "progene_text",
"text": [
"PD-1"
],
"offsets": [
[
92,
96
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2333 | split_0_train_2333 | [
{
"id": "split_0_train_2333_passage",
"type": "progene_text",
"text": [
"In human tonsils , PD-1 was expressed on most of T cells and a small subset of centrocytes in the light zone of germinal centers ( GCs ) , where clonal selection of centrocytes takes place ."
],
"offsets": [
[
0,
190
]
]
}
]
| [
{
"id": "split_0_train_3488_entity",
"type": "progene_text",
"text": [
"PD-1"
],
"offsets": [
[
19,
23
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2334 | split_0_train_2334 | [
{
"id": "split_0_train_2334_passage",
"type": "progene_text",
"text": [
"These results suggest that PD-1 may play an important role in GC reaction ."
],
"offsets": [
[
0,
75
]
]
}
]
| [
{
"id": "split_0_train_3489_entity",
"type": "progene_text",
"text": [
"PD-1"
],
"offsets": [
[
27,
31
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2335 | split_0_train_2335 | [
{
"id": "split_0_train_2335_passage",
"type": "progene_text",
"text": [
"Mass spectrometric analysis of GAP-43 / neuromodulin reveals the presence of a variety of fatty acylated species ."
],
"offsets": [
[
0,
114
]
]
}
]
| [
{
"id": "split_0_train_3490_entity",
"type": "progene_text",
"text": [
"GAP-43"
],
"offsets": [
[
31,
37
]
],
"normalized": []
},
{
"id": "split_0_train_3491_entity",
"type": "progene_text",
"text": [
"neuromodulin"
],
"offsets": [
[
40,
52
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2336 | split_0_train_2336 | [
{
"id": "split_0_train_2336_passage",
"type": "progene_text",
"text": [
"GAP-43 ( neuromodulin ) is a protein kinase C substrate that is abundant in developing and regenerating neurons ."
],
"offsets": [
[
0,
113
]
]
}
]
| [
{
"id": "split_0_train_3492_entity",
"type": "progene_text",
"text": [
"GAP-43"
],
"offsets": [
[
0,
6
]
],
"normalized": []
},
{
"id": "split_0_train_3493_entity",
"type": "progene_text",
"text": [
"neuromodulin"
],
"offsets": [
[
9,
21
]
],
"normalized": []
},
{
"id": "split_0_train_3494_entity",
"type": "progene_text",
"text": [
"protein kinase C"
],
"offsets": [
[
29,
45
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2337 | split_0_train_2337 | [
{
"id": "split_0_train_2337_passage",
"type": "progene_text",
"text": [
"Thioester - linked palmitoylation at two cysteines near the GAP-43 N terminus has been implicated in directing membrane binding ."
],
"offsets": [
[
0,
129
]
]
}
]
| [
{
"id": "split_0_train_3495_entity",
"type": "progene_text",
"text": [
"GAP-43"
],
"offsets": [
[
60,
66
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2338 | split_0_train_2338 | [
{
"id": "split_0_train_2338_passage",
"type": "progene_text",
"text": [
"Here , we use mass spectrometry to examine the stoichiometry of palmitoylation and the molecular identity of the fatty acid(s) attached to GAP-43 in vivo ."
],
"offsets": [
[
0,
155
]
]
}
]
| [
{
"id": "split_0_train_3496_entity",
"type": "progene_text",
"text": [
"GAP-43"
],
"offsets": [
[
139,
145
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2339 | split_0_train_2339 | [
{
"id": "split_0_train_2339_passage",
"type": "progene_text",
"text": [
"GAP-43 expressed in either PC12 or COS-1 cells was acetylated at the N - terminal methionine ."
],
"offsets": [
[
0,
94
]
]
}
]
| [
{
"id": "split_0_train_3497_entity",
"type": "progene_text",
"text": [
"GAP-43"
],
"offsets": [
[
0,
6
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2340 | split_0_train_2340 | [
{
"id": "split_0_train_2340_passage",
"type": "progene_text",
"text": [
"Approximately 35 % of the N - terminal GAP - 43 peptides were also modified by palmitate and/or stearate on Cys residues ."
],
"offsets": [
[
0,
122
]
]
}
]
| [
{
"id": "split_0_train_3498_entity",
"type": "progene_text",
"text": [
"GAP - 43"
],
"offsets": [
[
39,
47
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2341 | split_0_train_2341 | [
{
"id": "split_0_train_2341_passage",
"type": "progene_text",
"text": [
"Interestingly , a variety of acylated species was detected , in which one of the Cys residues was acylated by either palmitate or stearate , or both Cys residues were acylated by palmitates or stearates or a combination of palmitate and stearate ."
],
"offsets": [
[
0,
247
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2342 | split_0_train_2342 | [
{
"id": "split_0_train_2342_passage",
"type": "progene_text",
"text": [
"Depalmitoylation of membrane - bound GAP-43 did not release the protein from the membrane , implying that additional forces function to maintain membrane binding ."
],
"offsets": [
[
0,
163
]
]
}
]
| [
{
"id": "split_0_train_3499_entity",
"type": "progene_text",
"text": [
"GAP-43"
],
"offsets": [
[
37,
43
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2343 | split_0_train_2343 | [
{
"id": "split_0_train_2343_passage",
"type": "progene_text",
"text": [
"Indeed , mutation of four basic residues within the N - terminal domain of GAP-43 dramatically reduced membrane localization of GAP-43 without affecting palmitoylation ."
],
"offsets": [
[
0,
169
]
]
}
]
| [
{
"id": "split_0_train_3500_entity",
"type": "progene_text",
"text": [
"GAP-43"
],
"offsets": [
[
75,
81
]
],
"normalized": []
},
{
"id": "split_0_train_3501_entity",
"type": "progene_text",
"text": [
"GAP-43"
],
"offsets": [
[
128,
134
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2344 | split_0_train_2344 | [
{
"id": "split_0_train_2344_passage",
"type": "progene_text",
"text": [
"These data reveal the heterogeneous nature of S-acylation in vivo and illustrate the power of mass spectrometry for identification of key regulatory protein modifications ."
],
"offsets": [
[
0,
172
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2345 | split_0_train_2345 | [
{
"id": "split_0_train_2345_passage",
"type": "progene_text",
"text": [
"Inflammatory mediator mRNA expression by adenovirus E1A - transfected bronchial epithelial cells ."
],
"offsets": [
[
0,
98
]
]
}
]
| [
{
"id": "split_0_train_3502_entity",
"type": "progene_text",
"text": [
"E1A"
],
"offsets": [
[
52,
55
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2346 | split_0_train_2346 | [
{
"id": "split_0_train_2346_passage",
"type": "progene_text",
"text": [
"Lung tissue from patients with emphysema and airway obstruction carries excess adenoviral E1A DNA that is expressed as protein in airway surface epithelium and is associated with an increased inflammatory response ."
],
"offsets": [
[
0,
215
]
]
}
]
| [
{
"id": "split_0_train_3503_entity",
"type": "progene_text",
"text": [
"E1A"
],
"offsets": [
[
90,
93
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2347 | split_0_train_2347 | [
{
"id": "split_0_train_2347_passage",
"type": "progene_text",
"text": [
"To examine mechanisms by which latent adenoviral infection might amplify the inflammatory process , we transfected primary human bronchial epithelial ( HBE ) cells from three separate patients undergoing lung resection so that they stably expressed adenovirus E1A ."
],
"offsets": [
[
0,
265
]
]
}
]
| [
{
"id": "split_0_train_3504_entity",
"type": "progene_text",
"text": [
"E1A"
],
"offsets": [
[
260,
263
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2348 | split_0_train_2348 | [
{
"id": "split_0_train_2348_passage",
"type": "progene_text",
"text": [
"Lipopolysaccharide stimulation of the E1A - transfected HBE cells increased intercellular adhesion molecule-1 and interleukin-8 mRNA and protein expression compared with control cells from the same patient ."
],
"offsets": [
[
0,
207
]
]
}
]
| [
{
"id": "split_0_train_3505_entity",
"type": "progene_text",
"text": [
"E1A"
],
"offsets": [
[
38,
41
]
],
"normalized": []
},
{
"id": "split_0_train_3506_entity",
"type": "progene_text",
"text": [
"intercellular adhesion molecule-1"
],
"offsets": [
[
76,
109
]
],
"normalized": []
},
{
"id": "split_0_train_3507_entity",
"type": "progene_text",
"text": [
"interleukin-8"
],
"offsets": [
[
114,
127
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2349 | split_0_train_2349 | [
{
"id": "split_0_train_2349_passage",
"type": "progene_text",
"text": [
"It also induced greater intercellular adhesion molecule-1 promoter activity and greater nuclear factor - kappa B binding activity of nuclear extracts in E1A transfectants than controls ."
],
"offsets": [
[
0,
186
]
]
}
]
| [
{
"id": "split_0_train_3508_entity",
"type": "progene_text",
"text": [
"intercellular adhesion molecule-1"
],
"offsets": [
[
24,
57
]
],
"normalized": []
},
{
"id": "split_0_train_3509_entity",
"type": "progene_text",
"text": [
"nuclear factor - kappa B"
],
"offsets": [
[
88,
112
]
],
"normalized": []
},
{
"id": "split_0_train_3510_entity",
"type": "progene_text",
"text": [
"E1A"
],
"offsets": [
[
153,
156
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2350 | split_0_train_2350 | [
{
"id": "split_0_train_2350_passage",
"type": "progene_text",
"text": [
"E1A - positive transfectants constitutively expressed transforming growth factor - beta 1 mRNA and protein , whereas this expression was either very low or not detected in control cells ."
],
"offsets": [
[
0,
187
]
]
}
]
| [
{
"id": "split_0_train_3511_entity",
"type": "progene_text",
"text": [
"E1A"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_3512_entity",
"type": "progene_text",
"text": [
"transforming growth factor - beta 1"
],
"offsets": [
[
54,
89
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2351 | split_0_train_2351 | [
{
"id": "split_0_train_2351_passage",
"type": "progene_text",
"text": [
"We conclude that adenoviral E1A transfection transforms primary HBE cells and upregulates their production of mediators that are clinically relevant to the pathogenesis of chronic obstructive pulmonary disease ."
],
"offsets": [
[
0,
211
]
]
}
]
| [
{
"id": "split_0_train_3513_entity",
"type": "progene_text",
"text": [
"E1A"
],
"offsets": [
[
28,
31
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2352 | split_0_train_2352 | [
{
"id": "split_0_train_2352_passage",
"type": "progene_text",
"text": [
"Trauma - haemorrhage - induced alterations in thymic prolactin receptor expression : implications in immune dysfunction ."
],
"offsets": [
[
0,
121
]
]
}
]
| [
{
"id": "split_0_train_3514_entity",
"type": "progene_text",
"text": [
"prolactin receptor"
],
"offsets": [
[
53,
71
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2353 | split_0_train_2353 | [
{
"id": "split_0_train_2353_passage",
"type": "progene_text",
"text": [
"Male gender and age appear to be causative factors in development of immunodepression and septic complications following trauma - haemorrhage ."
],
"offsets": [
[
0,
143
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2354 | split_0_train_2354 | [
{
"id": "split_0_train_2354_passage",
"type": "progene_text",
"text": [
"Studies have demonstrated that administration of the sex hormone prolactin following trauma - haemorrhage in male mice prevents immunodepression ."
],
"offsets": [
[
0,
146
]
]
}
]
| [
{
"id": "split_0_train_3515_entity",
"type": "progene_text",
"text": [
"prolactin"
],
"offsets": [
[
65,
74
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2355 | split_0_train_2355 | [
{
"id": "split_0_train_2355_passage",
"type": "progene_text",
"text": [
"Since the thymus is the primary location of the T-cell - lymphopoiesis , we investigated the effect of trauma - haemorrhage to thymic prolactin - receptor ( PRLr ) - expression in male and proestrus female mice in three different age groups ( young , adult , aged ) by flow cytometry and PCR ."
],
"offsets": [
[
0,
293
]
]
}
]
| [
{
"id": "split_0_train_3516_entity",
"type": "progene_text",
"text": [
"prolactin - receptor"
],
"offsets": [
[
134,
154
]
],
"normalized": []
},
{
"id": "split_0_train_3517_entity",
"type": "progene_text",
"text": [
"PRLr"
],
"offsets": [
[
157,
161
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2356 | split_0_train_2356 | [
{
"id": "split_0_train_2356_passage",
"type": "progene_text",
"text": [
"C3H/HeN mice were subjected to laparotomy ( i.e. , soft - tissue trauma ) and hemorrhagic shock ( 35 +/-5mmHg for 90min , then resuscitated ) or sham operation ."
],
"offsets": [
[
0,
161
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2357 | split_0_train_2357 | [
{
"id": "split_0_train_2357_passage",
"type": "progene_text",
"text": [
"Twenty-four hours later thymocytes were isolated ."
],
"offsets": [
[
0,
50
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2358 | split_0_train_2358 | [
{
"id": "split_0_train_2358_passage",
"type": "progene_text",
"text": [
"Trauma - haemorrhage upregulated PRLr expression in young and mature mice of both genders , however , the increase was attenuated in females ."
],
"offsets": [
[
0,
142
]
]
}
]
| [
{
"id": "split_0_train_3518_entity",
"type": "progene_text",
"text": [
"PRLr"
],
"offsets": [
[
33,
37
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2359 | split_0_train_2359 | [
{
"id": "split_0_train_2359_passage",
"type": "progene_text",
"text": [
"In contrast , in aged mice PRLr expression was elevated in both genders , independent of trauma - haemorrhage and was not further increased under such conditions ."
],
"offsets": [
[
0,
163
]
]
}
]
| [
{
"id": "split_0_train_3519_entity",
"type": "progene_text",
"text": [
"PRLr"
],
"offsets": [
[
27,
31
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2360 | split_0_train_2360 | [
{
"id": "split_0_train_2360_passage",
"type": "progene_text",
"text": [
"These findings suggest that the gender dimorphism in the immune response to trauma - haemorrhage may in part be related to differences in thymic PRLr expression under such conditions ."
],
"offsets": [
[
0,
184
]
]
}
]
| [
{
"id": "split_0_train_3520_entity",
"type": "progene_text",
"text": [
"PRLr"
],
"offsets": [
[
145,
149
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2361 | split_0_train_2361 | [
{
"id": "split_0_train_2361_passage",
"type": "progene_text",
"text": [
"Spectrin - like repeats from dystrophin and alpha-actinin-2 are not functionally interchangeable ."
],
"offsets": [
[
0,
98
]
]
}
]
| [
{
"id": "split_0_train_3521_entity",
"type": "progene_text",
"text": [
"Spectrin"
],
"offsets": [
[
0,
8
]
],
"normalized": []
},
{
"id": "split_0_train_3522_entity",
"type": "progene_text",
"text": [
"dystrophin"
],
"offsets": [
[
29,
39
]
],
"normalized": []
},
{
"id": "split_0_train_3523_entity",
"type": "progene_text",
"text": [
"alpha-actinin-2"
],
"offsets": [
[
44,
59
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2362 | split_0_train_2362 | [
{
"id": "split_0_train_2362_passage",
"type": "progene_text",
"text": [
"Mutations in the dystrophin gene result in Duchenne muscular dystrophy ( DMD ) ."
],
"offsets": [
[
0,
80
]
]
}
]
| [
{
"id": "split_0_train_3524_entity",
"type": "progene_text",
"text": [
"dystrophin"
],
"offsets": [
[
17,
27
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2363 | split_0_train_2363 | [
{
"id": "split_0_train_2363_passage",
"type": "progene_text",
"text": [
"Dystrophin is a multidomain protein that functions to stabilize the sarcolemmal membrane during muscle contraction ."
],
"offsets": [
[
0,
116
]
]
}
]
| [
{
"id": "split_0_train_3525_entity",
"type": "progene_text",
"text": [
"Dystrophin"
],
"offsets": [
[
0,
10
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2364 | split_0_train_2364 | [
{
"id": "split_0_train_2364_passage",
"type": "progene_text",
"text": [
"The central rod domain has been proposed to act as a shock absorber , as a force transducer or as a spacer separating important N - and C - terminal domains that interact with actin and the dystrophin - glycoprotein complex ( DGC ) ."
],
"offsets": [
[
0,
233
]
]
}
]
| [
{
"id": "split_0_train_3526_entity",
"type": "progene_text",
"text": [
"actin"
],
"offsets": [
[
176,
181
]
],
"normalized": []
},
{
"id": "split_0_train_3527_entity",
"type": "progene_text",
"text": [
"dystrophin"
],
"offsets": [
[
190,
200
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2365 | split_0_train_2365 | [
{
"id": "split_0_train_2365_passage",
"type": "progene_text",
"text": [
"Structure / function studies demonstrated that deletion of large portions of the rod domain can result in the production of smaller , yet highly functional , dystrophin proteins ."
],
"offsets": [
[
0,
179
]
]
}
]
| [
{
"id": "split_0_train_3528_entity",
"type": "progene_text",
"text": [
"dystrophin"
],
"offsets": [
[
158,
168
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2366 | split_0_train_2366 | [
{
"id": "split_0_train_2366_passage",
"type": "progene_text",
"text": [
"In a dramatic example , a ' micro - dystrophin ' transgene containing only four dystrophin spectrin - like repeats resulted in complete correction of most of the symptoms associated with dystrophy in the mdx mouse model for DMD ."
],
"offsets": [
[
0,
229
]
]
}
]
| [
{
"id": "split_0_train_3529_entity",
"type": "progene_text",
"text": [
"dystrophin"
],
"offsets": [
[
36,
46
]
],
"normalized": []
},
{
"id": "split_0_train_3530_entity",
"type": "progene_text",
"text": [
"dystrophin"
],
"offsets": [
[
80,
90
]
],
"normalized": []
},
{
"id": "split_0_train_3531_entity",
"type": "progene_text",
"text": [
"spectrin"
],
"offsets": [
[
91,
99
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2367 | split_0_train_2367 | [
{
"id": "split_0_train_2367_passage",
"type": "progene_text",
"text": [
"Dystrophin shares considerable homology with the multidomain , actin - crosslinking protein alpha-actinin ."
],
"offsets": [
[
0,
107
]
]
}
]
| [
{
"id": "split_0_train_3532_entity",
"type": "progene_text",
"text": [
"Dystrophin"
],
"offsets": [
[
0,
10
]
],
"normalized": []
},
{
"id": "split_0_train_3533_entity",
"type": "progene_text",
"text": [
"actin"
],
"offsets": [
[
63,
68
]
],
"normalized": []
},
{
"id": "split_0_train_3534_entity",
"type": "progene_text",
"text": [
"alpha-actinin"
],
"offsets": [
[
92,
105
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2368 | split_0_train_2368 | [
{
"id": "split_0_train_2368_passage",
"type": "progene_text",
"text": [
"To explore the hypothesis that the dystrophin rod domain acts as a spacer region , a chimeric micro - dystrophin transgene containing the four - repeat rod domain of alpha-actinin-2 was expressed in mdx mice ."
],
"offsets": [
[
0,
209
]
]
}
]
| [
{
"id": "split_0_train_3535_entity",
"type": "progene_text",
"text": [
"dystrophin"
],
"offsets": [
[
35,
45
]
],
"normalized": []
},
{
"id": "split_0_train_3536_entity",
"type": "progene_text",
"text": [
"dystrophin"
],
"offsets": [
[
102,
112
]
],
"normalized": []
},
{
"id": "split_0_train_3537_entity",
"type": "progene_text",
"text": [
"alpha-actinin-2"
],
"offsets": [
[
166,
181
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2369 | split_0_train_2369 | [
{
"id": "split_0_train_2369_passage",
"type": "progene_text",
"text": [
"This chimeric transgene was incapable of correcting the morphological pathology of the mdx mouse , but still functioned to assemble the DGC at the membrane and provided some protection from contraction - induced injury ."
],
"offsets": [
[
0,
220
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2370 | split_0_train_2370 | [
{
"id": "split_0_train_2370_passage",
"type": "progene_text",
"text": [
"These data demonstrated that different spectrin - like repeats are not equivalent , and reinforced the suggestion that the dystrophin rod domain is not merely a spacer but likely contributes an important mechanical role to overall dystrophin function ."
],
"offsets": [
[
0,
252
]
]
}
]
| [
{
"id": "split_0_train_3538_entity",
"type": "progene_text",
"text": [
"spectrin"
],
"offsets": [
[
39,
47
]
],
"normalized": []
},
{
"id": "split_0_train_3539_entity",
"type": "progene_text",
"text": [
"dystrophin"
],
"offsets": [
[
123,
133
]
],
"normalized": []
},
{
"id": "split_0_train_3540_entity",
"type": "progene_text",
"text": [
"dystrophin"
],
"offsets": [
[
231,
241
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2371 | split_0_train_2371 | [
{
"id": "split_0_train_2371_passage",
"type": "progene_text",
"text": [
"Regulation of the CDK - related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells ."
],
"offsets": [
[
0,
119
]
]
}
]
| [
{
"id": "split_0_train_3541_entity",
"type": "progene_text",
"text": [
"CDK"
],
"offsets": [
[
18,
21
]
],
"normalized": []
},
{
"id": "split_0_train_3542_entity",
"type": "progene_text",
"text": [
"protein kinase"
],
"offsets": [
[
32,
46
]
],
"normalized": []
},
{
"id": "split_0_train_3543_entity",
"type": "progene_text",
"text": [
"PCTAIRE-1"
],
"offsets": [
[
47,
56
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2372 | split_0_train_2372 | [
{
"id": "split_0_train_2372_passage",
"type": "progene_text",
"text": [
"PCTAIRE-1 is a CDK - related protein kinase found in terminally differentiated cells in brain and testis , and in many immortalised and transformed cell lines ."
],
"offsets": [
[
0,
160
]
]
}
]
| [
{
"id": "split_0_train_3544_entity",
"type": "progene_text",
"text": [
"PCTAIRE-1"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "split_0_train_3545_entity",
"type": "progene_text",
"text": [
"CDK"
],
"offsets": [
[
15,
18
]
],
"normalized": []
},
{
"id": "split_0_train_3546_entity",
"type": "progene_text",
"text": [
"protein kinase"
],
"offsets": [
[
29,
43
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2373 | split_0_train_2373 | [
{
"id": "split_0_train_2373_passage",
"type": "progene_text",
"text": [
"Bacterially expressed PCTAIRE is completely inactive as a protein kinase , but is a very good substrate for protein kinase A ( PKA ) , which phosphorylates a total of four sites in the N-terminus of PCTAIRE-1 ."
],
"offsets": [
[
0,
210
]
]
}
]
| [
{
"id": "split_0_train_3547_entity",
"type": "progene_text",
"text": [
"PCTAIRE"
],
"offsets": [
[
22,
29
]
],
"normalized": []
},
{
"id": "split_0_train_3548_entity",
"type": "progene_text",
"text": [
"protein kinase"
],
"offsets": [
[
58,
72
]
],
"normalized": []
},
{
"id": "split_0_train_3549_entity",
"type": "progene_text",
"text": [
"protein kinase A"
],
"offsets": [
[
108,
124
]
],
"normalized": []
},
{
"id": "split_0_train_3550_entity",
"type": "progene_text",
"text": [
"PKA"
],
"offsets": [
[
127,
130
]
],
"normalized": []
},
{
"id": "split_0_train_3551_entity",
"type": "progene_text",
"text": [
"PCTAIRE-1"
],
"offsets": [
[
199,
208
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2374 | split_0_train_2374 | [
{
"id": "split_0_train_2374_passage",
"type": "progene_text",
"text": [
"Phosphorylation of one of these sites , Ser119 , generates a 14-3-3 binding site , which is functional in vitro as well as in vivo ."
],
"offsets": [
[
0,
132
]
]
}
]
| [
{
"id": "split_0_train_3552_entity",
"type": "progene_text",
"text": [
"14-3-3"
],
"offsets": [
[
61,
67
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2375 | split_0_train_2375 | [
{
"id": "split_0_train_2375_passage",
"type": "progene_text",
"text": [
"Mutation of another PKA site , Ser153 , to an alanine residue generated an activated kinase in transfected mammalian cells ."
],
"offsets": [
[
0,
124
]
]
}
]
| [
{
"id": "split_0_train_3553_entity",
"type": "progene_text",
"text": [
"PKA"
],
"offsets": [
[
20,
23
]
],
"normalized": []
},
{
"id": "split_0_train_3554_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
85,
91
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2376 | split_0_train_2376 | [
{
"id": "split_0_train_2376_passage",
"type": "progene_text",
"text": [
"This activity was comparable to that of CDK5 activated by a bacterially expressed , truncated version of p35 ( nck ) , p21 ."
],
"offsets": [
[
0,
124
]
]
}
]
| [
{
"id": "split_0_train_3555_entity",
"type": "progene_text",
"text": [
"CDK5"
],
"offsets": [
[
40,
44
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2377 | split_0_train_2377 | [
{
"id": "split_0_train_2377_passage",
"type": "progene_text",
"text": [
"Gel filtration analysis of a brain extract suggested that monomeric PCTAIRE-1 was the active species , implying that PCTAIRE-1 may not be a true CDK , in that it does not require a partner ( cyclin - like ) subunit for kinase activity ."
],
"offsets": [
[
0,
236
]
]
}
]
| [
{
"id": "split_0_train_3556_entity",
"type": "progene_text",
"text": [
"PCTAIRE-1"
],
"offsets": [
[
68,
77
]
],
"normalized": []
},
{
"id": "split_0_train_3557_entity",
"type": "progene_text",
"text": [
"PCTAIRE-1"
],
"offsets": [
[
117,
126
]
],
"normalized": []
},
{
"id": "split_0_train_3558_entity",
"type": "progene_text",
"text": [
"CDK"
],
"offsets": [
[
145,
148
]
],
"normalized": []
},
{
"id": "split_0_train_3559_entity",
"type": "progene_text",
"text": [
"cyclin"
],
"offsets": [
[
191,
197
]
],
"normalized": []
},
{
"id": "split_0_train_3560_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
219,
225
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2378 | split_0_train_2378 | [
{
"id": "split_0_train_2378_passage",
"type": "progene_text",
"text": [
"Finally , we found that various forms of PCTAIRE-1 transfected into neuroblastoma cell lines could either promote or inhibit neurite outgrowth , suggesting a potential role for the PCTAIRE-1 gene product in the control of neurite outgrowth ."
],
"offsets": [
[
0,
241
]
]
}
]
| [
{
"id": "split_0_train_3561_entity",
"type": "progene_text",
"text": [
"PCTAIRE-1"
],
"offsets": [
[
41,
50
]
],
"normalized": []
},
{
"id": "split_0_train_3562_entity",
"type": "progene_text",
"text": [
"PCTAIRE-1"
],
"offsets": [
[
181,
190
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2379 | split_0_train_2379 | [
{
"id": "split_0_train_2379_passage",
"type": "progene_text",
"text": [
"Generation and phenotypic analysis of CHIF knockout mice ."
],
"offsets": [
[
0,
58
]
]
}
]
| [
{
"id": "split_0_train_3563_entity",
"type": "progene_text",
"text": [
"CHIF"
],
"offsets": [
[
38,
42
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2380 | split_0_train_2380 | [
{
"id": "split_0_train_2380_passage",
"type": "progene_text",
"text": [
"Corticosteroid hormone - induced factor ( CHIF ) is a short epithelial - specific protein that is independently induced by aldosterone and a high - K(+) diet ."
],
"offsets": [
[
0,
159
]
]
}
]
| [
{
"id": "split_0_train_3564_entity",
"type": "progene_text",
"text": [
"Corticosteroid hormone - induced factor"
],
"offsets": [
[
0,
39
]
],
"normalized": []
},
{
"id": "split_0_train_3565_entity",
"type": "progene_text",
"text": [
"CHIF"
],
"offsets": [
[
42,
46
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2381 | split_0_train_2381 | [
{
"id": "split_0_train_2381_passage",
"type": "progene_text",
"text": [
"It is a member of the FXYD family of single - span transmembrane proteins that include phospholemman , Mat-8 , and the gamma - subunit of Na(+)-K(+) - ATPase ."
],
"offsets": [
[
0,
159
]
]
}
]
| [
{
"id": "split_0_train_3566_entity",
"type": "progene_text",
"text": [
"phospholemman"
],
"offsets": [
[
87,
100
]
],
"normalized": []
},
{
"id": "split_0_train_3567_entity",
"type": "progene_text",
"text": [
"Mat-8"
],
"offsets": [
[
103,
108
]
],
"normalized": []
},
{
"id": "split_0_train_3568_entity",
"type": "progene_text",
"text": [
"gamma - subunit of Na(+)-K(+) - ATPase"
],
"offsets": [
[
119,
157
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2382 | split_0_train_2382 | [
{
"id": "split_0_train_2382_passage",
"type": "progene_text",
"text": [
"A number of studies have suggested that these proteins are involved in the regulation of ion transport and , in particular , functionally interact with the Na(+)-K(+) - ATPase ."
],
"offsets": [
[
0,
177
]
]
}
]
| [
{
"id": "split_0_train_3569_entity",
"type": "progene_text",
"text": [
"Na(+)-K(+) - ATPase"
],
"offsets": [
[
156,
175
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2383 | split_0_train_2383 | [
{
"id": "split_0_train_2383_passage",
"type": "progene_text",
"text": [
"The present study describes the characterization , targeted disruption , and phenotypic analysis of the mouse CHIF gene ."
],
"offsets": [
[
0,
121
]
]
}
]
| [
{
"id": "split_0_train_3570_entity",
"type": "progene_text",
"text": [
"CHIF"
],
"offsets": [
[
110,
114
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2384 | split_0_train_2384 | [
{
"id": "split_0_train_2384_passage",
"type": "progene_text",
"text": [
"The CHIF knockout mice are viable and not distinguishable from wild - type littermates under normal conditions ."
],
"offsets": [
[
0,
112
]
]
}
]
| [
{
"id": "split_0_train_3571_entity",
"type": "progene_text",
"text": [
"CHIF"
],
"offsets": [
[
4,
8
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2385 | split_0_train_2385 | [
{
"id": "split_0_train_2385_passage",
"type": "progene_text",
"text": [
"Under K(+) loading , they have a twofold higher urine volume and an increased glomerular filtration rate ."
],
"offsets": [
[
0,
106
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2386 | split_0_train_2386 | [
{
"id": "split_0_train_2386_passage",
"type": "progene_text",
"text": [
"Similar but smaller effects are observed in mice fed a low-Na(+) diet ."
],
"offsets": [
[
0,
71
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2387 | split_0_train_2387 | [
{
"id": "split_0_train_2387_passage",
"type": "progene_text",
"text": [
"Treating K(+)-loaded mice for 10 days with furosemide resulted in lethality in the knockout mice ( 17 of 39 ) but not in the wild - type group ( 1 of 39 ) ."
],
"offsets": [
[
0,
156
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2388 | split_0_train_2388 | [
{
"id": "split_0_train_2388_passage",
"type": "progene_text",
"text": [
"The data are consistent with an effect of CHIF on the Na(+)-K(+)-ATPase that is specific to the outer and inner medullary duct , its major expression site ."
],
"offsets": [
[
0,
156
]
]
}
]
| [
{
"id": "split_0_train_3572_entity",
"type": "progene_text",
"text": [
"CHIF"
],
"offsets": [
[
42,
46
]
],
"normalized": []
},
{
"id": "split_0_train_3573_entity",
"type": "progene_text",
"text": [
"Na(+)-K(+)-ATPase"
],
"offsets": [
[
54,
71
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2389 | split_0_train_2389 | [
{
"id": "split_0_train_2389_passage",
"type": "progene_text",
"text": [
"Some human KIR haplotypes contain two KIR2DL5 genes : KIR2DL5A and KIR2DL5B ."
],
"offsets": [
[
0,
77
]
]
}
]
| [
{
"id": "split_0_train_3574_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
11,
14
]
],
"normalized": []
},
{
"id": "split_0_train_3575_entity",
"type": "progene_text",
"text": [
"KIR2DL5"
],
"offsets": [
[
38,
45
]
],
"normalized": []
},
{
"id": "split_0_train_3576_entity",
"type": "progene_text",
"text": [
"KIR2DL5A"
],
"offsets": [
[
54,
62
]
],
"normalized": []
},
{
"id": "split_0_train_3577_entity",
"type": "progene_text",
"text": [
"KIR2DL5B"
],
"offsets": [
[
67,
75
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2390 | split_0_train_2390 | [
{
"id": "split_0_train_2390_passage",
"type": "progene_text",
"text": [
"Killer - cell immunoglobulin - like receptors ( KIR ) comprise a family of structurally diverse proteins encoded by a compact cluster of genes located in human Chromosome 19q13.4 ."
],
"offsets": [
[
0,
180
]
]
}
]
| [
{
"id": "split_0_train_3578_entity",
"type": "progene_text",
"text": [
"Killer - cell immunoglobulin - like receptors"
],
"offsets": [
[
0,
45
]
],
"normalized": []
},
{
"id": "split_0_train_3579_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
48,
51
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2391 | split_0_train_2391 | [
{
"id": "split_0_train_2391_passage",
"type": "progene_text",
"text": [
"The most recently described member of the KIR family , KIR2DL5 , is represented in human populations by at least four gene variants , whose exons differ by two to eight nucleotides ."
],
"offsets": [
[
0,
182
]
]
}
]
| [
{
"id": "split_0_train_3580_entity",
"type": "progene_text",
"text": [
"KIR family"
],
"offsets": [
[
42,
52
]
],
"normalized": []
},
{
"id": "split_0_train_3581_entity",
"type": "progene_text",
"text": [
"KIR2DL5"
],
"offsets": [
[
55,
62
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2392 | split_0_train_2392 | [
{
"id": "split_0_train_2392_passage",
"type": "progene_text",
"text": [
"We show here that these structurally similar variants are encoded by alleles of two different loci , KIR2DL5A and KIR2DL5B , which map to different regions of the KIR - gene cluster ."
],
"offsets": [
[
0,
183
]
]
}
]
| [
{
"id": "split_0_train_3582_entity",
"type": "progene_text",
"text": [
"KIR2DL5A"
],
"offsets": [
[
101,
109
]
],
"normalized": []
},
{
"id": "split_0_train_3583_entity",
"type": "progene_text",
"text": [
"KIR2DL5B"
],
"offsets": [
[
114,
122
]
],
"normalized": []
},
{
"id": "split_0_train_3584_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
163,
166
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2393 | split_0_train_2393 | [
{
"id": "split_0_train_2393_passage",
"type": "progene_text",
"text": [
"Regarding KIR2DL5 , four groups of KIR haplotypes can be distinguished : those having both KIR2DL5A and KIR2DL5B , those having either KIR2DL5A or KIR2DL5B , and those lacking KIR2DL5 ."
],
"offsets": [
[
0,
185
]
]
}
]
| [
{
"id": "split_0_train_3585_entity",
"type": "progene_text",
"text": [
"KIR2DL5"
],
"offsets": [
[
10,
17
]
],
"normalized": []
},
{
"id": "split_0_train_3586_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
35,
38
]
],
"normalized": []
},
{
"id": "split_0_train_3587_entity",
"type": "progene_text",
"text": [
"KIR2DL5A"
],
"offsets": [
[
91,
99
]
],
"normalized": []
},
{
"id": "split_0_train_3588_entity",
"type": "progene_text",
"text": [
"KIR2DL5B"
],
"offsets": [
[
104,
112
]
],
"normalized": []
},
{
"id": "split_0_train_3589_entity",
"type": "progene_text",
"text": [
"KIR2DL5A"
],
"offsets": [
[
135,
143
]
],
"normalized": []
},
{
"id": "split_0_train_3590_entity",
"type": "progene_text",
"text": [
"KIR2DL5B"
],
"offsets": [
[
147,
155
]
],
"normalized": []
},
{
"id": "split_0_train_3591_entity",
"type": "progene_text",
"text": [
"KIR2DL5"
],
"offsets": [
[
176,
183
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2394 | split_0_train_2394 | [
{
"id": "split_0_train_2394_passage",
"type": "progene_text",
"text": [
"Positive association between KIR2DL5A and KIR2DL5B was detected but did not reach statistical significance ."
],
"offsets": [
[
0,
108
]
]
}
]
| [
{
"id": "split_0_train_3592_entity",
"type": "progene_text",
"text": [
"KIR2DL5A"
],
"offsets": [
[
29,
37
]
],
"normalized": []
},
{
"id": "split_0_train_3593_entity",
"type": "progene_text",
"text": [
"KIR2DL5B"
],
"offsets": [
[
42,
50
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2395 | split_0_train_2395 | [
{
"id": "split_0_train_2395_passage",
"type": "progene_text",
"text": [
"These results are consistent with a model in which KIR2DL5A and KIR2DL5B are products of a gene duplication , which through the action of subsequent recombination have became separated on some haplotypes ."
],
"offsets": [
[
0,
205
]
]
}
]
| [
{
"id": "split_0_train_3594_entity",
"type": "progene_text",
"text": [
"KIR2DL5A"
],
"offsets": [
[
51,
59
]
],
"normalized": []
},
{
"id": "split_0_train_3595_entity",
"type": "progene_text",
"text": [
"KIR2DL5B"
],
"offsets": [
[
64,
72
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2396 | split_0_train_2396 | [
{
"id": "split_0_train_2396_passage",
"type": "progene_text",
"text": [
"Interaction of oncogenic papillomavirus E6 proteins with fibulin-1 ."
],
"offsets": [
[
0,
68
]
]
}
]
| [
{
"id": "split_0_train_3596_entity",
"type": "progene_text",
"text": [
"E6"
],
"offsets": [
[
40,
42
]
],
"normalized": []
},
{
"id": "split_0_train_3597_entity",
"type": "progene_text",
"text": [
"fibulin-1"
],
"offsets": [
[
57,
66
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2397 | split_0_train_2397 | [
{
"id": "split_0_train_2397_passage",
"type": "progene_text",
"text": [
"Human papillomavirus ( HPV ) infection is the primary risk factor for the development of cervical cancer ."
],
"offsets": [
[
0,
106
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2398 | split_0_train_2398 | [
{
"id": "split_0_train_2398_passage",
"type": "progene_text",
"text": [
"The papillomavirus E6 gene is essential for virus - induced cellular transformation and the viral life cycle ."
],
"offsets": [
[
0,
110
]
]
}
]
| [
{
"id": "split_0_train_3598_entity",
"type": "progene_text",
"text": [
"E6"
],
"offsets": [
[
19,
21
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2399 | split_0_train_2399 | [
{
"id": "split_0_train_2399_passage",
"type": "progene_text",
"text": [
"Important insight into the mechanism of E6 function came from the discovery that cancer - related HPV E6 proteins promote the degradation of the tumor suppressor p53 ."
],
"offsets": [
[
0,
167
]
]
}
]
| [
{
"id": "split_0_train_3599_entity",
"type": "progene_text",
"text": [
"E6"
],
"offsets": [
[
40,
42
]
],
"normalized": []
},
{
"id": "split_0_train_3600_entity",
"type": "progene_text",
"text": [
"E6"
],
"offsets": [
[
102,
104
]
],
"normalized": []
},
{
"id": "split_0_train_3601_entity",
"type": "progene_text",
"text": [
"tumor suppressor p53"
],
"offsets": [
[
145,
165
]
],
"normalized": []
}
]
| []
| []
| []
|
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