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stringlengths 15
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| passages
list | entities
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list | coreferences
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|---|---|---|---|---|---|---|
split_0_train_2400 | split_0_train_2400 | [
{
"id": "split_0_train_2400_passage",
"type": "progene_text",
"text": [
"However , mounting evidence indicates that interaction with p53 does not mediate all E6 activities ."
],
"offsets": [
[
0,
100
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]
}
]
| [
{
"id": "split_0_train_3602_entity",
"type": "progene_text",
"text": [
"p53"
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"offsets": [
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60,
63
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"normalized": []
},
{
"id": "split_0_train_3603_entity",
"type": "progene_text",
"text": [
"E6"
],
"offsets": [
[
85,
87
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2401 | split_0_train_2401 | [
{
"id": "split_0_train_2401_passage",
"type": "progene_text",
"text": [
"To explore the p53 - independent functions of E6 , we performed a yeast two - hybrid screen and identified fibulin-1 as an E6 binding protein ."
],
"offsets": [
[
0,
143
]
]
}
]
| [
{
"id": "split_0_train_3604_entity",
"type": "progene_text",
"text": [
"p53"
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15,
18
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{
"id": "split_0_train_3605_entity",
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"text": [
"E6"
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46,
48
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{
"id": "split_0_train_3606_entity",
"type": "progene_text",
"text": [
"fibulin-1"
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107,
116
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"normalized": []
},
{
"id": "split_0_train_3607_entity",
"type": "progene_text",
"text": [
"E6"
],
"offsets": [
[
123,
125
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2402 | split_0_train_2402 | [
{
"id": "split_0_train_2402_passage",
"type": "progene_text",
"text": [
"Fibulin-1 is a calcium - binding plasma and extracellular matrix protein that has been implicated in cellular transformation and tumor invasion ."
],
"offsets": [
[
0,
145
]
]
}
]
| [
{
"id": "split_0_train_3608_entity",
"type": "progene_text",
"text": [
"Fibulin-1"
],
"offsets": [
[
0,
9
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2403 | split_0_train_2403 | [
{
"id": "split_0_train_2403_passage",
"type": "progene_text",
"text": [
"The interaction between E6 and fibulin-1 was demonstrated by both in vitro and in vivo assays ."
],
"offsets": [
[
0,
95
]
]
}
]
| [
{
"id": "split_0_train_3609_entity",
"type": "progene_text",
"text": [
"E6"
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"offsets": [
[
24,
26
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"normalized": []
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{
"id": "split_0_train_3610_entity",
"type": "progene_text",
"text": [
"fibulin-1"
],
"offsets": [
[
31,
40
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2404 | split_0_train_2404 | [
{
"id": "split_0_train_2404_passage",
"type": "progene_text",
"text": [
"Fibulin-1 is associated specifically with cancer - related HPV E6s and the transforming bovine papillomavirus type 1 E6 ."
],
"offsets": [
[
0,
121
]
]
}
]
| [
{
"id": "split_0_train_3611_entity",
"type": "progene_text",
"text": [
"Fibulin-1"
],
"offsets": [
[
0,
9
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],
"normalized": []
},
{
"id": "split_0_train_3612_entity",
"type": "progene_text",
"text": [
"E6s"
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"offsets": [
[
63,
66
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],
"normalized": []
},
{
"id": "split_0_train_3613_entity",
"type": "progene_text",
"text": [
"E6"
],
"offsets": [
[
117,
119
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2405 | split_0_train_2405 | [
{
"id": "split_0_train_2405_passage",
"type": "progene_text",
"text": [
"Significantly , overexpression of fibulin-1 specifically inhibited E6 - mediated transformation ."
],
"offsets": [
[
0,
97
]
]
}
]
| [
{
"id": "split_0_train_3614_entity",
"type": "progene_text",
"text": [
"fibulin-1"
],
"offsets": [
[
34,
43
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],
"normalized": []
},
{
"id": "split_0_train_3615_entity",
"type": "progene_text",
"text": [
"E6"
],
"offsets": [
[
67,
69
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2406 | split_0_train_2406 | [
{
"id": "split_0_train_2406_passage",
"type": "progene_text",
"text": [
"These results suggest that fibulin-1 plays an important role in the biological activities of E6 ."
],
"offsets": [
[
0,
97
]
]
}
]
| [
{
"id": "split_0_train_3616_entity",
"type": "progene_text",
"text": [
"fibulin-1"
],
"offsets": [
[
27,
36
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],
"normalized": []
},
{
"id": "split_0_train_3617_entity",
"type": "progene_text",
"text": [
"E6"
],
"offsets": [
[
93,
95
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2407 | split_0_train_2407 | [
{
"id": "split_0_train_2407_passage",
"type": "progene_text",
"text": [
"Blocking the translation elongation factor-1 delta with its antisense mRNA results in a significant reversal of its oncogenic potential ."
],
"offsets": [
[
0,
137
]
]
}
]
| [
{
"id": "split_0_train_3618_entity",
"type": "progene_text",
"text": [
"translation elongation factor-1 delta"
],
"offsets": [
[
13,
50
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2408 | split_0_train_2408 | [
{
"id": "split_0_train_2408_passage",
"type": "progene_text",
"text": [
"In spite of the strong evidence for the carcinogenic activity of cadmium and its related compounds , the underlying molecular mechanisms that lead to malignant transformation in cells exposed to cadmium remain unknown ."
],
"offsets": [
[
0,
219
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2409 | split_0_train_2409 | [
{
"id": "split_0_train_2409_passage",
"type": "progene_text",
"text": [
"Recently , Joseph et al. [ J. Biol. Chem. 227 : 6131 - 6136 , 2002 ] have identified , cloned , and characterized the mouse Translation Elongation Factor-1 delta sub-unit ( TEF-1 delta , GenBank Accession Number AF304351 ) as a novel cadmium - responsive proto - oncogene ."
],
"offsets": [
[
0,
273
]
]
}
]
| [
{
"id": "split_0_train_3619_entity",
"type": "progene_text",
"text": [
"Translation Elongation Factor-1 delta"
],
"offsets": [
[
124,
161
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],
"normalized": []
},
{
"id": "split_0_train_3620_entity",
"type": "progene_text",
"text": [
"TEF-1 delta"
],
"offsets": [
[
173,
184
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2410 | split_0_train_2410 | [
{
"id": "split_0_train_2410_passage",
"type": "progene_text",
"text": [
"Presently , additional studies regarding the oncogenic potential of TEF-1 delta have been carried out ."
],
"offsets": [
[
0,
103
]
]
}
]
| [
{
"id": "split_0_train_3621_entity",
"type": "progene_text",
"text": [
"TEF-1 delta"
],
"offsets": [
[
68,
79
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2411 | split_0_train_2411 | [
{
"id": "split_0_train_2411_passage",
"type": "progene_text",
"text": [
"Transfection of NIH3T3 cells with the pcDNA3.1 expression vector containing the TEF-1 delta cDNA in the sense ( 5' --> 3' ) orientation resulted in overexpression of the encoded 31 kDa protein ."
],
"offsets": [
[
0,
194
]
]
}
]
| [
{
"id": "split_0_train_3622_entity",
"type": "progene_text",
"text": [
"TEF-1 delta"
],
"offsets": [
[
80,
91
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2412 | split_0_train_2412 | [
{
"id": "split_0_train_2412_passage",
"type": "progene_text",
"text": [
"Transfection - mediated overexpression of TEF-1 delta protein resulted in transformation of the cells as evidenced from the appearance of transformed foci ."
],
"offsets": [
[
0,
156
]
]
}
]
| [
{
"id": "split_0_train_3623_entity",
"type": "progene_text",
"text": [
"TEF-1 delta"
],
"offsets": [
[
42,
53
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2413 | split_0_train_2413 | [
{
"id": "split_0_train_2413_passage",
"type": "progene_text",
"text": [
"Cotransfection of the cells with a mixture of plasmid DNA consisting of TEF-1 delta cDNA in the sense ( 5' --> 3' ) and in the antisense ( 3' -->5' ) orientation resulted in significant inhibition of translation of the TEF-1 delta protein ."
],
"offsets": [
[
0,
240
]
]
}
]
| [
{
"id": "split_0_train_3624_entity",
"type": "progene_text",
"text": [
"TEF-1 delta"
],
"offsets": [
[
72,
83
]
],
"normalized": []
},
{
"id": "split_0_train_3625_entity",
"type": "progene_text",
"text": [
"TEF-1 delta"
],
"offsets": [
[
219,
230
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2414 | split_0_train_2414 | [
{
"id": "split_0_train_2414_passage",
"type": "progene_text",
"text": [
"Antisense TEF-1 delta mRNA - mediated inhibition of translation of TEF-1 delta protein , furthermore , resulted in inhibition of TEF-1 delta - mediated transformation of NIH3T3 cells as evidenced from the decrease in the number of transformed foci ."
],
"offsets": [
[
0,
249
]
]
}
]
| [
{
"id": "split_0_train_3626_entity",
"type": "progene_text",
"text": [
"TEF-1 delta"
],
"offsets": [
[
10,
21
]
],
"normalized": []
},
{
"id": "split_0_train_3627_entity",
"type": "progene_text",
"text": [
"TEF-1 delta"
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"offsets": [
[
67,
78
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],
"normalized": []
},
{
"id": "split_0_train_3628_entity",
"type": "progene_text",
"text": [
"TEF-1 delta"
],
"offsets": [
[
129,
140
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2415 | split_0_train_2415 | [
{
"id": "split_0_train_2415_passage",
"type": "progene_text",
"text": [
"These results further confirm that overexpression of TEF-1 delta is oncogenic and the antisense TEF-1 delta mRNA expression reverses its oncogenic potential ."
],
"offsets": [
[
0,
158
]
]
}
]
| [
{
"id": "split_0_train_3629_entity",
"type": "progene_text",
"text": [
"TEF-1 delta"
],
"offsets": [
[
53,
64
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],
"normalized": []
},
{
"id": "split_0_train_3630_entity",
"type": "progene_text",
"text": [
"TEF-1 delta"
],
"offsets": [
[
96,
107
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2416 | split_0_train_2416 | [
{
"id": "split_0_train_2416_passage",
"type": "progene_text",
"text": [
"Cutting edge : susceptibility to psoriatic arthritis : influence of activating killer Ig - like receptor genes in the absence of specific HLA-C alleles ."
],
"offsets": [
[
0,
153
]
]
}
]
| [
{
"id": "split_0_train_3631_entity",
"type": "progene_text",
"text": [
"killer Ig - like receptor"
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"offsets": [
[
79,
104
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},
{
"id": "split_0_train_3632_entity",
"type": "progene_text",
"text": [
"HLA-C"
],
"offsets": [
[
138,
143
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2417 | split_0_train_2417 | [
{
"id": "split_0_train_2417_passage",
"type": "progene_text",
"text": [
"NK cell activity is partially controlled through interactions between killer Ig - like receptors ( KIR ) on NK cells and their respective HLA class I ligands ."
],
"offsets": [
[
0,
159
]
]
}
]
| [
{
"id": "split_0_train_3633_entity",
"type": "progene_text",
"text": [
"killer Ig - like receptors"
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"offsets": [
[
70,
96
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],
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},
{
"id": "split_0_train_3634_entity",
"type": "progene_text",
"text": [
"KIR"
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"offsets": [
[
99,
102
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"normalized": []
},
{
"id": "split_0_train_3635_entity",
"type": "progene_text",
"text": [
"HLA class I"
],
"offsets": [
[
138,
149
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2418 | split_0_train_2418 | [
{
"id": "split_0_train_2418_passage",
"type": "progene_text",
"text": [
"Independent segregation of HLA and KIR genes , along with KIR specificity for particular HLA allotypes , raises the possibility that any given individual may express KIR molecules for which no ligand is present ."
],
"offsets": [
[
0,
212
]
]
}
]
| [
{
"id": "split_0_train_3636_entity",
"type": "progene_text",
"text": [
"HLA"
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"offsets": [
[
27,
30
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],
"normalized": []
},
{
"id": "split_0_train_3637_entity",
"type": "progene_text",
"text": [
"KIR"
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"offsets": [
[
35,
38
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],
"normalized": []
},
{
"id": "split_0_train_3638_entity",
"type": "progene_text",
"text": [
"KIR"
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"offsets": [
[
58,
61
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],
"normalized": []
},
{
"id": "split_0_train_3639_entity",
"type": "progene_text",
"text": [
"HLA"
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[
89,
92
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],
"normalized": []
},
{
"id": "split_0_train_3640_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
166,
169
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2419 | split_0_train_2419 | [
{
"id": "split_0_train_2419_passage",
"type": "progene_text",
"text": [
"Inhibitory receptor genes KIR2DL2 / 3 and KIR2DL1 were present in nearly all subjects sampled in this study , whereas their respective activating homologs , KIR2DS2 and KIR2DS1 , are each present in about half of the subjects ."
],
"offsets": [
[
0,
227
]
]
}
]
| [
{
"id": "split_0_train_3641_entity",
"type": "progene_text",
"text": [
"KIR2DL2 / 3"
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"offsets": [
[
26,
37
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],
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},
{
"id": "split_0_train_3642_entity",
"type": "progene_text",
"text": [
"KIR2DL1"
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"offsets": [
[
42,
49
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],
"normalized": []
},
{
"id": "split_0_train_3643_entity",
"type": "progene_text",
"text": [
"KIR2DS2"
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"offsets": [
[
157,
164
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],
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},
{
"id": "split_0_train_3644_entity",
"type": "progene_text",
"text": [
"KIR2DS1"
],
"offsets": [
[
169,
176
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2420 | split_0_train_2420 | [
{
"id": "split_0_train_2420_passage",
"type": "progene_text",
"text": [
"In this work we report that subjects with activating KIR2DS1 and/or KIR2DS2 genes are susceptible to developing psoriatic arthritis , but only when HLA ligands for their homologous inhibitory receptors , KIR2DL1 and KIR2DL2 / 3 , are missing ."
],
"offsets": [
[
0,
243
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]
}
]
| [
{
"id": "split_0_train_3645_entity",
"type": "progene_text",
"text": [
"KIR2DS1"
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"offsets": [
[
53,
60
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{
"id": "split_0_train_3646_entity",
"type": "progene_text",
"text": [
"KIR2DS2"
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68,
75
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},
{
"id": "split_0_train_3647_entity",
"type": "progene_text",
"text": [
"HLA"
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[
148,
151
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],
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},
{
"id": "split_0_train_3648_entity",
"type": "progene_text",
"text": [
"KIR2DL1"
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204,
211
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{
"id": "split_0_train_3649_entity",
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"text": [
"KIR2DL2 / 3"
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"offsets": [
[
216,
227
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2421 | split_0_train_2421 | [
{
"id": "split_0_train_2421_passage",
"type": "progene_text",
"text": [
"Absence of ligands for inhibitory KIRs could potentially lower the threshold for NK ( and / or T ) cell activation mediated through activating receptors , thereby contributing to pathogenesis of psoriatic arthritis ."
],
"offsets": [
[
0,
216
]
]
}
]
| [
{
"id": "split_0_train_3650_entity",
"type": "progene_text",
"text": [
"KIRs"
],
"offsets": [
[
34,
38
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2422 | split_0_train_2422 | [
{
"id": "split_0_train_2422_passage",
"type": "progene_text",
"text": [
"Distinctive response of thyroid - infiltrating mononuclear cells to B cell activation through CD40 and interleukin-4 in Graves ' patients ."
],
"offsets": [
[
0,
139
]
]
}
]
| [
{
"id": "split_0_train_3651_entity",
"type": "progene_text",
"text": [
"CD40"
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"offsets": [
[
94,
98
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],
"normalized": []
},
{
"id": "split_0_train_3652_entity",
"type": "progene_text",
"text": [
"interleukin-4"
],
"offsets": [
[
103,
116
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2423 | split_0_train_2423 | [
{
"id": "split_0_train_2423_passage",
"type": "progene_text",
"text": [
"The possible role of abnormal T cell - dependent B-cell activation in Graves ' disease was investigated by comparing lymphocyte subset distribution and the production of soluble CD8 ( sCD8 ) , sCD23 , IL-10 and IL-12 by peripheral blood cells ( PBMC ) and thyroid - infiltrating lymphocytes ( TL ) in vitro ."
],
"offsets": [
[
0,
308
]
]
}
]
| [
{
"id": "split_0_train_3653_entity",
"type": "progene_text",
"text": [
"CD8"
],
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[
178,
181
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},
{
"id": "split_0_train_3654_entity",
"type": "progene_text",
"text": [
"sCD8"
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[
184,
188
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],
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},
{
"id": "split_0_train_3655_entity",
"type": "progene_text",
"text": [
"sCD23"
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[
193,
198
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],
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},
{
"id": "split_0_train_3656_entity",
"type": "progene_text",
"text": [
"IL-10"
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201,
206
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{
"id": "split_0_train_3657_entity",
"type": "progene_text",
"text": [
"IL-12"
],
"offsets": [
[
211,
216
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2424 | split_0_train_2424 | [
{
"id": "split_0_train_2424_passage",
"type": "progene_text",
"text": [
"In TL , the percentage of CD8 ( + ) cells was slightly higher and the sCD8 concentration was significantly higher than in PBMC ."
],
"offsets": [
[
0,
128
]
]
}
]
| [
{
"id": "split_0_train_3658_entity",
"type": "progene_text",
"text": [
"CD8"
],
"offsets": [
[
26,
29
]
],
"normalized": []
},
{
"id": "split_0_train_3659_entity",
"type": "progene_text",
"text": [
"sCD8"
],
"offsets": [
[
70,
74
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2425 | split_0_train_2425 | [
{
"id": "split_0_train_2425_passage",
"type": "progene_text",
"text": [
"The ratio CD23 ( + ) cells to CD20 ( + ) cells ( activated B / pan B cells ) was increased in TL compared to PBMC from Graves ' or normal controls , although the percentage of CD20 ( + ) cells was decreased ."
],
"offsets": [
[
0,
208
]
]
}
]
| [
{
"id": "split_0_train_3660_entity",
"type": "progene_text",
"text": [
"CD23"
],
"offsets": [
[
10,
14
]
],
"normalized": []
},
{
"id": "split_0_train_3661_entity",
"type": "progene_text",
"text": [
"CD20"
],
"offsets": [
[
30,
34
]
],
"normalized": []
},
{
"id": "split_0_train_3662_entity",
"type": "progene_text",
"text": [
"CD20"
],
"offsets": [
[
176,
180
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2426 | split_0_train_2426 | [
{
"id": "split_0_train_2426_passage",
"type": "progene_text",
"text": [
"Compared to PBMC in Graves ' disease , the relative ratio of IL-10 to IL-12 release ( IL-10 / IL-12 ) by unstimulated TL was increased , despite a lack of significant difference between PBMC and TL in mean values for either IL-10 or IL-12 secretion ."
],
"offsets": [
[
0,
250
]
]
}
]
| [
{
"id": "split_0_train_3663_entity",
"type": "progene_text",
"text": [
"IL-10"
],
"offsets": [
[
61,
66
]
],
"normalized": []
},
{
"id": "split_0_train_3664_entity",
"type": "progene_text",
"text": [
"IL-12"
],
"offsets": [
[
70,
75
]
],
"normalized": []
},
{
"id": "split_0_train_3665_entity",
"type": "progene_text",
"text": [
"IL-10"
],
"offsets": [
[
86,
91
]
],
"normalized": []
},
{
"id": "split_0_train_3666_entity",
"type": "progene_text",
"text": [
"IL-12"
],
"offsets": [
[
94,
99
]
],
"normalized": []
},
{
"id": "split_0_train_3667_entity",
"type": "progene_text",
"text": [
"IL-10"
],
"offsets": [
[
224,
229
]
],
"normalized": []
},
{
"id": "split_0_train_3668_entity",
"type": "progene_text",
"text": [
"IL-12"
],
"offsets": [
[
233,
238
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2427 | split_0_train_2427 | [
{
"id": "split_0_train_2427_passage",
"type": "progene_text",
"text": [
"Incubating PBMC with a combination of anti - CD40 monoclonal antibodies and interleukin-4 ( IL-4 ) resulted in B cell activation , reflected in an increase in the sCD23 level in both controls and Graves ' patients , but especially prominent in the latter ."
],
"offsets": [
[
0,
256
]
]
}
]
| [
{
"id": "split_0_train_3669_entity",
"type": "progene_text",
"text": [
"CD40"
],
"offsets": [
[
45,
49
]
],
"normalized": []
},
{
"id": "split_0_train_3670_entity",
"type": "progene_text",
"text": [
"interleukin-4"
],
"offsets": [
[
76,
89
]
],
"normalized": []
},
{
"id": "split_0_train_3671_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
92,
96
]
],
"normalized": []
},
{
"id": "split_0_train_3672_entity",
"type": "progene_text",
"text": [
"sCD23"
],
"offsets": [
[
163,
168
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2428 | split_0_train_2428 | [
{
"id": "split_0_train_2428_passage",
"type": "progene_text",
"text": [
"Stimulation with anti - CD40 antibody and IL-4 also decreased the percentage of CD8 ( + ) cells in PBMC but not TL from both Graves ' disease and normal controls , and the percentage of CD8 ( + ) cells in TL was higher than PBMC after the stimulation ."
],
"offsets": [
[
0,
252
]
]
}
]
| [
{
"id": "split_0_train_3673_entity",
"type": "progene_text",
"text": [
"CD40"
],
"offsets": [
[
24,
28
]
],
"normalized": []
},
{
"id": "split_0_train_3674_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
42,
46
]
],
"normalized": []
},
{
"id": "split_0_train_3675_entity",
"type": "progene_text",
"text": [
"CD8"
],
"offsets": [
[
80,
83
]
],
"normalized": []
},
{
"id": "split_0_train_3676_entity",
"type": "progene_text",
"text": [
"CD8"
],
"offsets": [
[
186,
189
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2429 | split_0_train_2429 | [
{
"id": "split_0_train_2429_passage",
"type": "progene_text",
"text": [
"The sCD23 concentration in TL was decreased compared to PBMC both in patients with Graves ' disease and normal controls ."
],
"offsets": [
[
0,
121
]
]
}
]
| [
{
"id": "split_0_train_3677_entity",
"type": "progene_text",
"text": [
"sCD23"
],
"offsets": [
[
4,
9
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2430 | split_0_train_2430 | [
{
"id": "split_0_train_2430_passage",
"type": "progene_text",
"text": [
"However , in contrast to the increased responses observed in Graves ' PBMC or normal controls after stimulation , sCD23 levels remained the same in stimulated TL from Graves ' patients ."
],
"offsets": [
[
0,
186
]
]
}
]
| [
{
"id": "split_0_train_3678_entity",
"type": "progene_text",
"text": [
"sCD23"
],
"offsets": [
[
114,
119
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2431 | split_0_train_2431 | [
{
"id": "split_0_train_2431_passage",
"type": "progene_text",
"text": [
"This combination of B cell stimulants increased production of IL-10 in PBMC but not in TL obtained from patients with Graves ' disease , and the increased IL-10 / IL-12 ratio declined to a value no different from that in PBMC group after stimulation ."
],
"offsets": [
[
0,
251
]
]
}
]
| [
{
"id": "split_0_train_3679_entity",
"type": "progene_text",
"text": [
"IL-10"
],
"offsets": [
[
62,
67
]
],
"normalized": []
},
{
"id": "split_0_train_3680_entity",
"type": "progene_text",
"text": [
"IL-10"
],
"offsets": [
[
155,
160
]
],
"normalized": []
},
{
"id": "split_0_train_3681_entity",
"type": "progene_text",
"text": [
"IL-12"
],
"offsets": [
[
163,
168
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2432 | split_0_train_2432 | [
{
"id": "split_0_train_2432_passage",
"type": "progene_text",
"text": [
"Thus , T cell - dependent B-cell activation via a CD40 pathway may cause a shift in the Th(1) / Th(2) balance to Th(2) dominance in Graves ' disease , while increased CD8 ( + ) cells in TL may suppress sCD23 production and IL-10 - producing Th(2) cells ."
],
"offsets": [
[
0,
254
]
]
}
]
| [
{
"id": "split_0_train_3682_entity",
"type": "progene_text",
"text": [
"CD40"
],
"offsets": [
[
50,
54
]
],
"normalized": []
},
{
"id": "split_0_train_3683_entity",
"type": "progene_text",
"text": [
"CD8"
],
"offsets": [
[
167,
170
]
],
"normalized": []
},
{
"id": "split_0_train_3684_entity",
"type": "progene_text",
"text": [
"sCD23"
],
"offsets": [
[
202,
207
]
],
"normalized": []
},
{
"id": "split_0_train_3685_entity",
"type": "progene_text",
"text": [
"IL-10"
],
"offsets": [
[
223,
228
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2433 | split_0_train_2433 | [
{
"id": "split_0_train_2433_passage",
"type": "progene_text",
"text": [
"Mutations in ANKH cause chondrocalcinosis ."
],
"offsets": [
[
0,
43
]
]
}
]
| [
{
"id": "split_0_train_3686_entity",
"type": "progene_text",
"text": [
"ANKH"
],
"offsets": [
[
13,
17
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2434 | split_0_train_2434 | [
{
"id": "split_0_train_2434_passage",
"type": "progene_text",
"text": [
"Chondrocalcinosis ( CC ) is a common cause of joint pain and arthritis that is caused by the deposition of calcium - containing crystals within articular cartilage ."
],
"offsets": [
[
0,
165
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2435 | split_0_train_2435 | [
{
"id": "split_0_train_2435_passage",
"type": "progene_text",
"text": [
"Although most cases are sporadic , rare familial forms have been linked to human chromosomes 8 ( CCAL1 ) or 5p ( CCAL2 ) ( Baldwin et al. 1995 ; Hughes et al. 1995 ; Andrew et al. 1999 ) ."
],
"offsets": [
[
0,
188
]
]
}
]
| [
{
"id": "split_0_train_3687_entity",
"type": "progene_text",
"text": [
"CCAL1"
],
"offsets": [
[
97,
102
]
],
"normalized": []
},
{
"id": "split_0_train_3688_entity",
"type": "progene_text",
"text": [
"CCAL2"
],
"offsets": [
[
113,
118
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2436 | split_0_train_2436 | [
{
"id": "split_0_train_2436_passage",
"type": "progene_text",
"text": [
"Here , we show that two previously described families with CCAL2 have mutations in the human homolog of the mouse progressive ankylosis gene ( ANKH ) ."
],
"offsets": [
[
0,
151
]
]
}
]
| [
{
"id": "split_0_train_3689_entity",
"type": "progene_text",
"text": [
"CCAL2"
],
"offsets": [
[
59,
64
]
],
"normalized": []
},
{
"id": "split_0_train_3690_entity",
"type": "progene_text",
"text": [
"progressive ankylosis gene"
],
"offsets": [
[
114,
140
]
],
"normalized": []
},
{
"id": "split_0_train_3691_entity",
"type": "progene_text",
"text": [
"ANKH"
],
"offsets": [
[
143,
147
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2437 | split_0_train_2437 | [
{
"id": "split_0_train_2437_passage",
"type": "progene_text",
"text": [
"One of the human mutations results in the substitution of a highly conserved amino acid residue within a predicted transmembrane segment ."
],
"offsets": [
[
0,
138
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2438 | split_0_train_2438 | [
{
"id": "split_0_train_2438_passage",
"type": "progene_text",
"text": [
"The other creates a new ATG start site that adds four additional residues to the ANKH protein ."
],
"offsets": [
[
0,
95
]
]
}
]
| [
{
"id": "split_0_train_3692_entity",
"type": "progene_text",
"text": [
"ANKH"
],
"offsets": [
[
81,
85
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2439 | split_0_train_2439 | [
{
"id": "split_0_train_2439_passage",
"type": "progene_text",
"text": [
"Both mutations segregate completely with disease status and are not found in control subjects ."
],
"offsets": [
[
0,
95
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2440 | split_0_train_2440 | [
{
"id": "split_0_train_2440_passage",
"type": "progene_text",
"text": [
"In addition , 1 of 95 U.K. patients with sporadic CC showed a deletion of a single codon in the ANKH gene ."
],
"offsets": [
[
0,
107
]
]
}
]
| [
{
"id": "split_0_train_3693_entity",
"type": "progene_text",
"text": [
"ANKH"
],
"offsets": [
[
96,
100
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2441 | split_0_train_2441 | [
{
"id": "split_0_train_2441_passage",
"type": "progene_text",
"text": [
"The same change was found in a sister who had bilateral knee replacement for osteoarthritis ."
],
"offsets": [
[
0,
93
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2442 | split_0_train_2442 | [
{
"id": "split_0_train_2442_passage",
"type": "progene_text",
"text": [
"Each of the three human mutations was reconstructed in a full - length ANK expression construct previously shown to regulate pyrophosphate levels in cultured cells in vitro ."
],
"offsets": [
[
0,
174
]
]
}
]
| [
{
"id": "split_0_train_3694_entity",
"type": "progene_text",
"text": [
"ANK"
],
"offsets": [
[
71,
74
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2443 | split_0_train_2443 | [
{
"id": "split_0_train_2443_passage",
"type": "progene_text",
"text": [
"All three of the human mutations showed significantly more activity than a previously described nonsense mutation that causes severe hydroxyapatite mineral deposition and widespread joint ankylosis in mice ."
],
"offsets": [
[
0,
207
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2444 | split_0_train_2444 | [
{
"id": "split_0_train_2444_passage",
"type": "progene_text",
"text": [
"These results suggest that small sequence changes in ANKH are one cause of CC and joint disease in humans ."
],
"offsets": [
[
0,
107
]
]
}
]
| [
{
"id": "split_0_train_3695_entity",
"type": "progene_text",
"text": [
"ANKH"
],
"offsets": [
[
53,
57
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2445 | split_0_train_2445 | [
{
"id": "split_0_train_2445_passage",
"type": "progene_text",
"text": [
"Increased ANK activity may explain the different types of crystals commonly deposited in human CCAL2 families and mutant mice and may provide a useful pharmacological target for treating some forms of human CC ."
],
"offsets": [
[
0,
211
]
]
}
]
| [
{
"id": "split_0_train_3696_entity",
"type": "progene_text",
"text": [
"ANK"
],
"offsets": [
[
10,
13
]
],
"normalized": []
},
{
"id": "split_0_train_3697_entity",
"type": "progene_text",
"text": [
"CCAL2"
],
"offsets": [
[
95,
100
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2446 | split_0_train_2446 | [
{
"id": "split_0_train_2446_passage",
"type": "progene_text",
"text": [
"Vpr - and Nef - dependent induction of RANTES / CCL5 in microglial cells ."
],
"offsets": [
[
0,
74
]
]
}
]
| [
{
"id": "split_0_train_3698_entity",
"type": "progene_text",
"text": [
"Vpr"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_3699_entity",
"type": "progene_text",
"text": [
"Nef"
],
"offsets": [
[
10,
13
]
],
"normalized": []
},
{
"id": "split_0_train_3700_entity",
"type": "progene_text",
"text": [
"RANTES"
],
"offsets": [
[
39,
45
]
],
"normalized": []
},
{
"id": "split_0_train_3701_entity",
"type": "progene_text",
"text": [
"CCL5"
],
"offsets": [
[
48,
52
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2447 | split_0_train_2447 | [
{
"id": "split_0_train_2447_passage",
"type": "progene_text",
"text": [
"Microglia are pivotal in the pathogenesis of AIDS dementia , as they serve as the major target of HIV infection in the CNS ."
],
"offsets": [
[
0,
124
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2448 | split_0_train_2448 | [
{
"id": "split_0_train_2448_passage",
"type": "progene_text",
"text": [
"In addition , activation of microglia correlates best with clinical dementia ."
],
"offsets": [
[
0,
78
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2449 | split_0_train_2449 | [
{
"id": "split_0_train_2449_passage",
"type": "progene_text",
"text": [
"Although the beta-chemokine RANTES / CCL5 is important in modulating HIV infection as well as cellular activation , no information is available regarding how its expression is regulated in microglia by HIV-1 ."
],
"offsets": [
[
0,
209
]
]
}
]
| [
{
"id": "split_0_train_3702_entity",
"type": "progene_text",
"text": [
"beta-chemokine"
],
"offsets": [
[
13,
27
]
],
"normalized": []
},
{
"id": "split_0_train_3703_entity",
"type": "progene_text",
"text": [
"RANTES"
],
"offsets": [
[
28,
34
]
],
"normalized": []
},
{
"id": "split_0_train_3704_entity",
"type": "progene_text",
"text": [
"CCL5"
],
"offsets": [
[
37,
41
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2450 | split_0_train_2450 | [
{
"id": "split_0_train_2450_passage",
"type": "progene_text",
"text": [
"Here we report that RANTES / CCL5 expression is induced in microglia by HIV-1 , but that this requires infection by HIV-1 ."
],
"offsets": [
[
0,
123
]
]
}
]
| [
{
"id": "split_0_train_3705_entity",
"type": "progene_text",
"text": [
"RANTES"
],
"offsets": [
[
20,
26
]
],
"normalized": []
},
{
"id": "split_0_train_3706_entity",
"type": "progene_text",
"text": [
"CCL5"
],
"offsets": [
[
29,
33
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2451 | split_0_train_2451 | [
{
"id": "split_0_train_2451_passage",
"type": "progene_text",
"text": [
"This conclusion was supported by (1) the delayed kinetics coinciding with viral replication ; (2) the lack of effect of X4 viruses ; (3) inhibition by the reverse transcriptase inhibitor AZT , and (4) the lack of effect of cytokine antagonists or antibodies ."
],
"offsets": [
[
0,
259
]
]
}
]
| [
{
"id": "split_0_train_3707_entity",
"type": "progene_text",
"text": [
"reverse transcriptase"
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155,
176
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},
{
"id": "split_0_train_3708_entity",
"type": "progene_text",
"text": [
"cytokine"
],
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[
223,
231
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2452 | split_0_train_2452 | [
{
"id": "split_0_train_2452_passage",
"type": "progene_text",
"text": [
"Interestingly , RANTES / CCL5 production was dependent on the viral accessory protein Vpr , in addition to Nef , demonstrating a novel role for Vpr in chemokine induction in primary macrophage - type cells ."
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[
0,
207
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}
]
| [
{
"id": "split_0_train_3709_entity",
"type": "progene_text",
"text": [
"RANTES"
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16,
22
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},
{
"id": "split_0_train_3710_entity",
"type": "progene_text",
"text": [
"CCL5"
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25,
29
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},
{
"id": "split_0_train_3711_entity",
"type": "progene_text",
"text": [
"Vpr"
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[
86,
89
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},
{
"id": "split_0_train_3712_entity",
"type": "progene_text",
"text": [
"Nef"
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107,
110
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},
{
"id": "split_0_train_3713_entity",
"type": "progene_text",
"text": [
"Vpr"
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144,
147
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},
{
"id": "split_0_train_3714_entity",
"type": "progene_text",
"text": [
"chemokine"
],
"offsets": [
[
151,
160
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2453 | split_0_train_2453 | [
{
"id": "split_0_train_2453_passage",
"type": "progene_text",
"text": [
"Furthermore , the specific p38 MAP kinase inhibitor SB203580 augmented chemokine expression in microglia , indicating a negative role played by p38 ."
],
"offsets": [
[
0,
149
]
]
}
]
| [
{
"id": "split_0_train_3715_entity",
"type": "progene_text",
"text": [
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[
27,
41
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{
"id": "split_0_train_3716_entity",
"type": "progene_text",
"text": [
"chemokine"
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[
71,
80
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},
{
"id": "split_0_train_3717_entity",
"type": "progene_text",
"text": [
"p38"
],
"offsets": [
[
144,
147
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2454 | split_0_train_2454 | [
{
"id": "split_0_train_2454_passage",
"type": "progene_text",
"text": [
"These data suggest unique features of RANTES / CCL5 regulation by HIV-1 in human microglial cells ."
],
"offsets": [
[
0,
99
]
]
}
]
| [
{
"id": "split_0_train_3718_entity",
"type": "progene_text",
"text": [
"RANTES"
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[
38,
44
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],
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},
{
"id": "split_0_train_3719_entity",
"type": "progene_text",
"text": [
"CCL5"
],
"offsets": [
[
47,
51
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2455 | split_0_train_2455 | [
{
"id": "split_0_train_2455_passage",
"type": "progene_text",
"text": [
"The human perforin gene is a direct target of STAT4 activated by IL-12 in NK cells ."
],
"offsets": [
[
0,
84
]
]
}
]
| [
{
"id": "split_0_train_3720_entity",
"type": "progene_text",
"text": [
"perforin"
],
"offsets": [
[
10,
18
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"normalized": []
},
{
"id": "split_0_train_3721_entity",
"type": "progene_text",
"text": [
"STAT4"
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"offsets": [
[
46,
51
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],
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},
{
"id": "split_0_train_3722_entity",
"type": "progene_text",
"text": [
"IL-12"
],
"offsets": [
[
65,
70
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2456 | split_0_train_2456 | [
{
"id": "split_0_train_2456_passage",
"type": "progene_text",
"text": [
"IL-12 activates STAT4 by inducing tyrosine phosphorylation , homo - dimerization , and nuclear translocation in NK cells and thereby stimulates proliferation and activation of these cells ."
],
"offsets": [
[
0,
189
]
]
}
]
| [
{
"id": "split_0_train_3723_entity",
"type": "progene_text",
"text": [
"IL-12"
],
"offsets": [
[
0,
5
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],
"normalized": []
},
{
"id": "split_0_train_3724_entity",
"type": "progene_text",
"text": [
"STAT4"
],
"offsets": [
[
16,
21
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2457 | split_0_train_2457 | [
{
"id": "split_0_train_2457_passage",
"type": "progene_text",
"text": [
"The pore - forming protein perforin is a key effector protein for NK cell - and cytotoxic T lymphocyte - mediated cytolysis ."
],
"offsets": [
[
0,
125
]
]
}
]
| [
{
"id": "split_0_train_3725_entity",
"type": "progene_text",
"text": [
"perforin"
],
"offsets": [
[
27,
35
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2458 | split_0_train_2458 | [
{
"id": "split_0_train_2458_passage",
"type": "progene_text",
"text": [
"Here we demonstrate that IL-12 induces the expression of the perforin gene in human NK cell line , NKL ."
],
"offsets": [
[
0,
104
]
]
}
]
| [
{
"id": "split_0_train_3726_entity",
"type": "progene_text",
"text": [
"IL-12"
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"offsets": [
[
25,
30
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"normalized": []
},
{
"id": "split_0_train_3727_entity",
"type": "progene_text",
"text": [
"perforin"
],
"offsets": [
[
61,
69
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2459 | split_0_train_2459 | [
{
"id": "split_0_train_2459_passage",
"type": "progene_text",
"text": [
"Electrophoretic mobility shift assays using a probe containing two putative STAT - binding sequences located at - 1085 and - 1059 in the human perforin gene showed that STAT4 or STAT5 activated by IL-12 or IL-2 , respectively , in NKL cells binds this region ."
],
"offsets": [
[
0,
260
]
]
}
]
| [
{
"id": "split_0_train_3728_entity",
"type": "progene_text",
"text": [
"STAT"
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[
76,
80
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},
{
"id": "split_0_train_3729_entity",
"type": "progene_text",
"text": [
"perforin"
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[
143,
151
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],
"normalized": []
},
{
"id": "split_0_train_3730_entity",
"type": "progene_text",
"text": [
"STAT4"
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[
169,
174
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},
{
"id": "split_0_train_3731_entity",
"type": "progene_text",
"text": [
"STAT5"
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[
178,
183
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},
{
"id": "split_0_train_3732_entity",
"type": "progene_text",
"text": [
"IL-12"
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[
197,
202
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},
{
"id": "split_0_train_3733_entity",
"type": "progene_text",
"text": [
"IL-2"
],
"offsets": [
[
206,
210
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2460 | split_0_train_2460 | [
{
"id": "split_0_train_2460_passage",
"type": "progene_text",
"text": [
"Further analyses using various probes with or without mutated STAT - binding sequences showed that , although either of the two tandem STAT - binding sequences binds STAT4 weakly , the presence of both is required for significant binding of activated STAT4 and for formation of the STAT4 - DNA - binding complex with lower electrophoretic mobility ."
],
"offsets": [
[
0,
349
]
]
}
]
| [
{
"id": "split_0_train_3734_entity",
"type": "progene_text",
"text": [
"STAT"
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"offsets": [
[
62,
66
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"normalized": []
},
{
"id": "split_0_train_3735_entity",
"type": "progene_text",
"text": [
"STAT"
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[
135,
139
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],
"normalized": []
},
{
"id": "split_0_train_3736_entity",
"type": "progene_text",
"text": [
"STAT4"
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"offsets": [
[
166,
171
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],
"normalized": []
},
{
"id": "split_0_train_3737_entity",
"type": "progene_text",
"text": [
"STAT4"
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"offsets": [
[
251,
256
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],
"normalized": []
},
{
"id": "split_0_train_3738_entity",
"type": "progene_text",
"text": [
"STAT4"
],
"offsets": [
[
282,
287
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2461 | split_0_train_2461 | [
{
"id": "split_0_train_2461_passage",
"type": "progene_text",
"text": [
"Furthermore , mutation of either of the tandem STAT - binding sequences abolished the IL-12 - induced activation of the perforin gene promoter in reporter gene assays ."
],
"offsets": [
[
0,
168
]
]
}
]
| [
{
"id": "split_0_train_3739_entity",
"type": "progene_text",
"text": [
"STAT"
],
"offsets": [
[
47,
51
]
],
"normalized": []
},
{
"id": "split_0_train_3740_entity",
"type": "progene_text",
"text": [
"IL-12"
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"offsets": [
[
86,
91
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],
"normalized": []
},
{
"id": "split_0_train_3741_entity",
"type": "progene_text",
"text": [
"perforin"
],
"offsets": [
[
120,
128
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2462 | split_0_train_2462 | [
{
"id": "split_0_train_2462_passage",
"type": "progene_text",
"text": [
"These results indicate that the IL-12 - induced expression of the perforin gene in NK cells is directly regulated by STAT4 , which binds , most likely as a homo - tetramer , to the tandem STAT - binding sequences in the perforin gene promoter ."
],
"offsets": [
[
0,
244
]
]
}
]
| [
{
"id": "split_0_train_3742_entity",
"type": "progene_text",
"text": [
"IL-12"
],
"offsets": [
[
32,
37
]
],
"normalized": []
},
{
"id": "split_0_train_3743_entity",
"type": "progene_text",
"text": [
"perforin"
],
"offsets": [
[
66,
74
]
],
"normalized": []
},
{
"id": "split_0_train_3744_entity",
"type": "progene_text",
"text": [
"STAT4"
],
"offsets": [
[
117,
122
]
],
"normalized": []
},
{
"id": "split_0_train_3745_entity",
"type": "progene_text",
"text": [
"STAT"
],
"offsets": [
[
188,
192
]
],
"normalized": []
},
{
"id": "split_0_train_3746_entity",
"type": "progene_text",
"text": [
"perforin"
],
"offsets": [
[
220,
228
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2463 | split_0_train_2463 | [
{
"id": "split_0_train_2463_passage",
"type": "progene_text",
"text": [
"Regulatory effect of IFN-kappa , a novel type I IFN , on cytokine production by cells of the innate immune system ."
],
"offsets": [
[
0,
115
]
]
}
]
| [
{
"id": "split_0_train_3747_entity",
"type": "progene_text",
"text": [
"IFN-kappa"
],
"offsets": [
[
21,
30
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],
"normalized": []
},
{
"id": "split_0_train_3748_entity",
"type": "progene_text",
"text": [
"type I IFN"
],
"offsets": [
[
41,
51
]
],
"normalized": []
},
{
"id": "split_0_train_3749_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
57,
65
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2464 | split_0_train_2464 | [
{
"id": "split_0_train_2464_passage",
"type": "progene_text",
"text": [
"IFN-kappa is a recently identified type I IFN that exhibits both structural and functional homology with the other type I IFN subclasses ."
],
"offsets": [
[
0,
138
]
]
}
]
| [
{
"id": "split_0_train_3750_entity",
"type": "progene_text",
"text": [
"IFN-kappa"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "split_0_train_3751_entity",
"type": "progene_text",
"text": [
"type I IFN"
],
"offsets": [
[
35,
45
]
],
"normalized": []
},
{
"id": "split_0_train_3752_entity",
"type": "progene_text",
"text": [
"type I IFN"
],
"offsets": [
[
115,
125
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2465 | split_0_train_2465 | [
{
"id": "split_0_train_2465_passage",
"type": "progene_text",
"text": [
"In this study , we have investigated the effect of IFN-kappa on cells of the innate immune system by comparing cytokine release following treatment of human cells with either IFN-kappa or two recombinant IFN subtypes , IFN-beta and IFN-alpha2a ."
],
"offsets": [
[
0,
245
]
]
}
]
| [
{
"id": "split_0_train_3753_entity",
"type": "progene_text",
"text": [
"IFN-kappa"
],
"offsets": [
[
51,
60
]
],
"normalized": []
},
{
"id": "split_0_train_3754_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
111,
119
]
],
"normalized": []
},
{
"id": "split_0_train_3755_entity",
"type": "progene_text",
"text": [
"IFN-kappa"
],
"offsets": [
[
175,
184
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],
"normalized": []
},
{
"id": "split_0_train_3756_entity",
"type": "progene_text",
"text": [
"IFN"
],
"offsets": [
[
204,
207
]
],
"normalized": []
},
{
"id": "split_0_train_3757_entity",
"type": "progene_text",
"text": [
"IFN-beta"
],
"offsets": [
[
219,
227
]
],
"normalized": []
},
{
"id": "split_0_train_3758_entity",
"type": "progene_text",
"text": [
"IFN-alpha2a"
],
"offsets": [
[
232,
243
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2466 | split_0_train_2466 | [
{
"id": "split_0_train_2466_passage",
"type": "progene_text",
"text": [
"Although IFN-alpha2a failed to stimulate monocyte cytokine secretion , IFN-kappa , like IFN-beta , induced the release of several cytokines from both monocytes and dendritic cells , without the requirement of a costimulatory signal ."
],
"offsets": [
[
0,
233
]
]
}
]
| [
{
"id": "split_0_train_3759_entity",
"type": "progene_text",
"text": [
"IFN-alpha2a"
],
"offsets": [
[
9,
20
]
],
"normalized": []
},
{
"id": "split_0_train_3760_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
50,
58
]
],
"normalized": []
},
{
"id": "split_0_train_3761_entity",
"type": "progene_text",
"text": [
"IFN-kappa"
],
"offsets": [
[
71,
80
]
],
"normalized": []
},
{
"id": "split_0_train_3762_entity",
"type": "progene_text",
"text": [
"IFN-beta"
],
"offsets": [
[
88,
96
]
],
"normalized": []
},
{
"id": "split_0_train_3763_entity",
"type": "progene_text",
"text": [
"cytokines"
],
"offsets": [
[
130,
139
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2467 | split_0_train_2467 | [
{
"id": "split_0_train_2467_passage",
"type": "progene_text",
"text": [
"IFN-kappa was particularly effective in inhibiting inducible IL-12 release from monocytes ."
],
"offsets": [
[
0,
91
]
]
}
]
| [
{
"id": "split_0_train_3764_entity",
"type": "progene_text",
"text": [
"IFN-kappa"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "split_0_train_3765_entity",
"type": "progene_text",
"text": [
"IL-12"
],
"offsets": [
[
61,
66
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2468 | split_0_train_2468 | [
{
"id": "split_0_train_2468_passage",
"type": "progene_text",
"text": [
"Unlike IFN-beta , IFN-kappa did not induce release of IFN-gamma by PBL ."
],
"offsets": [
[
0,
72
]
]
}
]
| [
{
"id": "split_0_train_3766_entity",
"type": "progene_text",
"text": [
"IFN-beta"
],
"offsets": [
[
7,
15
]
],
"normalized": []
},
{
"id": "split_0_train_3767_entity",
"type": "progene_text",
"text": [
"IFN-kappa"
],
"offsets": [
[
18,
27
]
],
"normalized": []
},
{
"id": "split_0_train_3768_entity",
"type": "progene_text",
"text": [
"IFN-gamma"
],
"offsets": [
[
54,
63
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2469 | split_0_train_2469 | [
{
"id": "split_0_train_2469_passage",
"type": "progene_text",
"text": [
"Expression of the IFN-kappa mRNA was observed in resting dendritic cells and monocytes , and it was up - regulated by IFN-gamma stimulation in monocytes , while IFN-beta mRNA was minimally detectable under the same conditions ."
],
"offsets": [
[
0,
227
]
]
}
]
| [
{
"id": "split_0_train_3769_entity",
"type": "progene_text",
"text": [
"IFN-kappa"
],
"offsets": [
[
18,
27
]
],
"normalized": []
},
{
"id": "split_0_train_3770_entity",
"type": "progene_text",
"text": [
"IFN-gamma"
],
"offsets": [
[
118,
127
]
],
"normalized": []
},
{
"id": "split_0_train_3771_entity",
"type": "progene_text",
"text": [
"IFN-beta"
],
"offsets": [
[
161,
169
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2470 | split_0_train_2470 | [
{
"id": "split_0_train_2470_passage",
"type": "progene_text",
"text": [
"Monocyte and dendritic cell expression of IFN-kappa was also confirmed in vivo in chronic lesions of psoriasis vulgaris and atopic dermatitis ."
],
"offsets": [
[
0,
143
]
]
}
]
| [
{
"id": "split_0_train_3772_entity",
"type": "progene_text",
"text": [
"IFN-kappa"
],
"offsets": [
[
42,
51
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2471 | split_0_train_2471 | [
{
"id": "split_0_train_2471_passage",
"type": "progene_text",
"text": [
"Finally , biosensor - based binding kinetic analysis revealed that IFN-kappa , like IFN-beta , binds strongly to heparin ( K(d) : 2.1 nM ) , suggesting that the cytokine can be retained close to the local site of production ."
],
"offsets": [
[
0,
225
]
]
}
]
| [
{
"id": "split_0_train_3773_entity",
"type": "progene_text",
"text": [
"IFN-kappa"
],
"offsets": [
[
67,
76
]
],
"normalized": []
},
{
"id": "split_0_train_3774_entity",
"type": "progene_text",
"text": [
"IFN-beta"
],
"offsets": [
[
84,
92
]
],
"normalized": []
},
{
"id": "split_0_train_3775_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
161,
169
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2472 | split_0_train_2472 | [
{
"id": "split_0_train_2472_passage",
"type": "progene_text",
"text": [
"The pattern of cytokines induced by IFN-kappa in monocytes , coupled with the unique induction of IFN-kappa mRNA by IFN-gamma , indicates a potential role for IFN-kappa in the regulation of immune cell functions ."
],
"offsets": [
[
0,
213
]
]
}
]
| [
{
"id": "split_0_train_3776_entity",
"type": "progene_text",
"text": [
"cytokines"
],
"offsets": [
[
15,
24
]
],
"normalized": []
},
{
"id": "split_0_train_3777_entity",
"type": "progene_text",
"text": [
"IFN-kappa"
],
"offsets": [
[
36,
45
]
],
"normalized": []
},
{
"id": "split_0_train_3778_entity",
"type": "progene_text",
"text": [
"IFN-kappa"
],
"offsets": [
[
98,
107
]
],
"normalized": []
},
{
"id": "split_0_train_3779_entity",
"type": "progene_text",
"text": [
"IFN-gamma"
],
"offsets": [
[
116,
125
]
],
"normalized": []
},
{
"id": "split_0_train_3780_entity",
"type": "progene_text",
"text": [
"IFN-kappa"
],
"offsets": [
[
159,
168
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2473 | split_0_train_2473 | [
{
"id": "split_0_train_2473_passage",
"type": "progene_text",
"text": [
"Differential roles of SOCS family members in EpoR signal transduction ."
],
"offsets": [
[
0,
71
]
]
}
]
| [
{
"id": "split_0_train_3781_entity",
"type": "progene_text",
"text": [
"SOCS family"
],
"offsets": [
[
22,
33
]
],
"normalized": []
},
{
"id": "split_0_train_3782_entity",
"type": "progene_text",
"text": [
"EpoR"
],
"offsets": [
[
45,
49
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2474 | split_0_train_2474 | [
{
"id": "split_0_train_2474_passage",
"type": "progene_text",
"text": [
"To elucidate the roles of suppressor of cytokine signaling ( SOCS ) family members in erythropoietin ( EPO ) signaling , we explored SOCS gene regulation , mRNA stability , and protein function in two EPO - responsive hematopoietic cell lines ."
],
"offsets": [
[
0,
244
]
]
}
]
| [
{
"id": "split_0_train_3783_entity",
"type": "progene_text",
"text": [
"suppressor of cytokine signaling ( SOCS ) family"
],
"offsets": [
[
26,
74
]
],
"normalized": []
},
{
"id": "split_0_train_3784_entity",
"type": "progene_text",
"text": [
"erythropoietin"
],
"offsets": [
[
86,
100
]
],
"normalized": []
},
{
"id": "split_0_train_3785_entity",
"type": "progene_text",
"text": [
"EPO"
],
"offsets": [
[
103,
106
]
],
"normalized": []
},
{
"id": "split_0_train_3786_entity",
"type": "progene_text",
"text": [
"SOCS"
],
"offsets": [
[
133,
137
]
],
"normalized": []
},
{
"id": "split_0_train_3787_entity",
"type": "progene_text",
"text": [
"EPO"
],
"offsets": [
[
201,
204
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2475 | split_0_train_2475 | [
{
"id": "split_0_train_2475_passage",
"type": "progene_text",
"text": [
"Using two independent approaches , one involving inhibition of specific signaling molecules and the other employing cell lines that express particular EpoR mutants and thereby activate only subsets of signaling cascades , we demonstrate that induction of SOCS1 , SOCS2 , SOCS3 , and cytokine - inducible SH2 - containing protein ( CIS ) in response to EPO stimulation appears to depend on Stat5 but not on mitogen - activated protein kinase ( MAPK ) or phosphatidylinositol 3-kinase ( PI3K ) ."
],
"offsets": [
[
0,
493
]
]
}
]
| [
{
"id": "split_0_train_3788_entity",
"type": "progene_text",
"text": [
"EpoR"
],
"offsets": [
[
151,
155
]
],
"normalized": []
},
{
"id": "split_0_train_3789_entity",
"type": "progene_text",
"text": [
"SOCS1"
],
"offsets": [
[
255,
260
]
],
"normalized": []
},
{
"id": "split_0_train_3790_entity",
"type": "progene_text",
"text": [
"SOCS2"
],
"offsets": [
[
263,
268
]
],
"normalized": []
},
{
"id": "split_0_train_3791_entity",
"type": "progene_text",
"text": [
"SOCS3"
],
"offsets": [
[
271,
276
]
],
"normalized": []
},
{
"id": "split_0_train_3792_entity",
"type": "progene_text",
"text": [
"cytokine - inducible SH2 - containing protein"
],
"offsets": [
[
283,
328
]
],
"normalized": []
},
{
"id": "split_0_train_3793_entity",
"type": "progene_text",
"text": [
"CIS"
],
"offsets": [
[
331,
334
]
],
"normalized": []
},
{
"id": "split_0_train_3794_entity",
"type": "progene_text",
"text": [
"EPO"
],
"offsets": [
[
352,
355
]
],
"normalized": []
},
{
"id": "split_0_train_3795_entity",
"type": "progene_text",
"text": [
"Stat5"
],
"offsets": [
[
389,
394
]
],
"normalized": []
},
{
"id": "split_0_train_3796_entity",
"type": "progene_text",
"text": [
"mitogen - activated protein kinase"
],
"offsets": [
[
406,
440
]
],
"normalized": []
},
{
"id": "split_0_train_3797_entity",
"type": "progene_text",
"text": [
"MAPK"
],
"offsets": [
[
443,
447
]
],
"normalized": []
},
{
"id": "split_0_train_3798_entity",
"type": "progene_text",
"text": [
"phosphatidylinositol 3-kinase"
],
"offsets": [
[
453,
482
]
],
"normalized": []
},
{
"id": "split_0_train_3799_entity",
"type": "progene_text",
"text": [
"PI3K"
],
"offsets": [
[
485,
489
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2476 | split_0_train_2476 | [
{
"id": "split_0_train_2476_passage",
"type": "progene_text",
"text": [
"SOCS4 expression , in contrast , does not appear to be EPO inducible ."
],
"offsets": [
[
0,
70
]
]
}
]
| [
{
"id": "split_0_train_3800_entity",
"type": "progene_text",
"text": [
"SOCS4"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "split_0_train_3801_entity",
"type": "progene_text",
"text": [
"EPO"
],
"offsets": [
[
55,
58
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2477 | split_0_train_2477 | [
{
"id": "split_0_train_2477_passage",
"type": "progene_text",
"text": [
"Furthermore , we show differential stabilities of SOCS transcripts , with SOCS2 the longest - lived and SOCS1 and CIS the least stable , and provide evidence in support of EPO - independent expression of SOCS3 and SOCS4 ."
],
"offsets": [
[
0,
221
]
]
}
]
| [
{
"id": "split_0_train_3802_entity",
"type": "progene_text",
"text": [
"SOCS"
],
"offsets": [
[
50,
54
]
],
"normalized": []
},
{
"id": "split_0_train_3803_entity",
"type": "progene_text",
"text": [
"SOCS2"
],
"offsets": [
[
74,
79
]
],
"normalized": []
},
{
"id": "split_0_train_3804_entity",
"type": "progene_text",
"text": [
"SOCS1"
],
"offsets": [
[
104,
109
]
],
"normalized": []
},
{
"id": "split_0_train_3805_entity",
"type": "progene_text",
"text": [
"CIS"
],
"offsets": [
[
114,
117
]
],
"normalized": []
},
{
"id": "split_0_train_3806_entity",
"type": "progene_text",
"text": [
"EPO"
],
"offsets": [
[
172,
175
]
],
"normalized": []
},
{
"id": "split_0_train_3807_entity",
"type": "progene_text",
"text": [
"SOCS3"
],
"offsets": [
[
204,
209
]
],
"normalized": []
},
{
"id": "split_0_train_3808_entity",
"type": "progene_text",
"text": [
"SOCS4"
],
"offsets": [
[
214,
219
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2478 | split_0_train_2478 | [
{
"id": "split_0_train_2478_passage",
"type": "progene_text",
"text": [
"In order to understand the effects of SOCS on EPO - mediated effects , we generated multiple stable cell lines that inducibly express particular SOCS proteins ."
],
"offsets": [
[
0,
160
]
]
}
]
| [
{
"id": "split_0_train_3809_entity",
"type": "progene_text",
"text": [
"SOCS"
],
"offsets": [
[
38,
42
]
],
"normalized": []
},
{
"id": "split_0_train_3810_entity",
"type": "progene_text",
"text": [
"EPO"
],
"offsets": [
[
46,
49
]
],
"normalized": []
},
{
"id": "split_0_train_3811_entity",
"type": "progene_text",
"text": [
"SOCS"
],
"offsets": [
[
145,
149
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2479 | split_0_train_2479 | [
{
"id": "split_0_train_2479_passage",
"type": "progene_text",
"text": [
"Overexpression of SOCS1 , SOCS3 , or CIS negatively regulates EPO - mediated cell proliferation Stat5 phosphorylation , and activation of a Stat - dependent luciferase reporter ."
],
"offsets": [
[
0,
178
]
]
}
]
| [
{
"id": "split_0_train_3812_entity",
"type": "progene_text",
"text": [
"SOCS1"
],
"offsets": [
[
18,
23
]
],
"normalized": []
},
{
"id": "split_0_train_3813_entity",
"type": "progene_text",
"text": [
"SOCS3"
],
"offsets": [
[
26,
31
]
],
"normalized": []
},
{
"id": "split_0_train_3814_entity",
"type": "progene_text",
"text": [
"CIS"
],
"offsets": [
[
37,
40
]
],
"normalized": []
},
{
"id": "split_0_train_3815_entity",
"type": "progene_text",
"text": [
"EPO"
],
"offsets": [
[
62,
65
]
],
"normalized": []
},
{
"id": "split_0_train_3816_entity",
"type": "progene_text",
"text": [
"Stat5"
],
"offsets": [
[
96,
101
]
],
"normalized": []
},
{
"id": "split_0_train_3817_entity",
"type": "progene_text",
"text": [
"Stat"
],
"offsets": [
[
140,
144
]
],
"normalized": []
},
{
"id": "split_0_train_3818_entity",
"type": "progene_text",
"text": [
"luciferase"
],
"offsets": [
[
157,
167
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2480 | split_0_train_2480 | [
{
"id": "split_0_train_2480_passage",
"type": "progene_text",
"text": [
"In contrast , SOCS2 is less effective , and SOCS4 is ineffective at counteracting EPO - mediated events ."
],
"offsets": [
[
0,
105
]
]
}
]
| [
{
"id": "split_0_train_3819_entity",
"type": "progene_text",
"text": [
"SOCS2"
],
"offsets": [
[
14,
19
]
],
"normalized": []
},
{
"id": "split_0_train_3820_entity",
"type": "progene_text",
"text": [
"SOCS4"
],
"offsets": [
[
44,
49
]
],
"normalized": []
},
{
"id": "split_0_train_3821_entity",
"type": "progene_text",
"text": [
"EPO"
],
"offsets": [
[
82,
85
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2481 | split_0_train_2481 | [
{
"id": "split_0_train_2481_passage",
"type": "progene_text",
"text": [
"Thus , we have demonstrated differential regulation and function of various SOCS family members in EPO - dependent hematopoietic cells ."
],
"offsets": [
[
0,
136
]
]
}
]
| [
{
"id": "split_0_train_3822_entity",
"type": "progene_text",
"text": [
"SOCS family"
],
"offsets": [
[
76,
87
]
],
"normalized": []
},
{
"id": "split_0_train_3823_entity",
"type": "progene_text",
"text": [
"EPO"
],
"offsets": [
[
99,
102
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2482 | split_0_train_2482 | [
{
"id": "split_0_train_2482_passage",
"type": "progene_text",
"text": [
"Altered biological activity associated with C - terminal modifications of IL-7 ."
],
"offsets": [
[
0,
80
]
]
}
]
| [
{
"id": "split_0_train_3824_entity",
"type": "progene_text",
"text": [
"IL-7"
],
"offsets": [
[
74,
78
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2483 | split_0_train_2483 | [
{
"id": "split_0_train_2483_passage",
"type": "progene_text",
"text": [
"Interleukin 7 ( IL-7 ) is a pleiotropic cytokine which plays a role in both T and B cell function as well as in establishment and maintenance of immunological barriers in epithelial tissues ."
],
"offsets": [
[
0,
191
]
]
}
]
| [
{
"id": "split_0_train_3825_entity",
"type": "progene_text",
"text": [
"Interleukin 7"
],
"offsets": [
[
0,
13
]
],
"normalized": []
},
{
"id": "split_0_train_3826_entity",
"type": "progene_text",
"text": [
"IL-7"
],
"offsets": [
[
16,
20
]
],
"normalized": []
},
{
"id": "split_0_train_3827_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
40,
48
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2484 | split_0_train_2484 | [
{
"id": "split_0_train_2484_passage",
"type": "progene_text",
"text": [
"The heterodimeric IL-7 receptor ( IL-7R ) consists of the p76 IL-7Ralpha subunit and the p64 common gamma ( gammac ) subunit ."
],
"offsets": [
[
0,
126
]
]
}
]
| [
{
"id": "split_0_train_3828_entity",
"type": "progene_text",
"text": [
"IL-7 receptor"
],
"offsets": [
[
18,
31
]
],
"normalized": []
},
{
"id": "split_0_train_3829_entity",
"type": "progene_text",
"text": [
"IL-7R"
],
"offsets": [
[
34,
39
]
],
"normalized": []
},
{
"id": "split_0_train_3830_entity",
"type": "progene_text",
"text": [
"IL-7Ralpha"
],
"offsets": [
[
62,
72
]
],
"normalized": []
},
{
"id": "split_0_train_3831_entity",
"type": "progene_text",
"text": [
"p64 common gamma"
],
"offsets": [
[
89,
105
]
],
"normalized": []
},
{
"id": "split_0_train_3832_entity",
"type": "progene_text",
"text": [
"gammac"
],
"offsets": [
[
108,
114
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2485 | split_0_train_2485 | [
{
"id": "split_0_train_2485_passage",
"type": "progene_text",
"text": [
"Ligand - binding induces signal transduction through tyrosine phosphorylation of the janus ( Jak ) and src - related kinases as well as by activation of phosphatidinositol-3 kinase ( P13-kinase ) ."
],
"offsets": [
[
0,
197
]
]
}
]
| [
{
"id": "split_0_train_3833_entity",
"type": "progene_text",
"text": [
"janus ( Jak ) and src - related kinases"
],
"offsets": [
[
85,
124
]
],
"normalized": []
},
{
"id": "split_0_train_3834_entity",
"type": "progene_text",
"text": [
"phosphatidinositol-3 kinase"
],
"offsets": [
[
153,
180
]
],
"normalized": []
},
{
"id": "split_0_train_3835_entity",
"type": "progene_text",
"text": [
"P13-kinase"
],
"offsets": [
[
183,
193
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2486 | split_0_train_2486 | [
{
"id": "split_0_train_2486_passage",
"type": "progene_text",
"text": [
"In an effort to further define the requirements for ligand - receptor interactions and to subsequently develop candidate receptor binding antagonists with selective biological activities , we examined a series of IL-7 mutants in which the carboxy terminal hydrophobic residues were substituted with aliphatic amino acids ."
],
"offsets": [
[
0,
322
]
]
}
]
| [
{
"id": "split_0_train_3836_entity",
"type": "progene_text",
"text": [
"IL-7"
],
"offsets": [
[
213,
217
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2487 | split_0_train_2487 | [
{
"id": "split_0_train_2487_passage",
"type": "progene_text",
"text": [
"In this study we describe abrogation of IL-7 driven proliferation and attenuated phosphotyrosine signaling by IL-7 (143) ( Trp-Ala ) and IL-7 (143) ( Trp-His ) in IL-7R expressing T and B leukemia cells ."
],
"offsets": [
[
0,
204
]
]
}
]
| [
{
"id": "split_0_train_3837_entity",
"type": "progene_text",
"text": [
"IL-7"
],
"offsets": [
[
40,
44
]
],
"normalized": []
},
{
"id": "split_0_train_3838_entity",
"type": "progene_text",
"text": [
"IL-7"
],
"offsets": [
[
110,
114
]
],
"normalized": []
},
{
"id": "split_0_train_3839_entity",
"type": "progene_text",
"text": [
"IL-7"
],
"offsets": [
[
137,
141
]
],
"normalized": []
},
{
"id": "split_0_train_3840_entity",
"type": "progene_text",
"text": [
"IL-7R"
],
"offsets": [
[
163,
168
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2488 | split_0_train_2488 | [
{
"id": "split_0_train_2488_passage",
"type": "progene_text",
"text": [
"Decreased phosphorylation of Jak3 kinase by IL-7W143A , IL-7W143P and IL-7W143H suggest that alterations in this region of the carboxyterminal region of IL-7 affects its interaction with the gammac subunit of the IL-7R ."
],
"offsets": [
[
0,
220
]
]
}
]
| [
{
"id": "split_0_train_3841_entity",
"type": "progene_text",
"text": [
"Jak3"
],
"offsets": [
[
29,
33
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],
"normalized": []
},
{
"id": "split_0_train_3842_entity",
"type": "progene_text",
"text": [
"kinase"
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[
34,
40
]
],
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},
{
"id": "split_0_train_3843_entity",
"type": "progene_text",
"text": [
"IL-7W143A"
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"offsets": [
[
44,
53
]
],
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},
{
"id": "split_0_train_3844_entity",
"type": "progene_text",
"text": [
"IL-7W143P"
],
"offsets": [
[
56,
65
]
],
"normalized": []
},
{
"id": "split_0_train_3845_entity",
"type": "progene_text",
"text": [
"IL-7W143H"
],
"offsets": [
[
70,
79
]
],
"normalized": []
},
{
"id": "split_0_train_3846_entity",
"type": "progene_text",
"text": [
"IL-7"
],
"offsets": [
[
153,
157
]
],
"normalized": []
},
{
"id": "split_0_train_3847_entity",
"type": "progene_text",
"text": [
"gammac"
],
"offsets": [
[
191,
197
]
],
"normalized": []
},
{
"id": "split_0_train_3848_entity",
"type": "progene_text",
"text": [
"IL-7R"
],
"offsets": [
[
213,
218
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2489 | split_0_train_2489 | [
{
"id": "split_0_train_2489_passage",
"type": "progene_text",
"text": [
"Interleukin-15 interactions with interleukin-15 receptor complexes : characterization and species specificity ."
],
"offsets": [
[
0,
111
]
]
}
]
| [
{
"id": "split_0_train_3849_entity",
"type": "progene_text",
"text": [
"Interleukin-15"
],
"offsets": [
[
0,
14
]
],
"normalized": []
},
{
"id": "split_0_train_3850_entity",
"type": "progene_text",
"text": [
"interleukin-15 receptor"
],
"offsets": [
[
33,
56
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2490 | split_0_train_2490 | [
{
"id": "split_0_train_2490_passage",
"type": "progene_text",
"text": [
"Interleukin ( IL-) 2 and IL-15 share the IL-2 receptor betagamma c subunits ( IL-2Rbetagamma c ) but have specific , unique alpha receptor subunits ."
],
"offsets": [
[
0,
149
]
]
}
]
| [
{
"id": "split_0_train_3851_entity",
"type": "progene_text",
"text": [
"Interleukin ( IL-) 2"
],
"offsets": [
[
0,
20
]
],
"normalized": []
},
{
"id": "split_0_train_3852_entity",
"type": "progene_text",
"text": [
"IL-15"
],
"offsets": [
[
25,
30
]
],
"normalized": []
},
{
"id": "split_0_train_3853_entity",
"type": "progene_text",
"text": [
"IL-2 receptor betagamma c"
],
"offsets": [
[
41,
66
]
],
"normalized": []
},
{
"id": "split_0_train_3854_entity",
"type": "progene_text",
"text": [
"IL-2Rbetagamma c"
],
"offsets": [
[
78,
94
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2491 | split_0_train_2491 | [
{
"id": "split_0_train_2491_passage",
"type": "progene_text",
"text": [
"We studied species specificity of human ( hu ) , simian ( si ) , and mouse ( mu ) IL-15 and found that hu and si IL-15 behaved similarly in all systems investigated ."
],
"offsets": [
[
0,
166
]
]
}
]
| [
{
"id": "split_0_train_3855_entity",
"type": "progene_text",
"text": [
"IL-15"
],
"offsets": [
[
82,
87
]
],
"normalized": []
},
{
"id": "split_0_train_3856_entity",
"type": "progene_text",
"text": [
"IL-15"
],
"offsets": [
[
113,
118
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2492 | split_0_train_2492 | [
{
"id": "split_0_train_2492_passage",
"type": "progene_text",
"text": [
"Hu and mu IL-15 bound hu or mu IL-15Ralpha with equal high affinity in the presence or absence of IL-2Rbetagamma c and exhibited similar proliferative activities on cells containing all three subunits ."
],
"offsets": [
[
0,
202
]
]
}
]
| [
{
"id": "split_0_train_3857_entity",
"type": "progene_text",
"text": [
"IL-15"
],
"offsets": [
[
10,
15
]
],
"normalized": []
},
{
"id": "split_0_train_3858_entity",
"type": "progene_text",
"text": [
"IL-15Ralpha"
],
"offsets": [
[
31,
42
]
],
"normalized": []
},
{
"id": "split_0_train_3859_entity",
"type": "progene_text",
"text": [
"IL-2Rbetagamma c"
],
"offsets": [
[
98,
114
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2493 | split_0_train_2493 | [
{
"id": "split_0_train_2493_passage",
"type": "progene_text",
"text": [
"However , quantitative differences were noted in the specific activity of hu and mu IL-15 in both in vitro and in vivo systems utilizing IL-2Rbetagamma c in the absence of IL-15Ralpha ."
],
"offsets": [
[
0,
185
]
]
}
]
| [
{
"id": "split_0_train_3860_entity",
"type": "progene_text",
"text": [
"IL-15"
],
"offsets": [
[
84,
89
]
],
"normalized": []
},
{
"id": "split_0_train_3861_entity",
"type": "progene_text",
"text": [
"IL-2Rbetagamma c"
],
"offsets": [
[
137,
153
]
],
"normalized": []
},
{
"id": "split_0_train_3862_entity",
"type": "progene_text",
"text": [
"IL-15Ralpha"
],
"offsets": [
[
172,
183
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2494 | split_0_train_2494 | [
{
"id": "split_0_train_2494_passage",
"type": "progene_text",
"text": [
"These data show that hu IL-15 may be used in mouse model systems , however care must be taken when comparing the efficacy and toxicity of cytokines across species ."
],
"offsets": [
[
0,
164
]
]
}
]
| [
{
"id": "split_0_train_3863_entity",
"type": "progene_text",
"text": [
"IL-15"
],
"offsets": [
[
24,
29
]
],
"normalized": []
},
{
"id": "split_0_train_3864_entity",
"type": "progene_text",
"text": [
"cytokines"
],
"offsets": [
[
138,
147
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2495 | split_0_train_2495 | [
{
"id": "split_0_train_2495_passage",
"type": "progene_text",
"text": [
"Identification of oligomerization and drug - binding domains of the membrane fusion protein EmrA ."
],
"offsets": [
[
0,
98
]
]
}
]
| [
{
"id": "split_0_train_3865_entity",
"type": "progene_text",
"text": [
"EmrA"
],
"offsets": [
[
92,
96
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2496 | split_0_train_2496 | [
{
"id": "split_0_train_2496_passage",
"type": "progene_text",
"text": [
"Many pathogenic Gram - negative bacteria possess tripartite transporters that catalyze drug extrusion across the inner and outer membranes , thereby conferring resistance ."
],
"offsets": [
[
0,
172
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2497 | split_0_train_2497 | [
{
"id": "split_0_train_2497_passage",
"type": "progene_text",
"text": [
"These transporters consist of inner ( IMP ) and outer ( OMP ) membrane proteins , which are coupled by a periplasmic membrane fusion ( MFP ) protein ."
],
"offsets": [
[
0,
150
]
]
}
]
| [
{
"id": "split_0_train_3866_entity",
"type": "progene_text",
"text": [
"membrane fusion ( MFP ) protein"
],
"offsets": [
[
117,
148
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2498 | split_0_train_2498 | [
{
"id": "split_0_train_2498_passage",
"type": "progene_text",
"text": [
"However , it is not know whether the MFP translocates the drug between the membranes , by acting as a channel , or whether it brings the IMP and OMP together , facilitating drug transfer ."
],
"offsets": [
[
0,
188
]
]
}
]
| [
{
"id": "split_0_train_3867_entity",
"type": "progene_text",
"text": [
"MFP"
],
"offsets": [
[
37,
40
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2499 | split_0_train_2499 | [
{
"id": "split_0_train_2499_passage",
"type": "progene_text",
"text": [
"The MFP EmrA has an elongated periplasmic domain , which binds transported drugs , and is anchored to the inner membrane by a single alpha-helix , which contains a leucine zipper dimerization domain ."
],
"offsets": [
[
0,
200
]
]
}
]
| [
{
"id": "split_0_train_3868_entity",
"type": "progene_text",
"text": [
"MFP"
],
"offsets": [
[
4,
7
]
],
"normalized": []
},
{
"id": "split_0_train_3869_entity",
"type": "progene_text",
"text": [
"EmrA"
],
"offsets": [
[
8,
12
]
],
"normalized": []
}
]
| []
| []
| []
|
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