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stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
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|---|---|---|---|---|---|---|
split_0_train_2600 | split_0_train_2600 | [
{
"id": "split_0_train_2600_passage",
"type": "progene_text",
"text": [
"Escherichia coli 3-deoxy-D-manno-octulosonate 8-phosphate ( KDO8-P ) synthase is able to utilize the five - carbon phosphorylated monosaccharide , 2-deoxyribose 5-phosphate ( 2dR5P ) , as an alternate substrate , but not D-ribose 5-phosphate ( R5P ) nor the four carbon analogue D-erythrose 4 - phosphate ( E4P ) ."
],
"offsets": [
[
0,
314
]
]
}
]
| [
{
"id": "split_0_train_4041_entity",
"type": "progene_text",
"text": [
"3-deoxy-D-manno-octulosonate 8-phosphate ( KDO8-P ) synthase"
],
"offsets": [
[
17,
77
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2601 | split_0_train_2601 | [
{
"id": "split_0_train_2601_passage",
"type": "progene_text",
"text": [
"However , E. coli KDO8-P synthase in the presence of either R5P or E4P catalyzes the rapid consumption of approximately 1 mol of PEP per active site , after which consumption of PEP slows to a negligible but measurable rate ."
],
"offsets": [
[
0,
225
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]
}
]
| [
{
"id": "split_0_train_4042_entity",
"type": "progene_text",
"text": [
"KDO8-P synthase"
],
"offsets": [
[
18,
33
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2602 | split_0_train_2602 | [
{
"id": "split_0_train_2602_passage",
"type": "progene_text",
"text": [
"The mechanism of this abortive utilization of PEP was investigated using [2,3-(13)C(2)]-PEP and [3-F]-PEP , and the reaction products were determined by ( 13 ) C , ( 31 ) P , and (19)F NMR to be pyruvate , phosphate , and 2-phosphoglyceric acid ( 2-PGA ) ."
],
"offsets": [
[
0,
256
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2603 | split_0_train_2603 | [
{
"id": "split_0_train_2603_passage",
"type": "progene_text",
"text": [
"The formation of pyruvate and 2-PGA suggests that the reaction catalyzed by KDO8-P synthase may be initiated via a nucleophilic attack to PEP by a water molecule ."
],
"offsets": [
[
0,
163
]
]
}
]
| [
{
"id": "split_0_train_4043_entity",
"type": "progene_text",
"text": [
"KDO8-P synthase"
],
"offsets": [
[
76,
91
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2604 | split_0_train_2604 | [
{
"id": "split_0_train_2604_passage",
"type": "progene_text",
"text": [
"In experiments in which the homologous enzyme , 3-deoxy-D-arabino-heptulosonate 7-phosphate ( DAH7-P ) synthase was incubated with D,L-glyceraldehyde 3-phosphate ( G3P ) and [2,3-(13)C(2)]-PEP , pyruvate and phosphate were the predominant species formed , suggesting that the reaction catalyzed by DAH7-P synthase starts with a nucleophilic attack by water onto PEP as observed in E. coli KDO8-P synthase ."
],
"offsets": [
[
0,
406
]
]
}
]
| [
{
"id": "split_0_train_4044_entity",
"type": "progene_text",
"text": [
"3-deoxy-D-arabino-heptulosonate 7-phosphate ( DAH7-P ) synthase"
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"offsets": [
[
48,
111
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],
"normalized": []
},
{
"id": "split_0_train_4045_entity",
"type": "progene_text",
"text": [
"DAH7-P synthase"
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"offsets": [
[
298,
313
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],
"normalized": []
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{
"id": "split_0_train_4046_entity",
"type": "progene_text",
"text": [
"KDO8-P synthase"
],
"offsets": [
[
389,
404
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2605 | split_0_train_2605 | [
{
"id": "split_0_train_2605_passage",
"type": "progene_text",
"text": [
"Insulin resistance and lipodystrophy in mice lacking ribosomal S6 kinase 2 ."
],
"offsets": [
[
0,
76
]
]
}
]
| [
{
"id": "split_0_train_4047_entity",
"type": "progene_text",
"text": [
"Insulin"
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"offsets": [
[
0,
7
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"normalized": []
},
{
"id": "split_0_train_4048_entity",
"type": "progene_text",
"text": [
"ribosomal S6 kinase 2"
],
"offsets": [
[
53,
74
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2606 | split_0_train_2606 | [
{
"id": "split_0_train_2606_passage",
"type": "progene_text",
"text": [
"The p90 ribosomal S6 kinase 2 ( RSK2 ) is a serine / threonine kinase with high expression levels in adipose tissue ."
],
"offsets": [
[
0,
117
]
]
}
]
| [
{
"id": "split_0_train_4049_entity",
"type": "progene_text",
"text": [
"p90 ribosomal S6 kinase 2"
],
"offsets": [
[
4,
29
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],
"normalized": []
},
{
"id": "split_0_train_4050_entity",
"type": "progene_text",
"text": [
"RSK2"
],
"offsets": [
[
32,
36
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],
"normalized": []
},
{
"id": "split_0_train_4051_entity",
"type": "progene_text",
"text": [
"serine / threonine kinase"
],
"offsets": [
[
44,
69
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2607 | split_0_train_2607 | [
{
"id": "split_0_train_2607_passage",
"type": "progene_text",
"text": [
"Numerous in vitro studies show that RSK2 is activated by a broad number of cellular stimuli and suggest that RSK2 is involved in the regulation of a variety of cellular processes ."
],
"offsets": [
[
0,
180
]
]
}
]
| [
{
"id": "split_0_train_4052_entity",
"type": "progene_text",
"text": [
"RSK2"
],
"offsets": [
[
36,
40
]
],
"normalized": []
},
{
"id": "split_0_train_4053_entity",
"type": "progene_text",
"text": [
"RSK2"
],
"offsets": [
[
109,
113
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2608 | split_0_train_2608 | [
{
"id": "split_0_train_2608_passage",
"type": "progene_text",
"text": [
"However , the physiological role of RSK2 still remains elusive ."
],
"offsets": [
[
0,
64
]
]
}
]
| [
{
"id": "split_0_train_4054_entity",
"type": "progene_text",
"text": [
"RSK2"
],
"offsets": [
[
36,
40
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2609 | split_0_train_2609 | [
{
"id": "split_0_train_2609_passage",
"type": "progene_text",
"text": [
"We therefore generated rsk2 knockout ( KO ) mice to better understand the function of RSK2 in vivo ."
],
"offsets": [
[
0,
100
]
]
}
]
| [
{
"id": "split_0_train_4055_entity",
"type": "progene_text",
"text": [
"rsk2"
],
"offsets": [
[
23,
27
]
],
"normalized": []
},
{
"id": "split_0_train_4056_entity",
"type": "progene_text",
"text": [
"RSK2"
],
"offsets": [
[
86,
90
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2610 | split_0_train_2610 | [
{
"id": "split_0_train_2610_passage",
"type": "progene_text",
"text": [
"Birth weights of RSK2 KO mice are normal , but the body weight is reduced with age , as compared with wild - type littermates ."
],
"offsets": [
[
0,
127
]
]
}
]
| [
{
"id": "split_0_train_4057_entity",
"type": "progene_text",
"text": [
"RSK2"
],
"offsets": [
[
17,
21
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2611 | split_0_train_2611 | [
{
"id": "split_0_train_2611_passage",
"type": "progene_text",
"text": [
"We found that the difference in body weight was largely caused by a specific loss of white adipose tissue that is accompanied by reduced serum levels of the adipocyte - derived peptide , leptin ."
],
"offsets": [
[
0,
195
]
]
}
]
| [
{
"id": "split_0_train_4058_entity",
"type": "progene_text",
"text": [
"leptin"
],
"offsets": [
[
187,
193
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2612 | split_0_train_2612 | [
{
"id": "split_0_train_2612_passage",
"type": "progene_text",
"text": [
"KO mice also have impaired glucose tolerance and elevated fasting insulin and glucose levels that are restored following administration of low amounts of leptin , which do not affect food intake ."
],
"offsets": [
[
0,
196
]
]
}
]
| [
{
"id": "split_0_train_4059_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
66,
73
]
],
"normalized": []
},
{
"id": "split_0_train_4060_entity",
"type": "progene_text",
"text": [
"leptin"
],
"offsets": [
[
154,
160
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2613 | split_0_train_2613 | [
{
"id": "split_0_train_2613_passage",
"type": "progene_text",
"text": [
"We conclude that RSK2 plays a novel and an important role in regulation of adipose mass in mice and speculate that the reduction in fat tissue may negatively affect insulin sensitivity , as observed in human lipodystrophy , through reduced levels of adipocyte - derived factors , such as leptin ."
],
"offsets": [
[
0,
296
]
]
}
]
| [
{
"id": "split_0_train_4061_entity",
"type": "progene_text",
"text": [
"RSK2"
],
"offsets": [
[
17,
21
]
],
"normalized": []
},
{
"id": "split_0_train_4062_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
165,
172
]
],
"normalized": []
},
{
"id": "split_0_train_4063_entity",
"type": "progene_text",
"text": [
"leptin"
],
"offsets": [
[
288,
294
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2614 | split_0_train_2614 | [
{
"id": "split_0_train_2614_passage",
"type": "progene_text",
"text": [
"Cloning of TRAP , a ligand for CD40 on human T cells ."
],
"offsets": [
[
0,
54
]
]
}
]
| [
{
"id": "split_0_train_4064_entity",
"type": "progene_text",
"text": [
"TRAP"
],
"offsets": [
[
11,
15
]
],
"normalized": []
},
{
"id": "split_0_train_4065_entity",
"type": "progene_text",
"text": [
"CD40"
],
"offsets": [
[
31,
35
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2615 | split_0_train_2615 | [
{
"id": "split_0_train_2615_passage",
"type": "progene_text",
"text": [
"A cDNA clone , designated TRAP ( TNF - related activation protein ) was isolated from a collection of T cell activation genes ."
],
"offsets": [
[
0,
127
]
]
}
]
| [
{
"id": "split_0_train_4066_entity",
"type": "progene_text",
"text": [
"TRAP"
],
"offsets": [
[
26,
30
]
],
"normalized": []
},
{
"id": "split_0_train_4067_entity",
"type": "progene_text",
"text": [
"TNF - related activation protein"
],
"offsets": [
[
33,
65
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2616 | split_0_train_2616 | [
{
"id": "split_0_train_2616_passage",
"type": "progene_text",
"text": [
"The polypeptide encoded by a mRNA of approx. 2.3 kb is 261 amino acids long with a calculated M(r) of 29.3 kDa ."
],
"offsets": [
[
0,
112
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2617 | split_0_train_2617 | [
{
"id": "split_0_train_2617_passage",
"type": "progene_text",
"text": [
"The structural features predict a type II transmembrane protein , but are also compatible with a secreted form ."
],
"offsets": [
[
0,
112
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2618 | split_0_train_2618 | [
{
"id": "split_0_train_2618_passage",
"type": "progene_text",
"text": [
"TRAP is highly similar to an identified murine CD40 ligand both at the cDNA ( 82.8 % identity ) and the protein ( 77.4 % identity ) levels , and related to tumor necrosis factor / lymphotoxin ."
],
"offsets": [
[
0,
193
]
]
}
]
| [
{
"id": "split_0_train_4068_entity",
"type": "progene_text",
"text": [
"TRAP"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_4069_entity",
"type": "progene_text",
"text": [
"CD40 ligand"
],
"offsets": [
[
47,
58
]
],
"normalized": []
},
{
"id": "split_0_train_4070_entity",
"type": "progene_text",
"text": [
"tumor necrosis factor"
],
"offsets": [
[
156,
177
]
],
"normalized": []
},
{
"id": "split_0_train_4071_entity",
"type": "progene_text",
"text": [
"lymphotoxin"
],
"offsets": [
[
180,
191
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2619 | split_0_train_2619 | [
{
"id": "split_0_train_2619_passage",
"type": "progene_text",
"text": [
"Expressed in a murine myeloma , TRAP was identified as a ligand for CD40 by binding to a soluble CD40 construct ."
],
"offsets": [
[
0,
113
]
]
}
]
| [
{
"id": "split_0_train_4072_entity",
"type": "progene_text",
"text": [
"TRAP"
],
"offsets": [
[
32,
36
]
],
"normalized": []
},
{
"id": "split_0_train_4073_entity",
"type": "progene_text",
"text": [
"CD40"
],
"offsets": [
[
68,
72
]
],
"normalized": []
},
{
"id": "split_0_train_4074_entity",
"type": "progene_text",
"text": [
"CD40"
],
"offsets": [
[
97,
101
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2620 | split_0_train_2620 | [
{
"id": "split_0_train_2620_passage",
"type": "progene_text",
"text": [
"TRAP mRNA is expressed in a T cell - specific fashion with a maximum at 8 h after stimulation ."
],
"offsets": [
[
0,
95
]
]
}
]
| [
{
"id": "split_0_train_4075_entity",
"type": "progene_text",
"text": [
"TRAP"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2621 | split_0_train_2621 | [
{
"id": "split_0_train_2621_passage",
"type": "progene_text",
"text": [
"The TRAP gene is located in the q26.3 - q27.1 region of the X chromosome ."
],
"offsets": [
[
0,
74
]
]
}
]
| [
{
"id": "split_0_train_4076_entity",
"type": "progene_text",
"text": [
"TRAP"
],
"offsets": [
[
4,
8
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2622 | split_0_train_2622 | [
{
"id": "split_0_train_2622_passage",
"type": "progene_text",
"text": [
"IRAK - dependent phosphorylation of Stat1 on serine 727 in response to interleukin-1 and effects on gene expression ."
],
"offsets": [
[
0,
117
]
]
}
]
| [
{
"id": "split_0_train_4077_entity",
"type": "progene_text",
"text": [
"IRAK"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_4078_entity",
"type": "progene_text",
"text": [
"Stat1"
],
"offsets": [
[
36,
41
]
],
"normalized": []
},
{
"id": "split_0_train_4079_entity",
"type": "progene_text",
"text": [
"interleukin-1"
],
"offsets": [
[
71,
84
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2623 | split_0_train_2623 | [
{
"id": "split_0_train_2623_passage",
"type": "progene_text",
"text": [
"Interleukin-1 ( IL-1 ) induces the phosphorylation of Stat1 on serine 727 but not on tyrosine 701 ."
],
"offsets": [
[
0,
99
]
]
}
]
| [
{
"id": "split_0_train_4080_entity",
"type": "progene_text",
"text": [
"Interleukin-1"
],
"offsets": [
[
0,
13
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],
"normalized": []
},
{
"id": "split_0_train_4081_entity",
"type": "progene_text",
"text": [
"IL-1"
],
"offsets": [
[
16,
20
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],
"normalized": []
},
{
"id": "split_0_train_4082_entity",
"type": "progene_text",
"text": [
"Stat1"
],
"offsets": [
[
54,
59
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2624 | split_0_train_2624 | [
{
"id": "split_0_train_2624_passage",
"type": "progene_text",
"text": [
"Analyses of mutant I1A cells , which lack the IL-1 receptor - associated kinase ( IRAK ) , and of I1A cells reconstituted with deletion mutants of IRAK show that the IL-1 - mediated phosphorylation of Stat1 on serine requires the IRAK protein but not its kinase activity and does not involve phosphatidylinositol-3'-kinase ( PI3K ) or the mitogen - activated protein ( MAP ) kinases p38 or ERK ."
],
"offsets": [
[
0,
395
]
]
}
]
| [
{
"id": "split_0_train_4083_entity",
"type": "progene_text",
"text": [
"IL-1 receptor - associated kinase"
],
"offsets": [
[
46,
79
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],
"normalized": []
},
{
"id": "split_0_train_4084_entity",
"type": "progene_text",
"text": [
"IRAK"
],
"offsets": [
[
82,
86
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],
"normalized": []
},
{
"id": "split_0_train_4085_entity",
"type": "progene_text",
"text": [
"IRAK"
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"offsets": [
[
147,
151
]
],
"normalized": []
},
{
"id": "split_0_train_4086_entity",
"type": "progene_text",
"text": [
"IL-1"
],
"offsets": [
[
166,
170
]
],
"normalized": []
},
{
"id": "split_0_train_4087_entity",
"type": "progene_text",
"text": [
"Stat1"
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[
201,
206
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],
"normalized": []
},
{
"id": "split_0_train_4088_entity",
"type": "progene_text",
"text": [
"IRAK"
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"offsets": [
[
230,
234
]
],
"normalized": []
},
{
"id": "split_0_train_4089_entity",
"type": "progene_text",
"text": [
"kinase"
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[
255,
261
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],
"normalized": []
},
{
"id": "split_0_train_4090_entity",
"type": "progene_text",
"text": [
"phosphatidylinositol-3'-kinase"
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[
292,
322
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],
"normalized": []
},
{
"id": "split_0_train_4091_entity",
"type": "progene_text",
"text": [
"PI3K"
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[
325,
329
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],
"normalized": []
},
{
"id": "split_0_train_4092_entity",
"type": "progene_text",
"text": [
"mitogen - activated protein ( MAP ) kinases"
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339,
382
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},
{
"id": "split_0_train_4093_entity",
"type": "progene_text",
"text": [
"p38"
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383,
386
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},
{
"id": "split_0_train_4094_entity",
"type": "progene_text",
"text": [
"ERK"
],
"offsets": [
[
390,
393
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2625 | split_0_train_2625 | [
{
"id": "split_0_train_2625_passage",
"type": "progene_text",
"text": [
"IRAK and Stat1 interact in vivo , and this interaction is increased in response to IL-1 , suggesting that IRAK may serve to recruit the as yet unknown IL-1 - induced Stat1 serine kinase ."
],
"offsets": [
[
0,
187
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]
}
]
| [
{
"id": "split_0_train_4095_entity",
"type": "progene_text",
"text": [
"IRAK"
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0,
4
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},
{
"id": "split_0_train_4096_entity",
"type": "progene_text",
"text": [
"Stat1"
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[
9,
14
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],
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},
{
"id": "split_0_train_4097_entity",
"type": "progene_text",
"text": [
"IL-1"
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[
83,
87
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],
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},
{
"id": "split_0_train_4098_entity",
"type": "progene_text",
"text": [
"IRAK"
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[
106,
110
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},
{
"id": "split_0_train_4099_entity",
"type": "progene_text",
"text": [
"IL-1"
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[
151,
155
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},
{
"id": "split_0_train_4100_entity",
"type": "progene_text",
"text": [
"Stat1"
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[
166,
171
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"normalized": []
},
{
"id": "split_0_train_4101_entity",
"type": "progene_text",
"text": [
"serine kinase"
],
"offsets": [
[
172,
185
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2626 | split_0_train_2626 | [
{
"id": "split_0_train_2626_passage",
"type": "progene_text",
"text": [
"Chemical inhibitors or dominant - negative forms of signaling components required to activate NF-kappa B , ATF , or AP-1 in response to IL-1 do not affect the phosphorylation of Stat1 on serine ."
],
"offsets": [
[
0,
195
]
]
}
]
| [
{
"id": "split_0_train_4102_entity",
"type": "progene_text",
"text": [
"NF-kappa B"
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"offsets": [
[
94,
104
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],
"normalized": []
},
{
"id": "split_0_train_4103_entity",
"type": "progene_text",
"text": [
"ATF"
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[
107,
110
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],
"normalized": []
},
{
"id": "split_0_train_4104_entity",
"type": "progene_text",
"text": [
"AP-1"
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"offsets": [
[
116,
120
]
],
"normalized": []
},
{
"id": "split_0_train_4105_entity",
"type": "progene_text",
"text": [
"IL-1"
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[
136,
140
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},
{
"id": "split_0_train_4106_entity",
"type": "progene_text",
"text": [
"Stat1"
],
"offsets": [
[
178,
183
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2627 | split_0_train_2627 | [
{
"id": "split_0_train_2627_passage",
"type": "progene_text",
"text": [
"IL-1 and tumor necrosis factor ( TNF ) enhance the serine phosphorylation of Stat1 that occurs in response to interferon-gamma ( IFN-gamma ) and potentiate IFN-gamma - mediated , Stat1 - driven gene expression , thus contributing to the synergistic activities of these proinflammatory cytokines ."
],
"offsets": [
[
0,
296
]
]
}
]
| [
{
"id": "split_0_train_4107_entity",
"type": "progene_text",
"text": [
"IL-1"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_4108_entity",
"type": "progene_text",
"text": [
"tumor necrosis factor"
],
"offsets": [
[
9,
30
]
],
"normalized": []
},
{
"id": "split_0_train_4109_entity",
"type": "progene_text",
"text": [
"TNF"
],
"offsets": [
[
33,
36
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],
"normalized": []
},
{
"id": "split_0_train_4110_entity",
"type": "progene_text",
"text": [
"Stat1"
],
"offsets": [
[
77,
82
]
],
"normalized": []
},
{
"id": "split_0_train_4111_entity",
"type": "progene_text",
"text": [
"interferon-gamma"
],
"offsets": [
[
110,
126
]
],
"normalized": []
},
{
"id": "split_0_train_4112_entity",
"type": "progene_text",
"text": [
"IFN-gamma"
],
"offsets": [
[
129,
138
]
],
"normalized": []
},
{
"id": "split_0_train_4113_entity",
"type": "progene_text",
"text": [
"IFN-gamma"
],
"offsets": [
[
156,
165
]
],
"normalized": []
},
{
"id": "split_0_train_4114_entity",
"type": "progene_text",
"text": [
"Stat1"
],
"offsets": [
[
179,
184
]
],
"normalized": []
},
{
"id": "split_0_train_4115_entity",
"type": "progene_text",
"text": [
"cytokines"
],
"offsets": [
[
285,
294
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2628 | split_0_train_2628 | [
{
"id": "split_0_train_2628_passage",
"type": "progene_text",
"text": [
"Cellular mechanisms of the hemostatic effects of desmopressin ( DDAVP ) ."
],
"offsets": [
[
0,
73
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2629 | split_0_train_2629 | [
{
"id": "split_0_train_2629_passage",
"type": "progene_text",
"text": [
"The synthetic analog of vasopressin desmopressin ( DDAVP ) is widely used for the treatment of patients with von Willebrand disease ( VWD ) , hemophilia A , several platelet disorders , and uremic bleeding ."
],
"offsets": [
[
0,
207
]
]
}
]
| [
{
"id": "split_0_train_4116_entity",
"type": "progene_text",
"text": [
"vasopressin"
],
"offsets": [
[
24,
35
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2630 | split_0_train_2630 | [
{
"id": "split_0_train_2630_passage",
"type": "progene_text",
"text": [
"DDAVP induces an increase in plasma levels of von Willebrand factor ( VWF ) , coagulation factor VIII ( FVIII ) , and tissue plasminogen activator ( t-PA ) ."
],
"offsets": [
[
0,
157
]
]
}
]
| [
{
"id": "split_0_train_4117_entity",
"type": "progene_text",
"text": [
"von Willebrand factor"
],
"offsets": [
[
46,
67
]
],
"normalized": []
},
{
"id": "split_0_train_4118_entity",
"type": "progene_text",
"text": [
"VWF"
],
"offsets": [
[
70,
73
]
],
"normalized": []
},
{
"id": "split_0_train_4119_entity",
"type": "progene_text",
"text": [
"coagulation factor VIII"
],
"offsets": [
[
78,
101
]
],
"normalized": []
},
{
"id": "split_0_train_4120_entity",
"type": "progene_text",
"text": [
"FVIII"
],
"offsets": [
[
104,
109
]
],
"normalized": []
},
{
"id": "split_0_train_4121_entity",
"type": "progene_text",
"text": [
"tissue plasminogen activator"
],
"offsets": [
[
118,
146
]
],
"normalized": []
},
{
"id": "split_0_train_4122_entity",
"type": "progene_text",
"text": [
"t-PA"
],
"offsets": [
[
149,
153
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2631 | split_0_train_2631 | [
{
"id": "split_0_train_2631_passage",
"type": "progene_text",
"text": [
"It also has a vasodilatory action ."
],
"offsets": [
[
0,
35
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2632 | split_0_train_2632 | [
{
"id": "split_0_train_2632_passage",
"type": "progene_text",
"text": [
"In spite of its extensive clinical use , its cellular mechanism of action remains incompletely understood ."
],
"offsets": [
[
0,
107
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2633 | split_0_train_2633 | [
{
"id": "split_0_train_2633_passage",
"type": "progene_text",
"text": [
"Its effect on VWF and t-PA as well as its vasodilatory effect are likely explained by a direct action on the endothelium , via activation of endothelial vasopressin V2R receptor and cAMP - mediated signaling ."
],
"offsets": [
[
0,
209
]
]
}
]
| [
{
"id": "split_0_train_4123_entity",
"type": "progene_text",
"text": [
"VWF"
],
"offsets": [
[
14,
17
]
],
"normalized": []
},
{
"id": "split_0_train_4124_entity",
"type": "progene_text",
"text": [
"t-PA"
],
"offsets": [
[
22,
26
]
],
"normalized": []
},
{
"id": "split_0_train_4125_entity",
"type": "progene_text",
"text": [
"vasopressin V2R receptor"
],
"offsets": [
[
153,
177
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2634 | split_0_train_2634 | [
{
"id": "split_0_train_2634_passage",
"type": "progene_text",
"text": [
"This leads to exocytosis from Weibel Palade bodies where both VWF and t-PA are stored , as well as to nitric oxide ( NO ) production via activation of endothelial NO synthase ."
],
"offsets": [
[
0,
176
]
]
}
]
| [
{
"id": "split_0_train_4126_entity",
"type": "progene_text",
"text": [
"VWF"
],
"offsets": [
[
62,
65
]
],
"normalized": []
},
{
"id": "split_0_train_4127_entity",
"type": "progene_text",
"text": [
"t-PA"
],
"offsets": [
[
70,
74
]
],
"normalized": []
},
{
"id": "split_0_train_4128_entity",
"type": "progene_text",
"text": [
"endothelial NO synthase"
],
"offsets": [
[
151,
174
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2635 | split_0_train_2635 | [
{
"id": "split_0_train_2635_passage",
"type": "progene_text",
"text": [
"The mechanism of action of DDAVP on FVIII plasma levels remains to be elucidated ."
],
"offsets": [
[
0,
82
]
]
}
]
| [
{
"id": "split_0_train_4129_entity",
"type": "progene_text",
"text": [
"FVIII"
],
"offsets": [
[
36,
41
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2636 | split_0_train_2636 | [
{
"id": "split_0_train_2636_passage",
"type": "progene_text",
"text": [
"The hemostatic effect of DDAVP likely involves additional cellular effects that remain to be discovered ."
],
"offsets": [
[
0,
105
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2637 | split_0_train_2637 | [
{
"id": "split_0_train_2637_passage",
"type": "progene_text",
"text": [
"Mapping the active sites of bacterial translation initiation factor IF3 ."
],
"offsets": [
[
0,
73
]
]
}
]
| [
{
"id": "split_0_train_4130_entity",
"type": "progene_text",
"text": [
"translation initiation factor"
],
"offsets": [
[
38,
67
]
],
"normalized": []
},
{
"id": "split_0_train_4131_entity",
"type": "progene_text",
"text": [
"IF3"
],
"offsets": [
[
68,
71
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2638 | split_0_train_2638 | [
{
"id": "split_0_train_2638_passage",
"type": "progene_text",
"text": [
"IF3C is the C - terminal domain of Escherichia coli translation initiation factor 3 ( IF3 ) and is responsible for all functions of this translation initiation factor but for its ribosomal recycling ."
],
"offsets": [
[
0,
200
]
]
}
]
| [
{
"id": "split_0_train_4132_entity",
"type": "progene_text",
"text": [
"IF3C"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_4133_entity",
"type": "progene_text",
"text": [
"translation initiation factor 3"
],
"offsets": [
[
52,
83
]
],
"normalized": []
},
{
"id": "split_0_train_4134_entity",
"type": "progene_text",
"text": [
"IF3"
],
"offsets": [
[
86,
89
]
],
"normalized": []
},
{
"id": "split_0_train_4135_entity",
"type": "progene_text",
"text": [
"translation initiation factor"
],
"offsets": [
[
137,
166
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2639 | split_0_train_2639 | [
{
"id": "split_0_train_2639_passage",
"type": "progene_text",
"text": [
"To map the number and nature of the active sites of IF3 and to identify the essential Arg residue(s) chemically modified with 2,3-butanedione , the eight arginine residues of IF3C were substituted by Lys , His , Ser and Leu , generating 32 variants that were tested in vitro for all known IF3 activities ."
],
"offsets": [
[
0,
305
]
]
}
]
| [
{
"id": "split_0_train_4136_entity",
"type": "progene_text",
"text": [
"IF3"
],
"offsets": [
[
52,
55
]
],
"normalized": []
},
{
"id": "split_0_train_4137_entity",
"type": "progene_text",
"text": [
"IF3C"
],
"offsets": [
[
175,
179
]
],
"normalized": []
},
{
"id": "split_0_train_4138_entity",
"type": "progene_text",
"text": [
"IF3"
],
"offsets": [
[
289,
292
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2640 | split_0_train_2640 | [
{
"id": "split_0_train_2640_passage",
"type": "progene_text",
"text": [
"The IF3 - 30S subunit interaction was inhibited strongly by substitutions of Arg99 , Arg112 , Arg116 , Arg147 and Arg168 , the positive charges being important at positions 116 and 147 ."
],
"offsets": [
[
0,
186
]
]
}
]
| [
{
"id": "split_0_train_4139_entity",
"type": "progene_text",
"text": [
"IF3"
],
"offsets": [
[
4,
7
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2641 | split_0_train_2641 | [
{
"id": "split_0_train_2641_passage",
"type": "progene_text",
"text": [
"The 70S ribosome dissociation was affected by mutations of Arg112 , Arg147 and , to a lesser extent , of Arg99 and Arg116 ."
],
"offsets": [
[
0,
123
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2642 | split_0_train_2642 | [
{
"id": "split_0_train_2642_passage",
"type": "progene_text",
"text": [
"Pseudo - initiation complex dissociation was impaired by substitution of Arg99 and Arg112 ( whose positive charges are important ) and , to a lesser extent , of Arg116 , Arg129 , Arg133 and Arg147 , while the dissociation of non - canonical 30S initiation complexes was preserved at wild - type levels in all 32 mutants ."
],
"offsets": [
[
0,
321
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2643 | split_0_train_2643 | [
{
"id": "split_0_train_2643_passage",
"type": "progene_text",
"text": [
"Stimulation of mRNA translation was reduced by mutations of Arg116 , Arg129 and , to a lesser extent , of Arg99 , Arg112 and Arg131 whereas inhibition of non - canonical mRNA translation was affected by substitutions of Arg99 , Arg112 , Arg168 and , to a lesser extent , Arg116 , Arg129 and Arg131 ."
],
"offsets": [
[
0,
299
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2644 | split_0_train_2644 | [
{
"id": "split_0_train_2644_passage",
"type": "progene_text",
"text": [
"Finally , repositioning the mRNA on the 30S subunit was affected weakly by mutations of Arg133 , Arg131 , Arg168 , Arg147 and Arg129 ."
],
"offsets": [
[
0,
134
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2645 | split_0_train_2645 | [
{
"id": "split_0_train_2645_passage",
"type": "progene_text",
"text": [
"Overall , the results define two active surfaces in IF3C , and indicate that the different functions of IF3 rely on different molecular mechanisms involving separate active sites ."
],
"offsets": [
[
0,
180
]
]
}
]
| [
{
"id": "split_0_train_4140_entity",
"type": "progene_text",
"text": [
"IF3C"
],
"offsets": [
[
52,
56
]
],
"normalized": []
},
{
"id": "split_0_train_4141_entity",
"type": "progene_text",
"text": [
"IF3"
],
"offsets": [
[
104,
107
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2646 | split_0_train_2646 | [
{
"id": "split_0_train_2646_passage",
"type": "progene_text",
"text": [
"[ Construction of the synthetic genes for protein analogs of spider silk carcass spidroin 1 and their expression in tobacco plants ]"
],
"offsets": [
[
0,
132
]
]
}
]
| [
{
"id": "split_0_train_4142_entity",
"type": "progene_text",
"text": [
"spidroin 1"
],
"offsets": [
[
81,
91
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2647 | split_0_train_2647 | [
{
"id": "split_0_train_2647_passage",
"type": "progene_text",
"text": [
"To obtain transgenic tobacco plants expressing recombinant analogs of spider dragline silk spidroin 1 , artificial 1f5 and 1f9 coding for spidroin 1 analogs were 3'-fused in - frame with the reporter lichenase gene ."
],
"offsets": [
[
0,
216
]
]
}
]
| [
{
"id": "split_0_train_4143_entity",
"type": "progene_text",
"text": [
"spidroin 1"
],
"offsets": [
[
91,
101
]
],
"normalized": []
},
{
"id": "split_0_train_4144_entity",
"type": "progene_text",
"text": [
"spidroin 1"
],
"offsets": [
[
138,
148
]
],
"normalized": []
},
{
"id": "split_0_train_4145_entity",
"type": "progene_text",
"text": [
"lichenase"
],
"offsets": [
[
200,
209
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2648 | split_0_train_2648 | [
{
"id": "split_0_train_2648_passage",
"type": "progene_text",
"text": [
"The Tr2' weak constitutive promoter of Agrobacterium tumefaciens T-DNA and the strong constitutive promoter of the cauliflower mosaic virus 35S RNA gene were used as regulatory elements ."
],
"offsets": [
[
0,
187
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2649 | split_0_train_2649 | [
{
"id": "split_0_train_2649_passage",
"type": "progene_text",
"text": [
"The expression cassettes were used to transform agrobacteria and then introduced in tobacco leaf disks ."
],
"offsets": [
[
0,
104
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2650 | split_0_train_2650 | [
{
"id": "split_0_train_2650_passage",
"type": "progene_text",
"text": [
"On evidence of Southern hybridization , transgenic plants each carried a single copy of a hybrid gene , which corresponded in size to the constructed one ."
],
"offsets": [
[
0,
155
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2651 | split_0_train_2651 | [
{
"id": "split_0_train_2651_passage",
"type": "progene_text",
"text": [
"Zymography and Western blotting revealed full - length hybrid proteins in leaf extracts of transgenic plants ."
],
"offsets": [
[
0,
110
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2652 | split_0_train_2652 | [
{
"id": "split_0_train_2652_passage",
"type": "progene_text",
"text": [
"The results testified that plants can maintain and express synthetic genes for spider silks and , consequently , may be used as a convenient producer of recombinant silk analogs ."
],
"offsets": [
[
0,
179
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2653 | split_0_train_2653 | [
{
"id": "split_0_train_2653_passage",
"type": "progene_text",
"text": [
"The respiratory arsenate reductase from Bacillus selenitireducens strain MLS10 ."
],
"offsets": [
[
0,
80
]
]
}
]
| [
{
"id": "split_0_train_4146_entity",
"type": "progene_text",
"text": [
"arsenate reductase"
],
"offsets": [
[
16,
34
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2654 | split_0_train_2654 | [
{
"id": "split_0_train_2654_passage",
"type": "progene_text",
"text": [
"The respiratory arsenate reductase from the Gram - positive , haloalkaliphile , Bacillus selenitireducens strain MLS10 was purified and characterized ."
],
"offsets": [
[
0,
151
]
]
}
]
| [
{
"id": "split_0_train_4147_entity",
"type": "progene_text",
"text": [
"arsenate reductase"
],
"offsets": [
[
16,
34
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2655 | split_0_train_2655 | [
{
"id": "split_0_train_2655_passage",
"type": "progene_text",
"text": [
"It is a membrane bound heterodimer ( 150 kDa ) composed of two subunits ArrA ( 110 kDa ) and ArrB ( 34 kDa ) , with an apparent K(m) for arsenate of 34 microM and V(max) of 2.5 micromol min(-1) mg(-1) ."
],
"offsets": [
[
0,
202
]
]
}
]
| [
{
"id": "split_0_train_4148_entity",
"type": "progene_text",
"text": [
"ArrA"
],
"offsets": [
[
72,
76
]
],
"normalized": []
},
{
"id": "split_0_train_4149_entity",
"type": "progene_text",
"text": [
"ArrB"
],
"offsets": [
[
93,
97
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2656 | split_0_train_2656 | [
{
"id": "split_0_train_2656_passage",
"type": "progene_text",
"text": [
"Optimal activity occurred at pH 9.5 and 150 g l(-1) of NaCl ."
],
"offsets": [
[
0,
61
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2657 | split_0_train_2657 | [
{
"id": "split_0_train_2657_passage",
"type": "progene_text",
"text": [
"Metal analysis ( inductively coupled plasma mass spectrometry ) of the holoenzyme and sequence analysis of the catalytic subunit ( ArrA ; the gene for which was cloned and sequenced ) indicate it is a member of the DMSO reductase family of molybdoproteins ."
],
"offsets": [
[
0,
257
]
]
}
]
| [
{
"id": "split_0_train_4150_entity",
"type": "progene_text",
"text": [
"ArrA"
],
"offsets": [
[
131,
135
]
],
"normalized": []
},
{
"id": "split_0_train_4151_entity",
"type": "progene_text",
"text": [
"DMSO reductase family"
],
"offsets": [
[
215,
236
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2658 | split_0_train_2658 | [
{
"id": "split_0_train_2658_passage",
"type": "progene_text",
"text": [
"Organization of the mouse Zfhx1b gene encoding the two - handed zinc finger repressor Smad - interacting protein-1 ."
],
"offsets": [
[
0,
116
]
]
}
]
| [
{
"id": "split_0_train_4152_entity",
"type": "progene_text",
"text": [
"Zfhx1b"
],
"offsets": [
[
26,
32
]
],
"normalized": []
},
{
"id": "split_0_train_4153_entity",
"type": "progene_text",
"text": [
"Smad - interacting protein-1"
],
"offsets": [
[
86,
114
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2659 | split_0_train_2659 | [
{
"id": "split_0_train_2659_passage",
"type": "progene_text",
"text": [
"SIP1 , a member of the deltaEF1 family of two - handed zinc finger transcriptional repressors , has been identified as a Smad - binding protein ."
],
"offsets": [
[
0,
145
]
]
}
]
| [
{
"id": "split_0_train_4154_entity",
"type": "progene_text",
"text": [
"SIP1"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_4155_entity",
"type": "progene_text",
"text": [
"deltaEF1 family"
],
"offsets": [
[
23,
38
]
],
"normalized": []
},
{
"id": "split_0_train_4156_entity",
"type": "progene_text",
"text": [
"Smad"
],
"offsets": [
[
121,
125
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2660 | split_0_train_2660 | [
{
"id": "split_0_train_2660_passage",
"type": "progene_text",
"text": [
"Recently , mutations in the human SIP1 gene ( ZFHX1B ) have been implicated in Hirschsprung disease ."
],
"offsets": [
[
0,
101
]
]
}
]
| [
{
"id": "split_0_train_4157_entity",
"type": "progene_text",
"text": [
"SIP1"
],
"offsets": [
[
34,
38
]
],
"normalized": []
},
{
"id": "split_0_train_4158_entity",
"type": "progene_text",
"text": [
"ZFHX1B"
],
"offsets": [
[
46,
52
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2661 | split_0_train_2661 | [
{
"id": "split_0_train_2661_passage",
"type": "progene_text",
"text": [
"Here we document extensively the structure and transcriptional pattern of the mouse SIP1 gene ( Zfhx1b ) and compare it to homologues from other species ."
],
"offsets": [
[
0,
154
]
]
}
]
| [
{
"id": "split_0_train_4159_entity",
"type": "progene_text",
"text": [
"SIP1"
],
"offsets": [
[
84,
88
]
],
"normalized": []
},
{
"id": "split_0_train_4160_entity",
"type": "progene_text",
"text": [
"Zfhx1b"
],
"offsets": [
[
96,
102
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2662 | split_0_train_2662 | [
{
"id": "split_0_train_2662_passage",
"type": "progene_text",
"text": [
"The overall structure of Zfhx1b is highly similar to that of the deltaEF1 gene ( Zfhx1a ) , confirming their close evolutionary relationship ."
],
"offsets": [
[
0,
142
]
]
}
]
| [
{
"id": "split_0_train_4161_entity",
"type": "progene_text",
"text": [
"Zfhx1b"
],
"offsets": [
[
25,
31
]
],
"normalized": []
},
{
"id": "split_0_train_4162_entity",
"type": "progene_text",
"text": [
"deltaEF1"
],
"offsets": [
[
65,
73
]
],
"normalized": []
},
{
"id": "split_0_train_4163_entity",
"type": "progene_text",
"text": [
"Zfhx1a"
],
"offsets": [
[
81,
87
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2663 | split_0_train_2663 | [
{
"id": "split_0_train_2663_passage",
"type": "progene_text",
"text": [
"In contrast to Zfhx1a , the 5 ' untranslated region of the SIP1 - encoding mouse gene is very complex and includes several alternative exons ."
],
"offsets": [
[
0,
142
]
]
}
]
| [
{
"id": "split_0_train_4164_entity",
"type": "progene_text",
"text": [
"Zfhx1a"
],
"offsets": [
[
15,
21
]
],
"normalized": []
},
{
"id": "split_0_train_4165_entity",
"type": "progene_text",
"text": [
"SIP1"
],
"offsets": [
[
59,
63
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2664 | split_0_train_2664 | [
{
"id": "split_0_train_2664_passage",
"type": "progene_text",
"text": [
"The corresponding 5'-UTR splicing pattern seems to be conserved between species and suggests a role in its transcriptional and/or translational regulation ."
],
"offsets": [
[
0,
156
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2665 | split_0_train_2665 | [
{
"id": "split_0_train_2665_passage",
"type": "progene_text",
"text": [
"The gene also codes for an antisense transcript that is highly conserved between human and mouse ."
],
"offsets": [
[
0,
98
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2666 | split_0_train_2666 | [
{
"id": "split_0_train_2666_passage",
"type": "progene_text",
"text": [
"Interaction with Tap42 is required for the essential function of Sit4 and type 2A phosphatases ."
],
"offsets": [
[
0,
96
]
]
}
]
| [
{
"id": "split_0_train_4166_entity",
"type": "progene_text",
"text": [
"Tap42"
],
"offsets": [
[
17,
22
]
],
"normalized": []
},
{
"id": "split_0_train_4167_entity",
"type": "progene_text",
"text": [
"Sit4"
],
"offsets": [
[
65,
69
]
],
"normalized": []
},
{
"id": "split_0_train_4168_entity",
"type": "progene_text",
"text": [
"type 2A phosphatases"
],
"offsets": [
[
74,
94
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2667 | split_0_train_2667 | [
{
"id": "split_0_train_2667_passage",
"type": "progene_text",
"text": [
"In Saccharomyces cerevisiae , Pph21 and Pph22 are the two catalytic subunits of type 2A phosphatase ( PP2Ac ) , and Sit4 is a major form of 2A - like phosphatase ."
],
"offsets": [
[
0,
163
]
]
}
]
| [
{
"id": "split_0_train_4169_entity",
"type": "progene_text",
"text": [
"Pph21"
],
"offsets": [
[
30,
35
]
],
"normalized": []
},
{
"id": "split_0_train_4170_entity",
"type": "progene_text",
"text": [
"Pph22"
],
"offsets": [
[
40,
45
]
],
"normalized": []
},
{
"id": "split_0_train_4171_entity",
"type": "progene_text",
"text": [
"catalytic subunits of type 2A phosphatase"
],
"offsets": [
[
58,
99
]
],
"normalized": []
},
{
"id": "split_0_train_4172_entity",
"type": "progene_text",
"text": [
"PP2Ac"
],
"offsets": [
[
102,
107
]
],
"normalized": []
},
{
"id": "split_0_train_4173_entity",
"type": "progene_text",
"text": [
"Sit4"
],
"offsets": [
[
116,
120
]
],
"normalized": []
},
{
"id": "split_0_train_4174_entity",
"type": "progene_text",
"text": [
"phosphatase"
],
"offsets": [
[
150,
161
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2668 | split_0_train_2668 | [
{
"id": "split_0_train_2668_passage",
"type": "progene_text",
"text": [
"The function of these phosphatases requires their association with different regulatory subunits ."
],
"offsets": [
[
0,
98
]
]
}
]
| [
{
"id": "split_0_train_4175_entity",
"type": "progene_text",
"text": [
"phosphatases"
],
"offsets": [
[
22,
34
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2669 | split_0_train_2669 | [
{
"id": "split_0_train_2669_passage",
"type": "progene_text",
"text": [
"In addition to the conventional regulatory subunits , namely , the A and B subunits for Pph21 / 22 and the Sap proteins for Sit4 , these phosphatases have been found to associate with a protein termed Tap42 ."
],
"offsets": [
[
0,
208
]
]
}
]
| [
{
"id": "split_0_train_4176_entity",
"type": "progene_text",
"text": [
"Pph21 / 22"
],
"offsets": [
[
88,
98
]
],
"normalized": []
},
{
"id": "split_0_train_4177_entity",
"type": "progene_text",
"text": [
"Sap"
],
"offsets": [
[
107,
110
]
],
"normalized": []
},
{
"id": "split_0_train_4178_entity",
"type": "progene_text",
"text": [
"Sit4"
],
"offsets": [
[
124,
128
]
],
"normalized": []
},
{
"id": "split_0_train_4179_entity",
"type": "progene_text",
"text": [
"phosphatases"
],
"offsets": [
[
137,
149
]
],
"normalized": []
},
{
"id": "split_0_train_4180_entity",
"type": "progene_text",
"text": [
"Tap42"
],
"offsets": [
[
201,
206
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2670 | split_0_train_2670 | [
{
"id": "split_0_train_2670_passage",
"type": "progene_text",
"text": [
"In this study , we demonstrated that Sit4 and PP2Ac interact with Tap42 via an N - terminal domain that is conserved in all type 2A and 2A - like phosphatases ."
],
"offsets": [
[
0,
160
]
]
}
]
| [
{
"id": "split_0_train_4181_entity",
"type": "progene_text",
"text": [
"Sit4"
],
"offsets": [
[
37,
41
]
],
"normalized": []
},
{
"id": "split_0_train_4182_entity",
"type": "progene_text",
"text": [
"PP2Ac"
],
"offsets": [
[
46,
51
]
],
"normalized": []
},
{
"id": "split_0_train_4183_entity",
"type": "progene_text",
"text": [
"Tap42"
],
"offsets": [
[
66,
71
]
],
"normalized": []
},
{
"id": "split_0_train_4184_entity",
"type": "progene_text",
"text": [
"phosphatases"
],
"offsets": [
[
146,
158
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2671 | split_0_train_2671 | [
{
"id": "split_0_train_2671_passage",
"type": "progene_text",
"text": [
"We found that the Sit4 phosphatase in the sit4 - 102 strain contains a reverse - of - charge amino acid substitution within its Tap42 binding domain and is defective for formation of the Tap42 - Sit4 complex ."
],
"offsets": [
[
0,
209
]
]
}
]
| [
{
"id": "split_0_train_4185_entity",
"type": "progene_text",
"text": [
"Sit4"
],
"offsets": [
[
18,
22
]
],
"normalized": []
},
{
"id": "split_0_train_4186_entity",
"type": "progene_text",
"text": [
"phosphatase"
],
"offsets": [
[
23,
34
]
],
"normalized": []
},
{
"id": "split_0_train_4187_entity",
"type": "progene_text",
"text": [
"sit4"
],
"offsets": [
[
42,
46
]
],
"normalized": []
},
{
"id": "split_0_train_4188_entity",
"type": "progene_text",
"text": [
"Tap42"
],
"offsets": [
[
128,
133
]
],
"normalized": []
},
{
"id": "split_0_train_4189_entity",
"type": "progene_text",
"text": [
"Tap42"
],
"offsets": [
[
187,
192
]
],
"normalized": []
},
{
"id": "split_0_train_4190_entity",
"type": "progene_text",
"text": [
"Sit4"
],
"offsets": [
[
195,
199
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2672 | split_0_train_2672 | [
{
"id": "split_0_train_2672_passage",
"type": "progene_text",
"text": [
"Our results suggest that the interaction with Tap42 is required for the activity as well as for the essential function of Sit4 and PP2Ac ."
],
"offsets": [
[
0,
138
]
]
}
]
| [
{
"id": "split_0_train_4191_entity",
"type": "progene_text",
"text": [
"Tap42"
],
"offsets": [
[
46,
51
]
],
"normalized": []
},
{
"id": "split_0_train_4192_entity",
"type": "progene_text",
"text": [
"Sit4"
],
"offsets": [
[
122,
126
]
],
"normalized": []
},
{
"id": "split_0_train_4193_entity",
"type": "progene_text",
"text": [
"PP2Ac"
],
"offsets": [
[
131,
136
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2673 | split_0_train_2673 | [
{
"id": "split_0_train_2673_passage",
"type": "progene_text",
"text": [
"In addition , we showed that Tap42 is able to interact with two other 2A - like phosphatases , Pph3 and Ppg1 ."
],
"offsets": [
[
0,
110
]
]
}
]
| [
{
"id": "split_0_train_4194_entity",
"type": "progene_text",
"text": [
"Tap42"
],
"offsets": [
[
29,
34
]
],
"normalized": []
},
{
"id": "split_0_train_4195_entity",
"type": "progene_text",
"text": [
"phosphatases"
],
"offsets": [
[
80,
92
]
],
"normalized": []
},
{
"id": "split_0_train_4196_entity",
"type": "progene_text",
"text": [
"Pph3"
],
"offsets": [
[
95,
99
]
],
"normalized": []
},
{
"id": "split_0_train_4197_entity",
"type": "progene_text",
"text": [
"Ppg1"
],
"offsets": [
[
104,
108
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2674 | split_0_train_2674 | [
{
"id": "split_0_train_2674_passage",
"type": "progene_text",
"text": [
"Evidence that the 37 kDa protein of Soil - borne wheat mosaic virus is a virus movement protein ."
],
"offsets": [
[
0,
97
]
]
}
]
| [
{
"id": "split_0_train_4198_entity",
"type": "progene_text",
"text": [
"37 kDa protein"
],
"offsets": [
[
18,
32
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2675 | split_0_train_2675 | [
{
"id": "split_0_train_2675_passage",
"type": "progene_text",
"text": [
"Experiments were conducted to determine if the 37 kDa protein ( 37K ) of Soil - borne wheat mosaic virus ( SBWMV ) is a virus movement protein ."
],
"offsets": [
[
0,
144
]
]
}
]
| [
{
"id": "split_0_train_4199_entity",
"type": "progene_text",
"text": [
"37 kDa protein"
],
"offsets": [
[
47,
61
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2676 | split_0_train_2676 | [
{
"id": "split_0_train_2676_passage",
"type": "progene_text",
"text": [
"First , evidence was obtained that indicated that 37K has the ability to move from cell to cell , similar to other virus movement proteins ( MPs ) ."
],
"offsets": [
[
0,
148
]
]
}
]
| [
{
"id": "split_0_train_4200_entity",
"type": "progene_text",
"text": [
"37K"
],
"offsets": [
[
50,
53
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2677 | split_0_train_2677 | [
{
"id": "split_0_train_2677_passage",
"type": "progene_text",
"text": [
"Plasmids containing the GFP gene fused to the SBWMV 37K , the coat protein ( CP ) or the CP readthrough domain ( RT ) ORFs were delivered by biolistic bombardment to wheat and tobacco leaves ."
],
"offsets": [
[
0,
192
]
]
}
]
| [
{
"id": "split_0_train_4201_entity",
"type": "progene_text",
"text": [
"GFP"
],
"offsets": [
[
24,
27
]
],
"normalized": []
},
{
"id": "split_0_train_4202_entity",
"type": "progene_text",
"text": [
"37K"
],
"offsets": [
[
52,
55
]
],
"normalized": []
},
{
"id": "split_0_train_4203_entity",
"type": "progene_text",
"text": [
"coat protein"
],
"offsets": [
[
62,
74
]
],
"normalized": []
},
{
"id": "split_0_train_4204_entity",
"type": "progene_text",
"text": [
"CP"
],
"offsets": [
[
77,
79
]
],
"normalized": []
},
{
"id": "split_0_train_4205_entity",
"type": "progene_text",
"text": [
"CP"
],
"offsets": [
[
89,
91
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2678 | split_0_train_2678 | [
{
"id": "split_0_train_2678_passage",
"type": "progene_text",
"text": [
"In wheat leaves , cell - to - cell movement of GFP - 37K was observed , while GFP , GFP - CP and GFP - RT accumulated primarily in single cells ."
],
"offsets": [
[
0,
145
]
]
}
]
| [
{
"id": "split_0_train_4206_entity",
"type": "progene_text",
"text": [
"GFP"
],
"offsets": [
[
47,
50
]
],
"normalized": []
},
{
"id": "split_0_train_4207_entity",
"type": "progene_text",
"text": [
"37K"
],
"offsets": [
[
53,
56
]
],
"normalized": []
},
{
"id": "split_0_train_4208_entity",
"type": "progene_text",
"text": [
"GFP"
],
"offsets": [
[
78,
81
]
],
"normalized": []
},
{
"id": "split_0_train_4209_entity",
"type": "progene_text",
"text": [
"GFP"
],
"offsets": [
[
84,
87
]
],
"normalized": []
},
{
"id": "split_0_train_4210_entity",
"type": "progene_text",
"text": [
"CP"
],
"offsets": [
[
90,
92
]
],
"normalized": []
},
{
"id": "split_0_train_4211_entity",
"type": "progene_text",
"text": [
"GFP"
],
"offsets": [
[
97,
100
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2679 | split_0_train_2679 | [
{
"id": "split_0_train_2679_passage",
"type": "progene_text",
"text": [
"All fusion proteins accumulated in single cells in tobacco leaves ."
],
"offsets": [
[
0,
67
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2680 | split_0_train_2680 | [
{
"id": "split_0_train_2680_passage",
"type": "progene_text",
"text": [
"Thus , cell - to - cell movement is a specific property of 37K that occurs in SBWMV host plants ."
],
"offsets": [
[
0,
97
]
]
}
]
| [
{
"id": "split_0_train_4212_entity",
"type": "progene_text",
"text": [
"37K"
],
"offsets": [
[
59,
62
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2681 | split_0_train_2681 | [
{
"id": "split_0_train_2681_passage",
"type": "progene_text",
"text": [
"Subcellular accumulation of 37K was studied using SBWMV - infected and 37K - expressing transgenic wheat ."
],
"offsets": [
[
0,
106
]
]
}
]
| [
{
"id": "split_0_train_4213_entity",
"type": "progene_text",
"text": [
"37K"
],
"offsets": [
[
28,
31
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2682 | split_0_train_2682 | [
{
"id": "split_0_train_2682_passage",
"type": "progene_text",
"text": [
"In infected and transgenic wheat leaves , 37K accumulated in the cell wall , similar to other virus MPs , and in aggregates in the cytoplasm ."
],
"offsets": [
[
0,
142
]
]
}
]
| [
{
"id": "split_0_train_4214_entity",
"type": "progene_text",
"text": [
"37K"
],
"offsets": [
[
42,
45
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2683 | split_0_train_2683 | [
{
"id": "split_0_train_2683_passage",
"type": "progene_text",
"text": [
"Phylogenetic studies were conducted to compare the furovirus 37K proteins with members of the 30K superfamily of virus MPs ."
],
"offsets": [
[
0,
124
]
]
}
]
| [
{
"id": "split_0_train_4215_entity",
"type": "progene_text",
"text": [
"37K proteins"
],
"offsets": [
[
61,
73
]
],
"normalized": []
},
{
"id": "split_0_train_4216_entity",
"type": "progene_text",
"text": [
"30K superfamily"
],
"offsets": [
[
94,
109
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2684 | split_0_train_2684 | [
{
"id": "split_0_train_2684_passage",
"type": "progene_text",
"text": [
"Amino acid sequences of the furovirus 37K proteins were aligned with the MPs from 43 representative viruses ."
],
"offsets": [
[
0,
109
]
]
}
]
| [
{
"id": "split_0_train_4217_entity",
"type": "progene_text",
"text": [
"37K proteins"
],
"offsets": [
[
38,
50
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2685 | split_0_train_2685 | [
{
"id": "split_0_train_2685_passage",
"type": "progene_text",
"text": [
"The furovirus 37K proteins were found to reside in a clade that also contained the dianthovirus MPs ."
],
"offsets": [
[
0,
101
]
]
}
]
| [
{
"id": "split_0_train_4218_entity",
"type": "progene_text",
"text": [
"37K proteins"
],
"offsets": [
[
14,
26
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2686 | split_0_train_2686 | [
{
"id": "split_0_train_2686_passage",
"type": "progene_text",
"text": [
"Combined , these data suggest that SBWMV 37K is probably a virus MP ."
],
"offsets": [
[
0,
69
]
]
}
]
| [
{
"id": "split_0_train_4219_entity",
"type": "progene_text",
"text": [
"37K"
],
"offsets": [
[
41,
44
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2687 | split_0_train_2687 | [
{
"id": "split_0_train_2687_passage",
"type": "progene_text",
"text": [
"Accumulation of the amyloid precursor - like protein APLP2 and reduction of APLP1 in retinoic acid - differentiated human neuroblastoma cells upon curcumin - induced neurite retraction ."
],
"offsets": [
[
0,
186
]
]
}
]
| [
{
"id": "split_0_train_4220_entity",
"type": "progene_text",
"text": [
"amyloid precursor - like protein"
],
"offsets": [
[
20,
52
]
],
"normalized": []
},
{
"id": "split_0_train_4221_entity",
"type": "progene_text",
"text": [
"APLP2"
],
"offsets": [
[
53,
58
]
],
"normalized": []
},
{
"id": "split_0_train_4222_entity",
"type": "progene_text",
"text": [
"APLP1"
],
"offsets": [
[
76,
81
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2688 | split_0_train_2688 | [
{
"id": "split_0_train_2688_passage",
"type": "progene_text",
"text": [
"Amyloid precursor protein ( APP ) belongs to a conserved gene family , also including the amyloid precursor - like proteins , APLP1 and APLP2 ."
],
"offsets": [
[
0,
143
]
]
}
]
| [
{
"id": "split_0_train_4223_entity",
"type": "progene_text",
"text": [
"Amyloid precursor protein"
],
"offsets": [
[
0,
25
]
],
"normalized": []
},
{
"id": "split_0_train_4224_entity",
"type": "progene_text",
"text": [
"APP"
],
"offsets": [
[
28,
31
]
],
"normalized": []
},
{
"id": "split_0_train_4225_entity",
"type": "progene_text",
"text": [
"amyloid precursor - like proteins"
],
"offsets": [
[
90,
123
]
],
"normalized": []
},
{
"id": "split_0_train_4226_entity",
"type": "progene_text",
"text": [
"APLP1"
],
"offsets": [
[
126,
131
]
],
"normalized": []
},
{
"id": "split_0_train_4227_entity",
"type": "progene_text",
"text": [
"APLP2"
],
"offsets": [
[
136,
141
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2689 | split_0_train_2689 | [
{
"id": "split_0_train_2689_passage",
"type": "progene_text",
"text": [
"The function of these three proteins is not yet fully understood ."
],
"offsets": [
[
0,
66
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2690 | split_0_train_2690 | [
{
"id": "split_0_train_2690_passage",
"type": "progene_text",
"text": [
"One of the proposed roles of APP is to promote neurite outgrowth ."
],
"offsets": [
[
0,
66
]
]
}
]
| [
{
"id": "split_0_train_4228_entity",
"type": "progene_text",
"text": [
"APP"
],
"offsets": [
[
29,
32
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2691 | split_0_train_2691 | [
{
"id": "split_0_train_2691_passage",
"type": "progene_text",
"text": [
"The aim of this study was to investigate the regulation of the expression levels of APP family members during neurite outgrowth ."
],
"offsets": [
[
0,
129
]
]
}
]
| [
{
"id": "split_0_train_4229_entity",
"type": "progene_text",
"text": [
"APP family"
],
"offsets": [
[
84,
94
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2692 | split_0_train_2692 | [
{
"id": "split_0_train_2692_passage",
"type": "progene_text",
"text": [
"We observed that retinoic acid ( RA ) - induced neuronal differentiation of human SH-SY5Y cells resulted in increased expression of APP , APLP1 and APLP2 ."
],
"offsets": [
[
0,
155
]
]
}
]
| [
{
"id": "split_0_train_4230_entity",
"type": "progene_text",
"text": [
"APP"
],
"offsets": [
[
132,
135
]
],
"normalized": []
},
{
"id": "split_0_train_4231_entity",
"type": "progene_text",
"text": [
"APLP1"
],
"offsets": [
[
138,
143
]
],
"normalized": []
},
{
"id": "split_0_train_4232_entity",
"type": "progene_text",
"text": [
"APLP2"
],
"offsets": [
[
148,
153
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2693 | split_0_train_2693 | [
{
"id": "split_0_train_2693_passage",
"type": "progene_text",
"text": [
"We also examined the effect of the NFkappaB , AP-1 and c-Jun N - terminal kinase inhibitor curcumin ( diferuloylmethane ) on the RA - induced expression levels of these proteins ."
],
"offsets": [
[
0,
179
]
]
}
]
| [
{
"id": "split_0_train_4233_entity",
"type": "progene_text",
"text": [
"NFkappaB"
],
"offsets": [
[
35,
43
]
],
"normalized": []
},
{
"id": "split_0_train_4234_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
46,
50
]
],
"normalized": []
},
{
"id": "split_0_train_4235_entity",
"type": "progene_text",
"text": [
"c-Jun N - terminal kinase"
],
"offsets": [
[
55,
80
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2694 | split_0_train_2694 | [
{
"id": "split_0_train_2694_passage",
"type": "progene_text",
"text": [
"We found that treatment with curcumin counteracted the RA - induced mRNA expression of all APP family members ."
],
"offsets": [
[
0,
111
]
]
}
]
| [
{
"id": "split_0_train_4236_entity",
"type": "progene_text",
"text": [
"APP family"
],
"offsets": [
[
91,
101
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2695 | split_0_train_2695 | [
{
"id": "split_0_train_2695_passage",
"type": "progene_text",
"text": [
"In addition , we observed that curcumin treatment resulted in neurite retraction without any effect on cell viability ."
],
"offsets": [
[
0,
119
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2696 | split_0_train_2696 | [
{
"id": "split_0_train_2696_passage",
"type": "progene_text",
"text": [
"Surprisingly , curcumin had differential effects on the APLP protein levels in RA - differentiated cells ."
],
"offsets": [
[
0,
106
]
]
}
]
| [
{
"id": "split_0_train_4237_entity",
"type": "progene_text",
"text": [
"APLP"
],
"offsets": [
[
56,
60
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2697 | split_0_train_2697 | [
{
"id": "split_0_train_2697_passage",
"type": "progene_text",
"text": [
"RA - induced APLP1 protein expression was blocked by curcumin , while the APLP2 protein levels were further increased ."
],
"offsets": [
[
0,
119
]
]
}
]
| [
{
"id": "split_0_train_4238_entity",
"type": "progene_text",
"text": [
"APLP1"
],
"offsets": [
[
13,
18
]
],
"normalized": []
},
{
"id": "split_0_train_4239_entity",
"type": "progene_text",
"text": [
"APLP2"
],
"offsets": [
[
74,
79
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2698 | split_0_train_2698 | [
{
"id": "split_0_train_2698_passage",
"type": "progene_text",
"text": [
"APP protein levels were not affected by curcumin treatment ."
],
"offsets": [
[
0,
60
]
]
}
]
| [
{
"id": "split_0_train_4240_entity",
"type": "progene_text",
"text": [
"APP"
],
"offsets": [
[
0,
3
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2699 | split_0_train_2699 | [
{
"id": "split_0_train_2699_passage",
"type": "progene_text",
"text": [
"We propose that the sustained levels of APP and the elevated levels of APLP2 , in spite of the reduced mRNA expression , are due to altered proteolytic processing of these proteins ."
],
"offsets": [
[
0,
182
]
]
}
]
| [
{
"id": "split_0_train_4241_entity",
"type": "progene_text",
"text": [
"APP"
],
"offsets": [
[
40,
43
]
],
"normalized": []
},
{
"id": "split_0_train_4242_entity",
"type": "progene_text",
"text": [
"APLP2"
],
"offsets": [
[
71,
76
]
],
"normalized": []
}
]
| []
| []
| []
|
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