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stringlengths 15
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split_0_train_2100 | split_0_train_2100 | [
{
"id": "split_0_train_2100_passage",
"type": "progene_text",
"text": [
"PMA induced membrane localization of RasGRP4 and 32D cells expressing RasGRP4 were capable of cytokine - independent proliferation in the presence of PMA ."
],
"offsets": [
[
0,
155
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]
}
]
| [
{
"id": "split_0_train_3178_entity",
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"RasGRP4"
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[
37,
44
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{
"id": "split_0_train_3179_entity",
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"RasGRP4"
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70,
77
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},
{
"id": "split_0_train_3180_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
94,
102
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2101 | split_0_train_2101 | [
{
"id": "split_0_train_2101_passage",
"type": "progene_text",
"text": [
"We conclude that RasGRP4 is a member of the RasGRP family of Ras guanine nucleotide exchange factors that may play a role in myeloid cell signaling growth regulation pathways that are responsive to diacylglycerol levels ."
],
"offsets": [
[
0,
221
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]
}
]
| [
{
"id": "split_0_train_3181_entity",
"type": "progene_text",
"text": [
"RasGRP4"
],
"offsets": [
[
17,
24
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],
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{
"id": "split_0_train_3182_entity",
"type": "progene_text",
"text": [
"RasGRP family"
],
"offsets": [
[
44,
57
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],
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},
{
"id": "split_0_train_3183_entity",
"type": "progene_text",
"text": [
"Ras guanine nucleotide exchange factors"
],
"offsets": [
[
61,
100
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2102 | split_0_train_2102 | [
{
"id": "split_0_train_2102_passage",
"type": "progene_text",
"text": [
"Linking objects in the process of mourning for sons disappeared in war : Croatia 2001 ."
],
"offsets": [
[
0,
87
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2103 | split_0_train_2103 | [
{
"id": "split_0_train_2103_passage",
"type": "progene_text",
"text": [
"AIM :"
],
"offsets": [
[
0,
5
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2104 | split_0_train_2104 | [
{
"id": "split_0_train_2104_passage",
"type": "progene_text",
"text": [
"Mothers use linking object to externalize the complex aspects of their relationship to the loss of their child ."
],
"offsets": [
[
0,
112
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2105 | split_0_train_2105 | [
{
"id": "split_0_train_2105_passage",
"type": "progene_text",
"text": [
"We analyzed the linking objects that mothers kept in memory of their sons who disappeared in the 1991 - 1995 war in Croatia or whose remains were uncovered and identified long time after they had gone missing ."
],
"offsets": [
[
0,
210
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2106 | split_0_train_2106 | [
{
"id": "split_0_train_2106_passage",
"type": "progene_text",
"text": [
"METHOD :"
],
"offsets": [
[
0,
8
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2107 | split_0_train_2107 | [
{
"id": "split_0_train_2107_passage",
"type": "progene_text",
"text": [
"The case study of disturbed mourning included 26 mothers of Croatian soldiers from Croatian Osijek - Baranja County who went missing in war or whose remains were recovered and identified long after they had gone missing ."
],
"offsets": [
[
0,
221
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2108 | split_0_train_2108 | [
{
"id": "split_0_train_2108_passage",
"type": "progene_text",
"text": [
"The mothers were selected independently by the president of the Association of Families of Missing and Detained Croatian Soldiers and agreed to participate in the study in 2001 ."
],
"offsets": [
[
0,
178
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2109 | split_0_train_2109 | [
{
"id": "split_0_train_2109_passage",
"type": "progene_text",
"text": [
"They were interviewed in their homes , their testimonies were recorded , and photographs of the linking objects taken ."
],
"offsets": [
[
0,
119
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2110 | split_0_train_2110 | [
{
"id": "split_0_train_2110_passage",
"type": "progene_text",
"text": [
"Linking objects were classified according to the Volkan 's four - group classification ."
],
"offsets": [
[
0,
88
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2111 | split_0_train_2111 | [
{
"id": "split_0_train_2111_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2112 | split_0_train_2112 | [
{
"id": "split_0_train_2112_passage",
"type": "progene_text",
"text": [
"Out of four Volkan 's groups of linking objects , we identified the objects belonging to the first three ."
],
"offsets": [
[
0,
106
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2113 | split_0_train_2113 | [
{
"id": "split_0_train_2113_passage",
"type": "progene_text",
"text": [
"Those were 1 ) objects that had been worn by the deceased ( clothes , wrist - watch , ring , or glasses ) , ( 6 / 26 ) ; 2 ) objects that could be viewed in the psychoanalytic sense as an extension of the body of the disappeared or dead person , such as a camera ( 4 / 26 ) ; and 3) objects with realistic or symbolic resemblance to the deceased , usually a photograph ( 8 / 26 ) ."
],
"offsets": [
[
0,
381
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2114 | split_0_train_2114 | [
{
"id": "split_0_train_2114_passage",
"type": "progene_text",
"text": [
"None of the examined objects belonged to the fourth Volkan 's group ( objects at hand when the news of the death came or objects present at the funeral , things that could be considered last - minute objects , ie , related to the moment when the deceased was last seen alive ) ."
],
"offsets": [
[
0,
278
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2115 | split_0_train_2115 | [
{
"id": "split_0_train_2115_passage",
"type": "progene_text",
"text": [
"However , 8 / 26 objects formed a new hitherto undescribed group ."
],
"offsets": [
[
0,
66
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2116 | split_0_train_2116 | [
{
"id": "split_0_train_2116_passage",
"type": "progene_text",
"text": [
"Mothers used such objects to create a memorial shrine to their sons ."
],
"offsets": [
[
0,
69
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2117 | split_0_train_2117 | [
{
"id": "split_0_train_2117_passage",
"type": "progene_text",
"text": [
"A photograph of the missing person or person whose remains were identified long after he had gone missing occupied a central place at the shrine , and was surrounded by other symbols of the Catholic iconography ( Virgin Mary , crucifix ) , flowers , and candles ."
],
"offsets": [
[
0,
263
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2118 | split_0_train_2118 | [
{
"id": "split_0_train_2118_passage",
"type": "progene_text",
"text": [
"The memorial shrine to the beloved son who disappeared was always located in the room where the family spent most of their time and/or where guests were received ( living room or kitchen ) ."
],
"offsets": [
[
0,
190
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2119 | split_0_train_2119 | [
{
"id": "split_0_train_2119_passage",
"type": "progene_text",
"text": [
"CONCLUSION :"
],
"offsets": [
[
0,
12
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2120 | split_0_train_2120 | [
{
"id": "split_0_train_2120_passage",
"type": "progene_text",
"text": [
"We found three out of four original ( Volkan 's) groups of linking objects , but also an additional one , hitherto undescribed , comprising objects used for designing a memorial shrine to the deceased ."
],
"offsets": [
[
0,
202
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2121 | split_0_train_2121 | [
{
"id": "split_0_train_2121_passage",
"type": "progene_text",
"text": [
"This could be viewed as an expression typical of Christian , mid - European Croatian culture and tradition ."
],
"offsets": [
[
0,
108
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2122 | split_0_train_2122 | [
{
"id": "split_0_train_2122_passage",
"type": "progene_text",
"text": [
"Oprelvekin ."
],
"offsets": [
[
0,
12
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2123 | split_0_train_2123 | [
{
"id": "split_0_train_2123_passage",
"type": "progene_text",
"text": [
"Genetics Institute ."
],
"offsets": [
[
0,
20
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2124 | split_0_train_2124 | [
{
"id": "split_0_train_2124_passage",
"type": "progene_text",
"text": [
"Genetics Institute has developed and launched oprelvekin ( rhIL-11 ; Neumega ) , a recombinant form of human IL-11 ."
],
"offsets": [
[
0,
116
]
]
}
]
| [
{
"id": "split_0_train_3184_entity",
"type": "progene_text",
"text": [
"rhIL-11"
],
"offsets": [
[
59,
66
]
],
"normalized": []
},
{
"id": "split_0_train_3185_entity",
"type": "progene_text",
"text": [
"IL-11"
],
"offsets": [
[
109,
114
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2125 | split_0_train_2125 | [
{
"id": "split_0_train_2125_passage",
"type": "progene_text",
"text": [
"In November 1997 , the FDA cleared oprelvekin for the prevention of severe thrombocytopenia and the reduction of the need for platelet transfusions following myelosuppressive chemotherapy in susceptible patients with non - myeloid malignancies 12703021 ."
],
"offsets": [
[
0,
254
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2126 | split_0_train_2126 | [
{
"id": "split_0_train_2126_passage",
"type": "progene_text",
"text": [
"The product was launched at the end of 1997 [ 312556 ] ."
],
"offsets": [
[
0,
56
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2127 | split_0_train_2127 | [
{
"id": "split_0_train_2127_passage",
"type": "progene_text",
"text": [
"By December 1999 , phase III trials for Crohn 's disease ( CD ) were underway [ 363007 ] ."
],
"offsets": [
[
0,
90
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2128 | split_0_train_2128 | [
{
"id": "split_0_train_2128_passage",
"type": "progene_text",
"text": [
"Genetics Institute had commenced a 150 - patient phase II trial for mild - to - moderate CD and mucositis and the company planned to file regulatory procedures for the indication of CD in 1999 [ 271210 ] ."
],
"offsets": [
[
0,
205
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2129 | split_0_train_2129 | [
{
"id": "split_0_train_2129_passage",
"type": "progene_text",
"text": [
"An oral formulation for this indication has been developed ."
],
"offsets": [
[
0,
60
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2130 | split_0_train_2130 | [
{
"id": "split_0_train_2130_passage",
"type": "progene_text",
"text": [
"Oprelvekin is also undergoing phase I clinical trials for colitis [ 396157 ] , phase II clinical trials for rheumatoid arthritis [ 413835 ] and clinical trials for psoriasis [ 299644 ] ."
],
"offsets": [
[
0,
186
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2131 | split_0_train_2131 | [
{
"id": "split_0_train_2131_passage",
"type": "progene_text",
"text": [
"In March 1997 , Wyeth - Ayerst became the licensee for Europe , Africa , Latin America and Asia ( with the exception of Japan ) ."
],
"offsets": [
[
0,
129
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2132 | split_0_train_2132 | [
{
"id": "split_0_train_2132_passage",
"type": "progene_text",
"text": [
"Genetics Institute holds marketing rights for North America [ 239273 ] ."
],
"offsets": [
[
0,
72
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2133 | split_0_train_2133 | [
{
"id": "split_0_train_2133_passage",
"type": "progene_text",
"text": [
"In Japan , oprelvekin is being developed by Genetics Institute and Yamanouchi ; phase III trials have commenced [ 295049 ] and were ongoing in May 2001 [ 411763 ] ."
],
"offsets": [
[
0,
164
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2134 | split_0_train_2134 | [
{
"id": "split_0_train_2134_passage",
"type": "progene_text",
"text": [
"In April 1996 , analysts at Yamaichi estimated launch in 2001 and maximum annual sales of over yen 10 billion [ 215896 ] ."
],
"offsets": [
[
0,
122
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2135 | split_0_train_2135 | [
{
"id": "split_0_train_2135_passage",
"type": "progene_text",
"text": [
"In January 1998 , Morgan Stanley Dean Witter predicted Yamanouchi 's share of sales to be yen 1 billion in 2001 , rising to yen 2 billion in 2002 [ 315458 ] ."
],
"offsets": [
[
0,
158
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2136 | split_0_train_2136 | [
{
"id": "split_0_train_2136_passage",
"type": "progene_text",
"text": [
"Sales of oprelvekin were US $34 million for Genetics institute in fiscal 2000 while , in July 2001 , Credit Suisse First Boston estimated that this figure will be US $30 million and US $34 million in 2001 and 2002 , respectively [ 416883 ] ."
],
"offsets": [
[
0,
241
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2137 | split_0_train_2137 | [
{
"id": "split_0_train_2137_passage",
"type": "progene_text",
"text": [
"Retrospective hospital - based searches for cases of acute flaccid paralysis ."
],
"offsets": [
[
0,
78
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2138 | split_0_train_2138 | [
{
"id": "split_0_train_2138_passage",
"type": "progene_text",
"text": [
"OBJECTIVE :"
],
"offsets": [
[
0,
11
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2139 | split_0_train_2139 | [
{
"id": "split_0_train_2139_passage",
"type": "progene_text",
"text": [
"Australia had to demonstrate adequate acute flaccid paralysis ( AFP ) surveillance by achieving a rate of one per 100,000 in children under the age of 15 to fulfil one of the requirements of the Regional Commission for the Certification of Poliomyelitis Eradication to be declared polio free ."
],
"offsets": [
[
0,
293
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2140 | split_0_train_2140 | [
{
"id": "split_0_train_2140_passage",
"type": "progene_text",
"text": [
"To increase the ascertainment rate of AFP cases , a hospital search was conducted to identify cases not reported to the active AFP surveillance ."
],
"offsets": [
[
0,
145
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2141 | split_0_train_2141 | [
{
"id": "split_0_train_2141_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2142 | split_0_train_2142 | [
{
"id": "split_0_train_2142_passage",
"type": "progene_text",
"text": [
"A computerised search of hospital admissions in New South Wales ( NSW ) and Western Australia ( WA ) on ICD-9 codes of Guillain Barr�© Syndrome ( GBS ) , unspecified encephalitis , poliomyelitis , vaccine - associated paralytic polio ( VAPP ) and flaccid paralysis was conducted for the period 1995 - 98 ."
],
"offsets": [
[
0,
307
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2143 | split_0_train_2143 | [
{
"id": "split_0_train_2143_passage",
"type": "progene_text",
"text": [
"Medical records of cases that were not reported to the active surveillance were reviewed in three hospitals of NSW and two hospitals in WA ."
],
"offsets": [
[
0,
140
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2144 | split_0_train_2144 | [
{
"id": "split_0_train_2144_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2145 | split_0_train_2145 | [
{
"id": "split_0_train_2145_passage",
"type": "progene_text",
"text": [
"Twenty additional cases recorded as GBS and five as transverse myelitis ( TM ) were identified through the searches , which increased the average four - year AFP rate from 1.0 to 1.4 per 100 , 000 in children under the age of 15 years in these two states and the overall AFP rate in Australia increased from 0.78 to 1.14 ."
],
"offsets": [
[
0,
322
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2146 | split_0_train_2146 | [
{
"id": "split_0_train_2146_passage",
"type": "progene_text",
"text": [
"There were no cases of polio or VAPP found ."
],
"offsets": [
[
0,
44
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2147 | split_0_train_2147 | [
{
"id": "split_0_train_2147_passage",
"type": "progene_text",
"text": [
"Nine cases of GBS and five of TM reported to the active AFP surveillance were not found in the hospital searches ."
],
"offsets": [
[
0,
114
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2148 | split_0_train_2148 | [
{
"id": "split_0_train_2148_passage",
"type": "progene_text",
"text": [
"CONCLUSION :"
],
"offsets": [
[
0,
12
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2149 | split_0_train_2149 | [
{
"id": "split_0_train_2149_passage",
"type": "progene_text",
"text": [
"A combination of active surveillance and hospital - based searches increased the investigated AFP rate , which fulfilled one of the certification requirements for Australia to be certified polio free ."
],
"offsets": [
[
0,
201
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2150 | split_0_train_2150 | [
{
"id": "split_0_train_2150_passage",
"type": "progene_text",
"text": [
"Implications :"
],
"offsets": [
[
0,
14
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2151 | split_0_train_2151 | [
{
"id": "split_0_train_2151_passage",
"type": "progene_text",
"text": [
"Until global certification is achieved , AFP surveillance needs to be improved to identify cases of importation of wild poliovirus ."
],
"offsets": [
[
0,
132
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2152 | split_0_train_2152 | [
{
"id": "split_0_train_2152_passage",
"type": "progene_text",
"text": [
"Data management in practice - based research ."
],
"offsets": [
[
0,
46
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2153 | split_0_train_2153 | [
{
"id": "split_0_train_2153_passage",
"type": "progene_text",
"text": [
"OBJECTIVE :"
],
"offsets": [
[
0,
11
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2154 | split_0_train_2154 | [
{
"id": "split_0_train_2154_passage",
"type": "progene_text",
"text": [
"Multi - site data collection is complex and requires an effective data management system ."
],
"offsets": [
[
0,
90
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2155 | split_0_train_2155 | [
{
"id": "split_0_train_2155_passage",
"type": "progene_text",
"text": [
"This article explores data management issues encountered in the design , conduct , and analysis of a research project involving 74 community - based sites and a central data management system ."
],
"offsets": [
[
0,
193
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2156 | split_0_train_2156 | [
{
"id": "split_0_train_2156_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2157 | split_0_train_2157 | [
{
"id": "split_0_train_2157_passage",
"type": "progene_text",
"text": [
"Once the data arrived at the central site , data integrity was maintained at a very high level ."
],
"offsets": [
[
0,
96
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2158 | split_0_train_2158 | [
{
"id": "split_0_train_2158_passage",
"type": "progene_text",
"text": [
"Issues encountered in our study on low back pain reflected the practice - based nature of the study and the limitations of finances , staff , and facilities ."
],
"offsets": [
[
0,
158
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2159 | split_0_train_2159 | [
{
"id": "split_0_train_2159_passage",
"type": "progene_text",
"text": [
"CONCLUSION :"
],
"offsets": [
[
0,
12
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2160 | split_0_train_2160 | [
{
"id": "split_0_train_2160_passage",
"type": "progene_text",
"text": [
"The task of converting a research protocol to actual procedures for data collection and data management can be very challenging ."
],
"offsets": [
[
0,
129
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2161 | split_0_train_2161 | [
{
"id": "split_0_train_2161_passage",
"type": "progene_text",
"text": [
"The importance of early recognition of the effort and resources needed for data management and quality - control procedures cannot be overestimated ."
],
"offsets": [
[
0,
149
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2162 | split_0_train_2162 | [
{
"id": "split_0_train_2162_passage",
"type": "progene_text",
"text": [
"Conformational change and destabilization of cataract gammaC - crystallin T5P mutant ."
],
"offsets": [
[
0,
86
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]
}
]
| [
{
"id": "split_0_train_3186_entity",
"type": "progene_text",
"text": [
"gammaC - crystallin"
],
"offsets": [
[
54,
73
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2163 | split_0_train_2163 | [
{
"id": "split_0_train_2163_passage",
"type": "progene_text",
"text": [
"Human lens gammaC-crystallin and T5P mutant were cloned , and their biophysical properties and thermodynamic stability were studied ."
],
"offsets": [
[
0,
133
]
]
}
]
| [
{
"id": "split_0_train_3187_entity",
"type": "progene_text",
"text": [
"gammaC-crystallin"
],
"offsets": [
[
11,
28
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2164 | split_0_train_2164 | [
{
"id": "split_0_train_2164_passage",
"type": "progene_text",
"text": [
"CRYGC ( T5P ) is one of the many gamma-crystallin mutant genes for autosomal dominant congenital cataracts ."
],
"offsets": [
[
0,
108
]
]
}
]
| [
{
"id": "split_0_train_3188_entity",
"type": "progene_text",
"text": [
"CRYGC"
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[
0,
5
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},
{
"id": "split_0_train_3189_entity",
"type": "progene_text",
"text": [
"gamma-crystallin"
],
"offsets": [
[
33,
49
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2165 | split_0_train_2165 | [
{
"id": "split_0_train_2165_passage",
"type": "progene_text",
"text": [
"This mutation is associated with Coppock - like cataract , and has the phenotype of a dust - like opacity of the fetal lens nucleus ."
],
"offsets": [
[
0,
133
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2166 | split_0_train_2166 | [
{
"id": "split_0_train_2166_passage",
"type": "progene_text",
"text": [
"During cloning and overexpression , the majority of T5P mutant was found in the inclusion body ."
],
"offsets": [
[
0,
96
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2167 | split_0_train_2167 | [
{
"id": "split_0_train_2167_passage",
"type": "progene_text",
"text": [
"This property is unique among the many cataract gamma-crystallin mutant genes ."
],
"offsets": [
[
0,
79
]
]
}
]
| [
{
"id": "split_0_train_3190_entity",
"type": "progene_text",
"text": [
"gamma-crystallin"
],
"offsets": [
[
48,
64
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2168 | split_0_train_2168 | [
{
"id": "split_0_train_2168_passage",
"type": "progene_text",
"text": [
"It is thus worthwhile to study what factors contribute to this unique property of gammaC-crystallin ."
],
"offsets": [
[
0,
101
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]
}
]
| [
{
"id": "split_0_train_3191_entity",
"type": "progene_text",
"text": [
"gammaC-crystallin"
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"offsets": [
[
82,
99
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2169 | split_0_train_2169 | [
{
"id": "split_0_train_2169_passage",
"type": "progene_text",
"text": [
"One possibility is changes in conformation and stability , which can be studied using spectroscopic measurements ."
],
"offsets": [
[
0,
114
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2170 | split_0_train_2170 | [
{
"id": "split_0_train_2170_passage",
"type": "progene_text",
"text": [
"In this study , conformational change was studied by circular dichroism and fluorescence measurements , and conformational stability was determined by thermal unfolding probed by Trp fluorescence and time - dependent light scattering ."
],
"offsets": [
[
0,
235
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2171 | split_0_train_2171 | [
{
"id": "split_0_train_2171_passage",
"type": "progene_text",
"text": [
"The T5P mutation obviously changes conformation and decreases conformational stability ."
],
"offsets": [
[
0,
88
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2172 | split_0_train_2172 | [
{
"id": "split_0_train_2172_passage",
"type": "progene_text",
"text": [
"Interaction of Alzheimer 's beta - amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade ."
],
"offsets": [
[
0,
122
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]
}
]
| [
{
"id": "split_0_train_3192_entity",
"type": "progene_text",
"text": [
"beta - amyloid precursor family"
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28,
59
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},
{
"id": "split_0_train_3193_entity",
"type": "progene_text",
"text": [
"JNK"
],
"offsets": [
[
99,
102
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2173 | split_0_train_2173 | [
{
"id": "split_0_train_2173_passage",
"type": "progene_text",
"text": [
"We have isolated a novel protein based on its association with Drosophila APP - like protein ( APPL ) , a homolog of the beta-amyloid precursor protein ( APP ) that is implicated in Alzheimer 's disease ."
],
"offsets": [
[
0,
204
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]
}
]
| [
{
"id": "split_0_train_3194_entity",
"type": "progene_text",
"text": [
"APP - like protein"
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"offsets": [
[
74,
92
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},
{
"id": "split_0_train_3195_entity",
"type": "progene_text",
"text": [
"APPL"
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"offsets": [
[
95,
99
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"normalized": []
},
{
"id": "split_0_train_3196_entity",
"type": "progene_text",
"text": [
"beta-amyloid precursor protein"
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"offsets": [
[
121,
151
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},
{
"id": "split_0_train_3197_entity",
"type": "progene_text",
"text": [
"APP"
],
"offsets": [
[
154,
157
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2174 | split_0_train_2174 | [
{
"id": "split_0_train_2174_passage",
"type": "progene_text",
"text": [
"This novel APPL - interacting protein 1 ( APLIP1 ) contains a Src homology 3 domain and a phosphotyrosine interaction domain and is expressed abundantly in neural tissues ."
],
"offsets": [
[
0,
172
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]
}
]
| [
{
"id": "split_0_train_3198_entity",
"type": "progene_text",
"text": [
"APPL - interacting protein 1"
],
"offsets": [
[
11,
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},
{
"id": "split_0_train_3199_entity",
"type": "progene_text",
"text": [
"APLIP1"
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"offsets": [
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42,
48
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},
{
"id": "split_0_train_3200_entity",
"type": "progene_text",
"text": [
"Src"
],
"offsets": [
[
62,
65
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2175 | split_0_train_2175 | [
{
"id": "split_0_train_2175_passage",
"type": "progene_text",
"text": [
"The phosphotyrosine interaction domain of APLIP1 interacts with a sequence containing GYENPTY in the cytoplasmic domain of APPL ."
],
"offsets": [
[
0,
129
]
]
}
]
| [
{
"id": "split_0_train_3201_entity",
"type": "progene_text",
"text": [
"APLIP1"
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"offsets": [
[
42,
48
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],
"normalized": []
},
{
"id": "split_0_train_3202_entity",
"type": "progene_text",
"text": [
"APPL"
],
"offsets": [
[
123,
127
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2176 | split_0_train_2176 | [
{
"id": "split_0_train_2176_passage",
"type": "progene_text",
"text": [
"APLIP1 is highly homologous to the carboxyl - terminal halves of mammalian c-Jun NH(2) - terminal kinase ( JNK ) - interacting protein 1b ( JIP1b ) and 2 ( JIP2 ) , which also contain Src homology 3 and phosphotyrosine interaction domains ."
],
"offsets": [
[
0,
240
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]
}
]
| [
{
"id": "split_0_train_3203_entity",
"type": "progene_text",
"text": [
"APLIP1"
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"offsets": [
[
0,
6
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],
"normalized": []
},
{
"id": "split_0_train_3204_entity",
"type": "progene_text",
"text": [
"c-Jun NH(2) - terminal kinase ( JNK ) - interacting protein 1b ( JIP1b ) and 2"
],
"offsets": [
[
75,
153
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],
"normalized": []
},
{
"id": "split_0_train_3205_entity",
"type": "progene_text",
"text": [
"JIP2"
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"offsets": [
[
156,
160
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],
"normalized": []
},
{
"id": "split_0_train_3206_entity",
"type": "progene_text",
"text": [
"Src"
],
"offsets": [
[
184,
187
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2177 | split_0_train_2177 | [
{
"id": "split_0_train_2177_passage",
"type": "progene_text",
"text": [
"The similarity of APLIP1 to JIP1b and JIP2 includes interaction with component(s) of the JNK signaling pathway and with the motor protein kinesin and the formation of homo - oligomers ."
],
"offsets": [
[
0,
185
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]
}
]
| [
{
"id": "split_0_train_3207_entity",
"type": "progene_text",
"text": [
"APLIP1"
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"offsets": [
[
18,
24
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"normalized": []
},
{
"id": "split_0_train_3208_entity",
"type": "progene_text",
"text": [
"JIP1b"
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"offsets": [
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28,
33
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"normalized": []
},
{
"id": "split_0_train_3209_entity",
"type": "progene_text",
"text": [
"JIP2"
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"offsets": [
[
38,
42
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],
"normalized": []
},
{
"id": "split_0_train_3210_entity",
"type": "progene_text",
"text": [
"JNK"
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[
89,
92
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],
"normalized": []
},
{
"id": "split_0_train_3211_entity",
"type": "progene_text",
"text": [
"motor protein"
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"offsets": [
[
124,
137
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],
"normalized": []
},
{
"id": "split_0_train_3212_entity",
"type": "progene_text",
"text": [
"kinesin"
],
"offsets": [
[
138,
145
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2178 | split_0_train_2178 | [
{
"id": "split_0_train_2178_passage",
"type": "progene_text",
"text": [
"JIP1b interacts strongly with the cytoplasmic domain of APP ( APPcyt ) , as APLIP1 does with APPL , but the interaction of JIP2 with APPcyt is weak ."
],
"offsets": [
[
0,
149
]
]
}
]
| [
{
"id": "split_0_train_3213_entity",
"type": "progene_text",
"text": [
"JIP1b"
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"offsets": [
[
0,
5
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],
"normalized": []
},
{
"id": "split_0_train_3214_entity",
"type": "progene_text",
"text": [
"APP"
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"offsets": [
[
56,
59
]
],
"normalized": []
},
{
"id": "split_0_train_3215_entity",
"type": "progene_text",
"text": [
"APPcyt"
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"offsets": [
[
62,
68
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],
"normalized": []
},
{
"id": "split_0_train_3216_entity",
"type": "progene_text",
"text": [
"APLIP1"
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"offsets": [
[
76,
82
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],
"normalized": []
},
{
"id": "split_0_train_3217_entity",
"type": "progene_text",
"text": [
"APPL"
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"offsets": [
[
93,
97
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],
"normalized": []
},
{
"id": "split_0_train_3218_entity",
"type": "progene_text",
"text": [
"JIP2"
],
"offsets": [
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123,
127
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],
"normalized": []
},
{
"id": "split_0_train_3219_entity",
"type": "progene_text",
"text": [
"APPcyt"
],
"offsets": [
[
133,
139
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2179 | split_0_train_2179 | [
{
"id": "split_0_train_2179_passage",
"type": "progene_text",
"text": [
"Overexpression of JIP1b slightly enhances the JNK - dependent threonine phosphorylation of APP in cultured cells , but that of JIP2 suppresses it ."
],
"offsets": [
[
0,
147
]
]
}
]
| [
{
"id": "split_0_train_3220_entity",
"type": "progene_text",
"text": [
"JIP1b"
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"offsets": [
[
18,
23
]
],
"normalized": []
},
{
"id": "split_0_train_3221_entity",
"type": "progene_text",
"text": [
"JNK"
],
"offsets": [
[
46,
49
]
],
"normalized": []
},
{
"id": "split_0_train_3222_entity",
"type": "progene_text",
"text": [
"APP"
],
"offsets": [
[
91,
94
]
],
"normalized": []
},
{
"id": "split_0_train_3223_entity",
"type": "progene_text",
"text": [
"JIP2"
],
"offsets": [
[
127,
131
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2180 | split_0_train_2180 | [
{
"id": "split_0_train_2180_passage",
"type": "progene_text",
"text": [
"These observations suggest that the interactions of APP family proteins with APLIP1 , JIP1b , and JIP2 are conserved and play important roles in the metabolism and/or the function of APPs including the regulation of APP phosphorylation by JNK ."
],
"offsets": [
[
0,
244
]
]
}
]
| [
{
"id": "split_0_train_3224_entity",
"type": "progene_text",
"text": [
"APP family"
],
"offsets": [
[
52,
62
]
],
"normalized": []
},
{
"id": "split_0_train_3225_entity",
"type": "progene_text",
"text": [
"APLIP1"
],
"offsets": [
[
77,
83
]
],
"normalized": []
},
{
"id": "split_0_train_3226_entity",
"type": "progene_text",
"text": [
"JIP1b"
],
"offsets": [
[
86,
91
]
],
"normalized": []
},
{
"id": "split_0_train_3227_entity",
"type": "progene_text",
"text": [
"JIP2"
],
"offsets": [
[
98,
102
]
],
"normalized": []
},
{
"id": "split_0_train_3228_entity",
"type": "progene_text",
"text": [
"APPs"
],
"offsets": [
[
183,
187
]
],
"normalized": []
},
{
"id": "split_0_train_3229_entity",
"type": "progene_text",
"text": [
"APP"
],
"offsets": [
[
216,
219
]
],
"normalized": []
},
{
"id": "split_0_train_3230_entity",
"type": "progene_text",
"text": [
"JNK"
],
"offsets": [
[
239,
242
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2181 | split_0_train_2181 | [
{
"id": "split_0_train_2181_passage",
"type": "progene_text",
"text": [
"Analysis of APP family proteins and their associated proteins is expected to contribute to understanding the molecular process of neural degeneration in Alzheimer 's disease ."
],
"offsets": [
[
0,
175
]
]
}
]
| [
{
"id": "split_0_train_3231_entity",
"type": "progene_text",
"text": [
"APP family"
],
"offsets": [
[
12,
22
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2182 | split_0_train_2182 | [
{
"id": "split_0_train_2182_passage",
"type": "progene_text",
"text": [
"Results of the Lynn Sage Second - Opinion Program for local therapy in patients with breast carcinoma ."
],
"offsets": [
[
0,
103
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2183 | split_0_train_2183 | [
{
"id": "split_0_train_2183_passage",
"type": "progene_text",
"text": [
"Changes in management and determinants of where care is delivered ."
],
"offsets": [
[
0,
67
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2184 | split_0_train_2184 | [
{
"id": "split_0_train_2184_passage",
"type": "progene_text",
"text": [
"BACKGROUND :"
],
"offsets": [
[
0,
12
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2185 | split_0_train_2185 | [
{
"id": "split_0_train_2185_passage",
"type": "progene_text",
"text": [
"The treatment options of breast conservation therapy ( BCT ) and immediate reconstruction for patients with carcinoma of the breast have not been adopted widely ."
],
"offsets": [
[
0,
162
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2186 | split_0_train_2186 | [
{
"id": "split_0_train_2186_passage",
"type": "progene_text",
"text": [
"The objectives of this study were to determine how often a second opinion on the local therapy of breast carcinoma changed patient management and to identify factors predictive of remaining at the second - opinion site for therapy ."
],
"offsets": [
[
0,
232
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2187 | split_0_train_2187 | [
{
"id": "split_0_train_2187_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2188 | split_0_train_2188 | [
{
"id": "split_0_train_2188_passage",
"type": "progene_text",
"text": [
"Two hundred thirty-one patients with intraductal carcinoma or Stage I and II breast carcinoma were reviewed retrospectively ."
],
"offsets": [
[
0,
125
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2189 | split_0_train_2189 | [
{
"id": "split_0_train_2189_passage",
"type": "progene_text",
"text": [
"At the time of the second opinion , patients completed a questionnaire regarding their initial surgical opinion and the reason for seeking consultation ."
],
"offsets": [
[
0,
153
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2190 | split_0_train_2190 | [
{
"id": "split_0_train_2190_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2191 | split_0_train_2191 | [
{
"id": "split_0_train_2191_passage",
"type": "progene_text",
"text": [
"Only 46 % of patients had a complete discussion of treatment options prior to the second opinion ."
],
"offsets": [
[
0,
98
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2192 | split_0_train_2192 | [
{
"id": "split_0_train_2192_passage",
"type": "progene_text",
"text": [
"The second opinion changed management in 54 patients ( 20.3 % ) ."
],
"offsets": [
[
0,
65
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2193 | split_0_train_2193 | [
{
"id": "split_0_train_2193_passage",
"type": "progene_text",
"text": [
"The most common finding was eligibility for BCT in patients who were offered only mastectomy ."
],
"offsets": [
[
0,
94
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2194 | split_0_train_2194 | [
{
"id": "split_0_train_2194_passage",
"type": "progene_text",
"text": [
"Definitive local therapy occurred at the second - opinion site in 65.8 % of patients ."
],
"offsets": [
[
0,
86
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2195 | split_0_train_2195 | [
{
"id": "split_0_train_2195_passage",
"type": "progene_text",
"text": [
"The only predictors of remaining at the second - opinion site were insurance type ( P = 0.008 ) and the patient 's perception that options were not discussed at the initial opinion ( P < 0.001 ) ."
],
"offsets": [
[
0,
196
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2196 | split_0_train_2196 | [
{
"id": "split_0_train_2196_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2197 | split_0_train_2197 | [
{
"id": "split_0_train_2197_passage",
"type": "progene_text",
"text": [
"Second opinions provide useful information to patients and may change the management of their disease ."
],
"offsets": [
[
0,
103
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2198 | split_0_train_2198 | [
{
"id": "split_0_train_2198_passage",
"type": "progene_text",
"text": [
"They result in significant patient capture for an institution ."
],
"offsets": [
[
0,
63
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2199 | split_0_train_2199 | [
{
"id": "split_0_train_2199_passage",
"type": "progene_text",
"text": [
"Distinct expression pattern of two related human proteins containing multiple types of protease - inhibitory modules ."
],
"offsets": [
[
0,
118
]
]
}
]
| [
{
"id": "split_0_train_3232_entity",
"type": "progene_text",
"text": [
"protease"
],
"offsets": [
[
87,
95
]
],
"normalized": []
}
]
| []
| []
| []
|
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