id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_1800 | split_0_train_1800 | [
{
"id": "split_0_train_1800_passage",
"type": "progene_text",
"text": [
"The Drosophila genome does not have orthologs for the salvage pathway enzymes , i.e. fucokinase and GDP - fucose pyrophosphorylase synthesizing GDP - fucose from fucose ."
],
"offsets": [
[
0,
170
]
]
}
]
| [
{
"id": "split_0_train_2746_entity",
"type": "progene_text",
"text": [
"GDP - fucose pyrophosphorylase"
],
"offsets": [
[
100,
130
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1801 | split_0_train_1801 | [
{
"id": "split_0_train_1801_passage",
"type": "progene_text",
"text": [
"In addition we identified two novel fucosyltransferases predicted to catalyze alpha1,3 - and alpha1 , 6 - specific linkages to the GlcNAc residues on glycans ."
],
"offsets": [
[
0,
159
]
]
}
]
| [
{
"id": "split_0_train_2747_entity",
"type": "progene_text",
"text": [
"fucosyltransferases"
],
"offsets": [
[
36,
55
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1802 | split_0_train_1802 | [
{
"id": "split_0_train_1802_passage",
"type": "progene_text",
"text": [
"No genes with the capacity to encode alpha1,2 - specific fucosyltransferases were found ."
],
"offsets": [
[
0,
89
]
]
}
]
| [
{
"id": "split_0_train_2748_entity",
"type": "progene_text",
"text": [
"fucosyltransferases"
],
"offsets": [
[
57,
76
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1803 | split_0_train_1803 | [
{
"id": "split_0_train_1803_passage",
"type": "progene_text",
"text": [
"We also identified two novel genes coding for O-fucosyltransferases and a gene responsible for a fucosidase enzyme in the Drosophila genome ."
],
"offsets": [
[
0,
141
]
]
}
]
| [
{
"id": "split_0_train_2749_entity",
"type": "progene_text",
"text": [
"O-fucosyltransferases"
],
"offsets": [
[
46,
67
]
],
"normalized": []
},
{
"id": "split_0_train_2750_entity",
"type": "progene_text",
"text": [
"fucosidase"
],
"offsets": [
[
97,
107
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1804 | split_0_train_1804 | [
{
"id": "split_0_train_1804_passage",
"type": "progene_text",
"text": [
"Finally , using the Drosophila CG4435 gene , we identified two novel human genes putatively coding for fucosyltransferases ."
],
"offsets": [
[
0,
124
]
]
}
]
| [
{
"id": "split_0_train_2751_entity",
"type": "progene_text",
"text": [
"CG4435"
],
"offsets": [
[
31,
37
]
],
"normalized": []
},
{
"id": "split_0_train_2752_entity",
"type": "progene_text",
"text": [
"fucosyltransferases"
],
"offsets": [
[
103,
122
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1805 | split_0_train_1805 | [
{
"id": "split_0_train_1805_passage",
"type": "progene_text",
"text": [
"This work can serve as a basis for further whole - genome approaches in mapping all possible glycosylation pathways and as a basic analysis leading to subsequent experimental studies to verify the predictions made in this work ."
],
"offsets": [
[
0,
228
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1806 | split_0_train_1806 | [
{
"id": "split_0_train_1806_passage",
"type": "progene_text",
"text": [
"A randomized , double - blind , placebo - controlled study with diethylcarbamazine for the treatment of hydrocoele in an area of Tanzania endemic for lymphatic filariasis ."
],
"offsets": [
[
0,
172
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1807 | split_0_train_1807 | [
{
"id": "split_0_train_1807_passage",
"type": "progene_text",
"text": [
"Hydrocoele is common in men in Wuchereria bancrofti - endemic areas , the treatment for which is currently surgical intervention ."
],
"offsets": [
[
0,
130
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1808 | split_0_train_1808 | [
{
"id": "split_0_train_1808_passage",
"type": "progene_text",
"text": [
"Two community studies have recently suggested that the antifilarial drug diethylcarbamazine ( DEC ) may have a beneficial effect of reducing the size of hydrocoeles of filarial origin ."
],
"offsets": [
[
0,
185
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1809 | split_0_train_1809 | [
{
"id": "split_0_train_1809_passage",
"type": "progene_text",
"text": [
"To test this hypothesis , a double - blind , placebo - controlled study was carried out in 1998 and 1999 in an area of north - eastern Tanzania where microfilaria ( mf ) carrier rates and hydrocoele prevalence rates were known to be high ."
],
"offsets": [
[
0,
239
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1810 | split_0_train_1810 | [
{
"id": "split_0_train_1810_passage",
"type": "progene_text",
"text": [
"Ninety-eight adult male volunteers ( aged > or = 15 years ) with chronic hydrocoele received DEC 300 mg per day for 12 days ( 49 patients ) , or placebo ( 49 patients ) ."
],
"offsets": [
[
0,
170
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1811 | split_0_train_1811 | [
{
"id": "split_0_train_1811_passage",
"type": "progene_text",
"text": [
"Circumferential and ultrasonographic measurements of the scrotum , and a serum sample for measuring W. bancrofti antigen , were obtained at the onset and after 3 , 6 and 12 months ."
],
"offsets": [
[
0,
181
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1812 | split_0_train_1812 | [
{
"id": "split_0_train_1812_passage",
"type": "progene_text",
"text": [
"Scrotal size and hydrocoele fluid volume indices were calculated ."
],
"offsets": [
[
0,
66
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1813 | split_0_train_1813 | [
{
"id": "split_0_train_1813_passage",
"type": "progene_text",
"text": [
"No statistically significant differences in volumetric measurements between the DEC and placebo groups were found at any of the follow - ups ."
],
"offsets": [
[
0,
142
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1814 | split_0_train_1814 | [
{
"id": "split_0_train_1814_passage",
"type": "progene_text",
"text": [
"Separate analyses dividing patients by antigen status , hydrocoele size or presence of thickening of the scrotal skins gave similar results ."
],
"offsets": [
[
0,
141
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1815 | split_0_train_1815 | [
{
"id": "split_0_train_1815_passage",
"type": "progene_text",
"text": [
"Geometric mean intensity of W. bancrofti antigen was significantly lower in the DEC group than in the placebo group ( P = 0.008 ) , indicating that lack of compliance was not a significant factor ."
],
"offsets": [
[
0,
197
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1816 | split_0_train_1816 | [
{
"id": "split_0_train_1816_passage",
"type": "progene_text",
"text": [
"Two months into the treatment trial , mass treatment with monthly low - dose DEC was given to the rest of the community ."
],
"offsets": [
[
0,
121
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1817 | split_0_train_1817 | [
{
"id": "split_0_train_1817_passage",
"type": "progene_text",
"text": [
"We conclude that DEC is not effective in reducing the size of hydrocoele of filarial origin ."
],
"offsets": [
[
0,
93
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1818 | split_0_train_1818 | [
{
"id": "split_0_train_1818_passage",
"type": "progene_text",
"text": [
"Interventions to replace or supplement hydrocoelectomy should be investigated ."
],
"offsets": [
[
0,
79
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1819 | split_0_train_1819 | [
{
"id": "split_0_train_1819_passage",
"type": "progene_text",
"text": [
"Differential regulation of T cell receptor - mediated Th1 cell IFN-gamma production and proliferation by divergent cAMP - mediated redox pathways ."
],
"offsets": [
[
0,
147
]
]
}
]
| [
{
"id": "split_0_train_2753_entity",
"type": "progene_text",
"text": [
"T cell receptor"
],
"offsets": [
[
27,
42
]
],
"normalized": []
},
{
"id": "split_0_train_2754_entity",
"type": "progene_text",
"text": [
"IFN-gamma"
],
"offsets": [
[
63,
72
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1820 | split_0_train_1820 | [
{
"id": "split_0_train_1820_passage",
"type": "progene_text",
"text": [
"Culture of an H-2(s) - restricted , bovine myelin basic protein ( BMBP ) - specific murine Th1 clone with the adenyl cyclase agonist forskolin ( FSK ) or isobutylmethylxanthine ( IBMX ) , an inhibitor of cAMP catabolism , before culture with anti - CD3 or BMBP and antigen - presenting cells ( APC ) suppressed antigen or anti - CD3 - induced proliferation and production of interferon-gamma ( IFN-gamma ) ."
],
"offsets": [
[
0,
407
]
]
}
]
| [
{
"id": "split_0_train_2755_entity",
"type": "progene_text",
"text": [
"myelin basic protein"
],
"offsets": [
[
43,
63
]
],
"normalized": []
},
{
"id": "split_0_train_2756_entity",
"type": "progene_text",
"text": [
"BMBP"
],
"offsets": [
[
66,
70
]
],
"normalized": []
},
{
"id": "split_0_train_2757_entity",
"type": "progene_text",
"text": [
"adenyl cyclase"
],
"offsets": [
[
110,
124
]
],
"normalized": []
},
{
"id": "split_0_train_2758_entity",
"type": "progene_text",
"text": [
"CD3"
],
"offsets": [
[
249,
252
]
],
"normalized": []
},
{
"id": "split_0_train_2759_entity",
"type": "progene_text",
"text": [
"BMBP"
],
"offsets": [
[
256,
260
]
],
"normalized": []
},
{
"id": "split_0_train_2760_entity",
"type": "progene_text",
"text": [
"CD3"
],
"offsets": [
[
329,
332
]
],
"normalized": []
},
{
"id": "split_0_train_2761_entity",
"type": "progene_text",
"text": [
"interferon-gamma"
],
"offsets": [
[
375,
391
]
],
"normalized": []
},
{
"id": "split_0_train_2762_entity",
"type": "progene_text",
"text": [
"IFN-gamma"
],
"offsets": [
[
394,
403
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1821 | split_0_train_1821 | [
{
"id": "split_0_train_1821_passage",
"type": "progene_text",
"text": [
"Other H-2 (s) - derived or H-2 ( b ) - derived clones specific for BMBP or keyhole limpet hemocyanin ( KLH ) were similarly affected ."
],
"offsets": [
[
0,
134
]
]
}
]
| [
{
"id": "split_0_train_2763_entity",
"type": "progene_text",
"text": [
"H-2"
],
"offsets": [
[
6,
9
]
],
"normalized": []
},
{
"id": "split_0_train_2764_entity",
"type": "progene_text",
"text": [
"H-2"
],
"offsets": [
[
27,
30
]
],
"normalized": []
},
{
"id": "split_0_train_2765_entity",
"type": "progene_text",
"text": [
"BMBP"
],
"offsets": [
[
67,
71
]
],
"normalized": []
},
{
"id": "split_0_train_2766_entity",
"type": "progene_text",
"text": [
"hemocyanin"
],
"offsets": [
[
90,
100
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1822 | split_0_train_1822 | [
{
"id": "split_0_train_1822_passage",
"type": "progene_text",
"text": [
"FSK did not affect the expression of CD4 or the T cell receptor ( TCR ) but did diminish levels of the phosphorylated ( activated ) mitogen - activated protein ( MAP ) kinases early response kinase-1 ( ERK-1 ) and ERK-2 ."
],
"offsets": [
[
0,
221
]
]
}
]
| [
{
"id": "split_0_train_2767_entity",
"type": "progene_text",
"text": [
"CD4"
],
"offsets": [
[
37,
40
]
],
"normalized": []
},
{
"id": "split_0_train_2768_entity",
"type": "progene_text",
"text": [
"T cell receptor"
],
"offsets": [
[
48,
63
]
],
"normalized": []
},
{
"id": "split_0_train_2769_entity",
"type": "progene_text",
"text": [
"TCR"
],
"offsets": [
[
66,
69
]
],
"normalized": []
},
{
"id": "split_0_train_2770_entity",
"type": "progene_text",
"text": [
"mitogen - activated protein ( MAP ) kinases"
],
"offsets": [
[
132,
175
]
],
"normalized": []
},
{
"id": "split_0_train_2771_entity",
"type": "progene_text",
"text": [
"early response kinase-1"
],
"offsets": [
[
176,
199
]
],
"normalized": []
},
{
"id": "split_0_train_2772_entity",
"type": "progene_text",
"text": [
"ERK-1"
],
"offsets": [
[
202,
207
]
],
"normalized": []
},
{
"id": "split_0_train_2773_entity",
"type": "progene_text",
"text": [
"ERK-2"
],
"offsets": [
[
214,
219
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1823 | split_0_train_1823 | [
{
"id": "split_0_train_1823_passage",
"type": "progene_text",
"text": [
"Immunoblotting of lysates from an FSK - treated Th1 clone with antibodies to a carboxy - terminal epitope of p56 ( lck ) , a signal transduction enzyme upstream from ERK-1 and ERK2 , did not detect p56 ( lck ) unless the lysates were reduced prior to electrophoresis ."
],
"offsets": [
[
0,
268
]
]
}
]
| [
{
"id": "split_0_train_2774_entity",
"type": "progene_text",
"text": [
"p56 ( lck )"
],
"offsets": [
[
109,
120
]
],
"normalized": []
},
{
"id": "split_0_train_2775_entity",
"type": "progene_text",
"text": [
"ERK-1"
],
"offsets": [
[
166,
171
]
],
"normalized": []
},
{
"id": "split_0_train_2776_entity",
"type": "progene_text",
"text": [
"ERK2"
],
"offsets": [
[
176,
180
]
],
"normalized": []
},
{
"id": "split_0_train_2777_entity",
"type": "progene_text",
"text": [
"p56 ( lck )"
],
"offsets": [
[
198,
209
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1824 | split_0_train_1824 | [
{
"id": "split_0_train_1824_passage",
"type": "progene_text",
"text": [
"Immunoblotting of nonreduced lysates with antibodies to an amino - terminal epitope demonstrated p56 ( lck ) with a lower apparent molecular weight , characteristic of oxidized proteins ."
],
"offsets": [
[
0,
187
]
]
}
]
| [
{
"id": "split_0_train_2778_entity",
"type": "progene_text",
"text": [
"p56 ( lck )"
],
"offsets": [
[
97,
108
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1825 | split_0_train_1825 | [
{
"id": "split_0_train_1825_passage",
"type": "progene_text",
"text": [
"Reduction restored the detection of p56(lck) by anticarboxy - terminal p56 ( lck ) and to mobilities indistinguishable from controls detected by the antiamino - terminal p56 ( lck ) ."
],
"offsets": [
[
0,
183
]
]
}
]
| [
{
"id": "split_0_train_2779_entity",
"type": "progene_text",
"text": [
"p56(lck)"
],
"offsets": [
[
36,
44
]
],
"normalized": []
},
{
"id": "split_0_train_2780_entity",
"type": "progene_text",
"text": [
"p56 ( lck )"
],
"offsets": [
[
71,
82
]
],
"normalized": []
},
{
"id": "split_0_train_2781_entity",
"type": "progene_text",
"text": [
"p56 ( lck )"
],
"offsets": [
[
170,
181
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1826 | split_0_train_1826 | [
{
"id": "split_0_train_1826_passage",
"type": "progene_text",
"text": [
"N-acetylcysteine or catalase prevented FSK - induced suppression of antigen - induced proliferation and the loss of carboxy - terminal epitopes of p56 ( lck ) ."
],
"offsets": [
[
0,
160
]
]
}
]
| [
{
"id": "split_0_train_2782_entity",
"type": "progene_text",
"text": [
"catalase"
],
"offsets": [
[
20,
28
]
],
"normalized": []
},
{
"id": "split_0_train_2783_entity",
"type": "progene_text",
"text": [
"p56 ( lck )"
],
"offsets": [
[
147,
158
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1827 | split_0_train_1827 | [
{
"id": "split_0_train_1827_passage",
"type": "progene_text",
"text": [
"An inhibitor of cAMP - dependent protein kinase A ( PKA ) or nitric oxide synthase ( NOS ) did not affect FSK - induced inhibition of antigen - induced proliferation ."
],
"offsets": [
[
0,
167
]
]
}
]
| [
{
"id": "split_0_train_2784_entity",
"type": "progene_text",
"text": [
"cAMP - dependent protein kinase A"
],
"offsets": [
[
16,
49
]
],
"normalized": []
},
{
"id": "split_0_train_2785_entity",
"type": "progene_text",
"text": [
"PKA"
],
"offsets": [
[
52,
55
]
],
"normalized": []
},
{
"id": "split_0_train_2786_entity",
"type": "progene_text",
"text": [
"nitric oxide synthase"
],
"offsets": [
[
61,
82
]
],
"normalized": []
},
{
"id": "split_0_train_2787_entity",
"type": "progene_text",
"text": [
"NOS"
],
"offsets": [
[
85,
88
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1828 | split_0_train_1828 | [
{
"id": "split_0_train_1828_passage",
"type": "progene_text",
"text": [
"In contrast , inhibitors of PKA or NOS , but not catalase , prevented FSK - induced suppression of IFN-gamma production ."
],
"offsets": [
[
0,
121
]
]
}
]
| [
{
"id": "split_0_train_2788_entity",
"type": "progene_text",
"text": [
"PKA"
],
"offsets": [
[
28,
31
]
],
"normalized": []
},
{
"id": "split_0_train_2789_entity",
"type": "progene_text",
"text": [
"NOS"
],
"offsets": [
[
35,
38
]
],
"normalized": []
},
{
"id": "split_0_train_2790_entity",
"type": "progene_text",
"text": [
"catalase"
],
"offsets": [
[
49,
57
]
],
"normalized": []
},
{
"id": "split_0_train_2791_entity",
"type": "progene_text",
"text": [
"IFN-gamma"
],
"offsets": [
[
99,
108
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1829 | split_0_train_1829 | [
{
"id": "split_0_train_1829_passage",
"type": "progene_text",
"text": [
"Moreover , immunoblots of lysates precipitated with anti - p56 ( lck ) , phosphotyrosine , or CD4 demonstrated that in FSK - treated , anti - CD3 - stimulated cells , p56 ( lck ) is not associated with CD4 zeta chain , nor is p56 ( lck ) or zeta chain phosphorylated ."
],
"offsets": [
[
0,
268
]
]
}
]
| [
{
"id": "split_0_train_2792_entity",
"type": "progene_text",
"text": [
"p56 ( lck )"
],
"offsets": [
[
59,
70
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],
"normalized": []
},
{
"id": "split_0_train_2793_entity",
"type": "progene_text",
"text": [
"CD4"
],
"offsets": [
[
94,
97
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],
"normalized": []
},
{
"id": "split_0_train_2794_entity",
"type": "progene_text",
"text": [
"CD3"
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"offsets": [
[
142,
145
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"normalized": []
},
{
"id": "split_0_train_2795_entity",
"type": "progene_text",
"text": [
"p56 ( lck )"
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"offsets": [
[
167,
178
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},
{
"id": "split_0_train_2796_entity",
"type": "progene_text",
"text": [
"CD4"
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[
202,
205
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],
"normalized": []
},
{
"id": "split_0_train_2797_entity",
"type": "progene_text",
"text": [
"p56 ( lck )"
],
"offsets": [
[
226,
237
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1830 | split_0_train_1830 | [
{
"id": "split_0_train_1830_passage",
"type": "progene_text",
"text": [
"In vitro kinase assays demonstrated that p56 ( lck ) from FSK - treated cells does not have kinase activity ."
],
"offsets": [
[
0,
109
]
]
}
]
| [
{
"id": "split_0_train_2798_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
9,
15
]
],
"normalized": []
},
{
"id": "split_0_train_2799_entity",
"type": "progene_text",
"text": [
"p56 ( lck )"
],
"offsets": [
[
41,
52
]
],
"normalized": []
},
{
"id": "split_0_train_2800_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
92,
98
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1831 | split_0_train_1831 | [
{
"id": "split_0_train_1831_passage",
"type": "progene_text",
"text": [
"Taken together , the results suggest that an elevation of intracellular cAMP ( in the absence of antigen ) creates an oxidative environment that oxidizes and inactivates p56 ( lck ) by an H(2)O(2) - dependent , PKA - independent mechanism and inhibits the production of IFN-gamma by an NO , PKA - dependent mechanism ."
],
"offsets": [
[
0,
318
]
]
}
]
| [
{
"id": "split_0_train_2801_entity",
"type": "progene_text",
"text": [
"p56 ( lck )"
],
"offsets": [
[
170,
181
]
],
"normalized": []
},
{
"id": "split_0_train_2802_entity",
"type": "progene_text",
"text": [
"PKA"
],
"offsets": [
[
211,
214
]
],
"normalized": []
},
{
"id": "split_0_train_2803_entity",
"type": "progene_text",
"text": [
"IFN-gamma"
],
"offsets": [
[
270,
279
]
],
"normalized": []
},
{
"id": "split_0_train_2804_entity",
"type": "progene_text",
"text": [
"PKA"
],
"offsets": [
[
291,
294
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1832 | split_0_train_1832 | [
{
"id": "split_0_train_1832_passage",
"type": "progene_text",
"text": [
"Thus , antigen - induced proliferation and IFN-gamma production in a Th1 clone are controlled separately by different cAMP - dependent , redox - based mechanisms ."
],
"offsets": [
[
0,
163
]
]
}
]
| [
{
"id": "split_0_train_2805_entity",
"type": "progene_text",
"text": [
"IFN-gamma"
],
"offsets": [
[
43,
52
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1833 | split_0_train_1833 | [
{
"id": "split_0_train_1833_passage",
"type": "progene_text",
"text": [
"Hyaluronate receptors mediating glioma cell migration and proliferation ."
],
"offsets": [
[
0,
73
]
]
}
]
| [
{
"id": "split_0_train_2806_entity",
"type": "progene_text",
"text": [
"Hyaluronate receptors"
],
"offsets": [
[
0,
21
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1834 | split_0_train_1834 | [
{
"id": "split_0_train_1834_passage",
"type": "progene_text",
"text": [
"The extracellular matrix ( ECM ) of the central nervous system ( CNS ) is enriched in hyaluronate ( HA ) ."
],
"offsets": [
[
0,
106
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1835 | split_0_train_1835 | [
{
"id": "split_0_train_1835_passage",
"type": "progene_text",
"text": [
"Ubiquitous receptors for HA are CD44 and the Receptor for HA-Mediated Motility known as RHAMM ."
],
"offsets": [
[
0,
95
]
]
}
]
| [
{
"id": "split_0_train_2807_entity",
"type": "progene_text",
"text": [
"CD44"
],
"offsets": [
[
32,
36
]
],
"normalized": []
},
{
"id": "split_0_train_2808_entity",
"type": "progene_text",
"text": [
"Receptor for HA-Mediated Motility"
],
"offsets": [
[
45,
78
]
],
"normalized": []
},
{
"id": "split_0_train_2809_entity",
"type": "progene_text",
"text": [
"RHAMM"
],
"offsets": [
[
88,
93
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1836 | split_0_train_1836 | [
{
"id": "split_0_train_1836_passage",
"type": "progene_text",
"text": [
"In the present study , we have investigated the potential role of CD44 and RHAMM in the migration and proliferation of human astrocytoma cells ."
],
"offsets": [
[
0,
144
]
]
}
]
| [
{
"id": "split_0_train_2810_entity",
"type": "progene_text",
"text": [
"CD44"
],
"offsets": [
[
66,
70
]
],
"normalized": []
},
{
"id": "split_0_train_2811_entity",
"type": "progene_text",
"text": [
"RHAMM"
],
"offsets": [
[
75,
80
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1837 | split_0_train_1837 | [
{
"id": "split_0_train_1837_passage",
"type": "progene_text",
"text": [
"HA - receptor expression in brain tumor cell lines and surgical specimens was determined by immunocytochemistry and western blot analyses ."
],
"offsets": [
[
0,
139
]
]
}
]
| [
{
"id": "split_0_train_2812_entity",
"type": "progene_text",
"text": [
"HA - receptor"
],
"offsets": [
[
0,
13
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1838 | split_0_train_1838 | [
{
"id": "split_0_train_1838_passage",
"type": "progene_text",
"text": [
"The ability of RHAMM to bind ligand was determined through cetylpyridinium chloride ( CPC ) precipitations of brain tumor lysates in HA - binding assays ."
],
"offsets": [
[
0,
154
]
]
}
]
| [
{
"id": "split_0_train_2813_entity",
"type": "progene_text",
"text": [
"RHAMM"
],
"offsets": [
[
15,
20
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1839 | split_0_train_1839 | [
{
"id": "split_0_train_1839_passage",
"type": "progene_text",
"text": [
"The effects of HA , CD44 blocking antibodies , and RHAMM soluble peptide on astrocytoma cell growth and migration was determined using MTT and migration assays ."
],
"offsets": [
[
0,
161
]
]
}
]
| [
{
"id": "split_0_train_2814_entity",
"type": "progene_text",
"text": [
"CD44"
],
"offsets": [
[
20,
24
]
],
"normalized": []
},
{
"id": "split_0_train_2815_entity",
"type": "progene_text",
"text": [
"RHAMM"
],
"offsets": [
[
51,
56
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1840 | split_0_train_1840 | [
{
"id": "split_0_train_1840_passage",
"type": "progene_text",
"text": [
"Our results show that the expression of the HA - receptors , CD44 , and RHAMM , is virtually ubiquitous amongst glioma cell lines , and glioma tumor specimens ."
],
"offsets": [
[
0,
160
]
]
}
]
| [
{
"id": "split_0_train_2816_entity",
"type": "progene_text",
"text": [
"HA - receptors"
],
"offsets": [
[
44,
58
]
],
"normalized": []
},
{
"id": "split_0_train_2817_entity",
"type": "progene_text",
"text": [
"CD44"
],
"offsets": [
[
61,
65
]
],
"normalized": []
},
{
"id": "split_0_train_2818_entity",
"type": "progene_text",
"text": [
"RHAMM"
],
"offsets": [
[
72,
77
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1841 | split_0_train_1841 | [
{
"id": "split_0_train_1841_passage",
"type": "progene_text",
"text": [
"There was a gradient of expression amongst gliomas with high grade gliomas expressing more RHAMM and CD44 than did lower grade lesions or did normal human astrocytes or non - neoplastic specimens of human brain ."
],
"offsets": [
[
0,
212
]
]
}
]
| [
{
"id": "split_0_train_2819_entity",
"type": "progene_text",
"text": [
"RHAMM"
],
"offsets": [
[
91,
96
]
],
"normalized": []
},
{
"id": "split_0_train_2820_entity",
"type": "progene_text",
"text": [
"CD44"
],
"offsets": [
[
101,
105
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1842 | split_0_train_1842 | [
{
"id": "split_0_train_1842_passage",
"type": "progene_text",
"text": [
"Specific RHAMM variants of 85 - and 58 - kDa size were shown to bind avidly to HA following CPC precipitations ."
],
"offsets": [
[
0,
112
]
]
}
]
| [
{
"id": "split_0_train_2821_entity",
"type": "progene_text",
"text": [
"RHAMM"
],
"offsets": [
[
9,
14
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1843 | split_0_train_1843 | [
{
"id": "split_0_train_1843_passage",
"type": "progene_text",
"text": [
"RHAMM soluble peptide inhibited glioma cell line proliferation in a dose - dependent fashion ."
],
"offsets": [
[
0,
94
]
]
}
]
| [
{
"id": "split_0_train_2822_entity",
"type": "progene_text",
"text": [
"RHAMM"
],
"offsets": [
[
0,
5
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1844 | split_0_train_1844 | [
{
"id": "split_0_train_1844_passage",
"type": "progene_text",
"text": [
"Finally , while anti - CD44 antibodies did not inhibit the migration of human glioma cells , soluble peptides directed at the HA - binding domain of RHAMM inhibited glioma migration both on and off an HA - based ECM ."
],
"offsets": [
[
0,
217
]
]
}
]
| [
{
"id": "split_0_train_2823_entity",
"type": "progene_text",
"text": [
"CD44"
],
"offsets": [
[
23,
27
]
],
"normalized": []
},
{
"id": "split_0_train_2824_entity",
"type": "progene_text",
"text": [
"RHAMM"
],
"offsets": [
[
149,
154
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1845 | split_0_train_1845 | [
{
"id": "split_0_train_1845_passage",
"type": "progene_text",
"text": [
"These data support the notion that HA-receptors contribute to brain tumor adhesion , proliferation , and migration , biological features which must be better understood before more effective treatment strategies for these tumors can be found ."
],
"offsets": [
[
0,
243
]
]
}
]
| [
{
"id": "split_0_train_2825_entity",
"type": "progene_text",
"text": [
"HA-receptors"
],
"offsets": [
[
35,
47
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1846 | split_0_train_1846 | [
{
"id": "split_0_train_1846_passage",
"type": "progene_text",
"text": [
"Physical principles in therapeutic apheresis ."
],
"offsets": [
[
0,
46
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1847 | split_0_train_1847 | [
{
"id": "split_0_train_1847_passage",
"type": "progene_text",
"text": [
"Physical modality could have some impact on new apheresis technologies because it is nonbiologic and controllable for its operating conditions ."
],
"offsets": [
[
0,
144
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1848 | split_0_train_1848 | [
{
"id": "split_0_train_1848_passage",
"type": "progene_text",
"text": [
"In this article , the application of electromagnetic force and light scattering force to bioseparation and biostimulation was explored ."
],
"offsets": [
[
0,
136
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1849 | split_0_train_1849 | [
{
"id": "split_0_train_1849_passage",
"type": "progene_text",
"text": [
"MUC4 expression is increased in dysplastic cervical disorders ."
],
"offsets": [
[
0,
63
]
]
}
]
| [
{
"id": "split_0_train_2826_entity",
"type": "progene_text",
"text": [
"MUC4"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1850 | split_0_train_1850 | [
{
"id": "split_0_train_1850_passage",
"type": "progene_text",
"text": [
"The female uterine cervix has 2 characteristic populations of epithelial cells : the endocervix is composed by mucus - secreting cells that express several mucin genes , and the exocervix has a typical stratified squamous epithelium and does not express secreted mucins ."
],
"offsets": [
[
0,
271
]
]
}
]
| [
{
"id": "split_0_train_2827_entity",
"type": "progene_text",
"text": [
"mucin"
],
"offsets": [
[
156,
161
]
],
"normalized": []
},
{
"id": "split_0_train_2828_entity",
"type": "progene_text",
"text": [
"mucins"
],
"offsets": [
[
263,
269
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1851 | split_0_train_1851 | [
{
"id": "split_0_train_1851_passage",
"type": "progene_text",
"text": [
"Among human mucin genes , the MUC4 sequence has a transmembrane domain , and its molecular structure suggests that it has a protective role and also may be implicated in intracellular signalling ."
],
"offsets": [
[
0,
196
]
]
}
]
| [
{
"id": "split_0_train_2829_entity",
"type": "progene_text",
"text": [
"mucin"
],
"offsets": [
[
12,
17
]
],
"normalized": []
},
{
"id": "split_0_train_2830_entity",
"type": "progene_text",
"text": [
"MUC4"
],
"offsets": [
[
30,
34
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1852 | split_0_train_1852 | [
{
"id": "split_0_train_1852_passage",
"type": "progene_text",
"text": [
"The aim of this study is to analyze whether changes in the expression of MUC4 can be detected associated with the squamous dysplastic transformation of exocervical epithelium ."
],
"offsets": [
[
0,
176
]
]
}
]
| [
{
"id": "split_0_train_2831_entity",
"type": "progene_text",
"text": [
"MUC4"
],
"offsets": [
[
73,
77
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1853 | split_0_train_1853 | [
{
"id": "split_0_train_1853_passage",
"type": "progene_text",
"text": [
"MUC4 expression has been analyzed by immunohistochemistry , Western blotting , and in situ hybridization ."
],
"offsets": [
[
0,
106
]
]
}
]
| [
{
"id": "split_0_train_2832_entity",
"type": "progene_text",
"text": [
"MUC4"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1854 | split_0_train_1854 | [
{
"id": "split_0_train_1854_passage",
"type": "progene_text",
"text": [
"Using immunohistochemical techniques , MUC4 is found in normal endocervix ( n = 11 ) and is absent or only focally detected in the normal stratified cervical epithelium ( n = 18 ) ."
],
"offsets": [
[
0,
181
]
]
}
]
| [
{
"id": "split_0_train_2833_entity",
"type": "progene_text",
"text": [
"MUC4"
],
"offsets": [
[
39,
43
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1855 | split_0_train_1855 | [
{
"id": "split_0_train_1855_passage",
"type": "progene_text",
"text": [
"In samples from squamous metaplasia ( n = 9 ) , MUC4 is variably expressed ( 10 % to 50 % positive cells ) , whereas MUC4 is strongly detected in dysplastic cervical epithelia ."
],
"offsets": [
[
0,
177
]
]
}
]
| [
{
"id": "split_0_train_2834_entity",
"type": "progene_text",
"text": [
"MUC4"
],
"offsets": [
[
48,
52
]
],
"normalized": []
},
{
"id": "split_0_train_2835_entity",
"type": "progene_text",
"text": [
"MUC4"
],
"offsets": [
[
117,
121
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1856 | split_0_train_1856 | [
{
"id": "split_0_train_1856_passage",
"type": "progene_text",
"text": [
"The greatest number of positive cells is found in samples with moderate and severe dysplasia in which MUC4 is detected in 100 % of the analyzed samples ( n = 16 ) ."
],
"offsets": [
[
0,
164
]
]
}
]
| [
{
"id": "split_0_train_2836_entity",
"type": "progene_text",
"text": [
"MUC4"
],
"offsets": [
[
102,
106
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1857 | split_0_train_1857 | [
{
"id": "split_0_train_1857_passage",
"type": "progene_text",
"text": [
"These results have been confirmed by Western blotting and by detection of MUC4 transcripts using in situ hybridization ."
],
"offsets": [
[
0,
120
]
]
}
]
| [
{
"id": "split_0_train_2837_entity",
"type": "progene_text",
"text": [
"MUC4"
],
"offsets": [
[
74,
78
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1858 | split_0_train_1858 | [
{
"id": "split_0_train_1858_passage",
"type": "progene_text",
"text": [
"The present data suggest that MUC4 is activated during the process of squamous dysplastic transformation and may be used as a marker for this pathologic process ."
],
"offsets": [
[
0,
162
]
]
}
]
| [
{
"id": "split_0_train_2838_entity",
"type": "progene_text",
"text": [
"MUC4"
],
"offsets": [
[
30,
34
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1859 | split_0_train_1859 | [
{
"id": "split_0_train_1859_passage",
"type": "progene_text",
"text": [
"Hepatocyte nuclear factor 1alpha controls the expression of terminal complement genes ."
],
"offsets": [
[
0,
87
]
]
}
]
| [
{
"id": "split_0_train_2839_entity",
"type": "progene_text",
"text": [
"Hepatocyte nuclear factor 1alpha"
],
"offsets": [
[
0,
32
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1860 | split_0_train_1860 | [
{
"id": "split_0_train_1860_passage",
"type": "progene_text",
"text": [
"The terminal components of the complement system contribute to host defense by forming the multiprotein membrane attack complex ( MAC ) which is responsible for cell lysis and several noncytotoxic effects ."
],
"offsets": [
[
0,
206
]
]
}
]
| [
{
"id": "split_0_train_2840_entity",
"type": "progene_text",
"text": [
"membrane attack complex"
],
"offsets": [
[
104,
127
]
],
"normalized": []
},
{
"id": "split_0_train_2841_entity",
"type": "progene_text",
"text": [
"MAC"
],
"offsets": [
[
130,
133
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1861 | split_0_train_1861 | [
{
"id": "split_0_train_1861_passage",
"type": "progene_text",
"text": [
"Most of the complement proteins are synthesized in the liver , but the mechanisms controlling their tissue - specific expression have not been elucidated ."
],
"offsets": [
[
0,
155
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1862 | split_0_train_1862 | [
{
"id": "split_0_train_1862_passage",
"type": "progene_text",
"text": [
"In this study we show that mice lacking the hepatic transcription factor hepatocyte nuclear factor 1alpha ( HNF1alpha ) fail to transcribe C5 and C8A complement genes ."
],
"offsets": [
[
0,
168
]
]
}
]
| [
{
"id": "split_0_train_2842_entity",
"type": "progene_text",
"text": [
"transcription factor"
],
"offsets": [
[
52,
72
]
],
"normalized": []
},
{
"id": "split_0_train_2843_entity",
"type": "progene_text",
"text": [
"hepatocyte nuclear factor 1alpha"
],
"offsets": [
[
73,
105
]
],
"normalized": []
},
{
"id": "split_0_train_2844_entity",
"type": "progene_text",
"text": [
"HNF1alpha"
],
"offsets": [
[
108,
117
]
],
"normalized": []
},
{
"id": "split_0_train_2845_entity",
"type": "progene_text",
"text": [
"C5"
],
"offsets": [
[
139,
141
]
],
"normalized": []
},
{
"id": "split_0_train_2846_entity",
"type": "progene_text",
"text": [
"C8A"
],
"offsets": [
[
146,
149
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1863 | split_0_train_1863 | [
{
"id": "split_0_train_1863_passage",
"type": "progene_text",
"text": [
"In addition , mRNAs encoding for several other terminal complement components or subunits are expressed at lower levels , including C8beta , C8gamma , and C9 ."
],
"offsets": [
[
0,
159
]
]
}
]
| [
{
"id": "split_0_train_2847_entity",
"type": "progene_text",
"text": [
"complement components"
],
"offsets": [
[
56,
77
]
],
"normalized": []
},
{
"id": "split_0_train_2848_entity",
"type": "progene_text",
"text": [
"C8beta"
],
"offsets": [
[
132,
138
]
],
"normalized": []
},
{
"id": "split_0_train_2849_entity",
"type": "progene_text",
"text": [
"C8gamma"
],
"offsets": [
[
141,
148
]
],
"normalized": []
},
{
"id": "split_0_train_2850_entity",
"type": "progene_text",
"text": [
"C9"
],
"offsets": [
[
155,
157
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1864 | split_0_train_1864 | [
{
"id": "split_0_train_1864_passage",
"type": "progene_text",
"text": [
"We next used a reconstitution assay involving human sera with selective complement deficiencies to assess mouse complement activity ."
],
"offsets": [
[
0,
133
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1865 | split_0_train_1865 | [
{
"id": "split_0_train_1865_passage",
"type": "progene_text",
"text": [
"Sera from HNF1alpha - deficient mice showed negligible hemolytic activity of both C5 and C8alpha - gamma subunits ."
],
"offsets": [
[
0,
115
]
]
}
]
| [
{
"id": "split_0_train_2851_entity",
"type": "progene_text",
"text": [
"HNF1alpha"
],
"offsets": [
[
10,
19
]
],
"normalized": []
},
{
"id": "split_0_train_2852_entity",
"type": "progene_text",
"text": [
"C5"
],
"offsets": [
[
82,
84
]
],
"normalized": []
},
{
"id": "split_0_train_2853_entity",
"type": "progene_text",
"text": [
"C8alpha - gamma"
],
"offsets": [
[
89,
104
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1866 | split_0_train_1866 | [
{
"id": "split_0_train_1866_passage",
"type": "progene_text",
"text": [
"The activity of C8beta was severely affected despite only a 50 % reduction in C8beta mRNA levels in the liver ."
],
"offsets": [
[
0,
111
]
]
}
]
| [
{
"id": "split_0_train_2854_entity",
"type": "progene_text",
"text": [
"C8beta"
],
"offsets": [
[
16,
22
]
],
"normalized": []
},
{
"id": "split_0_train_2855_entity",
"type": "progene_text",
"text": [
"C8beta"
],
"offsets": [
[
78,
84
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1867 | split_0_train_1867 | [
{
"id": "split_0_train_1867_passage",
"type": "progene_text",
"text": [
"This is reminiscent of C8alpha - gamma - deficient patients who accumulate extremely low levels of the C8beta subunit ."
],
"offsets": [
[
0,
119
]
]
}
]
| [
{
"id": "split_0_train_2856_entity",
"type": "progene_text",
"text": [
"C8alpha - gamma"
],
"offsets": [
[
23,
38
]
],
"normalized": []
},
{
"id": "split_0_train_2857_entity",
"type": "progene_text",
"text": [
"C8beta"
],
"offsets": [
[
103,
109
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1868 | split_0_train_1868 | [
{
"id": "split_0_train_1868_passage",
"type": "progene_text",
"text": [
"Our results demonstrate that HNF1alpha plays a key role in the expression of C5 and C8A genes , two terminal complement component genes that are essential for the assembly of MAC as a result of complement activation ."
],
"offsets": [
[
0,
217
]
]
}
]
| [
{
"id": "split_0_train_2858_entity",
"type": "progene_text",
"text": [
"HNF1alpha"
],
"offsets": [
[
29,
38
]
],
"normalized": []
},
{
"id": "split_0_train_2859_entity",
"type": "progene_text",
"text": [
"C5"
],
"offsets": [
[
77,
79
]
],
"normalized": []
},
{
"id": "split_0_train_2860_entity",
"type": "progene_text",
"text": [
"C8A"
],
"offsets": [
[
84,
87
]
],
"normalized": []
},
{
"id": "split_0_train_2861_entity",
"type": "progene_text",
"text": [
"MAC"
],
"offsets": [
[
175,
178
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1869 | split_0_train_1869 | [
{
"id": "split_0_train_1869_passage",
"type": "progene_text",
"text": [
"Cloning , characterisation and crystallisation of a diadenosine 5',5\"'-P(1),P(4)-tetraphosphate pyrophosphohydrolase from Caenorhabditis elegans ."
],
"offsets": [
[
0,
146
]
]
}
]
| [
{
"id": "split_0_train_2862_entity",
"type": "progene_text",
"text": [
"diadenosine 5',5\"'-P(1),P(4)-tetraphosphate pyrophosphohydrolase"
],
"offsets": [
[
52,
116
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1870 | split_0_train_1870 | [
{
"id": "split_0_train_1870_passage",
"type": "progene_text",
"text": [
"Asymmetrically cleaving diadenosine 5',5\"'-P(1),P(4)-tetraphosphate ( Ap4A ) hydrolase activity has been detected in extracts of adult Caenorhabditis elegans and the corresponding cDNA amplified and expressed in Escherichia coli ."
],
"offsets": [
[
0,
230
]
]
}
]
| [
{
"id": "split_0_train_2863_entity",
"type": "progene_text",
"text": [
"diadenosine 5',5\"'-P(1),P(4)-tetraphosphate ( Ap4A ) hydrolase"
],
"offsets": [
[
24,
86
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1871 | split_0_train_1871 | [
{
"id": "split_0_train_1871_passage",
"type": "progene_text",
"text": [
"As expected , sequence analysis shows the enzyme to be a member of the Nudix hydrolase family ."
],
"offsets": [
[
0,
95
]
]
}
]
| [
{
"id": "split_0_train_2864_entity",
"type": "progene_text",
"text": [
"Nudix hydrolase family"
],
"offsets": [
[
71,
93
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1872 | split_0_train_1872 | [
{
"id": "split_0_train_1872_passage",
"type": "progene_text",
"text": [
"The purified recombinant enzyme behaves as a typical animal Ap4A hydrolase ."
],
"offsets": [
[
0,
76
]
]
}
]
| [
{
"id": "split_0_train_2865_entity",
"type": "progene_text",
"text": [
"Ap4A hydrolase"
],
"offsets": [
[
60,
74
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1873 | split_0_train_1873 | [
{
"id": "split_0_train_1873_passage",
"type": "progene_text",
"text": [
"It hydrolyses Ap4A with a K(m) of 7 microM and k(cat) of 27 s(-1) producing AMP and ATP as products ."
],
"offsets": [
[
0,
101
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1874 | split_0_train_1874 | [
{
"id": "split_0_train_1874_passage",
"type": "progene_text",
"text": [
"It is also active towards other adenosine and diadenosine polyphosphates with four or more phosphate groups , but not diadenosine triphosphate , always generating ATP as one of the products ."
],
"offsets": [
[
0,
191
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1875 | split_0_train_1875 | [
{
"id": "split_0_train_1875_passage",
"type": "progene_text",
"text": [
"It is inhibited non - competitively by fluoride ( K(i) = 25 microM ) and competitively by adenosine 5'-tetraphosphate with Ap4A as substrate ( K(i) = 10 nM ) ."
],
"offsets": [
[
0,
159
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1876 | split_0_train_1876 | [
{
"id": "split_0_train_1876_passage",
"type": "progene_text",
"text": [
"Crystals of diffraction quality with the morphology of rectangular plates were readily obtained and preliminary data collected ."
],
"offsets": [
[
0,
128
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1877 | split_0_train_1877 | [
{
"id": "split_0_train_1877_passage",
"type": "progene_text",
"text": [
"These crystals diffract to a minimum d - spacing of 2 A and belong to either space group C222 or C222(1) ."
],
"offsets": [
[
0,
106
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1878 | split_0_train_1878 | [
{
"id": "split_0_train_1878_passage",
"type": "progene_text",
"text": [
"Phylogenetic analysis of known and putative Ap4A hydrolases of the Nudix family suggests that they fall into two groups comprising plant and Proteobacterial enzymes on the one hand and animal and archaeal enzymes on the other ."
],
"offsets": [
[
0,
227
]
]
}
]
| [
{
"id": "split_0_train_2866_entity",
"type": "progene_text",
"text": [
"Ap4A hydrolases"
],
"offsets": [
[
44,
59
]
],
"normalized": []
},
{
"id": "split_0_train_2867_entity",
"type": "progene_text",
"text": [
"Nudix family"
],
"offsets": [
[
67,
79
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1879 | split_0_train_1879 | [
{
"id": "split_0_train_1879_passage",
"type": "progene_text",
"text": [
"Complete structural determination of the C. elegans Ap4A hydrolase will help determine the basis of this grouping ."
],
"offsets": [
[
0,
115
]
]
}
]
| [
{
"id": "split_0_train_2868_entity",
"type": "progene_text",
"text": [
"Ap4A hydrolase"
],
"offsets": [
[
52,
66
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1880 | split_0_train_1880 | [
{
"id": "split_0_train_1880_passage",
"type": "progene_text",
"text": [
"Transcription factors NF-Y and Sp1 are important determinants of the promoter activity of the bovine and human neuronal nicotinic receptor beta 4 subunit genes ."
],
"offsets": [
[
0,
161
]
]
}
]
| [
{
"id": "split_0_train_2869_entity",
"type": "progene_text",
"text": [
"Transcription factors"
],
"offsets": [
[
0,
21
]
],
"normalized": []
},
{
"id": "split_0_train_2870_entity",
"type": "progene_text",
"text": [
"NF-Y"
],
"offsets": [
[
22,
26
]
],
"normalized": []
},
{
"id": "split_0_train_2871_entity",
"type": "progene_text",
"text": [
"Sp1"
],
"offsets": [
[
31,
34
]
],
"normalized": []
},
{
"id": "split_0_train_2872_entity",
"type": "progene_text",
"text": [
"nicotinic receptor beta 4"
],
"offsets": [
[
120,
145
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1881 | split_0_train_1881 | [
{
"id": "split_0_train_1881_passage",
"type": "progene_text",
"text": [
"The beta4 subunit is a component of the neuronal nicotinic acetylcholine receptors which control catecholamine secretion in bovine adrenomedullary chromaffin cells ."
],
"offsets": [
[
0,
165
]
]
}
]
| [
{
"id": "split_0_train_2873_entity",
"type": "progene_text",
"text": [
"nicotinic acetylcholine receptors"
],
"offsets": [
[
49,
82
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1882 | split_0_train_1882 | [
{
"id": "split_0_train_1882_passage",
"type": "progene_text",
"text": [
"The promoter of the gene coding for this subunit was characterized ."
],
"offsets": [
[
0,
68
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1883 | split_0_train_1883 | [
{
"id": "split_0_train_1883_passage",
"type": "progene_text",
"text": [
"A proximal region ( from minus sign99 to minus sign64 ) was responsible for the transcriptional activity observed in chromaffin , C2C12 , and COS cells ."
],
"offsets": [
[
0,
153
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1884 | split_0_train_1884 | [
{
"id": "split_0_train_1884_passage",
"type": "progene_text",
"text": [
"Within this region two cis - acting elements that bind transcription factors Sp1 and NF-Y were identified ."
],
"offsets": [
[
0,
107
]
]
}
]
| [
{
"id": "split_0_train_2874_entity",
"type": "progene_text",
"text": [
"transcription factors"
],
"offsets": [
[
55,
76
]
],
"normalized": []
},
{
"id": "split_0_train_2875_entity",
"type": "progene_text",
"text": [
"Sp1"
],
"offsets": [
[
77,
80
]
],
"normalized": []
},
{
"id": "split_0_train_2876_entity",
"type": "progene_text",
"text": [
"NF-Y"
],
"offsets": [
[
85,
89
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1885 | split_0_train_1885 | [
{
"id": "split_0_train_1885_passage",
"type": "progene_text",
"text": [
"Mutagenesis of the two elements indicated that they cooperate for the basal transcription activity of the promoter ."
],
"offsets": [
[
0,
116
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1886 | split_0_train_1886 | [
{
"id": "split_0_train_1886_passage",
"type": "progene_text",
"text": [
"The human beta4 promoter , that was also characterized , shared structural and functional homologies with the bovine promoter ."
],
"offsets": [
[
0,
127
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1887 | split_0_train_1887 | [
{
"id": "split_0_train_1887_passage",
"type": "progene_text",
"text": [
"Thus , two adjacent binding elements for Sp1 and NF-Y were detected ."
],
"offsets": [
[
0,
69
]
]
}
]
| [
{
"id": "split_0_train_2877_entity",
"type": "progene_text",
"text": [
"Sp1"
],
"offsets": [
[
41,
44
]
],
"normalized": []
},
{
"id": "split_0_train_2878_entity",
"type": "progene_text",
"text": [
"NF-Y"
],
"offsets": [
[
49,
53
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1888 | split_0_train_1888 | [
{
"id": "split_0_train_1888_passage",
"type": "progene_text",
"text": [
"Whereas the Sp1 site was an important determinant of the promoter activity , the NF-Y site may have cell - specific effects ."
],
"offsets": [
[
0,
125
]
]
}
]
| [
{
"id": "split_0_train_2879_entity",
"type": "progene_text",
"text": [
"Sp1"
],
"offsets": [
[
12,
15
]
],
"normalized": []
},
{
"id": "split_0_train_2880_entity",
"type": "progene_text",
"text": [
"NF-Y"
],
"offsets": [
[
81,
85
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1889 | split_0_train_1889 | [
{
"id": "split_0_train_1889_passage",
"type": "progene_text",
"text": [
"Given that these promoters showed no structural or functional homology with the previously characterized rat beta4 subunit promoter ( Bigger , C. B. , Casanova , E. A. , and Gardner , P. D. ( 1996 ) J. Biol. Chem. 271 , 32842 - - 32848 ) except for the involvement of an Sp1 binding element , we propose that constitutive expression of the beta4 subunit gene in these three close species may be controlled by the general transcription factor Sp1 ."
],
"offsets": [
[
0,
447
]
]
}
]
| [
{
"id": "split_0_train_2881_entity",
"type": "progene_text",
"text": [
"Sp1"
],
"offsets": [
[
271,
274
]
],
"normalized": []
},
{
"id": "split_0_train_2882_entity",
"type": "progene_text",
"text": [
"transcription factor"
],
"offsets": [
[
421,
441
]
],
"normalized": []
},
{
"id": "split_0_train_2883_entity",
"type": "progene_text",
"text": [
"Sp1"
],
"offsets": [
[
442,
445
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1890 | split_0_train_1890 | [
{
"id": "split_0_train_1890_passage",
"type": "progene_text",
"text": [
"Nevertheless , other components could determine species - specific beta4 subunit expression ."
],
"offsets": [
[
0,
93
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1891 | split_0_train_1891 | [
{
"id": "split_0_train_1891_passage",
"type": "progene_text",
"text": [
"Signal transduction system for interleukin-6 synthesis stimulated by lipopolysaccharide in human osteoblasts ."
],
"offsets": [
[
0,
110
]
]
}
]
| [
{
"id": "split_0_train_2884_entity",
"type": "progene_text",
"text": [
"interleukin-6"
],
"offsets": [
[
31,
44
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1892 | split_0_train_1892 | [
{
"id": "split_0_train_1892_passage",
"type": "progene_text",
"text": [
"Lipopolysaccharide ( LPS ) is a bacterial cell component that plays multifunctional roles in inflammatory reactions , and one of the roles is as a powerful stimulator of bone resorption ."
],
"offsets": [
[
0,
187
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1893 | split_0_train_1893 | [
{
"id": "split_0_train_1893_passage",
"type": "progene_text",
"text": [
"LPS stimulated bone resorption via CD14 in mouse calvaria and was reported to function as a receptor for bacterial LPS complexed with serum proteins ."
],
"offsets": [
[
0,
150
]
]
}
]
| [
{
"id": "split_0_train_2885_entity",
"type": "progene_text",
"text": [
"CD14"
],
"offsets": [
[
35,
39
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1894 | split_0_train_1894 | [
{
"id": "split_0_train_1894_passage",
"type": "progene_text",
"text": [
"Interleukin-6 ( IL-6 ) is capable of stimulating the differentiation of osteoclasts from their hematopoietic precursors , and LPS elevates IL-6 synthesis in human osteoblastic cells ."
],
"offsets": [
[
0,
183
]
]
}
]
| [
{
"id": "split_0_train_2886_entity",
"type": "progene_text",
"text": [
"Interleukin-6"
],
"offsets": [
[
0,
13
]
],
"normalized": []
},
{
"id": "split_0_train_2887_entity",
"type": "progene_text",
"text": [
"IL-6"
],
"offsets": [
[
16,
20
]
],
"normalized": []
},
{
"id": "split_0_train_2888_entity",
"type": "progene_text",
"text": [
"IL-6"
],
"offsets": [
[
139,
143
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1895 | split_0_train_1895 | [
{
"id": "split_0_train_1895_passage",
"type": "progene_text",
"text": [
"However , the signaling pathway of LPS - induced IL-6 synthesis in osteoblasts is unknown ."
],
"offsets": [
[
0,
91
]
]
}
]
| [
{
"id": "split_0_train_2889_entity",
"type": "progene_text",
"text": [
"IL-6"
],
"offsets": [
[
49,
53
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1896 | split_0_train_1896 | [
{
"id": "split_0_train_1896_passage",
"type": "progene_text",
"text": [
"In the present study , we could detect the existence of CD14 in human osteoblastic cells by RT - PCR analysis and show that LPS increased IL-6 mRNA and synthesis via CD14 in human osteoblastic cells ."
],
"offsets": [
[
0,
200
]
]
}
]
| [
{
"id": "split_0_train_2890_entity",
"type": "progene_text",
"text": [
"CD14"
],
"offsets": [
[
56,
60
]
],
"normalized": []
},
{
"id": "split_0_train_2891_entity",
"type": "progene_text",
"text": [
"IL-6"
],
"offsets": [
[
138,
142
]
],
"normalized": []
},
{
"id": "split_0_train_2892_entity",
"type": "progene_text",
"text": [
"CD14"
],
"offsets": [
[
166,
170
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1897 | split_0_train_1897 | [
{
"id": "split_0_train_1897_passage",
"type": "progene_text",
"text": [
"In human osteoblasts ( SaM-1 cells ) treated with 10 microg / ml LPS , increases in IL-6 mRNA and synthesis were inhibited by anti - CD14 antibody ( MEM-18 ) , PD98059 ( an inhibitor of classic mitogen - activated protein kinase [ MAPK ] ) , or SB203580 ( an inhibitor of p38 MAPK ) but were not inhibited by H-89 ( an inhibitor of protein kinase A [ PKA ] ) and calphostin C ( an inhibitor of protein kinase C [ PKC ] ) ."
],
"offsets": [
[
0,
422
]
]
}
]
| [
{
"id": "split_0_train_2893_entity",
"type": "progene_text",
"text": [
"IL-6"
],
"offsets": [
[
84,
88
]
],
"normalized": []
},
{
"id": "split_0_train_2894_entity",
"type": "progene_text",
"text": [
"CD14"
],
"offsets": [
[
133,
137
]
],
"normalized": []
},
{
"id": "split_0_train_2895_entity",
"type": "progene_text",
"text": [
"mitogen - activated protein kinase"
],
"offsets": [
[
194,
228
]
],
"normalized": []
},
{
"id": "split_0_train_2896_entity",
"type": "progene_text",
"text": [
"MAPK"
],
"offsets": [
[
231,
235
]
],
"normalized": []
},
{
"id": "split_0_train_2897_entity",
"type": "progene_text",
"text": [
"p38 MAPK"
],
"offsets": [
[
272,
280
]
],
"normalized": []
},
{
"id": "split_0_train_2898_entity",
"type": "progene_text",
"text": [
"protein kinase A"
],
"offsets": [
[
332,
348
]
],
"normalized": []
},
{
"id": "split_0_train_2899_entity",
"type": "progene_text",
"text": [
"PKA"
],
"offsets": [
[
351,
354
]
],
"normalized": []
},
{
"id": "split_0_train_2900_entity",
"type": "progene_text",
"text": [
"protein kinase C"
],
"offsets": [
[
394,
410
]
],
"normalized": []
},
{
"id": "split_0_train_2901_entity",
"type": "progene_text",
"text": [
"PKC"
],
"offsets": [
[
413,
416
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1898 | split_0_train_1898 | [
{
"id": "split_0_train_1898_passage",
"type": "progene_text",
"text": [
"Furthermore , LPS - induced IL-6 synthesis was inhibited by curcumin ( an inhibitor of activating protein-1 [ AP-1 ] ) but not by pyrrolidine dithiocarbamate ( PDTC ) ( an inhibitor of nuclear factor kappa B [ NF-kappaB ] ) ."
],
"offsets": [
[
0,
225
]
]
}
]
| [
{
"id": "split_0_train_2902_entity",
"type": "progene_text",
"text": [
"IL-6"
],
"offsets": [
[
28,
32
]
],
"normalized": []
},
{
"id": "split_0_train_2903_entity",
"type": "progene_text",
"text": [
"activating protein-1"
],
"offsets": [
[
87,
107
]
],
"normalized": []
},
{
"id": "split_0_train_2904_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
110,
114
]
],
"normalized": []
},
{
"id": "split_0_train_2905_entity",
"type": "progene_text",
"text": [
"nuclear factor kappa B"
],
"offsets": [
[
185,
207
]
],
"normalized": []
},
{
"id": "split_0_train_2906_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
210,
219
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1899 | split_0_train_1899 | [
{
"id": "split_0_train_1899_passage",
"type": "progene_text",
"text": [
"The findings of the present study suggest that the LPS receptor CD14 , existent in human osteoblastic cells , and IL-6 synthesis in response to LPS probably occur via CD14 , p38 MAPK , and MAP kinase / extracellular - regulated kinase kinase ( MEK ) , leading to the transcriptional activation of AP-1 in human osteoblastic cells ."
],
"offsets": [
[
0,
331
]
]
}
]
| [
{
"id": "split_0_train_2907_entity",
"type": "progene_text",
"text": [
"CD14"
],
"offsets": [
[
64,
68
]
],
"normalized": []
},
{
"id": "split_0_train_2908_entity",
"type": "progene_text",
"text": [
"IL-6"
],
"offsets": [
[
114,
118
]
],
"normalized": []
},
{
"id": "split_0_train_2909_entity",
"type": "progene_text",
"text": [
"CD14"
],
"offsets": [
[
167,
171
]
],
"normalized": []
},
{
"id": "split_0_train_2910_entity",
"type": "progene_text",
"text": [
"p38 MAPK"
],
"offsets": [
[
174,
182
]
],
"normalized": []
},
{
"id": "split_0_train_2911_entity",
"type": "progene_text",
"text": [
"MAP kinase / extracellular - regulated kinase kinase"
],
"offsets": [
[
189,
241
]
],
"normalized": []
},
{
"id": "split_0_train_2912_entity",
"type": "progene_text",
"text": [
"MEK"
],
"offsets": [
[
244,
247
]
],
"normalized": []
},
{
"id": "split_0_train_2913_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
297,
301
]
],
"normalized": []
}
]
| []
| []
| []
|
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