id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
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|---|---|---|---|---|---|---|
split_0_train_1600 | split_0_train_1600 | [
{
"id": "split_0_train_1600_passage",
"type": "progene_text",
"text": [
"This Asf1 / Hir silencing pathway functionally overlaps with CAF-I activity ."
],
"offsets": [
[
0,
77
]
]
}
]
| [
{
"id": "split_0_train_2531_entity",
"type": "progene_text",
"text": [
"Asf1"
],
"offsets": [
[
5,
9
]
],
"normalized": []
},
{
"id": "split_0_train_2532_entity",
"type": "progene_text",
"text": [
"Hir"
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"offsets": [
[
12,
15
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"normalized": []
},
{
"id": "split_0_train_2533_entity",
"type": "progene_text",
"text": [
"CAF-I"
],
"offsets": [
[
61,
66
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1601 | split_0_train_1601 | [
{
"id": "split_0_train_1601_passage",
"type": "progene_text",
"text": [
"Direct interaction of the Rab3 effector RIM with Ca2+ channels , SNAP-25 , and synaptotagmin ."
],
"offsets": [
[
0,
94
]
]
}
]
| [
{
"id": "split_0_train_2534_entity",
"type": "progene_text",
"text": [
"Rab3"
],
"offsets": [
[
26,
30
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{
"id": "split_0_train_2535_entity",
"type": "progene_text",
"text": [
"RIM"
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[
40,
43
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"normalized": []
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{
"id": "split_0_train_2536_entity",
"type": "progene_text",
"text": [
"Ca2+ channels"
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[
49,
62
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"normalized": []
},
{
"id": "split_0_train_2537_entity",
"type": "progene_text",
"text": [
"SNAP-25"
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"offsets": [
[
65,
72
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],
"normalized": []
},
{
"id": "split_0_train_2538_entity",
"type": "progene_text",
"text": [
"synaptotagmin"
],
"offsets": [
[
79,
92
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1602 | split_0_train_1602 | [
{
"id": "split_0_train_1602_passage",
"type": "progene_text",
"text": [
"To define the role of the Rab3 - interacting molecule RIM in exocytosis we searched for additional binding partners of the protein ."
],
"offsets": [
[
0,
132
]
]
}
]
| [
{
"id": "split_0_train_2539_entity",
"type": "progene_text",
"text": [
"Rab3 - interacting molecule"
],
"offsets": [
[
26,
53
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],
"normalized": []
},
{
"id": "split_0_train_2540_entity",
"type": "progene_text",
"text": [
"RIM"
],
"offsets": [
[
54,
57
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1603 | split_0_train_1603 | [
{
"id": "split_0_train_1603_passage",
"type": "progene_text",
"text": [
"We found that the two C(2) domains of RIM display properties analogous to those of the C(2) B domain of synaptotagmin-I ."
],
"offsets": [
[
0,
121
]
]
}
]
| [
{
"id": "split_0_train_2541_entity",
"type": "progene_text",
"text": [
"RIM"
],
"offsets": [
[
38,
41
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],
"normalized": []
},
{
"id": "split_0_train_2542_entity",
"type": "progene_text",
"text": [
"synaptotagmin-I"
],
"offsets": [
[
104,
119
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1604 | split_0_train_1604 | [
{
"id": "split_0_train_1604_passage",
"type": "progene_text",
"text": [
"Thus , RIM - C(2) A and RIM - C(2) B bind in a Ca(2+) - independent manner to alpha1B , the pore - forming subunit of N-type Ca(2+) channels ( EC ( 50 ) = approximately 20 nm ) ."
],
"offsets": [
[
0,
178
]
]
}
]
| [
{
"id": "split_0_train_2543_entity",
"type": "progene_text",
"text": [
"RIM"
],
"offsets": [
[
7,
10
]
],
"normalized": []
},
{
"id": "split_0_train_2544_entity",
"type": "progene_text",
"text": [
"RIM"
],
"offsets": [
[
24,
27
]
],
"normalized": []
},
{
"id": "split_0_train_2545_entity",
"type": "progene_text",
"text": [
"alpha1B"
],
"offsets": [
[
78,
85
]
],
"normalized": []
},
{
"id": "split_0_train_2546_entity",
"type": "progene_text",
"text": [
"N-type Ca(2+) channels"
],
"offsets": [
[
118,
140
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1605 | split_0_train_1605 | [
{
"id": "split_0_train_1605_passage",
"type": "progene_text",
"text": [
"They also weakly interact with the alpha1C but not the alpha1D subunit of L-type Ca(2+) channels ."
],
"offsets": [
[
0,
98
]
]
}
]
| [
{
"id": "split_0_train_2547_entity",
"type": "progene_text",
"text": [
"alpha1C"
],
"offsets": [
[
35,
42
]
],
"normalized": []
},
{
"id": "split_0_train_2548_entity",
"type": "progene_text",
"text": [
"alpha1D"
],
"offsets": [
[
55,
62
]
],
"normalized": []
},
{
"id": "split_0_train_2549_entity",
"type": "progene_text",
"text": [
"L-type Ca(2+) channels"
],
"offsets": [
[
74,
96
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1606 | split_0_train_1606 | [
{
"id": "split_0_train_1606_passage",
"type": "progene_text",
"text": [
"In addition , the C(2) domains of RIM associate with SNAP-25 and synaptotagmin-I ."
],
"offsets": [
[
0,
82
]
]
}
]
| [
{
"id": "split_0_train_2550_entity",
"type": "progene_text",
"text": [
"SNAP-25"
],
"offsets": [
[
53,
60
]
],
"normalized": []
},
{
"id": "split_0_train_2551_entity",
"type": "progene_text",
"text": [
"synaptotagmin-I"
],
"offsets": [
[
65,
80
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1607 | split_0_train_1607 | [
{
"id": "split_0_train_1607_passage",
"type": "progene_text",
"text": [
"The binding affinities for these two proteins are 203 and 24 nm , respectively , for RIM - C(2) A and 224 and 16 nm for RIM - C(2)B ."
],
"offsets": [
[
0,
133
]
]
}
]
| [
{
"id": "split_0_train_2552_entity",
"type": "progene_text",
"text": [
"RIM"
],
"offsets": [
[
85,
88
]
],
"normalized": []
},
{
"id": "split_0_train_2553_entity",
"type": "progene_text",
"text": [
"RIM"
],
"offsets": [
[
120,
123
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1608 | split_0_train_1608 | [
{
"id": "split_0_train_1608_passage",
"type": "progene_text",
"text": [
"The interactions of the C(2) domains of RIM with SNAP-25 and synaptotagmin-I are modulated by Ca(2+) ."
],
"offsets": [
[
0,
102
]
]
}
]
| [
{
"id": "split_0_train_2554_entity",
"type": "progene_text",
"text": [
"RIM"
],
"offsets": [
[
40,
43
]
],
"normalized": []
},
{
"id": "split_0_train_2555_entity",
"type": "progene_text",
"text": [
"SNAP-25"
],
"offsets": [
[
49,
56
]
],
"normalized": []
},
{
"id": "split_0_train_2556_entity",
"type": "progene_text",
"text": [
"synaptotagmin-I"
],
"offsets": [
[
61,
76
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1609 | split_0_train_1609 | [
{
"id": "split_0_train_1609_passage",
"type": "progene_text",
"text": [
"Thus , in the presence of Ca(2+) ( EC(50) = approximately 75 microm ) the interaction with synaptotagmin-I is increased , whereas SNAP-25 binding is reduced ."
],
"offsets": [
[
0,
158
]
]
}
]
| [
{
"id": "split_0_train_2557_entity",
"type": "progene_text",
"text": [
"synaptotagmin-I"
],
"offsets": [
[
91,
106
]
],
"normalized": []
},
{
"id": "split_0_train_2558_entity",
"type": "progene_text",
"text": [
"SNAP-25"
],
"offsets": [
[
130,
137
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1610 | split_0_train_1610 | [
{
"id": "split_0_train_1610_passage",
"type": "progene_text",
"text": [
"Synaptotagmin-I binding is abolished by mutations in two positively charged amino acids in the C(2) domains of RIM and by the addition of inositol polyphosphates ."
],
"offsets": [
[
0,
163
]
]
}
]
| [
{
"id": "split_0_train_2559_entity",
"type": "progene_text",
"text": [
"Synaptotagmin-I"
],
"offsets": [
[
0,
15
]
],
"normalized": []
},
{
"id": "split_0_train_2560_entity",
"type": "progene_text",
"text": [
"RIM"
],
"offsets": [
[
111,
114
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1611 | split_0_train_1611 | [
{
"id": "split_0_train_1611_passage",
"type": "progene_text",
"text": [
"We propose that the Rab3 effector RIM is a scaffold protein that participates through its multiple binding partners in the docking and fusion of secretory vesicles at the release sites ."
],
"offsets": [
[
0,
186
]
]
}
]
| [
{
"id": "split_0_train_2561_entity",
"type": "progene_text",
"text": [
"Rab3"
],
"offsets": [
[
20,
24
]
],
"normalized": []
},
{
"id": "split_0_train_2562_entity",
"type": "progene_text",
"text": [
"RIM"
],
"offsets": [
[
34,
37
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1612 | split_0_train_1612 | [
{
"id": "split_0_train_1612_passage",
"type": "progene_text",
"text": [
"Specific inhibition of the rat ligand - gated ion channel P2X3 function via methoxyethoxy - modified phosphorothioated antisense oligonucleotides ."
],
"offsets": [
[
0,
147
]
]
}
]
| [
{
"id": "split_0_train_2563_entity",
"type": "progene_text",
"text": [
"ion channel"
],
"offsets": [
[
46,
57
]
],
"normalized": []
},
{
"id": "split_0_train_2564_entity",
"type": "progene_text",
"text": [
"P2X3"
],
"offsets": [
[
58,
62
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1613 | split_0_train_1613 | [
{
"id": "split_0_train_1613_passage",
"type": "progene_text",
"text": [
"P2X3 is one receptor of a family of seven ligand - gated ion channels responding to purines ."
],
"offsets": [
[
0,
93
]
]
}
]
| [
{
"id": "split_0_train_2565_entity",
"type": "progene_text",
"text": [
"P2X3"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_2566_entity",
"type": "progene_text",
"text": [
"ion channels"
],
"offsets": [
[
57,
69
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1614 | split_0_train_1614 | [
{
"id": "split_0_train_1614_passage",
"type": "progene_text",
"text": [
"Increasing evidence indicates its involvement in neuronal signaling and in pain ."
],
"offsets": [
[
0,
81
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1615 | split_0_train_1615 | [
{
"id": "split_0_train_1615_passage",
"type": "progene_text",
"text": [
"However , there is currently no selective inhibitor known for this subtype ."
],
"offsets": [
[
0,
76
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1616 | split_0_train_1616 | [
{
"id": "split_0_train_1616_passage",
"type": "progene_text",
"text": [
"In order to obtain such a specific inhibitor , a variety of antisense oligonucleotides ( ASO ) against rat P2X3 was tested , and dose - dependent , sequence - specific downregulation of the rat P2X3 receptor ( expressed in a Chinese hamster ovary cell line [ CHO - K1 ] ) on the mRNA , protein , and functional levels was observed ."
],
"offsets": [
[
0,
332
]
]
}
]
| [
{
"id": "split_0_train_2567_entity",
"type": "progene_text",
"text": [
"P2X3"
],
"offsets": [
[
107,
111
]
],
"normalized": []
},
{
"id": "split_0_train_2568_entity",
"type": "progene_text",
"text": [
"P2X3"
],
"offsets": [
[
194,
198
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1617 | split_0_train_1617 | [
{
"id": "split_0_train_1617_passage",
"type": "progene_text",
"text": [
"Using real - time quantitative PCR , a dose - dependent downregulation of P2X3 mRNA by ASO , as compared with untreated and mismatch controls , was demonstrated ."
],
"offsets": [
[
0,
162
]
]
}
]
| [
{
"id": "split_0_train_2569_entity",
"type": "progene_text",
"text": [
"P2X3"
],
"offsets": [
[
74,
78
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1618 | split_0_train_1618 | [
{
"id": "split_0_train_1618_passage",
"type": "progene_text",
"text": [
"Subsequently , downregulation by the two most potent ASO was confirmed at the protein level by Western blot ."
],
"offsets": [
[
0,
109
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1619 | split_0_train_1619 | [
{
"id": "split_0_train_1619_passage",
"type": "progene_text",
"text": [
"Sequence specificity was shown by titration of mismatches to the original selected oligonucleotide , and this correlated with progressive loss of P2X3 inhibition ."
],
"offsets": [
[
0,
163
]
]
}
]
| [
{
"id": "split_0_train_2570_entity",
"type": "progene_text",
"text": [
"P2X3"
],
"offsets": [
[
146,
150
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1620 | split_0_train_1620 | [
{
"id": "split_0_train_1620_passage",
"type": "progene_text",
"text": [
"The functional response of the P2X3 receptor was examined using whole - cell voltage clamping ."
],
"offsets": [
[
0,
95
]
]
}
]
| [
{
"id": "split_0_train_2571_entity",
"type": "progene_text",
"text": [
"P2X3"
],
"offsets": [
[
31,
35
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1621 | split_0_train_1621 | [
{
"id": "split_0_train_1621_passage",
"type": "progene_text",
"text": [
"Upon application of 10 microM of a nonspecific agonist , alpha,beta - methylene - ATP ( alphabeta meATP ) , pretreatment with increasing amounts of the most active ASO 5037 correlated with a decrease in depolarization ."
],
"offsets": [
[
0,
219
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1622 | split_0_train_1622 | [
{
"id": "split_0_train_1622_passage",
"type": "progene_text",
"text": [
"The ability to specifically downregulate the P2X3 receptor by ASO treatment will allow investigation of the biologic role of this receptor in neuronal tissues and eventually in in vivo models of chronic pain ."
],
"offsets": [
[
0,
209
]
]
}
]
| [
{
"id": "split_0_train_2572_entity",
"type": "progene_text",
"text": [
"P2X3"
],
"offsets": [
[
45,
49
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1623 | split_0_train_1623 | [
{
"id": "split_0_train_1623_passage",
"type": "progene_text",
"text": [
"Genomic organization and chromosomal localization of the Asna1 gene , a mouse homologue of a bacterial arsenic - translocating ATPase gene ."
],
"offsets": [
[
0,
140
]
]
}
]
| [
{
"id": "split_0_train_2573_entity",
"type": "progene_text",
"text": [
"Asna1"
],
"offsets": [
[
57,
62
]
],
"normalized": []
},
{
"id": "split_0_train_2574_entity",
"type": "progene_text",
"text": [
"ATPase"
],
"offsets": [
[
127,
133
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1624 | split_0_train_1624 | [
{
"id": "split_0_train_1624_passage",
"type": "progene_text",
"text": [
"The plasmid encoded ArsA ATPase in Escherichia coli is the catalytic component of an oxyanion pump that is responsible for resistance to arsenicals and antimonials ."
],
"offsets": [
[
0,
165
]
]
}
]
| [
{
"id": "split_0_train_2575_entity",
"type": "progene_text",
"text": [
"ArsA ATPase"
],
"offsets": [
[
20,
31
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1625 | split_0_train_1625 | [
{
"id": "split_0_train_1625_passage",
"type": "progene_text",
"text": [
"Arsenite or antimonite allosterically activates the ArsA ATPase activity ."
],
"offsets": [
[
0,
74
]
]
}
]
| [
{
"id": "split_0_train_2576_entity",
"type": "progene_text",
"text": [
"ArsA ATPase"
],
"offsets": [
[
52,
63
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1626 | split_0_train_1626 | [
{
"id": "split_0_train_1626_passage",
"type": "progene_text",
"text": [
"In this paper , we report the cloning and characterization of the mouse homologue ( Asna1 ) of the bacterial arsA gene ."
],
"offsets": [
[
0,
120
]
]
}
]
| [
{
"id": "split_0_train_2577_entity",
"type": "progene_text",
"text": [
"Asna1"
],
"offsets": [
[
84,
89
]
],
"normalized": []
},
{
"id": "split_0_train_2578_entity",
"type": "progene_text",
"text": [
"arsA"
],
"offsets": [
[
109,
113
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1627 | split_0_train_1627 | [
{
"id": "split_0_train_1627_passage",
"type": "progene_text",
"text": [
"The Asna1 gene encodes an open reading frame of 348 amino acids and exhibits 27 % identity to the bacterial ArsA protein and 99 % similarity to its human counterpart ( hASNA-1 ) ."
],
"offsets": [
[
0,
179
]
]
}
]
| [
{
"id": "split_0_train_2579_entity",
"type": "progene_text",
"text": [
"Asna1"
],
"offsets": [
[
4,
9
]
],
"normalized": []
},
{
"id": "split_0_train_2580_entity",
"type": "progene_text",
"text": [
"ArsA"
],
"offsets": [
[
108,
112
]
],
"normalized": []
},
{
"id": "split_0_train_2581_entity",
"type": "progene_text",
"text": [
"hASNA-1"
],
"offsets": [
[
168,
175
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1628 | split_0_train_1628 | [
{
"id": "split_0_train_1628_passage",
"type": "progene_text",
"text": [
"The Asna1 mRNA is a approximately 1.3 kb transcript and is present at high levels in kidney and testis , moderate levels in brain , liver , lung and skin , and low levels in heart , small intestine , spleen , stomach , and thymus ."
],
"offsets": [
[
0,
231
]
]
}
]
| [
{
"id": "split_0_train_2582_entity",
"type": "progene_text",
"text": [
"Asna1"
],
"offsets": [
[
4,
9
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1629 | split_0_train_1629 | [
{
"id": "split_0_train_1629_passage",
"type": "progene_text",
"text": [
"A negligible amount of Asna1 transcript is detected in skeletal muscle ."
],
"offsets": [
[
0,
72
]
]
}
]
| [
{
"id": "split_0_train_2583_entity",
"type": "progene_text",
"text": [
"Asna1"
],
"offsets": [
[
23,
28
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1630 | split_0_train_1630 | [
{
"id": "split_0_train_1630_passage",
"type": "progene_text",
"text": [
"We have also characterized the genomic structure of the Asna1 gene ."
],
"offsets": [
[
0,
68
]
]
}
]
| [
{
"id": "split_0_train_2584_entity",
"type": "progene_text",
"text": [
"Asna1"
],
"offsets": [
[
56,
61
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1631 | split_0_train_1631 | [
{
"id": "split_0_train_1631_passage",
"type": "progene_text",
"text": [
"The gene spans over 7 kb and consists of seven exons and six introns ."
],
"offsets": [
[
0,
70
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1632 | split_0_train_1632 | [
{
"id": "split_0_train_1632_passage",
"type": "progene_text",
"text": [
"All splice sites conform to the GT - AG rule , except for the splice donor site of intron 4 that is GC instead of GT ."
],
"offsets": [
[
0,
118
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1633 | split_0_train_1633 | [
{
"id": "split_0_train_1633_passage",
"type": "progene_text",
"text": [
"Fluorescence in situ hybridization indicates that the Asna1 gene is localized in the C3 - D1 region of mouse chromosome 8 ."
],
"offsets": [
[
0,
123
]
]
}
]
| [
{
"id": "split_0_train_2585_entity",
"type": "progene_text",
"text": [
"Asna1"
],
"offsets": [
[
54,
59
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1634 | split_0_train_1634 | [
{
"id": "split_0_train_1634_passage",
"type": "progene_text",
"text": [
"Effects of tri-iodothyronine on alternative splicing events in the coding region of cytochrome P450 aromatase in immature rat Sertoli cells ."
],
"offsets": [
[
0,
141
]
]
}
]
| [
{
"id": "split_0_train_2586_entity",
"type": "progene_text",
"text": [
"cytochrome P450 aromatase"
],
"offsets": [
[
84,
109
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1635 | split_0_train_1635 | [
{
"id": "split_0_train_1635_passage",
"type": "progene_text",
"text": [
"Transient postnatal hypothyroidism in male rats induces a prolonged proliferation of immature Sertoli cells ."
],
"offsets": [
[
0,
109
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1636 | split_0_train_1636 | [
{
"id": "split_0_train_1636_passage",
"type": "progene_text",
"text": [
"This change in Sertoli cell replication at young ages is coincident with enhanced and prolonged aromatase activity that leads to a marked increase in the conversion of androgens into estrogens ."
],
"offsets": [
[
0,
194
]
]
}
]
| [
{
"id": "split_0_train_2587_entity",
"type": "progene_text",
"text": [
"aromatase"
],
"offsets": [
[
96,
105
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1637 | split_0_train_1637 | [
{
"id": "split_0_train_1637_passage",
"type": "progene_text",
"text": [
"Both events are drastically inhibited by tri - iodothyronine ( T(3) ) replacement either in vivo or in vitro ."
],
"offsets": [
[
0,
110
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1638 | split_0_train_1638 | [
{
"id": "split_0_train_1638_passage",
"type": "progene_text",
"text": [
"This study , after the immunolocalization of aromatase in cultured rat Sertoli cells , examined the effects elicited by T(3) on this enzyme , by simultaneously investigating three functional levels of aromatase : mRNA expression , protein content , and enzymatic activity ."
],
"offsets": [
[
0,
273
]
]
}
]
| [
{
"id": "split_0_train_2588_entity",
"type": "progene_text",
"text": [
"aromatase"
],
"offsets": [
[
45,
54
]
],
"normalized": []
},
{
"id": "split_0_train_2589_entity",
"type": "progene_text",
"text": [
"aromatase"
],
"offsets": [
[
201,
210
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1639 | split_0_train_1639 | [
{
"id": "split_0_train_1639_passage",
"type": "progene_text",
"text": [
"The immunolocalization of cytochrome P450 aromatase ( P450 arom ) was shown in the cytoplasm of cultured Sertoli cells from 15 - and 21 - day - old rats ."
],
"offsets": [
[
0,
154
]
]
}
]
| [
{
"id": "split_0_train_2590_entity",
"type": "progene_text",
"text": [
"cytochrome P450 aromatase"
],
"offsets": [
[
26,
51
]
],
"normalized": []
},
{
"id": "split_0_train_2591_entity",
"type": "progene_text",
"text": [
"P450 arom"
],
"offsets": [
[
54,
63
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1640 | split_0_train_1640 | [
{
"id": "split_0_train_1640_passage",
"type": "progene_text",
"text": [
"Western blot analysis revealed an enhancement of aromatase protein content upon stimulation with N(6),2'-O-dibutyryladenosine-3':5'-cyclic monophosphate ((Bu)(2)cAMP ) that was clearly down - regulated by T(3) ."
],
"offsets": [
[
0,
211
]
]
}
]
| [
{
"id": "split_0_train_2592_entity",
"type": "progene_text",
"text": [
"aromatase"
],
"offsets": [
[
49,
58
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1641 | split_0_train_1641 | [
{
"id": "split_0_train_1641_passage",
"type": "progene_text",
"text": [
"The presence of a functional P450 arom protein in purified Sertoli cells was confirmed by the measurement of [(3)H]H(2)O released after incubation with [1 beta-(3)H]androst-4-ene-3,17-dione ."
],
"offsets": [
[
0,
191
]
]
}
]
| [
{
"id": "split_0_train_2593_entity",
"type": "progene_text",
"text": [
"P450 arom"
],
"offsets": [
[
29,
38
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1642 | split_0_train_1642 | [
{
"id": "split_0_train_1642_passage",
"type": "progene_text",
"text": [
"With 100 nM T3 , a decrease in both P450 arom mRNA levels and aromatase activity was observed ."
],
"offsets": [
[
0,
95
]
]
}
]
| [
{
"id": "split_0_train_2594_entity",
"type": "progene_text",
"text": [
"P450 arom"
],
"offsets": [
[
36,
45
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1643 | split_0_train_1643 | [
{
"id": "split_0_train_1643_passage",
"type": "progene_text",
"text": [
"The aromatase enzymatic activity was strongly stimulated by (Bu)(2)cAMP and markedly down - regulated by T(3) ."
],
"offsets": [
[
0,
111
]
]
}
]
| [
{
"id": "split_0_train_2595_entity",
"type": "progene_text",
"text": [
"aromatase"
],
"offsets": [
[
4,
13
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1644 | split_0_train_1644 | [
{
"id": "split_0_train_1644_passage",
"type": "progene_text",
"text": [
"In contrast , the strong increase in aromatase mRNA upon (Bu)(2)cAMP stimulation was apparently unaffected by T(3) administration ."
],
"offsets": [
[
0,
131
]
]
}
]
| [
{
"id": "split_0_train_2596_entity",
"type": "progene_text",
"text": [
"aromatase"
],
"offsets": [
[
37,
46
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1645 | split_0_train_1645 | [
{
"id": "split_0_train_1645_passage",
"type": "progene_text",
"text": [
"This paper shows how the identification of an altered transcript induced by T(3) coding for putative truncated and inactive aromatase protein might explain such a decrease in aromatase activity in T(3) - treated cells ."
],
"offsets": [
[
0,
219
]
]
}
]
| [
{
"id": "split_0_train_2597_entity",
"type": "progene_text",
"text": [
"aromatase"
],
"offsets": [
[
124,
133
]
],
"normalized": []
},
{
"id": "split_0_train_2598_entity",
"type": "progene_text",
"text": [
"aromatase"
],
"offsets": [
[
175,
184
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1646 | split_0_train_1646 | [
{
"id": "split_0_train_1646_passage",
"type": "progene_text",
"text": [
"On the basis of these results , it is concluded that at least two mechanisms could be involved in the down - regulatory effect of T(3) on aromatase activity in prepuberal Sertoli cells ."
],
"offsets": [
[
0,
186
]
]
}
]
| [
{
"id": "split_0_train_2599_entity",
"type": "progene_text",
"text": [
"aromatase"
],
"offsets": [
[
138,
147
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1647 | split_0_train_1647 | [
{
"id": "split_0_train_1647_passage",
"type": "progene_text",
"text": [
"The first mechanism is linked to a possible direct modulatory role for T(3) in the regulation of the aromatase promoter , whilst the second one is represented by the induction of altered transcripts coding for truncated and inactive aromatase proteins ."
],
"offsets": [
[
0,
253
]
]
}
]
| [
{
"id": "split_0_train_2600_entity",
"type": "progene_text",
"text": [
"aromatase"
],
"offsets": [
[
101,
110
]
],
"normalized": []
},
{
"id": "split_0_train_2601_entity",
"type": "progene_text",
"text": [
"aromatase"
],
"offsets": [
[
233,
242
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1648 | split_0_train_1648 | [
{
"id": "split_0_train_1648_passage",
"type": "progene_text",
"text": [
"Characterization of the human ABCG1 gene : liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein ."
],
"offsets": [
[
0,
169
]
]
}
]
| [
{
"id": "split_0_train_2602_entity",
"type": "progene_text",
"text": [
"ABCG1"
],
"offsets": [
[
30,
35
]
],
"normalized": []
},
{
"id": "split_0_train_2603_entity",
"type": "progene_text",
"text": [
"liver X receptor"
],
"offsets": [
[
43,
59
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1649 | split_0_train_1649 | [
{
"id": "split_0_train_1649_passage",
"type": "progene_text",
"text": [
"The human ABCG1 gene encodes a member of the ATP - binding cassette ( ABC ) superfamily of transporter proteins and is highly induced when macrophages are incubated with oxysterols ."
],
"offsets": [
[
0,
182
]
]
}
]
| [
{
"id": "split_0_train_2604_entity",
"type": "progene_text",
"text": [
"ABCG1"
],
"offsets": [
[
10,
15
]
],
"normalized": []
},
{
"id": "split_0_train_2605_entity",
"type": "progene_text",
"text": [
"ATP - binding cassette ( ABC ) superfamily of transporter proteins"
],
"offsets": [
[
45,
111
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1650 | split_0_train_1650 | [
{
"id": "split_0_train_1650_passage",
"type": "progene_text",
"text": [
"Using mRNA from oxysterol - treated human THP-1 cells together with 5'-rapid amplification of cDNA ends and polymerase chain reaction , we identified a novel ABCG1 transcript that encodes a putative protein of 786 residues containing a new amino terminus of 203 amino acids ."
],
"offsets": [
[
0,
275
]
]
}
]
| [
{
"id": "split_0_train_2606_entity",
"type": "progene_text",
"text": [
"ABCG1"
],
"offsets": [
[
158,
163
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1651 | split_0_train_1651 | [
{
"id": "split_0_train_1651_passage",
"type": "progene_text",
"text": [
"Characterization of the genomic organization and structure of the human ABCG1 gene demonstrates that : (i) the gene consists of 23 exons spanning 98 kilobase pairs ( kb ) on chromosome 21q22.3 , (ii) the 203 amino acids are encoded on three previously unidentified exons , 8-10 , and (iii) a promoter , containing a TATA box and two liver X receptor ( LXR ) alpha response elements ( LXREs ) , is located upstream of exon 8 ."
],
"offsets": [
[
0,
425
]
]
}
]
| [
{
"id": "split_0_train_2607_entity",
"type": "progene_text",
"text": [
"ABCG1"
],
"offsets": [
[
72,
77
]
],
"normalized": []
},
{
"id": "split_0_train_2608_entity",
"type": "progene_text",
"text": [
"liver X receptor ( LXR ) alpha"
],
"offsets": [
[
333,
363
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1652 | split_0_train_1652 | [
{
"id": "split_0_train_1652_passage",
"type": "progene_text",
"text": [
"Northern analysis using exon - specific probes confirms that oxysterol treatment results in > 10 - fold induction of ABCG1 transcripts that are derived from either exons 8 - 23 or exons 5 , 7 , and 11-23 ."
],
"offsets": [
[
0,
205
]
]
}
]
| [
{
"id": "split_0_train_2609_entity",
"type": "progene_text",
"text": [
"ABCG1"
],
"offsets": [
[
117,
122
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1653 | split_0_train_1653 | [
{
"id": "split_0_train_1653_passage",
"type": "progene_text",
"text": [
"Electromobility shift assays demonstrate that LXRalpha and retinoid X receptor alpha bind to the two LXREs in intron 7 ."
],
"offsets": [
[
0,
120
]
]
}
]
| [
{
"id": "split_0_train_2610_entity",
"type": "progene_text",
"text": [
"LXRalpha"
],
"offsets": [
[
46,
54
]
],
"normalized": []
},
{
"id": "split_0_train_2611_entity",
"type": "progene_text",
"text": [
"retinoid X receptor alpha"
],
"offsets": [
[
59,
84
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1654 | split_0_train_1654 | [
{
"id": "split_0_train_1654_passage",
"type": "progene_text",
"text": [
"Cells were transiently transfected with reporter luciferase constructs under the control of either (i) 9 kb of genomic DNA corresponding to intron 7 and part of exon 8 and containing either wild - type or mutant LXREs or (ii) two copies of the wild - type or mutant LXRE ."
],
"offsets": [
[
0,
272
]
]
}
]
| [
{
"id": "split_0_train_2612_entity",
"type": "progene_text",
"text": [
"luciferase"
],
"offsets": [
[
49,
59
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1655 | split_0_train_1655 | [
{
"id": "split_0_train_1655_passage",
"type": "progene_text",
"text": [
"In all cases , the wild - type construct was regulated in an LXR - and oxysterol - dependent manner , and this regulation was attenuated when the LXREs were mutated ."
],
"offsets": [
[
0,
166
]
]
}
]
| [
{
"id": "split_0_train_2613_entity",
"type": "progene_text",
"text": [
"LXR"
],
"offsets": [
[
61,
64
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1656 | split_0_train_1656 | [
{
"id": "split_0_train_1656_passage",
"type": "progene_text",
"text": [
"In conclusion , the human ABCG1 gene contains multiple promoters , spans more than 98 kb and comprises 23 exons that give rise to alternative transcripts encoding proteins with different amino - terminal sequences ."
],
"offsets": [
[
0,
215
]
]
}
]
| [
{
"id": "split_0_train_2614_entity",
"type": "progene_text",
"text": [
"ABCG1"
],
"offsets": [
[
26,
31
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1657 | split_0_train_1657 | [
{
"id": "split_0_train_1657_passage",
"type": "progene_text",
"text": [
"Elucidation of the various roles of different ABCG1 isoforms will be important for our understanding of mammalian cholesterol homeostasis ."
],
"offsets": [
[
0,
139
]
]
}
]
| [
{
"id": "split_0_train_2615_entity",
"type": "progene_text",
"text": [
"ABCG1"
],
"offsets": [
[
46,
51
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1658 | split_0_train_1658 | [
{
"id": "split_0_train_1658_passage",
"type": "progene_text",
"text": [
"Interaction of Myc - associated zinc finger protein with DCC , the product of a tumor - suppressor gene , during the neural differentiation of P19 EC cells ."
],
"offsets": [
[
0,
157
]
]
}
]
| [
{
"id": "split_0_train_2616_entity",
"type": "progene_text",
"text": [
"Myc - associated zinc finger"
],
"offsets": [
[
15,
43
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1659 | split_0_train_1659 | [
{
"id": "split_0_train_1659_passage",
"type": "progene_text",
"text": [
"Expression of the DCC ( deleted in colorectal cancer ) protein is strongly induced during the neural differentiation of mouse P19 embryonal carcinoma ( EC ) cells that occurs when these cells are treated with retinoic acid ( RA ) ."
],
"offsets": [
[
0,
231
]
]
}
]
| [
{
"id": "split_0_train_2617_entity",
"type": "progene_text",
"text": [
"DCC"
],
"offsets": [
[
18,
21
]
],
"normalized": []
},
{
"id": "split_0_train_2618_entity",
"type": "progene_text",
"text": [
"deleted in colorectal cancer"
],
"offsets": [
[
24,
52
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1660 | split_0_train_1660 | [
{
"id": "split_0_train_1660_passage",
"type": "progene_text",
"text": [
"Myc - associated zinc finger protein ( MAZ ) is a DNA - binding protein that is widely expressed and functions in human , mouse and hamster cells as an activator , an initiator or a terminator of transcription ."
],
"offsets": [
[
0,
211
]
]
}
]
| [
{
"id": "split_0_train_2619_entity",
"type": "progene_text",
"text": [
"Myc - associated zinc finger"
],
"offsets": [
[
0,
28
]
],
"normalized": []
},
{
"id": "split_0_train_2620_entity",
"type": "progene_text",
"text": [
"MAZ"
],
"offsets": [
[
39,
42
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1661 | split_0_train_1661 | [
{
"id": "split_0_train_1661_passage",
"type": "progene_text",
"text": [
"However , the biological functions of MAZ remain elusive ."
],
"offsets": [
[
0,
58
]
]
}
]
| [
{
"id": "split_0_train_2621_entity",
"type": "progene_text",
"text": [
"MAZ"
],
"offsets": [
[
38,
41
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1662 | split_0_train_1662 | [
{
"id": "split_0_train_1662_passage",
"type": "progene_text",
"text": [
"We report here that MAZ associates with the cytoplasmic domain of the DCC protein in vivo and in vitro ."
],
"offsets": [
[
0,
104
]
]
}
]
| [
{
"id": "split_0_train_2622_entity",
"type": "progene_text",
"text": [
"MAZ"
],
"offsets": [
[
20,
23
]
],
"normalized": []
},
{
"id": "split_0_train_2623_entity",
"type": "progene_text",
"text": [
"DCC"
],
"offsets": [
[
70,
73
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1663 | split_0_train_1663 | [
{
"id": "split_0_train_1663_passage",
"type": "progene_text",
"text": [
"Yeast two - hybrid assays confirmed this association ."
],
"offsets": [
[
0,
54
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1664 | split_0_train_1664 | [
{
"id": "split_0_train_1664_passage",
"type": "progene_text",
"text": [
"An immunofluorescence study demonstrated that DCC protein is expressed at elevated levels in neuron - like P19 EC cells , in particular in axons , in which the MAZ protein is also expressed ."
],
"offsets": [
[
0,
191
]
]
}
]
| [
{
"id": "split_0_train_2624_entity",
"type": "progene_text",
"text": [
"DCC"
],
"offsets": [
[
46,
49
]
],
"normalized": []
},
{
"id": "split_0_train_2625_entity",
"type": "progene_text",
"text": [
"MAZ"
],
"offsets": [
[
160,
163
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1665 | split_0_train_1665 | [
{
"id": "split_0_train_1665_passage",
"type": "progene_text",
"text": [
"We found that MAZ was translocated from the nucleus to the cytoplasm during the RA - induced terminal differentiation of P19 EC cells with resultant loss of the ability of MAZ to bind to the ME1a1 site of the c-myc promoter ."
],
"offsets": [
[
0,
225
]
]
}
]
| [
{
"id": "split_0_train_2626_entity",
"type": "progene_text",
"text": [
"MAZ"
],
"offsets": [
[
14,
17
]
],
"normalized": []
},
{
"id": "split_0_train_2627_entity",
"type": "progene_text",
"text": [
"MAZ"
],
"offsets": [
[
172,
175
]
],
"normalized": []
},
{
"id": "split_0_train_2628_entity",
"type": "progene_text",
"text": [
"c-myc"
],
"offsets": [
[
209,
214
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1666 | split_0_train_1666 | [
{
"id": "split_0_train_1666_passage",
"type": "progene_text",
"text": [
"Taken together , our observations imply that the DCC protein might play a critical role as a signaling molecule in the regulation of the transcriptional activity of MAZ during the neural differentiation of P19 EC cells ."
],
"offsets": [
[
0,
220
]
]
}
]
| [
{
"id": "split_0_train_2629_entity",
"type": "progene_text",
"text": [
"DCC"
],
"offsets": [
[
49,
52
]
],
"normalized": []
},
{
"id": "split_0_train_2630_entity",
"type": "progene_text",
"text": [
"MAZ"
],
"offsets": [
[
165,
168
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1667 | split_0_train_1667 | [
{
"id": "split_0_train_1667_passage",
"type": "progene_text",
"text": [
"Characterization of inhibitors acting at the synthetase site of Escherichia coli asparagine synthetase B ."
],
"offsets": [
[
0,
106
]
]
}
]
| [
{
"id": "split_0_train_2631_entity",
"type": "progene_text",
"text": [
"synthetase"
],
"offsets": [
[
45,
55
]
],
"normalized": []
},
{
"id": "split_0_train_2632_entity",
"type": "progene_text",
"text": [
"asparagine synthetase B"
],
"offsets": [
[
81,
104
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1668 | split_0_train_1668 | [
{
"id": "split_0_train_1668_passage",
"type": "progene_text",
"text": [
"Asparagine synthetase catalyzes the ATP - dependent formation of L-asparagine from L-aspartate and L-glutamine , via a beta-aspartyl-AMP intermediate ."
],
"offsets": [
[
0,
151
]
]
}
]
| [
{
"id": "split_0_train_2633_entity",
"type": "progene_text",
"text": [
"Asparagine synthetase"
],
"offsets": [
[
0,
21
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1669 | split_0_train_1669 | [
{
"id": "split_0_train_1669_passage",
"type": "progene_text",
"text": [
"Since interfering with this enzyme activity might be useful for treating leukemia and solid tumors , we have sought small - molecule inhibitors of Escherichia coli asparagine synthetase B ( AS-B ) as a model system for the human enzyme ."
],
"offsets": [
[
0,
237
]
]
}
]
| [
{
"id": "split_0_train_2634_entity",
"type": "progene_text",
"text": [
"asparagine synthetase B"
],
"offsets": [
[
164,
187
]
],
"normalized": []
},
{
"id": "split_0_train_2635_entity",
"type": "progene_text",
"text": [
"AS-B"
],
"offsets": [
[
190,
194
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1670 | split_0_train_1670 | [
{
"id": "split_0_train_1670_passage",
"type": "progene_text",
"text": [
"Prior work showed that L-cysteine sulfinic acid competitively inhibits this enzyme by interfering with L-aspartate binding ."
],
"offsets": [
[
0,
124
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1671 | split_0_train_1671 | [
{
"id": "split_0_train_1671_passage",
"type": "progene_text",
"text": [
"Here , we demonstrate that cysteine sulfinic acid is also a partial substrate for E. coli asparagine synthetase , acting as a nucleophile to form the sulfur analogue of beta-aspartyl-AMP , which is subsequently hydrolyzed back to cysteine sulfinic acid and AMP in a futile cycle ."
],
"offsets": [
[
0,
280
]
]
}
]
| [
{
"id": "split_0_train_2636_entity",
"type": "progene_text",
"text": [
"asparagine synthetase"
],
"offsets": [
[
90,
111
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1672 | split_0_train_1672 | [
{
"id": "split_0_train_1672_passage",
"type": "progene_text",
"text": [
"While cysteine sulfinic acid did not itself constitute a clinically useful inhibitor of asparagine synthetase B , these results suggested that replacing this linkage by a more stable analogue might lead to a more potent inhibitor ."
],
"offsets": [
[
0,
231
]
]
}
]
| [
{
"id": "split_0_train_2637_entity",
"type": "progene_text",
"text": [
"asparagine synthetase B"
],
"offsets": [
[
88,
111
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1673 | split_0_train_1673 | [
{
"id": "split_0_train_1673_passage",
"type": "progene_text",
"text": [
"A sulfoximine reported recently by Koizumi et al. as a competitive inhibitor of the ammonia - dependent E. coli asparagine synthetase A ( AS-A ) [ Koizumi , M. , Hiratake , J. , Nakatsu , T. , Kato , H. , and Oda , J. ( 1999 ) J. Am. Chem. Soc. 121 , 5799 - 5800 ] can be regarded as such a species ."
],
"offsets": [
[
0,
300
]
]
}
]
| [
{
"id": "split_0_train_2638_entity",
"type": "progene_text",
"text": [
"asparagine synthetase A"
],
"offsets": [
[
112,
135
]
],
"normalized": []
},
{
"id": "split_0_train_2639_entity",
"type": "progene_text",
"text": [
"AS-A"
],
"offsets": [
[
138,
142
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1674 | split_0_train_1674 | [
{
"id": "split_0_train_1674_passage",
"type": "progene_text",
"text": [
"We found that this sulfoximine also inhibited AS-B , effectively irreversibly ."
],
"offsets": [
[
0,
79
]
]
}
]
| [
{
"id": "split_0_train_2640_entity",
"type": "progene_text",
"text": [
"AS-B"
],
"offsets": [
[
46,
50
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1675 | split_0_train_1675 | [
{
"id": "split_0_train_1675_passage",
"type": "progene_text",
"text": [
"Unlike either the cysteine sulfinic acid interaction with AS-B or the sulfoximine interaction with AS-A , only AS-B productively engaged in asparagine synthesis could be inactivated by the sulfoximine ; free enzyme was unaffected even after extended incubation with the sulfoximine ."
],
"offsets": [
[
0,
283
]
]
}
]
| [
{
"id": "split_0_train_2641_entity",
"type": "progene_text",
"text": [
"AS-B"
],
"offsets": [
[
58,
62
]
],
"normalized": []
},
{
"id": "split_0_train_2642_entity",
"type": "progene_text",
"text": [
"AS-A"
],
"offsets": [
[
99,
103
]
],
"normalized": []
},
{
"id": "split_0_train_2643_entity",
"type": "progene_text",
"text": [
"AS-B"
],
"offsets": [
[
111,
115
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1676 | split_0_train_1676 | [
{
"id": "split_0_train_1676_passage",
"type": "progene_text",
"text": [
"Taken together , these results support the notion that sulfur - containing analogues of aspartate can serve as platforms for developing useful inhibitors of AS-B ."
],
"offsets": [
[
0,
163
]
]
}
]
| [
{
"id": "split_0_train_2644_entity",
"type": "progene_text",
"text": [
"AS-B"
],
"offsets": [
[
157,
161
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1677 | split_0_train_1677 | [
{
"id": "split_0_train_1677_passage",
"type": "progene_text",
"text": [
"Mutations in the human orthologue of the mouse underwhite gene ( uw ) underlie a new form of oculocutaneous albinism , OCA4 ."
],
"offsets": [
[
0,
125
]
]
}
]
| [
{
"id": "split_0_train_2645_entity",
"type": "progene_text",
"text": [
"underwhite"
],
"offsets": [
[
47,
57
]
],
"normalized": []
},
{
"id": "split_0_train_2646_entity",
"type": "progene_text",
"text": [
"uw"
],
"offsets": [
[
65,
67
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1678 | split_0_train_1678 | [
{
"id": "split_0_train_1678_passage",
"type": "progene_text",
"text": [
"Oculocutaneous albinism ( OCA ) affects approximately 1 / 20,000 people worldwide ."
],
"offsets": [
[
0,
83
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1679 | split_0_train_1679 | [
{
"id": "split_0_train_1679_passage",
"type": "progene_text",
"text": [
"All forms of OCA exhibit generalized hypopigmentation ."
],
"offsets": [
[
0,
55
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1680 | split_0_train_1680 | [
{
"id": "split_0_train_1680_passage",
"type": "progene_text",
"text": [
"Reduced pigmentation during eye development results in misrouting of the optic nerves , nystagmus , alternating strabismus , and reduced visual acuity ."
],
"offsets": [
[
0,
152
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1681 | split_0_train_1681 | [
{
"id": "split_0_train_1681_passage",
"type": "progene_text",
"text": [
"Loss of pigmentation in the skin leads to an increased risk for skin cancer ."
],
"offsets": [
[
0,
77
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1682 | split_0_train_1682 | [
{
"id": "split_0_train_1682_passage",
"type": "progene_text",
"text": [
"Two common forms and one infrequent form of OCA have been described ."
],
"offsets": [
[
0,
69
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1683 | split_0_train_1683 | [
{
"id": "split_0_train_1683_passage",
"type": "progene_text",
"text": [
"OCA1 ( MIM 203100 ) is associated with mutations of the TYR gene encoding tyrosinase ( the rate - limiting enzyme in the production of melanin pigment ) and accounts for approximately 40 % of OCA worldwide ."
],
"offsets": [
[
0,
207
]
]
}
]
| [
{
"id": "split_0_train_2647_entity",
"type": "progene_text",
"text": [
"TYR"
],
"offsets": [
[
56,
59
]
],
"normalized": []
},
{
"id": "split_0_train_2648_entity",
"type": "progene_text",
"text": [
"tyrosinase"
],
"offsets": [
[
74,
84
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1684 | split_0_train_1684 | [
{
"id": "split_0_train_1684_passage",
"type": "progene_text",
"text": [
"OCA2 ( MIM 203200 ) , the most common form of OCA , is associated with mutations of the P gene and accounts for approximately 50 % of OCA worldwide ."
],
"offsets": [
[
0,
149
]
]
}
]
| [
{
"id": "split_0_train_2649_entity",
"type": "progene_text",
"text": [
"P"
],
"offsets": [
[
88,
89
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1685 | split_0_train_1685 | [
{
"id": "split_0_train_1685_passage",
"type": "progene_text",
"text": [
"OCA3 ( MIM 203290 ) , a rare form of OCA and also known as \" rufous / red albinism , \" is associated with mutations in TYRP1 ( encoding tyrosinase - related protein 1 ) ."
],
"offsets": [
[
0,
170
]
]
}
]
| [
{
"id": "split_0_train_2650_entity",
"type": "progene_text",
"text": [
"TYRP1"
],
"offsets": [
[
119,
124
]
],
"normalized": []
},
{
"id": "split_0_train_2651_entity",
"type": "progene_text",
"text": [
"tyrosinase - related protein 1"
],
"offsets": [
[
136,
166
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1686 | split_0_train_1686 | [
{
"id": "split_0_train_1686_passage",
"type": "progene_text",
"text": [
"Analysis of the TYR and P genes in patients with OCA suggests that other genes may be associated with OCA ."
],
"offsets": [
[
0,
107
]
]
}
]
| [
{
"id": "split_0_train_2652_entity",
"type": "progene_text",
"text": [
"TYR"
],
"offsets": [
[
16,
19
]
],
"normalized": []
},
{
"id": "split_0_train_2653_entity",
"type": "progene_text",
"text": [
"P"
],
"offsets": [
[
24,
25
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1687 | split_0_train_1687 | [
{
"id": "split_0_train_1687_passage",
"type": "progene_text",
"text": [
"We have identified the mouse underwhite gene ( uw ) and its human orthologue , which underlies a new form of human OCA , termed \" OCA4. \""
],
"offsets": [
[
0,
137
]
]
}
]
| [
{
"id": "split_0_train_2654_entity",
"type": "progene_text",
"text": [
"underwhite"
],
"offsets": [
[
29,
39
]
],
"normalized": []
},
{
"id": "split_0_train_2655_entity",
"type": "progene_text",
"text": [
"uw"
],
"offsets": [
[
47,
49
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1688 | split_0_train_1688 | [
{
"id": "split_0_train_1688_passage",
"type": "progene_text",
"text": [
"The encoded protein , MATP ( for \" membrane - associated transporter protein \" ) is predicted to span the membrane 12 times and likely functions as a transporter ."
],
"offsets": [
[
0,
163
]
]
}
]
| [
{
"id": "split_0_train_2656_entity",
"type": "progene_text",
"text": [
"MATP"
],
"offsets": [
[
22,
26
]
],
"normalized": []
},
{
"id": "split_0_train_2657_entity",
"type": "progene_text",
"text": [
"membrane - associated transporter protein"
],
"offsets": [
[
35,
76
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1689 | split_0_train_1689 | [
{
"id": "split_0_train_1689_passage",
"type": "progene_text",
"text": [
"Direct ligand - receptor complex interaction controls Brassica self - incompatibility ."
],
"offsets": [
[
0,
87
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1690 | split_0_train_1690 | [
{
"id": "split_0_train_1690_passage",
"type": "progene_text",
"text": [
"Many higher plants have evolved self - incompatibility mechanisms to prevent self - fertilization ."
],
"offsets": [
[
0,
99
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1691 | split_0_train_1691 | [
{
"id": "split_0_train_1691_passage",
"type": "progene_text",
"text": [
"In Brassica self - incompatibility , recognition between pollen and the stigma is controlled by the S locus , which contains three highly polymorphic genes : S-receptor kinase ( SRK ) , S-locus protein 11 ( SP11 ) ( also called S-locus cysteine - rich protein ; SCR ) and S-locus glycoprotein ( SLG ) ."
],
"offsets": [
[
0,
302
]
]
}
]
| [
{
"id": "split_0_train_2658_entity",
"type": "progene_text",
"text": [
"S-receptor kinase"
],
"offsets": [
[
158,
175
]
],
"normalized": []
},
{
"id": "split_0_train_2659_entity",
"type": "progene_text",
"text": [
"SRK"
],
"offsets": [
[
178,
181
]
],
"normalized": []
},
{
"id": "split_0_train_2660_entity",
"type": "progene_text",
"text": [
"S-locus protein 11"
],
"offsets": [
[
186,
204
]
],
"normalized": []
},
{
"id": "split_0_train_2661_entity",
"type": "progene_text",
"text": [
"SP11"
],
"offsets": [
[
207,
211
]
],
"normalized": []
},
{
"id": "split_0_train_2662_entity",
"type": "progene_text",
"text": [
"S-locus cysteine - rich protein"
],
"offsets": [
[
228,
259
]
],
"normalized": []
},
{
"id": "split_0_train_2663_entity",
"type": "progene_text",
"text": [
"SCR"
],
"offsets": [
[
262,
265
]
],
"normalized": []
},
{
"id": "split_0_train_2664_entity",
"type": "progene_text",
"text": [
"S-locus glycoprotein"
],
"offsets": [
[
272,
292
]
],
"normalized": []
},
{
"id": "split_0_train_2665_entity",
"type": "progene_text",
"text": [
"SLG"
],
"offsets": [
[
295,
298
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1692 | split_0_train_1692 | [
{
"id": "split_0_train_1692_passage",
"type": "progene_text",
"text": [
"SRK encodes a membrane - spanning serine / threonine kinase that determines the S-haplotype specificity of the stigma , and SP11 encodes a small cysteine - rich protein that determines the S-haplotype specificity of pollen ."
],
"offsets": [
[
0,
224
]
]
}
]
| [
{
"id": "split_0_train_2666_entity",
"type": "progene_text",
"text": [
"SRK"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_2667_entity",
"type": "progene_text",
"text": [
"serine / threonine kinase"
],
"offsets": [
[
34,
59
]
],
"normalized": []
},
{
"id": "split_0_train_2668_entity",
"type": "progene_text",
"text": [
"SP11"
],
"offsets": [
[
124,
128
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1693 | split_0_train_1693 | [
{
"id": "split_0_train_1693_passage",
"type": "progene_text",
"text": [
"SP11 is localized in the pollen coat ."
],
"offsets": [
[
0,
38
]
]
}
]
| [
{
"id": "split_0_train_2669_entity",
"type": "progene_text",
"text": [
"SP11"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1694 | split_0_train_1694 | [
{
"id": "split_0_train_1694_passage",
"type": "progene_text",
"text": [
"It is thought that , during self - pollination , SP11 is secreted from the pollen coat and interacts with its cognate SRK in the papilla cell of the stigma to elicit the self - incompatibility response ."
],
"offsets": [
[
0,
203
]
]
}
]
| [
{
"id": "split_0_train_2670_entity",
"type": "progene_text",
"text": [
"SP11"
],
"offsets": [
[
49,
53
]
],
"normalized": []
},
{
"id": "split_0_train_2671_entity",
"type": "progene_text",
"text": [
"SRK"
],
"offsets": [
[
118,
121
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1695 | split_0_train_1695 | [
{
"id": "split_0_train_1695_passage",
"type": "progene_text",
"text": [
"SLG is a secreted stigma protein that is highly homologous to the SRK extracellular domain ."
],
"offsets": [
[
0,
92
]
]
}
]
| [
{
"id": "split_0_train_2672_entity",
"type": "progene_text",
"text": [
"SLG"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_2673_entity",
"type": "progene_text",
"text": [
"SRK"
],
"offsets": [
[
66,
69
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1696 | split_0_train_1696 | [
{
"id": "split_0_train_1696_passage",
"type": "progene_text",
"text": [
"Although it is not required for S-haplotype specificity of the stigma , SLG enhances the self - incompatibility response ; however , how this is accomplished remains controversial ."
],
"offsets": [
[
0,
181
]
]
}
]
| [
{
"id": "split_0_train_2674_entity",
"type": "progene_text",
"text": [
"SLG"
],
"offsets": [
[
72,
75
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1697 | split_0_train_1697 | [
{
"id": "split_0_train_1697_passage",
"type": "progene_text",
"text": [
"Here we show that a single form of SP11 of the S8 haplotype ( S8 - SP11 ) stabilized with four intramolecular disulphide bonds specifically binds the stigma membrane of the S8 haplotype to induce autophosphorylation of SRK8 , and that SRK8 and SLG8 together form a high - affinity receptor complex for S8 - SP11 on the stigma membrane ."
],
"offsets": [
[
0,
336
]
]
}
]
| [
{
"id": "split_0_train_2675_entity",
"type": "progene_text",
"text": [
"SP11"
],
"offsets": [
[
35,
39
]
],
"normalized": []
},
{
"id": "split_0_train_2676_entity",
"type": "progene_text",
"text": [
"SP11"
],
"offsets": [
[
67,
71
]
],
"normalized": []
},
{
"id": "split_0_train_2677_entity",
"type": "progene_text",
"text": [
"SRK8"
],
"offsets": [
[
219,
223
]
],
"normalized": []
},
{
"id": "split_0_train_2678_entity",
"type": "progene_text",
"text": [
"SRK8"
],
"offsets": [
[
235,
239
]
],
"normalized": []
},
{
"id": "split_0_train_2679_entity",
"type": "progene_text",
"text": [
"SLG8"
],
"offsets": [
[
244,
248
]
],
"normalized": []
},
{
"id": "split_0_train_2680_entity",
"type": "progene_text",
"text": [
"SP11"
],
"offsets": [
[
307,
311
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_1698 | split_0_train_1698 | [
{
"id": "split_0_train_1698_passage",
"type": "progene_text",
"text": [
"Effect of orally administered cimetidine and ranitidine on abomasal luminal pH in clinically normal milk - fed calves ."
],
"offsets": [
[
0,
119
]
]
}
]
| []
| []
| []
| []
|
split_0_train_1699 | split_0_train_1699 | [
{
"id": "split_0_train_1699_passage",
"type": "progene_text",
"text": [
"OBJECTIVE :"
],
"offsets": [
[
0,
11
]
]
}
]
| []
| []
| []
| []
|
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