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stringlengths 15
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| passages
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list | events
list | coreferences
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|---|---|---|---|---|---|---|
split_0_train_30300 | split_0_train_30300 | [
{
"id": "split_0_train_30300_passage",
"type": "progene_text",
"text": [
"We isolated the chicken interleukin-12 ( ChIL-12 ) p40 cDNA from a concanavalin A ( ConA ) - stimulated spleen cDNA library using the PCR with primers based on a partial 3' EST sequence in a chicken EST library ."
],
"offsets": [
[
0,
212
]
]
}
] | [
{
"id": "split_0_train_49024_entity",
"type": "progene_text",
"text": [
"interleukin-12 ( ChIL-12 ) p40"
],
"offsets": [
[
24,
54
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30301 | split_0_train_30301 | [
{
"id": "split_0_train_30301_passage",
"type": "progene_text",
"text": [
"The cDNA encodes a polypeptide of 315 amino acids ( aa ) , with a predicted mature peptide of 300 aa ."
],
"offsets": [
[
0,
102
]
]
}
] | [] | [] | [] | [] |
split_0_train_30302 | split_0_train_30302 | [
{
"id": "split_0_train_30302_passage",
"type": "progene_text",
"text": [
"ChIL-12 p40 has 46 % and 41 % amino acid identity with human ( HuIL-12 ) and murine IL-12 ( MuIL - 12 ) p40 , respectively ."
],
"offsets": [
[
0,
124
]
]
}
] | [
{
"id": "split_0_train_49025_entity",
"type": "progene_text",
"text": [
"ChIL-12 p40"
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"offsets": [
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0,
11
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},
{
"id": "split_0_train_49026_entity",
"type": "progene_text",
"text": [
"HuIL-12"
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[
63,
70
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],
"normalized": []
},
{
"id": "split_0_train_49027_entity",
"type": "progene_text",
"text": [
"IL-12 ( MuIL - 12 ) p40"
],
"offsets": [
[
84,
107
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30303 | split_0_train_30303 | [
{
"id": "split_0_train_30303_passage",
"type": "progene_text",
"text": [
"We also isolated a partial turkey IL-12 ( TuIL-12 ) p40 cDNA sequence with 95 % predicted aa identity with ChIL-12 p40 ."
],
"offsets": [
[
0,
120
]
]
}
] | [
{
"id": "split_0_train_49028_entity",
"type": "progene_text",
"text": [
"IL-12 ( TuIL-12 ) p40"
],
"offsets": [
[
34,
55
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],
"normalized": []
},
{
"id": "split_0_train_49029_entity",
"type": "progene_text",
"text": [
"ChIL-12 p40"
],
"offsets": [
[
107,
118
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30304 | split_0_train_30304 | [
{
"id": "split_0_train_30304_passage",
"type": "progene_text",
"text": [
"The structures of the ChIL-12 p40 gene and its promoter were determined by direct sequencing of a chicken BAC identified by hybridization with the cDNA ."
],
"offsets": [
[
0,
153
]
]
}
] | [
{
"id": "split_0_train_49030_entity",
"type": "progene_text",
"text": [
"ChIL-12 p40"
],
"offsets": [
[
22,
33
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30305 | split_0_train_30305 | [
{
"id": "split_0_train_30305_passage",
"type": "progene_text",
"text": [
"The gene structures of HuIL-12 , MuIL - 12 , and ChIL-12 p40 all differ ."
],
"offsets": [
[
0,
73
]
]
}
] | [
{
"id": "split_0_train_49031_entity",
"type": "progene_text",
"text": [
"HuIL-12 , MuIL - 12 , and ChIL-12 p40"
],
"offsets": [
[
23,
60
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30306 | split_0_train_30306 | [
{
"id": "split_0_train_30306_passage",
"type": "progene_text",
"text": [
"The promoter of the ChIL-12 p40 gene shares some ( an ETS consensus sequence , a C / EBP binding site , and a TATA box ) but not all ( an NF-kappaB binding site and a GA12 site are absent ) of the transcription factor binding sites identified in the human and murine promoters ."
],
"offsets": [
[
0,
278
]
]
}
] | [
{
"id": "split_0_train_49032_entity",
"type": "progene_text",
"text": [
"ChIL-12 p40"
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"offsets": [
[
20,
31
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],
"normalized": []
},
{
"id": "split_0_train_49033_entity",
"type": "progene_text",
"text": [
"C / EBP"
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"offsets": [
[
81,
88
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],
"normalized": []
},
{
"id": "split_0_train_49034_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
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"offsets": [
[
138,
147
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],
"normalized": []
},
{
"id": "split_0_train_49035_entity",
"type": "progene_text",
"text": [
"transcription factor"
],
"offsets": [
[
197,
217
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30307 | split_0_train_30307 | [
{
"id": "split_0_train_30307_passage",
"type": "progene_text",
"text": [
"IL-12 p40 mRNA expression was identified in a wide variety of tissues and in B , T , and macrophage cell lines by RT - PCR ."
],
"offsets": [
[
0,
124
]
]
}
] | [
{
"id": "split_0_train_49036_entity",
"type": "progene_text",
"text": [
"IL-12 p40"
],
"offsets": [
[
0,
9
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30308 | split_0_train_30308 | [
{
"id": "split_0_train_30308_passage",
"type": "progene_text",
"text": [
"The BAR - domain family of proteins : a case of bending and binding ?"
],
"offsets": [
[
0,
69
]
]
}
] | [
{
"id": "split_0_train_49037_entity",
"type": "progene_text",
"text": [
"BAR - domain family"
],
"offsets": [
[
4,
23
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30309 | split_0_train_30309 | [
{
"id": "split_0_train_30309_passage",
"type": "progene_text",
"text": [
"BAR - domains recently took centre stage in science through a report on the crystal structure of this domain in Drosophila Amphiphysin ."
],
"offsets": [
[
0,
136
]
]
}
] | [
{
"id": "split_0_train_49038_entity",
"type": "progene_text",
"text": [
"Amphiphysin"
],
"offsets": [
[
123,
134
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30310 | split_0_train_30310 | [
{
"id": "split_0_train_30310_passage",
"type": "progene_text",
"text": [
"Though only weakly conserved at the sequence level , the structure of the BAR domain shows striking similarity to the GTPase - binding domain of Arfaptin 2 , an effector of Rho - and Arf - GTPases ."
],
"offsets": [
[
0,
198
]
]
}
] | [
{
"id": "split_0_train_49039_entity",
"type": "progene_text",
"text": [
"GTPase"
],
"offsets": [
[
118,
124
]
],
"normalized": []
},
{
"id": "split_0_train_49040_entity",
"type": "progene_text",
"text": [
"Arfaptin 2"
],
"offsets": [
[
145,
155
]
],
"normalized": []
},
{
"id": "split_0_train_49041_entity",
"type": "progene_text",
"text": [
"Rho"
],
"offsets": [
[
173,
176
]
],
"normalized": []
},
{
"id": "split_0_train_49042_entity",
"type": "progene_text",
"text": [
"Arf - GTPases"
],
"offsets": [
[
183,
196
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30311 | split_0_train_30311 | [
{
"id": "split_0_train_30311_passage",
"type": "progene_text",
"text": [
"On the basis of this sequence and structural similarity , these two proteins have been classified as belonging to the same family , the BAR - domain family , and they probably also have similar functional characteristics ."
],
"offsets": [
[
0,
222
]
]
}
] | [
{
"id": "split_0_train_49043_entity",
"type": "progene_text",
"text": [
"BAR - domain family"
],
"offsets": [
[
136,
155
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30312 | split_0_train_30312 | [
{
"id": "split_0_train_30312_passage",
"type": "progene_text",
"text": [
"Presented here are the results of a database search for the sequence of the BAR domain of Amphiphysin and Arfaptin 2 ."
],
"offsets": [
[
0,
118
]
]
}
] | [
{
"id": "split_0_train_49044_entity",
"type": "progene_text",
"text": [
"Amphiphysin"
],
"offsets": [
[
90,
101
]
],
"normalized": []
},
{
"id": "split_0_train_49045_entity",
"type": "progene_text",
"text": [
"Arfaptin 2"
],
"offsets": [
[
106,
116
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30313 | split_0_train_30313 | [
{
"id": "split_0_train_30313_passage",
"type": "progene_text",
"text": [
"This search identified a variety of related proteins , most of which are involved in intracellular transport and especially in endocytosis ."
],
"offsets": [
[
0,
140
]
]
}
] | [] | [] | [] | [] |
split_0_train_30314 | split_0_train_30314 | [
{
"id": "split_0_train_30314_passage",
"type": "progene_text",
"text": [
"For example , the BAR - domain family includes Endophilins , GTPase - activating proteins of the Centaurinbeta family and Oligophrenins , the adaptor proteins APPL1 and APPL2 that were recently shown to interact with the small GTPase Rab5 , as well as members of the Sorting nexin family ."
],
"offsets": [
[
0,
289
]
]
}
] | [
{
"id": "split_0_train_49046_entity",
"type": "progene_text",
"text": [
"BAR - domain family"
],
"offsets": [
[
18,
37
]
],
"normalized": []
},
{
"id": "split_0_train_49047_entity",
"type": "progene_text",
"text": [
"Endophilins"
],
"offsets": [
[
47,
58
]
],
"normalized": []
},
{
"id": "split_0_train_49048_entity",
"type": "progene_text",
"text": [
"GTPase - activating proteins"
],
"offsets": [
[
61,
89
]
],
"normalized": []
},
{
"id": "split_0_train_49049_entity",
"type": "progene_text",
"text": [
"Centaurinbeta family"
],
"offsets": [
[
97,
117
]
],
"normalized": []
},
{
"id": "split_0_train_49050_entity",
"type": "progene_text",
"text": [
"Oligophrenins"
],
"offsets": [
[
122,
135
]
],
"normalized": []
},
{
"id": "split_0_train_49051_entity",
"type": "progene_text",
"text": [
"adaptor proteins"
],
"offsets": [
[
142,
158
]
],
"normalized": []
},
{
"id": "split_0_train_49052_entity",
"type": "progene_text",
"text": [
"APPL1"
],
"offsets": [
[
159,
164
]
],
"normalized": []
},
{
"id": "split_0_train_49053_entity",
"type": "progene_text",
"text": [
"APPL2"
],
"offsets": [
[
169,
174
]
],
"normalized": []
},
{
"id": "split_0_train_49054_entity",
"type": "progene_text",
"text": [
"small GTPase"
],
"offsets": [
[
221,
233
]
],
"normalized": []
},
{
"id": "split_0_train_49055_entity",
"type": "progene_text",
"text": [
"Rab5"
],
"offsets": [
[
234,
238
]
],
"normalized": []
},
{
"id": "split_0_train_49056_entity",
"type": "progene_text",
"text": [
"Sorting nexin family"
],
"offsets": [
[
267,
287
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30315 | split_0_train_30315 | [
{
"id": "split_0_train_30315_passage",
"type": "progene_text",
"text": [
"On the basis of the structures of Amphiphysin and Arfaptin 2 and the cellular role of Amphiphysins in the early steps of endocytosis , the functions of the BAR domain have been defined as a dimerization motif and as sensing and inducing membrane curvature ."
],
"offsets": [
[
0,
257
]
]
}
] | [
{
"id": "split_0_train_49057_entity",
"type": "progene_text",
"text": [
"Amphiphysin"
],
"offsets": [
[
34,
45
]
],
"normalized": []
},
{
"id": "split_0_train_49058_entity",
"type": "progene_text",
"text": [
"Arfaptin 2"
],
"offsets": [
[
50,
60
]
],
"normalized": []
},
{
"id": "split_0_train_49059_entity",
"type": "progene_text",
"text": [
"Amphiphysins"
],
"offsets": [
[
86,
98
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30316 | split_0_train_30316 | [
{
"id": "split_0_train_30316_passage",
"type": "progene_text",
"text": [
"However , data on Arfaptin 2 and now also on the Adaptor proteins APPL1 and 2 suggest that another function of the BAR domain is to bind to small GTPases ."
],
"offsets": [
[
0,
155
]
]
}
] | [
{
"id": "split_0_train_49060_entity",
"type": "progene_text",
"text": [
"Arfaptin 2"
],
"offsets": [
[
18,
28
]
],
"normalized": []
},
{
"id": "split_0_train_49061_entity",
"type": "progene_text",
"text": [
"Adaptor proteins"
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"offsets": [
[
49,
65
]
],
"normalized": []
},
{
"id": "split_0_train_49062_entity",
"type": "progene_text",
"text": [
"APPL1 and 2"
],
"offsets": [
[
66,
77
]
],
"normalized": []
},
{
"id": "split_0_train_49063_entity",
"type": "progene_text",
"text": [
"small GTPases"
],
"offsets": [
[
140,
153
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30317 | split_0_train_30317 | [
{
"id": "split_0_train_30317_passage",
"type": "progene_text",
"text": [
"Co - expression of three MEP pathway genes and geraniol 10-hydroxylase in internal phloem parenchyma of Catharanthus roseus implicates multicellular translocation of intermediates during the biosynthesis of monoterpene indole alkaloids and isoprenoid - derived primary metabolites ."
],
"offsets": [
[
0,
282
]
]
}
] | [
{
"id": "split_0_train_49064_entity",
"type": "progene_text",
"text": [
"geraniol 10-hydroxylase"
],
"offsets": [
[
47,
70
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30318 | split_0_train_30318 | [
{
"id": "split_0_train_30318_passage",
"type": "progene_text",
"text": [
"In higher plants , isopentenyl diphosphate ( IPP ) is synthesised both from the plastidic 2-C-methyl-d-erythritol 4-phosphate ( MEP ) and from the cytosolic mevalonate ( MVA ) pathways ."
],
"offsets": [
[
0,
186
]
]
}
] | [] | [] | [] | [] |
split_0_train_30319 | split_0_train_30319 | [
{
"id": "split_0_train_30319_passage",
"type": "progene_text",
"text": [
"Primary metabolites , such as phytol group of chlorophylls , carotenoids and the plant hormones abscisic acid ( ABA ) and gibberellins ( GAs ) are derived directly from the MEP pathway ."
],
"offsets": [
[
0,
186
]
]
}
] | [] | [] | [] | [] |
split_0_train_30320 | split_0_train_30320 | [
{
"id": "split_0_train_30320_passage",
"type": "progene_text",
"text": [
"Many secondary metabolites , such as monoterpene indole alkaloids ( MIAs ) in Catharanthus roseus , are also synthesised from this source of IPP ."
],
"offsets": [
[
0,
146
]
]
}
] | [] | [] | [] | [] |
split_0_train_30321 | split_0_train_30321 | [
{
"id": "split_0_train_30321_passage",
"type": "progene_text",
"text": [
"Using Northern blot and in situ hybridisation experiments , we show that three MEP pathway genes ( 1-deoxy-d-xylulose 5-phosphate synthase ( DXS ) , 1-deoxy-d-xylulose 5-phosphate reductoisomerase ( DXR ) and 2C-methyl-d-erythritol 2,4-cyclodiphosphate synthase ( MECS ) ) and the gene encoding geraniol 10-hydroxylase ( G10H ) , a cytochrome P450 monooxygenase involved in the first committed step in the formation of iridoid monoterpenoids display identical cell - specific expression patterns ."
],
"offsets": [
[
0,
497
]
]
}
] | [
{
"id": "split_0_train_49065_entity",
"type": "progene_text",
"text": [
"1-deoxy-d-xylulose 5-phosphate synthase"
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"offsets": [
[
99,
138
]
],
"normalized": []
},
{
"id": "split_0_train_49066_entity",
"type": "progene_text",
"text": [
"DXS"
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"offsets": [
[
141,
144
]
],
"normalized": []
},
{
"id": "split_0_train_49067_entity",
"type": "progene_text",
"text": [
"1-deoxy-d-xylulose 5-phosphate reductoisomerase"
],
"offsets": [
[
149,
196
]
],
"normalized": []
},
{
"id": "split_0_train_49068_entity",
"type": "progene_text",
"text": [
"DXR"
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"offsets": [
[
199,
202
]
],
"normalized": []
},
{
"id": "split_0_train_49069_entity",
"type": "progene_text",
"text": [
"2C-methyl-d-erythritol 2,4-cyclodiphosphate synthase"
],
"offsets": [
[
209,
261
]
],
"normalized": []
},
{
"id": "split_0_train_49070_entity",
"type": "progene_text",
"text": [
"MECS"
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"offsets": [
[
264,
268
]
],
"normalized": []
},
{
"id": "split_0_train_49071_entity",
"type": "progene_text",
"text": [
"geraniol 10-hydroxylase"
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"offsets": [
[
295,
318
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],
"normalized": []
},
{
"id": "split_0_train_49072_entity",
"type": "progene_text",
"text": [
"G10H"
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"offsets": [
[
321,
325
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],
"normalized": []
},
{
"id": "split_0_train_49073_entity",
"type": "progene_text",
"text": [
"cytochrome P450 monooxygenase"
],
"offsets": [
[
332,
361
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30322 | split_0_train_30322 | [
{
"id": "split_0_train_30322_passage",
"type": "progene_text",
"text": [
"The co - localisation of these four transcripts to internal phloem parenchyma of young aerial organs of C. roseus adds a new level of complexity to the multicellular nature of MIA biosynthesis ."
],
"offsets": [
[
0,
194
]
]
}
] | [] | [] | [] | [] |
split_0_train_30323 | split_0_train_30323 | [
{
"id": "split_0_train_30323_passage",
"type": "progene_text",
"text": [
"We predict the translocation of pathway intermediates from the internal phloem parenchyma to the epidermis and , ultimately , to laticifers and idioblasts during MIA biosynthesis ."
],
"offsets": [
[
0,
180
]
]
}
] | [] | [] | [] | [] |
split_0_train_30324 | split_0_train_30324 | [
{
"id": "split_0_train_30324_passage",
"type": "progene_text",
"text": [
"Similarly , the translocation of intermediates from the phloem parenchyma is probably also required during the biosynthesis of hormones and photosynthetic primary metabolites derived from the MEP pathway ."
],
"offsets": [
[
0,
205
]
]
}
] | [] | [] | [] | [] |
split_0_train_30325 | split_0_train_30325 | [
{
"id": "split_0_train_30325_passage",
"type": "progene_text",
"text": [
"Abnormal in vivo metabolism of apoB - containing lipoproteins in human apoE deficiency ."
],
"offsets": [
[
0,
88
]
]
}
] | [
{
"id": "split_0_train_49074_entity",
"type": "progene_text",
"text": [
"apoB"
],
"offsets": [
[
31,
35
]
],
"normalized": []
},
{
"id": "split_0_train_49075_entity",
"type": "progene_text",
"text": [
"apoE"
],
"offsets": [
[
71,
75
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30326 | split_0_train_30326 | [
{
"id": "split_0_train_30326_passage",
"type": "progene_text",
"text": [
"The present study was undertaken to elucidate the metabolic basis for the increased remnants and lipoprotein(a) [ Lp(a) ] and decreased LDL apolipoprotein B ( apoB ) levels in human apoE deficiency ."
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0,
199
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}
] | [
{
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"text": [
"lipoprotein(a)"
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97,
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{
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"type": "progene_text",
"text": [
"Lp(a)"
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114,
119
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{
"id": "split_0_train_49078_entity",
"type": "progene_text",
"text": [
"LDL"
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136,
139
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},
{
"id": "split_0_train_49079_entity",
"type": "progene_text",
"text": [
"apolipoprotein B"
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140,
156
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{
"id": "split_0_train_49080_entity",
"type": "progene_text",
"text": [
"apoB"
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159,
163
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},
{
"id": "split_0_train_49081_entity",
"type": "progene_text",
"text": [
"apoE"
],
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[
182,
186
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30327 | split_0_train_30327 | [
{
"id": "split_0_train_30327_passage",
"type": "progene_text",
"text": [
"A primed constant infusion of (13)C(6)-phenylalanine was administered to a homozygous apoE - deficient subject ."
],
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[
0,
112
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]
}
] | [
{
"id": "split_0_train_49082_entity",
"type": "progene_text",
"text": [
"apoE"
],
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[
86,
90
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30328 | split_0_train_30328 | [
{
"id": "split_0_train_30328_passage",
"type": "progene_text",
"text": [
"apoB-100 and apoB-48 were isolated , and tracer enrichments were determined by gas chromatography - mass spectrometry , then kinetic parameters were calculated by multicompartmental modeling ."
],
"offsets": [
[
0,
192
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]
}
] | [
{
"id": "split_0_train_49083_entity",
"type": "progene_text",
"text": [
"apoB-100"
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0,
8
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{
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"type": "progene_text",
"text": [
"apoB-48"
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[
13,
20
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],
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}
] | [] | [] | [] |
split_0_train_30329 | split_0_train_30329 | [
{
"id": "split_0_train_30329_passage",
"type": "progene_text",
"text": [
"In the apoE - deficient subject , fractional catabolic rates ( FCRs ) of apoB - 100 in VLDL and intermediate density lipoprotein and apoB-48 in VLDL were 3x , 12x , and 12x slower than those of controls ."
],
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0,
204
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]
}
] | [
{
"id": "split_0_train_49085_entity",
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"text": [
"apoE"
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7,
11
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{
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"text": [
"apoB - 100"
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73,
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{
"id": "split_0_train_49087_entity",
"type": "progene_text",
"text": [
"VLDL"
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87,
91
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{
"id": "split_0_train_49088_entity",
"type": "progene_text",
"text": [
"intermediate density lipoprotein"
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96,
128
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{
"id": "split_0_train_49089_entity",
"type": "progene_text",
"text": [
"apoB-48"
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133,
140
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},
{
"id": "split_0_train_49090_entity",
"type": "progene_text",
"text": [
"VLDL"
],
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[
144,
148
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30330 | split_0_train_30330 | [
{
"id": "split_0_train_30330_passage",
"type": "progene_text",
"text": [
"On the other hand , the LDL apoB-100 FCR was increased by 2.6x ."
],
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[
0,
64
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]
}
] | [
{
"id": "split_0_train_49091_entity",
"type": "progene_text",
"text": [
"LDL"
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24,
27
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},
{
"id": "split_0_train_49092_entity",
"type": "progene_text",
"text": [
"apoB-100"
],
"offsets": [
[
28,
36
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30331 | split_0_train_30331 | [
{
"id": "split_0_train_30331_passage",
"type": "progene_text",
"text": [
"The production rate of VLDL apoB-100 was decreased by 45 % ."
],
"offsets": [
[
0,
60
]
]
}
] | [
{
"id": "split_0_train_49093_entity",
"type": "progene_text",
"text": [
"VLDL"
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23,
27
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},
{
"id": "split_0_train_49094_entity",
"type": "progene_text",
"text": [
"apoB-100"
],
"offsets": [
[
28,
36
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30332 | split_0_train_30332 | [
{
"id": "split_0_train_30332_passage",
"type": "progene_text",
"text": [
"In the Lp(a) kinetic study , two types of Lp(a) were isolated from plasma with apoE deficiency : buoyant and normal Lp(a) ."
],
"offsets": [
[
0,
123
]
]
}
] | [
{
"id": "split_0_train_49095_entity",
"type": "progene_text",
"text": [
"Lp(a)"
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7,
12
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],
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},
{
"id": "split_0_train_49096_entity",
"type": "progene_text",
"text": [
"Lp(a)"
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42,
47
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},
{
"id": "split_0_train_49097_entity",
"type": "progene_text",
"text": [
"apoE"
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79,
83
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},
{
"id": "split_0_train_49098_entity",
"type": "progene_text",
"text": [
"Lp(a)"
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"offsets": [
[
116,
121
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30333 | split_0_train_30333 | [
{
"id": "split_0_train_30333_passage",
"type": "progene_text",
"text": [
"(125)I-buoyant Lp(a) was catabolized at a slower rate in the patient ."
],
"offsets": [
[
0,
70
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]
}
] | [
{
"id": "split_0_train_49099_entity",
"type": "progene_text",
"text": [
"Lp(a)"
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"offsets": [
[
15,
20
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30334 | split_0_train_30334 | [
{
"id": "split_0_train_30334_passage",
"type": "progene_text",
"text": [
"However , (125)I-buoyant Lp(a) was catabolized at twice as fast as ( 131 ) I - normal Lp(a) in the control subjects ."
],
"offsets": [
[
0,
117
]
]
}
] | [
{
"id": "split_0_train_49100_entity",
"type": "progene_text",
"text": [
"Lp(a)"
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"offsets": [
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25,
30
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],
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},
{
"id": "split_0_train_49101_entity",
"type": "progene_text",
"text": [
"Lp(a)"
],
"offsets": [
[
86,
91
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30335 | split_0_train_30335 | [
{
"id": "split_0_train_30335_passage",
"type": "progene_text",
"text": [
"In summary , apoE deficiency results in : 1 ) a markedly impaired catabolism of VLDL / chylomicron and their remnants due to lack of direct removal and impaired lipolysis ; 2 ) an increased rate of catabolism of LDL apoB - 100 , likely due to upregulation of LDL receptor activity ; 3 ) reduced VLDL apoB production ; and 4) a delayed catabolism of a portion of Lp(a) ."
],
"offsets": [
[
0,
369
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]
}
] | [
{
"id": "split_0_train_49102_entity",
"type": "progene_text",
"text": [
"apoE"
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13,
17
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},
{
"id": "split_0_train_49103_entity",
"type": "progene_text",
"text": [
"VLDL"
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80,
84
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],
"normalized": []
},
{
"id": "split_0_train_49104_entity",
"type": "progene_text",
"text": [
"chylomicron"
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[
87,
98
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"normalized": []
},
{
"id": "split_0_train_49105_entity",
"type": "progene_text",
"text": [
"LDL"
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212,
215
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],
"normalized": []
},
{
"id": "split_0_train_49106_entity",
"type": "progene_text",
"text": [
"apoB - 100"
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216,
226
]
],
"normalized": []
},
{
"id": "split_0_train_49107_entity",
"type": "progene_text",
"text": [
"LDL receptor"
],
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259,
271
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],
"normalized": []
},
{
"id": "split_0_train_49108_entity",
"type": "progene_text",
"text": [
"VLDL"
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295,
299
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],
"normalized": []
},
{
"id": "split_0_train_49109_entity",
"type": "progene_text",
"text": [
"apoB"
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300,
304
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],
"normalized": []
},
{
"id": "split_0_train_49110_entity",
"type": "progene_text",
"text": [
"Lp(a)"
],
"offsets": [
[
362,
367
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30336 | split_0_train_30336 | [
{
"id": "split_0_train_30336_passage",
"type": "progene_text",
"text": [
"Characterization of B - and T - cell responses and HLA - DR4 binding motifs of the latex allergen Hev b 6.01 ( prohevein ) and its post - transcriptionally formed proteins Hev b 6.02 and Hev b 6.03 ."
],
"offsets": [
[
0,
199
]
]
}
] | [
{
"id": "split_0_train_49111_entity",
"type": "progene_text",
"text": [
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51,
60
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],
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},
{
"id": "split_0_train_49112_entity",
"type": "progene_text",
"text": [
"Hev b 6.01"
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98,
108
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],
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},
{
"id": "split_0_train_49113_entity",
"type": "progene_text",
"text": [
"prohevein"
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111,
120
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},
{
"id": "split_0_train_49114_entity",
"type": "progene_text",
"text": [
"Hev b 6.02"
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172,
182
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},
{
"id": "split_0_train_49115_entity",
"type": "progene_text",
"text": [
"Hev b 6.03"
],
"offsets": [
[
187,
197
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30337 | split_0_train_30337 | [
{
"id": "split_0_train_30337_passage",
"type": "progene_text",
"text": [
"BACKGROUND :"
],
"offsets": [
[
0,
12
]
]
}
] | [] | [] | [] | [] |
split_0_train_30338 | split_0_train_30338 | [
{
"id": "split_0_train_30338_passage",
"type": "progene_text",
"text": [
"Multiple immunoglobulin E ( IgE ) - binding proteins in natural rubber latex extracts have been identified ."
],
"offsets": [
[
0,
108
]
]
}
] | [
{
"id": "split_0_train_49116_entity",
"type": "progene_text",
"text": [
"immunoglobulin E"
],
"offsets": [
[
9,
25
]
],
"normalized": []
},
{
"id": "split_0_train_49117_entity",
"type": "progene_text",
"text": [
"IgE"
],
"offsets": [
[
28,
31
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30339 | split_0_train_30339 | [
{
"id": "split_0_train_30339_passage",
"type": "progene_text",
"text": [
"In the case of Hev b 6 a differentiation was made between the precursor protein prohevein ( Hev b 6.01 ) and its two post - transcriptionally formed proteins , the N - terminal hevein ( Hev b 6.02 ) and the C - terminal domain ( Hev b 6.03 ) ."
],
"offsets": [
[
0,
243
]
]
}
] | [
{
"id": "split_0_train_49118_entity",
"type": "progene_text",
"text": [
"Hev b 6"
],
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[
15,
22
]
],
"normalized": []
},
{
"id": "split_0_train_49119_entity",
"type": "progene_text",
"text": [
"prohevein"
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[
80,
89
]
],
"normalized": []
},
{
"id": "split_0_train_49120_entity",
"type": "progene_text",
"text": [
"Hev b 6.01"
],
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[
92,
102
]
],
"normalized": []
},
{
"id": "split_0_train_49121_entity",
"type": "progene_text",
"text": [
"hevein"
],
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177,
183
]
],
"normalized": []
},
{
"id": "split_0_train_49122_entity",
"type": "progene_text",
"text": [
"Hev b 6.02"
],
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[
186,
196
]
],
"normalized": []
},
{
"id": "split_0_train_49123_entity",
"type": "progene_text",
"text": [
"Hev b 6.03"
],
"offsets": [
[
229,
239
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30340 | split_0_train_30340 | [
{
"id": "split_0_train_30340_passage",
"type": "progene_text",
"text": [
"All three components act as independent allergens ."
],
"offsets": [
[
0,
51
]
]
}
] | [] | [] | [] | [] |
split_0_train_30341 | split_0_train_30341 | [
{
"id": "split_0_train_30341_passage",
"type": "progene_text",
"text": [
"The aim of this study was a detailed analysis of the T-cell responses and the IgE - binding capacity of Hev b 6.01 , Hev b 6.02 and Hev b 6.03 by using these allergens as recombinant maltose - binding fusion ( MBP ) proteins and the usage of synthetic modified hevein peptides ."
],
"offsets": [
[
0,
278
]
]
}
] | [
{
"id": "split_0_train_49124_entity",
"type": "progene_text",
"text": [
"IgE"
],
"offsets": [
[
78,
81
]
],
"normalized": []
},
{
"id": "split_0_train_49125_entity",
"type": "progene_text",
"text": [
"Hev b 6.01"
],
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[
104,
114
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],
"normalized": []
},
{
"id": "split_0_train_49126_entity",
"type": "progene_text",
"text": [
"Hev b 6.02"
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"offsets": [
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117,
127
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],
"normalized": []
},
{
"id": "split_0_train_49127_entity",
"type": "progene_text",
"text": [
"Hev b 6.03"
],
"offsets": [
[
132,
142
]
],
"normalized": []
},
{
"id": "split_0_train_49128_entity",
"type": "progene_text",
"text": [
"MBP"
],
"offsets": [
[
210,
213
]
],
"normalized": []
},
{
"id": "split_0_train_49129_entity",
"type": "progene_text",
"text": [
"hevein"
],
"offsets": [
[
261,
267
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30342 | split_0_train_30342 | [
{
"id": "split_0_train_30342_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
] | [] | [] | [] | [] |
split_0_train_30343 | split_0_train_30343 | [
{
"id": "split_0_train_30343_passage",
"type": "progene_text",
"text": [
"Latex - allergic health care workers ( HCWs ) suffering from rhinitis , conjunctivitis , contact urticaria and / or asthma with increased specific IgE - antibodies to latex were tested for their IgE - binding capacity and T-cell reactivity ( by proliferation response ) to the recombinant MBP - rHev b 6.01 , MBP - rHev b 6.02 , MBP - rHev b 6.03 , to native Hev b 6.02 , to modified hevein peptides and wheat germ agglutinin ( WGA ) ."
],
"offsets": [
[
0,
435
]
]
}
] | [
{
"id": "split_0_train_49130_entity",
"type": "progene_text",
"text": [
"IgE"
],
"offsets": [
[
147,
150
]
],
"normalized": []
},
{
"id": "split_0_train_49131_entity",
"type": "progene_text",
"text": [
"IgE"
],
"offsets": [
[
195,
198
]
],
"normalized": []
},
{
"id": "split_0_train_49132_entity",
"type": "progene_text",
"text": [
"MBP"
],
"offsets": [
[
289,
292
]
],
"normalized": []
},
{
"id": "split_0_train_49133_entity",
"type": "progene_text",
"text": [
"rHev b 6.01"
],
"offsets": [
[
295,
306
]
],
"normalized": []
},
{
"id": "split_0_train_49134_entity",
"type": "progene_text",
"text": [
"MBP"
],
"offsets": [
[
309,
312
]
],
"normalized": []
},
{
"id": "split_0_train_49135_entity",
"type": "progene_text",
"text": [
"rHev b 6.02"
],
"offsets": [
[
315,
326
]
],
"normalized": []
},
{
"id": "split_0_train_49136_entity",
"type": "progene_text",
"text": [
"MBP"
],
"offsets": [
[
329,
332
]
],
"normalized": []
},
{
"id": "split_0_train_49137_entity",
"type": "progene_text",
"text": [
"rHev b 6.03"
],
"offsets": [
[
335,
346
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],
"normalized": []
},
{
"id": "split_0_train_49138_entity",
"type": "progene_text",
"text": [
"Hev b 6.02"
],
"offsets": [
[
359,
369
]
],
"normalized": []
},
{
"id": "split_0_train_49139_entity",
"type": "progene_text",
"text": [
"wheat germ agglutinin"
],
"offsets": [
[
404,
425
]
],
"normalized": []
},
{
"id": "split_0_train_49140_entity",
"type": "progene_text",
"text": [
"WGA"
],
"offsets": [
[
428,
431
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30344 | split_0_train_30344 | [
{
"id": "split_0_train_30344_passage",
"type": "progene_text",
"text": [
"For testing of the human leucocyte antigen ( HLA ) class II restriction of MBP - rHev b 6.01 induced peripheral blood mononuclear cell ( PBMC ) responses , monoclonal antibodies against HLA - DR , HLA - DP or HLA - DQ were added ."
],
"offsets": [
[
0,
230
]
]
}
] | [
{
"id": "split_0_train_49141_entity",
"type": "progene_text",
"text": [
"human leucocyte antigen ( HLA ) class II"
],
"offsets": [
[
19,
59
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],
"normalized": []
},
{
"id": "split_0_train_49142_entity",
"type": "progene_text",
"text": [
"MBP"
],
"offsets": [
[
75,
78
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209,
217
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}
] | [] | [] | [] |
split_0_train_30345 | split_0_train_30345 | [
{
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"type": "progene_text",
"text": [
"RESULTS :"
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0,
9
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}
] | [] | [] | [] | [] |
split_0_train_30346 | split_0_train_30346 | [
{
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"text": [
"Seventeen of 18 ( 94 % ) serum samples from latex - allergic HCWs had increased levels of specific IgE to MBP - rHev b 6.01 , 16 ( 89 % ) to MBP - rHev b 6.02 and 13 ( 72 % ) to MBP - rHev b 6.03 ."
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] | [
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] | [] | [] | [] |
split_0_train_30347 | split_0_train_30347 | [
{
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"text": [
"A significant difference existed between the specific IgE - values of MBP - rHev b 6.02 and MBP - rHev b 6.03 ( P < 0.01 ) ."
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98,
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] | [] | [] | [] |
split_0_train_30348 | split_0_train_30348 | [
{
"id": "split_0_train_30348_passage",
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"text": [
"Proliferation responses of PBMC of the same 18 latex - allergic patients were positive for MBP - rHev b 6.01 and MBP - rHev b 6.03 in 83 and 67 % of the tested PBMC suspension , whereas the proliferation responses induced with MBP - rHev b 6.02 or native Hev b 6.02 were very low ( 5.6 and 22.2 % ) ."
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] | [
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227,
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"text": [
"Hev b 6.02"
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255,
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}
] | [] | [] | [] |
split_0_train_30349 | split_0_train_30349 | [
{
"id": "split_0_train_30349_passage",
"type": "progene_text",
"text": [
"Sera from nine additional latex - allergic patients showed specific IgE binding to the native Hev b 6.02 , but none of these sera showed specific IgE binding to the modified Hev b 6.02 - peptides [ whereby all eight cysteine residues were substituted by serine ( C --> S ) or by alanine ( C --> A ) ] ."
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302
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] | [
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146,
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"text": [
"Hev b 6.02"
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174,
184
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}
] | [] | [] | [] |
split_0_train_30350 | split_0_train_30350 | [
{
"id": "split_0_train_30350_passage",
"type": "progene_text",
"text": [
"Proliferation responses induced by the modified Hev b 6.02 peptides were not significantly different from that induced by Hev b 6.02 ."
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0,
134
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]
}
] | [
{
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"text": [
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48,
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{
"id": "split_0_train_49171_entity",
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"text": [
"Hev b 6.02"
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122,
132
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],
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}
] | [] | [] | [] |
split_0_train_30351 | split_0_train_30351 | [
{
"id": "split_0_train_30351_passage",
"type": "progene_text",
"text": [
"Potential HLA-DR4Dw4 ( DRB1*0401 ) - restricted T-cell epitopes of Hev b 6.01 predicted by two computer algorithms were only found in the Hev b 6.03 - part of Hev b 6.01 ."
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"offsets": [
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0,
171
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]
}
] | [
{
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{
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159,
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}
] | [] | [] | [] |
split_0_train_30352 | split_0_train_30352 | [
{
"id": "split_0_train_30352_passage",
"type": "progene_text",
"text": [
"CONCLUSION :"
],
"offsets": [
[
0,
12
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]
}
] | [] | [] | [] | [] |
split_0_train_30353 | split_0_train_30353 | [
{
"id": "split_0_train_30353_passage",
"type": "progene_text",
"text": [
"In the Hev b 6.01 precursor the regions responsible for IgE binding and those for inducing the T-cell proliferation responses are settled in different parts of the protein ."
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0,
173
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}
] | [
{
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{
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56,
59
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}
] | [] | [] | [] |
split_0_train_30354 | split_0_train_30354 | [
{
"id": "split_0_train_30354_passage",
"type": "progene_text",
"text": [
"The Hev b 6.02 domain is responsible for IgE binding and carries discontinuous B-cell epitopes whereas Hev b 6.03 is a better inducer of a proliferation response and contains HLA-DR4 - binding motifs ."
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0,
201
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}
] | [
{
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{
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175,
182
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}
] | [] | [] | [] |
split_0_train_30355 | split_0_train_30355 | [
{
"id": "split_0_train_30355_passage",
"type": "progene_text",
"text": [
"Interleukin-8 production by THP-1 cells stimulated by Salmonella enterica serovar Typhimurium porins is mediated by AP-1 , NF-kappaB and MAPK pathways ."
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0,
152
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}
] | [
{
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137,
141
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] | [] | [] | [] |
split_0_train_30356 | split_0_train_30356 | [
{
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"type": "progene_text",
"text": [
"Interleukin-8 ( IL-8 ) is released in response to inflammatory stimuli , such as bacterial products ."
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101
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{
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"IL-8"
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16,
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}
] | [] | [] | [] |
split_0_train_30357 | split_0_train_30357 | [
{
"id": "split_0_train_30357_passage",
"type": "progene_text",
"text": [
"Either porins or lipopolysaccharide ( LPS ) stimulated THP-1 cells to release IL-8 after 24 h ."
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0,
95
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}
] | [
{
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78,
82
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}
] | [] | [] | [] |
split_0_train_30358 | split_0_train_30358 | [
{
"id": "split_0_train_30358_passage",
"type": "progene_text",
"text": [
"We have previously reported that stimulation of monocytic cells with Salmonella enterica serovar Typhimurium porins led to the activation of mitogen - activated protein kinase cascades and of protein tyrosine kinases ( PTKs ) ."
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0,
227
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192,
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"PTKs"
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219,
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] | [] | [] | [] |
split_0_train_30359 | split_0_train_30359 | [
{
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"text": [
"In this report , we demonstrate , using two potent and selective inhibitors of MEK activation by Raf-1 ( PD-098059 ) and p38 ( SB-203580 ) , that both ERK1 / 2 and p38 pathways play a key role in the production of IL-8 by porins and LPS ."
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{
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121,
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151,
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164,
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"IL-8"
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214,
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}
] | [] | [] | [] |
split_0_train_30360 | split_0_train_30360 | [
{
"id": "split_0_train_30360_passage",
"type": "progene_text",
"text": [
"Porin - stimulated expression of activating protein 1 ( AP-1 ) and correlated IL-8 release is also inhibited by PD-098059 or SB-203580 indicating that the Raf-1 / MEK1 - MEK2 / MAPK cascade is required for their activation ."
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0,
224
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}
] | [
{
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33,
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{
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56,
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78,
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{
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155,
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{
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163,
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{
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170,
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177,
181
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}
] | [] | [] | [] |
split_0_train_30361 | split_0_train_30361 | [
{
"id": "split_0_train_30361_passage",
"type": "progene_text",
"text": [
"Also PTKs modulate the pathway that control IL-8 gene expression , in fact its expression is abolished by tyrphostin ."
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[
0,
118
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]
}
] | [
{
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"type": "progene_text",
"text": [
"PTKs"
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5,
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{
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"type": "progene_text",
"text": [
"IL-8"
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44,
48
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],
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}
] | [] | [] | [] |
split_0_train_30362 | split_0_train_30362 | [
{
"id": "split_0_train_30362_passage",
"type": "progene_text",
"text": [
"By using N-acetyl-leucinyl-leucinyl-norleucinal-H ( ALLN ) an inhibitor of nuclear factor - kappaB ( NF-kappaB ) activity , we also observed IL-8 release modulation ."
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[
0,
166
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}
] | [
{
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{
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101,
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{
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141,
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],
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}
] | [] | [] | [] |
split_0_train_30363 | split_0_train_30363 | [
{
"id": "split_0_train_30363_passage",
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"text": [
"Our results elucidate some of the molecular mechanisms by which AP-1 and NF-kappaB regulate IL-8 release and open new strategies for the design of specific molecules that will modulate IL-8 effects in various infectious diseases ."
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{
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{
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{
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"IL-8"
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185,
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}
] | [] | [] | [] |
split_0_train_30364 | split_0_train_30364 | [
{
"id": "split_0_train_30364_passage",
"type": "progene_text",
"text": [
"Aquaporins : water channel proteins of the cell membrane ."
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}
] | [
{
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"type": "progene_text",
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{
"id": "split_0_train_49216_entity",
"type": "progene_text",
"text": [
"water channel"
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13,
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30365 | split_0_train_30365 | [
{
"id": "split_0_train_30365_passage",
"type": "progene_text",
"text": [
"Aquaporins ( AQP ) are integral membrane proteins that serve as channels in the transfer of water , and in some cases , small solutes across the membrane ."
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[
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155
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]
}
] | [
{
"id": "split_0_train_49217_entity",
"type": "progene_text",
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{
"id": "split_0_train_49218_entity",
"type": "progene_text",
"text": [
"AQP"
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[
13,
16
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],
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}
] | [] | [] | [] |
split_0_train_30366 | split_0_train_30366 | [
{
"id": "split_0_train_30366_passage",
"type": "progene_text",
"text": [
"They are conserved in bacteria , plants , and animals ."
],
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[
0,
55
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]
}
] | [] | [] | [] | [] |
split_0_train_30367 | split_0_train_30367 | [
{
"id": "split_0_train_30367_passage",
"type": "progene_text",
"text": [
"Structural analyses of the molecules have revealed the presence of a pore in the center of each aquaporin molecule ."
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0,
116
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]
}
] | [
{
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"type": "progene_text",
"text": [
"aquaporin"
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96,
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30368 | split_0_train_30368 | [
{
"id": "split_0_train_30368_passage",
"type": "progene_text",
"text": [
"In mammalian cells , more than 10 isoforms ( AQP0-AQP10 ) have been identified so far ."
],
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}
] | [
{
"id": "split_0_train_49220_entity",
"type": "progene_text",
"text": [
"AQP0-AQP10"
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"offsets": [
[
45,
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30369 | split_0_train_30369 | [
{
"id": "split_0_train_30369_passage",
"type": "progene_text",
"text": [
"They are differentially expressed in many types of cells and tissues in the body ."
],
"offsets": [
[
0,
82
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]
}
] | [] | [] | [] | [] |
split_0_train_30370 | split_0_train_30370 | [
{
"id": "split_0_train_30370_passage",
"type": "progene_text",
"text": [
"AQP0 is abundant in the lens ."
],
"offsets": [
[
0,
30
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]
}
] | [
{
"id": "split_0_train_49221_entity",
"type": "progene_text",
"text": [
"AQP0"
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"offsets": [
[
0,
4
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30371 | split_0_train_30371 | [
{
"id": "split_0_train_30371_passage",
"type": "progene_text",
"text": [
"AQP1 is found in the blood vessels , kidney proximal tubules , eye , and ear ."
],
"offsets": [
[
0,
78
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]
}
] | [
{
"id": "split_0_train_49222_entity",
"type": "progene_text",
"text": [
"AQP1"
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"offsets": [
[
0,
4
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30372 | split_0_train_30372 | [
{
"id": "split_0_train_30372_passage",
"type": "progene_text",
"text": [
"AQP2 is expressed in the kidney collecting ducts , where it shuttles between the intracellular storage sites and the plasma membrane under the control of antidiuretic hormone ( ADH ) ."
],
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[
0,
184
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]
}
] | [
{
"id": "split_0_train_49223_entity",
"type": "progene_text",
"text": [
"AQP2"
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4
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},
{
"id": "split_0_train_49224_entity",
"type": "progene_text",
"text": [
"antidiuretic hormone"
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154,
174
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},
{
"id": "split_0_train_49225_entity",
"type": "progene_text",
"text": [
"ADH"
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"offsets": [
[
177,
180
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30373 | split_0_train_30373 | [
{
"id": "split_0_train_30373_passage",
"type": "progene_text",
"text": [
"Mutations of AQP2 result in diabetes insipidus ."
],
"offsets": [
[
0,
48
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]
}
] | [
{
"id": "split_0_train_49226_entity",
"type": "progene_text",
"text": [
"AQP2"
],
"offsets": [
[
13,
17
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30374 | split_0_train_30374 | [
{
"id": "split_0_train_30374_passage",
"type": "progene_text",
"text": [
"AQP3 is present in the kidney collecting ducts , epidermis , urinary , respiratory , and digestive tracts ."
],
"offsets": [
[
0,
107
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]
}
] | [
{
"id": "split_0_train_49227_entity",
"type": "progene_text",
"text": [
"AQP3"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30375 | split_0_train_30375 | [
{
"id": "split_0_train_30375_passage",
"type": "progene_text",
"text": [
"AQP3 in organs other than the kidney may be involved in the supply of water to them ."
],
"offsets": [
[
0,
85
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]
}
] | [
{
"id": "split_0_train_49228_entity",
"type": "progene_text",
"text": [
"AQP3"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30376 | split_0_train_30376 | [
{
"id": "split_0_train_30376_passage",
"type": "progene_text",
"text": [
"AQP4 is present in the brain astrocytes , eye , ear , skeletal muscle , stomach parietal cells , and kidney collecting ducts ."
],
"offsets": [
[
0,
126
]
]
}
] | [
{
"id": "split_0_train_49229_entity",
"type": "progene_text",
"text": [
"AQP4"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30377 | split_0_train_30377 | [
{
"id": "split_0_train_30377_passage",
"type": "progene_text",
"text": [
"AQP5 is in the secretory cells such as salivary , lacrimal , and sweat glands ."
],
"offsets": [
[
0,
79
]
]
}
] | [
{
"id": "split_0_train_49230_entity",
"type": "progene_text",
"text": [
"AQP5"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30378 | split_0_train_30378 | [
{
"id": "split_0_train_30378_passage",
"type": "progene_text",
"text": [
"AQP5 is also expressed in the ear and eye ."
],
"offsets": [
[
0,
43
]
]
}
] | [
{
"id": "split_0_train_49231_entity",
"type": "progene_text",
"text": [
"AQP5"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30379 | split_0_train_30379 | [
{
"id": "split_0_train_30379_passage",
"type": "progene_text",
"text": [
"AQP6 is localized intracellular vesicles in the kidney collecting duct cells ."
],
"offsets": [
[
0,
78
]
]
}
] | [
{
"id": "split_0_train_49232_entity",
"type": "progene_text",
"text": [
"AQP6"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30380 | split_0_train_30380 | [
{
"id": "split_0_train_30380_passage",
"type": "progene_text",
"text": [
"AQP7 is expressed in the adipocytes , testis , and kidney ."
],
"offsets": [
[
0,
59
]
]
}
] | [
{
"id": "split_0_train_49233_entity",
"type": "progene_text",
"text": [
"AQP7"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30381 | split_0_train_30381 | [
{
"id": "split_0_train_30381_passage",
"type": "progene_text",
"text": [
"AQP8 is expressed in the kidney , testis , and liver ."
],
"offsets": [
[
0,
54
]
]
}
] | [
{
"id": "split_0_train_49234_entity",
"type": "progene_text",
"text": [
"AQP8"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30382 | split_0_train_30382 | [
{
"id": "split_0_train_30382_passage",
"type": "progene_text",
"text": [
"AQP9 is present in the liver and leukocytes ."
],
"offsets": [
[
0,
45
]
]
}
] | [
{
"id": "split_0_train_49235_entity",
"type": "progene_text",
"text": [
"AQP9"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30383 | split_0_train_30383 | [
{
"id": "split_0_train_30383_passage",
"type": "progene_text",
"text": [
"AQP10 is expressed in the intestine ."
],
"offsets": [
[
0,
37
]
]
}
] | [
{
"id": "split_0_train_49236_entity",
"type": "progene_text",
"text": [
"AQP10"
],
"offsets": [
[
0,
5
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30384 | split_0_train_30384 | [
{
"id": "split_0_train_30384_passage",
"type": "progene_text",
"text": [
"The diverse and characteristic distribution of aquaporins in the body suggests their important and specific roles in each organ ."
],
"offsets": [
[
0,
129
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]
}
] | [
{
"id": "split_0_train_49237_entity",
"type": "progene_text",
"text": [
"aquaporins"
],
"offsets": [
[
47,
57
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30385 | split_0_train_30385 | [
{
"id": "split_0_train_30385_passage",
"type": "progene_text",
"text": [
"Apoptotic speck protein - like , a highly homologous protein to apoptotic speck protein in the pyrin domain , is silenced by DNA methylation and induces apoptosis in human hepatocellular carcinoma ."
],
"offsets": [
[
0,
198
]
]
}
] | [
{
"id": "split_0_train_49238_entity",
"type": "progene_text",
"text": [
"Apoptotic speck protein - like"
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30
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{
"id": "split_0_train_49239_entity",
"type": "progene_text",
"text": [
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64,
87
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},
{
"id": "split_0_train_49240_entity",
"type": "progene_text",
"text": [
"pyrin"
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"offsets": [
[
95,
100
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30386 | split_0_train_30386 | [
{
"id": "split_0_train_30386_passage",
"type": "progene_text",
"text": [
"We have identified a novel gene encoding a pyrin domain protein of 89 amino acids that is expressed in various tissues including liver , brain , and spleen ."
],
"offsets": [
[
0,
157
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]
}
] | [
{
"id": "split_0_train_49241_entity",
"type": "progene_text",
"text": [
"pyrin"
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"offsets": [
[
43,
48
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30387 | split_0_train_30387 | [
{
"id": "split_0_train_30387_passage",
"type": "progene_text",
"text": [
"The protein is highly homologous to the pyrin domain of apoptosis - associated speck - like protein ( ASC ) ."
],
"offsets": [
[
0,
109
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]
}
] | [
{
"id": "split_0_train_49242_entity",
"type": "progene_text",
"text": [
"pyrin"
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40,
45
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},
{
"id": "split_0_train_49243_entity",
"type": "progene_text",
"text": [
"apoptosis - associated speck - like protein"
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56,
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},
{
"id": "split_0_train_49244_entity",
"type": "progene_text",
"text": [
"ASC"
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"offsets": [
[
102,
105
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30388 | split_0_train_30388 | [
{
"id": "split_0_train_30388_passage",
"type": "progene_text",
"text": [
"Therefore , we termed it ASC - like ( ASCL ) ."
],
"offsets": [
[
0,
46
]
]
}
] | [
{
"id": "split_0_train_49245_entity",
"type": "progene_text",
"text": [
"ASC - like"
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25,
35
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},
{
"id": "split_0_train_49246_entity",
"type": "progene_text",
"text": [
"ASCL"
],
"offsets": [
[
38,
42
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30389 | split_0_train_30389 | [
{
"id": "split_0_train_30389_passage",
"type": "progene_text",
"text": [
"We found that ASCL gene was densely and frequently ( 80 % ) methylated in hepatocellular carcinoma ( HCC ) cell lines ."
],
"offsets": [
[
0,
119
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]
}
] | [
{
"id": "split_0_train_49247_entity",
"type": "progene_text",
"text": [
"ASCL"
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"offsets": [
[
14,
18
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30390 | split_0_train_30390 | [
{
"id": "split_0_train_30390_passage",
"type": "progene_text",
"text": [
"In contrast , normal liver samples did not show any significant methylation ."
],
"offsets": [
[
0,
77
]
]
}
] | [] | [] | [] | [] |
split_0_train_30391 | split_0_train_30391 | [
{
"id": "split_0_train_30391_passage",
"type": "progene_text",
"text": [
"This aberrant methylation correlated well with the suppression of RNA expression ."
],
"offsets": [
[
0,
82
]
]
}
] | [] | [] | [] | [] |
split_0_train_30392 | split_0_train_30392 | [
{
"id": "split_0_train_30392_passage",
"type": "progene_text",
"text": [
"Furthermore , a demethylating agent , 5-aza-2'-deoxycytidine , reactivated the ASCL expression in the methylation - silenced cells , indicating that ASCL is silenced by the associated DNA methylation ."
],
"offsets": [
[
0,
201
]
]
}
] | [
{
"id": "split_0_train_49248_entity",
"type": "progene_text",
"text": [
"ASCL"
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"offsets": [
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79,
83
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"normalized": []
},
{
"id": "split_0_train_49249_entity",
"type": "progene_text",
"text": [
"ASCL"
],
"offsets": [
[
149,
153
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30393 | split_0_train_30393 | [
{
"id": "split_0_train_30393_passage",
"type": "progene_text",
"text": [
"ASCL methylation was also found in primary HCC ( 4 of 17 samples ) , although the frequency was less than that in cell lines ."
],
"offsets": [
[
0,
126
]
]
}
] | [
{
"id": "split_0_train_49250_entity",
"type": "progene_text",
"text": [
"ASCL"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30394 | split_0_train_30394 | [
{
"id": "split_0_train_30394_passage",
"type": "progene_text",
"text": [
"In addition , we found that ASC was also methylated in primary samples ( 6 of the 17 ) ."
],
"offsets": [
[
0,
88
]
]
}
] | [
{
"id": "split_0_train_49251_entity",
"type": "progene_text",
"text": [
"ASC"
],
"offsets": [
[
28,
31
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30395 | split_0_train_30395 | [
{
"id": "split_0_train_30395_passage",
"type": "progene_text",
"text": [
"Interestingly , either ASCL or ASC methylation was observed in 53 % ( 9 of the 17 ) of primary HCC samples ."
],
"offsets": [
[
0,
108
]
]
}
] | [
{
"id": "split_0_train_49252_entity",
"type": "progene_text",
"text": [
"ASCL"
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"offsets": [
[
23,
27
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],
"normalized": []
},
{
"id": "split_0_train_49253_entity",
"type": "progene_text",
"text": [
"ASC"
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"offsets": [
[
31,
34
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30396 | split_0_train_30396 | [
{
"id": "split_0_train_30396_passage",
"type": "progene_text",
"text": [
"Significantly , the restoration of ASCL in the methylation - silenced cells demonstrated growth suppression in colony formation assay ."
],
"offsets": [
[
0,
135
]
]
}
] | [
{
"id": "split_0_train_49254_entity",
"type": "progene_text",
"text": [
"ASCL"
],
"offsets": [
[
35,
39
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30397 | split_0_train_30397 | [
{
"id": "split_0_train_30397_passage",
"type": "progene_text",
"text": [
"This growth suppression effect of ASCL was supported by apoptotic changes observed in ASCL - transfected cells in which annexin - V binding was positive and caspase-3 was activated ."
],
"offsets": [
[
0,
182
]
]
}
] | [
{
"id": "split_0_train_49255_entity",
"type": "progene_text",
"text": [
"ASCL"
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"offsets": [
[
34,
38
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],
"normalized": []
},
{
"id": "split_0_train_49256_entity",
"type": "progene_text",
"text": [
"ASCL"
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86,
90
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"normalized": []
},
{
"id": "split_0_train_49257_entity",
"type": "progene_text",
"text": [
"annexin - V"
],
"offsets": [
[
120,
131
]
],
"normalized": []
},
{
"id": "split_0_train_49258_entity",
"type": "progene_text",
"text": [
"caspase-3"
],
"offsets": [
[
157,
166
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30398 | split_0_train_30398 | [
{
"id": "split_0_train_30398_passage",
"type": "progene_text",
"text": [
"Based on the methylation - silencing and the growth suppression activity , we propose that ASCL plays a significant role in the development of HCC ."
],
"offsets": [
[
0,
148
]
]
}
] | [
{
"id": "split_0_train_49259_entity",
"type": "progene_text",
"text": [
"ASCL"
],
"offsets": [
[
91,
95
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30399 | split_0_train_30399 | [
{
"id": "split_0_train_30399_passage",
"type": "progene_text",
"text": [
"ErbB4 expression in neural progenitor cells ( ST14A ) is necessary to mediate neuregulin - 1beta1 - induced migration ."
],
"offsets": [
[
0,
119
]
]
}
] | [
{
"id": "split_0_train_49260_entity",
"type": "progene_text",
"text": [
"ErbB4"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "split_0_train_49261_entity",
"type": "progene_text",
"text": [
"neuregulin - 1beta1"
],
"offsets": [
[
78,
97
]
],
"normalized": []
}
] | [] | [] | [] |
Subsets and Splits