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split_0_train_30100 | split_0_train_30100 | [
{
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"text": [
"Although the nature of the signals sensed by MASE1 and MASE2 is still unknown , MASE1 - containing receptors appear to play important roles in bacteria , including iron and/or oxygen sensing by hemerythrine - containing proteins in the sulfate - reducing bacterium Desulfovibrio vulgaris ."
],
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]
}
] | [] | [] | [] | [] |
split_0_train_30101 | split_0_train_30101 | [
{
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"type": "progene_text",
"text": [
"Origin of lipid A species modified with 4-amino-4-deoxy-L-arabinose in polymyxin - resistant mutants of Escherichia coli ."
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122
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]
}
] | [] | [] | [] | [] |
split_0_train_30102 | split_0_train_30102 | [
{
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"type": "progene_text",
"text": [
"An aminotransferase ( ArnB ) that generates UDP-4-deoxyl-L-arabinose ."
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{
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"aminotransferase"
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{
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"text": [
"ArnB"
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22,
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] | [] | [] | [] |
split_0_train_30103 | split_0_train_30103 | [
{
"id": "split_0_train_30103_passage",
"type": "progene_text",
"text": [
"In Escherichia coli and Salmonella typhimurium , addition of the 4-amino-4-deoxy-l-arabinose ( l-Ara4N ) moiety to the phosphate group(s) of lipid A is required for resistance to polymyxin and cationic antimicrobial peptides ."
],
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}
] | [] | [] | [] | [] |
split_0_train_30104 | split_0_train_30104 | [
{
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"type": "progene_text",
"text": [
"We have proposed previously ( Breazeale , S. D. , Ribeiro , A. A. , and Raetz , C. R. H. ( 2002 ) J. Biol. Chem. 277 , 2886 - 2896 ) a pathway for l - Ara4N biosynthesis that begins with the ArnA - catalyzed C-4\" oxidation and C-6 \" decarboxylation of UDP-glucuronic acid , followed by the C-4 \" transamination of the product to generate the novel sugar nucleotide UDP-l-Ara4N ."
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]
}
] | [] | [] | [] | [] |
split_0_train_30105 | split_0_train_30105 | [
{
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"type": "progene_text",
"text": [
"We now show that ArnB ( PmrH ) encodes the relevant aminotransferase ."
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70
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"PmrH"
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{
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"text": [
"aminotransferase"
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52,
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] | [] | [] | [] |
split_0_train_30106 | split_0_train_30106 | [
{
"id": "split_0_train_30106_passage",
"type": "progene_text",
"text": [
"ArnB was overexpressed using a T7lac promoter - driven construct and shown to catalyze the reversible transfer of the amino group from glutamate to the acceptor , uridine 5'-(beta-l-threo-pentapyranosyl-4\"-ulose diphosphate ) , the intermediate that is synthesized by ArnA from UDP-glucuronic acid ."
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{
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"ArnB"
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{
"id": "split_0_train_48717_entity",
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"text": [
"ArnA"
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268,
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}
] | [] | [] | [] |
split_0_train_30107 | split_0_train_30107 | [
{
"id": "split_0_train_30107_passage",
"type": "progene_text",
"text": [
"A 1.7 - mg sample of the putative UDP-l-Ara4N product generated in vitro was purified by ion exchange chromatography , and its structure was confirmed by 1H and 13C NMR spectroscopy ."
],
"offsets": [
[
0,
183
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]
}
] | [] | [] | [] | [] |
split_0_train_30108 | split_0_train_30108 | [
{
"id": "split_0_train_30108_passage",
"type": "progene_text",
"text": [
"ArnB , which is a cytoplasmic protein , was purified to homogeneity from an overproducing strain of E. coli and shown to contain a pyridoxal phosphate cofactor , as judged by ultraviolet / visible spectrophotometry ."
],
"offsets": [
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216
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]
}
] | [
{
"id": "split_0_train_48718_entity",
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"text": [
"ArnB"
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0,
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30109 | split_0_train_30109 | [
{
"id": "split_0_train_30109_passage",
"type": "progene_text",
"text": [
"The pyridoxal phosphate was converted to the pyridoxamine form in the presence of excess glutamate ."
],
"offsets": [
[
0,
100
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]
}
] | [] | [] | [] | [] |
split_0_train_30110 | split_0_train_30110 | [
{
"id": "split_0_train_30110_passage",
"type": "progene_text",
"text": [
"A simple quantitative radiochemical assay was developed for ArnB , which can be used to assay the enzyme either in the forward or the reverse direction ."
],
"offsets": [
[
0,
153
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]
}
] | [
{
"id": "split_0_train_48719_entity",
"type": "progene_text",
"text": [
"ArnB"
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"offsets": [
[
60,
64
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30111 | split_0_train_30111 | [
{
"id": "split_0_train_30111_passage",
"type": "progene_text",
"text": [
"The enzyme is highly selective for glutamate as the amine donor , but the equilibrium constant in the direction of UDP-l-Ara4N formation is unfavorable ( approximately 0.1 ) ."
],
"offsets": [
[
0,
175
]
]
}
] | [] | [] | [] | [] |
split_0_train_30112 | split_0_train_30112 | [
{
"id": "split_0_train_30112_passage",
"type": "progene_text",
"text": [
"ArnB is a member of a very large family of aminotransferases , but closely related ArnB orthologs are present only in those bacteria capable of synthesizing lipid A species modified with the l-Ara4N moiety ."
],
"offsets": [
[
0,
207
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]
}
] | [
{
"id": "split_0_train_48720_entity",
"type": "progene_text",
"text": [
"ArnB"
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4
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{
"id": "split_0_train_48721_entity",
"type": "progene_text",
"text": [
"aminotransferases"
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43,
60
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{
"id": "split_0_train_48722_entity",
"type": "progene_text",
"text": [
"ArnB"
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"offsets": [
[
83,
87
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30113 | split_0_train_30113 | [
{
"id": "split_0_train_30113_passage",
"type": "progene_text",
"text": [
"DNA polymerase zeta : new insight into eukaryotic mutagenesis and mammalian embryonic development ."
],
"offsets": [
[
0,
99
]
]
}
] | [
{
"id": "split_0_train_48723_entity",
"type": "progene_text",
"text": [
"DNA polymerase zeta"
],
"offsets": [
[
0,
19
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30114 | split_0_train_30114 | [
{
"id": "split_0_train_30114_passage",
"type": "progene_text",
"text": [
"Information about the mechanisms that generate mutations in eukaryotes is likely to be useful for understanding human health concerns , such as genotoxicity and cancer ."
],
"offsets": [
[
0,
169
]
]
}
] | [] | [] | [] | [] |
split_0_train_30115 | split_0_train_30115 | [
{
"id": "split_0_train_30115_passage",
"type": "progene_text",
"text": [
"Eukaryotic mutagenesis is largely the outcome of attacks by endogenous and environmental agents ."
],
"offsets": [
[
0,
97
]
]
}
] | [] | [] | [] | [] |
split_0_train_30116 | split_0_train_30116 | [
{
"id": "split_0_train_30116_passage",
"type": "progene_text",
"text": [
"Except for DNA repair , cell cycle checkpoints and DNA damage avoidance , cells have also evolved DNA damage tolerance mechanism , by which lesion - targeted mutation might occur in the genome during replication by specific DNA polymerases to bypass the lesions ( translesion DNA synthesis , TLS ) , or mutation on undamaged DNA templates ( untargeted mutation ) might be induced ."
],
"offsets": [
[
0,
381
]
]
}
] | [
{
"id": "split_0_train_48724_entity",
"type": "progene_text",
"text": [
"DNA polymerases"
],
"offsets": [
[
224,
239
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30117 | split_0_train_30117 | [
{
"id": "split_0_train_30117_passage",
"type": "progene_text",
"text": [
"DNA polymerase zeta ( pol zeta ) , which was found firstly in budding yeast Saccharomyces cerevisiae and consists of catalytic subunit scRev3 and stimulating subunit scRev7 , has received more attention in recent years ."
],
"offsets": [
[
0,
220
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]
}
] | [
{
"id": "split_0_train_48725_entity",
"type": "progene_text",
"text": [
"DNA polymerase zeta"
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{
"id": "split_0_train_48726_entity",
"type": "progene_text",
"text": [
"pol zeta"
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22,
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{
"id": "split_0_train_48727_entity",
"type": "progene_text",
"text": [
"scRev3"
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135,
141
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{
"id": "split_0_train_48728_entity",
"type": "progene_text",
"text": [
"scRev7"
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"offsets": [
[
166,
172
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30118 | split_0_train_30118 | [
{
"id": "split_0_train_30118_passage",
"type": "progene_text",
"text": [
"Pol zeta is a member of DNA polymerase eta subfamily , which belongs to DNA polymerase B family , and exists in almost all eukaryotes ."
],
"offsets": [
[
0,
135
]
]
}
] | [
{
"id": "split_0_train_48729_entity",
"type": "progene_text",
"text": [
"Pol zeta"
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8
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{
"id": "split_0_train_48730_entity",
"type": "progene_text",
"text": [
"DNA polymerase eta subfamily"
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24,
52
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},
{
"id": "split_0_train_48731_entity",
"type": "progene_text",
"text": [
"DNA polymerase B family"
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"offsets": [
[
72,
95
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30119 | split_0_train_30119 | [
{
"id": "split_0_train_30119_passage",
"type": "progene_text",
"text": [
"Human homolog of the scRev3 gene is located in chromosome region 6q21 , and the mouse equivalent maps to chromosome 10 , distal to the c-myb gene and close to the Macs gene ."
],
"offsets": [
[
0,
174
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]
}
] | [
{
"id": "split_0_train_48732_entity",
"type": "progene_text",
"text": [
"scRev3"
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21,
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{
"id": "split_0_train_48733_entity",
"type": "progene_text",
"text": [
"c-myb"
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135,
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{
"id": "split_0_train_48734_entity",
"type": "progene_text",
"text": [
"Macs"
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163,
167
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30120 | split_0_train_30120 | [
{
"id": "split_0_train_30120_passage",
"type": "progene_text",
"text": [
"Alternative splicing , upstream out - of frame ATG can be found in yeast scRev3 , mouse and human homologs ."
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0,
108
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]
}
] | [
{
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"scRev3"
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73,
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],
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}
] | [] | [] | [] |
split_0_train_30121 | split_0_train_30121 | [
{
"id": "split_0_train_30121_passage",
"type": "progene_text",
"text": [
"Furthermore , the sequence from 253 - 323 immediate upstream of the AUG initiator codon has the potential to form a stem - loop hairpin secondary structure in REV3 mRNA , suggesting that human REV3 protein may be expressed at low levels in human cells under normal growth conditions ."
],
"offsets": [
[
0,
284
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]
}
] | [
{
"id": "split_0_train_48736_entity",
"type": "progene_text",
"text": [
"REV3"
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{
"id": "split_0_train_48737_entity",
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"REV3"
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193,
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],
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}
] | [] | [] | [] |
split_0_train_30122 | split_0_train_30122 | [
{
"id": "split_0_train_30122_passage",
"type": "progene_text",
"text": [
"The functional domain analysis showed that yeast Rev3 - 980 tyrosine in conserved region II is at the polymerase active site ."
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0,
126
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]
}
] | [
{
"id": "split_0_train_48738_entity",
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"Rev3"
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{
"id": "split_0_train_48739_entity",
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"text": [
"polymerase"
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102,
112
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],
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}
] | [] | [] | [] |
split_0_train_30123 | split_0_train_30123 | [
{
"id": "split_0_train_30123_passage",
"type": "progene_text",
"text": [
"Human REV3 amino acid residues 1 776 - 2 195 provide a REV7 binding domain , and REV7 amino acid residues 1 - 211 provide a bind domain for REV1 , REV3 and REV7 itself ."
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0,
169
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}
] | [
{
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"REV3"
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{
"id": "split_0_train_48741_entity",
"type": "progene_text",
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"REV7"
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55,
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{
"id": "split_0_train_48742_entity",
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"REV7"
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81,
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{
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"REV1"
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140,
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{
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147,
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{
"id": "split_0_train_48745_entity",
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"REV7"
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156,
160
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30124 | split_0_train_30124 | [
{
"id": "split_0_train_30124_passage",
"type": "progene_text",
"text": [
"More interestingly , REV7 interacts with hMAD2 and therefore might function in the cell cycle control by affecting the activation of APC ( anaphase promoting complex ) ."
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169
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}
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21,
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{
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"APC"
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{
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"type": "progene_text",
"text": [
"anaphase promoting complex"
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139,
165
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30125 | split_0_train_30125 | [
{
"id": "split_0_train_30125_passage",
"type": "progene_text",
"text": [
"Currently it has been known that pol zeta is involved in most spontaneous mutation , lesion - targeted mutation via TLS , chemical carcinogen induced untargeted mutation and somatic hypermutation of antibody genes in mammalian ."
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0,
228
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}
] | [
{
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"pol zeta"
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33,
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}
] | [] | [] | [] |
split_0_train_30126 | split_0_train_30126 | [
{
"id": "split_0_train_30126_passage",
"type": "progene_text",
"text": [
"In TLS pathway , pol zeta acts as a \" mismatch extender \" with combination of other DNA polymerases , such as pol iota ."
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120
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}
] | [
{
"id": "split_0_train_48751_entity",
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"pol iota"
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110,
118
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],
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}
] | [] | [] | [] |
split_0_train_30127 | split_0_train_30127 | [
{
"id": "split_0_train_30127_passage",
"type": "progene_text",
"text": [
"Unlike in yeast , it was found that pol zeta also functioned in mouse embryonic development more recently ."
],
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107
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]
}
] | [
{
"id": "split_0_train_48754_entity",
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"text": [
"pol zeta"
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36,
44
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30128 | split_0_train_30128 | [
{
"id": "split_0_train_30128_passage",
"type": "progene_text",
"text": [
"It was hypothesized that the roles of pol zeta in TLS and cell cycle control might contribute to mouse embryonic lethality ."
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0,
124
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]
}
] | [
{
"id": "split_0_train_48755_entity",
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"pol zeta"
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38,
46
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30129 | split_0_train_30129 | [
{
"id": "split_0_train_30129_passage",
"type": "progene_text",
"text": [
"Glutamine decreases lipopolysaccharide - induced IL-8 production in Caco-2 cells through a non - NF-kappaB p50 mechanism ."
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"offsets": [
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122
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]
}
] | [
{
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{
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97,
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}
] | [] | [] | [] |
split_0_train_30130 | split_0_train_30130 | [
{
"id": "split_0_train_30130_passage",
"type": "progene_text",
"text": [
"Glutamine ( Gln ) supplementation has been shown to decrease production of pro - inflammatory cytokines by the human intestinal mucosa ."
],
"offsets": [
[
0,
136
]
]
}
] | [
{
"id": "split_0_train_48758_entity",
"type": "progene_text",
"text": [
"cytokines"
],
"offsets": [
[
94,
103
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30131 | split_0_train_30131 | [
{
"id": "split_0_train_30131_passage",
"type": "progene_text",
"text": [
"The mechanism of this is poorly understood ."
],
"offsets": [
[
0,
44
]
]
}
] | [] | [] | [] | [] |
split_0_train_30132 | split_0_train_30132 | [
{
"id": "split_0_train_30132_passage",
"type": "progene_text",
"text": [
"We hypothesize that Gln down - regulates lipopolysaccharide ( LPS ) - stimulated pro - inflammatory cytokine production in Caco-2 cells by nuclear factor - kappa B ( NF-kappaB ) ."
],
"offsets": [
[
0,
179
]
]
}
] | [
{
"id": "split_0_train_48759_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
100,
108
]
],
"normalized": []
},
{
"id": "split_0_train_48760_entity",
"type": "progene_text",
"text": [
"nuclear factor - kappa B"
],
"offsets": [
[
139,
163
]
],
"normalized": []
},
{
"id": "split_0_train_48761_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
166,
175
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30133 | split_0_train_30133 | [
{
"id": "split_0_train_30133_passage",
"type": "progene_text",
"text": [
"Caco-2 cells were incubated with different concentrations of Gln with or without methionine sulfoximine ( MS , an inhibitor of glutamine synthetase ) before stimulation with LPS ."
],
"offsets": [
[
0,
179
]
]
}
] | [
{
"id": "split_0_train_48762_entity",
"type": "progene_text",
"text": [
"glutamine synthetase"
],
"offsets": [
[
127,
147
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30134 | split_0_train_30134 | [
{
"id": "split_0_train_30134_passage",
"type": "progene_text",
"text": [
"IL-6 , IL-8 , IL-10 and TNF-alpha protein and mRNA level were determined ."
],
"offsets": [
[
0,
74
]
]
}
] | [
{
"id": "split_0_train_48763_entity",
"type": "progene_text",
"text": [
"IL-6"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_48764_entity",
"type": "progene_text",
"text": [
"IL-8"
],
"offsets": [
[
7,
11
]
],
"normalized": []
},
{
"id": "split_0_train_48765_entity",
"type": "progene_text",
"text": [
"IL-10"
],
"offsets": [
[
14,
19
]
],
"normalized": []
},
{
"id": "split_0_train_48766_entity",
"type": "progene_text",
"text": [
"TNF-alpha"
],
"offsets": [
[
24,
33
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30135 | split_0_train_30135 | [
{
"id": "split_0_train_30135_passage",
"type": "progene_text",
"text": [
"NF-kappaB translocation was determined using an ELISA - based kit ."
],
"offsets": [
[
0,
67
]
]
}
] | [
{
"id": "split_0_train_48767_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
0,
9
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30136 | split_0_train_30136 | [
{
"id": "split_0_train_30136_passage",
"type": "progene_text",
"text": [
"IL-8 was the only detectable cytokine / chemokine ."
],
"offsets": [
[
0,
51
]
]
}
] | [
{
"id": "split_0_train_48768_entity",
"type": "progene_text",
"text": [
"IL-8"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_48769_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
29,
37
]
],
"normalized": []
},
{
"id": "split_0_train_48770_entity",
"type": "progene_text",
"text": [
"chemokine"
],
"offsets": [
[
40,
49
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30137 | split_0_train_30137 | [
{
"id": "split_0_train_30137_passage",
"type": "progene_text",
"text": [
"The largest amount of IL-8 was secreted by cells in the presence of MS with no Gln in the medium after exposure to LPS ."
],
"offsets": [
[
0,
120
]
]
}
] | [
{
"id": "split_0_train_48771_entity",
"type": "progene_text",
"text": [
"IL-8"
],
"offsets": [
[
22,
26
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30138 | split_0_train_30138 | [
{
"id": "split_0_train_30138_passage",
"type": "progene_text",
"text": [
"LPS increased IL-8 production , peaking 10h after LPS administration ."
],
"offsets": [
[
0,
70
]
]
}
] | [
{
"id": "split_0_train_48772_entity",
"type": "progene_text",
"text": [
"IL-8"
],
"offsets": [
[
14,
18
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30139 | split_0_train_30139 | [
{
"id": "split_0_train_30139_passage",
"type": "progene_text",
"text": [
"The addition of Gln ( 0.5 or 5.0mM ) decreased IL-8 peptide and mRNA expression ."
],
"offsets": [
[
0,
81
]
]
}
] | [
{
"id": "split_0_train_48773_entity",
"type": "progene_text",
"text": [
"IL-8"
],
"offsets": [
[
47,
51
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30140 | split_0_train_30140 | [
{
"id": "split_0_train_30140_passage",
"type": "progene_text",
"text": [
"LPS increased NF-kappaB nuclear translocation in the presence or absence of MS ."
],
"offsets": [
[
0,
80
]
]
}
] | [
{
"id": "split_0_train_48774_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
14,
23
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30141 | split_0_train_30141 | [
{
"id": "split_0_train_30141_passage",
"type": "progene_text",
"text": [
"Neither Gln nor MS altered NF-kappaB nuclear translocation ."
],
"offsets": [
[
0,
60
]
]
}
] | [
{
"id": "split_0_train_48775_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
27,
36
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30142 | split_0_train_30142 | [
{
"id": "split_0_train_30142_passage",
"type": "progene_text",
"text": [
"These results indicate that the lack of glutamine increases IL-8 production by Caco-2 cells after LPS stimulation ."
],
"offsets": [
[
0,
115
]
]
}
] | [
{
"id": "split_0_train_48776_entity",
"type": "progene_text",
"text": [
"IL-8"
],
"offsets": [
[
60,
64
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30143 | split_0_train_30143 | [
{
"id": "split_0_train_30143_passage",
"type": "progene_text",
"text": [
"However , the glutamine - mediated decrease in LPS - stimulated IL-8 production is not associated with NF-kappaB p50 nuclear binding ."
],
"offsets": [
[
0,
134
]
]
}
] | [
{
"id": "split_0_train_48777_entity",
"type": "progene_text",
"text": [
"IL-8"
],
"offsets": [
[
64,
68
]
],
"normalized": []
},
{
"id": "split_0_train_48778_entity",
"type": "progene_text",
"text": [
"NF-kappaB p50"
],
"offsets": [
[
103,
116
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30144 | split_0_train_30144 | [
{
"id": "split_0_train_30144_passage",
"type": "progene_text",
"text": [
"[ Construction and stable expression of intracellular antibodies to glycoprotein of hantavirus ]"
],
"offsets": [
[
0,
96
]
]
}
] | [] | [] | [] | [] |
split_0_train_30145 | split_0_train_30145 | [
{
"id": "split_0_train_30145_passage",
"type": "progene_text",
"text": [
"OBJECTIVE :"
],
"offsets": [
[
0,
11
]
]
}
] | [] | [] | [] | [] |
split_0_train_30146 | split_0_train_30146 | [
{
"id": "split_0_train_30146_passage",
"type": "progene_text",
"text": [
"To understand the molecular mechanisms of hantavirus assembly and maturation by stably expressing the intracellular antibodies to hantavirus glycoprotein G1 and G2 in endoplasmic reticulum ( ER ) and cytoplasm ( Cyto ) of Vero E6 cell ."
],
"offsets": [
[
0,
236
]
]
}
] | [
{
"id": "split_0_train_48779_entity",
"type": "progene_text",
"text": [
"glycoprotein G1 and G2"
],
"offsets": [
[
141,
163
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30147 | split_0_train_30147 | [
{
"id": "split_0_train_30147_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
] | [] | [] | [] | [] |
split_0_train_30148 | split_0_train_30148 | [
{
"id": "split_0_train_30148_passage",
"type": "progene_text",
"text": [
"The genes of VH and VL of antibodies against glycoprotein of hantavirus were amplified by PCR and cloned into pOPE 101 - 215 ( Yol ) vector ."
],
"offsets": [
[
0,
141
]
]
}
] | [] | [] | [] | [] |
split_0_train_30149 | split_0_train_30149 | [
{
"id": "split_0_train_30149_passage",
"type": "progene_text",
"text": [
"The G1 and G2 proteins specific ScFv genes were first expressed in E.coli and the function and binding properties were identified ."
],
"offsets": [
[
0,
131
]
]
}
] | [
{
"id": "split_0_train_48780_entity",
"type": "progene_text",
"text": [
"G1"
],
"offsets": [
[
4,
6
]
],
"normalized": []
},
{
"id": "split_0_train_48781_entity",
"type": "progene_text",
"text": [
"G2"
],
"offsets": [
[
11,
13
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30150 | split_0_train_30150 | [
{
"id": "split_0_train_30150_passage",
"type": "progene_text",
"text": [
"The gene of ScFv were further inserted into intracellular expression vectyrs pEF / myc / ER and pEF / myc / CYTO vector and transfected Vero E6 cell ."
],
"offsets": [
[
0,
150
]
]
}
] | [
{
"id": "split_0_train_48782_entity",
"type": "progene_text",
"text": [
"myc"
],
"offsets": [
[
83,
86
]
],
"normalized": []
},
{
"id": "split_0_train_48783_entity",
"type": "progene_text",
"text": [
"myc"
],
"offsets": [
[
102,
105
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30151 | split_0_train_30151 | [
{
"id": "split_0_train_30151_passage",
"type": "progene_text",
"text": [
"The clonal cell line which stabl expresses ScFv were isolated under the pressure of G418 ."
],
"offsets": [
[
0,
90
]
]
}
] | [] | [] | [] | [] |
split_0_train_30152 | split_0_train_30152 | [
{
"id": "split_0_train_30152_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
] | [] | [] | [] | [] |
split_0_train_30153 | split_0_train_30153 | [
{
"id": "split_0_train_30153_passage",
"type": "progene_text",
"text": [
"The ScFv genes of hantavirus G1 and G2 specific antibodies were successfully expressed in subcellular compartment ER and Cyto of Vero E6 cells and specifically targeted G1 and G2 protein after virus infection of the cells ."
],
"offsets": [
[
0,
223
]
]
}
] | [
{
"id": "split_0_train_48784_entity",
"type": "progene_text",
"text": [
"G1"
],
"offsets": [
[
29,
31
]
],
"normalized": []
},
{
"id": "split_0_train_48785_entity",
"type": "progene_text",
"text": [
"G2"
],
"offsets": [
[
36,
38
]
],
"normalized": []
},
{
"id": "split_0_train_48786_entity",
"type": "progene_text",
"text": [
"G1"
],
"offsets": [
[
169,
171
]
],
"normalized": []
},
{
"id": "split_0_train_48787_entity",
"type": "progene_text",
"text": [
"G2"
],
"offsets": [
[
176,
178
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30154 | split_0_train_30154 | [
{
"id": "split_0_train_30154_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
] | [] | [] | [] | [] |
split_0_train_30155 | split_0_train_30155 | [
{
"id": "split_0_train_30155_passage",
"type": "progene_text",
"text": [
"The recombination of intrabody to Hantann virus glycoprotein was constructed successfully , and it may provide basic material for the studying antiviral gene therapy and the molecular mechanism of viral replication and infection ."
],
"offsets": [
[
0,
230
]
]
}
] | [] | [] | [] | [] |
split_0_train_30156 | split_0_train_30156 | [
{
"id": "split_0_train_30156_passage",
"type": "progene_text",
"text": [
"Regulation of sialic acid catabolism by the DNA binding protein NanR in Escherichia coli ."
],
"offsets": [
[
0,
90
]
]
}
] | [
{
"id": "split_0_train_48788_entity",
"type": "progene_text",
"text": [
"NanR"
],
"offsets": [
[
64,
68
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30157 | split_0_train_30157 | [
{
"id": "split_0_train_30157_passage",
"type": "progene_text",
"text": [
"All Escherichia coli strains so far examined possess a chromosomally encoded nanATEK - yhcH operon for the catabolism of sialic acids ."
],
"offsets": [
[
0,
135
]
]
}
] | [
{
"id": "split_0_train_48789_entity",
"type": "progene_text",
"text": [
"nanATEK"
],
"offsets": [
[
77,
84
]
],
"normalized": []
},
{
"id": "split_0_train_48790_entity",
"type": "progene_text",
"text": [
"yhcH"
],
"offsets": [
[
87,
91
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30158 | split_0_train_30158 | [
{
"id": "split_0_train_30158_passage",
"type": "progene_text",
"text": [
"These unique nine - carbon sugars are synthesized primarily by higher eukaryotes and can be used as carbon , nitrogen , and energy sources by a variety of microbial pathogens or commensals ."
],
"offsets": [
[
0,
190
]
]
}
] | [] | [] | [] | [] |
split_0_train_30159 | split_0_train_30159 | [
{
"id": "split_0_train_30159_passage",
"type": "progene_text",
"text": [
"The gene nanR , located immediately upstream of the operon , encodes a protein of the FadR / GntR family that represses nan expression in trans ."
],
"offsets": [
[
0,
145
]
]
}
] | [
{
"id": "split_0_train_48791_entity",
"type": "progene_text",
"text": [
"nanR"
],
"offsets": [
[
9,
13
]
],
"normalized": []
},
{
"id": "split_0_train_48792_entity",
"type": "progene_text",
"text": [
"FadR / GntR family"
],
"offsets": [
[
86,
104
]
],
"normalized": []
},
{
"id": "split_0_train_48793_entity",
"type": "progene_text",
"text": [
"nan"
],
"offsets": [
[
120,
123
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30160 | split_0_train_30160 | [
{
"id": "split_0_train_30160_passage",
"type": "progene_text",
"text": [
"S1 analysis identified the nan transcriptional start , and DNA footprint analysis showed that NanR binds to a region of approximately 30 bp covering the promoter region ."
],
"offsets": [
[
0,
170
]
]
}
] | [
{
"id": "split_0_train_48794_entity",
"type": "progene_text",
"text": [
"nan"
],
"offsets": [
[
27,
30
]
],
"normalized": []
},
{
"id": "split_0_train_48795_entity",
"type": "progene_text",
"text": [
"NanR"
],
"offsets": [
[
94,
98
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30161 | split_0_train_30161 | [
{
"id": "split_0_train_30161_passage",
"type": "progene_text",
"text": [
"Native ( nondenaturing ) polyacrylamide gel electrophoresis , mass spectrometry , and chemical cross - linking indicated that NanR forms homodimers in solution ."
],
"offsets": [
[
0,
161
]
]
}
] | [
{
"id": "split_0_train_48796_entity",
"type": "progene_text",
"text": [
"NanR"
],
"offsets": [
[
126,
130
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30162 | split_0_train_30162 | [
{
"id": "split_0_train_30162_passage",
"type": "progene_text",
"text": [
"The region protected by NanR contains three tandem repeats of the hexameric sequence GGTATA ."
],
"offsets": [
[
0,
93
]
]
}
] | [
{
"id": "split_0_train_48797_entity",
"type": "progene_text",
"text": [
"NanR"
],
"offsets": [
[
24,
28
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30163 | split_0_train_30163 | [
{
"id": "split_0_train_30163_passage",
"type": "progene_text",
"text": [
"Gel shift analysis with purified hexahistidine - tagged or native NanR detected three retarded complexes , suggesting that NanR binds sequentially to the three repeats ."
],
"offsets": [
[
0,
169
]
]
}
] | [
{
"id": "split_0_train_48798_entity",
"type": "progene_text",
"text": [
"NanR"
],
"offsets": [
[
66,
70
]
],
"normalized": []
},
{
"id": "split_0_train_48799_entity",
"type": "progene_text",
"text": [
"NanR"
],
"offsets": [
[
123,
127
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30164 | split_0_train_30164 | [
{
"id": "split_0_train_30164_passage",
"type": "progene_text",
"text": [
"Artificial operators carrying different numbers of repeats formed the corresponding number of complexes ."
],
"offsets": [
[
0,
105
]
]
}
] | [] | [] | [] | [] |
split_0_train_30165 | split_0_train_30165 | [
{
"id": "split_0_train_30165_passage",
"type": "progene_text",
"text": [
"Among the sugars tested that were predicted to be products of the nan - encoded system , only the exogenous addition of sialic acid resulted in the dramatic induction of a chromosomal nanA - lacZ fusion or displaced NanR from its operator in vitro ."
],
"offsets": [
[
0,
249
]
]
}
] | [
{
"id": "split_0_train_48800_entity",
"type": "progene_text",
"text": [
"nan"
],
"offsets": [
[
66,
69
]
],
"normalized": []
},
{
"id": "split_0_train_48801_entity",
"type": "progene_text",
"text": [
"nanA"
],
"offsets": [
[
184,
188
]
],
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},
{
"id": "split_0_train_48802_entity",
"type": "progene_text",
"text": [
"lacZ"
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[
191,
195
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],
"normalized": []
},
{
"id": "split_0_train_48803_entity",
"type": "progene_text",
"text": [
"NanR"
],
"offsets": [
[
216,
220
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30166 | split_0_train_30166 | [
{
"id": "split_0_train_30166_passage",
"type": "progene_text",
"text": [
"Titration of NanR by the nan promoter region or artificial operators carrying different numbers of the GGTATA repeat on plasmids in this fusion strain supported the binding of the regulator to target DNA in vivo ."
],
"offsets": [
[
0,
213
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]
}
] | [
{
"id": "split_0_train_48804_entity",
"type": "progene_text",
"text": [
"NanR"
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13,
17
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],
"normalized": []
},
{
"id": "split_0_train_48805_entity",
"type": "progene_text",
"text": [
"nan"
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"offsets": [
[
25,
28
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30167 | split_0_train_30167 | [
{
"id": "split_0_train_30167_passage",
"type": "progene_text",
"text": [
"Together , the results indicate that GGTATA is important for NanR binding , but the precise mechanism remains to be determined ."
],
"offsets": [
[
0,
128
]
]
}
] | [
{
"id": "split_0_train_48806_entity",
"type": "progene_text",
"text": [
"NanR"
],
"offsets": [
[
61,
65
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30168 | split_0_train_30168 | [
{
"id": "split_0_train_30168_passage",
"type": "progene_text",
"text": [
"GadE ( YhiE ) activates glutamate decarboxylase - dependent acid resistance in Escherichia coli K-12 ."
],
"offsets": [
[
0,
102
]
]
}
] | [
{
"id": "split_0_train_48807_entity",
"type": "progene_text",
"text": [
"GadE"
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"offsets": [
[
0,
4
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],
"normalized": []
},
{
"id": "split_0_train_48808_entity",
"type": "progene_text",
"text": [
"YhiE"
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"offsets": [
[
7,
11
]
],
"normalized": []
},
{
"id": "split_0_train_48809_entity",
"type": "progene_text",
"text": [
"glutamate decarboxylase"
],
"offsets": [
[
24,
47
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30169 | split_0_train_30169 | [
{
"id": "split_0_train_30169_passage",
"type": "progene_text",
"text": [
"Commensal and pathogenic strains of Escherichia coli possess three inducible acid resistance systems that collaboratively protect cells against acid stress to pH 2 or below ."
],
"offsets": [
[
0,
174
]
]
}
] | [] | [] | [] | [] |
split_0_train_30170 | split_0_train_30170 | [
{
"id": "split_0_train_30170_passage",
"type": "progene_text",
"text": [
"The most effective system requires glutamate in the acid challenge media and relies on two glutamate decarboxylases ( GadA and B ) combined with a putative glutamate : gamma-aminobutyric acid antiporter ( GadC ) ."
],
"offsets": [
[
0,
213
]
]
}
] | [
{
"id": "split_0_train_48810_entity",
"type": "progene_text",
"text": [
"glutamate decarboxylases"
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[
91,
115
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],
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},
{
"id": "split_0_train_48811_entity",
"type": "progene_text",
"text": [
"GadA and B"
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[
118,
128
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],
"normalized": []
},
{
"id": "split_0_train_48812_entity",
"type": "progene_text",
"text": [
"glutamate : gamma-aminobutyric acid antiporter"
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[
156,
202
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],
"normalized": []
},
{
"id": "split_0_train_48813_entity",
"type": "progene_text",
"text": [
"GadC"
],
"offsets": [
[
205,
209
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30171 | split_0_train_30171 | [
{
"id": "split_0_train_30171_passage",
"type": "progene_text",
"text": [
"A complex network of regulators mediates induction of this system in response to various media , pH and growth phase signals ."
],
"offsets": [
[
0,
126
]
]
}
] | [] | [] | [] | [] |
split_0_train_30172 | split_0_train_30172 | [
{
"id": "split_0_train_30172_passage",
"type": "progene_text",
"text": [
"We report that the LuxR - like regulator GadE ( formerly YhiE ) is required for expression of gadA and gadBC regardless of media or growth conditions ."
],
"offsets": [
[
0,
151
]
]
}
] | [
{
"id": "split_0_train_48814_entity",
"type": "progene_text",
"text": [
"LuxR"
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[
19,
23
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],
"normalized": []
},
{
"id": "split_0_train_48815_entity",
"type": "progene_text",
"text": [
"GadE"
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[
41,
45
]
],
"normalized": []
},
{
"id": "split_0_train_48816_entity",
"type": "progene_text",
"text": [
"YhiE"
],
"offsets": [
[
57,
61
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],
"normalized": []
},
{
"id": "split_0_train_48817_entity",
"type": "progene_text",
"text": [
"gadA"
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[
94,
98
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],
"normalized": []
},
{
"id": "split_0_train_48818_entity",
"type": "progene_text",
"text": [
"gadBC"
],
"offsets": [
[
103,
108
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30173 | split_0_train_30173 | [
{
"id": "split_0_train_30173_passage",
"type": "progene_text",
"text": [
"This protein binds directly to the 20 bp GAD box sequence found in the control regions of both loci ."
],
"offsets": [
[
0,
101
]
]
}
] | [
{
"id": "split_0_train_48819_entity",
"type": "progene_text",
"text": [
"GAD"
],
"offsets": [
[
41,
44
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30174 | split_0_train_30174 | [
{
"id": "split_0_train_30174_passage",
"type": "progene_text",
"text": [
"Two previously identified AraC - like regulators , GadX and GadW , are only needed for gadA / BC expression under some circumstances ."
],
"offsets": [
[
0,
134
]
]
}
] | [
{
"id": "split_0_train_48820_entity",
"type": "progene_text",
"text": [
"AraC"
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[
26,
30
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],
"normalized": []
},
{
"id": "split_0_train_48821_entity",
"type": "progene_text",
"text": [
"GadX"
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[
51,
55
]
],
"normalized": []
},
{
"id": "split_0_train_48822_entity",
"type": "progene_text",
"text": [
"GadW"
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"offsets": [
[
60,
64
]
],
"normalized": []
},
{
"id": "split_0_train_48823_entity",
"type": "progene_text",
"text": [
"gadA / BC"
],
"offsets": [
[
87,
96
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30175 | split_0_train_30175 | [
{
"id": "split_0_train_30175_passage",
"type": "progene_text",
"text": [
"Overexpression of GadX or GadW will not overcome a need for GadE ."
],
"offsets": [
[
0,
66
]
]
}
] | [
{
"id": "split_0_train_48824_entity",
"type": "progene_text",
"text": [
"GadX"
],
"offsets": [
[
18,
22
]
],
"normalized": []
},
{
"id": "split_0_train_48825_entity",
"type": "progene_text",
"text": [
"GadW"
],
"offsets": [
[
26,
30
]
],
"normalized": []
},
{
"id": "split_0_train_48826_entity",
"type": "progene_text",
"text": [
"GadE"
],
"offsets": [
[
60,
64
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30176 | split_0_train_30176 | [
{
"id": "split_0_train_30176_passage",
"type": "progene_text",
"text": [
"However , overexpression of GadE can supplant a requirement for GadX and W ."
],
"offsets": [
[
0,
76
]
]
}
] | [
{
"id": "split_0_train_48827_entity",
"type": "progene_text",
"text": [
"GadE"
],
"offsets": [
[
28,
32
]
],
"normalized": []
},
{
"id": "split_0_train_48828_entity",
"type": "progene_text",
"text": [
"GadX and W"
],
"offsets": [
[
64,
74
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30177 | split_0_train_30177 | [
{
"id": "split_0_train_30177_passage",
"type": "progene_text",
"text": [
"Data provided also indicate that GadX and GadE can simultaneously bind the area around the GAD box region and probably form a complex ."
],
"offsets": [
[
0,
135
]
]
}
] | [
{
"id": "split_0_train_48829_entity",
"type": "progene_text",
"text": [
"GadX"
],
"offsets": [
[
33,
37
]
],
"normalized": []
},
{
"id": "split_0_train_48830_entity",
"type": "progene_text",
"text": [
"GadE"
],
"offsets": [
[
42,
46
]
],
"normalized": []
},
{
"id": "split_0_train_48831_entity",
"type": "progene_text",
"text": [
"GAD"
],
"offsets": [
[
91,
94
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30178 | split_0_train_30178 | [
{
"id": "split_0_train_30178_passage",
"type": "progene_text",
"text": [
"The gadA , gadBC and gadE genes are all induced by low pH in exponential phase cells grown in minimal glucose media ."
],
"offsets": [
[
0,
117
]
]
}
] | [
{
"id": "split_0_train_48832_entity",
"type": "progene_text",
"text": [
"gadA"
],
"offsets": [
[
4,
8
]
],
"normalized": []
},
{
"id": "split_0_train_48833_entity",
"type": "progene_text",
"text": [
"gadBC"
],
"offsets": [
[
11,
16
]
],
"normalized": []
},
{
"id": "split_0_train_48834_entity",
"type": "progene_text",
"text": [
"gadE"
],
"offsets": [
[
21,
25
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30179 | split_0_train_30179 | [
{
"id": "split_0_train_30179_passage",
"type": "progene_text",
"text": [
"The acid induction of gadA / BC results primarily from the acid induction of gadE ."
],
"offsets": [
[
0,
83
]
]
}
] | [
{
"id": "split_0_train_48835_entity",
"type": "progene_text",
"text": [
"gadA / BC"
],
"offsets": [
[
22,
31
]
],
"normalized": []
},
{
"id": "split_0_train_48836_entity",
"type": "progene_text",
"text": [
"gadE"
],
"offsets": [
[
77,
81
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30180 | split_0_train_30180 | [
{
"id": "split_0_train_30180_passage",
"type": "progene_text",
"text": [
"Constitutive expression of GadE removes most pH control over the glutamate decarboxylase and antiporter genes ."
],
"offsets": [
[
0,
111
]
]
}
] | [
{
"id": "split_0_train_48837_entity",
"type": "progene_text",
"text": [
"GadE"
],
"offsets": [
[
27,
31
]
],
"normalized": []
},
{
"id": "split_0_train_48838_entity",
"type": "progene_text",
"text": [
"glutamate decarboxylase"
],
"offsets": [
[
65,
88
]
],
"normalized": []
},
{
"id": "split_0_train_48839_entity",
"type": "progene_text",
"text": [
"antiporter"
],
"offsets": [
[
93,
103
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30181 | split_0_train_30181 | [
{
"id": "split_0_train_30181_passage",
"type": "progene_text",
"text": [
"The small amount of remaining pH control is governed by GadX and W ."
],
"offsets": [
[
0,
68
]
]
}
] | [
{
"id": "split_0_train_48840_entity",
"type": "progene_text",
"text": [
"GadX and W"
],
"offsets": [
[
56,
66
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30182 | split_0_train_30182 | [
{
"id": "split_0_train_30182_passage",
"type": "progene_text",
"text": [
"The finding that gadE mutations also diminish the effectiveness of the other two acid resistance systems suggests that GadE influences the expression of additional acid resistance components ."
],
"offsets": [
[
0,
192
]
]
}
] | [
{
"id": "split_0_train_48841_entity",
"type": "progene_text",
"text": [
"gadE"
],
"offsets": [
[
17,
21
]
],
"normalized": []
},
{
"id": "split_0_train_48842_entity",
"type": "progene_text",
"text": [
"GadE"
],
"offsets": [
[
119,
123
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30183 | split_0_train_30183 | [
{
"id": "split_0_train_30183_passage",
"type": "progene_text",
"text": [
"The number of regulatory proteins ( five ) , sigma factors ( two ) and regulatory feedback loops focused on gadA / BC expression make this one of the most intensively regulated systems in E. coli ."
],
"offsets": [
[
0,
197
]
]
}
] | [
{
"id": "split_0_train_48843_entity",
"type": "progene_text",
"text": [
"sigma factors"
],
"offsets": [
[
45,
58
]
],
"normalized": []
},
{
"id": "split_0_train_48844_entity",
"type": "progene_text",
"text": [
"gadA / BC"
],
"offsets": [
[
108,
117
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30184 | split_0_train_30184 | [
{
"id": "split_0_train_30184_passage",
"type": "progene_text",
"text": [
"Gene expression of type 2 17 beta hydroxysteroid dehydrogenase in scalp hairs of hirsute women ."
],
"offsets": [
[
0,
96
]
]
}
] | [
{
"id": "split_0_train_48845_entity",
"type": "progene_text",
"text": [
"type 2 17 beta hydroxysteroid dehydrogenase"
],
"offsets": [
[
19,
62
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30185 | split_0_train_30185 | [
{
"id": "split_0_train_30185_passage",
"type": "progene_text",
"text": [
"Androgens are the main hormonal regulators of human hair growth and they are related to clinical conditions such as hirsutism ."
],
"offsets": [
[
0,
127
]
]
}
] | [] | [] | [] | [] |
split_0_train_30186 | split_0_train_30186 | [
{
"id": "split_0_train_30186_passage",
"type": "progene_text",
"text": [
"The aim of this study was to analyze the gene expression of androgen receptor ( AR ) and type 2 17 beta hydroxysteroid dehydrogenase ( 17 beta-HSD ) in keratinocytes of plucked scalp hairs from hirsute patients and normal subjects ."
],
"offsets": [
[
0,
232
]
]
}
] | [
{
"id": "split_0_train_48846_entity",
"type": "progene_text",
"text": [
"androgen receptor"
],
"offsets": [
[
60,
77
]
],
"normalized": []
},
{
"id": "split_0_train_48847_entity",
"type": "progene_text",
"text": [
"AR"
],
"offsets": [
[
80,
82
]
],
"normalized": []
},
{
"id": "split_0_train_48848_entity",
"type": "progene_text",
"text": [
"type 2 17 beta hydroxysteroid dehydrogenase"
],
"offsets": [
[
89,
132
]
],
"normalized": []
},
{
"id": "split_0_train_48849_entity",
"type": "progene_text",
"text": [
"17 beta-HSD"
],
"offsets": [
[
135,
146
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30187 | split_0_train_30187 | [
{
"id": "split_0_train_30187_passage",
"type": "progene_text",
"text": [
"We studied 58 women with hirsutism ( 31 with polycystic ovary syndrome ( PCOS ) , 27 with idiopathic hirsutism ( IH ) ) ; 15 control women ; and 10 control men ."
],
"offsets": [
[
0,
161
]
]
}
] | [] | [] | [] | [] |
split_0_train_30188 | split_0_train_30188 | [
{
"id": "split_0_train_30188_passage",
"type": "progene_text",
"text": [
"Hirsutism was assessed by a modified Ferriman - Gallwey method ."
],
"offsets": [
[
0,
64
]
]
}
] | [] | [] | [] | [] |
split_0_train_30189 | split_0_train_30189 | [
{
"id": "split_0_train_30189_passage",
"type": "progene_text",
"text": [
"Hormonal status was assessed between days 2 and 10 of the menstrual cycle or on any day when the patients were amenorrheic ."
],
"offsets": [
[
0,
124
]
]
}
] | [] | [] | [] | [] |
split_0_train_30190 | split_0_train_30190 | [
{
"id": "split_0_train_30190_passage",
"type": "progene_text",
"text": [
"AR and type 2 17 beta-HSD mRNA levels were estimated by reverse transcription - polymerase chain reaction ( RT - PCR ) ."
],
"offsets": [
[
0,
120
]
]
}
] | [
{
"id": "split_0_train_48850_entity",
"type": "progene_text",
"text": [
"AR"
],
"offsets": [
[
0,
2
]
],
"normalized": []
},
{
"id": "split_0_train_48851_entity",
"type": "progene_text",
"text": [
"type 2 17 beta-HSD"
],
"offsets": [
[
7,
25
]
],
"normalized": []
},
{
"id": "split_0_train_48852_entity",
"type": "progene_text",
"text": [
"polymerase"
],
"offsets": [
[
80,
90
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30191 | split_0_train_30191 | [
{
"id": "split_0_train_30191_passage",
"type": "progene_text",
"text": [
"AR expression was similar in all groups ."
],
"offsets": [
[
0,
41
]
]
}
] | [
{
"id": "split_0_train_48853_entity",
"type": "progene_text",
"text": [
"AR"
],
"offsets": [
[
0,
2
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30192 | split_0_train_30192 | [
{
"id": "split_0_train_30192_passage",
"type": "progene_text",
"text": [
"Type 2 17 beta-HSD gene expression in untreated hirsute patients was lower ( 2.1 +/- 0.10 ) than in normal women ( 3.1 +/- 0.17 ) , and similar to men ( 1.8 +/- 0.22 ) ."
],
"offsets": [
[
0,
169
]
]
}
] | [
{
"id": "split_0_train_48854_entity",
"type": "progene_text",
"text": [
"Type 2 17 beta-HSD"
],
"offsets": [
[
0,
18
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30193 | split_0_train_30193 | [
{
"id": "split_0_train_30193_passage",
"type": "progene_text",
"text": [
"Comparing hirsute patients , type 2 17 beta-HSD expression was higher in treated PCOS ( 3.0 +/- 0.34 versus 2.2 +/- 0.13 ) and IH patients ( 2.5 +/- 0.19 versus 2.0 +/- 0.15 ) ; hirsutism score was lower ( P = 0.003 , PCOS ; P = 0.003 , IH ) ; and SHBG levels were higher ( P = 0.001 , PCOS ; P = 0.024 , IH ) in treated patients ."
],
"offsets": [
[
0,
331
]
]
}
] | [
{
"id": "split_0_train_48855_entity",
"type": "progene_text",
"text": [
"type 2 17 beta-HSD"
],
"offsets": [
[
29,
47
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30194 | split_0_train_30194 | [
{
"id": "split_0_train_30194_passage",
"type": "progene_text",
"text": [
"The free androgen index was lower in treated women ( P = 0.024 for the IH group ) ."
],
"offsets": [
[
0,
83
]
]
}
] | [] | [] | [] | [] |
split_0_train_30195 | split_0_train_30195 | [
{
"id": "split_0_train_30195_passage",
"type": "progene_text",
"text": [
"In conclusion , the lower expression of type 2 17 beta-HSD mRNA in scalp hairs of untreated hirsute patients suggests androgen metabolism disturbances with predominance of more potent androgens , as occurs in men ."
],
"offsets": [
[
0,
214
]
]
}
] | [
{
"id": "split_0_train_48856_entity",
"type": "progene_text",
"text": [
"type 2 17 beta-HSD"
],
"offsets": [
[
40,
58
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30196 | split_0_train_30196 | [
{
"id": "split_0_train_30196_passage",
"type": "progene_text",
"text": [
"The enzyme 's higher gene expression in treated hirsute patients could be an indirect evidence of restored enzyme activity and intracellular androgen metabolism ."
],
"offsets": [
[
0,
162
]
]
}
] | [] | [] | [] | [] |
split_0_train_30197 | split_0_train_30197 | [
{
"id": "split_0_train_30197_passage",
"type": "progene_text",
"text": [
"Structural homology between rbs repressor and ribose binding protein implies functional similarity ."
],
"offsets": [
[
0,
100
]
]
}
] | [
{
"id": "split_0_train_48857_entity",
"type": "progene_text",
"text": [
"rbs repressor"
],
"offsets": [
[
28,
41
]
],
"normalized": []
},
{
"id": "split_0_train_48858_entity",
"type": "progene_text",
"text": [
"ribose binding protein"
],
"offsets": [
[
46,
68
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30198 | split_0_train_30198 | [
{
"id": "split_0_train_30198_passage",
"type": "progene_text",
"text": [
"The deduced amino acid sequence of the rbs repressor , RbsR , of Escherichia coli is homologous over its C-terminal 272 residues to the entire sequence of the periplasmic ribose binding protein ."
],
"offsets": [
[
0,
195
]
]
}
] | [
{
"id": "split_0_train_48859_entity",
"type": "progene_text",
"text": [
"rbs repressor"
],
"offsets": [
[
39,
52
]
],
"normalized": []
},
{
"id": "split_0_train_48860_entity",
"type": "progene_text",
"text": [
"RbsR"
],
"offsets": [
[
55,
59
]
],
"normalized": []
},
{
"id": "split_0_train_48861_entity",
"type": "progene_text",
"text": [
"periplasmic ribose binding protein"
],
"offsets": [
[
159,
193
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30199 | split_0_train_30199 | [
{
"id": "split_0_train_30199_passage",
"type": "progene_text",
"text": [
"RbsR is also homologous to a family of bacterial repressor proteins including LacI ."
],
"offsets": [
[
0,
84
]
]
}
] | [
{
"id": "split_0_train_48862_entity",
"type": "progene_text",
"text": [
"RbsR"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_48863_entity",
"type": "progene_text",
"text": [
"LacI"
],
"offsets": [
[
78,
82
]
],
"normalized": []
}
] | [] | [] | [] |
Subsets and Splits