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stringlengths 15
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split_0_train_29900 | split_0_train_29900 | [
{
"id": "split_0_train_29900_passage",
"type": "progene_text",
"text": [
"This effect was completely inhibited in the presence of the pharmacological ERK 1 / 2 mitogen - activated protein kinase ( MAPK ) pathway inhibitor PD98059 ( 30 microM ) or the p38 MAPK inhibitor SB203580 ( 1 microM ) ."
],
"offsets": [
[
0,
219
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]
}
] | [
{
"id": "split_0_train_48209_entity",
"type": "progene_text",
"text": [
"ERK 1 / 2"
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76,
85
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{
"id": "split_0_train_48210_entity",
"type": "progene_text",
"text": [
"mitogen - activated protein kinase"
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86,
120
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{
"id": "split_0_train_48211_entity",
"type": "progene_text",
"text": [
"MAPK"
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123,
127
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{
"id": "split_0_train_48212_entity",
"type": "progene_text",
"text": [
"p38 MAPK"
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"offsets": [
[
177,
185
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29901 | split_0_train_29901 | [
{
"id": "split_0_train_29901_passage",
"type": "progene_text",
"text": [
"Basal adhesion of normoxic cells was not affected by pretreatment with PD98059 and SB203580 ."
],
"offsets": [
[
0,
93
]
]
}
] | [] | [] | [] | [] |
split_0_train_29902 | split_0_train_29902 | [
{
"id": "split_0_train_29902_passage",
"type": "progene_text",
"text": [
"Hypoxia induced a time - dependent activation of ERK 1 / 2 and p38 MAPK activation in human VSMCs , which were completely abolished by PD98059 or SB203580 , respectively ."
],
"offsets": [
[
0,
171
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]
}
] | [
{
"id": "split_0_train_48213_entity",
"type": "progene_text",
"text": [
"ERK 1 / 2"
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49,
58
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},
{
"id": "split_0_train_48214_entity",
"type": "progene_text",
"text": [
"p38 MAPK"
],
"offsets": [
[
63,
71
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29903 | split_0_train_29903 | [
{
"id": "split_0_train_29903_passage",
"type": "progene_text",
"text": [
"Since adhesion of VSMCs to fibronectin and collagen I involves beta(1)-integrin receptors , we used a blocking antibody against beta(1)-integrin ( P5D2 ) to examine potential effects of hypoxia on beta(1) - integrins ."
],
"offsets": [
[
0,
218
]
]
}
] | [
{
"id": "split_0_train_48215_entity",
"type": "progene_text",
"text": [
"fibronectin"
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27,
38
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],
"normalized": []
},
{
"id": "split_0_train_48216_entity",
"type": "progene_text",
"text": [
"collagen I"
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[
43,
53
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"normalized": []
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{
"id": "split_0_train_48217_entity",
"type": "progene_text",
"text": [
"beta(1)-integrin"
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63,
79
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{
"id": "split_0_train_48218_entity",
"type": "progene_text",
"text": [
"beta(1)-integrin"
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"offsets": [
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128,
144
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],
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},
{
"id": "split_0_train_48219_entity",
"type": "progene_text",
"text": [
"beta(1) - integrins"
],
"offsets": [
[
197,
216
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29904 | split_0_train_29904 | [
{
"id": "split_0_train_29904_passage",
"type": "progene_text",
"text": [
"P5D2 significantly reduced VSMC adhesion to fibronectin and collagen I in normoxia and hypoxia in a comparable manner ; however , beta(1)-integrin protein or mRNA levels were not affected by hypoxia ."
],
"offsets": [
[
0,
200
]
]
}
] | [
{
"id": "split_0_train_48220_entity",
"type": "progene_text",
"text": [
"fibronectin"
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44,
55
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],
"normalized": []
},
{
"id": "split_0_train_48221_entity",
"type": "progene_text",
"text": [
"collagen I"
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"offsets": [
[
60,
70
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],
"normalized": []
},
{
"id": "split_0_train_48222_entity",
"type": "progene_text",
"text": [
"beta(1)-integrin"
],
"offsets": [
[
130,
146
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29905 | split_0_train_29905 | [
{
"id": "split_0_train_29905_passage",
"type": "progene_text",
"text": [
"As evidenced by flow cytometry , hypoxia induced a activation of beta(1)-integrins by exposing an conformationally sensitive epitope on the beta(1) - subunit ."
],
"offsets": [
[
0,
159
]
]
}
] | [
{
"id": "split_0_train_48223_entity",
"type": "progene_text",
"text": [
"beta(1)-integrins"
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"offsets": [
[
65,
82
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],
"normalized": []
},
{
"id": "split_0_train_48224_entity",
"type": "progene_text",
"text": [
"beta(1)"
],
"offsets": [
[
140,
147
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29906 | split_0_train_29906 | [
{
"id": "split_0_train_29906_passage",
"type": "progene_text",
"text": [
"These results demonstrate that hypoxia enhances adhesion of VSMC on extracellular matrix proteins by activating beta(1)-integrin ."
],
"offsets": [
[
0,
130
]
]
}
] | [
{
"id": "split_0_train_48225_entity",
"type": "progene_text",
"text": [
"beta(1)-integrin"
],
"offsets": [
[
112,
128
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29907 | split_0_train_29907 | [
{
"id": "split_0_train_29907_passage",
"type": "progene_text",
"text": [
"Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol ."
],
"offsets": [
[
0,
131
]
]
}
] | [
{
"id": "split_0_train_48226_entity",
"type": "progene_text",
"text": [
"ABCG5"
],
"offsets": [
[
18,
23
]
],
"normalized": []
},
{
"id": "split_0_train_48227_entity",
"type": "progene_text",
"text": [
"ABCG8"
],
"offsets": [
[
28,
33
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29908 | split_0_train_29908 | [
{
"id": "split_0_train_29908_passage",
"type": "progene_text",
"text": [
"Two ATP - binding cassette ( ABC ) transporters , ABCG5 and ABCG8 , have been proposed to limit sterol absorption and to promote biliary sterol excretion in humans ."
],
"offsets": [
[
0,
165
]
]
}
] | [
{
"id": "split_0_train_48228_entity",
"type": "progene_text",
"text": [
"ABCG5"
],
"offsets": [
[
50,
55
]
],
"normalized": []
},
{
"id": "split_0_train_48229_entity",
"type": "progene_text",
"text": [
"ABCG8"
],
"offsets": [
[
60,
65
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29909 | split_0_train_29909 | [
{
"id": "split_0_train_29909_passage",
"type": "progene_text",
"text": [
"To test this hypothesis , a P1 clone containing the human ABCG5 and ABCG8 genes was used to generate transgenic mice ."
],
"offsets": [
[
0,
118
]
]
}
] | [
{
"id": "split_0_train_48230_entity",
"type": "progene_text",
"text": [
"ABCG5"
],
"offsets": [
[
58,
63
]
],
"normalized": []
},
{
"id": "split_0_train_48231_entity",
"type": "progene_text",
"text": [
"ABCG8"
],
"offsets": [
[
68,
73
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29910 | split_0_train_29910 | [
{
"id": "split_0_train_29910_passage",
"type": "progene_text",
"text": [
"The transgenes were expressed primarily in the liver and small intestine , mirroring the expression pattern of the endogenous genes ."
],
"offsets": [
[
0,
133
]
]
}
] | [] | [] | [] | [] |
split_0_train_29911 | split_0_train_29911 | [
{
"id": "split_0_train_29911_passage",
"type": "progene_text",
"text": [
"Transgene expression only modestly affected plasma and liver cholesterol levels but profoundly altered cholesterol transport ."
],
"offsets": [
[
0,
126
]
]
}
] | [] | [] | [] | [] |
split_0_train_29912 | split_0_train_29912 | [
{
"id": "split_0_train_29912_passage",
"type": "progene_text",
"text": [
"The fractional absorption of dietary cholesterol was reduced by about 50 % , and biliary cholesterol levels were increased more than fivefold ."
],
"offsets": [
[
0,
143
]
]
}
] | [] | [] | [] | [] |
split_0_train_29913 | split_0_train_29913 | [
{
"id": "split_0_train_29913_passage",
"type": "progene_text",
"text": [
"Fecal neutral sterol excretion was increased three - to sixfold and hepatic cholesterol synthesis increased two - to fourfold in the transgenic mice ."
],
"offsets": [
[
0,
150
]
]
}
] | [] | [] | [] | [] |
split_0_train_29914 | split_0_train_29914 | [
{
"id": "split_0_train_29914_passage",
"type": "progene_text",
"text": [
"No significant changes in the pool size , composition , and fecal excretion of bile acids were observed in the transgenic mice ."
],
"offsets": [
[
0,
128
]
]
}
] | [] | [] | [] | [] |
split_0_train_29915 | split_0_train_29915 | [
{
"id": "split_0_train_29915_passage",
"type": "progene_text",
"text": [
"Transgene expression attenuated the increase in hepatic cholesterol content induced by consumption of a high cholesterol diet ."
],
"offsets": [
[
0,
127
]
]
}
] | [] | [] | [] | [] |
split_0_train_29916 | split_0_train_29916 | [
{
"id": "split_0_train_29916_passage",
"type": "progene_text",
"text": [
"These results demonstrate that increased expression of ABCG5 and ABCG8 selectively drives biliary neutral sterol secretion and reduces intestinal cholesterol absorption , leading to a selective increase in neutral sterol excretion and a compensatory increase in cholesterol synthesis ."
],
"offsets": [
[
0,
285
]
]
}
] | [
{
"id": "split_0_train_48232_entity",
"type": "progene_text",
"text": [
"ABCG5"
],
"offsets": [
[
55,
60
]
],
"normalized": []
},
{
"id": "split_0_train_48233_entity",
"type": "progene_text",
"text": [
"ABCG8"
],
"offsets": [
[
65,
70
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29917 | split_0_train_29917 | [
{
"id": "split_0_train_29917_passage",
"type": "progene_text",
"text": [
"The Escherichia coli metD locus encodes an ABC transporter which includes Abc ( MetN ) , YaeE ( MetI ) , and YaeC ( MetQ ) ."
],
"offsets": [
[
0,
124
]
]
}
] | [
{
"id": "split_0_train_48234_entity",
"type": "progene_text",
"text": [
"metD"
],
"offsets": [
[
21,
25
]
],
"normalized": []
},
{
"id": "split_0_train_48235_entity",
"type": "progene_text",
"text": [
"ABC transporter"
],
"offsets": [
[
43,
58
]
],
"normalized": []
},
{
"id": "split_0_train_48236_entity",
"type": "progene_text",
"text": [
"Abc"
],
"offsets": [
[
74,
77
]
],
"normalized": []
},
{
"id": "split_0_train_48237_entity",
"type": "progene_text",
"text": [
"MetN"
],
"offsets": [
[
80,
84
]
],
"normalized": []
},
{
"id": "split_0_train_48238_entity",
"type": "progene_text",
"text": [
"YaeE"
],
"offsets": [
[
89,
93
]
],
"normalized": []
},
{
"id": "split_0_train_48239_entity",
"type": "progene_text",
"text": [
"MetI"
],
"offsets": [
[
96,
100
]
],
"normalized": []
},
{
"id": "split_0_train_48240_entity",
"type": "progene_text",
"text": [
"YaeC"
],
"offsets": [
[
109,
113
]
],
"normalized": []
},
{
"id": "split_0_train_48241_entity",
"type": "progene_text",
"text": [
"MetQ"
],
"offsets": [
[
116,
120
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29918 | split_0_train_29918 | [
{
"id": "split_0_train_29918_passage",
"type": "progene_text",
"text": [
"We report that the genes abc , yaeC , and yaeE comprise metD , an Escherichia coli locus encoding a DL-methionine uptake system ."
],
"offsets": [
[
0,
129
]
]
}
] | [
{
"id": "split_0_train_48242_entity",
"type": "progene_text",
"text": [
"abc"
],
"offsets": [
[
25,
28
]
],
"normalized": []
},
{
"id": "split_0_train_48243_entity",
"type": "progene_text",
"text": [
"yaeC"
],
"offsets": [
[
31,
35
]
],
"normalized": []
},
{
"id": "split_0_train_48244_entity",
"type": "progene_text",
"text": [
"yaeE"
],
"offsets": [
[
42,
46
]
],
"normalized": []
},
{
"id": "split_0_train_48245_entity",
"type": "progene_text",
"text": [
"metD"
],
"offsets": [
[
56,
60
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29919 | split_0_train_29919 | [
{
"id": "split_0_train_29919_passage",
"type": "progene_text",
"text": [
"MetD is an ABC transporter with Abc the ATPase , YaeE the permease , and YaeC the likely substrate binding protein ."
],
"offsets": [
[
0,
116
]
]
}
] | [
{
"id": "split_0_train_48246_entity",
"type": "progene_text",
"text": [
"MetD"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_48247_entity",
"type": "progene_text",
"text": [
"ABC transporter"
],
"offsets": [
[
11,
26
]
],
"normalized": []
},
{
"id": "split_0_train_48248_entity",
"type": "progene_text",
"text": [
"Abc"
],
"offsets": [
[
32,
35
]
],
"normalized": []
},
{
"id": "split_0_train_48249_entity",
"type": "progene_text",
"text": [
"ATPase"
],
"offsets": [
[
40,
46
]
],
"normalized": []
},
{
"id": "split_0_train_48250_entity",
"type": "progene_text",
"text": [
"YaeE"
],
"offsets": [
[
49,
53
]
],
"normalized": []
},
{
"id": "split_0_train_48251_entity",
"type": "progene_text",
"text": [
"permease"
],
"offsets": [
[
58,
66
]
],
"normalized": []
},
{
"id": "split_0_train_48252_entity",
"type": "progene_text",
"text": [
"YaeC"
],
"offsets": [
[
73,
77
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29920 | split_0_train_29920 | [
{
"id": "split_0_train_29920_passage",
"type": "progene_text",
"text": [
"Expression of these genes is regulated by L-methionine and MetJ , a common repressor of the methionine regulon ."
],
"offsets": [
[
0,
112
]
]
}
] | [
{
"id": "split_0_train_48253_entity",
"type": "progene_text",
"text": [
"MetJ"
],
"offsets": [
[
59,
63
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29921 | split_0_train_29921 | [
{
"id": "split_0_train_29921_passage",
"type": "progene_text",
"text": [
"We propose to rename abc , yaeE , and yaeC as metN , metI , and metQ , respectively ."
],
"offsets": [
[
0,
85
]
]
}
] | [
{
"id": "split_0_train_48254_entity",
"type": "progene_text",
"text": [
"abc"
],
"offsets": [
[
21,
24
]
],
"normalized": []
},
{
"id": "split_0_train_48255_entity",
"type": "progene_text",
"text": [
"yaeE"
],
"offsets": [
[
27,
31
]
],
"normalized": []
},
{
"id": "split_0_train_48256_entity",
"type": "progene_text",
"text": [
"yaeC"
],
"offsets": [
[
38,
42
]
],
"normalized": []
},
{
"id": "split_0_train_48257_entity",
"type": "progene_text",
"text": [
"metN"
],
"offsets": [
[
46,
50
]
],
"normalized": []
},
{
"id": "split_0_train_48258_entity",
"type": "progene_text",
"text": [
"metI"
],
"offsets": [
[
53,
57
]
],
"normalized": []
},
{
"id": "split_0_train_48259_entity",
"type": "progene_text",
"text": [
"metQ"
],
"offsets": [
[
64,
68
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29922 | split_0_train_29922 | [
{
"id": "split_0_train_29922_passage",
"type": "progene_text",
"text": [
"Expression of trophinin in the cycling endometrium and its association with infertility ."
],
"offsets": [
[
0,
89
]
]
}
] | [
{
"id": "split_0_train_48260_entity",
"type": "progene_text",
"text": [
"trophinin"
],
"offsets": [
[
14,
23
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29923 | split_0_train_29923 | [
{
"id": "split_0_train_29923_passage",
"type": "progene_text",
"text": [
"OBJECTIVE :"
],
"offsets": [
[
0,
11
]
]
}
] | [] | [] | [] | [] |
split_0_train_29924 | split_0_train_29924 | [
{
"id": "split_0_train_29924_passage",
"type": "progene_text",
"text": [
"To observe the expression of trophinin in the cycling endometrium and investigate its relationship with infertility ."
],
"offsets": [
[
0,
117
]
]
}
] | [
{
"id": "split_0_train_48261_entity",
"type": "progene_text",
"text": [
"trophinin"
],
"offsets": [
[
29,
38
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29925 | split_0_train_29925 | [
{
"id": "split_0_train_29925_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
] | [] | [] | [] | [] |
split_0_train_29926 | split_0_train_29926 | [
{
"id": "split_0_train_29926_passage",
"type": "progene_text",
"text": [
"Trophinin expression in the endometrium was observed in 39 normal cycling women during different menstrual phases and 24 women with infertility during mid - luteal phase by immunohistochemical technique ."
],
"offsets": [
[
0,
204
]
]
}
] | [
{
"id": "split_0_train_48262_entity",
"type": "progene_text",
"text": [
"Trophinin"
],
"offsets": [
[
0,
9
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29927 | split_0_train_29927 | [
{
"id": "split_0_train_29927_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
] | [] | [] | [] | [] |
split_0_train_29928 | split_0_train_29928 | [
{
"id": "split_0_train_29928_passage",
"type": "progene_text",
"text": [
"Trophinin expression was detected in the luteal - phase endometrium of both normal and infertile women , which peaked in the mid - luteal phase ."
],
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0,
145
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}
] | [
{
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"text": [
"Trophinin"
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}
] | [] | [] | [] |
split_0_train_29929 | split_0_train_29929 | [
{
"id": "split_0_train_29929_passage",
"type": "progene_text",
"text": [
"In comparison with normal women , infertile women with endometriosis or unexplained infertility had significantly weakened trophinin expression in the endometrium in the mid - luteal ( P < 0.001 ) ."
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] | [
{
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"trophinin"
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123,
132
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] | [] | [] | [] |
split_0_train_29930 | split_0_train_29930 | [
{
"id": "split_0_train_29930_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
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[
0,
13
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}
] | [] | [] | [] | [] |
split_0_train_29931 | split_0_train_29931 | [
{
"id": "split_0_train_29931_passage",
"type": "progene_text",
"text": [
"Trophinin may play an important role in the process of implantation , and abnormal endometrial trophinin expression might be one of the major causes of infertility ."
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{
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"trophinin"
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95,
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}
] | [] | [] | [] |
split_0_train_29932 | split_0_train_29932 | [
{
"id": "split_0_train_29932_passage",
"type": "progene_text",
"text": [
"Microsomal epoxide hydrolase and glutathione S-transferase polymorphisms in relation to laryngeal carcinoma risk ."
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{
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"glutathione S-transferase"
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33,
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}
] | [] | [] | [] |
split_0_train_29933 | split_0_train_29933 | [
{
"id": "split_0_train_29933_passage",
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"text": [
"Two polymorphic sites of the microsomal epoxide hydrolase gene ( EPHX1 , 113Tyr --> 113His , 139His --> 139Arg ) and four glutathione S-transferase genes ( GSTM1 , GSTM3 , GSTP1 , GSTT1 ) were genotyped in a group of patients with larynx cancer ( N = 204 ) and in a group of healthy controls ( N = 203 ) , all Spanish caucasians ."
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156,
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164,
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{
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172,
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{
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"GSTT1"
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180,
185
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],
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}
] | [] | [] | [] |
split_0_train_29934 | split_0_train_29934 | [
{
"id": "split_0_train_29934_passage",
"type": "progene_text",
"text": [
"After adjusting for gender , age , and tobacco smoking , none of the polymorphisms alone were found to be associated with larynx cancer risk ."
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0,
142
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]
}
] | [] | [] | [] | [] |
split_0_train_29935 | split_0_train_29935 | [
{
"id": "split_0_train_29935_passage",
"type": "progene_text",
"text": [
"The analysis of EPHX1 / GST combinations , however , showed a significant over - representation of patients with a combination of 113Tyr / 113Tyr EPHX1 and 105Ile / 105Ile GSTP1 ( adjusted odds ratio ( OR ) : 1.95 ; 95 % confidence interval ( CI ) : 1.02 - 3.78 ) ."
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0,
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}
] | [
{
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{
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24,
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{
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146,
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{
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"text": [
"GSTP1"
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172,
177
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],
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}
] | [] | [] | [] |
split_0_train_29936 | split_0_train_29936 | [
{
"id": "split_0_train_29936_passage",
"type": "progene_text",
"text": [
"The calculation of the predicted epoxide hydrolase ( EH ) activity also showed an increased risk for the individuals with both predicted high activity EH and 105Ile / 105Ile GSTP1 ( OR : 2.90 ; 95 % CI : 1.10 - 7.67 ) ."
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0,
219
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}
] | [
{
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{
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151,
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{
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"GSTP1"
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174,
179
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],
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}
] | [] | [] | [] |
split_0_train_29937 | split_0_train_29937 | [
{
"id": "split_0_train_29937_passage",
"type": "progene_text",
"text": [
"These results on larynx cancer tend to confirm a former study on lung cancer ( Cancer Lett. 173 ( 2001 ) 155 ) suggesting the existence of an interaction between variants of EH and GSTpi , both enzymes being involved in the metabolism of aromatic hydrocarbons , that may increase susceptibility to tobacco - related cancers ."
],
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0,
325
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] | [
{
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174,
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{
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"text": [
"GSTpi"
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181,
186
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],
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}
] | [] | [] | [] |
split_0_train_29938 | split_0_train_29938 | [
{
"id": "split_0_train_29938_passage",
"type": "progene_text",
"text": [
"Post - translational modification of barley 14-3-3A is isoform - specific and involves removal of the hypervariable C - terminus ."
],
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0,
130
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}
] | [
{
"id": "split_0_train_48286_entity",
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"14-3-3A"
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44,
51
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],
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}
] | [] | [] | [] |
split_0_train_29939 | split_0_train_29939 | [
{
"id": "split_0_train_29939_passage",
"type": "progene_text",
"text": [
"The 14-3-3 protein family is a family of regulatory proteins involved in diverse cellular processes ."
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0,
101
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}
] | [
{
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"text": [
"14-3-3 protein family"
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4,
25
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],
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}
] | [] | [] | [] |
split_0_train_29940 | split_0_train_29940 | [
{
"id": "split_0_train_29940_passage",
"type": "progene_text",
"text": [
"In a previous study of regulation of individual 14-3-3 isoforms in the germinating barley embryo , we found that a post - translationally modified , 28 kDa form of 14-3-3A was present in specific cell fractions of the germinated embryo ."
],
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0,
237
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}
] | [
{
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"14-3-3A"
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164,
171
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}
] | [] | [] | [] |
split_0_train_29941 | split_0_train_29941 | [
{
"id": "split_0_train_29941_passage",
"type": "progene_text",
"text": [
"In the present study , we identify the nature of the modification of 14-3-3A , and show that the 28 kDa doublet is the result of cleavage of the C-terminus ."
],
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0,
157
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]
}
] | [
{
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"14-3-3A"
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69,
76
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],
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}
] | [] | [] | [] |
split_0_train_29942 | split_0_train_29942 | [
{
"id": "split_0_train_29942_passage",
"type": "progene_text",
"text": [
"The 28 kDa forms of 14-3-3A lack ten or twelve amino acid residues at the non - conserved C - terminus of the protein , respectively ."
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0,
134
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}
] | [
{
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"14-3-3A"
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20,
27
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}
] | [] | [] | [] |
split_0_train_29943 | split_0_train_29943 | [
{
"id": "split_0_train_29943_passage",
"type": "progene_text",
"text": [
"Barley 14-3-3B and 14-3-3C are not modified in a similar way ."
],
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0,
62
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]
}
] | [
{
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"14-3-3B"
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7,
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{
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"text": [
"14-3-3C"
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19,
26
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],
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}
] | [] | [] | [] |
split_0_train_29944 | split_0_train_29944 | [
{
"id": "split_0_train_29944_passage",
"type": "progene_text",
"text": [
"Like the 30 kDa form , in vitro produced 28 kDa 14-3-3A is still capable of binding AHA2 H+-ATPase in an overlay assay ."
],
"offsets": [
[
0,
120
]
]
}
] | [
{
"id": "split_0_train_48294_entity",
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"14-3-3A"
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48,
55
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{
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"text": [
"AHA2 H+-ATPase"
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[
84,
98
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],
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}
] | [] | [] | [] |
split_0_train_29945 | split_0_train_29945 | [
{
"id": "split_0_train_29945_passage",
"type": "progene_text",
"text": [
"Our results show a novel isoform - specific post - translational modification of 14-3-3 proteins that is regulated in a tissue - specific and developmental way ."
],
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[
0,
161
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]
}
] | [
{
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"type": "progene_text",
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"14-3-3 proteins"
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81,
96
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],
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}
] | [] | [] | [] |
split_0_train_29946 | split_0_train_29946 | [
{
"id": "split_0_train_29946_passage",
"type": "progene_text",
"text": [
"Cdk9 , a member of the cdc2 - like family of kinases , binds to gp130 , the receptor of the IL-6 family of cytokines ."
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"offsets": [
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0,
118
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]
}
] | [
{
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"type": "progene_text",
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{
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23,
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{
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"type": "progene_text",
"text": [
"gp130"
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64,
69
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{
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"type": "progene_text",
"text": [
"IL-6 family of cytokines"
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"offsets": [
[
92,
116
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29947 | split_0_train_29947 | [
{
"id": "split_0_train_29947_passage",
"type": "progene_text",
"text": [
"Cdk9 is a member of the Cdc2 - like family of kinases ."
],
"offsets": [
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0,
55
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]
}
] | [
{
"id": "split_0_train_48301_entity",
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"text": [
"Cdk9"
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4
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{
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"type": "progene_text",
"text": [
"Cdc2 - like family of kinases"
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24,
53
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}
] | [] | [] | [] |
split_0_train_29948 | split_0_train_29948 | [
{
"id": "split_0_train_29948_passage",
"type": "progene_text",
"text": [
"It binds to members of the family of cyclin T ( T1 , T2a and T2b ) and to cyclin K ."
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0,
84
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]
}
] | [
{
"id": "split_0_train_48303_entity",
"type": "progene_text",
"text": [
"cyclin T ( T1 , T2a and T2b )"
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37,
66
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{
"id": "split_0_train_48304_entity",
"type": "progene_text",
"text": [
"cyclin K"
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[
74,
82
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],
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}
] | [] | [] | [] |
split_0_train_29949 | split_0_train_29949 | [
{
"id": "split_0_train_29949_passage",
"type": "progene_text",
"text": [
"The Cdk9 / cyclin T complex appears to be involved in regulating several physiological processes ."
],
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[
0,
98
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]
}
] | [
{
"id": "split_0_train_48305_entity",
"type": "progene_text",
"text": [
"Cdk9"
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4,
8
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{
"id": "split_0_train_48306_entity",
"type": "progene_text",
"text": [
"cyclin T"
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"offsets": [
[
11,
19
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29950 | split_0_train_29950 | [
{
"id": "split_0_train_29950_passage",
"type": "progene_text",
"text": [
"In fact Cdk9 is the kinase of the P-TEFb complex , involved in basal transcription ."
],
"offsets": [
[
0,
84
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]
}
] | [
{
"id": "split_0_train_48307_entity",
"type": "progene_text",
"text": [
"Cdk9"
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8,
12
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{
"id": "split_0_train_48308_entity",
"type": "progene_text",
"text": [
"kinase"
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20,
26
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{
"id": "split_0_train_48309_entity",
"type": "progene_text",
"text": [
"P-TEFb complex"
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"offsets": [
[
34,
48
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29951 | split_0_train_29951 | [
{
"id": "split_0_train_29951_passage",
"type": "progene_text",
"text": [
"Cdk9 has also been described as the kinase of the TAK complex , homologous to P-TEFb and involved in HIV replication ."
],
"offsets": [
[
0,
118
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]
}
] | [
{
"id": "split_0_train_48310_entity",
"type": "progene_text",
"text": [
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0,
4
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{
"id": "split_0_train_48311_entity",
"type": "progene_text",
"text": [
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36,
42
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{
"id": "split_0_train_48312_entity",
"type": "progene_text",
"text": [
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50,
61
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},
{
"id": "split_0_train_48313_entity",
"type": "progene_text",
"text": [
"P-TEFb"
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"offsets": [
[
78,
84
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29952 | split_0_train_29952 | [
{
"id": "split_0_train_29952_passage",
"type": "progene_text",
"text": [
"Here we show that Cdk9 interacts with gp130 , the receptor of the Interleukin-6 ( IL-6 ) family of cytokines , which includes Leukemia Inhibitory Factor ( LIF ) , Oncostatin M ( OSM ) , Ciliary Neurotrophic Factor ( CNTF ) , Interleukin-11 ( IL-11 ) and Cardiotrophin ( CT-1 ) ."
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"offsets": [
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0,
278
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]
}
] | [
{
"id": "split_0_train_48314_entity",
"type": "progene_text",
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18,
22
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{
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"type": "progene_text",
"text": [
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38,
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{
"id": "split_0_train_48316_entity",
"type": "progene_text",
"text": [
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66,
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},
{
"id": "split_0_train_48317_entity",
"type": "progene_text",
"text": [
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126,
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{
"id": "split_0_train_48318_entity",
"type": "progene_text",
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155,
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{
"id": "split_0_train_48319_entity",
"type": "progene_text",
"text": [
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163,
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{
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split_0_train_29953 | split_0_train_29953 | [
{
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] | [] | [] | [] |
split_0_train_29954 | split_0_train_29954 | [
{
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] | [] | [] | [] |
split_0_train_29955 | split_0_train_29955 | [
{
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] | [] | [] | [] |
split_0_train_29956 | split_0_train_29956 | [
{
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] | [] | [] | [] |
split_0_train_29957 | split_0_train_29957 | [
{
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] | [] | [] | [] |
split_0_train_29958 | split_0_train_29958 | [
{
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] | [] | [] | [] |
split_0_train_29959 | split_0_train_29959 | [
{
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"text": [
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] | [] | [] | [] |
split_0_train_29960 | split_0_train_29960 | [
{
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] | [] | [] | [] |
split_0_train_29961 | split_0_train_29961 | [
{
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162,
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] | [] | [] | [] |
split_0_train_29962 | split_0_train_29962 | [
{
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"text": [
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198,
201
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}
] | [] | [] | [] |
split_0_train_29963 | split_0_train_29963 | [
{
"id": "split_0_train_29963_passage",
"type": "progene_text",
"text": [
"The present study has demonstrated that LIGHT inhibits TNFalpha - mediated apoptosis of human primary hepatocytes sensitized by actinomycin D ( ActD ) , but not Fas - or TRAIL - mediated apoptosis ."
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170,
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] | [] | [] | [] |
split_0_train_29964 | split_0_train_29964 | [
{
"id": "split_0_train_29964_passage",
"type": "progene_text",
"text": [
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128
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{
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"TNFalpha"
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98,
106
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}
] | [] | [] | [] |
split_0_train_29965 | split_0_train_29965 | [
{
"id": "split_0_train_29965_passage",
"type": "progene_text",
"text": [
"This protective effect requires LIGHT pretreatment at least 3 h prior to ActD sensitization ."
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{
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32,
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] | [] | [] | [] |
split_0_train_29966 | split_0_train_29966 | [
{
"id": "split_0_train_29966_passage",
"type": "progene_text",
"text": [
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128
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] | [
{
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{
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{
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{
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118,
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}
] | [] | [] | [] |
split_0_train_29967 | split_0_train_29967 | [
{
"id": "split_0_train_29967_passage",
"type": "progene_text",
"text": [
"The time course of NF-kappaB activation after LIGHT administration is similar to that of the pretreatment required for the anti - apoptotic effect of LIGHT ."
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157
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] | [
{
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{
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150,
155
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}
] | [] | [] | [] |
split_0_train_29968 | split_0_train_29968 | [
{
"id": "split_0_train_29968_passage",
"type": "progene_text",
"text": [
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{
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111,
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}
] | [] | [] | [] |
split_0_train_29969 | split_0_train_29969 | [
{
"id": "split_0_train_29969_passage",
"type": "progene_text",
"text": [
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{
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{
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{
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121,
126
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] | [] | [] | [] |
split_0_train_29970 | split_0_train_29970 | [
{
"id": "split_0_train_29970_passage",
"type": "progene_text",
"text": [
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{
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{
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{
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{
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74,
77
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}
] | [] | [] | [] |
split_0_train_29971 | split_0_train_29971 | [
{
"id": "split_0_train_29971_passage",
"type": "progene_text",
"text": [
"These results indicate that LIGHT may act as an anti - apoptotic agent against TNFalpha - mediated liver injury by blocking the activation of both caspase-3 and caspase-8 ."
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172
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}
] | [
{
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{
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{
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{
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161,
170
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] | [] | [] | [] |
split_0_train_29972 | split_0_train_29972 | [
{
"id": "split_0_train_29972_passage",
"type": "progene_text",
"text": [
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157
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{
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{
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{
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67,
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}
] | [] | [] | [] |
split_0_train_29973 | split_0_train_29973 | [
{
"id": "split_0_train_29973_passage",
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] | [] | [] | [] |
split_0_train_29974 | split_0_train_29974 | [
{
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"Fv2 has recently been shown to encode a truncated form of the Stk receptor tyrosine kinase ( Sf-Stk ) ."
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93,
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}
] | [] | [] | [] |
split_0_train_29975 | split_0_train_29975 | [
{
"id": "split_0_train_29975_passage",
"type": "progene_text",
"text": [
"This observation , coupled with earlier work , suggested that Sf-Stk drives the expansion of infected cells by forming a complex with the Friend virus envelope glycoprotein , gp55 , and the erythropoietin receptor ."
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"erythropoietin receptor"
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190,
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}
] | [] | [] | [] |
split_0_train_29976 | split_0_train_29976 | [
{
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"type": "progene_text",
"text": [
"Fv2 has also been implicated in the control of cell cycling in early erythroid progenitors ( erythroid blast - forming units [ BFU-Es]) ."
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] | [] | [] | [] |
split_0_train_29977 | split_0_train_29977 | [
{
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"text": [
"Mouse strains that are homozygous for the resistant allele of Fv2 ( Fv2 ( rr ) ) have few actively cycling BFU-Es ."
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68,
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] | [] | [] | [] |
split_0_train_29978 | split_0_train_29978 | [
{
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"text": [
"In this report , we demonstrate that the control of BFU-E cycling is encoded by a gene linked to , but distinct from , Fv2 , and suggest that this gene is the dual - specific protein phosphatase Cdc25A , which regulates the G1 - to S-phase transition of the cell cycle ."
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195,
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}
] | [] | [] | [] |
split_0_train_29979 | split_0_train_29979 | [
{
"id": "split_0_train_29979_passage",
"type": "progene_text",
"text": [
"We show that a naturally occurring allele of Cdc25A , which increases Cdc25A phosphatase activity and promotes cell - cycle progression , segregates in mouse strains that exhibit high levels of BFU-E cell cycling ."
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214
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"Cdc25A phosphatase"
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70,
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}
] | [] | [] | [] |
split_0_train_29980 | split_0_train_29980 | [
{
"id": "split_0_train_29980_passage",
"type": "progene_text",
"text": [
"In wild - type mice , this allele of Cdc25A does not overtly affect erythropoiesis ; however , when this allele is combined with a mutation of the Kit receptor ( Kit ( WV ) ) , the anemia of the mice is enhanced ."
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"Kit"
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162,
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}
] | [] | [] | [] |
split_0_train_29981 | split_0_train_29981 | [
{
"id": "split_0_train_29981_passage",
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"text": [
"Furthermore , overexpression of Cdc25A in bone marrow cells causes a defect in the BFU-E colony formation ."
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32,
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}
] | [] | [] | [] |
split_0_train_29982 | split_0_train_29982 | [
{
"id": "split_0_train_29982_passage",
"type": "progene_text",
"text": [
"These results suggest that proper regulation of the cell cycle through Cdc25A is required for normal erythropoiesis ."
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}
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71,
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}
] | [] | [] | [] |
split_0_train_29983 | split_0_train_29983 | [
{
"id": "split_0_train_29983_passage",
"type": "progene_text",
"text": [
"IL-4 , but not IL-13 , modulates TARC ( thymus and activation - regulated chemokine ) / CCL17 and IP-10 ( interferon - induced protein of 10kDA ) / CXCL10 release by TNF-alpha and IFN-gamma in HaCaT cell line ."
],
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}
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{
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{
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{
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180,
189
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}
] | [] | [] | [] |
split_0_train_29984 | split_0_train_29984 | [
{
"id": "split_0_train_29984_passage",
"type": "progene_text",
"text": [
"It is known that both interleukin-4 ( IL-4 ) and IL-13 are produced by Th2 - type cells and share similar biological functions with each other ."
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144
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}
] | [
{
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{
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"IL-13"
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49,
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}
] | [] | [] | [] |
split_0_train_29985 | split_0_train_29985 | [
{
"id": "split_0_train_29985_passage",
"type": "progene_text",
"text": [
"However , recently accumulated evidences have revealed that IL-4 may be involved in the Th1 - type response ."
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}
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{
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"IL-4"
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60,
64
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}
] | [] | [] | [] |
split_0_train_29986 | split_0_train_29986 | [
{
"id": "split_0_train_29986_passage",
"type": "progene_text",
"text": [
"Both thymus and activation - regulated chemokine ( TARC / CCL17 ) , a ligand for CC chemokine receptor 4 that is mainly expressed on Th2 - type cells , and interferon - induced protein of 10kDa ( IP-10 / CXCL10 ) , a ligand for CXC chemokine receptor 3 that is mainly expressed on Th1 - type cells , are produced by keratinocytes after the stimulation with the primary cytokines such as tumor necrotic factor - alpha ( TNF-alpha ) and/or interferon-gamma ( IFN-gamma ) ."
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}
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{
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81,
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196,
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{
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204,
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{
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228,
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{
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369,
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{
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387,
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{
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419,
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{
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438,
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{
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"IFN-gamma"
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457,
466
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}
] | [] | [] | [] |
split_0_train_29987 | split_0_train_29987 | [
{
"id": "split_0_train_29987_passage",
"type": "progene_text",
"text": [
"In this study , we investigated the regulation of TARC or IP-10 production from HaCaT cells , an immortalized human keratinocyte cell line , after stimulation with TNF-alpha , IFN-gamma , IL-4 and/or IL-13 ."
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0,
207
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}
] | [
{
"id": "split_0_train_48437_entity",
"type": "progene_text",
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50,
54
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{
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58,
63
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{
"id": "split_0_train_48439_entity",
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164,
173
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{
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176,
185
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{
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"type": "progene_text",
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188,
192
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{
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"IL-13"
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200,
205
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}
] | [] | [] | [] |
split_0_train_29988 | split_0_train_29988 | [
{
"id": "split_0_train_29988_passage",
"type": "progene_text",
"text": [
"Without stimulation , HaCaT cells did not produce TARC ."
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0,
56
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]
}
] | [
{
"id": "split_0_train_48443_entity",
"type": "progene_text",
"text": [
"TARC"
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50,
54
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}
] | [] | [] | [] |
split_0_train_29989 | split_0_train_29989 | [
{
"id": "split_0_train_29989_passage",
"type": "progene_text",
"text": [
"When both TNF-alpha and IFN-gamma were added , they increased synergistically ( P < 0.003 ) ."
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0,
93
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]
}
] | [
{
"id": "split_0_train_48444_entity",
"type": "progene_text",
"text": [
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10,
19
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{
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"IFN-gamma"
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24,
33
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}
] | [] | [] | [] |
split_0_train_29990 | split_0_train_29990 | [
{
"id": "split_0_train_29990_passage",
"type": "progene_text",
"text": [
"In addition , when HaCaT cells were stimulated with IL-4 , but not IL-13 , in combination with TNF-alpha and IFN-gamma , the supernatant TARC levels significantly decreased compared to those with both TNF-alpha and IFN-gamma ( P < 0.009 ) ."
],
"offsets": [
[
0,
240
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]
}
] | [
{
"id": "split_0_train_48446_entity",
"type": "progene_text",
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52,
56
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{
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"type": "progene_text",
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67,
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{
"id": "split_0_train_48448_entity",
"type": "progene_text",
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95,
104
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{
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109,
118
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{
"id": "split_0_train_48450_entity",
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137,
141
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{
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"type": "progene_text",
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201,
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{
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"type": "progene_text",
"text": [
"IFN-gamma"
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215,
224
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}
] | [] | [] | [] |
split_0_train_29991 | split_0_train_29991 | [
{
"id": "split_0_train_29991_passage",
"type": "progene_text",
"text": [
"This inhibition was completely abolished with the addition of neutralizing anti - IL-4 antibody ."
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0,
97
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]
}
] | [
{
"id": "split_0_train_48453_entity",
"type": "progene_text",
"text": [
"IL-4"
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82,
86
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],
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}
] | [] | [] | [] |
split_0_train_29992 | split_0_train_29992 | [
{
"id": "split_0_train_29992_passage",
"type": "progene_text",
"text": [
"The supernatant IP-10 levels also increased synergistically by stimulation with TNF-alpha and IFN-gamma for 24h ( P < 0.001 ) ."
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0,
127
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}
] | [
{
"id": "split_0_train_48454_entity",
"type": "progene_text",
"text": [
"IP-10"
],
"offsets": [
[
16,
21
]
],
"normalized": []
},
{
"id": "split_0_train_48455_entity",
"type": "progene_text",
"text": [
"TNF-alpha"
],
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80,
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]
],
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},
{
"id": "split_0_train_48456_entity",
"type": "progene_text",
"text": [
"IFN-gamma"
],
"offsets": [
[
94,
103
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29993 | split_0_train_29993 | [
{
"id": "split_0_train_29993_passage",
"type": "progene_text",
"text": [
"When IL-4 , but not IL-13 , was added to the medium and the cells were co - cultured with these cytokines , the IP-10 levels significantly increased compared to those with both TNF-alpha and IFN-gamma ( P < 0.04 ) ."
],
"offsets": [
[
0,
215
]
]
}
] | [
{
"id": "split_0_train_48457_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
5,
9
]
],
"normalized": []
},
{
"id": "split_0_train_48458_entity",
"type": "progene_text",
"text": [
"IL-13"
],
"offsets": [
[
20,
25
]
],
"normalized": []
},
{
"id": "split_0_train_48459_entity",
"type": "progene_text",
"text": [
"IP-10"
],
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[
112,
117
]
],
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},
{
"id": "split_0_train_48460_entity",
"type": "progene_text",
"text": [
"TNF-alpha"
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177,
186
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],
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},
{
"id": "split_0_train_48461_entity",
"type": "progene_text",
"text": [
"IFN-gamma"
],
"offsets": [
[
191,
200
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29994 | split_0_train_29994 | [
{
"id": "split_0_train_29994_passage",
"type": "progene_text",
"text": [
"Furthermore , the effects of IL-4 on TARC and IP-10 production in these cells were detected in a dose - dependent manner ."
],
"offsets": [
[
0,
122
]
]
}
] | [
{
"id": "split_0_train_48462_entity",
"type": "progene_text",
"text": [
"IL-4"
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[
29,
33
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],
"normalized": []
},
{
"id": "split_0_train_48463_entity",
"type": "progene_text",
"text": [
"TARC"
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[
37,
41
]
],
"normalized": []
},
{
"id": "split_0_train_48464_entity",
"type": "progene_text",
"text": [
"IP-10"
],
"offsets": [
[
46,
51
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29995 | split_0_train_29995 | [
{
"id": "split_0_train_29995_passage",
"type": "progene_text",
"text": [
"These data strongly suggest that IL-4 may act not only as a mediator of Th1 - type response but also as a down - regulator of Th2 - type response in terms of the regulation of chemokine production by HaCaT cells ."
],
"offsets": [
[
0,
213
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]
}
] | [
{
"id": "split_0_train_48465_entity",
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"IL-4"
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33,
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},
{
"id": "split_0_train_48466_entity",
"type": "progene_text",
"text": [
"chemokine"
],
"offsets": [
[
176,
185
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29996 | split_0_train_29996 | [
{
"id": "split_0_train_29996_passage",
"type": "progene_text",
"text": [
"Identification and characterization of novel surface proteins in Lactobacillus johnsonii and Lactobacillus gasseri ."
],
"offsets": [
[
0,
116
]
]
}
] | [] | [] | [] | [] |
split_0_train_29997 | split_0_train_29997 | [
{
"id": "split_0_train_29997_passage",
"type": "progene_text",
"text": [
"We have identified and sequenced the genes encoding the aggregation - promoting factor ( APF ) protein from six different strains of Lactobacillus johnsonii and Lactobacillus gasseri ."
],
"offsets": [
[
0,
184
]
]
}
] | [
{
"id": "split_0_train_48467_entity",
"type": "progene_text",
"text": [
"aggregation - promoting factor"
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56,
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"normalized": []
},
{
"id": "split_0_train_48468_entity",
"type": "progene_text",
"text": [
"APF"
],
"offsets": [
[
89,
92
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29998 | split_0_train_29998 | [
{
"id": "split_0_train_29998_passage",
"type": "progene_text",
"text": [
"Both species harbor two apf genes , apf1 and apf2 , which are in the same orientation and encode proteins of 257 to 326 amino acids ."
],
"offsets": [
[
0,
133
]
]
}
] | [
{
"id": "split_0_train_48469_entity",
"type": "progene_text",
"text": [
"apf"
],
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[
24,
27
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],
"normalized": []
},
{
"id": "split_0_train_48470_entity",
"type": "progene_text",
"text": [
"apf1"
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[
36,
40
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],
"normalized": []
},
{
"id": "split_0_train_48471_entity",
"type": "progene_text",
"text": [
"apf2"
],
"offsets": [
[
45,
49
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29999 | split_0_train_29999 | [
{
"id": "split_0_train_29999_passage",
"type": "progene_text",
"text": [
"Multiple alignments of the deduced amino acid sequences of these apf genes demonstrate a very strong sequence conservation of all of the genes with the exception of their central regions ."
],
"offsets": [
[
0,
188
]
]
}
] | [
{
"id": "split_0_train_48472_entity",
"type": "progene_text",
"text": [
"apf"
],
"offsets": [
[
65,
68
]
],
"normalized": []
}
] | [] | [] | [] |
Subsets and Splits