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split_0_train_29700 | split_0_train_29700 | [
{
"id": "split_0_train_29700_passage",
"type": "progene_text",
"text": [
"After the failure of the dentine - etch technique , followed by the misfortunes of the chemical dentine adhesion technique , modern dentine adhesive systems are believed to function by a micromechanical attachment mechanism ."
],
"offsets": [
[
0,
225
]
]
}
] | [] | [] | [] | [] |
split_0_train_29701 | split_0_train_29701 | [
{
"id": "split_0_train_29701_passage",
"type": "progene_text",
"text": [
"Based on a morphological study of the resin - dentine interface , a broad selection of dentine adhesive systems was classified following their adhesion - strategy ."
],
"offsets": [
[
0,
164
]
]
}
] | [] | [] | [] | [] |
split_0_train_29702 | split_0_train_29702 | [
{
"id": "split_0_train_29702_passage",
"type": "progene_text",
"text": [
"In a second part , eight dentine adhesive systems were clinically tested in terms of retention ."
],
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0,
96
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]
}
] | [] | [] | [] | [] |
split_0_train_29703 | split_0_train_29703 | [
{
"id": "split_0_train_29703_passage",
"type": "progene_text",
"text": [
"Identification of a domain conferring nucleotide binding to the N-acetyl-d-glucosamine 2-epimerase ( Renin binding protein ) ."
],
"offsets": [
[
0,
126
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]
}
] | [
{
"id": "split_0_train_47788_entity",
"type": "progene_text",
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"N-acetyl-d-glucosamine 2-epimerase"
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64,
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{
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"type": "progene_text",
"text": [
"Renin binding protein"
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[
101,
122
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29704 | split_0_train_29704 | [
{
"id": "split_0_train_29704_passage",
"type": "progene_text",
"text": [
"Renin binding protein ( RnBP ) , a cellular renin inhibitor , has been identified as the enzyme N-acetyl-D-glucosamine ( GlcNAc ) 2-epimerase ."
],
"offsets": [
[
0,
143
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]
}
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{
"id": "split_0_train_47790_entity",
"type": "progene_text",
"text": [
"Renin binding protein"
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"RnBP"
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{
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"type": "progene_text",
"text": [
"renin"
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44,
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{
"id": "split_0_train_47793_entity",
"type": "progene_text",
"text": [
"N-acetyl-D-glucosamine ( GlcNAc ) 2-epimerase"
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[
96,
141
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29705 | split_0_train_29705 | [
{
"id": "split_0_train_29705_passage",
"type": "progene_text",
"text": [
"Our recent studies demonstrated that rat GlcNAc 2-epimerase has a ten - times higher affinity for ATP , dATP , and ddATP than the human enzyme [ Takahashi , S. et al. ( 2001 ) J. Biochem. 130 , 815-821 ] ."
],
"offsets": [
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0,
205
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}
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{
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"type": "progene_text",
"text": [
"GlcNAc 2-epimerase"
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41,
59
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}
] | [] | [] | [] |
split_0_train_29706 | split_0_train_29706 | [
{
"id": "split_0_train_29706_passage",
"type": "progene_text",
"text": [
"To identify the domain conferring nucleotide binding to GlcNAc 2-epimerase , we constructed a series of chimeric enzymes successively replacing the three domains of the human enzyme ( N-terminal , middle , and C-terminal domains ) with the corresponding domains of the rat enzyme ."
],
"offsets": [
[
0,
281
]
]
}
] | [
{
"id": "split_0_train_47795_entity",
"type": "progene_text",
"text": [
"GlcNAc 2-epimerase"
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56,
74
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29707 | split_0_train_29707 | [
{
"id": "split_0_train_29707_passage",
"type": "progene_text",
"text": [
"Chimeras were expressed in Escherichia coli JM109 cells under the control of the Taq promoter ."
],
"offsets": [
[
0,
95
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]
}
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{
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"type": "progene_text",
"text": [
"Taq"
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81,
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"normalized": []
}
] | [] | [] | [] |
split_0_train_29708 | split_0_train_29708 | [
{
"id": "split_0_train_29708_passage",
"type": "progene_text",
"text": [
"The purified chimeric enzymes had GlcNAc 2-epimerase activity and inhibited renin activity in a dose - dependent manner ."
],
"offsets": [
[
0,
121
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]
}
] | [
{
"id": "split_0_train_47797_entity",
"type": "progene_text",
"text": [
"GlcNAc 2-epimerase"
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34,
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{
"id": "split_0_train_47798_entity",
"type": "progene_text",
"text": [
"renin"
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76,
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29709 | split_0_train_29709 | [
{
"id": "split_0_train_29709_passage",
"type": "progene_text",
"text": [
"The recombinant human and rat enzymes required catalytic amounts of ATP with apparent K(m) values of 73 and 5.5 microM , respectively ."
],
"offsets": [
[
0,
135
]
]
}
] | [] | [] | [] | [] |
split_0_train_29710 | split_0_train_29710 | [
{
"id": "split_0_train_29710_passage",
"type": "progene_text",
"text": [
"Chimeric enzymes of HHR , RHH , and RHR ( H , human type domain ; R , rat type domain ) had nearly the same nucleotide specificity as the human GlcNAc 2-epimerase ."
],
"offsets": [
[
0,
164
]
]
}
] | [
{
"id": "split_0_train_47799_entity",
"type": "progene_text",
"text": [
"GlcNAc 2-epimerase"
],
"offsets": [
[
144,
162
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29711 | split_0_train_29711 | [
{
"id": "split_0_train_29711_passage",
"type": "progene_text",
"text": [
"On the other hand , HRR , HRH , and RRH chimeras had the same nucleotide specificity as the rat enzyme ."
],
"offsets": [
[
0,
104
]
]
}
] | [] | [] | [] | [] |
split_0_train_29712 | split_0_train_29712 | [
{
"id": "split_0_train_29712_passage",
"type": "progene_text",
"text": [
"These results indicate that the middle domain of the GlcNAc 2-epimerase molecule participates in the specificity for and binding of nucleotides , and that nucleotides are essential to form the catalytic domain of the enzyme ."
],
"offsets": [
[
0,
225
]
]
}
] | [
{
"id": "split_0_train_47800_entity",
"type": "progene_text",
"text": [
"GlcNAc 2-epimerase"
],
"offsets": [
[
53,
71
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29713 | split_0_train_29713 | [
{
"id": "split_0_train_29713_passage",
"type": "progene_text",
"text": [
"The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue ."
],
"offsets": [
[
0,
111
]
]
}
] | [
{
"id": "split_0_train_47801_entity",
"type": "progene_text",
"text": [
"apolipoprotein L"
],
"offsets": [
[
4,
20
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29714 | split_0_train_29714 | [
{
"id": "split_0_train_29714_passage",
"type": "progene_text",
"text": [
"We previously isolated APOL3 ( CG12-1 ) cDNA and now describe the isolation of APOL1 and APOL2 cDNA from an activated endothelial cell cDNA library and show their endothelialspecific expression in human vascular tissue ."
],
"offsets": [
[
0,
220
]
]
}
] | [
{
"id": "split_0_train_47802_entity",
"type": "progene_text",
"text": [
"APOL3"
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23,
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},
{
"id": "split_0_train_47803_entity",
"type": "progene_text",
"text": [
"CG12-1"
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31,
37
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},
{
"id": "split_0_train_47804_entity",
"type": "progene_text",
"text": [
"APOL1"
],
"offsets": [
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79,
84
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},
{
"id": "split_0_train_47805_entity",
"type": "progene_text",
"text": [
"APOL2"
],
"offsets": [
[
89,
94
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29715 | split_0_train_29715 | [
{
"id": "split_0_train_29715_passage",
"type": "progene_text",
"text": [
"APOL1 - APOL4 are clustered on human chromosome 22q13.1 , as a result of tandem gene duplication , and were detected only in primates ( humans and African green monkeys ) and not in dogs , pigs , or rodents , showing that this gene cluster has arisen recently in evolution ."
],
"offsets": [
[
0,
274
]
]
}
] | [
{
"id": "split_0_train_47806_entity",
"type": "progene_text",
"text": [
"APOL1 - APOL4"
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"offsets": [
[
0,
13
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29716 | split_0_train_29716 | [
{
"id": "split_0_train_29716_passage",
"type": "progene_text",
"text": [
"The specific tissue distribution and gene organization suggest that these genes have diverged rapidly after duplication ."
],
"offsets": [
[
0,
121
]
]
}
] | [] | [] | [] | [] |
split_0_train_29717 | split_0_train_29717 | [
{
"id": "split_0_train_29717_passage",
"type": "progene_text",
"text": [
"This has resulted in the emergence of an additional signal peptide encoding exon that ensures secretion of the plasma high - density lipoprotein - associated APOL1 ."
],
"offsets": [
[
0,
165
]
]
}
] | [
{
"id": "split_0_train_47807_entity",
"type": "progene_text",
"text": [
"high - density lipoprotein"
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"offsets": [
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118,
144
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},
{
"id": "split_0_train_47808_entity",
"type": "progene_text",
"text": [
"APOL1"
],
"offsets": [
[
158,
163
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29718 | split_0_train_29718 | [
{
"id": "split_0_train_29718_passage",
"type": "progene_text",
"text": [
"Our results show that the APOL1 - APOL4 cluster might contribute to the substantial differences in the lipid metabolism of humans and mice , as dictated by the variable expression of genes involved in this process ."
],
"offsets": [
[
0,
215
]
]
}
] | [
{
"id": "split_0_train_47809_entity",
"type": "progene_text",
"text": [
"APOL1 - APOL4"
],
"offsets": [
[
26,
39
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29719 | split_0_train_29719 | [
{
"id": "split_0_train_29719_passage",
"type": "progene_text",
"text": [
"Overexpression of B-type cyclins alters chromosomal segregation ."
],
"offsets": [
[
0,
65
]
]
}
] | [
{
"id": "split_0_train_47810_entity",
"type": "progene_text",
"text": [
"B-type cyclins"
],
"offsets": [
[
18,
32
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29720 | split_0_train_29720 | [
{
"id": "split_0_train_29720_passage",
"type": "progene_text",
"text": [
"To identify genes which overexpression results into chromosomal instability ( CIN ) , we developed a biological approach based on a yeast indicator strain in which CIN can be detected by a sectoring phenotype ."
],
"offsets": [
[
0,
210
]
]
}
] | [] | [] | [] | [] |
split_0_train_29721 | split_0_train_29721 | [
{
"id": "split_0_train_29721_passage",
"type": "progene_text",
"text": [
"Screening in this strain of a yeast genomic library cloned into a high copy vector led us to identify , among the clones generating 100 % of sectoring colonies , Clb5 , one of the six B - type cyclins present in yeast ."
],
"offsets": [
[
0,
219
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]
}
] | [
{
"id": "split_0_train_47811_entity",
"type": "progene_text",
"text": [
"Clb5"
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162,
166
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{
"id": "split_0_train_47812_entity",
"type": "progene_text",
"text": [
"B - type cyclins"
],
"offsets": [
[
184,
200
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29722 | split_0_train_29722 | [
{
"id": "split_0_train_29722_passage",
"type": "progene_text",
"text": [
"Overexpression of cyclin B2 and cyclin B1 , the two human homologs of Clb5 , in the CIN indicator strain resulted also into a sectoring phenotype and induced , like overexpression of Clb5 , an abnormal sensitivity to benomyl , indicating that overexpression of B-type cyclins alters the spindle checkpoint ."
],
"offsets": [
[
0,
307
]
]
}
] | [
{
"id": "split_0_train_47813_entity",
"type": "progene_text",
"text": [
"cyclin B2"
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18,
27
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{
"id": "split_0_train_47814_entity",
"type": "progene_text",
"text": [
"cyclin B1"
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"offsets": [
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32,
41
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"normalized": []
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{
"id": "split_0_train_47815_entity",
"type": "progene_text",
"text": [
"Clb5"
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[
70,
74
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"normalized": []
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{
"id": "split_0_train_47816_entity",
"type": "progene_text",
"text": [
"Clb5"
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"offsets": [
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183,
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{
"id": "split_0_train_47817_entity",
"type": "progene_text",
"text": [
"B-type cyclins"
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"offsets": [
[
261,
275
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29723 | split_0_train_29723 | [
{
"id": "split_0_train_29723_passage",
"type": "progene_text",
"text": [
"In a series of 38 primary colorectal cancers , we detected in five tumors ( 13 % ) an accumulation of cyclin B1 , which was neither related to mRNA overexpression nor to mutation within the coding region , and in five other tumors ( 13 % ) a 2 - 10 - fold increase of cyclin B2 mRNA which was not related to gene amplification ."
],
"offsets": [
[
0,
328
]
]
}
] | [
{
"id": "split_0_train_47818_entity",
"type": "progene_text",
"text": [
"cyclin B1"
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"offsets": [
[
102,
111
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},
{
"id": "split_0_train_47819_entity",
"type": "progene_text",
"text": [
"cyclin B2"
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"offsets": [
[
268,
277
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29724 | split_0_train_29724 | [
{
"id": "split_0_train_29724_passage",
"type": "progene_text",
"text": [
"These results suggest that overexpression of cyclins B , resulting from different mechanisms , could contribute , through an alteration of the spindle checkpoint , to the chromosomal instability observed in cancer ."
],
"offsets": [
[
0,
215
]
]
}
] | [
{
"id": "split_0_train_47820_entity",
"type": "progene_text",
"text": [
"cyclins B"
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"offsets": [
[
45,
54
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29725 | split_0_train_29725 | [
{
"id": "split_0_train_29725_passage",
"type": "progene_text",
"text": [
"Platelet - derived growth factor D : tumorigenicity in mice and dysregulated expression in human cancer ."
],
"offsets": [
[
0,
105
]
]
}
] | [
{
"id": "split_0_train_47821_entity",
"type": "progene_text",
"text": [
"Platelet - derived growth factor D"
],
"offsets": [
[
0,
34
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29726 | split_0_train_29726 | [
{
"id": "split_0_train_29726_passage",
"type": "progene_text",
"text": [
"Platelet - derived growth factor ( PDGF ) has been directly implicated in developmental and physiological processes , as well as in human cancer and other proliferative disorders ."
],
"offsets": [
[
0,
180
]
]
}
] | [
{
"id": "split_0_train_47822_entity",
"type": "progene_text",
"text": [
"Platelet - derived growth factor"
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"offsets": [
[
0,
32
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},
{
"id": "split_0_train_47823_entity",
"type": "progene_text",
"text": [
"PDGF"
],
"offsets": [
[
35,
39
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29727 | split_0_train_29727 | [
{
"id": "split_0_train_29727_passage",
"type": "progene_text",
"text": [
"We have recently isolated and characterized a novel protease - activated member of the PDGF family , PDGF D ."
],
"offsets": [
[
0,
109
]
]
}
] | [
{
"id": "split_0_train_47824_entity",
"type": "progene_text",
"text": [
"protease"
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"offsets": [
[
52,
60
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],
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{
"id": "split_0_train_47825_entity",
"type": "progene_text",
"text": [
"PDGF family"
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"offsets": [
[
87,
98
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],
"normalized": []
},
{
"id": "split_0_train_47826_entity",
"type": "progene_text",
"text": [
"PDGF D"
],
"offsets": [
[
101,
107
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29728 | split_0_train_29728 | [
{
"id": "split_0_train_29728_passage",
"type": "progene_text",
"text": [
"PDGF D has been shown to be proliferative for cells of mesenchymal origin , signaling through PDGF receptors ."
],
"offsets": [
[
0,
110
]
]
}
] | [
{
"id": "split_0_train_47827_entity",
"type": "progene_text",
"text": [
"PDGF D"
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"offsets": [
[
0,
6
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{
"id": "split_0_train_47828_entity",
"type": "progene_text",
"text": [
"PDGF receptors"
],
"offsets": [
[
94,
108
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29729 | split_0_train_29729 | [
{
"id": "split_0_train_29729_passage",
"type": "progene_text",
"text": [
"Comprehensive and systematic PDGF D transcript analysis revealed expression in many cell lines derived from ovarian , renal , and lung cancers , as well as from astrocytomas and medulloblastomas ."
],
"offsets": [
[
0,
196
]
]
}
] | [
{
"id": "split_0_train_47829_entity",
"type": "progene_text",
"text": [
"PDGF D"
],
"offsets": [
[
29,
35
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29730 | split_0_train_29730 | [
{
"id": "split_0_train_29730_passage",
"type": "progene_text",
"text": [
"beta PDGF receptor profiling further suggested autocrine signaling in several brain tumor cell lines ."
],
"offsets": [
[
0,
102
]
]
}
] | [
{
"id": "split_0_train_47830_entity",
"type": "progene_text",
"text": [
"beta PDGF receptor"
],
"offsets": [
[
0,
18
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29731 | split_0_train_29731 | [
{
"id": "split_0_train_29731_passage",
"type": "progene_text",
"text": [
"PDGF D transforming ability and tumor formation in SCID mice was further demonstrated ."
],
"offsets": [
[
0,
87
]
]
}
] | [
{
"id": "split_0_train_47831_entity",
"type": "progene_text",
"text": [
"PDGF D"
],
"offsets": [
[
0,
6
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29732 | split_0_train_29732 | [
{
"id": "split_0_train_29732_passage",
"type": "progene_text",
"text": [
"Exploiting a sensitive PDGF D sandwich ELISA using fully human monoclonal antibodies , PDGF D was detected at elevated levels in the sera of ovarian , renal , lung , and brain cancer patients ."
],
"offsets": [
[
0,
193
]
]
}
] | [
{
"id": "split_0_train_47832_entity",
"type": "progene_text",
"text": [
"PDGF D"
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23,
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],
"normalized": []
},
{
"id": "split_0_train_47833_entity",
"type": "progene_text",
"text": [
"PDGF D"
],
"offsets": [
[
87,
93
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29733 | split_0_train_29733 | [
{
"id": "split_0_train_29733_passage",
"type": "progene_text",
"text": [
"Immunohistochemical analysis confirmed PDGF D localization to ovarian and lung tumor tissues ."
],
"offsets": [
[
0,
94
]
]
}
] | [
{
"id": "split_0_train_47834_entity",
"type": "progene_text",
"text": [
"PDGF D"
],
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[
39,
45
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29734 | split_0_train_29734 | [
{
"id": "split_0_train_29734_passage",
"type": "progene_text",
"text": [
"Together , these data demonstrate that PDGF D plays a role in certain human cancers ."
],
"offsets": [
[
0,
85
]
]
}
] | [
{
"id": "split_0_train_47835_entity",
"type": "progene_text",
"text": [
"PDGF D"
],
"offsets": [
[
39,
45
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29735 | split_0_train_29735 | [
{
"id": "split_0_train_29735_passage",
"type": "progene_text",
"text": [
"Isolation and structure of the mouse 14-3-3 eta chain gene and the distribution of 14-3-3 eta mRNA in the mouse brain ."
],
"offsets": [
[
0,
119
]
]
}
] | [
{
"id": "split_0_train_47836_entity",
"type": "progene_text",
"text": [
"14-3-3 eta"
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"offsets": [
[
37,
47
]
],
"normalized": []
},
{
"id": "split_0_train_47837_entity",
"type": "progene_text",
"text": [
"14-3-3 eta"
],
"offsets": [
[
83,
93
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29736 | split_0_train_29736 | [
{
"id": "split_0_train_29736_passage",
"type": "progene_text",
"text": [
"14-3-3 protein is a brain - specific protein discovered by Moore and Perez , but at present is thought to be a multifunctional protein ."
],
"offsets": [
[
0,
136
]
]
}
] | [
{
"id": "split_0_train_47838_entity",
"type": "progene_text",
"text": [
"14-3-3 protein"
],
"offsets": [
[
0,
14
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29737 | split_0_train_29737 | [
{
"id": "split_0_train_29737_passage",
"type": "progene_text",
"text": [
"To clarify the brain - specific function of the protein , we intend constructing a 14-3-3 eta gene knock - out mouse ."
],
"offsets": [
[
0,
118
]
]
}
] | [
{
"id": "split_0_train_47839_entity",
"type": "progene_text",
"text": [
"14-3-3 eta"
],
"offsets": [
[
83,
93
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29738 | split_0_train_29738 | [
{
"id": "split_0_train_29738_passage",
"type": "progene_text",
"text": [
"As the first step of this process , we isolated the mouse 14-3-3 eta chain gene and determined its structure ."
],
"offsets": [
[
0,
110
]
]
}
] | [
{
"id": "split_0_train_47840_entity",
"type": "progene_text",
"text": [
"14-3-3 eta"
],
"offsets": [
[
58,
68
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29739 | split_0_train_29739 | [
{
"id": "split_0_train_29739_passage",
"type": "progene_text",
"text": [
"The mouse gene is about 10 kb long and composed of two exons separated by a long intron ."
],
"offsets": [
[
0,
89
]
]
}
] | [] | [] | [] | [] |
split_0_train_29740 | split_0_train_29740 | [
{
"id": "split_0_train_29740_passage",
"type": "progene_text",
"text": [
"The transcription start site was identified and the polyadenylation signals ( AATAAA ) were found in exon 2 of the mouse gene ."
],
"offsets": [
[
0,
127
]
]
}
] | [] | [] | [] | [] |
split_0_train_29741 | split_0_train_29741 | [
{
"id": "split_0_train_29741_passage",
"type": "progene_text",
"text": [
"In the 5' - upstream sequence , we found several cis elements including a CRE sequence , a TATA box - like sequence , and a C / EBP element ."
],
"offsets": [
[
0,
141
]
]
}
] | [] | [] | [] | [] |
split_0_train_29742 | split_0_train_29742 | [
{
"id": "split_0_train_29742_passage",
"type": "progene_text",
"text": [
"Furthermore , the distribution of 14-3-3 eta mRNA in the mouse brain was examined by in situ hybridization histochemistry ."
],
"offsets": [
[
0,
123
]
]
}
] | [
{
"id": "split_0_train_47841_entity",
"type": "progene_text",
"text": [
"14-3-3 eta"
],
"offsets": [
[
34,
44
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29743 | split_0_train_29743 | [
{
"id": "split_0_train_29743_passage",
"type": "progene_text",
"text": [
"The highest signals were found in the Purkinje cells of the cerebellum , the pyramidal cells of the hippocampus and the olfactory bulb neurons of the adult mouse ."
],
"offsets": [
[
0,
163
]
]
}
] | [] | [] | [] | [] |
split_0_train_29744 | split_0_train_29744 | [
{
"id": "split_0_train_29744_passage",
"type": "progene_text",
"text": [
"Neuronal expression of 14-3-3 eta in these regions mRNA may generally increase during postnatal brain development ."
],
"offsets": [
[
0,
115
]
]
}
] | [
{
"id": "split_0_train_47842_entity",
"type": "progene_text",
"text": [
"14-3-3 eta"
],
"offsets": [
[
23,
33
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29745 | split_0_train_29745 | [
{
"id": "split_0_train_29745_passage",
"type": "progene_text",
"text": [
"The distribution of protein kinase C gamma in the mouse brain was also examined by immunohistochemistry ."
],
"offsets": [
[
0,
105
]
]
}
] | [
{
"id": "split_0_train_47843_entity",
"type": "progene_text",
"text": [
"protein kinase C gamma"
],
"offsets": [
[
20,
42
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29746 | split_0_train_29746 | [
{
"id": "split_0_train_29746_passage",
"type": "progene_text",
"text": [
"From the distribution of 14-3-3 eta mRNA and protein kinase C gamma in the mouse brain , the involvement of these compounds in the induction and maintenance of LTP was discussed ."
],
"offsets": [
[
0,
179
]
]
}
] | [
{
"id": "split_0_train_47844_entity",
"type": "progene_text",
"text": [
"14-3-3 eta"
],
"offsets": [
[
25,
35
]
],
"normalized": []
},
{
"id": "split_0_train_47845_entity",
"type": "progene_text",
"text": [
"protein kinase C gamma"
],
"offsets": [
[
45,
67
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29747 | split_0_train_29747 | [
{
"id": "split_0_train_29747_passage",
"type": "progene_text",
"text": [
"Polymorphism at GSTM1 , GSTM3 and GSTT1 gene loci and susceptibility to oral cancer in an Indian population ."
],
"offsets": [
[
0,
109
]
]
}
] | [
{
"id": "split_0_train_47846_entity",
"type": "progene_text",
"text": [
"GSTM1"
],
"offsets": [
[
16,
21
]
],
"normalized": []
},
{
"id": "split_0_train_47847_entity",
"type": "progene_text",
"text": [
"GSTM3"
],
"offsets": [
[
24,
29
]
],
"normalized": []
},
{
"id": "split_0_train_47848_entity",
"type": "progene_text",
"text": [
"GSTT1"
],
"offsets": [
[
34,
39
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29748 | split_0_train_29748 | [
{
"id": "split_0_train_29748_passage",
"type": "progene_text",
"text": [
"This study evaluates the influence of genetic polymorphism at GSTM1 , GSTM3 and GSTT1 gene loci on oral cancer risk among Indians habituated to the use of , smokeless tobacco , bidi or cigarette ."
],
"offsets": [
[
0,
196
]
]
}
] | [
{
"id": "split_0_train_47849_entity",
"type": "progene_text",
"text": [
"GSTM1"
],
"offsets": [
[
62,
67
]
],
"normalized": []
},
{
"id": "split_0_train_47850_entity",
"type": "progene_text",
"text": [
"GSTM3"
],
"offsets": [
[
70,
75
]
],
"normalized": []
},
{
"id": "split_0_train_47851_entity",
"type": "progene_text",
"text": [
"GSTT1"
],
"offsets": [
[
80,
85
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29749 | split_0_train_29749 | [
{
"id": "split_0_train_29749_passage",
"type": "progene_text",
"text": [
"DNA extracted from white blood cells of 297 cancer patients and 450 healthy controls by the proteinase K phenol - chloroform extraction procedure were analyzed by the polymerase chain reaction ( PCR ) and PCR - restriction fragment length polymorphism ( RFLP ) analyses ."
],
"offsets": [
[
0,
271
]
]
}
] | [
{
"id": "split_0_train_47852_entity",
"type": "progene_text",
"text": [
"proteinase K"
],
"offsets": [
[
92,
104
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29750 | split_0_train_29750 | [
{
"id": "split_0_train_29750_passage",
"type": "progene_text",
"text": [
"Lifetime tobacco exposure was evaluated as a risk factor in relation to the polymorphism at the GST gene loci using logistic regression analysis ."
],
"offsets": [
[
0,
146
]
]
}
] | [
{
"id": "split_0_train_47853_entity",
"type": "progene_text",
"text": [
"GST"
],
"offsets": [
[
96,
99
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29751 | split_0_train_29751 | [
{
"id": "split_0_train_29751_passage",
"type": "progene_text",
"text": [
"There was no significant difference in the distribution of the GSTM3 and GSTT1 genotypes between oral cancer patients and controls ."
],
"offsets": [
[
0,
132
]
]
}
] | [
{
"id": "split_0_train_47854_entity",
"type": "progene_text",
"text": [
"GSTM3"
],
"offsets": [
[
63,
68
]
],
"normalized": []
},
{
"id": "split_0_train_47855_entity",
"type": "progene_text",
"text": [
"GSTT1"
],
"offsets": [
[
73,
78
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29752 | split_0_train_29752 | [
{
"id": "split_0_train_29752_passage",
"type": "progene_text",
"text": [
"In contrast , a significant 3 - fold increase in risk was seen for patients with the GSTM1 null genotype ( age adjusted OR = 3.2 , 95 % CI 2.4 - 4.3 ) ."
],
"offsets": [
[
0,
152
]
]
}
] | [
{
"id": "split_0_train_47856_entity",
"type": "progene_text",
"text": [
"GSTM1"
],
"offsets": [
[
85,
90
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29753 | split_0_train_29753 | [
{
"id": "split_0_train_29753_passage",
"type": "progene_text",
"text": [
"The impact of the GSTM1 null genotype on oral cancer risk was also analyzed in separate groups of individuals with different tobacco habits ."
],
"offsets": [
[
0,
141
]
]
}
] | [
{
"id": "split_0_train_47857_entity",
"type": "progene_text",
"text": [
"GSTM1"
],
"offsets": [
[
18,
23
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29754 | split_0_train_29754 | [
{
"id": "split_0_train_29754_passage",
"type": "progene_text",
"text": [
"The odds ratio associated with the GSTM1 null genotype was 3.7 ( 95 % CI 2.0 - 7.1 ) in tobacco chewers , 3.7 ( 5 % CI 1.3 - 7.9 ) in bidi smokers and 5.7 ( 95 % CI 2.0 - 16.3 ) in cigarette smokers ."
],
"offsets": [
[
0,
200
]
]
}
] | [
{
"id": "split_0_train_47858_entity",
"type": "progene_text",
"text": [
"GSTM1"
],
"offsets": [
[
35,
40
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29755 | split_0_train_29755 | [
{
"id": "split_0_train_29755_passage",
"type": "progene_text",
"text": [
"Furthermore , increased lifetime exposure to chewing tobacco appeared to be associated with a 2 - fold increase in oral cancer risk in GSTM1 null individuals ."
],
"offsets": [
[
0,
159
]
]
}
] | [
{
"id": "split_0_train_47859_entity",
"type": "progene_text",
"text": [
"GSTM1"
],
"offsets": [
[
135,
140
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29756 | split_0_train_29756 | [
{
"id": "split_0_train_29756_passage",
"type": "progene_text",
"text": [
"The results suggest that the GSTM1 null genotype is a risk factor for development of oral cancer among Indian tobacco habitues ."
],
"offsets": [
[
0,
128
]
]
}
] | [
{
"id": "split_0_train_47860_entity",
"type": "progene_text",
"text": [
"GSTM1"
],
"offsets": [
[
29,
34
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29757 | split_0_train_29757 | [
{
"id": "split_0_train_29757_passage",
"type": "progene_text",
"text": [
"Interaction between p21 - activated protein kinase and Rac during differentiation of HL-60 human promyelocytic leukemia cell induced by all - trans - retinoic acid ."
],
"offsets": [
[
0,
165
]
]
}
] | [
{
"id": "split_0_train_47861_entity",
"type": "progene_text",
"text": [
"p21 - activated protein kinase"
],
"offsets": [
[
20,
50
]
],
"normalized": []
},
{
"id": "split_0_train_47862_entity",
"type": "progene_text",
"text": [
"Rac"
],
"offsets": [
[
55,
58
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29758 | split_0_train_29758 | [
{
"id": "split_0_train_29758_passage",
"type": "progene_text",
"text": [
"Undifferentiated human promyelocytic leukemia HL-60 cells show little or no superoxide production , but generate a very low O(2)(-) concentration upon incubation with all-trans-retinoic acid ( ATRA ) ."
],
"offsets": [
[
0,
201
]
]
}
] | [] | [] | [] | [] |
split_0_train_29759 | split_0_train_29759 | [
{
"id": "split_0_train_29759_passage",
"type": "progene_text",
"text": [
"Its production reaches a maximum within 20 h , and thereafter is maintained at an almost constant level ."
],
"offsets": [
[
0,
105
]
]
}
] | [] | [] | [] | [] |
split_0_train_29760 | split_0_train_29760 | [
{
"id": "split_0_train_29760_passage",
"type": "progene_text",
"text": [
"The differentiated cells show phorbol 12-myristate 13-acetate ( PMA ) - stimulated NADPH oxidase activity consistent with the amount of gp91phox ( phagocytic oxidase ) expressed in the plasma membrane ."
],
"offsets": [
[
0,
202
]
]
}
] | [
{
"id": "split_0_train_47863_entity",
"type": "progene_text",
"text": [
"NADPH oxidase"
],
"offsets": [
[
83,
96
]
],
"normalized": []
},
{
"id": "split_0_train_47864_entity",
"type": "progene_text",
"text": [
"gp91phox"
],
"offsets": [
[
136,
144
]
],
"normalized": []
},
{
"id": "split_0_train_47865_entity",
"type": "progene_text",
"text": [
"oxidase"
],
"offsets": [
[
158,
165
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29761 | split_0_train_29761 | [
{
"id": "split_0_train_29761_passage",
"type": "progene_text",
"text": [
"Three isoforms of p21 - activated serine / threonine kinases , PAK68 , PAK65 and PAK62 , were found in both cytosolic and membrane fractions , and their contents were significantly increased during induced differentiation ."
],
"offsets": [
[
0,
223
]
]
}
] | [
{
"id": "split_0_train_47866_entity",
"type": "progene_text",
"text": [
"p21 - activated serine / threonine kinases"
],
"offsets": [
[
18,
60
]
],
"normalized": []
},
{
"id": "split_0_train_47867_entity",
"type": "progene_text",
"text": [
"PAK68"
],
"offsets": [
[
63,
68
]
],
"normalized": []
},
{
"id": "split_0_train_47868_entity",
"type": "progene_text",
"text": [
"PAK65"
],
"offsets": [
[
71,
76
]
],
"normalized": []
},
{
"id": "split_0_train_47869_entity",
"type": "progene_text",
"text": [
"PAK62"
],
"offsets": [
[
81,
86
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29762 | split_0_train_29762 | [
{
"id": "split_0_train_29762_passage",
"type": "progene_text",
"text": [
"The amount of Rac identified in the two fractions was also markedly enhanced by ATRA - induced differentiation ."
],
"offsets": [
[
0,
112
]
]
}
] | [
{
"id": "split_0_train_47870_entity",
"type": "progene_text",
"text": [
"Rac"
],
"offsets": [
[
14,
17
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29763 | split_0_train_29763 | [
{
"id": "split_0_train_29763_passage",
"type": "progene_text",
"text": [
"In contrast , neither PAK nor Rac was seen in the plasma membrane of undifferentiated HL-60 or human neutrophil , but they were abundant in the cytoplasmic fraction ."
],
"offsets": [
[
0,
166
]
]
}
] | [
{
"id": "split_0_train_47871_entity",
"type": "progene_text",
"text": [
"PAK"
],
"offsets": [
[
22,
25
]
],
"normalized": []
},
{
"id": "split_0_train_47872_entity",
"type": "progene_text",
"text": [
"Rac"
],
"offsets": [
[
30,
33
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29764 | split_0_train_29764 | [
{
"id": "split_0_train_29764_passage",
"type": "progene_text",
"text": [
"Binding of Rac with PAK isoforms was shown in the membrane upon induced differentiation of HL-60 cells ."
],
"offsets": [
[
0,
104
]
]
}
] | [
{
"id": "split_0_train_47873_entity",
"type": "progene_text",
"text": [
"Rac"
],
"offsets": [
[
11,
14
]
],
"normalized": []
},
{
"id": "split_0_train_47874_entity",
"type": "progene_text",
"text": [
"PAK"
],
"offsets": [
[
20,
23
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29765 | split_0_train_29765 | [
{
"id": "split_0_train_29765_passage",
"type": "progene_text",
"text": [
"Direct binding of purified Rac1 to PAK68 was quantified using a fluorescent analog of GTP ( methylanthraniloyl guanosine-5'-[beta,gamma-imido]triphosphate ) bound to Rac as a reporter group ."
],
"offsets": [
[
0,
191
]
]
}
] | [
{
"id": "split_0_train_47875_entity",
"type": "progene_text",
"text": [
"Rac1"
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27,
31
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},
{
"id": "split_0_train_47876_entity",
"type": "progene_text",
"text": [
"PAK68"
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35,
40
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},
{
"id": "split_0_train_47877_entity",
"type": "progene_text",
"text": [
"Rac"
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[
166,
169
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29766 | split_0_train_29766 | [
{
"id": "split_0_train_29766_passage",
"type": "progene_text",
"text": [
"Rac1 bound to PAK68 with a 1 : 1 stoichiometry and with a K(d) value of 6.7 nm ."
],
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[
0,
80
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]
}
] | [
{
"id": "split_0_train_47878_entity",
"type": "progene_text",
"text": [
"Rac1"
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0,
4
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},
{
"id": "split_0_train_47879_entity",
"type": "progene_text",
"text": [
"PAK68"
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[
14,
19
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29767 | split_0_train_29767 | [
{
"id": "split_0_train_29767_passage",
"type": "progene_text",
"text": [
"Acute effects of acephate and methamidophos and interleukin-1 on corticotropin - releasing factor ( CRF ) synthesis in and release from the hypothalamus in vitro ."
],
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[
0,
163
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]
}
] | [
{
"id": "split_0_train_47880_entity",
"type": "progene_text",
"text": [
"interleukin-1"
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48,
61
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},
{
"id": "split_0_train_47881_entity",
"type": "progene_text",
"text": [
"corticotropin - releasing factor"
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65,
97
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},
{
"id": "split_0_train_47882_entity",
"type": "progene_text",
"text": [
"CRF"
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"offsets": [
[
100,
103
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29768 | split_0_train_29768 | [
{
"id": "split_0_train_29768_passage",
"type": "progene_text",
"text": [
"Acute effects of Ace , Meth and IL-1 on AChE activity , ACh and CRF mRNA levels in , and CRF - release from the hypothalamus were studied in vitro ."
],
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[
0,
148
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]
}
] | [
{
"id": "split_0_train_47883_entity",
"type": "progene_text",
"text": [
"IL-1"
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32,
36
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{
"id": "split_0_train_47884_entity",
"type": "progene_text",
"text": [
"AChE"
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40,
44
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{
"id": "split_0_train_47885_entity",
"type": "progene_text",
"text": [
"CRF"
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64,
67
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{
"id": "split_0_train_47886_entity",
"type": "progene_text",
"text": [
"CRF"
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"offsets": [
[
89,
92
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29769 | split_0_train_29769 | [
{
"id": "split_0_train_29769_passage",
"type": "progene_text",
"text": [
"The hypothalamus samples were dissected from the rat brain and were incubated in vitro with IL-1 , Ace or Meth in the presence or absence of Dex , Atrop , PTL , PROP and GABA ."
],
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[
0,
176
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]
}
] | [
{
"id": "split_0_train_47887_entity",
"type": "progene_text",
"text": [
"IL-1"
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[
92,
96
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29770 | split_0_train_29770 | [
{
"id": "split_0_train_29770_passage",
"type": "progene_text",
"text": [
"Ace and Meth , but not IL-1 , inhibited AChE activity , while all three compounds ; ( 1 ) increased ACh and CRF mRNA levels in and CRF release from ; ( 2 ) activated the CRE promoter region of CRF - gene in : and ( 3 ) increased cFos binding to the AP-1 region of the CRF - gene in the hypothalamus ."
],
"offsets": [
[
0,
300
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]
}
] | [
{
"id": "split_0_train_47888_entity",
"type": "progene_text",
"text": [
"IL-1"
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23,
27
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"normalized": []
},
{
"id": "split_0_train_47889_entity",
"type": "progene_text",
"text": [
"AChE"
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40,
44
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},
{
"id": "split_0_train_47890_entity",
"type": "progene_text",
"text": [
"CRF"
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108,
111
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},
{
"id": "split_0_train_47891_entity",
"type": "progene_text",
"text": [
"CRF"
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131,
134
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{
"id": "split_0_train_47892_entity",
"type": "progene_text",
"text": [
"CRF"
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193,
196
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},
{
"id": "split_0_train_47893_entity",
"type": "progene_text",
"text": [
"cFos"
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229,
233
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"normalized": []
},
{
"id": "split_0_train_47894_entity",
"type": "progene_text",
"text": [
"AP-1"
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249,
253
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"normalized": []
},
{
"id": "split_0_train_47895_entity",
"type": "progene_text",
"text": [
"CRF"
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"offsets": [
[
268,
271
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29771 | split_0_train_29771 | [
{
"id": "split_0_train_29771_passage",
"type": "progene_text",
"text": [
"Dex suppressed the effects of IL-1 , possibly by inducing the nGRE regulatory sites of the CRF - gene ."
],
"offsets": [
[
0,
103
]
]
}
] | [
{
"id": "split_0_train_47896_entity",
"type": "progene_text",
"text": [
"IL-1"
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"offsets": [
[
30,
34
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],
"normalized": []
},
{
"id": "split_0_train_47897_entity",
"type": "progene_text",
"text": [
"CRF"
],
"offsets": [
[
91,
94
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29772 | split_0_train_29772 | [
{
"id": "split_0_train_29772_passage",
"type": "progene_text",
"text": [
"Dex , however , did not modulate the effects of Ace and Meth on the hypothalamus , which may be attributed to the failure of Dex to modulate the CRF - gene ' s nGRE regulatory sites ."
],
"offsets": [
[
0,
183
]
]
}
] | [
{
"id": "split_0_train_47898_entity",
"type": "progene_text",
"text": [
"CRF"
],
"offsets": [
[
145,
148
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29773 | split_0_train_29773 | [
{
"id": "split_0_train_29773_passage",
"type": "progene_text",
"text": [
"Atrop caused 80 - 90 % inhibition of the effects of IL-1 , but caused only 50 - 65 % inhibition of the effects of Ace or Meth on CRF mRNA levels in and CRF release from the hypothalamus ."
],
"offsets": [
[
0,
187
]
]
}
] | [
{
"id": "split_0_train_47899_entity",
"type": "progene_text",
"text": [
"IL-1"
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"offsets": [
[
52,
56
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],
"normalized": []
},
{
"id": "split_0_train_47900_entity",
"type": "progene_text",
"text": [
"CRF"
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"offsets": [
[
129,
132
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],
"normalized": []
},
{
"id": "split_0_train_47901_entity",
"type": "progene_text",
"text": [
"CRF"
],
"offsets": [
[
152,
155
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29774 | split_0_train_29774 | [
{
"id": "split_0_train_29774_passage",
"type": "progene_text",
"text": [
"PTL did not affect , while PROP slightly attenuated the effects of IL-1 and the insecticides on the hypothalamus ."
],
"offsets": [
[
0,
114
]
]
}
] | [
{
"id": "split_0_train_47902_entity",
"type": "progene_text",
"text": [
"IL-1"
],
"offsets": [
[
67,
71
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29775 | split_0_train_29775 | [
{
"id": "split_0_train_29775_passage",
"type": "progene_text",
"text": [
"GABA attenuated the effects of the insecticides but not the effects of IL-1 on the hypothalamus ."
],
"offsets": [
[
0,
97
]
]
}
] | [
{
"id": "split_0_train_47903_entity",
"type": "progene_text",
"text": [
"IL-1"
],
"offsets": [
[
71,
75
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29776 | split_0_train_29776 | [
{
"id": "split_0_train_29776_passage",
"type": "progene_text",
"text": [
"This suggests that the IL-1 - induced augmentation of CRF synthesis in and release from the hypothalamus is mediated through a cholinergic pathway , while the insecticide - induced augmentation of CRF synthesis in and release from the hypothalamus is mediated through the cholinergic and GABAergic pathways ."
],
"offsets": [
[
0,
308
]
]
}
] | [
{
"id": "split_0_train_47904_entity",
"type": "progene_text",
"text": [
"IL-1"
],
"offsets": [
[
23,
27
]
],
"normalized": []
},
{
"id": "split_0_train_47905_entity",
"type": "progene_text",
"text": [
"CRF"
],
"offsets": [
[
54,
57
]
],
"normalized": []
},
{
"id": "split_0_train_47906_entity",
"type": "progene_text",
"text": [
"CRF"
],
"offsets": [
[
197,
200
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29777 | split_0_train_29777 | [
{
"id": "split_0_train_29777_passage",
"type": "progene_text",
"text": [
"The insecticides , but not IL-1 , disrupt feedback regulation of CRF synthesis in and release from the hypothalamus ."
],
"offsets": [
[
0,
117
]
]
}
] | [
{
"id": "split_0_train_47907_entity",
"type": "progene_text",
"text": [
"IL-1"
],
"offsets": [
[
27,
31
]
],
"normalized": []
},
{
"id": "split_0_train_47908_entity",
"type": "progene_text",
"text": [
"CRF"
],
"offsets": [
[
65,
68
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29778 | split_0_train_29778 | [
{
"id": "split_0_train_29778_passage",
"type": "progene_text",
"text": [
"Expression of the Musashi1 gene encoding the RNA - binding protein in human hepatoma cell lines ."
],
"offsets": [
[
0,
97
]
]
}
] | [
{
"id": "split_0_train_47909_entity",
"type": "progene_text",
"text": [
"Musashi1"
],
"offsets": [
[
18,
26
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29779 | split_0_train_29779 | [
{
"id": "split_0_train_29779_passage",
"type": "progene_text",
"text": [
"Musashi1 , a neural RNA - binding protein , plays an important role in regulating cell differentiation in precursor cells ."
],
"offsets": [
[
0,
123
]
]
}
] | [
{
"id": "split_0_train_47910_entity",
"type": "progene_text",
"text": [
"Musashi1"
],
"offsets": [
[
0,
8
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29780 | split_0_train_29780 | [
{
"id": "split_0_train_29780_passage",
"type": "progene_text",
"text": [
"Recently , expression of Musashi1 has been detected in human tumor tissues such as gliomas and melanomas , suggesting its involvement in oncogenic development ."
],
"offsets": [
[
0,
160
]
]
}
] | [
{
"id": "split_0_train_47911_entity",
"type": "progene_text",
"text": [
"Musashi1"
],
"offsets": [
[
25,
33
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29781 | split_0_train_29781 | [
{
"id": "split_0_train_29781_passage",
"type": "progene_text",
"text": [
"To determine any association between Musashi1 and the development of liver cancer , we investigated its gene expression in seven human hepatoma cell lines : HuH6 , HuH7 , Hep3B , SK-Hep1 , HepG2 , HLE , and HLF ."
],
"offsets": [
[
0,
212
]
]
}
] | [
{
"id": "split_0_train_47912_entity",
"type": "progene_text",
"text": [
"Musashi1"
],
"offsets": [
[
37,
45
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29782 | split_0_train_29782 | [
{
"id": "split_0_train_29782_passage",
"type": "progene_text",
"text": [
"Musashi1 mRNA expression was analyzed using the reverse - transcription polymerase chain reaction ( PCR ) , and the PCR products were sequenced using a subcloning procedure ."
],
"offsets": [
[
0,
174
]
]
}
] | [
{
"id": "split_0_train_47913_entity",
"type": "progene_text",
"text": [
"Musashi1"
],
"offsets": [
[
0,
8
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29783 | split_0_train_29783 | [
{
"id": "split_0_train_29783_passage",
"type": "progene_text",
"text": [
"Musashi1 protein expression was analyzed in HuH7 and HepG2 cells by Western blot and immunofluorescence staining ."
],
"offsets": [
[
0,
114
]
]
}
] | [
{
"id": "split_0_train_47914_entity",
"type": "progene_text",
"text": [
"Musashi1"
],
"offsets": [
[
0,
8
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29784 | split_0_train_29784 | [
{
"id": "split_0_train_29784_passage",
"type": "progene_text",
"text": [
"Musashi1 mRNA was detected in the HuH6 , HuH7 , and Hep3B hepatoma cell lines , but not in the others ."
],
"offsets": [
[
0,
103
]
]
}
] | [
{
"id": "split_0_train_47915_entity",
"type": "progene_text",
"text": [
"Musashi1"
],
"offsets": [
[
0,
8
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29785 | split_0_train_29785 | [
{
"id": "split_0_train_29785_passage",
"type": "progene_text",
"text": [
"Sequencing of the PCR - amplified Musashi1 cDNA in these three cell lines showed the expected sequence of the human Musashi1 gene ."
],
"offsets": [
[
0,
131
]
]
}
] | [
{
"id": "split_0_train_47916_entity",
"type": "progene_text",
"text": [
"Musashi1"
],
"offsets": [
[
34,
42
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],
"normalized": []
},
{
"id": "split_0_train_47917_entity",
"type": "progene_text",
"text": [
"Musashi1"
],
"offsets": [
[
116,
124
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29786 | split_0_train_29786 | [
{
"id": "split_0_train_29786_passage",
"type": "progene_text",
"text": [
"Musashi1 protein expression was confirmed in HuH7 cells , which were positive for Musashi1 mRNA expression , but not in HepG2 cells ."
],
"offsets": [
[
0,
133
]
]
}
] | [
{
"id": "split_0_train_47918_entity",
"type": "progene_text",
"text": [
"Musashi1"
],
"offsets": [
[
0,
8
]
],
"normalized": []
},
{
"id": "split_0_train_47919_entity",
"type": "progene_text",
"text": [
"Musashi1"
],
"offsets": [
[
82,
90
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29787 | split_0_train_29787 | [
{
"id": "split_0_train_29787_passage",
"type": "progene_text",
"text": [
"These results suggest that Musashi1 expression may be an important factor in the development of several types of carcinoma such as human hepatoma , and may be a useful molecular marker for tumor detection ."
],
"offsets": [
[
0,
206
]
]
}
] | [
{
"id": "split_0_train_47920_entity",
"type": "progene_text",
"text": [
"Musashi1"
],
"offsets": [
[
27,
35
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29788 | split_0_train_29788 | [
{
"id": "split_0_train_29788_passage",
"type": "progene_text",
"text": [
"Coexpression of oncostatin M and its receptors and evidence for STAT3 activation in human ovarian carcinomas ."
],
"offsets": [
[
0,
110
]
]
}
] | [
{
"id": "split_0_train_47921_entity",
"type": "progene_text",
"text": [
"oncostatin M"
],
"offsets": [
[
16,
28
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],
"normalized": []
},
{
"id": "split_0_train_47922_entity",
"type": "progene_text",
"text": [
"STAT3"
],
"offsets": [
[
64,
69
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29789 | split_0_train_29789 | [
{
"id": "split_0_train_29789_passage",
"type": "progene_text",
"text": [
"The expression of oncostatin M and leukemia inhibitory factor ( LIF ) , JAK - STAT activators and members of the interleukin-6 family of cytokines , were examined in a series of primary ovarian carcinomas using immunohistochemistry ."
],
"offsets": [
[
0,
233
]
]
}
] | [
{
"id": "split_0_train_47923_entity",
"type": "progene_text",
"text": [
"oncostatin M"
],
"offsets": [
[
18,
30
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],
"normalized": []
},
{
"id": "split_0_train_47924_entity",
"type": "progene_text",
"text": [
"leukemia inhibitory factor"
],
"offsets": [
[
35,
61
]
],
"normalized": []
},
{
"id": "split_0_train_47925_entity",
"type": "progene_text",
"text": [
"LIF"
],
"offsets": [
[
64,
67
]
],
"normalized": []
},
{
"id": "split_0_train_47926_entity",
"type": "progene_text",
"text": [
"JAK"
],
"offsets": [
[
72,
75
]
],
"normalized": []
},
{
"id": "split_0_train_47927_entity",
"type": "progene_text",
"text": [
"STAT"
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"offsets": [
[
78,
82
]
],
"normalized": []
},
{
"id": "split_0_train_47928_entity",
"type": "progene_text",
"text": [
"interleukin-6 family of cytokines"
],
"offsets": [
[
113,
146
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29790 | split_0_train_29790 | [
{
"id": "split_0_train_29790_passage",
"type": "progene_text",
"text": [
"The malignant epithelial cells of all 29 ovarian carcinomas examined expressed oncostatin M ; none expressed LIF ."
],
"offsets": [
[
0,
114
]
]
}
] | [
{
"id": "split_0_train_47929_entity",
"type": "progene_text",
"text": [
"oncostatin M"
],
"offsets": [
[
79,
91
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],
"normalized": []
},
{
"id": "split_0_train_47930_entity",
"type": "progene_text",
"text": [
"LIF"
],
"offsets": [
[
109,
112
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29791 | split_0_train_29791 | [
{
"id": "split_0_train_29791_passage",
"type": "progene_text",
"text": [
"Oncostatin M can activate two related receptors , one consisting of a low - affinity LIF receptor subunit , LIFR beta , which forms a heterocomplex with the gp130 signal transducing protein and can recognize both oncostatin M and LIF , and a second heterocomplex consisting of a subunit that specifically recognizes oncostatin M , OSMR beta , and the gp130 protein ."
],
"offsets": [
[
0,
366
]
]
}
] | [
{
"id": "split_0_train_47931_entity",
"type": "progene_text",
"text": [
"Oncostatin M"
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0,
12
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"normalized": []
},
{
"id": "split_0_train_47932_entity",
"type": "progene_text",
"text": [
"LIF receptor"
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85,
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},
{
"id": "split_0_train_47933_entity",
"type": "progene_text",
"text": [
"LIFR"
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108,
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},
{
"id": "split_0_train_47934_entity",
"type": "progene_text",
"text": [
"gp130"
],
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[
157,
162
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],
"normalized": []
},
{
"id": "split_0_train_47935_entity",
"type": "progene_text",
"text": [
"oncostatin M"
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[
213,
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],
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},
{
"id": "split_0_train_47936_entity",
"type": "progene_text",
"text": [
"LIF"
],
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[
230,
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},
{
"id": "split_0_train_47937_entity",
"type": "progene_text",
"text": [
"oncostatin M"
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316,
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},
{
"id": "split_0_train_47938_entity",
"type": "progene_text",
"text": [
"OSMR beta"
],
"offsets": [
[
331,
340
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"normalized": []
},
{
"id": "split_0_train_47939_entity",
"type": "progene_text",
"text": [
"gp130"
],
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[
351,
356
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],
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}
] | [] | [] | [] |
split_0_train_29792 | split_0_train_29792 | [
{
"id": "split_0_train_29792_passage",
"type": "progene_text",
"text": [
"By immunohistochemistry , 25 of 25 ovarian carcinomas examined expressed the LIFR beta subunit in the malignant epithelial cells ( all samples express gp130 ) , and two - thirds the ovarian carcinomas studied expressed OSMR beta mRNA as determined by RT - PCR ."
],
"offsets": [
[
0,
261
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]
}
] | [
{
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"LIFR"
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77,
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{
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151,
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},
{
"id": "split_0_train_47942_entity",
"type": "progene_text",
"text": [
"OSMR beta"
],
"offsets": [
[
219,
228
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29793 | split_0_train_29793 | [
{
"id": "split_0_train_29793_passage",
"type": "progene_text",
"text": [
"Thus oncostatin M and its receptors are commonly coexpressed in malignant ovarian epithelial cells , and represent a potential autocrine loop in this tumor type ."
],
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0,
162
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] | [
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"text": [
"oncostatin M"
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5,
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] | [] | [] | [] |
split_0_train_29794 | split_0_train_29794 | [
{
"id": "split_0_train_29794_passage",
"type": "progene_text",
"text": [
"STAT3 , of one the signaling proteins downstream of the oncostatin M / LIF receptors , was found in its phosphorylated , activated form ( phosphotyrosine 705 STAT3 ) in the malignant epithelial cells of 17 of 23 ovarian carcinomas examined ( 74 % ) as determined by immunohistochemistry ; this suggests that this protein is constitutively activated in most ovarian carcinomas , as it is in many other human malignancies ."
],
"offsets": [
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0,
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] | [
{
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"STAT3"
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{
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{
"id": "split_0_train_47946_entity",
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"STAT3"
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158,
163
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}
] | [] | [] | [] |
split_0_train_29795 | split_0_train_29795 | [
{
"id": "split_0_train_29795_passage",
"type": "progene_text",
"text": [
"Recombinant human Oncostatin M ( rhOSM ) can induce the transient tyrosine 705 phosphorylation of STAT3 in serum - starved LIFR beta / OSMR beta expressing ovarian carcinoma cell lines , but does not alter cell growth and effects only a modest increase in the apoptotic rate in these cultured cells ."
],
"offsets": [
[
0,
300
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}
] | [
{
"id": "split_0_train_47947_entity",
"type": "progene_text",
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"Oncostatin M"
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[
18,
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{
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"rhOSM"
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33,
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{
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"STAT3"
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98,
103
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},
{
"id": "split_0_train_47950_entity",
"type": "progene_text",
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"LIFR"
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123,
127
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},
{
"id": "split_0_train_47951_entity",
"type": "progene_text",
"text": [
"OSMR beta"
],
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[
135,
144
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],
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}
] | [] | [] | [] |
split_0_train_29796 | split_0_train_29796 | [
{
"id": "split_0_train_29796_passage",
"type": "progene_text",
"text": [
"Oncostatin M and its receptors may be part of a network of cytokine systems within ovarian carcinomas that may act to maintain STAT3 in its activated form , a phenomenon associated with the malignant phenotype ."
],
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0,
211
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]
}
] | [
{
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{
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},
{
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"type": "progene_text",
"text": [
"STAT3"
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[
127,
132
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],
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}
] | [] | [] | [] |
split_0_train_29797 | split_0_train_29797 | [
{
"id": "split_0_train_29797_passage",
"type": "progene_text",
"text": [
"Mandibuloacral dysplasia is caused by a mutation in LMNA - encoding lamin A / C ."
],
"offsets": [
[
0,
81
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]
}
] | [
{
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52,
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{
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"text": [
"lamin A / C"
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[
68,
79
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29798 | split_0_train_29798 | [
{
"id": "split_0_train_29798_passage",
"type": "progene_text",
"text": [
"Mandibuloacral dysplasia ( MAD ) is a rare autosomal recessive disorder , characterized by postnatal growth retardation , craniofacial anomalies , skeletal malformations , and mottled cutaneous pigmentation ."
],
"offsets": [
[
0,
208
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]
}
] | [] | [] | [] | [] |
split_0_train_29799 | split_0_train_29799 | [
{
"id": "split_0_train_29799_passage",
"type": "progene_text",
"text": [
"The LMNA gene encoding two nuclear envelope proteins ( lamins A and C [ lamin A/C ] ) maps to chromosome 1q21 and has been associated with five distinct pathologies , including Dunnigan - type familial partial lipodystrophy , a condition that is characterized by subcutaneous fat loss and is invariably associated with insulin resistance and diabetes ."
],
"offsets": [
[
0,
352
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]
}
] | [
{
"id": "split_0_train_47957_entity",
"type": "progene_text",
"text": [
"LMNA"
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[
4,
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},
{
"id": "split_0_train_47958_entity",
"type": "progene_text",
"text": [
"lamins A and C"
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[
55,
69
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},
{
"id": "split_0_train_47959_entity",
"type": "progene_text",
"text": [
"lamin A/C"
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[
72,
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},
{
"id": "split_0_train_47960_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
319,
326
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],
"normalized": []
}
] | [] | [] | [] |
Subsets and Splits