id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_29800 | split_0_train_29800 | [
{
"id": "split_0_train_29800_passage",
"type": "progene_text",
"text": [
"Since patients with MAD frequently have partial lipodystrophy and insulin resistance , we hypothesized that the disease may be caused by mutations in the LMNA gene ."
],
"offsets": [
[
0,
165
]
]
}
] | [
{
"id": "split_0_train_47961_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
66,
73
]
],
"normalized": []
},
{
"id": "split_0_train_47962_entity",
"type": "progene_text",
"text": [
"LMNA"
],
"offsets": [
[
154,
158
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29801 | split_0_train_29801 | [
{
"id": "split_0_train_29801_passage",
"type": "progene_text",
"text": [
"We analyzed five consanguineous Italian families and demonstrated linkage of MAD to chromosome 1q21 , by use of homozygosity mapping ."
],
"offsets": [
[
0,
134
]
]
}
] | [] | [] | [] | [] |
split_0_train_29802 | split_0_train_29802 | [
{
"id": "split_0_train_29802_passage",
"type": "progene_text",
"text": [
"We then sequenced the LMNA gene and identified a homozygous missense mutation ( R527H ) that was shared by all affected patients ."
],
"offsets": [
[
0,
130
]
]
}
] | [
{
"id": "split_0_train_47963_entity",
"type": "progene_text",
"text": [
"LMNA"
],
"offsets": [
[
22,
26
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29803 | split_0_train_29803 | [
{
"id": "split_0_train_29803_passage",
"type": "progene_text",
"text": [
"Patient skin fibroblasts showed nuclei that presented abnormal lamin A / C distribution and a dysmorphic envelope , thus demonstrating the pathogenic effect of the R527H LMNA mutation ."
],
"offsets": [
[
0,
185
]
]
}
] | [
{
"id": "split_0_train_47964_entity",
"type": "progene_text",
"text": [
"lamin A / C"
],
"offsets": [
[
63,
74
]
],
"normalized": []
},
{
"id": "split_0_train_47965_entity",
"type": "progene_text",
"text": [
"LMNA"
],
"offsets": [
[
170,
174
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29804 | split_0_train_29804 | [
{
"id": "split_0_train_29804_passage",
"type": "progene_text",
"text": [
"Interaction of p58 ( PITSLRE ) , a G2 / M - specific protein kinase , with cyclin D3 ."
],
"offsets": [
[
0,
86
]
]
}
] | [
{
"id": "split_0_train_47966_entity",
"type": "progene_text",
"text": [
"p58 ( PITSLRE )"
],
"offsets": [
[
15,
30
]
],
"normalized": []
},
{
"id": "split_0_train_47967_entity",
"type": "progene_text",
"text": [
"protein kinase"
],
"offsets": [
[
53,
67
]
],
"normalized": []
},
{
"id": "split_0_train_47968_entity",
"type": "progene_text",
"text": [
"cyclin D3"
],
"offsets": [
[
75,
84
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29805 | split_0_train_29805 | [
{
"id": "split_0_train_29805_passage",
"type": "progene_text",
"text": [
"The p58 ( PITSLRE ) is a p34 ( cdc2 ) - related protein kinase that plays an important role in normal cell cycle progression ."
],
"offsets": [
[
0,
126
]
]
}
] | [
{
"id": "split_0_train_47969_entity",
"type": "progene_text",
"text": [
"p58 ( PITSLRE )"
],
"offsets": [
[
4,
19
]
],
"normalized": []
},
{
"id": "split_0_train_47970_entity",
"type": "progene_text",
"text": [
"p34 ( cdc2 )"
],
"offsets": [
[
25,
37
]
],
"normalized": []
},
{
"id": "split_0_train_47971_entity",
"type": "progene_text",
"text": [
"protein kinase"
],
"offsets": [
[
48,
62
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29806 | split_0_train_29806 | [
{
"id": "split_0_train_29806_passage",
"type": "progene_text",
"text": [
"Elevated expression of p58 ( PITSLRE ) in eukaryotic cells prevents them from undergoing normal cytokinesis and appears to delay them in late telophase ."
],
"offsets": [
[
0,
153
]
]
}
] | [
{
"id": "split_0_train_47972_entity",
"type": "progene_text",
"text": [
"p58 ( PITSLRE )"
],
"offsets": [
[
23,
38
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29807 | split_0_train_29807 | [
{
"id": "split_0_train_29807_passage",
"type": "progene_text",
"text": [
"To investigate the molecular mechanism of p58 ( PITSLRE ) action , we used the yeast two - hybrid system , screened a human fetal liver cDNA library , and identified cyclin D3 as an interacting partner of p58 ( PITSLRE ) ."
],
"offsets": [
[
0,
222
]
]
}
] | [
{
"id": "split_0_train_47973_entity",
"type": "progene_text",
"text": [
"p58 ( PITSLRE )"
],
"offsets": [
[
42,
57
]
],
"normalized": []
},
{
"id": "split_0_train_47974_entity",
"type": "progene_text",
"text": [
"cyclin D3"
],
"offsets": [
[
166,
175
]
],
"normalized": []
},
{
"id": "split_0_train_47975_entity",
"type": "progene_text",
"text": [
"p58 ( PITSLRE )"
],
"offsets": [
[
205,
220
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29808 | split_0_train_29808 | [
{
"id": "split_0_train_29808_passage",
"type": "progene_text",
"text": [
"In vitro binding assay , in vivo coimmunoprecipitation , and immunofluorescence cell staining further confirmed the association of p58 ( PITSLRE ) with cyclin D3 ."
],
"offsets": [
[
0,
163
]
]
}
] | [
{
"id": "split_0_train_47976_entity",
"type": "progene_text",
"text": [
"p58 ( PITSLRE )"
],
"offsets": [
[
131,
146
]
],
"normalized": []
},
{
"id": "split_0_train_47977_entity",
"type": "progene_text",
"text": [
"cyclin D3"
],
"offsets": [
[
152,
161
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29809 | split_0_train_29809 | [
{
"id": "split_0_train_29809_passage",
"type": "progene_text",
"text": [
"This binding was observed only in the G(2) / M phase but not in the G(1) / S phase of the cell cycle ; meanwhile , no interaction between p110 ( PITSLRE ) and cyclin D3 was observed in all the cell cycle ."
],
"offsets": [
[
0,
205
]
]
}
] | [
{
"id": "split_0_train_47978_entity",
"type": "progene_text",
"text": [
"PITSLRE"
],
"offsets": [
[
145,
152
]
],
"normalized": []
},
{
"id": "split_0_train_47979_entity",
"type": "progene_text",
"text": [
"cyclin D3"
],
"offsets": [
[
159,
168
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29810 | split_0_train_29810 | [
{
"id": "split_0_train_29810_passage",
"type": "progene_text",
"text": [
"The overexpression of cyclin D3 in 7721 cells leads to an exclusively accumulation of p58 ( PITSLRE ) in the nuclear region , affecting its cellular distribution ."
],
"offsets": [
[
0,
163
]
]
}
] | [
{
"id": "split_0_train_47980_entity",
"type": "progene_text",
"text": [
"cyclin D3"
],
"offsets": [
[
22,
31
]
],
"normalized": []
},
{
"id": "split_0_train_47981_entity",
"type": "progene_text",
"text": [
"p58 ( PITSLRE )"
],
"offsets": [
[
86,
101
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29811 | split_0_train_29811 | [
{
"id": "split_0_train_29811_passage",
"type": "progene_text",
"text": [
"Histone H1 kinase activity of p58 ( PITSLRE ) was greatly enhanced upon interaction with cyclin D3 ."
],
"offsets": [
[
0,
100
]
]
}
] | [
{
"id": "split_0_train_47982_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
11,
17
]
],
"normalized": []
},
{
"id": "split_0_train_47983_entity",
"type": "progene_text",
"text": [
"p58 ( PITSLRE )"
],
"offsets": [
[
30,
45
]
],
"normalized": []
},
{
"id": "split_0_train_47984_entity",
"type": "progene_text",
"text": [
"cyclin D3"
],
"offsets": [
[
89,
98
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29812 | split_0_train_29812 | [
{
"id": "split_0_train_29812_passage",
"type": "progene_text",
"text": [
"Furthermore , kinase activity of p58 ( PITSLRE ) was found to increase greatly in the presence of cyclin D3 using a specific substrate , beta-1,4-galactosyltransferase 1 ."
],
"offsets": [
[
0,
171
]
]
}
] | [
{
"id": "split_0_train_47985_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
14,
20
]
],
"normalized": []
},
{
"id": "split_0_train_47986_entity",
"type": "progene_text",
"text": [
"p58 ( PITSLRE )"
],
"offsets": [
[
33,
48
]
],
"normalized": []
},
{
"id": "split_0_train_47987_entity",
"type": "progene_text",
"text": [
"cyclin D3"
],
"offsets": [
[
98,
107
]
],
"normalized": []
},
{
"id": "split_0_train_47988_entity",
"type": "progene_text",
"text": [
"beta-1,4-galactosyltransferase 1"
],
"offsets": [
[
137,
169
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29813 | split_0_train_29813 | [
{
"id": "split_0_train_29813_passage",
"type": "progene_text",
"text": [
"These data provide a new clue to our understanding of the cellular function of p58 ( PITSLRE ) and cyclin D3 ."
],
"offsets": [
[
0,
110
]
]
}
] | [
{
"id": "split_0_train_47989_entity",
"type": "progene_text",
"text": [
"p58 ( PITSLRE )"
],
"offsets": [
[
79,
94
]
],
"normalized": []
},
{
"id": "split_0_train_47990_entity",
"type": "progene_text",
"text": [
"cyclin D3"
],
"offsets": [
[
99,
108
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29814 | split_0_train_29814 | [
{
"id": "split_0_train_29814_passage",
"type": "progene_text",
"text": [
"Expression of the leucocyte common antigen - related ( LAR ) tyrosine phosphatase is regulated by cell density through functional E-cadherin complexes ."
],
"offsets": [
[
0,
152
]
]
}
] | [
{
"id": "split_0_train_47991_entity",
"type": "progene_text",
"text": [
"leucocyte common antigen - related ( LAR ) tyrosine phosphatase"
],
"offsets": [
[
18,
81
]
],
"normalized": []
},
{
"id": "split_0_train_47992_entity",
"type": "progene_text",
"text": [
"E-cadherin"
],
"offsets": [
[
130,
140
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29815 | split_0_train_29815 | [
{
"id": "split_0_train_29815_passage",
"type": "progene_text",
"text": [
"The leucocyte common antigen - related phosphatase ( LAR ) has been implicated in receptor tyrosine kinase signalling pathways while also displaying cell - density - dependency and localization to adherens junctions ."
],
"offsets": [
[
0,
217
]
]
}
] | [
{
"id": "split_0_train_47993_entity",
"type": "progene_text",
"text": [
"leucocyte common antigen - related phosphatase"
],
"offsets": [
[
4,
50
]
],
"normalized": []
},
{
"id": "split_0_train_47994_entity",
"type": "progene_text",
"text": [
"LAR"
],
"offsets": [
[
53,
56
]
],
"normalized": []
},
{
"id": "split_0_train_47995_entity",
"type": "progene_text",
"text": [
"receptor tyrosine kinase"
],
"offsets": [
[
82,
106
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29816 | split_0_train_29816 | [
{
"id": "split_0_train_29816_passage",
"type": "progene_text",
"text": [
"Whereas physiological substrates for LAR have not been identified unequivocally , beta-catenin associates with LAR and is a substrate in vitro ."
],
"offsets": [
[
0,
144
]
]
}
] | [
{
"id": "split_0_train_47996_entity",
"type": "progene_text",
"text": [
"LAR"
],
"offsets": [
[
37,
40
]
],
"normalized": []
},
{
"id": "split_0_train_47997_entity",
"type": "progene_text",
"text": [
"beta-catenin"
],
"offsets": [
[
82,
94
]
],
"normalized": []
},
{
"id": "split_0_train_47998_entity",
"type": "progene_text",
"text": [
"LAR"
],
"offsets": [
[
111,
114
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29817 | split_0_train_29817 | [
{
"id": "split_0_train_29817_passage",
"type": "progene_text",
"text": [
"With the implication that LAR may play a role in regulating E-cadherin - dependent cell - cell communication and contact inhibition , the relationship of LAR with E-cadherin was investigated ."
],
"offsets": [
[
0,
192
]
]
}
] | [
{
"id": "split_0_train_47999_entity",
"type": "progene_text",
"text": [
"LAR"
],
"offsets": [
[
26,
29
]
],
"normalized": []
},
{
"id": "split_0_train_48000_entity",
"type": "progene_text",
"text": [
"E-cadherin"
],
"offsets": [
[
60,
70
]
],
"normalized": []
},
{
"id": "split_0_train_48001_entity",
"type": "progene_text",
"text": [
"LAR"
],
"offsets": [
[
154,
157
]
],
"normalized": []
},
{
"id": "split_0_train_48002_entity",
"type": "progene_text",
"text": [
"E-cadherin"
],
"offsets": [
[
163,
173
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29818 | split_0_train_29818 | [
{
"id": "split_0_train_29818_passage",
"type": "progene_text",
"text": [
"LAR expression increased with cell density in the human breast cancer cell line MCF-7 and in Ln 3 cells derived from the 13762NF rat mammary adenocarcinoma ."
],
"offsets": [
[
0,
157
]
]
}
] | [
{
"id": "split_0_train_48003_entity",
"type": "progene_text",
"text": [
"LAR"
],
"offsets": [
[
0,
3
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29819 | split_0_train_29819 | [
{
"id": "split_0_train_29819_passage",
"type": "progene_text",
"text": [
"LAR protein levels decreased rapidly when cells were replated at a low density after attaining high expression of LAR at high cell density ."
],
"offsets": [
[
0,
140
]
]
}
] | [
{
"id": "split_0_train_48004_entity",
"type": "progene_text",
"text": [
"LAR"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_48005_entity",
"type": "progene_text",
"text": [
"LAR"
],
"offsets": [
[
114,
117
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29820 | split_0_train_29820 | [
{
"id": "split_0_train_29820_passage",
"type": "progene_text",
"text": [
"COS-7 cells displayed comparable density - dependent regulation of LAR expression when transiently expressing exogenous LAR under the control of a constitutively active promoter , indicating that the regulation of expression is not at the level of gene regulation ."
],
"offsets": [
[
0,
265
]
]
}
] | [
{
"id": "split_0_train_48006_entity",
"type": "progene_text",
"text": [
"LAR"
],
"offsets": [
[
67,
70
]
],
"normalized": []
},
{
"id": "split_0_train_48007_entity",
"type": "progene_text",
"text": [
"LAR"
],
"offsets": [
[
120,
123
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29821 | split_0_train_29821 | [
{
"id": "split_0_train_29821_passage",
"type": "progene_text",
"text": [
"Disrupting homophilic E-cadherin complexes by chelating extracellular calcium caused a marked decrease in LAR protein levels ."
],
"offsets": [
[
0,
126
]
]
}
] | [
{
"id": "split_0_train_48008_entity",
"type": "progene_text",
"text": [
"E-cadherin"
],
"offsets": [
[
22,
32
]
],
"normalized": []
},
{
"id": "split_0_train_48009_entity",
"type": "progene_text",
"text": [
"LAR"
],
"offsets": [
[
106,
109
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29822 | split_0_train_29822 | [
{
"id": "split_0_train_29822_passage",
"type": "progene_text",
"text": [
"Similarly , blocking E-cadherin interactions with saturating amounts of E-cadherin antibody ( HECD-1 ) also led to a rapid and pronounced loss of cellular LAR ."
],
"offsets": [
[
0,
160
]
]
}
] | [
{
"id": "split_0_train_48010_entity",
"type": "progene_text",
"text": [
"E-cadherin"
],
"offsets": [
[
21,
31
]
],
"normalized": []
},
{
"id": "split_0_train_48011_entity",
"type": "progene_text",
"text": [
"E-cadherin"
],
"offsets": [
[
72,
82
]
],
"normalized": []
},
{
"id": "split_0_train_48012_entity",
"type": "progene_text",
"text": [
"LAR"
],
"offsets": [
[
155,
158
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29823 | split_0_train_29823 | [
{
"id": "split_0_train_29823_passage",
"type": "progene_text",
"text": [
"In contrast , mimicking cell - surface E-cadherin engagement by plating cells at low density on to dishes coated with HECD-1 resulted in a 2 - fold increase in LAR expression compared with controls ."
],
"offsets": [
[
0,
199
]
]
}
] | [
{
"id": "split_0_train_48013_entity",
"type": "progene_text",
"text": [
"E-cadherin"
],
"offsets": [
[
39,
49
]
],
"normalized": []
},
{
"id": "split_0_train_48014_entity",
"type": "progene_text",
"text": [
"LAR"
],
"offsets": [
[
160,
163
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29824 | split_0_train_29824 | [
{
"id": "split_0_train_29824_passage",
"type": "progene_text",
"text": [
"These results suggest that density - dependent regulation of LAR expression is mediated by functional E-cadherin and may play a role in density - dependent contact inhibition by regulating tyrosine phosphorylation in E-cadherin complexes ."
],
"offsets": [
[
0,
239
]
]
}
] | [
{
"id": "split_0_train_48015_entity",
"type": "progene_text",
"text": [
"LAR"
],
"offsets": [
[
61,
64
]
],
"normalized": []
},
{
"id": "split_0_train_48016_entity",
"type": "progene_text",
"text": [
"E-cadherin"
],
"offsets": [
[
102,
112
]
],
"normalized": []
},
{
"id": "split_0_train_48017_entity",
"type": "progene_text",
"text": [
"E-cadherin"
],
"offsets": [
[
217,
227
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29825 | split_0_train_29825 | [
{
"id": "split_0_train_29825_passage",
"type": "progene_text",
"text": [
"The transcriptional regulating protein of 132 kDa ( TReP-132 ) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells ."
],
"offsets": [
[
0,
171
]
]
}
] | [
{
"id": "split_0_train_48018_entity",
"type": "progene_text",
"text": [
"transcriptional regulating protein of 132 kDa"
],
"offsets": [
[
4,
49
]
],
"normalized": []
},
{
"id": "split_0_train_48019_entity",
"type": "progene_text",
"text": [
"TReP-132"
],
"offsets": [
[
52,
60
]
],
"normalized": []
},
{
"id": "split_0_train_48020_entity",
"type": "progene_text",
"text": [
"P450scc"
],
"offsets": [
[
72,
79
]
],
"normalized": []
},
{
"id": "split_0_train_48021_entity",
"type": "progene_text",
"text": [
"steroidogenic factor-1"
],
"offsets": [
[
124,
146
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29826 | split_0_train_29826 | [
{
"id": "split_0_train_29826_passage",
"type": "progene_text",
"text": [
"The human P450scc gene is regulated by the tissue - specific orphan nuclear receptor , steroidogenic factor-1 ( SF-1 ) , which plays a key role in several physiologic processes including steroid synthesis , adrenal and gonadal development , and sexual differentiation ."
],
"offsets": [
[
0,
269
]
]
}
] | [
{
"id": "split_0_train_48022_entity",
"type": "progene_text",
"text": [
"P450scc"
],
"offsets": [
[
10,
17
]
],
"normalized": []
},
{
"id": "split_0_train_48023_entity",
"type": "progene_text",
"text": [
"steroidogenic factor-1"
],
"offsets": [
[
87,
109
]
],
"normalized": []
},
{
"id": "split_0_train_48024_entity",
"type": "progene_text",
"text": [
"SF-1"
],
"offsets": [
[
112,
116
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29827 | split_0_train_29827 | [
{
"id": "split_0_train_29827_passage",
"type": "progene_text",
"text": [
"Several studies have demonstrated the interaction of SF-1 with different proteins ."
],
"offsets": [
[
0,
83
]
]
}
] | [
{
"id": "split_0_train_48025_entity",
"type": "progene_text",
"text": [
"SF-1"
],
"offsets": [
[
53,
57
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29828 | split_0_train_29828 | [
{
"id": "split_0_train_29828_passage",
"type": "progene_text",
"text": [
"However , it is clear that additional factors not yet identified are involved with SF-1 to regulate different target genes ."
],
"offsets": [
[
0,
124
]
]
}
] | [
{
"id": "split_0_train_48026_entity",
"type": "progene_text",
"text": [
"SF-1"
],
"offsets": [
[
83,
87
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29829 | split_0_train_29829 | [
{
"id": "split_0_train_29829_passage",
"type": "progene_text",
"text": [
"Recently , it was demonstrated that a novel transcriptional regulating protein of 132 kDa ( TReP-132 ) regulates expression of the human P450scc gene ."
],
"offsets": [
[
0,
151
]
]
}
] | [
{
"id": "split_0_train_48027_entity",
"type": "progene_text",
"text": [
"transcriptional regulating protein of 132 kDa"
],
"offsets": [
[
44,
89
]
],
"normalized": []
},
{
"id": "split_0_train_48028_entity",
"type": "progene_text",
"text": [
"TReP-132"
],
"offsets": [
[
92,
100
]
],
"normalized": []
},
{
"id": "split_0_train_48029_entity",
"type": "progene_text",
"text": [
"P450scc"
],
"offsets": [
[
137,
144
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29830 | split_0_train_29830 | [
{
"id": "split_0_train_29830_passage",
"type": "progene_text",
"text": [
"The overexpression of TReP-132 in adrenal cells increases the production of pregnenolone , which is associated with the activation of P450scc gene expression ."
],
"offsets": [
[
0,
159
]
]
}
] | [
{
"id": "split_0_train_48030_entity",
"type": "progene_text",
"text": [
"TReP-132"
],
"offsets": [
[
22,
30
]
],
"normalized": []
},
{
"id": "split_0_train_48031_entity",
"type": "progene_text",
"text": [
"P450scc"
],
"offsets": [
[
134,
141
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29831 | split_0_train_29831 | [
{
"id": "split_0_train_29831_passage",
"type": "progene_text",
"text": [
"Considering the colocalization of TReP-132 and SF-1 in steroidogenic tissues such as the adrenal and testis , and the presence of two putative LXXLL motifs in TReP-132 that can potentially interact with SF-1 , the relationship between these two factors on the P450scc gene promoter was determined ."
],
"offsets": [
[
0,
298
]
]
}
] | [
{
"id": "split_0_train_48032_entity",
"type": "progene_text",
"text": [
"TReP-132"
],
"offsets": [
[
34,
42
]
],
"normalized": []
},
{
"id": "split_0_train_48033_entity",
"type": "progene_text",
"text": [
"SF-1"
],
"offsets": [
[
47,
51
]
],
"normalized": []
},
{
"id": "split_0_train_48034_entity",
"type": "progene_text",
"text": [
"TReP-132"
],
"offsets": [
[
159,
167
]
],
"normalized": []
},
{
"id": "split_0_train_48035_entity",
"type": "progene_text",
"text": [
"SF-1"
],
"offsets": [
[
203,
207
]
],
"normalized": []
},
{
"id": "split_0_train_48036_entity",
"type": "progene_text",
"text": [
"P450scc"
],
"offsets": [
[
260,
267
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29832 | split_0_train_29832 | [
{
"id": "split_0_train_29832_passage",
"type": "progene_text",
"text": [
"The coexpression of SF-1 and TReP-132 in adrenal NCI-H295 cells cooperates to increase promoter activity ."
],
"offsets": [
[
0,
106
]
]
}
] | [
{
"id": "split_0_train_48037_entity",
"type": "progene_text",
"text": [
"SF-1"
],
"offsets": [
[
20,
24
]
],
"normalized": []
},
{
"id": "split_0_train_48038_entity",
"type": "progene_text",
"text": [
"TReP-132"
],
"offsets": [
[
29,
37
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29833 | split_0_train_29833 | [
{
"id": "split_0_train_29833_passage",
"type": "progene_text",
"text": [
"Pull - down experiments demonstrated the interaction between TReP-132 and SF-1 , and this was further confirmed in intact cells by coimmunoprecipitation / Western blot and two - hybrid analyses ."
],
"offsets": [
[
0,
195
]
]
}
] | [
{
"id": "split_0_train_48039_entity",
"type": "progene_text",
"text": [
"TReP-132"
],
"offsets": [
[
61,
69
]
],
"normalized": []
},
{
"id": "split_0_train_48040_entity",
"type": "progene_text",
"text": [
"SF-1"
],
"offsets": [
[
74,
78
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29834 | split_0_train_29834 | [
{
"id": "split_0_train_29834_passage",
"type": "progene_text",
"text": [
"Deletions and mutations of the TReP-132 cDNA sequence demonstrate that SF-1 interaction requires the LXXLL motif found at the amino - terminal region of the protein ."
],
"offsets": [
[
0,
166
]
]
}
] | [
{
"id": "split_0_train_48041_entity",
"type": "progene_text",
"text": [
"TReP-132"
],
"offsets": [
[
31,
39
]
],
"normalized": []
},
{
"id": "split_0_train_48042_entity",
"type": "progene_text",
"text": [
"SF-1"
],
"offsets": [
[
71,
75
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29835 | split_0_train_29835 | [
{
"id": "split_0_train_29835_passage",
"type": "progene_text",
"text": [
"Also , the \" proximal activation domain \" and the \" AF-2 hexamer \" motif of SF-1 are involved in interaction with TReP-132 ."
],
"offsets": [
[
0,
124
]
]
}
] | [
{
"id": "split_0_train_48043_entity",
"type": "progene_text",
"text": [
"SF-1"
],
"offsets": [
[
76,
80
]
],
"normalized": []
},
{
"id": "split_0_train_48044_entity",
"type": "progene_text",
"text": [
"TReP-132"
],
"offsets": [
[
114,
122
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29836 | split_0_train_29836 | [
{
"id": "split_0_train_29836_passage",
"type": "progene_text",
"text": [
"Consistent with previous studies showing interaction between CBP / p300 and SF-1 or TReP-132 , the coexpression of these three proteins results in a synergistic effect on P450scc gene promoter activity ."
],
"offsets": [
[
0,
203
]
]
}
] | [
{
"id": "split_0_train_48045_entity",
"type": "progene_text",
"text": [
"CBP"
],
"offsets": [
[
61,
64
]
],
"normalized": []
},
{
"id": "split_0_train_48046_entity",
"type": "progene_text",
"text": [
"p300"
],
"offsets": [
[
67,
71
]
],
"normalized": []
},
{
"id": "split_0_train_48047_entity",
"type": "progene_text",
"text": [
"SF-1"
],
"offsets": [
[
76,
80
]
],
"normalized": []
},
{
"id": "split_0_train_48048_entity",
"type": "progene_text",
"text": [
"TReP-132"
],
"offsets": [
[
84,
92
]
],
"normalized": []
},
{
"id": "split_0_train_48049_entity",
"type": "progene_text",
"text": [
"P450scc"
],
"offsets": [
[
171,
178
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29837 | split_0_train_29837 | [
{
"id": "split_0_train_29837_passage",
"type": "progene_text",
"text": [
"Taken together the results in this study identify a novel function of TReP-132 as a partner in a complex with SF-1 and CBP / p300 to regulate gene transcription involved in steroidogenesis ."
],
"offsets": [
[
0,
190
]
]
}
] | [
{
"id": "split_0_train_48050_entity",
"type": "progene_text",
"text": [
"TReP-132"
],
"offsets": [
[
70,
78
]
],
"normalized": []
},
{
"id": "split_0_train_48051_entity",
"type": "progene_text",
"text": [
"SF-1"
],
"offsets": [
[
110,
114
]
],
"normalized": []
},
{
"id": "split_0_train_48052_entity",
"type": "progene_text",
"text": [
"CBP"
],
"offsets": [
[
119,
122
]
],
"normalized": []
},
{
"id": "split_0_train_48053_entity",
"type": "progene_text",
"text": [
"p300"
],
"offsets": [
[
125,
129
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29838 | split_0_train_29838 | [
{
"id": "split_0_train_29838_passage",
"type": "progene_text",
"text": [
"HIV-1 Tat interaction with RNA polymerase II C - terminal domain ( CTD ) and a dynamic association with CDK2 induce CTD phosphorylation and transcription from HIV-1 promoter ."
],
"offsets": [
[
0,
175
]
]
}
] | [
{
"id": "split_0_train_48054_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
6,
9
]
],
"normalized": []
},
{
"id": "split_0_train_48055_entity",
"type": "progene_text",
"text": [
"RNA polymerase II"
],
"offsets": [
[
27,
44
]
],
"normalized": []
},
{
"id": "split_0_train_48056_entity",
"type": "progene_text",
"text": [
"CDK2"
],
"offsets": [
[
104,
108
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29839 | split_0_train_29839 | [
{
"id": "split_0_train_29839_passage",
"type": "progene_text",
"text": [
"Human immunodeficiency virus , type 1 ( HIV-1 ) , Tat protein activates viral gene expression through promoting transcriptional elongation by RNA polymerase II ( RNAPII ) ."
],
"offsets": [
[
0,
172
]
]
}
] | [
{
"id": "split_0_train_48057_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
50,
53
]
],
"normalized": []
},
{
"id": "split_0_train_48058_entity",
"type": "progene_text",
"text": [
"RNA polymerase II"
],
"offsets": [
[
142,
159
]
],
"normalized": []
},
{
"id": "split_0_train_48059_entity",
"type": "progene_text",
"text": [
"RNAPII"
],
"offsets": [
[
162,
168
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29840 | split_0_train_29840 | [
{
"id": "split_0_train_29840_passage",
"type": "progene_text",
"text": [
"In this process Tat enhances phosphorylation of the C - terminal domain ( CTD ) of RNAPII by activating cell cycle - dependent kinases ( CDKs ) associated with general transcription factors of the promoter complex , specifically CDK7 and CDK9 ."
],
"offsets": [
[
0,
244
]
]
}
] | [
{
"id": "split_0_train_48060_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
16,
19
]
],
"normalized": []
},
{
"id": "split_0_train_48061_entity",
"type": "progene_text",
"text": [
"RNAPII"
],
"offsets": [
[
83,
89
]
],
"normalized": []
},
{
"id": "split_0_train_48062_entity",
"type": "progene_text",
"text": [
"cell cycle - dependent kinases"
],
"offsets": [
[
104,
134
]
],
"normalized": []
},
{
"id": "split_0_train_48063_entity",
"type": "progene_text",
"text": [
"CDKs"
],
"offsets": [
[
137,
141
]
],
"normalized": []
},
{
"id": "split_0_train_48064_entity",
"type": "progene_text",
"text": [
"transcription factors"
],
"offsets": [
[
168,
189
]
],
"normalized": []
},
{
"id": "split_0_train_48065_entity",
"type": "progene_text",
"text": [
"CDK7"
],
"offsets": [
[
229,
233
]
],
"normalized": []
},
{
"id": "split_0_train_48066_entity",
"type": "progene_text",
"text": [
"CDK9"
],
"offsets": [
[
238,
242
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29841 | split_0_train_29841 | [
{
"id": "split_0_train_29841_passage",
"type": "progene_text",
"text": [
"We reported a Tat - associated T-cell - derived kinase , which contained CDK2 ."
],
"offsets": [
[
0,
79
]
]
}
] | [
{
"id": "split_0_train_48067_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
14,
17
]
],
"normalized": []
},
{
"id": "split_0_train_48068_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
48,
54
]
],
"normalized": []
},
{
"id": "split_0_train_48069_entity",
"type": "progene_text",
"text": [
"CDK2"
],
"offsets": [
[
73,
77
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29842 | split_0_train_29842 | [
{
"id": "split_0_train_29842_passage",
"type": "progene_text",
"text": [
"Here , we provide further evidence that CDK2 is involved in Tat - mediated CTD phosphorylation and in HIV-1 transcription in vitro ."
],
"offsets": [
[
0,
132
]
]
}
] | [
{
"id": "split_0_train_48070_entity",
"type": "progene_text",
"text": [
"CDK2"
],
"offsets": [
[
40,
44
]
],
"normalized": []
},
{
"id": "split_0_train_48071_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
60,
63
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29843 | split_0_train_29843 | [
{
"id": "split_0_train_29843_passage",
"type": "progene_text",
"text": [
"Tat - mediated CTD phosphorylation by CDK2 required cysteine 22 in the activation domain of Tat and amino acids 42 - 72 of Tat ."
],
"offsets": [
[
0,
128
]
]
}
] | [
{
"id": "split_0_train_48072_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_48073_entity",
"type": "progene_text",
"text": [
"CDK2"
],
"offsets": [
[
38,
42
]
],
"normalized": []
},
{
"id": "split_0_train_48074_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
92,
95
]
],
"normalized": []
},
{
"id": "split_0_train_48075_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
123,
126
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29844 | split_0_train_29844 | [
{
"id": "split_0_train_29844_passage",
"type": "progene_text",
"text": [
"CDK2 phosphorylated Tat itself , apparently by forming dynamic contacts with amino acids 15 - 24 and 36 - 49 of Tat ."
],
"offsets": [
[
0,
117
]
]
}
] | [
{
"id": "split_0_train_48076_entity",
"type": "progene_text",
"text": [
"CDK2"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_48077_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
20,
23
]
],
"normalized": []
},
{
"id": "split_0_train_48078_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
112,
115
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29845 | split_0_train_29845 | [
{
"id": "split_0_train_29845_passage",
"type": "progene_text",
"text": [
"Also , amino acids 24 - 36 and 45 - 72 of Tat interacted with CTD ."
],
"offsets": [
[
0,
67
]
]
}
] | [
{
"id": "split_0_train_48079_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
42,
45
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29846 | split_0_train_29846 | [
{
"id": "split_0_train_29846_passage",
"type": "progene_text",
"text": [
"CDK2 associated with RNAPII and was found in elongation complexes assembled on HIV-1 long - terminal repeat template ."
],
"offsets": [
[
0,
118
]
]
}
] | [
{
"id": "split_0_train_48080_entity",
"type": "progene_text",
"text": [
"CDK2"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_48081_entity",
"type": "progene_text",
"text": [
"RNAPII"
],
"offsets": [
[
21,
27
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29847 | split_0_train_29847 | [
{
"id": "split_0_train_29847_passage",
"type": "progene_text",
"text": [
"Recombinant CDK2 / cyclin E stimulated Tat - dependent HIV-1 transcription in reconstituted transcription assay ."
],
"offsets": [
[
0,
113
]
]
}
] | [
{
"id": "split_0_train_48082_entity",
"type": "progene_text",
"text": [
"CDK2"
],
"offsets": [
[
12,
16
]
],
"normalized": []
},
{
"id": "split_0_train_48083_entity",
"type": "progene_text",
"text": [
"cyclin E"
],
"offsets": [
[
19,
27
]
],
"normalized": []
},
{
"id": "split_0_train_48084_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
39,
42
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29848 | split_0_train_29848 | [
{
"id": "split_0_train_29848_passage",
"type": "progene_text",
"text": [
"Immunodepletion of CDK2 / cyclin E in HeLa nuclear extract blocked Tat - dependent transcription ."
],
"offsets": [
[
0,
98
]
]
}
] | [
{
"id": "split_0_train_48085_entity",
"type": "progene_text",
"text": [
"CDK2"
],
"offsets": [
[
19,
23
]
],
"normalized": []
},
{
"id": "split_0_train_48086_entity",
"type": "progene_text",
"text": [
"cyclin E"
],
"offsets": [
[
26,
34
]
],
"normalized": []
},
{
"id": "split_0_train_48087_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
67,
70
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29849 | split_0_train_29849 | [
{
"id": "split_0_train_29849_passage",
"type": "progene_text",
"text": [
"We suggest that CDK2 is part of a transcription complex that is required for Tat - dependent transcription and that interaction of Tat with CTD and a dynamic association of Tat with CDK2 / cyclin E stimulated CTD phosphorylation by CDK2 ."
],
"offsets": [
[
0,
238
]
]
}
] | [
{
"id": "split_0_train_48088_entity",
"type": "progene_text",
"text": [
"CDK2"
],
"offsets": [
[
16,
20
]
],
"normalized": []
},
{
"id": "split_0_train_48089_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
77,
80
]
],
"normalized": []
},
{
"id": "split_0_train_48090_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
131,
134
]
],
"normalized": []
},
{
"id": "split_0_train_48091_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
173,
176
]
],
"normalized": []
},
{
"id": "split_0_train_48092_entity",
"type": "progene_text",
"text": [
"CDK2"
],
"offsets": [
[
182,
186
]
],
"normalized": []
},
{
"id": "split_0_train_48093_entity",
"type": "progene_text",
"text": [
"cyclin E"
],
"offsets": [
[
189,
197
]
],
"normalized": []
},
{
"id": "split_0_train_48094_entity",
"type": "progene_text",
"text": [
"CDK2"
],
"offsets": [
[
232,
236
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29850 | split_0_train_29850 | [
{
"id": "split_0_train_29850_passage",
"type": "progene_text",
"text": [
"A bimolecular mechanism of HIV-1 Tat protein interaction with RNA polymerase II transcription elongation complexes ."
],
"offsets": [
[
0,
116
]
]
}
] | [
{
"id": "split_0_train_48095_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
33,
36
]
],
"normalized": []
},
{
"id": "split_0_train_48096_entity",
"type": "progene_text",
"text": [
"RNA polymerase II"
],
"offsets": [
[
62,
79
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29851 | split_0_train_29851 | [
{
"id": "split_0_train_29851_passage",
"type": "progene_text",
"text": [
"Transcriptional activation of the human immunodeficiency virus type 1 ( HIV-1 ) long terminal repeat ( LTR ) promoter element is regulated by the essential viral Tat protein that binds to the viral TAR RNA target and recruits a positive transcription elongation complex ( P - TEFb ) ."
],
"offsets": [
[
0,
284
]
]
}
] | [
{
"id": "split_0_train_48097_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
162,
165
]
],
"normalized": []
},
{
"id": "split_0_train_48098_entity",
"type": "progene_text",
"text": [
"positive transcription elongation complex"
],
"offsets": [
[
228,
269
]
],
"normalized": []
},
{
"id": "split_0_train_48099_entity",
"type": "progene_text",
"text": [
"P - TEFb"
],
"offsets": [
[
272,
280
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29852 | split_0_train_29852 | [
{
"id": "split_0_train_29852_passage",
"type": "progene_text",
"text": [
"We have used a stepwise transcription approach and a highly sensitive assay to determine the dynamics of interactions between HIV-1 Tat and the transcription complexes actively engaged in elongation ."
],
"offsets": [
[
0,
200
]
]
}
] | [
{
"id": "split_0_train_48100_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
132,
135
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29853 | split_0_train_29853 | [
{
"id": "split_0_train_29853_passage",
"type": "progene_text",
"text": [
"Our results demonstrate that Tat protein associates with RNA polymerase II complexes during early transcription elongation after the promoter clearance and before the synthesis of full - length TAR RNA transcript ."
],
"offsets": [
[
0,
214
]
]
}
] | [
{
"id": "split_0_train_48101_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
29,
32
]
],
"normalized": []
},
{
"id": "split_0_train_48102_entity",
"type": "progene_text",
"text": [
"RNA polymerase II"
],
"offsets": [
[
57,
74
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29854 | split_0_train_29854 | [
{
"id": "split_0_train_29854_passage",
"type": "progene_text",
"text": [
"This interaction of Tat with RNA polymerase II elongation complexes is P-TEFb - independent ."
],
"offsets": [
[
0,
93
]
]
}
] | [
{
"id": "split_0_train_48103_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
20,
23
]
],
"normalized": []
},
{
"id": "split_0_train_48104_entity",
"type": "progene_text",
"text": [
"RNA polymerase II"
],
"offsets": [
[
29,
46
]
],
"normalized": []
},
{
"id": "split_0_train_48105_entity",
"type": "progene_text",
"text": [
"P-TEFb"
],
"offsets": [
[
71,
77
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29855 | split_0_train_29855 | [
{
"id": "split_0_train_29855_passage",
"type": "progene_text",
"text": [
"Our results also show that there are two Tat binding sites on each transcription elongation complex ; one is located on TAR RNA and the other one on RNA polymerase II near the exit site for nascent mRNA transcripts ."
],
"offsets": [
[
0,
216
]
]
}
] | [
{
"id": "split_0_train_48106_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
41,
44
]
],
"normalized": []
},
{
"id": "split_0_train_48107_entity",
"type": "progene_text",
"text": [
"RNA polymerase II"
],
"offsets": [
[
149,
166
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29856 | split_0_train_29856 | [
{
"id": "split_0_train_29856_passage",
"type": "progene_text",
"text": [
"These findings suggest that two Tat molecules are involved in performing various functions during a single round of HIV-1 mRNA synthesis ."
],
"offsets": [
[
0,
138
]
]
}
] | [
{
"id": "split_0_train_48108_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
32,
35
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29857 | split_0_train_29857 | [
{
"id": "split_0_train_29857_passage",
"type": "progene_text",
"text": [
"QM , a putative tumor suppressor , regulates proto - oncogene c-yes ."
],
"offsets": [
[
0,
69
]
]
}
] | [
{
"id": "split_0_train_48109_entity",
"type": "progene_text",
"text": [
"QM"
],
"offsets": [
[
0,
2
]
],
"normalized": []
},
{
"id": "split_0_train_48110_entity",
"type": "progene_text",
"text": [
"c-yes"
],
"offsets": [
[
62,
67
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29858 | split_0_train_29858 | [
{
"id": "split_0_train_29858_passage",
"type": "progene_text",
"text": [
"The QM gene encodes a 24.5 kDa ribosomal protein L10 known to be highly homologous to a Jun - binding protein ( Jif-1 ) , which inhibits the formation of Jun - Jun dimers ."
],
"offsets": [
[
0,
172
]
]
}
] | [
{
"id": "split_0_train_48111_entity",
"type": "progene_text",
"text": [
"QM"
],
"offsets": [
[
4,
6
]
],
"normalized": []
},
{
"id": "split_0_train_48112_entity",
"type": "progene_text",
"text": [
"ribosomal protein L10"
],
"offsets": [
[
31,
52
]
],
"normalized": []
},
{
"id": "split_0_train_48113_entity",
"type": "progene_text",
"text": [
"Jun"
],
"offsets": [
[
88,
91
]
],
"normalized": []
},
{
"id": "split_0_train_48114_entity",
"type": "progene_text",
"text": [
"Jif-1"
],
"offsets": [
[
112,
117
]
],
"normalized": []
},
{
"id": "split_0_train_48115_entity",
"type": "progene_text",
"text": [
"Jun"
],
"offsets": [
[
154,
157
]
],
"normalized": []
},
{
"id": "split_0_train_48116_entity",
"type": "progene_text",
"text": [
"Jun"
],
"offsets": [
[
160,
163
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29859 | split_0_train_29859 | [
{
"id": "split_0_train_29859_passage",
"type": "progene_text",
"text": [
"Here we have carried out screening with the c-Yes protein and found that a QM homologous protein showed interactions with c-Yes and other Src family members ."
],
"offsets": [
[
0,
158
]
]
}
] | [
{
"id": "split_0_train_48117_entity",
"type": "progene_text",
"text": [
"c-Yes"
],
"offsets": [
[
44,
49
]
],
"normalized": []
},
{
"id": "split_0_train_48118_entity",
"type": "progene_text",
"text": [
"QM"
],
"offsets": [
[
75,
77
]
],
"normalized": []
},
{
"id": "split_0_train_48119_entity",
"type": "progene_text",
"text": [
"c-Yes"
],
"offsets": [
[
122,
127
]
],
"normalized": []
},
{
"id": "split_0_train_48120_entity",
"type": "progene_text",
"text": [
"Src family"
],
"offsets": [
[
138,
148
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29860 | split_0_train_29860 | [
{
"id": "split_0_train_29860_passage",
"type": "progene_text",
"text": [
"We have found that two different regions of QM protein were associated with the SH3 domain of c-Yes ."
],
"offsets": [
[
0,
101
]
]
}
] | [
{
"id": "split_0_train_48121_entity",
"type": "progene_text",
"text": [
"QM"
],
"offsets": [
[
44,
46
]
],
"normalized": []
},
{
"id": "split_0_train_48122_entity",
"type": "progene_text",
"text": [
"c-Yes"
],
"offsets": [
[
94,
99
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29861 | split_0_train_29861 | [
{
"id": "split_0_train_29861_passage",
"type": "progene_text",
"text": [
"The QM protein does not contain canonical SH3 binding motifs or previously reported amino acid fragments showing interaction with SH3 domains ."
],
"offsets": [
[
0,
143
]
]
}
] | [
{
"id": "split_0_train_48123_entity",
"type": "progene_text",
"text": [
"QM"
],
"offsets": [
[
4,
6
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29862 | split_0_train_29862 | [
{
"id": "split_0_train_29862_passage",
"type": "progene_text",
"text": [
"Several c-Yes kinase activity assays indicated that the QM protein reduced c-Yes kinase activity by 70 % and that this suppression is related not only to the two SH3 binding regions but also to the C - terminal region of QM ."
],
"offsets": [
[
0,
225
]
]
}
] | [
{
"id": "split_0_train_48124_entity",
"type": "progene_text",
"text": [
"c-Yes"
],
"offsets": [
[
8,
13
]
],
"normalized": []
},
{
"id": "split_0_train_48125_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
14,
20
]
],
"normalized": []
},
{
"id": "split_0_train_48126_entity",
"type": "progene_text",
"text": [
"QM"
],
"offsets": [
[
56,
58
]
],
"normalized": []
},
{
"id": "split_0_train_48127_entity",
"type": "progene_text",
"text": [
"c-Yes"
],
"offsets": [
[
75,
80
]
],
"normalized": []
},
{
"id": "split_0_train_48128_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
81,
87
]
],
"normalized": []
},
{
"id": "split_0_train_48129_entity",
"type": "progene_text",
"text": [
"QM"
],
"offsets": [
[
221,
223
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29863 | split_0_train_29863 | [
{
"id": "split_0_train_29863_passage",
"type": "progene_text",
"text": [
"Moreover , our autophosphorylation assays clarified that this regulation resulted from the inhibition of c-Yes autophosphorylation ."
],
"offsets": [
[
0,
132
]
]
}
] | [
{
"id": "split_0_train_48130_entity",
"type": "progene_text",
"text": [
"c-Yes"
],
"offsets": [
[
105,
110
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29864 | split_0_train_29864 | [
{
"id": "split_0_train_29864_passage",
"type": "progene_text",
"text": [
"Immunofluorescence studies showed that the QM proteins and c-Yes are able to interact in various tumor cell lines in vivo ."
],
"offsets": [
[
0,
123
]
]
}
] | [
{
"id": "split_0_train_48131_entity",
"type": "progene_text",
"text": [
"QM"
],
"offsets": [
[
43,
45
]
],
"normalized": []
},
{
"id": "split_0_train_48132_entity",
"type": "progene_text",
"text": [
"c-Yes"
],
"offsets": [
[
59,
64
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29865 | split_0_train_29865 | [
{
"id": "split_0_train_29865_passage",
"type": "progene_text",
"text": [
"The increases of the c-Yes protein and mRNA levels were detected when the QM was transfected ."
],
"offsets": [
[
0,
94
]
]
}
] | [
{
"id": "split_0_train_48133_entity",
"type": "progene_text",
"text": [
"c-Yes"
],
"offsets": [
[
21,
26
]
],
"normalized": []
},
{
"id": "split_0_train_48134_entity",
"type": "progene_text",
"text": [
"QM"
],
"offsets": [
[
74,
76
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29866 | split_0_train_29866 | [
{
"id": "split_0_train_29866_passage",
"type": "progene_text",
"text": [
"These results suggest that the QM protein might be a regulator for various signal transduction pathways involving SH3 domain - containing membrane proteins ."
],
"offsets": [
[
0,
157
]
]
}
] | [
{
"id": "split_0_train_48135_entity",
"type": "progene_text",
"text": [
"QM"
],
"offsets": [
[
31,
33
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29867 | split_0_train_29867 | [
{
"id": "split_0_train_29867_passage",
"type": "progene_text",
"text": [
"Induction of homologue of Slimb ubiquitin ligase receptor by mitogen signaling ."
],
"offsets": [
[
0,
80
]
]
}
] | [
{
"id": "split_0_train_48136_entity",
"type": "progene_text",
"text": [
"Slimb"
],
"offsets": [
[
26,
31
]
],
"normalized": []
},
{
"id": "split_0_train_48137_entity",
"type": "progene_text",
"text": [
"ubiquitin ligase"
],
"offsets": [
[
32,
48
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29868 | split_0_train_29868 | [
{
"id": "split_0_train_29868_passage",
"type": "progene_text",
"text": [
"Homologue of Slimb ( HOS ) is the substrate - recognizing component of the SCF(HOS)-Roc1 E3 ubiquitin protein ligase ."
],
"offsets": [
[
0,
118
]
]
}
] | [
{
"id": "split_0_train_48138_entity",
"type": "progene_text",
"text": [
"Homologue of Slimb"
],
"offsets": [
[
0,
18
]
],
"normalized": []
},
{
"id": "split_0_train_48139_entity",
"type": "progene_text",
"text": [
"HOS"
],
"offsets": [
[
21,
24
]
],
"normalized": []
},
{
"id": "split_0_train_48140_entity",
"type": "progene_text",
"text": [
"SCF(HOS)-Roc1 E3 ubiquitin protein ligase"
],
"offsets": [
[
75,
116
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29869 | split_0_train_29869 | [
{
"id": "split_0_train_29869_passage",
"type": "progene_text",
"text": [
"This ligase mediates ubiquitination of the inhibitor of NF-kappaB transcription factor ( IkappaB ) ."
],
"offsets": [
[
0,
100
]
]
}
] | [
{
"id": "split_0_train_48141_entity",
"type": "progene_text",
"text": [
"ligase"
],
"offsets": [
[
5,
11
]
],
"normalized": []
},
{
"id": "split_0_train_48142_entity",
"type": "progene_text",
"text": [
"inhibitor of NF-kappaB"
],
"offsets": [
[
43,
65
]
],
"normalized": []
},
{
"id": "split_0_train_48143_entity",
"type": "progene_text",
"text": [
"transcription factor"
],
"offsets": [
[
66,
86
]
],
"normalized": []
},
{
"id": "split_0_train_48144_entity",
"type": "progene_text",
"text": [
"IkappaB"
],
"offsets": [
[
89,
96
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29870 | split_0_train_29870 | [
{
"id": "split_0_train_29870_passage",
"type": "progene_text",
"text": [
"We have found that HOS is highly expressed in a number of human cancer cell lines ."
],
"offsets": [
[
0,
83
]
]
}
] | [
{
"id": "split_0_train_48145_entity",
"type": "progene_text",
"text": [
"HOS"
],
"offsets": [
[
19,
22
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29871 | split_0_train_29871 | [
{
"id": "split_0_train_29871_passage",
"type": "progene_text",
"text": [
"The rates of the HOS gene transcription as well as HOS mRNA and protein levels were up - regulated in cells treated with mitogens or transfected with the inducers of mitogen - activated protein kinase pathway ."
],
"offsets": [
[
0,
210
]
]
}
] | [
{
"id": "split_0_train_48146_entity",
"type": "progene_text",
"text": [
"HOS"
],
"offsets": [
[
17,
20
]
],
"normalized": []
},
{
"id": "split_0_train_48147_entity",
"type": "progene_text",
"text": [
"HOS"
],
"offsets": [
[
51,
54
]
],
"normalized": []
},
{
"id": "split_0_train_48148_entity",
"type": "progene_text",
"text": [
"mitogen - activated protein kinase"
],
"offsets": [
[
166,
200
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29872 | split_0_train_29872 | [
{
"id": "split_0_train_29872_passage",
"type": "progene_text",
"text": [
"Conversely , mitogen withdrawal strikingly reduced HOS levels during differentiation of mouse myoblasts ."
],
"offsets": [
[
0,
105
]
]
}
] | [
{
"id": "split_0_train_48149_entity",
"type": "progene_text",
"text": [
"HOS"
],
"offsets": [
[
51,
54
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29873 | split_0_train_29873 | [
{
"id": "split_0_train_29873_passage",
"type": "progene_text",
"text": [
"Activators of mitogen - activated protein kinase accelerated IkappaBalpha degradation and increased NF-kappaB transcriptional activity ."
],
"offsets": [
[
0,
136
]
]
}
] | [
{
"id": "split_0_train_48150_entity",
"type": "progene_text",
"text": [
"mitogen - activated protein kinase"
],
"offsets": [
[
14,
48
]
],
"normalized": []
},
{
"id": "split_0_train_48151_entity",
"type": "progene_text",
"text": [
"IkappaBalpha"
],
"offsets": [
[
61,
73
]
],
"normalized": []
},
{
"id": "split_0_train_48152_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
100,
109
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29874 | split_0_train_29874 | [
{
"id": "split_0_train_29874_passage",
"type": "progene_text",
"text": [
"Inhibition of HOS function via expression of dominant negative HOS ( HOS ( DeltaF ) ) initiated mouse myoblast differentiation and prevented Ras - mediated acceleration of IkappaBalpha degradation as well as NF-kappaB trans-activation and transformation of NIH3T3 cells ."
],
"offsets": [
[
0,
271
]
]
}
] | [
{
"id": "split_0_train_48153_entity",
"type": "progene_text",
"text": [
"HOS"
],
"offsets": [
[
14,
17
]
],
"normalized": []
},
{
"id": "split_0_train_48154_entity",
"type": "progene_text",
"text": [
"HOS"
],
"offsets": [
[
63,
66
]
],
"normalized": []
},
{
"id": "split_0_train_48155_entity",
"type": "progene_text",
"text": [
"HOS"
],
"offsets": [
[
69,
72
]
],
"normalized": []
},
{
"id": "split_0_train_48156_entity",
"type": "progene_text",
"text": [
"Ras"
],
"offsets": [
[
141,
144
]
],
"normalized": []
},
{
"id": "split_0_train_48157_entity",
"type": "progene_text",
"text": [
"IkappaBalpha"
],
"offsets": [
[
172,
184
]
],
"normalized": []
},
{
"id": "split_0_train_48158_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
208,
217
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29875 | split_0_train_29875 | [
{
"id": "split_0_train_29875_passage",
"type": "progene_text",
"text": [
"These data link the induction of HOS in proliferating cells with mitogen - signaling - dependent inhibition of cell differentiation and promotion of cell transformation ."
],
"offsets": [
[
0,
170
]
]
}
] | [
{
"id": "split_0_train_48159_entity",
"type": "progene_text",
"text": [
"HOS"
],
"offsets": [
[
33,
36
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29876 | split_0_train_29876 | [
{
"id": "split_0_train_29876_passage",
"type": "progene_text",
"text": [
"Basic fibroblast growth factor : effects on matrix remodeling , receptor expression , and transduction pathway in human periosteal fibroblasts with FGFR2 gene mutation ."
],
"offsets": [
[
0,
169
]
]
}
] | [
{
"id": "split_0_train_48160_entity",
"type": "progene_text",
"text": [
"Basic fibroblast growth factor"
],
"offsets": [
[
0,
30
]
],
"normalized": []
},
{
"id": "split_0_train_48161_entity",
"type": "progene_text",
"text": [
"FGFR2"
],
"offsets": [
[
148,
153
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29877 | split_0_train_29877 | [
{
"id": "split_0_train_29877_passage",
"type": "progene_text",
"text": [
"The Crouzon syndrome , which is associated with fibroblast growth factor receptor ( FGFR2 ) mutations , is characterized by premature fusion of cranial sutures ."
],
"offsets": [
[
0,
161
]
]
}
] | [
{
"id": "split_0_train_48162_entity",
"type": "progene_text",
"text": [
"fibroblast growth factor receptor"
],
"offsets": [
[
48,
81
]
],
"normalized": []
},
{
"id": "split_0_train_48163_entity",
"type": "progene_text",
"text": [
"FGFR2"
],
"offsets": [
[
84,
89
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29878 | split_0_train_29878 | [
{
"id": "split_0_train_29878_passage",
"type": "progene_text",
"text": [
"We used an in vitro model of cultured periosteal fibroblasts from normal subjects and from Crouzon patients with FGFR2 mutation ."
],
"offsets": [
[
0,
129
]
]
}
] | [
{
"id": "split_0_train_48164_entity",
"type": "progene_text",
"text": [
"FGFR2"
],
"offsets": [
[
113,
118
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29879 | split_0_train_29879 | [
{
"id": "split_0_train_29879_passage",
"type": "progene_text",
"text": [
"We analyzed the matrix turnover rate and the effects of adding FGF2 by evaluating fibronectin synthesis and the activity of some proteolytic enzymes ."
],
"offsets": [
[
0,
150
]
]
}
] | [
{
"id": "split_0_train_48165_entity",
"type": "progene_text",
"text": [
"FGF2"
],
"offsets": [
[
63,
67
]
],
"normalized": []
},
{
"id": "split_0_train_48166_entity",
"type": "progene_text",
"text": [
"fibronectin"
],
"offsets": [
[
82,
93
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29880 | split_0_train_29880 | [
{
"id": "split_0_train_29880_passage",
"type": "progene_text",
"text": [
"To assess the role of some FGF signaling molecules involved in FGFR2 regulation , we studied Grb2 tyrosine phosphorylation and the phosphotyrosine proteins associated with Grb2 ."
],
"offsets": [
[
0,
178
]
]
}
] | [
{
"id": "split_0_train_48167_entity",
"type": "progene_text",
"text": [
"FGF"
],
"offsets": [
[
27,
30
]
],
"normalized": []
},
{
"id": "split_0_train_48168_entity",
"type": "progene_text",
"text": [
"FGFR2"
],
"offsets": [
[
63,
68
]
],
"normalized": []
},
{
"id": "split_0_train_48169_entity",
"type": "progene_text",
"text": [
"Grb2"
],
"offsets": [
[
93,
97
]
],
"normalized": []
},
{
"id": "split_0_train_48170_entity",
"type": "progene_text",
"text": [
"Grb2"
],
"offsets": [
[
172,
176
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29881 | split_0_train_29881 | [
{
"id": "split_0_train_29881_passage",
"type": "progene_text",
"text": [
"The iodinate FGF binding assay was performed to quantify FGFR expression ."
],
"offsets": [
[
0,
74
]
]
}
] | [
{
"id": "split_0_train_48171_entity",
"type": "progene_text",
"text": [
"FGF"
],
"offsets": [
[
13,
16
]
],
"normalized": []
},
{
"id": "split_0_train_48172_entity",
"type": "progene_text",
"text": [
"FGFR"
],
"offsets": [
[
57,
61
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29882 | split_0_train_29882 | [
{
"id": "split_0_train_29882_passage",
"type": "progene_text",
"text": [
"Compared with normal fibroblasts , fibronectin synthesis was decreased in Crouzon fibroblasts , and protease activities in cells and medium were enhanced , suggesting that excess fibronectin catabolism is present ."
],
"offsets": [
[
0,
214
]
]
}
] | [
{
"id": "split_0_train_48173_entity",
"type": "progene_text",
"text": [
"fibronectin"
],
"offsets": [
[
35,
46
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29883 | split_0_train_29883 | [
{
"id": "split_0_train_29883_passage",
"type": "progene_text",
"text": [
"Differences were more marked when FGF2 was added ."
],
"offsets": [
[
0,
50
]
]
}
] | [
{
"id": "split_0_train_48174_entity",
"type": "progene_text",
"text": [
"FGF2"
],
"offsets": [
[
34,
38
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29884 | split_0_train_29884 | [
{
"id": "split_0_train_29884_passage",
"type": "progene_text",
"text": [
"Very few phosphoproteins were visible in anti - Grb2 immunoprecipitations from Crouzon fibroblasts , which showed a significant increase in the number of high - affinity and low - affinity FGF2 receptors ."
],
"offsets": [
[
0,
205
]
]
}
] | [
{
"id": "split_0_train_48175_entity",
"type": "progene_text",
"text": [
"Grb2"
],
"offsets": [
[
48,
52
]
],
"normalized": []
},
{
"id": "split_0_train_48176_entity",
"type": "progene_text",
"text": [
"FGF2 receptors"
],
"offsets": [
[
189,
203
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29885 | split_0_train_29885 | [
{
"id": "split_0_train_29885_passage",
"type": "progene_text",
"text": [
"These results suggest that the abnormal genotype and the Crouzon cellular phenotype are related ."
],
"offsets": [
[
0,
97
]
]
}
] | [] | [] | [] | [] |
split_0_train_29886 | split_0_train_29886 | [
{
"id": "split_0_train_29886_passage",
"type": "progene_text",
"text": [
"To compensate the low levels of tyrosine phosphorylation , Crouzon cells might increase the numbers of FGFR2 , thus increasing the cell surface binding sites for FGF2 ."
],
"offsets": [
[
0,
168
]
]
}
] | [
{
"id": "split_0_train_48177_entity",
"type": "progene_text",
"text": [
"FGFR2"
],
"offsets": [
[
103,
108
]
],
"normalized": []
},
{
"id": "split_0_train_48178_entity",
"type": "progene_text",
"text": [
"FGF2"
],
"offsets": [
[
162,
166
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29887 | split_0_train_29887 | [
{
"id": "split_0_train_29887_passage",
"type": "progene_text",
"text": [
"Transcription factor NF-IL6 ( C / EBPbeta ) activates the expression of the mouse MHC class I H2-Kb gene in response to TNF-alpha via the intragenic downstream regulatory element ."
],
"offsets": [
[
0,
180
]
]
}
] | [
{
"id": "split_0_train_48179_entity",
"type": "progene_text",
"text": [
"Transcription factor"
],
"offsets": [
[
0,
20
]
],
"normalized": []
},
{
"id": "split_0_train_48180_entity",
"type": "progene_text",
"text": [
"NF-IL6"
],
"offsets": [
[
21,
27
]
],
"normalized": []
},
{
"id": "split_0_train_48181_entity",
"type": "progene_text",
"text": [
"C / EBPbeta"
],
"offsets": [
[
30,
41
]
],
"normalized": []
},
{
"id": "split_0_train_48182_entity",
"type": "progene_text",
"text": [
"MHC class I"
],
"offsets": [
[
82,
93
]
],
"normalized": []
},
{
"id": "split_0_train_48183_entity",
"type": "progene_text",
"text": [
"H2-Kb"
],
"offsets": [
[
94,
99
]
],
"normalized": []
},
{
"id": "split_0_train_48184_entity",
"type": "progene_text",
"text": [
"TNF-alpha"
],
"offsets": [
[
120,
129
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29888 | split_0_train_29888 | [
{
"id": "split_0_train_29888_passage",
"type": "progene_text",
"text": [
"The 5'-enhancer - deleted genomic construct of the H2-K(b) gene , stably integrated into the genome of L(tk-) fibroblasts , retains full competence to be induced by tumor necrosis factor - alpha ( TNF-alpha ) treatment ."
],
"offsets": [
[
0,
220
]
]
}
] | [
{
"id": "split_0_train_48185_entity",
"type": "progene_text",
"text": [
"H2-K(b)"
],
"offsets": [
[
51,
58
]
],
"normalized": []
},
{
"id": "split_0_train_48186_entity",
"type": "progene_text",
"text": [
"tumor necrosis factor - alpha"
],
"offsets": [
[
165,
194
]
],
"normalized": []
},
{
"id": "split_0_train_48187_entity",
"type": "progene_text",
"text": [
"TNF-alpha"
],
"offsets": [
[
197,
206
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29889 | split_0_train_29889 | [
{
"id": "split_0_train_29889_passage",
"type": "progene_text",
"text": [
"The only defined regulatory region in this construct is the intragenic downstream regulatory element ( H2DRE ) ."
],
"offsets": [
[
0,
112
]
]
}
] | [] | [] | [] | [] |
split_0_train_29890 | split_0_train_29890 | [
{
"id": "split_0_train_29890_passage",
"type": "progene_text",
"text": [
"Computational inspection uncovered two potential NF-IL6 ( C / EBPbeta ) binding motifs within the H2DRE ."
],
"offsets": [
[
0,
105
]
]
}
] | [
{
"id": "split_0_train_48188_entity",
"type": "progene_text",
"text": [
"NF-IL6"
],
"offsets": [
[
49,
55
]
],
"normalized": []
},
{
"id": "split_0_train_48189_entity",
"type": "progene_text",
"text": [
"C / EBPbeta"
],
"offsets": [
[
58,
69
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29891 | split_0_train_29891 | [
{
"id": "split_0_train_29891_passage",
"type": "progene_text",
"text": [
"Chloramphenicol acetyltransferase ( CAT ) reporter gene assay revealed that NF-IL6 is able to elevate transcription from H2DRE ."
],
"offsets": [
[
0,
128
]
]
}
] | [
{
"id": "split_0_train_48190_entity",
"type": "progene_text",
"text": [
"Chloramphenicol acetyltransferase"
],
"offsets": [
[
0,
33
]
],
"normalized": []
},
{
"id": "split_0_train_48191_entity",
"type": "progene_text",
"text": [
"CAT"
],
"offsets": [
[
36,
39
]
],
"normalized": []
},
{
"id": "split_0_train_48192_entity",
"type": "progene_text",
"text": [
"NF-IL6"
],
"offsets": [
[
76,
82
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29892 | split_0_train_29892 | [
{
"id": "split_0_train_29892_passage",
"type": "progene_text",
"text": [
"Moreover , transient transfection of an NF-IL6 expression vector increased both constitutive and TNF-alpha - induced mRNA levels of endogenous H2 class I genes , and transfection of an NF-IL6 dominant negative construct decreased the expression of endogenous H2 class I genes in a dose - dependent manner ."
],
"offsets": [
[
0,
306
]
]
}
] | [
{
"id": "split_0_train_48193_entity",
"type": "progene_text",
"text": [
"NF-IL6"
],
"offsets": [
[
40,
46
]
],
"normalized": []
},
{
"id": "split_0_train_48194_entity",
"type": "progene_text",
"text": [
"TNF-alpha"
],
"offsets": [
[
97,
106
]
],
"normalized": []
},
{
"id": "split_0_train_48195_entity",
"type": "progene_text",
"text": [
"H2 class I"
],
"offsets": [
[
143,
153
]
],
"normalized": []
},
{
"id": "split_0_train_48196_entity",
"type": "progene_text",
"text": [
"NF-IL6"
],
"offsets": [
[
185,
191
]
],
"normalized": []
},
{
"id": "split_0_train_48197_entity",
"type": "progene_text",
"text": [
"H2 class I"
],
"offsets": [
[
259,
269
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29893 | split_0_train_29893 | [
{
"id": "split_0_train_29893_passage",
"type": "progene_text",
"text": [
"Using the electrophoretic mobility shift assay ( EMSA ) and antibody supershift assay , we were able to qualify the two computationally identified NF-IL6 binding motifs as one high - affinity and one low - affinity binding site ."
],
"offsets": [
[
0,
229
]
]
}
] | [
{
"id": "split_0_train_48198_entity",
"type": "progene_text",
"text": [
"NF-IL6"
],
"offsets": [
[
147,
153
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29894 | split_0_train_29894 | [
{
"id": "split_0_train_29894_passage",
"type": "progene_text",
"text": [
"We conclude that the H2-K(b) gene belongs to target genes of the NF-IL6 ( C / EBPbeta ) in the course of the cellular response to TNF-alpha , and we discuss some consequences of this conclusion in a general framework of inducible expression of the H2-K(b) gene ."
],
"offsets": [
[
0,
262
]
]
}
] | [
{
"id": "split_0_train_48199_entity",
"type": "progene_text",
"text": [
"H2-K(b)"
],
"offsets": [
[
21,
28
]
],
"normalized": []
},
{
"id": "split_0_train_48200_entity",
"type": "progene_text",
"text": [
"NF-IL6"
],
"offsets": [
[
65,
71
]
],
"normalized": []
},
{
"id": "split_0_train_48201_entity",
"type": "progene_text",
"text": [
"C / EBPbeta"
],
"offsets": [
[
74,
85
]
],
"normalized": []
},
{
"id": "split_0_train_48202_entity",
"type": "progene_text",
"text": [
"TNF-alpha"
],
"offsets": [
[
130,
139
]
],
"normalized": []
},
{
"id": "split_0_train_48203_entity",
"type": "progene_text",
"text": [
"H2-K(b)"
],
"offsets": [
[
248,
255
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29895 | split_0_train_29895 | [
{
"id": "split_0_train_29895_passage",
"type": "progene_text",
"text": [
"Hypoxia activates beta(1)-integrin via ERK 1 / 2 and p38 MAP kinase in human vascular smooth muscle cells ."
],
"offsets": [
[
0,
107
]
]
}
] | [
{
"id": "split_0_train_48204_entity",
"type": "progene_text",
"text": [
"beta(1)-integrin"
],
"offsets": [
[
18,
34
]
],
"normalized": []
},
{
"id": "split_0_train_48205_entity",
"type": "progene_text",
"text": [
"ERK 1 / 2"
],
"offsets": [
[
39,
48
]
],
"normalized": []
},
{
"id": "split_0_train_48206_entity",
"type": "progene_text",
"text": [
"p38 MAP kinase"
],
"offsets": [
[
53,
67
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_29896 | split_0_train_29896 | [
{
"id": "split_0_train_29896_passage",
"type": "progene_text",
"text": [
"Hypoxia plays an important role in vascular remodeling and directly affects vascular smooth muscle cell ( VSMC ) functions ."
],
"offsets": [
[
0,
124
]
]
}
] | [] | [] | [] | [] |
split_0_train_29897 | split_0_train_29897 | [
{
"id": "split_0_train_29897_passage",
"type": "progene_text",
"text": [
"VSMC adhesion participates in changes of vascular structure ; however , little is known about VSMC adhesion under hypoxic conditions ."
],
"offsets": [
[
0,
134
]
]
}
] | [] | [] | [] | [] |
split_0_train_29898 | split_0_train_29898 | [
{
"id": "split_0_train_29898_passage",
"type": "progene_text",
"text": [
"It was the aim of the present study to investigate the effects of hypoxia on adhesion mechanisms in human VSMCs ."
],
"offsets": [
[
0,
113
]
]
}
] | [] | [] | [] | [] |
split_0_train_29899 | split_0_train_29899 | [
{
"id": "split_0_train_29899_passage",
"type": "progene_text",
"text": [
"Compared to normoxic cells , hypoxia ( 1 % O(2) , 24h ) significantly increased adhesion of VSMCs to collagen I by 30.2 % and fibronectin by 58.0 % ."
],
"offsets": [
[
0,
149
]
]
}
] | [
{
"id": "split_0_train_48207_entity",
"type": "progene_text",
"text": [
"collagen I"
],
"offsets": [
[
101,
111
]
],
"normalized": []
},
{
"id": "split_0_train_48208_entity",
"type": "progene_text",
"text": [
"fibronectin"
],
"offsets": [
[
126,
137
]
],
"normalized": []
}
] | [] | [] | [] |
Subsets and Splits