id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_4900
|
split_0_train_4900
|
[
{
"id": "split_0_train_4900_passage",
"type": "progene_text",
"text": [
"Expression of the respective polypeptides in Escherichia coli mutants lacking the DHQase or the SORase activity gave functional complementation only in case of the shorter polypeptide , indicating that skipping of a potential exon is a prerequisite for the production of an enzymatically active protein ."
],
"offsets": [
[
0,
304
]
]
}
] |
[
{
"id": "split_0_train_7873_entity",
"type": "progene_text",
"text": [
"DHQase"
],
"offsets": [
[
82,
88
]
],
"normalized": []
},
{
"id": "split_0_train_7874_entity",
"type": "progene_text",
"text": [
"SORase"
],
"offsets": [
[
96,
102
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4901
|
split_0_train_4901
|
[
{
"id": "split_0_train_4901_passage",
"type": "progene_text",
"text": [
"The deduced amino acid sequence revealed that the DHQase - SORase is most likely synthesized as a precursor with a very short ( 13-amino acid ) plastid - specific transit peptide ."
],
"offsets": [
[
0,
180
]
]
}
] |
[
{
"id": "split_0_train_7875_entity",
"type": "progene_text",
"text": [
"DHQase - SORase"
],
"offsets": [
[
50,
65
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4902
|
split_0_train_4902
|
[
{
"id": "split_0_train_4902_passage",
"type": "progene_text",
"text": [
"Like other genes encoding enzymes of the prechorismate pathway in tomato , this gene is elicitor - inducible ."
],
"offsets": [
[
0,
110
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4903
|
split_0_train_4903
|
[
{
"id": "split_0_train_4903_passage",
"type": "progene_text",
"text": [
"Tissue - specific expression resembles the patterns obtained for 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase 2 and dehydroquinate synthase genes ."
],
"offsets": [
[
0,
155
]
]
}
] |
[
{
"id": "split_0_train_7876_entity",
"type": "progene_text",
"text": [
"3-deoxy-D-arabino-heptulosonate 7-phosphate synthase 2"
],
"offsets": [
[
65,
119
]
],
"normalized": []
},
{
"id": "split_0_train_7877_entity",
"type": "progene_text",
"text": [
"dehydroquinate synthase"
],
"offsets": [
[
124,
147
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4904
|
split_0_train_4904
|
[
{
"id": "split_0_train_4904_passage",
"type": "progene_text",
"text": [
"This work completes our studies of the prechorismate pathway in that cDNAs for all seven enzymes ( including isozymes ) of the prechorismate pathway from tomato have now been characterized ."
],
"offsets": [
[
0,
190
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4905
|
split_0_train_4905
|
[
{
"id": "split_0_train_4905_passage",
"type": "progene_text",
"text": [
"Rickettsia felis : molecular characterization of a new member of the spotted fever group ."
],
"offsets": [
[
0,
90
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4906
|
split_0_train_4906
|
[
{
"id": "split_0_train_4906_passage",
"type": "progene_text",
"text": [
"In this report , placement of Rickettsia felis in the spotted fever group ( SFG ) rather than the typhus group ( TG ) of Rickettsia is proposed ."
],
"offsets": [
[
0,
145
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4907
|
split_0_train_4907
|
[
{
"id": "split_0_train_4907_passage",
"type": "progene_text",
"text": [
"The organism , which was first observed in cat fleas ( Ctenocephalides felis ) by electron microscopy , has not yet been reported to have been cultivated reproducibly , thereby limiting the standard rickettsial typing by serological means ."
],
"offsets": [
[
0,
240
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4908
|
split_0_train_4908
|
[
{
"id": "split_0_train_4908_passage",
"type": "progene_text",
"text": [
"To overcome this challenge , several genes were selected as targets to be utilized for the classification of R. felis ."
],
"offsets": [
[
0,
119
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4909
|
split_0_train_4909
|
[
{
"id": "split_0_train_4909_passage",
"type": "progene_text",
"text": [
"DNA from cat fleas naturally infected with R. felis was amplified by PCR utilizing primer sets specific for the 190 kDa surface antigen ( rOmpA ) and 17 kDa antigen genes ."
],
"offsets": [
[
0,
172
]
]
}
] |
[
{
"id": "split_0_train_7878_entity",
"type": "progene_text",
"text": [
"190 kDa surface antigen"
],
"offsets": [
[
112,
135
]
],
"normalized": []
},
{
"id": "split_0_train_7879_entity",
"type": "progene_text",
"text": [
"rOmpA"
],
"offsets": [
[
138,
143
]
],
"normalized": []
},
{
"id": "split_0_train_7880_entity",
"type": "progene_text",
"text": [
"17 kDa antigen"
],
"offsets": [
[
150,
164
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4910
|
split_0_train_4910
|
[
{
"id": "split_0_train_4910_passage",
"type": "progene_text",
"text": [
"The entire 5 , 513 bp rompA gene was sequenced , characterized and found to have several unique features when compared to the rompA genes of other Rickettsia ."
],
"offsets": [
[
0,
159
]
]
}
] |
[
{
"id": "split_0_train_7881_entity",
"type": "progene_text",
"text": [
"rompA"
],
"offsets": [
[
22,
27
]
],
"normalized": []
},
{
"id": "split_0_train_7882_entity",
"type": "progene_text",
"text": [
"rompA"
],
"offsets": [
[
126,
131
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4911
|
split_0_train_4911
|
[
{
"id": "split_0_train_4911_passage",
"type": "progene_text",
"text": [
"Phylogenetic analysis of the partial sequence of the 17 kDa antigen gene indicated that R. felis is less divergent from the SFG rickettsiae than from the TG rickettsiae ."
],
"offsets": [
[
0,
170
]
]
}
] |
[
{
"id": "split_0_train_7883_entity",
"type": "progene_text",
"text": [
"17 kDa antigen"
],
"offsets": [
[
53,
67
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4912
|
split_0_train_4912
|
[
{
"id": "split_0_train_4912_passage",
"type": "progene_text",
"text": [
"The data corroborate results from previous reports that analysed the citrate synthase , 16S rRNA , rompB ( 135 kDa surface antigen ) , metK , ftsY , polA and dnaE genes that placed R. felis as a member of the SFG ."
],
"offsets": [
[
0,
214
]
]
}
] |
[
{
"id": "split_0_train_7884_entity",
"type": "progene_text",
"text": [
"citrate synthase"
],
"offsets": [
[
69,
85
]
],
"normalized": []
},
{
"id": "split_0_train_7885_entity",
"type": "progene_text",
"text": [
"rompB"
],
"offsets": [
[
99,
104
]
],
"normalized": []
},
{
"id": "split_0_train_7886_entity",
"type": "progene_text",
"text": [
"metK"
],
"offsets": [
[
135,
139
]
],
"normalized": []
},
{
"id": "split_0_train_7887_entity",
"type": "progene_text",
"text": [
"ftsY"
],
"offsets": [
[
142,
146
]
],
"normalized": []
},
{
"id": "split_0_train_7888_entity",
"type": "progene_text",
"text": [
"polA"
],
"offsets": [
[
149,
153
]
],
"normalized": []
},
{
"id": "split_0_train_7889_entity",
"type": "progene_text",
"text": [
"dnaE"
],
"offsets": [
[
158,
162
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4913
|
split_0_train_4913
|
[
{
"id": "split_0_train_4913_passage",
"type": "progene_text",
"text": [
"The organism is passed trans - stadially and transovarially , and infection in the cat flea has been observed in the midgut , tracheal matrix , muscle , hypodermis , ovaries and testes ."
],
"offsets": [
[
0,
186
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4914
|
split_0_train_4914
|
[
{
"id": "split_0_train_4914_passage",
"type": "progene_text",
"text": [
"A novel nucleolar protein , NIFK , interacts with the forkhead associated domain of Ki-67 antigen in mitosis ."
],
"offsets": [
[
0,
110
]
]
}
] |
[
{
"id": "split_0_train_7890_entity",
"type": "progene_text",
"text": [
"NIFK"
],
"offsets": [
[
28,
32
]
],
"normalized": []
},
{
"id": "split_0_train_7891_entity",
"type": "progene_text",
"text": [
"Ki-67 antigen"
],
"offsets": [
[
84,
97
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4915
|
split_0_train_4915
|
[
{
"id": "split_0_train_4915_passage",
"type": "progene_text",
"text": [
"In a previous study , we demonstrated that the forkhead associated ( FHA ) domain of pKi-67 interacts with the novel kinesin - like protein , Hklp2 ( Sueishi , M. , Takagi , M. , and Yoneda , Y. ( 2000 ) J. Biol. Chem. 275 , 28888 - 28892 ) ."
],
"offsets": [
[
0,
242
]
]
}
] |
[
{
"id": "split_0_train_7892_entity",
"type": "progene_text",
"text": [
"pKi-67"
],
"offsets": [
[
85,
91
]
],
"normalized": []
},
{
"id": "split_0_train_7893_entity",
"type": "progene_text",
"text": [
"kinesin"
],
"offsets": [
[
117,
124
]
],
"normalized": []
},
{
"id": "split_0_train_7894_entity",
"type": "progene_text",
"text": [
"Hklp2"
],
"offsets": [
[
142,
147
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4916
|
split_0_train_4916
|
[
{
"id": "split_0_train_4916_passage",
"type": "progene_text",
"text": [
"In this study , we report on the identification of a putative RNA - binding protein of 293 residues as another binding partner of the FHA domain of pKi-67 ( referred to as NIFK for nucleolar protein interacting with the FHA domain of pKi-67 ) ."
],
"offsets": [
[
0,
244
]
]
}
] |
[
{
"id": "split_0_train_7895_entity",
"type": "progene_text",
"text": [
"pKi-67"
],
"offsets": [
[
148,
154
]
],
"normalized": []
},
{
"id": "split_0_train_7896_entity",
"type": "progene_text",
"text": [
"NIFK"
],
"offsets": [
[
172,
176
]
],
"normalized": []
},
{
"id": "split_0_train_7897_entity",
"type": "progene_text",
"text": [
"nucleolar protein interacting with the FHA domain of pKi-67"
],
"offsets": [
[
181,
240
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4917
|
split_0_train_4917
|
[
{
"id": "split_0_train_4917_passage",
"type": "progene_text",
"text": [
"Human NIFK ( hNIFK ) interacted with the FHA domain of pKi-67 ( Ki-FHA ) efficiently in vitro when hNIFK was derived from mitotically arrested cells ."
],
"offsets": [
[
0,
150
]
]
}
] |
[
{
"id": "split_0_train_7898_entity",
"type": "progene_text",
"text": [
"NIFK"
],
"offsets": [
[
6,
10
]
],
"normalized": []
},
{
"id": "split_0_train_7899_entity",
"type": "progene_text",
"text": [
"hNIFK"
],
"offsets": [
[
13,
18
]
],
"normalized": []
},
{
"id": "split_0_train_7900_entity",
"type": "progene_text",
"text": [
"pKi-67"
],
"offsets": [
[
55,
61
]
],
"normalized": []
},
{
"id": "split_0_train_7901_entity",
"type": "progene_text",
"text": [
"hNIFK"
],
"offsets": [
[
99,
104
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4918
|
split_0_train_4918
|
[
{
"id": "split_0_train_4918_passage",
"type": "progene_text",
"text": [
"In addition , a moiety of hNIFK was co - localized with pKi-67 at the peripheral region of mitotic chromosomes ."
],
"offsets": [
[
0,
112
]
]
}
] |
[
{
"id": "split_0_train_7902_entity",
"type": "progene_text",
"text": [
"hNIFK"
],
"offsets": [
[
26,
31
]
],
"normalized": []
},
{
"id": "split_0_train_7903_entity",
"type": "progene_text",
"text": [
"pKi-67"
],
"offsets": [
[
56,
62
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4919
|
split_0_train_4919
|
[
{
"id": "split_0_train_4919_passage",
"type": "progene_text",
"text": [
"The hNIFK domain that interacts with Ki-FHA was mapped in the yeast two - hybrid system to a portion encompassed by residues 226 - 269 ."
],
"offsets": [
[
0,
136
]
]
}
] |
[
{
"id": "split_0_train_7904_entity",
"type": "progene_text",
"text": [
"hNIFK"
],
"offsets": [
[
4,
9
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4920
|
split_0_train_4920
|
[
{
"id": "split_0_train_4920_passage",
"type": "progene_text",
"text": [
"In a binding assay utilizing Xenopus egg extracts , it was found that the mitosis - specific environment and two threonine residues within this portion of hNIFK ( Thr-234 and Thr-238 ) were crucial for the efficient interaction of hNIFK and Ki-FHA , suggesting that hNIFK interacts with Ki-FHA in a mitosis - specific and phosphorylation - dependent manner ."
],
"offsets": [
[
0,
358
]
]
}
] |
[
{
"id": "split_0_train_7905_entity",
"type": "progene_text",
"text": [
"hNIFK"
],
"offsets": [
[
155,
160
]
],
"normalized": []
},
{
"id": "split_0_train_7906_entity",
"type": "progene_text",
"text": [
"hNIFK"
],
"offsets": [
[
231,
236
]
],
"normalized": []
},
{
"id": "split_0_train_7907_entity",
"type": "progene_text",
"text": [
"hNIFK"
],
"offsets": [
[
266,
271
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4921
|
split_0_train_4921
|
[
{
"id": "split_0_train_4921_passage",
"type": "progene_text",
"text": [
"These findings provide a new clue to our understanding of the cellular function of pKi-67 ."
],
"offsets": [
[
0,
91
]
]
}
] |
[
{
"id": "split_0_train_7908_entity",
"type": "progene_text",
"text": [
"pKi-67"
],
"offsets": [
[
83,
89
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4922
|
split_0_train_4922
|
[
{
"id": "split_0_train_4922_passage",
"type": "progene_text",
"text": [
"BALB/c mice bearing a transgenic IL-12 receptor beta 2 gene exhibit a nonhealing phenotype to Leishmania major infection despite intact IL-12 signaling ."
],
"offsets": [
[
0,
153
]
]
}
] |
[
{
"id": "split_0_train_7909_entity",
"type": "progene_text",
"text": [
"IL-12 receptor beta 2"
],
"offsets": [
[
33,
54
]
],
"normalized": []
},
{
"id": "split_0_train_7910_entity",
"type": "progene_text",
"text": [
"IL-12"
],
"offsets": [
[
136,
141
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4923
|
split_0_train_4923
|
[
{
"id": "split_0_train_4923_passage",
"type": "progene_text",
"text": [
"In BALB/c mice infected with Leishmania major , early secretion of IL-4 leads to a Th2 - type response and nonhealing ."
],
"offsets": [
[
0,
119
]
]
}
] |
[
{
"id": "split_0_train_7911_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
67,
71
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4924
|
split_0_train_4924
|
[
{
"id": "split_0_train_4924_passage",
"type": "progene_text",
"text": [
"We explored the role of IL-4 - induced down - regulation of the IL-12Rbeta2 chain in the establishment of this Th2 response ."
],
"offsets": [
[
0,
125
]
]
}
] |
[
{
"id": "split_0_train_7912_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
24,
28
]
],
"normalized": []
},
{
"id": "split_0_train_7913_entity",
"type": "progene_text",
"text": [
"IL-12Rbeta2"
],
"offsets": [
[
64,
75
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4925
|
split_0_train_4925
|
[
{
"id": "split_0_train_4925_passage",
"type": "progene_text",
"text": [
"First , we showed that the draining lymph nodes of resistant C57BL / 6 mice infected with L. major were enriched in CD4 + / IL - 12Rbeta2 chain + cells producing IFN - gamma ."
],
"offsets": [
[
0,
175
]
]
}
] |
[
{
"id": "split_0_train_7914_entity",
"type": "progene_text",
"text": [
"CD4"
],
"offsets": [
[
116,
119
]
],
"normalized": []
},
{
"id": "split_0_train_7915_entity",
"type": "progene_text",
"text": [
"IL - 12Rbeta2"
],
"offsets": [
[
124,
137
]
],
"normalized": []
},
{
"id": "split_0_train_7916_entity",
"type": "progene_text",
"text": [
"IFN - gamma"
],
"offsets": [
[
162,
173
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4926
|
split_0_train_4926
|
[
{
"id": "split_0_train_4926_passage",
"type": "progene_text",
"text": [
"Next , we demonstrated that BALB / c background mice bearing an IL - 12Rbeta2 - chain transgene manifested a nonhealing phenotype similar to wild - type littermates despite the persistence of their ability to undergo STAT4 activation ."
],
"offsets": [
[
0,
235
]
]
}
] |
[
{
"id": "split_0_train_7917_entity",
"type": "progene_text",
"text": [
"IL - 12Rbeta2"
],
"offsets": [
[
64,
77
]
],
"normalized": []
},
{
"id": "split_0_train_7918_entity",
"type": "progene_text",
"text": [
"STAT4"
],
"offsets": [
[
217,
222
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4927
|
split_0_train_4927
|
[
{
"id": "split_0_train_4927_passage",
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"text": [
"Finally , we found that such transgenic mice display more severe infection than wild - type littermates when treated with IL-12 7 days after infection , and under this condition , the mice display increased Leishmania Ag - induced IL - 4 secretion ."
],
"offsets": [
[
0,
249
]
]
}
] |
[
{
"id": "split_0_train_7919_entity",
"type": "progene_text",
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"IL-12"
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122,
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{
"id": "split_0_train_7920_entity",
"type": "progene_text",
"text": [
"IL - 4"
],
"offsets": [
[
231,
237
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4928
|
split_0_train_4928
|
[
{
"id": "split_0_train_4928_passage",
"type": "progene_text",
"text": [
"These studies indicate that although CD4 + / IL-12Rbeta2 chain + T cells are important components of the Th1 response , maintenance of IL-12Rbeta2 chain expression is not sufficient to change a Th2 response to a Th1 response in vivo and thus to allow BALB / c mice to heal L. major infection ."
],
"offsets": [
[
0,
293
]
]
}
] |
[
{
"id": "split_0_train_7921_entity",
"type": "progene_text",
"text": [
"CD4"
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37,
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{
"id": "split_0_train_7922_entity",
"type": "progene_text",
"text": [
"IL-12Rbeta2"
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45,
56
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},
{
"id": "split_0_train_7923_entity",
"type": "progene_text",
"text": [
"IL-12Rbeta2"
],
"offsets": [
[
135,
146
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4929
|
split_0_train_4929
|
[
{
"id": "split_0_train_4929_passage",
"type": "progene_text",
"text": [
"Identification and characterization of a new mammalian glutaredoxin ( thioltransferase ) , Grx2 ."
],
"offsets": [
[
0,
97
]
]
}
] |
[
{
"id": "split_0_train_7924_entity",
"type": "progene_text",
"text": [
"glutaredoxin"
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[
55,
67
]
],
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},
{
"id": "split_0_train_7925_entity",
"type": "progene_text",
"text": [
"thioltransferase"
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[
70,
86
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},
{
"id": "split_0_train_7926_entity",
"type": "progene_text",
"text": [
"Grx2"
],
"offsets": [
[
91,
95
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4930
|
split_0_train_4930
|
[
{
"id": "split_0_train_4930_passage",
"type": "progene_text",
"text": [
"A thiol / disulfide oxidoreductase component of the GSH system , glutaredoxin ( Grx ) , is involved in the reduction of GSH - based mixed disulfides and participates in a variety of cellular redox pathways ."
],
"offsets": [
[
0,
207
]
]
}
] |
[
{
"id": "split_0_train_7927_entity",
"type": "progene_text",
"text": [
"thiol / disulfide oxidoreductase"
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[
2,
34
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{
"id": "split_0_train_7928_entity",
"type": "progene_text",
"text": [
"glutaredoxin"
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65,
77
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],
"normalized": []
},
{
"id": "split_0_train_7929_entity",
"type": "progene_text",
"text": [
"Grx"
],
"offsets": [
[
80,
83
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4931
|
split_0_train_4931
|
[
{
"id": "split_0_train_4931_passage",
"type": "progene_text",
"text": [
"A single cytosolic Grx ( Grx1 ) was previously described in mammals ."
],
"offsets": [
[
0,
69
]
]
}
] |
[
{
"id": "split_0_train_7930_entity",
"type": "progene_text",
"text": [
"Grx"
],
"offsets": [
[
19,
22
]
],
"normalized": []
},
{
"id": "split_0_train_7931_entity",
"type": "progene_text",
"text": [
"Grx1"
],
"offsets": [
[
25,
29
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4932
|
split_0_train_4932
|
[
{
"id": "split_0_train_4932_passage",
"type": "progene_text",
"text": [
"We now report identification and characterization of a second mammalian Grx , designated Grx2 ."
],
"offsets": [
[
0,
95
]
]
}
] |
[
{
"id": "split_0_train_7932_entity",
"type": "progene_text",
"text": [
"Grx"
],
"offsets": [
[
72,
75
]
],
"normalized": []
},
{
"id": "split_0_train_7933_entity",
"type": "progene_text",
"text": [
"Grx2"
],
"offsets": [
[
89,
93
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4933
|
split_0_train_4933
|
[
{
"id": "split_0_train_4933_passage",
"type": "progene_text",
"text": [
"Grx2 exhibited 36 % identity with Grx1 and had a disulfide active center containing the Cys-Ser-Tyr-Cys motif ."
],
"offsets": [
[
0,
111
]
]
}
] |
[
{
"id": "split_0_train_7934_entity",
"type": "progene_text",
"text": [
"Grx2"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_7935_entity",
"type": "progene_text",
"text": [
"Grx1"
],
"offsets": [
[
34,
38
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4934
|
split_0_train_4934
|
[
{
"id": "split_0_train_4934_passage",
"type": "progene_text",
"text": [
"Grx2 was encoded in the genomes of mammals and birds and expressed in a variety of cell types ."
],
"offsets": [
[
0,
95
]
]
}
] |
[
{
"id": "split_0_train_7936_entity",
"type": "progene_text",
"text": [
"Grx2"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4935
|
split_0_train_4935
|
[
{
"id": "split_0_train_4935_passage",
"type": "progene_text",
"text": [
"The gene for human Grx2 consisted of four exons and three introns , spanned 10 kilobase pairs , and localized to chromosome 1q31.2 - 31.3 ."
],
"offsets": [
[
0,
139
]
]
}
] |
[
{
"id": "split_0_train_7937_entity",
"type": "progene_text",
"text": [
"Grx2"
],
"offsets": [
[
19,
23
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4936
|
split_0_train_4936
|
[
{
"id": "split_0_train_4936_passage",
"type": "progene_text",
"text": [
"The coding sequence was present in all exons , with the first exon encoding a mitochondrial signal peptide ."
],
"offsets": [
[
0,
108
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4937
|
split_0_train_4937
|
[
{
"id": "split_0_train_4937_passage",
"type": "progene_text",
"text": [
"The mitochondrial leader sequence was also present in mouse and rat Grx2 sequences and was shown to direct either Grx2 or green fluorescent protein to mitochondria ."
],
"offsets": [
[
0,
165
]
]
}
] |
[
{
"id": "split_0_train_7938_entity",
"type": "progene_text",
"text": [
"Grx2"
],
"offsets": [
[
68,
72
]
],
"normalized": []
},
{
"id": "split_0_train_7939_entity",
"type": "progene_text",
"text": [
"Grx2"
],
"offsets": [
[
114,
118
]
],
"normalized": []
},
{
"id": "split_0_train_7940_entity",
"type": "progene_text",
"text": [
"green fluorescent protein"
],
"offsets": [
[
122,
147
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4938
|
split_0_train_4938
|
[
{
"id": "split_0_train_4938_passage",
"type": "progene_text",
"text": [
"Alternative splicing forms of mammalian Grx2 mRNAs were identified that differed in sequences upstream of exon 2 ."
],
"offsets": [
[
0,
114
]
]
}
] |
[
{
"id": "split_0_train_7941_entity",
"type": "progene_text",
"text": [
"Grx2"
],
"offsets": [
[
40,
44
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4939
|
split_0_train_4939
|
[
{
"id": "split_0_train_4939_passage",
"type": "progene_text",
"text": [
"To functionally characterize the new protein , human and mouse Grx2 proteins were expressed in Escherichia coli , and the purified proteins were shown to reduce mixed disulfides formed between GSH and S-sulfocysteine , hydroxyethyldisulfide , or cystine ."
],
"offsets": [
[
0,
255
]
]
}
] |
[
{
"id": "split_0_train_7942_entity",
"type": "progene_text",
"text": [
"Grx2"
],
"offsets": [
[
63,
67
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4940
|
split_0_train_4940
|
[
{
"id": "split_0_train_4940_passage",
"type": "progene_text",
"text": [
"Grx1 and Grx2 were sensitive to inactivation by iodoacetamide and H(2)O(2) and exhibited similar pH dependence of catalytic activity ."
],
"offsets": [
[
0,
134
]
]
}
] |
[
{
"id": "split_0_train_7943_entity",
"type": "progene_text",
"text": [
"Grx1"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_7944_entity",
"type": "progene_text",
"text": [
"Grx2"
],
"offsets": [
[
9,
13
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4941
|
split_0_train_4941
|
[
{
"id": "split_0_train_4941_passage",
"type": "progene_text",
"text": [
"However , H(2)O(2)-inactivated Grx2 could only be reactivated with 5 mm GSH , whereas Grx1 could also be reactivated with dithiothreitol or thioredoxin / thioredoxin reductase ."
],
"offsets": [
[
0,
177
]
]
}
] |
[
{
"id": "split_0_train_7945_entity",
"type": "progene_text",
"text": [
"Grx2"
],
"offsets": [
[
31,
35
]
],
"normalized": []
},
{
"id": "split_0_train_7946_entity",
"type": "progene_text",
"text": [
"Grx1"
],
"offsets": [
[
86,
90
]
],
"normalized": []
},
{
"id": "split_0_train_7947_entity",
"type": "progene_text",
"text": [
"thioredoxin / thioredoxin reductase"
],
"offsets": [
[
140,
175
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4942
|
split_0_train_4942
|
[
{
"id": "split_0_train_4942_passage",
"type": "progene_text",
"text": [
"The Grx2 structural model suggested a common reaction mechanism for this class of proteins ."
],
"offsets": [
[
0,
92
]
]
}
] |
[
{
"id": "split_0_train_7948_entity",
"type": "progene_text",
"text": [
"Grx2"
],
"offsets": [
[
4,
8
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4943
|
split_0_train_4943
|
[
{
"id": "split_0_train_4943_passage",
"type": "progene_text",
"text": [
"The data provide the first example of a mitochondrial Grx and also indicate the occurrence of a second functional Grx in mammals ."
],
"offsets": [
[
0,
130
]
]
}
] |
[
{
"id": "split_0_train_7949_entity",
"type": "progene_text",
"text": [
"Grx"
],
"offsets": [
[
54,
57
]
],
"normalized": []
},
{
"id": "split_0_train_7950_entity",
"type": "progene_text",
"text": [
"Grx"
],
"offsets": [
[
114,
117
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4944
|
split_0_train_4944
|
[
{
"id": "split_0_train_4944_passage",
"type": "progene_text",
"text": [
"Maternal undernutrition during early to midgestation programs tissue - specific alterations in the expression of the glucocorticoid receptor , 11beta-hydroxysteroid dehydrogenase isoforms , and type 1 angiotensin ii receptor in neonatal sheep ."
],
"offsets": [
[
0,
244
]
]
}
] |
[
{
"id": "split_0_train_7951_entity",
"type": "progene_text",
"text": [
"glucocorticoid receptor"
],
"offsets": [
[
117,
140
]
],
"normalized": []
},
{
"id": "split_0_train_7952_entity",
"type": "progene_text",
"text": [
"11beta-hydroxysteroid dehydrogenase"
],
"offsets": [
[
143,
178
]
],
"normalized": []
},
{
"id": "split_0_train_7953_entity",
"type": "progene_text",
"text": [
"type 1 angiotensin ii receptor"
],
"offsets": [
[
194,
224
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4945
|
split_0_train_4945
|
[
{
"id": "split_0_train_4945_passage",
"type": "progene_text",
"text": [
"We have investigated the effects of maternal nutrient restriction in the sheep during the period of rapid placental growth ( i.e. 28 - 77 days gestation ; term = 147 days ) on feto - placental growth and expression of the glucocorticoid receptor ( GR ) , types 1 and 2 11beta - hydroxysteroid dehydrogenase ( 11betaHSD1 , 11betaHSD2 ) , and types 1 and 2 angiotensin II receptor ( AT1 , AT2 ) in fetal and neonatal offspring ."
],
"offsets": [
[
0,
426
]
]
}
] |
[
{
"id": "split_0_train_7954_entity",
"type": "progene_text",
"text": [
"glucocorticoid receptor"
],
"offsets": [
[
222,
245
]
],
"normalized": []
},
{
"id": "split_0_train_7955_entity",
"type": "progene_text",
"text": [
"GR"
],
"offsets": [
[
248,
250
]
],
"normalized": []
},
{
"id": "split_0_train_7956_entity",
"type": "progene_text",
"text": [
"types 1 and 2 11beta - hydroxysteroid dehydrogenase"
],
"offsets": [
[
255,
306
]
],
"normalized": []
},
{
"id": "split_0_train_7957_entity",
"type": "progene_text",
"text": [
"11betaHSD1"
],
"offsets": [
[
309,
319
]
],
"normalized": []
},
{
"id": "split_0_train_7958_entity",
"type": "progene_text",
"text": [
"11betaHSD2"
],
"offsets": [
[
322,
332
]
],
"normalized": []
},
{
"id": "split_0_train_7959_entity",
"type": "progene_text",
"text": [
"types 1 and 2 angiotensin II receptor"
],
"offsets": [
[
341,
378
]
],
"normalized": []
},
{
"id": "split_0_train_7960_entity",
"type": "progene_text",
"text": [
"AT1"
],
"offsets": [
[
381,
384
]
],
"normalized": []
},
{
"id": "split_0_train_7961_entity",
"type": "progene_text",
"text": [
"AT2"
],
"offsets": [
[
387,
390
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4946
|
split_0_train_4946
|
[
{
"id": "split_0_train_4946_passage",
"type": "progene_text",
"text": [
"Ewes ( n = 63 ) of similar age , body weight , and body composition were randomly allocated to a nutrient - restricted ( NR ) group in which they consumed 3.2 MJ / day metabolizable energy ( ME ; equivalent to 50 % of predicted requirements ) or to a control group in which they consumed 6.7 MJ / day ME ( equivalent to 110 % of predicted requirements ) ."
],
"offsets": [
[
0,
355
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4947
|
split_0_train_4947
|
[
{
"id": "split_0_train_4947_passage",
"type": "progene_text",
"text": [
"After 77 days gestation , ewes from both dietary groups consumed close to 100 % of ME requirements up to term ."
],
"offsets": [
[
0,
111
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4948
|
split_0_train_4948
|
[
{
"id": "split_0_train_4948_passage",
"type": "progene_text",
"text": [
"Newborn offspring of NR ewes were of similar body weight , but had increased crown - rump length , greater placental weight , and increased placental / body weight ratio ( P < 0.01 ) compared with controls ."
],
"offsets": [
[
0,
207
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4949
|
split_0_train_4949
|
[
{
"id": "split_0_train_4949_passage",
"type": "progene_text",
"text": [
"Their kidneys were heavier ( P < 0.05 ) , but shorter in length , with increased ratios of transverse width to length ( P < 0.001 ) ."
],
"offsets": [
[
0,
133
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4950
|
split_0_train_4950
|
[
{
"id": "split_0_train_4950_passage",
"type": "progene_text",
"text": [
"GR messenger RNA ( mRNA ) expression in neonatal offspring from NR ewes was increased in adrenal , kidney , liver , lung , and perirenal adipose tissue ( P < 0.01 ) ."
],
"offsets": [
[
0,
166
]
]
}
] |
[
{
"id": "split_0_train_7962_entity",
"type": "progene_text",
"text": [
"GR"
],
"offsets": [
[
0,
2
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4951
|
split_0_train_4951
|
[
{
"id": "split_0_train_4951_passage",
"type": "progene_text",
"text": [
"Conversely , 11betaHSD1 mRNA expression was unaffected , except in perirenal adipose tissue , where it was higher in lambs born to NR ewes ( P < 0.01 ) ."
],
"offsets": [
[
0,
153
]
]
}
] |
[
{
"id": "split_0_train_7963_entity",
"type": "progene_text",
"text": [
"11betaHSD1"
],
"offsets": [
[
13,
23
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4952
|
split_0_train_4952
|
[
{
"id": "split_0_train_4952_passage",
"type": "progene_text",
"text": [
"11betaHSD2 mRNA expression was decreased in adrenals and kidney ( P < 0.001 ) ."
],
"offsets": [
[
0,
79
]
]
}
] |
[
{
"id": "split_0_train_7964_entity",
"type": "progene_text",
"text": [
"11betaHSD2"
],
"offsets": [
[
0,
10
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4953
|
split_0_train_4953
|
[
{
"id": "split_0_train_4953_passage",
"type": "progene_text",
"text": [
"Maternal NR also resulted in significantly increased AT1 expression in those tissues in which expression of GR was increased and/or 11betaHSD2 was decreased , i.e. adrenals , kidney , liver , and lung ."
],
"offsets": [
[
0,
202
]
]
}
] |
[
{
"id": "split_0_train_7965_entity",
"type": "progene_text",
"text": [
"AT1"
],
"offsets": [
[
53,
56
]
],
"normalized": []
},
{
"id": "split_0_train_7966_entity",
"type": "progene_text",
"text": [
"GR"
],
"offsets": [
[
108,
110
]
],
"normalized": []
},
{
"id": "split_0_train_7967_entity",
"type": "progene_text",
"text": [
"11betaHSD2"
],
"offsets": [
[
132,
142
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4954
|
split_0_train_4954
|
[
{
"id": "split_0_train_4954_passage",
"type": "progene_text",
"text": [
"AT2 expression was unaffected by maternal NR ."
],
"offsets": [
[
0,
46
]
]
}
] |
[
{
"id": "split_0_train_7968_entity",
"type": "progene_text",
"text": [
"AT2"
],
"offsets": [
[
0,
3
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4955
|
split_0_train_4955
|
[
{
"id": "split_0_train_4955_passage",
"type": "progene_text",
"text": [
"Although 11betaHSD2 mRNA was undetectable in term placenta , it was abundant in midgestation placenta and was lower after maternal NR ( P < 0.001 ) ."
],
"offsets": [
[
0,
149
]
]
}
] |
[
{
"id": "split_0_train_7969_entity",
"type": "progene_text",
"text": [
"11betaHSD2"
],
"offsets": [
[
9,
19
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4956
|
split_0_train_4956
|
[
{
"id": "split_0_train_4956_passage",
"type": "progene_text",
"text": [
"There was close agreement between levels of 11betaHSD enzyme ( i.e. 11beta-dehydrogenase and 11-oxoreductase ) activities and abundance of 11betaHSD1 mRNA and 11betaHSD2 mRNA expression ."
],
"offsets": [
[
0,
187
]
]
}
] |
[
{
"id": "split_0_train_7970_entity",
"type": "progene_text",
"text": [
"11betaHSD"
],
"offsets": [
[
44,
53
]
],
"normalized": []
},
{
"id": "split_0_train_7971_entity",
"type": "progene_text",
"text": [
"11beta-dehydrogenase"
],
"offsets": [
[
68,
88
]
],
"normalized": []
},
{
"id": "split_0_train_7972_entity",
"type": "progene_text",
"text": [
"11-oxoreductase"
],
"offsets": [
[
93,
108
]
],
"normalized": []
},
{
"id": "split_0_train_7973_entity",
"type": "progene_text",
"text": [
"11betaHSD1"
],
"offsets": [
[
139,
149
]
],
"normalized": []
},
{
"id": "split_0_train_7974_entity",
"type": "progene_text",
"text": [
"11betaHSD2"
],
"offsets": [
[
159,
169
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4957
|
split_0_train_4957
|
[
{
"id": "split_0_train_4957_passage",
"type": "progene_text",
"text": [
"The persistence of tissue - specific increases in the expression of GR , 11betaHSD1 and AT1 and decreases in the expression of 11betaHSD2 in adrenals and kidney in newborn offspring in response to a defined period of maternal nutrient restriction during early to midgestation suggests that gene expression has been programmed by nutrient availability to the fetus before birth ."
],
"offsets": [
[
0,
378
]
]
}
] |
[
{
"id": "split_0_train_7975_entity",
"type": "progene_text",
"text": [
"GR"
],
"offsets": [
[
68,
70
]
],
"normalized": []
},
{
"id": "split_0_train_7976_entity",
"type": "progene_text",
"text": [
"11betaHSD1"
],
"offsets": [
[
73,
83
]
],
"normalized": []
},
{
"id": "split_0_train_7977_entity",
"type": "progene_text",
"text": [
"AT1"
],
"offsets": [
[
88,
91
]
],
"normalized": []
},
{
"id": "split_0_train_7978_entity",
"type": "progene_text",
"text": [
"11betaHSD2"
],
"offsets": [
[
127,
137
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4958
|
split_0_train_4958
|
[
{
"id": "split_0_train_4958_passage",
"type": "progene_text",
"text": [
"These data suggest key potential mechanisms by which maternal nutrition prenatally programs physiological pathways , such as the renin - angiotensin system , in the offspring that may lead to raised blood pressure and other cardiovascular disease risk factors in later life ."
],
"offsets": [
[
0,
275
]
]
}
] |
[
{
"id": "split_0_train_7979_entity",
"type": "progene_text",
"text": [
"renin"
],
"offsets": [
[
129,
134
]
],
"normalized": []
},
{
"id": "split_0_train_7980_entity",
"type": "progene_text",
"text": [
"angiotensin"
],
"offsets": [
[
137,
148
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4959
|
split_0_train_4959
|
[
{
"id": "split_0_train_4959_passage",
"type": "progene_text",
"text": [
"Identification of a cis - regulatory element for L1 layer - specific gene expression , which is targeted by an L1 - specific homeodomain protein ."
],
"offsets": [
[
0,
146
]
]
}
] |
[
{
"id": "split_0_train_7981_entity",
"type": "progene_text",
"text": [
"homeodomain protein"
],
"offsets": [
[
125,
144
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4960
|
split_0_train_4960
|
[
{
"id": "split_0_train_4960_passage",
"type": "progene_text",
"text": [
"The Arabidopsis thaliana PROTODERMAL FACTOR1 ( PDF1 ) gene encoding a putative extracellular proline - rich protein is exclusively expressed in the L1 layer of shoot apices and the protoderm of organ primordia ."
],
"offsets": [
[
0,
211
]
]
}
] |
[
{
"id": "split_0_train_7982_entity",
"type": "progene_text",
"text": [
"PROTODERMAL FACTOR1"
],
"offsets": [
[
25,
44
]
],
"normalized": []
},
{
"id": "split_0_train_7983_entity",
"type": "progene_text",
"text": [
"PDF1"
],
"offsets": [
[
47,
51
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4961
|
split_0_train_4961
|
[
{
"id": "split_0_train_4961_passage",
"type": "progene_text",
"text": [
"In order to identify essential cis - regulatory sequences required for the L1 layer - specific expression , a series of 5 ' deletions of the PDF1 promoter were fused to the beta - glucronidase ( GUS ) gene and introduced into Arabidopsis plants ."
],
"offsets": [
[
0,
246
]
]
}
] |
[
{
"id": "split_0_train_7984_entity",
"type": "progene_text",
"text": [
"PDF1"
],
"offsets": [
[
141,
145
]
],
"normalized": []
},
{
"id": "split_0_train_7985_entity",
"type": "progene_text",
"text": [
"beta - glucronidase"
],
"offsets": [
[
173,
192
]
],
"normalized": []
},
{
"id": "split_0_train_7986_entity",
"type": "progene_text",
"text": [
"GUS"
],
"offsets": [
[
195,
198
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4962
|
split_0_train_4962
|
[
{
"id": "split_0_train_4962_passage",
"type": "progene_text",
"text": [
"Our analysis revealed that the minimum region necessary to confer L1 - specific expression of PDF1 is confined within a 260 - bp fragment upstream of the transcription start site ."
],
"offsets": [
[
0,
180
]
]
}
] |
[
{
"id": "split_0_train_7987_entity",
"type": "progene_text",
"text": [
"PDF1"
],
"offsets": [
[
94,
98
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4963
|
split_0_train_4963
|
[
{
"id": "split_0_train_4963_passage",
"type": "progene_text",
"text": [
"We identified an 8 - bp motif in this region that is conserved between promoter regions of all the L1 - specific genes so far cloned , and we designated it the L1 box ."
],
"offsets": [
[
0,
168
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4964
|
split_0_train_4964
|
[
{
"id": "split_0_train_4964_passage",
"type": "progene_text",
"text": [
"Electrophoretic mobility shift assays demonstrated that the L1 - specific homeodomain protein ATML1 can bind to the L1 box sequence in vitro ."
],
"offsets": [
[
0,
142
]
]
}
] |
[
{
"id": "split_0_train_7988_entity",
"type": "progene_text",
"text": [
"homeodomain protein"
],
"offsets": [
[
74,
93
]
],
"normalized": []
},
{
"id": "split_0_train_7989_entity",
"type": "progene_text",
"text": [
"ATML1"
],
"offsets": [
[
94,
99
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4965
|
split_0_train_4965
|
[
{
"id": "split_0_train_4965_passage",
"type": "progene_text",
"text": [
"The GUS expression in transgenic plants disappeared when a mutation that abolishes binding of ATML1 was introduced into the PDF1 l1 box sequence of the construct ."
],
"offsets": [
[
0,
163
]
]
}
] |
[
{
"id": "split_0_train_7990_entity",
"type": "progene_text",
"text": [
"GUS"
],
"offsets": [
[
4,
7
]
],
"normalized": []
},
{
"id": "split_0_train_7991_entity",
"type": "progene_text",
"text": [
"ATML1"
],
"offsets": [
[
94,
99
]
],
"normalized": []
},
{
"id": "split_0_train_7992_entity",
"type": "progene_text",
"text": [
"PDF1"
],
"offsets": [
[
124,
128
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4966
|
split_0_train_4966
|
[
{
"id": "split_0_train_4966_passage",
"type": "progene_text",
"text": [
"These results suggest that the L1 box plays a crucial role in the regulation of PDF1 expression in L1 cells and that ATML1 could cooperate to drive L1 - specific expression ."
],
"offsets": [
[
0,
174
]
]
}
] |
[
{
"id": "split_0_train_7993_entity",
"type": "progene_text",
"text": [
"PDF1"
],
"offsets": [
[
80,
84
]
],
"normalized": []
},
{
"id": "split_0_train_7994_entity",
"type": "progene_text",
"text": [
"ATML1"
],
"offsets": [
[
117,
122
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4967
|
split_0_train_4967
|
[
{
"id": "split_0_train_4967_passage",
"type": "progene_text",
"text": [
"Involvement of TRAIL / TRAIL-R interaction in IFN-alpha - induced apoptosis of Daudi B lymphoma cells ."
],
"offsets": [
[
0,
103
]
]
}
] |
[
{
"id": "split_0_train_7995_entity",
"type": "progene_text",
"text": [
"TRAIL"
],
"offsets": [
[
15,
20
]
],
"normalized": []
},
{
"id": "split_0_train_7996_entity",
"type": "progene_text",
"text": [
"TRAIL-R"
],
"offsets": [
[
23,
30
]
],
"normalized": []
},
{
"id": "split_0_train_7997_entity",
"type": "progene_text",
"text": [
"IFN-alpha"
],
"offsets": [
[
46,
55
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4968
|
split_0_train_4968
|
[
{
"id": "split_0_train_4968_passage",
"type": "progene_text",
"text": [
"Interferon-alpha ( IFN-alpha ) exerts the anti - tumour effect on various tumours at least partly through induction of apoptosis ."
],
"offsets": [
[
0,
130
]
]
}
] |
[
{
"id": "split_0_train_7998_entity",
"type": "progene_text",
"text": [
"Interferon-alpha"
],
"offsets": [
[
0,
16
]
],
"normalized": []
},
{
"id": "split_0_train_7999_entity",
"type": "progene_text",
"text": [
"IFN-alpha"
],
"offsets": [
[
19,
28
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4969
|
split_0_train_4969
|
[
{
"id": "split_0_train_4969_passage",
"type": "progene_text",
"text": [
"Apoptosis is induced by members of the tumour necrosis factor ( TNF ) family , including Fas ( CD95 ) and TNF - related apoptosis - inducing ligand ( TRAIL ) ."
],
"offsets": [
[
0,
159
]
]
}
] |
[
{
"id": "split_0_train_8000_entity",
"type": "progene_text",
"text": [
"tumour necrosis factor ( TNF ) family"
],
"offsets": [
[
39,
76
]
],
"normalized": []
},
{
"id": "split_0_train_8001_entity",
"type": "progene_text",
"text": [
"Fas"
],
"offsets": [
[
89,
92
]
],
"normalized": []
},
{
"id": "split_0_train_8002_entity",
"type": "progene_text",
"text": [
"CD95"
],
"offsets": [
[
95,
99
]
],
"normalized": []
},
{
"id": "split_0_train_8003_entity",
"type": "progene_text",
"text": [
"TNF - related apoptosis - inducing ligand"
],
"offsets": [
[
106,
147
]
],
"normalized": []
},
{
"id": "split_0_train_8004_entity",
"type": "progene_text",
"text": [
"TRAIL"
],
"offsets": [
[
150,
155
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4970
|
split_0_train_4970
|
[
{
"id": "split_0_train_4970_passage",
"type": "progene_text",
"text": [
"In the present study , we examined whether the TRAIL / TRAIL-R system is involved in IFN-alpha - induced apoptosis using Daudi B lymphoma cells ."
],
"offsets": [
[
0,
145
]
]
}
] |
[
{
"id": "split_0_train_8005_entity",
"type": "progene_text",
"text": [
"TRAIL"
],
"offsets": [
[
47,
52
]
],
"normalized": []
},
{
"id": "split_0_train_8006_entity",
"type": "progene_text",
"text": [
"TRAIL-R"
],
"offsets": [
[
55,
62
]
],
"normalized": []
},
{
"id": "split_0_train_8007_entity",
"type": "progene_text",
"text": [
"IFN-alpha"
],
"offsets": [
[
85,
94
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4971
|
split_0_train_4971
|
[
{
"id": "split_0_train_4971_passage",
"type": "progene_text",
"text": [
"IFN-alpha upregulated the expression of TRAIL within 12 h , as assessed by flow cytometry and RT - PCR , and the level increased with time until 72 h ."
],
"offsets": [
[
0,
151
]
]
}
] |
[
{
"id": "split_0_train_8008_entity",
"type": "progene_text",
"text": [
"IFN-alpha"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "split_0_train_8009_entity",
"type": "progene_text",
"text": [
"TRAIL"
],
"offsets": [
[
40,
45
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4972
|
split_0_train_4972
|
[
{
"id": "split_0_train_4972_passage",
"type": "progene_text",
"text": [
"The levels of both TRAIL-R1 and TRAIL-R2 , low in Daudi cells , were enhanced by IFN-alpha ."
],
"offsets": [
[
0,
92
]
]
}
] |
[
{
"id": "split_0_train_8010_entity",
"type": "progene_text",
"text": [
"TRAIL-R1"
],
"offsets": [
[
19,
27
]
],
"normalized": []
},
{
"id": "split_0_train_8011_entity",
"type": "progene_text",
"text": [
"TRAIL-R2"
],
"offsets": [
[
32,
40
]
],
"normalized": []
},
{
"id": "split_0_train_8012_entity",
"type": "progene_text",
"text": [
"IFN-alpha"
],
"offsets": [
[
81,
90
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4973
|
split_0_train_4973
|
[
{
"id": "split_0_train_4973_passage",
"type": "progene_text",
"text": [
"The enhanced TRAIL - R1 / - R2 appeared to function as a death - inducing molecule since IFN-alpha - stimulated cells were more susceptible to TRAIL - induced cell death ."
],
"offsets": [
[
0,
171
]
]
}
] |
[
{
"id": "split_0_train_8013_entity",
"type": "progene_text",
"text": [
"TRAIL - R1 / - R2"
],
"offsets": [
[
13,
30
]
],
"normalized": []
},
{
"id": "split_0_train_8014_entity",
"type": "progene_text",
"text": [
"IFN-alpha"
],
"offsets": [
[
89,
98
]
],
"normalized": []
},
{
"id": "split_0_train_8015_entity",
"type": "progene_text",
"text": [
"TRAIL"
],
"offsets": [
[
143,
148
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4974
|
split_0_train_4974
|
[
{
"id": "split_0_train_4974_passage",
"type": "progene_text",
"text": [
"The IFN-alpha - stimulated Daudi cells or their derived culture supernatants displayed cytotoxicity against TRAIL - sensitive , but not resistant lines ."
],
"offsets": [
[
0,
153
]
]
}
] |
[
{
"id": "split_0_train_8016_entity",
"type": "progene_text",
"text": [
"IFN-alpha"
],
"offsets": [
[
4,
13
]
],
"normalized": []
},
{
"id": "split_0_train_8017_entity",
"type": "progene_text",
"text": [
"TRAIL"
],
"offsets": [
[
108,
113
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4975
|
split_0_train_4975
|
[
{
"id": "split_0_train_4975_passage",
"type": "progene_text",
"text": [
"Moreover , the IFN-alpha - induced reduction in mitochondrial membrane potential preceding the induction of apoptosis was substantially prevented by neutralizing anti - TRAIL monoclonal antibody ."
],
"offsets": [
[
0,
196
]
]
}
] |
[
{
"id": "split_0_train_8018_entity",
"type": "progene_text",
"text": [
"IFN-alpha"
],
"offsets": [
[
15,
24
]
],
"normalized": []
},
{
"id": "split_0_train_8019_entity",
"type": "progene_text",
"text": [
"TRAIL"
],
"offsets": [
[
169,
174
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4976
|
split_0_train_4976
|
[
{
"id": "split_0_train_4976_passage",
"type": "progene_text",
"text": [
"Taken together , IFN-alpha - induced apoptosis appears to be mediated by the autocrine and/or paracrine loop involving TRAIL / TRAIL-R ."
],
"offsets": [
[
0,
136
]
]
}
] |
[
{
"id": "split_0_train_8020_entity",
"type": "progene_text",
"text": [
"IFN-alpha"
],
"offsets": [
[
17,
26
]
],
"normalized": []
},
{
"id": "split_0_train_8021_entity",
"type": "progene_text",
"text": [
"TRAIL"
],
"offsets": [
[
119,
124
]
],
"normalized": []
},
{
"id": "split_0_train_8022_entity",
"type": "progene_text",
"text": [
"TRAIL-R"
],
"offsets": [
[
127,
134
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4977
|
split_0_train_4977
|
[
{
"id": "split_0_train_4977_passage",
"type": "progene_text",
"text": [
"Human CC chemokine liver - expressed chemokine / CCL16 is a functional ligand for CCR1 , CCR2 and CCR5 , and constitutively expressed by hepatocytes ."
],
"offsets": [
[
0,
150
]
]
}
] |
[
{
"id": "split_0_train_8023_entity",
"type": "progene_text",
"text": [
"CC chemokine"
],
"offsets": [
[
6,
18
]
],
"normalized": []
},
{
"id": "split_0_train_8024_entity",
"type": "progene_text",
"text": [
"liver - expressed chemokine"
],
"offsets": [
[
19,
46
]
],
"normalized": []
},
{
"id": "split_0_train_8025_entity",
"type": "progene_text",
"text": [
"CCL16"
],
"offsets": [
[
49,
54
]
],
"normalized": []
},
{
"id": "split_0_train_8026_entity",
"type": "progene_text",
"text": [
"CCR1"
],
"offsets": [
[
82,
86
]
],
"normalized": []
},
{
"id": "split_0_train_8027_entity",
"type": "progene_text",
"text": [
"CCR2"
],
"offsets": [
[
89,
93
]
],
"normalized": []
},
{
"id": "split_0_train_8028_entity",
"type": "progene_text",
"text": [
"CCR5"
],
"offsets": [
[
98,
102
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4978
|
split_0_train_4978
|
[
{
"id": "split_0_train_4978_passage",
"type": "progene_text",
"text": [
"Liver - expressed chemokine ( LEC ) / CCL16 is a human CC chemokine selectively expressed in the liver ."
],
"offsets": [
[
0,
104
]
]
}
] |
[
{
"id": "split_0_train_8029_entity",
"type": "progene_text",
"text": [
"Liver - expressed chemokine"
],
"offsets": [
[
0,
27
]
],
"normalized": []
},
{
"id": "split_0_train_8030_entity",
"type": "progene_text",
"text": [
"LEC"
],
"offsets": [
[
30,
33
]
],
"normalized": []
},
{
"id": "split_0_train_8031_entity",
"type": "progene_text",
"text": [
"CCL16"
],
"offsets": [
[
38,
43
]
],
"normalized": []
},
{
"id": "split_0_train_8032_entity",
"type": "progene_text",
"text": [
"CC chemokine"
],
"offsets": [
[
55,
67
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4979
|
split_0_train_4979
|
[
{
"id": "split_0_train_4979_passage",
"type": "progene_text",
"text": [
"Here , we investigated its receptor usage by calcium mobilization and chemotactic assays using mouse L1.2 pre-B cell lines stably expressing a panel of 12 human chemokine receptors ."
],
"offsets": [
[
0,
182
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4980
|
split_0_train_4980
|
[
{
"id": "split_0_train_4980_passage",
"type": "progene_text",
"text": [
"At relatively high concentrations , LEC induced calcium mobilization and chemotaxis via CCR1 and CCR2 ."
],
"offsets": [
[
0,
103
]
]
}
] |
[
{
"id": "split_0_train_8033_entity",
"type": "progene_text",
"text": [
"LEC"
],
"offsets": [
[
36,
39
]
],
"normalized": []
},
{
"id": "split_0_train_8034_entity",
"type": "progene_text",
"text": [
"CCR1"
],
"offsets": [
[
88,
92
]
],
"normalized": []
},
{
"id": "split_0_train_8035_entity",
"type": "progene_text",
"text": [
"CCR2"
],
"offsets": [
[
97,
101
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4981
|
split_0_train_4981
|
[
{
"id": "split_0_train_4981_passage",
"type": "progene_text",
"text": [
"LEC also induced calcium mobilization , but marginal chemotaxis via CCR5 ."
],
"offsets": [
[
0,
74
]
]
}
] |
[
{
"id": "split_0_train_8036_entity",
"type": "progene_text",
"text": [
"LEC"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_8037_entity",
"type": "progene_text",
"text": [
"CCR5"
],
"offsets": [
[
68,
72
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4982
|
split_0_train_4982
|
[
{
"id": "split_0_train_4982_passage",
"type": "progene_text",
"text": [
"Consistently , LEC was found to bind to CCR1 , CCR2 and CCR5 with relatively low affinities ."
],
"offsets": [
[
0,
93
]
]
}
] |
[
{
"id": "split_0_train_8038_entity",
"type": "progene_text",
"text": [
"LEC"
],
"offsets": [
[
15,
18
]
],
"normalized": []
},
{
"id": "split_0_train_8039_entity",
"type": "progene_text",
"text": [
"CCR1"
],
"offsets": [
[
40,
44
]
],
"normalized": []
},
{
"id": "split_0_train_8040_entity",
"type": "progene_text",
"text": [
"CCR2"
],
"offsets": [
[
47,
51
]
],
"normalized": []
},
{
"id": "split_0_train_8041_entity",
"type": "progene_text",
"text": [
"CCR5"
],
"offsets": [
[
56,
60
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4983
|
split_0_train_4983
|
[
{
"id": "split_0_train_4983_passage",
"type": "progene_text",
"text": [
"The binding of LEC to CCR8 was much less significant ."
],
"offsets": [
[
0,
54
]
]
}
] |
[
{
"id": "split_0_train_8042_entity",
"type": "progene_text",
"text": [
"LEC"
],
"offsets": [
[
15,
18
]
],
"normalized": []
},
{
"id": "split_0_train_8043_entity",
"type": "progene_text",
"text": [
"CCR8"
],
"offsets": [
[
22,
26
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4984
|
split_0_train_4984
|
[
{
"id": "split_0_train_4984_passage",
"type": "progene_text",
"text": [
"In spite of its binding to CCR5 , LEC was unable to inhibit infection of an R5 - type HIV-1 to activated human peripheral blood mononuclear cells even at high concentrations ."
],
"offsets": [
[
0,
175
]
]
}
] |
[
{
"id": "split_0_train_8044_entity",
"type": "progene_text",
"text": [
"CCR5"
],
"offsets": [
[
27,
31
]
],
"normalized": []
},
{
"id": "split_0_train_8045_entity",
"type": "progene_text",
"text": [
"LEC"
],
"offsets": [
[
34,
37
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4985
|
split_0_train_4985
|
[
{
"id": "split_0_train_4985_passage",
"type": "progene_text",
"text": [
"In human liver sections , hepatocytes were strongly stained by anti - LEC antibody ."
],
"offsets": [
[
0,
84
]
]
}
] |
[
{
"id": "split_0_train_8046_entity",
"type": "progene_text",
"text": [
"LEC"
],
"offsets": [
[
70,
73
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4986
|
split_0_train_4986
|
[
{
"id": "split_0_train_4986_passage",
"type": "progene_text",
"text": [
"HepG2 , a human hepatocarcinoma cell line , was found to constitutively express LEC ."
],
"offsets": [
[
0,
85
]
]
}
] |
[
{
"id": "split_0_train_8047_entity",
"type": "progene_text",
"text": [
"LEC"
],
"offsets": [
[
80,
83
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4987
|
split_0_train_4987
|
[
{
"id": "split_0_train_4987_passage",
"type": "progene_text",
"text": [
"LEC was also present in the plasma samples from healthy adult donors at relatively high concentrations ( 0.3 -- 4 nM ) ."
],
"offsets": [
[
0,
120
]
]
}
] |
[
{
"id": "split_0_train_8048_entity",
"type": "progene_text",
"text": [
"LEC"
],
"offsets": [
[
0,
3
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4988
|
split_0_train_4988
|
[
{
"id": "split_0_train_4988_passage",
"type": "progene_text",
"text": [
"Taken together , LEC is a new low - affinity functional ligand for CCR1 , CCR2 and CCR5 , and is constitutively expressed by liver parenchymal cells ."
],
"offsets": [
[
0,
150
]
]
}
] |
[
{
"id": "split_0_train_8049_entity",
"type": "progene_text",
"text": [
"LEC"
],
"offsets": [
[
17,
20
]
],
"normalized": []
},
{
"id": "split_0_train_8050_entity",
"type": "progene_text",
"text": [
"CCR1"
],
"offsets": [
[
67,
71
]
],
"normalized": []
},
{
"id": "split_0_train_8051_entity",
"type": "progene_text",
"text": [
"CCR2"
],
"offsets": [
[
74,
78
]
],
"normalized": []
},
{
"id": "split_0_train_8052_entity",
"type": "progene_text",
"text": [
"CCR5"
],
"offsets": [
[
83,
87
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4989
|
split_0_train_4989
|
[
{
"id": "split_0_train_4989_passage",
"type": "progene_text",
"text": [
"The presence of LEC in normal plasma at relatively high concentrations may modulate inflammatory responses ."
],
"offsets": [
[
0,
108
]
]
}
] |
[
{
"id": "split_0_train_8053_entity",
"type": "progene_text",
"text": [
"LEC"
],
"offsets": [
[
16,
19
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4990
|
split_0_train_4990
|
[
{
"id": "split_0_train_4990_passage",
"type": "progene_text",
"text": [
"Sulfonate - sulfur metabolism and its regulation in Escherichia coli ."
],
"offsets": [
[
0,
70
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4991
|
split_0_train_4991
|
[
{
"id": "split_0_train_4991_passage",
"type": "progene_text",
"text": [
"In the absence of sulfate and cysteine , Escherichia coli can use aliphatic sulfonates as a source of sulfur for growth ."
],
"offsets": [
[
0,
121
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4992
|
split_0_train_4992
|
[
{
"id": "split_0_train_4992_passage",
"type": "progene_text",
"text": [
"Starvation for sulfate leads to the expression of the tauABCD and ssuEADCB genes ."
],
"offsets": [
[
0,
82
]
]
}
] |
[
{
"id": "split_0_train_8054_entity",
"type": "progene_text",
"text": [
"tauABCD"
],
"offsets": [
[
54,
61
]
],
"normalized": []
},
{
"id": "split_0_train_8055_entity",
"type": "progene_text",
"text": [
"ssuEADCB"
],
"offsets": [
[
66,
74
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4993
|
split_0_train_4993
|
[
{
"id": "split_0_train_4993_passage",
"type": "progene_text",
"text": [
"Each of these gene clusters encodes an ABC - type transport system required for uptake of aliphatic sulfonates and a desulfonation enzyme ."
],
"offsets": [
[
0,
139
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4994
|
split_0_train_4994
|
[
{
"id": "split_0_train_4994_passage",
"type": "progene_text",
"text": [
"The TauD protein is an alpha-ketoglutarate - dependent dioxygenase that preferentially liberates sulfite from taurine ( 2-aminoethanesulfonic acid ) ."
],
"offsets": [
[
0,
150
]
]
}
] |
[
{
"id": "split_0_train_8056_entity",
"type": "progene_text",
"text": [
"TauD"
],
"offsets": [
[
4,
8
]
],
"normalized": []
},
{
"id": "split_0_train_8057_entity",
"type": "progene_text",
"text": [
"alpha-ketoglutarate - dependent dioxygenase"
],
"offsets": [
[
23,
66
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4995
|
split_0_train_4995
|
[
{
"id": "split_0_train_4995_passage",
"type": "progene_text",
"text": [
"SsuD is a monooxygenase that catalyzes the oxygenolytic desulfonation of a range of aliphatic sulfonates other than taurine ."
],
"offsets": [
[
0,
125
]
]
}
] |
[
{
"id": "split_0_train_8058_entity",
"type": "progene_text",
"text": [
"SsuD"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_8059_entity",
"type": "progene_text",
"text": [
"monooxygenase"
],
"offsets": [
[
10,
23
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4996
|
split_0_train_4996
|
[
{
"id": "split_0_train_4996_passage",
"type": "progene_text",
"text": [
"Its cosubstrate is FMNH2 , which is provided by SsuE , an NAD(P)H - dependent FMN reductase ."
],
"offsets": [
[
0,
93
]
]
}
] |
[
{
"id": "split_0_train_8060_entity",
"type": "progene_text",
"text": [
"SsuE"
],
"offsets": [
[
48,
52
]
],
"normalized": []
},
{
"id": "split_0_train_8061_entity",
"type": "progene_text",
"text": [
"FMN reductase"
],
"offsets": [
[
78,
91
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4997
|
split_0_train_4997
|
[
{
"id": "split_0_train_4997_passage",
"type": "progene_text",
"text": [
"In contrast to many other bacteria , E. coli is unable to grow with arylsulfonates or with sulfate esters as sulfur source ."
],
"offsets": [
[
0,
124
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4998
|
split_0_train_4998
|
[
{
"id": "split_0_train_4998_passage",
"type": "progene_text",
"text": [
"The tau and ssu systems thus provide all genes for the utilization of known organosulfur sources by this organism , except the as yet unidentified gene(s) that enable some E. coli strains to grow with methanesulfonate or cysteate as a sulfur source ."
],
"offsets": [
[
0,
250
]
]
}
] |
[
{
"id": "split_0_train_8062_entity",
"type": "progene_text",
"text": [
"tau"
],
"offsets": [
[
4,
7
]
],
"normalized": []
},
{
"id": "split_0_train_8063_entity",
"type": "progene_text",
"text": [
"ssu"
],
"offsets": [
[
12,
15
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4999
|
split_0_train_4999
|
[
{
"id": "split_0_train_4999_passage",
"type": "progene_text",
"text": [
"Expression of the tau and ssu genes requires the LysR - type transcriptional regulatory proteins CysB and Cbl ."
],
"offsets": [
[
0,
111
]
]
}
] |
[
{
"id": "split_0_train_8064_entity",
"type": "progene_text",
"text": [
"tau"
],
"offsets": [
[
18,
21
]
],
"normalized": []
},
{
"id": "split_0_train_8065_entity",
"type": "progene_text",
"text": [
"ssu"
],
"offsets": [
[
26,
29
]
],
"normalized": []
},
{
"id": "split_0_train_8066_entity",
"type": "progene_text",
"text": [
"LysR"
],
"offsets": [
[
49,
53
]
],
"normalized": []
},
{
"id": "split_0_train_8067_entity",
"type": "progene_text",
"text": [
"CysB"
],
"offsets": [
[
97,
101
]
],
"normalized": []
},
{
"id": "split_0_train_8068_entity",
"type": "progene_text",
"text": [
"Cbl"
],
"offsets": [
[
106,
109
]
],
"normalized": []
}
] |
[] |
[] |
[] |
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