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split_0_train_4700
split_0_train_4700
[ { "id": "split_0_train_4700_passage", "type": "progene_text", "text": [ "Removal of A antigen with alpha-N-acetylgalactosaminidase or B antigen with alpha-galactosidase did not affect its multimer size or antigenic level , but decreased the ristocetin cofactor ( RCoF ) activity of the respective VWF by 33 - 39 % ( P < 0.01 - 0.002 ) ." ], "offsets": [ [ 0, 263 ] ] } ]
[ { "id": "split_0_train_7412_entity", "type": "progene_text", "text": [ "alpha-N-acetylgalactosaminidase" ], "offsets": [ [ 26, 57 ] ], "normalized": [] }, { "id": "split_0_train_7413_entity", "type": "progene_text", "text": [ "alpha-galactosidase" ], "offsets": [ [ 76, 95 ] ], "normalized": [] }, { "id": "split_0_train_7414_entity", "type": "progene_text", "text": [ "VWF" ], "offsets": [ [ 224, 227 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4701
split_0_train_4701
[ { "id": "split_0_train_4701_passage", "type": "progene_text", "text": [ "Removal of A or B antigen from VWF did not affect the binding of the VWF to immobilized type III collagen ." ], "offsets": [ [ 0, 107 ] ] } ]
[ { "id": "split_0_train_7415_entity", "type": "progene_text", "text": [ "VWF" ], "offsets": [ [ 31, 34 ] ], "normalized": [] }, { "id": "split_0_train_7416_entity", "type": "progene_text", "text": [ "VWF" ], "offsets": [ [ 69, 72 ] ], "normalized": [] }, { "id": "split_0_train_7417_entity", "type": "progene_text", "text": [ "type III collagen" ], "offsets": [ [ 88, 105 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4702
split_0_train_4702
[ { "id": "split_0_train_4702_passage", "type": "progene_text", "text": [ "A and B antigens were not detected in platelet VWF ." ], "offsets": [ [ 0, 52 ] ] } ]
[ { "id": "split_0_train_7418_entity", "type": "progene_text", "text": [ "VWF" ], "offsets": [ [ 47, 50 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4703
split_0_train_4703
[ { "id": "split_0_train_4703_passage", "type": "progene_text", "text": [ "These results indicate that AB structures play a role in platelet aggregating activity of VWF ." ], "offsets": [ [ 0, 95 ] ] } ]
[ { "id": "split_0_train_7419_entity", "type": "progene_text", "text": [ "VWF" ], "offsets": [ [ 90, 93 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4704
split_0_train_4704
[ { "id": "split_0_train_4704_passage", "type": "progene_text", "text": [ "ApoE polymorphism and fish oil supplementation in subjects with an atherogenic lipoprotein phenotype ." ], "offsets": [ [ 0, 102 ] ] } ]
[ { "id": "split_0_train_7420_entity", "type": "progene_text", "text": [ "ApoE" ], "offsets": [ [ 0, 4 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4705
split_0_train_4705
[ { "id": "split_0_train_4705_passage", "type": "progene_text", "text": [ "The study assessed the efficacy of fish oil supplementation in counteracting the classic dyslipidemia of the atherogenic lipoprotein phenotype ( ALP ) ." ], "offsets": [ [ 0, 152 ] ] } ]
[]
[]
[]
[]
split_0_train_4706
split_0_train_4706
[ { "id": "split_0_train_4706_passage", "type": "progene_text", "text": [ "In addition , the impact of the common apolipoprotein E ( apoE ) polymorphism on the fasting and postprandial lipid profile and on responsiveness to the dietary intervention was established ." ], "offsets": [ [ 0, 191 ] ] } ]
[ { "id": "split_0_train_7421_entity", "type": "progene_text", "text": [ "apolipoprotein E" ], "offsets": [ [ 39, 55 ] ], "normalized": [] }, { "id": "split_0_train_7422_entity", "type": "progene_text", "text": [ "apoE" ], "offsets": [ [ 58, 62 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4707
split_0_train_4707
[ { "id": "split_0_train_4707_passage", "type": "progene_text", "text": [ "Fifty - five ALP males ( aged 34 to 69 years , body mass index 22 to 35 kg / m(2) , triglyceride [ TG ] levels 1.5 to 4.0 mmol / L , high density lipoprotein cholesterol [ HDL - C ] < 1.1 mmol / l , and percent low density lipoprotein [LDL]-3 > 40 % total LDL ) completed a randomized placebo - controlled crossover trial of fish oil ( 3.0 g eicosapentaenoic acid / docosahexaenoic acid per day ) and placebo ( olive oil ) capsules with the 6 - week treatment arms separated by a 12 - week washout period ." ], "offsets": [ [ 0, 506 ] ] } ]
[ { "id": "split_0_train_7423_entity", "type": "progene_text", "text": [ "high density lipoprotein" ], "offsets": [ [ 133, 157 ] ], "normalized": [] }, { "id": "split_0_train_7424_entity", "type": "progene_text", "text": [ "HDL" ], "offsets": [ [ 172, 175 ] ], "normalized": [] }, { "id": "split_0_train_7425_entity", "type": "progene_text", "text": [ "low density lipoprotein [LDL]-3" ], "offsets": [ [ 211, 242 ] ], "normalized": [] }, { "id": "split_0_train_7426_entity", "type": "progene_text", "text": [ "LDL" ], "offsets": [ [ 256, 259 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4708
split_0_train_4708
[ { "id": "split_0_train_4708_passage", "type": "progene_text", "text": [ "In addition to fasting blood samples , at the end of each intervention arm , a postprandial assessment of lipid metabolism was carried out ." ], "offsets": [ [ 0, 140 ] ] } ]
[]
[]
[]
[]
split_0_train_4709
split_0_train_4709
[ { "id": "split_0_train_4709_passage", "type": "progene_text", "text": [ "Fish oil supplementation resulted in a reduction in fasting TG level of 35 % ( P < 0.001 ) , in postprandial TG response of 26 % ( TG area under the curve , P < 0.001 ) , and in percent LDL-3 of 26 % ( P < 0.05 ) ." ], "offsets": [ [ 0, 214 ] ] } ]
[ { "id": "split_0_train_7427_entity", "type": "progene_text", "text": [ "LDL-3" ], "offsets": [ [ 186, 191 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4710
split_0_train_4710
[ { "id": "split_0_train_4710_passage", "type": "progene_text", "text": [ "However , no change in HDL - C levels was evident ( P = 0.752 ) ." ], "offsets": [ [ 0, 65 ] ] } ]
[ { "id": "split_0_train_7428_entity", "type": "progene_text", "text": [ "HDL" ], "offsets": [ [ 23, 26 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4711
split_0_train_4711
[ { "id": "split_0_train_4711_passage", "type": "progene_text", "text": [ "ANCOVA showed that baseline HDL - C levels were significantly lower in apoE4 carriers ( P = 0.035 ) ." ], "offsets": [ [ 0, 101 ] ] } ]
[ { "id": "split_0_train_7429_entity", "type": "progene_text", "text": [ "HDL" ], "offsets": [ [ 28, 31 ] ], "normalized": [] }, { "id": "split_0_train_7430_entity", "type": "progene_text", "text": [ "apoE4" ], "offsets": [ [ 71, 76 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4712
split_0_train_4712
[ { "id": "split_0_train_4712_passage", "type": "progene_text", "text": [ "The apoE genotype also had a striking impact on lipid responses to fish oil intervention ." ], "offsets": [ [ 0, 90 ] ] } ]
[ { "id": "split_0_train_7431_entity", "type": "progene_text", "text": [ "apoE" ], "offsets": [ [ 4, 8 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4713
split_0_train_4713
[ { "id": "split_0_train_4713_passage", "type": "progene_text", "text": [ "Individuals with an apoE2 allele displayed a marked reduction in postprandial incremental TG response ( TG incremental area under the curve , P = 0.023 ) and a trend toward an increase in lipoprotein lipase activity relative to non - E2 carriers ." ], "offsets": [ [ 0, 247 ] ] } ]
[ { "id": "split_0_train_7432_entity", "type": "progene_text", "text": [ "apoE2" ], "offsets": [ [ 20, 25 ] ], "normalized": [] }, { "id": "split_0_train_7433_entity", "type": "progene_text", "text": [ "lipoprotein lipase" ], "offsets": [ [ 188, 206 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4714
split_0_train_4714
[ { "id": "split_0_train_4714_passage", "type": "progene_text", "text": [ "In apoE4 individuals , a significant increase in total cholesterol and a trend toward a reduction in HDL - C relative to the common homozygous E3 / E3 profile was evident ." ], "offsets": [ [ 0, 172 ] ] } ]
[ { "id": "split_0_train_7434_entity", "type": "progene_text", "text": [ "apoE4" ], "offsets": [ [ 3, 8 ] ], "normalized": [] }, { "id": "split_0_train_7435_entity", "type": "progene_text", "text": [ "HDL" ], "offsets": [ [ 101, 104 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4715
split_0_train_4715
[ { "id": "split_0_train_4715_passage", "type": "progene_text", "text": [ "Our data demonstrate the efficacy of fish oil fatty acids in counteracting the proatherogenic lipid profile of the ALP but also that the apoE genotype influences responsiveness to this dietary treatment ." ], "offsets": [ [ 0, 204 ] ] } ]
[ { "id": "split_0_train_7436_entity", "type": "progene_text", "text": [ "apoE" ], "offsets": [ [ 137, 141 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4716
split_0_train_4716
[ { "id": "split_0_train_4716_passage", "type": "progene_text", "text": [ "The impact of the ovulatory cycle on cytokine production : evaluation of systemic , cervicovaginal , and salivary compartments ." ], "offsets": [ [ 0, 128 ] ] } ]
[ { "id": "split_0_train_7437_entity", "type": "progene_text", "text": [ "cytokine" ], "offsets": [ [ 37, 45 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4717
split_0_train_4717
[ { "id": "split_0_train_4717_passage", "type": "progene_text", "text": [ "To understand the impact of the menstrual cycle on immunologic parameters , we measured the level of cytokines and chemokines from plasma , cervicovaginal lavage ( CVL ) , and saliva samples of 6 premenopausal women during the follicular and luteal phases of the ovulatory cycle ." ], "offsets": [ [ 0, 280 ] ] } ]
[ { "id": "split_0_train_7438_entity", "type": "progene_text", "text": [ "cytokines" ], "offsets": [ [ 101, 110 ] ], "normalized": [] }, { "id": "split_0_train_7439_entity", "type": "progene_text", "text": [ "chemokines" ], "offsets": [ [ 115, 125 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4718
split_0_train_4718
[ { "id": "split_0_train_4718_passage", "type": "progene_text", "text": [ "We demonstrate that the level of plasma interleukin-8 ( IL-8 ) was 4 - fold higher during the follicular phase than the luteal phase ( p = 0.004 ) , whereas plasma IL-1beta , IL-4 , IL-6 , IL-10 , interferon-gamma ( IFN-gamma ) , transforming growth factor - beta ( TGF-beta ) , tumor necrosis factor - alpha ( TNF-alpha ) , macrophage inflammatory protein-1alpha ( MIP-1alpha ) , and TNF receptor II ( TNFR II ) were not altered during the ovulatory cycle ." ], "offsets": [ [ 0, 458 ] ] } ]
[ { "id": "split_0_train_7440_entity", "type": "progene_text", "text": [ "interleukin-8" ], "offsets": [ [ 40, 53 ] ], "normalized": [] }, { "id": "split_0_train_7441_entity", "type": "progene_text", "text": [ "IL-8" ], "offsets": [ [ 56, 60 ] ], "normalized": [] }, { "id": "split_0_train_7442_entity", "type": "progene_text", "text": [ "IL-1beta" ], "offsets": [ [ 164, 172 ] ], "normalized": [] }, { "id": "split_0_train_7443_entity", "type": "progene_text", "text": [ "IL-4" ], "offsets": [ [ 175, 179 ] ], "normalized": [] }, { "id": "split_0_train_7444_entity", "type": "progene_text", "text": [ "IL-6" ], "offsets": [ [ 182, 186 ] ], "normalized": [] }, { "id": "split_0_train_7445_entity", "type": "progene_text", "text": [ "IL-10" ], "offsets": [ [ 189, 194 ] ], "normalized": [] }, { "id": "split_0_train_7446_entity", "type": "progene_text", "text": [ "interferon-gamma" ], "offsets": [ [ 197, 213 ] ], "normalized": [] }, { "id": "split_0_train_7447_entity", "type": "progene_text", "text": [ "IFN-gamma" ], "offsets": [ [ 216, 225 ] ], "normalized": [] }, { "id": "split_0_train_7448_entity", "type": "progene_text", "text": [ "transforming growth factor - beta" ], "offsets": [ [ 230, 263 ] ], "normalized": [] }, { "id": "split_0_train_7449_entity", "type": "progene_text", "text": [ "TGF-beta" ], "offsets": [ [ 266, 274 ] ], "normalized": [] }, { "id": "split_0_train_7450_entity", "type": "progene_text", "text": [ "tumor necrosis factor - alpha" ], "offsets": [ [ 279, 308 ] ], "normalized": [] }, { "id": "split_0_train_7451_entity", "type": "progene_text", "text": [ "TNF-alpha" ], "offsets": [ [ 311, 320 ] ], "normalized": [] }, { "id": "split_0_train_7452_entity", "type": "progene_text", "text": [ "macrophage inflammatory protein-1alpha" ], "offsets": [ [ 325, 363 ] ], "normalized": [] }, { "id": "split_0_train_7453_entity", "type": "progene_text", "text": [ "MIP-1alpha" ], "offsets": [ [ 366, 376 ] ], "normalized": [] }, { "id": "split_0_train_7454_entity", "type": "progene_text", "text": [ "TNF receptor II" ], "offsets": [ [ 385, 400 ] ], "normalized": [] }, { "id": "split_0_train_7455_entity", "type": "progene_text", "text": [ "TNFR II" ], "offsets": [ [ 403, 410 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4719
split_0_train_4719
[ { "id": "split_0_train_4719_passage", "type": "progene_text", "text": [ "In the vaginal compartment , as measured from CVL samples , the levels of IL-6 and IL-1beta were both 5 - fold higher in the follicular than the luteal phase ( p = 0.0002 and 0.03 , respectively ) ." ], "offsets": [ [ 0, 198 ] ] } ]
[ { "id": "split_0_train_7456_entity", "type": "progene_text", "text": [ "IL-6" ], "offsets": [ [ 74, 78 ] ], "normalized": [] }, { "id": "split_0_train_7457_entity", "type": "progene_text", "text": [ "IL-1beta" ], "offsets": [ [ 83, 91 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4720
split_0_train_4720
[ { "id": "split_0_train_4720_passage", "type": "progene_text", "text": [ "Salivary cytokine and chemokine samples were similar when measured during the luteal and the follicular phases ." ], "offsets": [ [ 0, 112 ] ] } ]
[ { "id": "split_0_train_7458_entity", "type": "progene_text", "text": [ "cytokine" ], "offsets": [ [ 9, 17 ] ], "normalized": [] }, { "id": "split_0_train_7459_entity", "type": "progene_text", "text": [ "chemokine" ], "offsets": [ [ 22, 31 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4721
split_0_train_4721
[ { "id": "split_0_train_4721_passage", "type": "progene_text", "text": [ "Additional analysis of lymphocyte subsets for phenotypic and functional markers indicated that they were not influenced by the ovulatory cycle ." ], "offsets": [ [ 0, 144 ] ] } ]
[]
[]
[]
[]
split_0_train_4722
split_0_train_4722
[ { "id": "split_0_train_4722_passage", "type": "progene_text", "text": [ "Collectively , these data suggest that IL-6 , IL-8 , and IL-1beta are differentially regulated during the ovulatory cycle ." ], "offsets": [ [ 0, 123 ] ] } ]
[ { "id": "split_0_train_7460_entity", "type": "progene_text", "text": [ "IL-6" ], "offsets": [ [ 39, 43 ] ], "normalized": [] }, { "id": "split_0_train_7461_entity", "type": "progene_text", "text": [ "IL-8" ], "offsets": [ [ 46, 50 ] ], "normalized": [] }, { "id": "split_0_train_7462_entity", "type": "progene_text", "text": [ "IL-1beta" ], "offsets": [ [ 57, 65 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4723
split_0_train_4723
[ { "id": "split_0_train_4723_passage", "type": "progene_text", "text": [ "Identification of a common receptor for three types of rat cytokine - induced neutrophil chemoattractants ( CINCs ) ." ], "offsets": [ [ 0, 117 ] ] } ]
[ { "id": "split_0_train_7463_entity", "type": "progene_text", "text": [ "cytokine - induced neutrophil chemoattractants" ], "offsets": [ [ 59, 105 ] ], "normalized": [] }, { "id": "split_0_train_7464_entity", "type": "progene_text", "text": [ "CINCs" ], "offsets": [ [ 108, 113 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4724
split_0_train_4724
[ { "id": "split_0_train_4724_passage", "type": "progene_text", "text": [ "Rat cytokine - induced neutrophil chemoattractant-1 ( CINC-1 ) , CINC-2 and CINC-3 / macrophage inflammatory protein-2 ( MIP-2 ) , members of the CXC chemokine family , are potent chemotactic factors for neutrophils ." ], "offsets": [ [ 0, 217 ] ] } ]
[ { "id": "split_0_train_7465_entity", "type": "progene_text", "text": [ "cytokine - induced neutrophil chemoattractant-1" ], "offsets": [ [ 4, 51 ] ], "normalized": [] }, { "id": "split_0_train_7466_entity", "type": "progene_text", "text": [ "CINC-1" ], "offsets": [ [ 54, 60 ] ], "normalized": [] }, { "id": "split_0_train_7467_entity", "type": "progene_text", "text": [ "CINC-2" ], "offsets": [ [ 65, 71 ] ], "normalized": [] }, { "id": "split_0_train_7468_entity", "type": "progene_text", "text": [ "CINC-3" ], "offsets": [ [ 76, 82 ] ], "normalized": [] }, { "id": "split_0_train_7469_entity", "type": "progene_text", "text": [ "macrophage inflammatory protein-2" ], "offsets": [ [ 85, 118 ] ], "normalized": [] }, { "id": "split_0_train_7470_entity", "type": "progene_text", "text": [ "MIP-2" ], "offsets": [ [ 121, 126 ] ], "normalized": [] }, { "id": "split_0_train_7471_entity", "type": "progene_text", "text": [ "CXC chemokine family" ], "offsets": [ [ 146, 166 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4725
split_0_train_4725
[ { "id": "split_0_train_4725_passage", "type": "progene_text", "text": [ "In order to identify the receptor for CINCs , rat CXC chemokine receptor 2 ( CXCR2 ) was cloned and expressed in HEK293 cells ." ], "offsets": [ [ 0, 127 ] ] } ]
[ { "id": "split_0_train_7472_entity", "type": "progene_text", "text": [ "CINCs" ], "offsets": [ [ 38, 43 ] ], "normalized": [] }, { "id": "split_0_train_7473_entity", "type": "progene_text", "text": [ "CXC chemokine receptor 2" ], "offsets": [ [ 50, 74 ] ], "normalized": [] }, { "id": "split_0_train_7474_entity", "type": "progene_text", "text": [ "CXCR2" ], "offsets": [ [ 77, 82 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4726
split_0_train_4726
[ { "id": "split_0_train_4726_passage", "type": "progene_text", "text": [ "CINC-1 , CINC-2 and CINC-3 induced calcium mobilizations dose - dependently in CXCR2 - transfected cells , whereas formyl-methionyl-leucyl-phenylalanine ( FMLP ) did not ." ], "offsets": [ [ 0, 171 ] ] } ]
[ { "id": "split_0_train_7475_entity", "type": "progene_text", "text": [ "CINC-1" ], "offsets": [ [ 0, 6 ] ], "normalized": [] }, { "id": "split_0_train_7476_entity", "type": "progene_text", "text": [ "CINC-2" ], "offsets": [ [ 9, 15 ] ], "normalized": [] }, { "id": "split_0_train_7477_entity", "type": "progene_text", "text": [ "CINC-3" ], "offsets": [ [ 20, 26 ] ], "normalized": [] }, { "id": "split_0_train_7478_entity", "type": "progene_text", "text": [ "CXCR2" ], "offsets": [ [ 79, 84 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4727
split_0_train_4727
[ { "id": "split_0_train_4727_passage", "type": "progene_text", "text": [ "CINC-3 induced enhancement of cytoplasmic calcium concentration more potently than CINC-1 and CINC-2 , and desensitized calcium transients induced by CINC-1 and CINC-2 , which were essentially identical to those observed in rat neutrophils ." ], "offsets": [ [ 0, 241 ] ] } ]
[ { "id": "split_0_train_7479_entity", "type": "progene_text", "text": [ "CINC-3" ], "offsets": [ [ 0, 6 ] ], "normalized": [] }, { "id": "split_0_train_7480_entity", "type": "progene_text", "text": [ "CINC-1" ], "offsets": [ [ 83, 89 ] ], "normalized": [] }, { "id": "split_0_train_7481_entity", "type": "progene_text", "text": [ "CINC-2" ], "offsets": [ [ 94, 100 ] ], "normalized": [] }, { "id": "split_0_train_7482_entity", "type": "progene_text", "text": [ "CINC-1" ], "offsets": [ [ 150, 156 ] ], "normalized": [] }, { "id": "split_0_train_7483_entity", "type": "progene_text", "text": [ "CINC-2" ], "offsets": [ [ 161, 167 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4728
split_0_train_4728
[ { "id": "split_0_train_4728_passage", "type": "progene_text", "text": [ "In addition , anti - CXCR2 serum inhibited neutrophil chemotactic activities of three types of CINCs almost completely ." ], "offsets": [ [ 0, 120 ] ] } ]
[ { "id": "split_0_train_7484_entity", "type": "progene_text", "text": [ "CXCR2" ], "offsets": [ [ 21, 26 ] ], "normalized": [] }, { "id": "split_0_train_7485_entity", "type": "progene_text", "text": [ "CINCs" ], "offsets": [ [ 95, 100 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4729
split_0_train_4729
[ { "id": "split_0_train_4729_passage", "type": "progene_text", "text": [ "The mutant CINC-3 , whose amino - terminal amino acid sequence ( SELR ) was replaced to AAR , lost chemotactic activity of its own but inhibited that of CINC-1 and CINC-2 potently , and that of CINC-3 weakly ." ], "offsets": [ [ 0, 209 ] ] } ]
[ { "id": "split_0_train_7486_entity", "type": "progene_text", "text": [ "CINC-3" ], "offsets": [ [ 11, 17 ] ], "normalized": [] }, { "id": "split_0_train_7487_entity", "type": "progene_text", "text": [ "CINC-1" ], "offsets": [ [ 153, 159 ] ], "normalized": [] }, { "id": "split_0_train_7488_entity", "type": "progene_text", "text": [ "CINC-2" ], "offsets": [ [ 164, 170 ] ], "normalized": [] }, { "id": "split_0_train_7489_entity", "type": "progene_text", "text": [ "CINC-3" ], "offsets": [ [ 194, 200 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4730
split_0_train_4730
[ { "id": "split_0_train_4730_passage", "type": "progene_text", "text": [ "The results indicate that rat CXCR2 on neutrophils is the unique receptor for all three types of CINCs , and CINC-1 / - 2 and CINC-3 exert different biological activities through the common receptor ." ], "offsets": [ [ 0, 200 ] ] } ]
[ { "id": "split_0_train_7490_entity", "type": "progene_text", "text": [ "CXCR2" ], "offsets": [ [ 30, 35 ] ], "normalized": [] }, { "id": "split_0_train_7491_entity", "type": "progene_text", "text": [ "CINCs" ], "offsets": [ [ 97, 102 ] ], "normalized": [] }, { "id": "split_0_train_7492_entity", "type": "progene_text", "text": [ "CINC-1 / - 2" ], "offsets": [ [ 109, 121 ] ], "normalized": [] }, { "id": "split_0_train_7493_entity", "type": "progene_text", "text": [ "CINC-3" ], "offsets": [ [ 126, 132 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4731
split_0_train_4731
[ { "id": "split_0_train_4731_passage", "type": "progene_text", "text": [ "ASD4 , a new GATA factor of Neurospora crassa , displays sequence - specific DNA binding and functions in ascus and ascospore development ." ], "offsets": [ [ 0, 139 ] ] } ]
[ { "id": "split_0_train_7494_entity", "type": "progene_text", "text": [ "ASD4" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "split_0_train_7495_entity", "type": "progene_text", "text": [ "GATA factor" ], "offsets": [ [ 13, 24 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4732
split_0_train_4732
[ { "id": "split_0_train_4732_passage", "type": "progene_text", "text": [ "A new gene encoding a novel GATA factor , ASD4 , of Neurospora crassa was isolated and demonstrated to possess one intron and to specify an open reading frame encoding a protein with 427 amino acid residues ." ], "offsets": [ [ 0, 208 ] ] } ]
[ { "id": "split_0_train_7496_entity", "type": "progene_text", "text": [ "GATA factor" ], "offsets": [ [ 28, 39 ] ], "normalized": [] }, { "id": "split_0_train_7497_entity", "type": "progene_text", "text": [ "ASD4" ], "offsets": [ [ 42, 46 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4733
split_0_train_4733
[ { "id": "split_0_train_4733_passage", "type": "progene_text", "text": [ "The ASD4 protein contains a single GATA - type zinc finger and a putative coiled - coil domain ." ], "offsets": [ [ 0, 96 ] ] } ]
[ { "id": "split_0_train_7498_entity", "type": "progene_text", "text": [ "ASD4" ], "offsets": [ [ 4, 8 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4734
split_0_train_4734
[ { "id": "split_0_train_4734_passage", "type": "progene_text", "text": [ "Unlike related proteins , DAL80 in yeast and NREB in Penicillium , ASD4 does not appear to be involved in regulation of nitrogen metabolism ." ], "offsets": [ [ 0, 141 ] ] } ]
[ { "id": "split_0_train_7499_entity", "type": "progene_text", "text": [ "DAL80" ], "offsets": [ [ 26, 31 ] ], "normalized": [] }, { "id": "split_0_train_7500_entity", "type": "progene_text", "text": [ "NREB" ], "offsets": [ [ 45, 49 ] ], "normalized": [] }, { "id": "split_0_train_7501_entity", "type": "progene_text", "text": [ "ASD4" ], "offsets": [ [ 67, 71 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4735
split_0_train_4735
[ { "id": "split_0_train_4735_passage", "type": "progene_text", "text": [ "An Asd-4 null mutant obtained by the rip procedure did not show any effect upon nitrogen control , but instead resulted in severe defects in ascus and ascospore genesis ." ], "offsets": [ [ 0, 170 ] ] } ]
[ { "id": "split_0_train_7502_entity", "type": "progene_text", "text": [ "Asd-4" ], "offsets": [ [ 3, 8 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4736
split_0_train_4736
[ { "id": "split_0_train_4736_passage", "type": "progene_text", "text": [ "The Asd-4 rip mutant is dominant to Asd-4 + ." ], "offsets": [ [ 0, 45 ] ] } ]
[ { "id": "split_0_train_7503_entity", "type": "progene_text", "text": [ "Asd-4" ], "offsets": [ [ 4, 9 ] ], "normalized": [] }, { "id": "split_0_train_7504_entity", "type": "progene_text", "text": [ "Asd-4" ], "offsets": [ [ 36, 41 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4737
split_0_train_4737
[ { "id": "split_0_train_4737_passage", "type": "progene_text", "text": [ "A cross of the Asd-4 mutant with wild - type resulted in fruiting bodies that appeared to be normal macroscopically but which were complete devoid of asci and ascospores ." ], "offsets": [ [ 0, 171 ] ] } ]
[ { "id": "split_0_train_7505_entity", "type": "progene_text", "text": [ "Asd-4" ], "offsets": [ [ 15, 20 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4738
split_0_train_4738
[ { "id": "split_0_train_4738_passage", "type": "progene_text", "text": [ "Introduction of the Asd-4 + gene into the Asd-4 rip mutant corrected the defect in ascus and ascospore development in crosses with wild - type ." ], "offsets": [ [ 0, 144 ] ] } ]
[ { "id": "split_0_train_7506_entity", "type": "progene_text", "text": [ "Asd-4" ], "offsets": [ [ 20, 25 ] ], "normalized": [] }, { "id": "split_0_train_7507_entity", "type": "progene_text", "text": [ "Asd-4" ], "offsets": [ [ 42, 47 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4739
split_0_train_4739
[ { "id": "split_0_train_4739_passage", "type": "progene_text", "text": [ "Mobility shift assays demonstrated that ASD4 acts as a sequence - specific DNA binding protein and recognizes DNA fragments that contain GATA core elements ." ], "offsets": [ [ 0, 157 ] ] } ]
[ { "id": "split_0_train_7508_entity", "type": "progene_text", "text": [ "ASD4" ], "offsets": [ [ 40, 44 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4740
split_0_train_4740
[ { "id": "split_0_train_4740_passage", "type": "progene_text", "text": [ "Gel filtration and cross - linking experiments revealed that the ASD4 protein exists as a tetramer in solution ." ], "offsets": [ [ 0, 112 ] ] } ]
[ { "id": "split_0_train_7509_entity", "type": "progene_text", "text": [ "ASD4" ], "offsets": [ [ 65, 69 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4741
split_0_train_4741
[ { "id": "split_0_train_4741_passage", "type": "progene_text", "text": [ "These results suggest that the ASD4 protein functions positively as a transcriptional regulator of sexual development in Neurospora ." ], "offsets": [ [ 0, 133 ] ] } ]
[ { "id": "split_0_train_7510_entity", "type": "progene_text", "text": [ "ASD4" ], "offsets": [ [ 31, 35 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4742
split_0_train_4742
[ { "id": "split_0_train_4742_passage", "type": "progene_text", "text": [ "Expression of the ftsY gene , encoding a homologue of the alpha subunit of mammalian signal recognition particle receptor , is controlled by different promoters in vegetative and sporulating cells of Bacillus subtilis ." ], "offsets": [ [ 0, 219 ] ] } ]
[ { "id": "split_0_train_7511_entity", "type": "progene_text", "text": [ "ftsY" ], "offsets": [ [ 18, 22 ] ], "normalized": [] }, { "id": "split_0_train_7512_entity", "type": "progene_text", "text": [ "signal recognition particle receptor" ], "offsets": [ [ 85, 121 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4743
split_0_train_4743
[ { "id": "split_0_train_4743_passage", "type": "progene_text", "text": [ "Bacillus subtilis FtsY ( Srb ) is a homologue of the alpha subunit of the receptor for mammalian signal - recognition particle ( SRP ) and is essential for protein secretion and vegetative cell growth ." ], "offsets": [ [ 0, 202 ] ] } ]
[ { "id": "split_0_train_7513_entity", "type": "progene_text", "text": [ "FtsY" ], "offsets": [ [ 18, 22 ] ], "normalized": [] }, { "id": "split_0_train_7514_entity", "type": "progene_text", "text": [ "Srb" ], "offsets": [ [ 25, 28 ] ], "normalized": [] }, { "id": "split_0_train_7515_entity", "type": "progene_text", "text": [ "signal - recognition particle" ], "offsets": [ [ 97, 126 ] ], "normalized": [] }, { "id": "split_0_train_7516_entity", "type": "progene_text", "text": [ "SRP" ], "offsets": [ [ 129, 132 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4744
split_0_train_4744
[ { "id": "split_0_train_4744_passage", "type": "progene_text", "text": [ "The ftsY gene is expressed during both the exponential phase and sporulation ." ], "offsets": [ [ 0, 78 ] ] } ]
[ { "id": "split_0_train_7517_entity", "type": "progene_text", "text": [ "ftsY" ], "offsets": [ [ 4, 8 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4745
split_0_train_4745
[ { "id": "split_0_train_4745_passage", "type": "progene_text", "text": [ "In vegetative cells , ftsY is transcribed with two upstream genes , rncS and smc , that are under the control of the major transcription factor sigma ( A ) ." ], "offsets": [ [ 0, 157 ] ] } ]
[ { "id": "split_0_train_7518_entity", "type": "progene_text", "text": [ "ftsY" ], "offsets": [ [ 22, 26 ] ], "normalized": [] }, { "id": "split_0_train_7519_entity", "type": "progene_text", "text": [ "rncS" ], "offsets": [ [ 68, 72 ] ], "normalized": [] }, { "id": "split_0_train_7520_entity", "type": "progene_text", "text": [ "smc" ], "offsets": [ [ 77, 80 ] ], "normalized": [] }, { "id": "split_0_train_7521_entity", "type": "progene_text", "text": [ "transcription factor" ], "offsets": [ [ 123, 143 ] ], "normalized": [] }, { "id": "split_0_train_7522_entity", "type": "progene_text", "text": [ "sigma ( A )" ], "offsets": [ [ 144, 155 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4746
split_0_train_4746
[ { "id": "split_0_train_4746_passage", "type": "progene_text", "text": [ "During sporulation , Northern hybridization detected ftsY mRNA in wild - type cells , but not in sporulating cells of sigma ( K ) and gerE mutants ." ], "offsets": [ [ 0, 148 ] ] } ]
[ { "id": "split_0_train_7523_entity", "type": "progene_text", "text": [ "ftsY" ], "offsets": [ [ 53, 57 ] ], "normalized": [] }, { "id": "split_0_train_7524_entity", "type": "progene_text", "text": [ "sigma ( K )" ], "offsets": [ [ 118, 129 ] ], "normalized": [] }, { "id": "split_0_train_7525_entity", "type": "progene_text", "text": [ "gerE" ], "offsets": [ [ 134, 138 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4747
split_0_train_4747
[ { "id": "split_0_train_4747_passage", "type": "progene_text", "text": [ "Therefore , ftsY is solely expressed during sporulation from a sigma ( K ) - and GerE - controlled promoter that is located immediately upstream of ftsY inside the smc gene ." ], "offsets": [ [ 0, 174 ] ] } ]
[ { "id": "split_0_train_7526_entity", "type": "progene_text", "text": [ "ftsY" ], "offsets": [ [ 12, 16 ] ], "normalized": [] }, { "id": "split_0_train_7527_entity", "type": "progene_text", "text": [ "sigma ( K )" ], "offsets": [ [ 63, 74 ] ], "normalized": [] }, { "id": "split_0_train_7528_entity", "type": "progene_text", "text": [ "GerE" ], "offsets": [ [ 81, 85 ] ], "normalized": [] }, { "id": "split_0_train_7529_entity", "type": "progene_text", "text": [ "ftsY" ], "offsets": [ [ 148, 152 ] ], "normalized": [] }, { "id": "split_0_train_7530_entity", "type": "progene_text", "text": [ "smc" ], "offsets": [ [ 164, 167 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4748
split_0_train_4748
[ { "id": "split_0_train_4748_passage", "type": "progene_text", "text": [ "To examine the role of FtsY during sporulation , the B. subtilis strain ISR39 was constructed , a ftsY conditional mutant in which ftsY expression can be shut off during spore formation but not during the vegetative state ." ], "offsets": [ [ 0, 223 ] ] } ]
[ { "id": "split_0_train_7531_entity", "type": "progene_text", "text": [ "FtsY" ], "offsets": [ [ 23, 27 ] ], "normalized": [] }, { "id": "split_0_train_7532_entity", "type": "progene_text", "text": [ "ftsY" ], "offsets": [ [ 98, 102 ] ], "normalized": [] }, { "id": "split_0_train_7533_entity", "type": "progene_text", "text": [ "ftsY" ], "offsets": [ [ 131, 135 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4749
split_0_train_4749
[ { "id": "split_0_train_4749_passage", "type": "progene_text", "text": [ "Electron microscopy showed that the outer coat of ISR39 spores was not completely assembled and immunoelectron microscopy localized FtsY to the inner and outer coats of wild - type spores ." ], "offsets": [ [ 0, 189 ] ] } ]
[ { "id": "split_0_train_7534_entity", "type": "progene_text", "text": [ "FtsY" ], "offsets": [ [ 132, 136 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4750
split_0_train_4750
[ { "id": "split_0_train_4750_passage", "type": "progene_text", "text": [ "Inhalation of toluene diisocyanate affects cytochrome P450 2B1 expression in rat lung ." ], "offsets": [ [ 0, 87 ] ] } ]
[ { "id": "split_0_train_7535_entity", "type": "progene_text", "text": [ "cytochrome P450 2B1" ], "offsets": [ [ 43, 62 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4751
split_0_train_4751
[ { "id": "split_0_train_4751_passage", "type": "progene_text", "text": [ "In the lung the expression of xenobiotic - metabolizing enzymes such as cytochromes P450 ( CYP ) and glutathione S-transferases ( GST ) may be affected by inhaled pollutants ." ], "offsets": [ [ 0, 175 ] ] } ]
[ { "id": "split_0_train_7536_entity", "type": "progene_text", "text": [ "cytochromes P450" ], "offsets": [ [ 72, 88 ] ], "normalized": [] }, { "id": "split_0_train_7537_entity", "type": "progene_text", "text": [ "CYP" ], "offsets": [ [ 91, 94 ] ], "normalized": [] }, { "id": "split_0_train_7538_entity", "type": "progene_text", "text": [ "glutathione S-transferases" ], "offsets": [ [ 101, 127 ] ], "normalized": [] }, { "id": "split_0_train_7539_entity", "type": "progene_text", "text": [ "GST" ], "offsets": [ [ 130, 133 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4752
split_0_train_4752
[ { "id": "split_0_train_4752_passage", "type": "progene_text", "text": [ "Toluene diisocyanate ( TDI ) is a highly volatile chemical compound known to induce a wide array of diseases in workers exposed to vapors or sprays , including respiratory allergy and asthma ." ], "offsets": [ [ 0, 192 ] ] } ]
[]
[]
[]
[]
split_0_train_4753
split_0_train_4753
[ { "id": "split_0_train_4753_passage", "type": "progene_text", "text": [ "We investigated the effect of inhaled TDI on expression of CYP 1A1 , 2B1 , 2E1 , and 3A1 and of alpha - , mu - , and pi-GST in rat lung ." ], "offsets": [ [ 0, 137 ] ] } ]
[ { "id": "split_0_train_7540_entity", "type": "progene_text", "text": [ "CYP 1A1 , 2B1 , 2E1 , and 3A1" ], "offsets": [ [ 59, 88 ] ], "normalized": [] }, { "id": "split_0_train_7541_entity", "type": "progene_text", "text": [ "alpha - , mu - , and pi-GST" ], "offsets": [ [ 96, 123 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4754
split_0_train_4754
[ { "id": "split_0_train_4754_passage", "type": "progene_text", "text": [ "Animals were exposed to targeted concentrations of 0.01 , 0.1 , or 1 ppm TDI vapors or to cleaned filtered air for 8 h ." ], "offsets": [ [ 0, 120 ] ] } ]
[]
[]
[]
[]
split_0_train_4755
split_0_train_4755
[ { "id": "split_0_train_4755_passage", "type": "progene_text", "text": [ "Expression of CYP and GST was analyzed 18 24 h after the end of exposure using western blotting , northern blotting , and immunohistochemistry ." ], "offsets": [ [ 0, 144 ] ] } ]
[ { "id": "split_0_train_7542_entity", "type": "progene_text", "text": [ "CYP" ], "offsets": [ [ 14, 17 ] ], "normalized": [] }, { "id": "split_0_train_7543_entity", "type": "progene_text", "text": [ "GST" ], "offsets": [ [ 22, 25 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4756
split_0_train_4756
[ { "id": "split_0_train_4756_passage", "type": "progene_text", "text": [ "Constitutive levels of CYP 2B1 and 3A1 proteins were found in lung tissue from control rats , whereas CYP 1A1 and 2E1 proteins were not detectable ." ], "offsets": [ [ 0, 148 ] ] } ]
[ { "id": "split_0_train_7544_entity", "type": "progene_text", "text": [ "CYP 2B1 and 3A1" ], "offsets": [ [ 23, 38 ] ], "normalized": [] }, { "id": "split_0_train_7545_entity", "type": "progene_text", "text": [ "CYP 1A1 and 2E1" ], "offsets": [ [ 102, 117 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4757
split_0_train_4757
[ { "id": "split_0_train_4757_passage", "type": "progene_text", "text": [ "Animal exposure to TDI vapors neither modified CYP 3A1 protein expression , nor led to any detectable expression of CYP 1A1 or 2E1 ." ], "offsets": [ [ 0, 132 ] ] } ]
[ { "id": "split_0_train_7546_entity", "type": "progene_text", "text": [ "CYP 3A1" ], "offsets": [ [ 47, 54 ] ], "normalized": [] }, { "id": "split_0_train_7547_entity", "type": "progene_text", "text": [ "CYP 1A1 or 2E1" ], "offsets": [ [ 116, 130 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4758
split_0_train_4758
[ { "id": "split_0_train_4758_passage", "type": "progene_text", "text": [ "In contrast , exposure to 1 ppm TDI induced a 40 % reduction in CYP 2B1 protein levels ." ], "offsets": [ [ 0, 88 ] ] } ]
[ { "id": "split_0_train_7548_entity", "type": "progene_text", "text": [ "CYP 2B1" ], "offsets": [ [ 64, 71 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4759
split_0_train_4759
[ { "id": "split_0_train_4759_passage", "type": "progene_text", "text": [ "This decrease was associated with a 33 % decrease in CYP 2B1 mRNA levels ." ], "offsets": [ [ 0, 74 ] ] } ]
[ { "id": "split_0_train_7549_entity", "type": "progene_text", "text": [ "CYP 2B1" ], "offsets": [ [ 53, 60 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4760
split_0_train_4760
[ { "id": "split_0_train_4760_passage", "type": "progene_text", "text": [ "Additionally , CYP 2B1 immunolabeling localized to ciliated epithelial cells , Clara cells , and type II alveolar cells in the lung tissue of control rats was markedly decreased in animals exposed to 1 ppm TDI ." ], "offsets": [ [ 0, 211 ] ] } ]
[ { "id": "split_0_train_7550_entity", "type": "progene_text", "text": [ "CYP 2B1" ], "offsets": [ [ 15, 22 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4761
split_0_train_4761
[ { "id": "split_0_train_4761_passage", "type": "progene_text", "text": [ "Constitutive levels of alpha - , mu - , and pi - GST proteins were found in lung tissue from control rats ." ], "offsets": [ [ 0, 107 ] ] } ]
[ { "id": "split_0_train_7551_entity", "type": "progene_text", "text": [ "alpha - , mu - , and pi - GST" ], "offsets": [ [ 23, 52 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4762
split_0_train_4762
[ { "id": "split_0_train_4762_passage", "type": "progene_text", "text": [ "Exposure to TDI had no effect on lung expression of either of the GST ." ], "offsets": [ [ 0, 71 ] ] } ]
[ { "id": "split_0_train_7552_entity", "type": "progene_text", "text": [ "GST" ], "offsets": [ [ 66, 69 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4763
split_0_train_4763
[ { "id": "split_0_train_4763_passage", "type": "progene_text", "text": [ "In conclusion , this study clearly shows a selective decrease in CYP 2B1 expression by TDI vapors in rat lung ." ], "offsets": [ [ 0, 111 ] ] } ]
[ { "id": "split_0_train_7553_entity", "type": "progene_text", "text": [ "CYP 2B1" ], "offsets": [ [ 65, 72 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4764
split_0_train_4764
[ { "id": "split_0_train_4764_passage", "type": "progene_text", "text": [ "The contribution of CYP 2B1 to metabolize further xenobiotics is therefore altered ." ], "offsets": [ [ 0, 84 ] ] } ]
[ { "id": "split_0_train_7554_entity", "type": "progene_text", "text": [ "CYP 2B1" ], "offsets": [ [ 20, 27 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4765
split_0_train_4765
[ { "id": "split_0_train_4765_passage", "type": "progene_text", "text": [ "Molecular cloning and characterization of a cDNA and a gene for subtilisin - like serine proteases from rice ( Oryza sativa L. ) and Arabidopsis thaliana ." ], "offsets": [ [ 0, 155 ] ] } ]
[ { "id": "split_0_train_7555_entity", "type": "progene_text", "text": [ "subtilisin - like serine proteases" ], "offsets": [ [ 64, 98 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4766
split_0_train_4766
[ { "id": "split_0_train_4766_passage", "type": "progene_text", "text": [ "The complete nucleotide sequences of a cDNA ( RSP1 ) that encodes a subtilisin - like serine protease ( subtilase ) of rice ( Oryza sativa L. ) and a gene ( ASP48 ) for Arabidopsis subtilase were analyzed ." ], "offsets": [ [ 0, 206 ] ] } ]
[ { "id": "split_0_train_7556_entity", "type": "progene_text", "text": [ "RSP1" ], "offsets": [ [ 46, 50 ] ], "normalized": [] }, { "id": "split_0_train_7557_entity", "type": "progene_text", "text": [ "subtilisin - like serine protease" ], "offsets": [ [ 68, 101 ] ], "normalized": [] }, { "id": "split_0_train_7558_entity", "type": "progene_text", "text": [ "subtilase" ], "offsets": [ [ 104, 113 ] ], "normalized": [] }, { "id": "split_0_train_7559_entity", "type": "progene_text", "text": [ "ASP48" ], "offsets": [ [ 157, 162 ] ], "normalized": [] }, { "id": "split_0_train_7560_entity", "type": "progene_text", "text": [ "subtilase" ], "offsets": [ [ 181, 190 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4767
split_0_train_4767
[ { "id": "split_0_train_4767_passage", "type": "progene_text", "text": [ "The RSPI cDNA and ASP48 DNA encoded 736 - and 757 - residue pre - pro - polypeptides including a signal peptide with molecular masses of 78,668 Da and 79 , 414 Da , respectively ." ], "offsets": [ [ 0, 179 ] ] } ]
[ { "id": "split_0_train_7561_entity", "type": "progene_text", "text": [ "RSPI" ], "offsets": [ [ 4, 8 ] ], "normalized": [] }, { "id": "split_0_train_7562_entity", "type": "progene_text", "text": [ "ASP48" ], "offsets": [ [ 18, 23 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4768
split_0_train_4768
[ { "id": "split_0_train_4768_passage", "type": "progene_text", "text": [ "RSP1 is the first known serine protease in rice , and ASP48 is a gene for ara12 cDNA ." ], "offsets": [ [ 0, 86 ] ] } ]
[ { "id": "split_0_train_7563_entity", "type": "progene_text", "text": [ "RSP1" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "split_0_train_7564_entity", "type": "progene_text", "text": [ "serine protease" ], "offsets": [ [ 24, 39 ] ], "normalized": [] }, { "id": "split_0_train_7565_entity", "type": "progene_text", "text": [ "ASP48" ], "offsets": [ [ 54, 59 ] ], "normalized": [] }, { "id": "split_0_train_7566_entity", "type": "progene_text", "text": [ "ara12" ], "offsets": [ [ 74, 79 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4769
split_0_train_4769
[ { "id": "split_0_train_4769_passage", "type": "progene_text", "text": [ "Sequence comparison and phylogenetic analysis showed that RSP1 is distantly related to all other plant subtilases and ASP48 is closely related to a tomato subtilase , SBT1 ." ], "offsets": [ [ 0, 173 ] ] } ]
[ { "id": "split_0_train_7567_entity", "type": "progene_text", "text": [ "RSP1" ], "offsets": [ [ 58, 62 ] ], "normalized": [] }, { "id": "split_0_train_7568_entity", "type": "progene_text", "text": [ "subtilases" ], "offsets": [ [ 103, 113 ] ], "normalized": [] }, { "id": "split_0_train_7569_entity", "type": "progene_text", "text": [ "ASP48" ], "offsets": [ [ 118, 123 ] ], "normalized": [] }, { "id": "split_0_train_7570_entity", "type": "progene_text", "text": [ "subtilase" ], "offsets": [ [ 155, 164 ] ], "normalized": [] }, { "id": "split_0_train_7571_entity", "type": "progene_text", "text": [ "SBT1" ], "offsets": [ [ 167, 171 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4770
split_0_train_4770
[ { "id": "split_0_train_4770_passage", "type": "progene_text", "text": [ "The ASP48 gene was found to lack introns ." ], "offsets": [ [ 0, 42 ] ] } ]
[ { "id": "split_0_train_7572_entity", "type": "progene_text", "text": [ "ASP48" ], "offsets": [ [ 4, 9 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4771
split_0_train_4771
[ { "id": "split_0_train_4771_passage", "type": "progene_text", "text": [ "The Arabidopsis subtilase gene appears to consist of a small gene family ." ], "offsets": [ [ 0, 74 ] ] } ]
[ { "id": "split_0_train_7573_entity", "type": "progene_text", "text": [ "subtilase" ], "offsets": [ [ 16, 25 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4772
split_0_train_4772
[ { "id": "split_0_train_4772_passage", "type": "progene_text", "text": [ "The RSP1 was found to be expressed in seed and shoots of seedlings while ASP48 transcripts was found to be accumulated in immature silique and flowers , indicating that both RSP1 and ASP48 are organ - specific and may be involved in the specific proteolytic events that occur during organ development ." ], "offsets": [ [ 0, 302 ] ] } ]
[ { "id": "split_0_train_7574_entity", "type": "progene_text", "text": [ "RSP1" ], "offsets": [ [ 4, 8 ] ], "normalized": [] }, { "id": "split_0_train_7575_entity", "type": "progene_text", "text": [ "ASP48" ], "offsets": [ [ 73, 78 ] ], "normalized": [] }, { "id": "split_0_train_7576_entity", "type": "progene_text", "text": [ "RSP1" ], "offsets": [ [ 174, 178 ] ], "normalized": [] }, { "id": "split_0_train_7577_entity", "type": "progene_text", "text": [ "ASP48" ], "offsets": [ [ 183, 188 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4773
split_0_train_4773
[ { "id": "split_0_train_4773_passage", "type": "progene_text", "text": [ "Novel G proteins , Rag C and Rag D , interact with GTP - binding proteins , Rag A and Rag B ." ], "offsets": [ [ 0, 93 ] ] } ]
[ { "id": "split_0_train_7578_entity", "type": "progene_text", "text": [ "G proteins" ], "offsets": [ [ 6, 16 ] ], "normalized": [] }, { "id": "split_0_train_7579_entity", "type": "progene_text", "text": [ "Rag C" ], "offsets": [ [ 19, 24 ] ], "normalized": [] }, { "id": "split_0_train_7580_entity", "type": "progene_text", "text": [ "Rag D" ], "offsets": [ [ 29, 34 ] ], "normalized": [] }, { "id": "split_0_train_7581_entity", "type": "progene_text", "text": [ "Rag A" ], "offsets": [ [ 76, 81 ] ], "normalized": [] }, { "id": "split_0_train_7582_entity", "type": "progene_text", "text": [ "Rag B" ], "offsets": [ [ 86, 91 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4774
split_0_train_4774
[ { "id": "split_0_train_4774_passage", "type": "progene_text", "text": [ "Rag A / Gtr1p are G proteins and are known to be involved in the RCC1 - Ran pathway ." ], "offsets": [ [ 0, 85 ] ] } ]
[ { "id": "split_0_train_7583_entity", "type": "progene_text", "text": [ "Rag A" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "split_0_train_7584_entity", "type": "progene_text", "text": [ "Gtr1p" ], "offsets": [ [ 8, 13 ] ], "normalized": [] }, { "id": "split_0_train_7585_entity", "type": "progene_text", "text": [ "G proteins" ], "offsets": [ [ 18, 28 ] ], "normalized": [] }, { "id": "split_0_train_7586_entity", "type": "progene_text", "text": [ "RCC1" ], "offsets": [ [ 65, 69 ] ], "normalized": [] }, { "id": "split_0_train_7587_entity", "type": "progene_text", "text": [ "Ran" ], "offsets": [ [ 72, 75 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4775
split_0_train_4775
[ { "id": "split_0_train_4775_passage", "type": "progene_text", "text": [ "We employed the two - hybrid method using Rag A as the bait to identify proteins binding to Rag A , and we isolated two novel human G proteins , Rag C and Rag D ." ], "offsets": [ [ 0, 162 ] ] } ]
[ { "id": "split_0_train_7588_entity", "type": "progene_text", "text": [ "Rag A" ], "offsets": [ [ 42, 47 ] ], "normalized": [] }, { "id": "split_0_train_7589_entity", "type": "progene_text", "text": [ "Rag A" ], "offsets": [ [ 92, 97 ] ], "normalized": [] }, { "id": "split_0_train_7590_entity", "type": "progene_text", "text": [ "G proteins" ], "offsets": [ [ 132, 142 ] ], "normalized": [] }, { "id": "split_0_train_7591_entity", "type": "progene_text", "text": [ "Rag C" ], "offsets": [ [ 145, 150 ] ], "normalized": [] }, { "id": "split_0_train_7592_entity", "type": "progene_text", "text": [ "Rag D" ], "offsets": [ [ 155, 160 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4776
split_0_train_4776
[ { "id": "split_0_train_4776_passage", "type": "progene_text", "text": [ "Rag C demonstrates homology with Rag D ( 81.1 % identity ) and with Gtr2p of Saccharomyces cerevisiae ( 46.1 % identity ) , and it belongs to the Rag A subfamily of the Ras family ." ], "offsets": [ [ 0, 181 ] ] } ]
[ { "id": "split_0_train_7593_entity", "type": "progene_text", "text": [ "Rag C" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "split_0_train_7594_entity", "type": "progene_text", "text": [ "Rag D" ], "offsets": [ [ 33, 38 ] ], "normalized": [] }, { "id": "split_0_train_7595_entity", "type": "progene_text", "text": [ "Gtr2p" ], "offsets": [ [ 68, 73 ] ], "normalized": [] }, { "id": "split_0_train_7596_entity", "type": "progene_text", "text": [ "Rag A subfamily" ], "offsets": [ [ 146, 161 ] ], "normalized": [] }, { "id": "split_0_train_7597_entity", "type": "progene_text", "text": [ "Ras family" ], "offsets": [ [ 169, 179 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4777
split_0_train_4777
[ { "id": "split_0_train_4777_passage", "type": "progene_text", "text": [ "Rag C and Rag D contain conserved GTP - binding motifs ( PM-1 , - 2 , and -3 ) in their N - terminal regions ." ], "offsets": [ [ 0, 110 ] ] } ]
[ { "id": "split_0_train_7598_entity", "type": "progene_text", "text": [ "Rag C" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "split_0_train_7599_entity", "type": "progene_text", "text": [ "Rag D" ], "offsets": [ [ 10, 15 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4778
split_0_train_4778
[ { "id": "split_0_train_4778_passage", "type": "progene_text", "text": [ "Recombinant glutathione S-transferase fusion protein of Rag C efficiently bound to both [(3)H]GTP and [(3)H]GDP ." ], "offsets": [ [ 0, 113 ] ] } ]
[ { "id": "split_0_train_7600_entity", "type": "progene_text", "text": [ "glutathione S-transferase" ], "offsets": [ [ 12, 37 ] ], "normalized": [] }, { "id": "split_0_train_7601_entity", "type": "progene_text", "text": [ "Rag C" ], "offsets": [ [ 56, 61 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4779
split_0_train_4779
[ { "id": "split_0_train_4779_passage", "type": "progene_text", "text": [ "Rag A was associated with both Rag C and Rag D in their C - terminal regions where a potential leucine zipper motif and a coiled - coil structure were found ." ], "offsets": [ [ 0, 158 ] ] } ]
[ { "id": "split_0_train_7602_entity", "type": "progene_text", "text": [ "Rag A" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "split_0_train_7603_entity", "type": "progene_text", "text": [ "Rag C" ], "offsets": [ [ 31, 36 ] ], "normalized": [] }, { "id": "split_0_train_7604_entity", "type": "progene_text", "text": [ "Rag D" ], "offsets": [ [ 41, 46 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4780
split_0_train_4780
[ { "id": "split_0_train_4780_passage", "type": "progene_text", "text": [ "Rag C and D were associated with both the GDP and GTP forms of Rag A ." ], "offsets": [ [ 0, 70 ] ] } ]
[ { "id": "split_0_train_7605_entity", "type": "progene_text", "text": [ "Rag C and D" ], "offsets": [ [ 0, 11 ] ], "normalized": [] }, { "id": "split_0_train_7606_entity", "type": "progene_text", "text": [ "Rag A" ], "offsets": [ [ 63, 68 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4781
split_0_train_4781
[ { "id": "split_0_train_4781_passage", "type": "progene_text", "text": [ "Both Rag C and Rag D changed their subcellular localization , depending on the nucleotide - bound state of Rag A ." ], "offsets": [ [ 0, 114 ] ] } ]
[ { "id": "split_0_train_7607_entity", "type": "progene_text", "text": [ "Rag C" ], "offsets": [ [ 5, 10 ] ], "normalized": [] }, { "id": "split_0_train_7608_entity", "type": "progene_text", "text": [ "Rag D" ], "offsets": [ [ 15, 20 ] ], "normalized": [] }, { "id": "split_0_train_7609_entity", "type": "progene_text", "text": [ "Rag A" ], "offsets": [ [ 107, 112 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4782
split_0_train_4782
[ { "id": "split_0_train_4782_passage", "type": "progene_text", "text": [ "In a similar way , the disruption of S. cerevisiae GTR1 resulted in a change in the localization of Gtr2p ." ], "offsets": [ [ 0, 107 ] ] } ]
[ { "id": "split_0_train_7610_entity", "type": "progene_text", "text": [ "GTR1" ], "offsets": [ [ 51, 55 ] ], "normalized": [] }, { "id": "split_0_train_7611_entity", "type": "progene_text", "text": [ "Gtr2p" ], "offsets": [ [ 100, 105 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4783
split_0_train_4783
[ { "id": "split_0_train_4783_passage", "type": "progene_text", "text": [ "Shf , a Shb - like adapter protein , is involved in PDGF-alpha-receptor regulation of apoptosis ." ], "offsets": [ [ 0, 97 ] ] } ]
[ { "id": "split_0_train_7612_entity", "type": "progene_text", "text": [ "Shf" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "split_0_train_7613_entity", "type": "progene_text", "text": [ "Shb" ], "offsets": [ [ 8, 11 ] ], "normalized": [] }, { "id": "split_0_train_7614_entity", "type": "progene_text", "text": [ "adapter protein" ], "offsets": [ [ 19, 34 ] ], "normalized": [] }, { "id": "split_0_train_7615_entity", "type": "progene_text", "text": [ "PDGF-alpha-receptor" ], "offsets": [ [ 52, 71 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4784
split_0_train_4784
[ { "id": "split_0_train_4784_passage", "type": "progene_text", "text": [ "Recent work has implicated the importance of adapter proteins in signal transduction ." ], "offsets": [ [ 0, 86 ] ] } ]
[ { "id": "split_0_train_7616_entity", "type": "progene_text", "text": [ "adapter proteins" ], "offsets": [ [ 45, 61 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4785
split_0_train_4785
[ { "id": "split_0_train_4785_passage", "type": "progene_text", "text": [ "To identify homologues of the previously identified adapter protein Shb , database searches were performed ." ], "offsets": [ [ 0, 108 ] ] } ]
[ { "id": "split_0_train_7617_entity", "type": "progene_text", "text": [ "adapter protein" ], "offsets": [ [ 52, 67 ] ], "normalized": [] }, { "id": "split_0_train_7618_entity", "type": "progene_text", "text": [ "Shb" ], "offsets": [ [ 68, 71 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4786
split_0_train_4786
[ { "id": "split_0_train_4786_passage", "type": "progene_text", "text": [ "A Shb - like protein was found which we have named Shf ." ], "offsets": [ [ 0, 56 ] ] } ]
[ { "id": "split_0_train_7619_entity", "type": "progene_text", "text": [ "Shb" ], "offsets": [ [ 2, 5 ] ], "normalized": [] }, { "id": "split_0_train_7620_entity", "type": "progene_text", "text": [ "Shf" ], "offsets": [ [ 51, 54 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4787
split_0_train_4787
[ { "id": "split_0_train_4787_passage", "type": "progene_text", "text": [ "Shf contains an SH2 domain and four putative tyrosine phosphorylation sites and is mainly expressed in skeletal muscle , brain , liver , prostate , testis , ovary , small intestine , and colon ." ], "offsets": [ [ 0, 194 ] ] } ]
[ { "id": "split_0_train_7621_entity", "type": "progene_text", "text": [ "Shf" ], "offsets": [ [ 0, 3 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4788
split_0_train_4788
[ { "id": "split_0_train_4788_passage", "type": "progene_text", "text": [ "The SH2 domain of Shf bound to the PDGF-alpha - receptor at tyrosine - 720 , but not to the PDGF-beta-receptor in PAE cells ." ], "offsets": [ [ 0, 125 ] ] } ]
[ { "id": "split_0_train_7622_entity", "type": "progene_text", "text": [ "Shf" ], "offsets": [ [ 18, 21 ] ], "normalized": [] }, { "id": "split_0_train_7623_entity", "type": "progene_text", "text": [ "PDGF-alpha - receptor" ], "offsets": [ [ 35, 56 ] ], "normalized": [] }, { "id": "split_0_train_7624_entity", "type": "progene_text", "text": [ "PDGF-beta-receptor" ], "offsets": [ [ 92, 110 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4789
split_0_train_4789
[ { "id": "split_0_train_4789_passage", "type": "progene_text", "text": [ "Pervanadate induced tyrosine phosphorylation of Shf in NIH3T3 fibroblasts overexpressing this protein , whereas PDGF-AA alone had no detectable effect ." ], "offsets": [ [ 0, 152 ] ] } ]
[ { "id": "split_0_train_7625_entity", "type": "progene_text", "text": [ "Shf" ], "offsets": [ [ 48, 51 ] ], "normalized": [] }, { "id": "split_0_train_7626_entity", "type": "progene_text", "text": [ "PDGF-AA" ], "offsets": [ [ 112, 119 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4790
split_0_train_4790
[ { "id": "split_0_train_4790_passage", "type": "progene_text", "text": [ "NIH3T3 cells overexpressing Shf displayed significantly lower rates of apoptosis than control cells in the presence of PDGF-AA ." ], "offsets": [ [ 0, 128 ] ] } ]
[ { "id": "split_0_train_7627_entity", "type": "progene_text", "text": [ "Shf" ], "offsets": [ [ 28, 31 ] ], "normalized": [] }, { "id": "split_0_train_7628_entity", "type": "progene_text", "text": [ "PDGF-AA" ], "offsets": [ [ 119, 126 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4791
split_0_train_4791
[ { "id": "split_0_train_4791_passage", "type": "progene_text", "text": [ "Our findings suggest a role for the novel adapter Shf in PDGF - receptor signaling and regulation of apoptosis ." ], "offsets": [ [ 0, 112 ] ] } ]
[ { "id": "split_0_train_7629_entity", "type": "progene_text", "text": [ "Shf" ], "offsets": [ [ 50, 53 ] ], "normalized": [] }, { "id": "split_0_train_7630_entity", "type": "progene_text", "text": [ "PDGF - receptor" ], "offsets": [ [ 57, 72 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4792
split_0_train_4792
[ { "id": "split_0_train_4792_passage", "type": "progene_text", "text": [ "Projection structure of the monomeric porin OmpG at 6 A resolution ." ], "offsets": [ [ 0, 68 ] ] } ]
[ { "id": "split_0_train_7631_entity", "type": "progene_text", "text": [ "porin" ], "offsets": [ [ 38, 43 ] ], "normalized": [] }, { "id": "split_0_train_7632_entity", "type": "progene_text", "text": [ "OmpG" ], "offsets": [ [ 44, 48 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4793
split_0_train_4793
[ { "id": "split_0_train_4793_passage", "type": "progene_text", "text": [ "The Escherichia coli porin OmpG , which acts as an efficient unspecific channel for mono - , di - and trisaccharides , has been purified and crystallized in two dimensions ." ], "offsets": [ [ 0, 173 ] ] } ]
[ { "id": "split_0_train_7633_entity", "type": "progene_text", "text": [ "porin" ], "offsets": [ [ 21, 26 ] ], "normalized": [] }, { "id": "split_0_train_7634_entity", "type": "progene_text", "text": [ "OmpG" ], "offsets": [ [ 27, 31 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4794
split_0_train_4794
[ { "id": "split_0_train_4794_passage", "type": "progene_text", "text": [ "Projection maps of two different crystal forms of OmpG at 6 A resolution show that the protein has a beta - barrel structure characteristic for outer membrane proteins , and that it does not form trimers , unlike most other porins such as OmpF and OmpC , but appears in monomeric form ." ], "offsets": [ [ 0, 286 ] ] } ]
[ { "id": "split_0_train_7635_entity", "type": "progene_text", "text": [ "OmpG" ], "offsets": [ [ 50, 54 ] ], "normalized": [] }, { "id": "split_0_train_7636_entity", "type": "progene_text", "text": [ "porins" ], "offsets": [ [ 224, 230 ] ], "normalized": [] }, { "id": "split_0_train_7637_entity", "type": "progene_text", "text": [ "OmpF" ], "offsets": [ [ 239, 243 ] ], "normalized": [] }, { "id": "split_0_train_7638_entity", "type": "progene_text", "text": [ "OmpC" ], "offsets": [ [ 248, 252 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4795
split_0_train_4795
[ { "id": "split_0_train_4795_passage", "type": "progene_text", "text": [ "The size of the barrel is approximately 2.5 nm , indicating that OmpG may consist of 14 beta-strands ." ], "offsets": [ [ 0, 102 ] ] } ]
[ { "id": "split_0_train_7639_entity", "type": "progene_text", "text": [ "OmpG" ], "offsets": [ [ 65, 69 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4796
split_0_train_4796
[ { "id": "split_0_train_4796_passage", "type": "progene_text", "text": [ "The projection map suggests that the channel is restricted by internal loops ." ], "offsets": [ [ 0, 78 ] ] } ]
[]
[]
[]
[]
split_0_train_4797
split_0_train_4797
[ { "id": "split_0_train_4797_passage", "type": "progene_text", "text": [ "CueR ( YbbI ) of Escherichia coli is a MerR family regulator controlling expression of the copper exporter CopA ." ], "offsets": [ [ 0, 113 ] ] } ]
[ { "id": "split_0_train_7640_entity", "type": "progene_text", "text": [ "CueR" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "split_0_train_7641_entity", "type": "progene_text", "text": [ "YbbI" ], "offsets": [ [ 7, 11 ] ], "normalized": [] }, { "id": "split_0_train_7642_entity", "type": "progene_text", "text": [ "MerR family" ], "offsets": [ [ 39, 50 ] ], "normalized": [] }, { "id": "split_0_train_7643_entity", "type": "progene_text", "text": [ "CopA" ], "offsets": [ [ 107, 111 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4798
split_0_train_4798
[ { "id": "split_0_train_4798_passage", "type": "progene_text", "text": [ "We have shown that the open reading frame ybbI in the genomic sequence of Escherichia coli K-12 encodes the regulator of expression of the copper - exporting ATPase , CopA ." ], "offsets": [ [ 0, 173 ] ] } ]
[ { "id": "split_0_train_7644_entity", "type": "progene_text", "text": [ "ybbI" ], "offsets": [ [ 42, 46 ] ], "normalized": [] }, { "id": "split_0_train_7645_entity", "type": "progene_text", "text": [ "ATPase" ], "offsets": [ [ 158, 164 ] ], "normalized": [] }, { "id": "split_0_train_7646_entity", "type": "progene_text", "text": [ "CopA" ], "offsets": [ [ 167, 171 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_4799
split_0_train_4799
[ { "id": "split_0_train_4799_passage", "type": "progene_text", "text": [ "In vivo studies showed that ybbI ( designated cueR for copper export regulator gene ) was required for copper tolerance during growth , that disruption of cueR caused loss of copA expression and that copA gene expression was regulated by cueR and by copper or silver ions ." ], "offsets": [ [ 0, 273 ] ] } ]
[ { "id": "split_0_train_7647_entity", "type": "progene_text", "text": [ "ybbI" ], "offsets": [ [ 28, 32 ] ], "normalized": [] }, { "id": "split_0_train_7648_entity", "type": "progene_text", "text": [ "cueR" ], "offsets": [ [ 46, 50 ] ], "normalized": [] }, { "id": "split_0_train_7649_entity", "type": "progene_text", "text": [ "copper export regulator" ], "offsets": [ [ 55, 78 ] ], "normalized": [] }, { "id": "split_0_train_7650_entity", "type": "progene_text", "text": [ "cueR" ], "offsets": [ [ 155, 159 ] ], "normalized": [] }, { "id": "split_0_train_7651_entity", "type": "progene_text", "text": [ "copA" ], "offsets": [ [ 175, 179 ] ], "normalized": [] }, { "id": "split_0_train_7652_entity", "type": "progene_text", "text": [ "copA" ], "offsets": [ [ 200, 204 ] ], "normalized": [] }, { "id": "split_0_train_7653_entity", "type": "progene_text", "text": [ "cueR" ], "offsets": [ [ 238, 242 ] ], "normalized": [] } ]
[]
[]
[]