id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_4600
|
split_0_train_4600
|
[
{
"id": "split_0_train_4600_passage",
"type": "progene_text",
"text": [
"Pre - eclampsia ( PE ) is uniquely a disease of pregnancy and is the major cause of foetal and maternal morbidity and mortality ."
],
"offsets": [
[
0,
129
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4601
|
split_0_train_4601
|
[
{
"id": "split_0_train_4601_passage",
"type": "progene_text",
"text": [
"Epidemiological studies show that PE is highly heritable , with a high incidence in all populations ."
],
"offsets": [
[
0,
101
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4602
|
split_0_train_4602
|
[
{
"id": "split_0_train_4602_passage",
"type": "progene_text",
"text": [
"The underlying pathology indicates that absent or shallow invasion of foetal trophoblasts into maternal arteries is a feature of true PE ."
],
"offsets": [
[
0,
138
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4603
|
split_0_train_4603
|
[
{
"id": "split_0_train_4603_passage",
"type": "progene_text",
"text": [
"The objective of this study was to determine the genetic factors influencing PE ."
],
"offsets": [
[
0,
81
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4604
|
split_0_train_4604
|
[
{
"id": "split_0_train_4604_passage",
"type": "progene_text",
"text": [
"A large number of mother - father - baby trios were collected in which the first pregnancy was complicated by severe PE ."
],
"offsets": [
[
0,
121
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4605
|
split_0_train_4605
|
[
{
"id": "split_0_train_4605_passage",
"type": "progene_text",
"text": [
"After careful examination of the epidemiology and pathology of the disease , two plausible candidate genes , namely insulin - like growth factor II ( IGF - II ) and HLA - G , were analysed for association with PE ."
],
"offsets": [
[
0,
214
]
]
}
] |
[
{
"id": "split_0_train_7199_entity",
"type": "progene_text",
"text": [
"insulin - like growth factor II"
],
"offsets": [
[
116,
147
]
],
"normalized": []
},
{
"id": "split_0_train_7200_entity",
"type": "progene_text",
"text": [
"IGF - II"
],
"offsets": [
[
150,
158
]
],
"normalized": []
},
{
"id": "split_0_train_7201_entity",
"type": "progene_text",
"text": [
"HLA - G"
],
"offsets": [
[
165,
172
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4606
|
split_0_train_4606
|
[
{
"id": "split_0_train_4606_passage",
"type": "progene_text",
"text": [
"No association was found between a commonly occurring polymorphism in IGF-II and PE ."
],
"offsets": [
[
0,
85
]
]
}
] |
[
{
"id": "split_0_train_7202_entity",
"type": "progene_text",
"text": [
"IGF-II"
],
"offsets": [
[
70,
76
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4607
|
split_0_train_4607
|
[
{
"id": "split_0_train_4607_passage",
"type": "progene_text",
"text": [
"Three polymorphisms in HLA-G were analysed in the sample cohorts ."
],
"offsets": [
[
0,
66
]
]
}
] |
[
{
"id": "split_0_train_7203_entity",
"type": "progene_text",
"text": [
"HLA-G"
],
"offsets": [
[
23,
28
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4608
|
split_0_train_4608
|
[
{
"id": "split_0_train_4608_passage",
"type": "progene_text",
"text": [
"No association was found between three polymorphisms in HLA-G and PE ."
],
"offsets": [
[
0,
70
]
]
}
] |
[
{
"id": "split_0_train_7204_entity",
"type": "progene_text",
"text": [
"HLA-G"
],
"offsets": [
[
56,
61
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4609
|
split_0_train_4609
|
[
{
"id": "split_0_train_4609_passage",
"type": "progene_text",
"text": [
"However , the frequency of the HLA - G insertion / deletion polymorphism in exon 8 deviated significantly from Hardy - Weinberg expectations in PE off - spring , reflecting an excess of heterozygotes for these polymorphisms in PE offspring ."
],
"offsets": [
[
0,
241
]
]
}
] |
[
{
"id": "split_0_train_7205_entity",
"type": "progene_text",
"text": [
"HLA - G"
],
"offsets": [
[
31,
38
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4610
|
split_0_train_4610
|
[
{
"id": "split_0_train_4610_passage",
"type": "progene_text",
"text": [
"The significance of this deviation is not clear and further genetic analysis will be necessary to confirm this finding and to explore further the candidacy of HLA-G in PE ."
],
"offsets": [
[
0,
172
]
]
}
] |
[
{
"id": "split_0_train_7206_entity",
"type": "progene_text",
"text": [
"HLA-G"
],
"offsets": [
[
159,
164
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4611
|
split_0_train_4611
|
[
{
"id": "split_0_train_4611_passage",
"type": "progene_text",
"text": [
"Cell - to - cell movement of the 25K protein of potato virus X is regulated by three other viral proteins ."
],
"offsets": [
[
0,
107
]
]
}
] |
[
{
"id": "split_0_train_7207_entity",
"type": "progene_text",
"text": [
"25K protein"
],
"offsets": [
[
33,
44
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4612
|
split_0_train_4612
|
[
{
"id": "split_0_train_4612_passage",
"type": "progene_text",
"text": [
"The 25K , 12K , and 8K proteins and coat protein ( CP ) of Potato virus X ( PVX ) are required for virus cell - to - cell movement ."
],
"offsets": [
[
0,
132
]
]
}
] |
[
{
"id": "split_0_train_7208_entity",
"type": "progene_text",
"text": [
"25K , 12K , and 8K proteins"
],
"offsets": [
[
4,
31
]
],
"normalized": []
},
{
"id": "split_0_train_7209_entity",
"type": "progene_text",
"text": [
"coat protein"
],
"offsets": [
[
36,
48
]
],
"normalized": []
},
{
"id": "split_0_train_7210_entity",
"type": "progene_text",
"text": [
"CP"
],
"offsets": [
[
51,
53
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4613
|
split_0_train_4613
|
[
{
"id": "split_0_train_4613_passage",
"type": "progene_text",
"text": [
"In this study , experiments were conducted to determine whether the PVX 25K protein moves cell to cell and to explore potential interactions between the PVX 25K , 12K , and 8K proteins and CP ."
],
"offsets": [
[
0,
193
]
]
}
] |
[
{
"id": "split_0_train_7211_entity",
"type": "progene_text",
"text": [
"25K protein"
],
"offsets": [
[
72,
83
]
],
"normalized": []
},
{
"id": "split_0_train_7212_entity",
"type": "progene_text",
"text": [
"25K , 12K , and 8K proteins"
],
"offsets": [
[
157,
184
]
],
"normalized": []
},
{
"id": "split_0_train_7213_entity",
"type": "progene_text",
"text": [
"CP"
],
"offsets": [
[
189,
191
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4614
|
split_0_train_4614
|
[
{
"id": "split_0_train_4614_passage",
"type": "progene_text",
"text": [
"The PVX 25K gene was fused to the green fluorescent protein ( GFP ) gene and inserted into plasmids adjacent to the cauliflower mosaic virus 35S promoter ."
],
"offsets": [
[
0,
155
]
]
}
] |
[
{
"id": "split_0_train_7214_entity",
"type": "progene_text",
"text": [
"25K"
],
"offsets": [
[
8,
11
]
],
"normalized": []
},
{
"id": "split_0_train_7215_entity",
"type": "progene_text",
"text": [
"green fluorescent protein"
],
"offsets": [
[
34,
59
]
],
"normalized": []
},
{
"id": "split_0_train_7216_entity",
"type": "progene_text",
"text": [
"GFP"
],
"offsets": [
[
62,
65
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4615
|
split_0_train_4615
|
[
{
"id": "split_0_train_4615_passage",
"type": "progene_text",
"text": [
"These plasmids were introduced by biolistic bombardment to transgenic tobacco expressing the PVX 12K , 8K , and CP genes ."
],
"offsets": [
[
0,
122
]
]
}
] |
[
{
"id": "split_0_train_7217_entity",
"type": "progene_text",
"text": [
"12K"
],
"offsets": [
[
97,
100
]
],
"normalized": []
},
{
"id": "split_0_train_7218_entity",
"type": "progene_text",
"text": [
"8K"
],
"offsets": [
[
103,
105
]
],
"normalized": []
},
{
"id": "split_0_train_7219_entity",
"type": "progene_text",
"text": [
"CP"
],
"offsets": [
[
112,
114
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4616
|
split_0_train_4616
|
[
{
"id": "split_0_train_4616_passage",
"type": "progene_text",
"text": [
"The GFP : 25K fused proteins moved cell to cell on nontransgenic tobacco and tobacco expressing either the 12K or 8K proteins ."
],
"offsets": [
[
0,
127
]
]
}
] |
[
{
"id": "split_0_train_7220_entity",
"type": "progene_text",
"text": [
"GFP"
],
"offsets": [
[
4,
7
]
],
"normalized": []
},
{
"id": "split_0_train_7221_entity",
"type": "progene_text",
"text": [
"25K"
],
"offsets": [
[
10,
13
]
],
"normalized": []
},
{
"id": "split_0_train_7222_entity",
"type": "progene_text",
"text": [
"12K or 8K proteins"
],
"offsets": [
[
107,
125
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4617
|
split_0_train_4617
|
[
{
"id": "split_0_train_4617_passage",
"type": "progene_text",
"text": [
"However , the GFP : 25K proteins did not move on transgenic tobacco expressing the combined 12K / 8K genes or the CP gene ."
],
"offsets": [
[
0,
123
]
]
}
] |
[
{
"id": "split_0_train_7223_entity",
"type": "progene_text",
"text": [
"GFP"
],
"offsets": [
[
14,
17
]
],
"normalized": []
},
{
"id": "split_0_train_7224_entity",
"type": "progene_text",
"text": [
"25K proteins"
],
"offsets": [
[
20,
32
]
],
"normalized": []
},
{
"id": "split_0_train_7225_entity",
"type": "progene_text",
"text": [
"12K"
],
"offsets": [
[
92,
95
]
],
"normalized": []
},
{
"id": "split_0_train_7226_entity",
"type": "progene_text",
"text": [
"8K"
],
"offsets": [
[
98,
100
]
],
"normalized": []
},
{
"id": "split_0_train_7227_entity",
"type": "progene_text",
"text": [
"CP"
],
"offsets": [
[
114,
116
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4618
|
split_0_train_4618
|
[
{
"id": "split_0_train_4618_passage",
"type": "progene_text",
"text": [
"Thus , movement of the PVX 25K protein through plasmodesmata may be regulated by interactions with other PVX proteins ."
],
"offsets": [
[
0,
119
]
]
}
] |
[
{
"id": "split_0_train_7228_entity",
"type": "progene_text",
"text": [
"25K protein"
],
"offsets": [
[
27,
38
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4619
|
split_0_train_4619
|
[
{
"id": "split_0_train_4619_passage",
"type": "progene_text",
"text": [
"Inhibitory effects of IFN-gamma and acyclovir on the glioblastoma cell cycle ."
],
"offsets": [
[
0,
78
]
]
}
] |
[
{
"id": "split_0_train_7229_entity",
"type": "progene_text",
"text": [
"IFN-gamma"
],
"offsets": [
[
22,
31
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4620
|
split_0_train_4620
|
[
{
"id": "split_0_train_4620_passage",
"type": "progene_text",
"text": [
"Glioblastoma multiforme is one of the most aggressive and frequently occurring forms of brain cancer ."
],
"offsets": [
[
0,
102
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4621
|
split_0_train_4621
|
[
{
"id": "split_0_train_4621_passage",
"type": "progene_text",
"text": [
"It originates from astrocytes and is characterized by a loss of cell cycle control frequently involving mutations in tumor suppressor genes , such as p53 and p16 ."
],
"offsets": [
[
0,
163
]
]
}
] |
[
{
"id": "split_0_train_7230_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
150,
153
]
],
"normalized": []
},
{
"id": "split_0_train_7231_entity",
"type": "progene_text",
"text": [
"p16"
],
"offsets": [
[
158,
161
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4622
|
split_0_train_4622
|
[
{
"id": "split_0_train_4622_passage",
"type": "progene_text",
"text": [
"Nucleoside analogs , such as acyclovir ( ACV ) , are currently being used in the treatment of viral diseases , such as those caused by members of the herpes family ."
],
"offsets": [
[
0,
165
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4623
|
split_0_train_4623
|
[
{
"id": "split_0_train_4623_passage",
"type": "progene_text",
"text": [
"Further , ACV in combination with type I interferons ( IFN ) has been shown to be more effective at lower doses in treatment of viral diseases ."
],
"offsets": [
[
0,
144
]
]
}
] |
[
{
"id": "split_0_train_7232_entity",
"type": "progene_text",
"text": [
"type I interferons"
],
"offsets": [
[
34,
52
]
],
"normalized": []
},
{
"id": "split_0_train_7233_entity",
"type": "progene_text",
"text": [
"IFN"
],
"offsets": [
[
55,
58
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4624
|
split_0_train_4624
|
[
{
"id": "split_0_train_4624_passage",
"type": "progene_text",
"text": [
"We show here that ACV at high concentrations ( up to 500 microg / ml ) inhibited growth in tissue culture of the human glioblastoma cell lines T98G , SNB-19 , and U-373 by as much as 68.3 % while inhibiting normal human astrocytes by only 38.3 % ."
],
"offsets": [
[
0,
247
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4625
|
split_0_train_4625
|
[
{
"id": "split_0_train_4625_passage",
"type": "progene_text",
"text": [
"Related to this , the tumor cells were more than sevenfold more efficient in phosphorylation of ACV to the active phosphate form than normal human astrocytes ."
],
"offsets": [
[
0,
159
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4626
|
split_0_train_4626
|
[
{
"id": "split_0_train_4626_passage",
"type": "progene_text",
"text": [
"Analogous to treatment of virus - infected cells , suboptimal concentrations of ACV were as effective as high concentrations when used in conjunction with low concentrations of IFN-gamma in inhibition of tumor cell growth ."
],
"offsets": [
[
0,
223
]
]
}
] |
[
{
"id": "split_0_train_7234_entity",
"type": "progene_text",
"text": [
"IFN-gamma"
],
"offsets": [
[
177,
186
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4627
|
split_0_train_4627
|
[
{
"id": "split_0_train_4627_passage",
"type": "progene_text",
"text": [
"At the cellular level , ACV and IFN-gamma inhibited the cell cycle in both the G1 and S phases ."
],
"offsets": [
[
0,
96
]
]
}
] |
[
{
"id": "split_0_train_7235_entity",
"type": "progene_text",
"text": [
"IFN-gamma"
],
"offsets": [
[
32,
41
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4628
|
split_0_train_4628
|
[
{
"id": "split_0_train_4628_passage",
"type": "progene_text",
"text": [
"The cooperative effect of ACV and IFN-gamma against the glioblastomas appears to be due to direct inhibition of DNA synthesis by ACV in the S phase of the cell cycle and induction by IFN-gamma of the tumor suppressor gene p21wAF1 / CIP1 , which in turn acts at the level of proliferating cell nuclear antigen ( PCNA ) and cyclin E / cyclin - dependent kinase 2 ( Cdk2 ) binding and inhibition of function ."
],
"offsets": [
[
0,
406
]
]
}
] |
[
{
"id": "split_0_train_7236_entity",
"type": "progene_text",
"text": [
"IFN-gamma"
],
"offsets": [
[
34,
43
]
],
"normalized": []
},
{
"id": "split_0_train_7237_entity",
"type": "progene_text",
"text": [
"IFN-gamma"
],
"offsets": [
[
183,
192
]
],
"normalized": []
},
{
"id": "split_0_train_7238_entity",
"type": "progene_text",
"text": [
"p21wAF1"
],
"offsets": [
[
222,
229
]
],
"normalized": []
},
{
"id": "split_0_train_7239_entity",
"type": "progene_text",
"text": [
"CIP1"
],
"offsets": [
[
232,
236
]
],
"normalized": []
},
{
"id": "split_0_train_7240_entity",
"type": "progene_text",
"text": [
"proliferating cell nuclear antigen"
],
"offsets": [
[
274,
308
]
],
"normalized": []
},
{
"id": "split_0_train_7241_entity",
"type": "progene_text",
"text": [
"PCNA"
],
"offsets": [
[
311,
315
]
],
"normalized": []
},
{
"id": "split_0_train_7242_entity",
"type": "progene_text",
"text": [
"cyclin E"
],
"offsets": [
[
322,
330
]
],
"normalized": []
},
{
"id": "split_0_train_7243_entity",
"type": "progene_text",
"text": [
"cyclin - dependent kinase 2"
],
"offsets": [
[
333,
360
]
],
"normalized": []
},
{
"id": "split_0_train_7244_entity",
"type": "progene_text",
"text": [
"Cdk2"
],
"offsets": [
[
363,
367
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4629
|
split_0_train_4629
|
[
{
"id": "split_0_train_4629_passage",
"type": "progene_text",
"text": [
"These studies show that the combination of IFN-gamma and ACV at suboptimal concentrations elicits significant antiproliferative effects on the glioblastoma cell lines T98G , SNB-19 , and U-373 while having very little effect on normal human astrocyte cell proliferation ."
],
"offsets": [
[
0,
271
]
]
}
] |
[
{
"id": "split_0_train_7245_entity",
"type": "progene_text",
"text": [
"IFN-gamma"
],
"offsets": [
[
43,
52
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4630
|
split_0_train_4630
|
[
{
"id": "split_0_train_4630_passage",
"type": "progene_text",
"text": [
"Roles of cyclic AMP receptor protein and the carboxyl - terminal domain of the alpha subunit in transcription activation of the Escherichia coli rhaBAD operon ."
],
"offsets": [
[
0,
160
]
]
}
] |
[
{
"id": "split_0_train_7246_entity",
"type": "progene_text",
"text": [
"cyclic AMP receptor protein"
],
"offsets": [
[
9,
36
]
],
"normalized": []
},
{
"id": "split_0_train_7247_entity",
"type": "progene_text",
"text": [
"rhaBAD operon"
],
"offsets": [
[
145,
158
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4631
|
split_0_train_4631
|
[
{
"id": "split_0_train_4631_passage",
"type": "progene_text",
"text": [
"The Escherichia coli rhaBAD operon encodes the enzymes for catabolism of the sugar L-rhamnose ."
],
"offsets": [
[
0,
95
]
]
}
] |
[
{
"id": "split_0_train_7248_entity",
"type": "progene_text",
"text": [
"rhaBAD operon"
],
"offsets": [
[
21,
34
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4632
|
split_0_train_4632
|
[
{
"id": "split_0_train_4632_passage",
"type": "progene_text",
"text": [
"Full rhaBAD activation requires the AraC family activator RhaS ( bound to a site that overlaps the - 35 region of the promoter ) and the cyclic AMP receptor protein ( CRP ; bound immediately upstream of RhaS at - 92.5 ) ."
],
"offsets": [
[
0,
221
]
]
}
] |
[
{
"id": "split_0_train_7249_entity",
"type": "progene_text",
"text": [
"rhaBAD"
],
"offsets": [
[
5,
11
]
],
"normalized": []
},
{
"id": "split_0_train_7250_entity",
"type": "progene_text",
"text": [
"AraC family"
],
"offsets": [
[
36,
47
]
],
"normalized": []
},
{
"id": "split_0_train_7251_entity",
"type": "progene_text",
"text": [
"RhaS"
],
"offsets": [
[
58,
62
]
],
"normalized": []
},
{
"id": "split_0_train_7252_entity",
"type": "progene_text",
"text": [
"cyclic AMP receptor protein"
],
"offsets": [
[
137,
164
]
],
"normalized": []
},
{
"id": "split_0_train_7253_entity",
"type": "progene_text",
"text": [
"CRP"
],
"offsets": [
[
167,
170
]
],
"normalized": []
},
{
"id": "split_0_train_7254_entity",
"type": "progene_text",
"text": [
"RhaS"
],
"offsets": [
[
203,
207
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4633
|
split_0_train_4633
|
[
{
"id": "split_0_train_4633_passage",
"type": "progene_text",
"text": [
"We tested alanine substitutions in activating regions ( AR ) 1 and 2 of CRP for their effect on rhaBAD activation ."
],
"offsets": [
[
0,
115
]
]
}
] |
[
{
"id": "split_0_train_7255_entity",
"type": "progene_text",
"text": [
"CRP"
],
"offsets": [
[
72,
75
]
],
"normalized": []
},
{
"id": "split_0_train_7256_entity",
"type": "progene_text",
"text": [
"rhaBAD"
],
"offsets": [
[
96,
102
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4634
|
split_0_train_4634
|
[
{
"id": "split_0_train_4634_passage",
"type": "progene_text",
"text": [
"Some , but not all , of the substitutions in both AR1 and AR2 resulted in approximately twofold defects in expression from rhaBAD promoter fusions ."
],
"offsets": [
[
0,
148
]
]
}
] |
[
{
"id": "split_0_train_7257_entity",
"type": "progene_text",
"text": [
"rhaBAD"
],
"offsets": [
[
123,
129
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4635
|
split_0_train_4635
|
[
{
"id": "split_0_train_4635_passage",
"type": "progene_text",
"text": [
"We also expressed a derivative of the alpha subunit of RNA polymerase deleted for the entire C - terminal domain ( alpha-Delta235 ) and assayed expression from rhaBAD promoter fusions ."
],
"offsets": [
[
0,
185
]
]
}
] |
[
{
"id": "split_0_train_7258_entity",
"type": "progene_text",
"text": [
"alpha subunit of RNA polymerase"
],
"offsets": [
[
38,
69
]
],
"normalized": []
},
{
"id": "split_0_train_7259_entity",
"type": "progene_text",
"text": [
"rhaBAD"
],
"offsets": [
[
160,
166
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4636
|
split_0_train_4636
|
[
{
"id": "split_0_train_4636_passage",
"type": "progene_text",
"text": [
"The greatest defect ( 54 - fold ) occurred at a truncated promoter where RhaS was the only activator , while the defect at the full - length promoter ( RhaS plus CRP ) was smaller ( 13 - fold ) ."
],
"offsets": [
[
0,
195
]
]
}
] |
[
{
"id": "split_0_train_7260_entity",
"type": "progene_text",
"text": [
"RhaS"
],
"offsets": [
[
73,
77
]
],
"normalized": []
},
{
"id": "split_0_train_7261_entity",
"type": "progene_text",
"text": [
"RhaS"
],
"offsets": [
[
152,
156
]
],
"normalized": []
},
{
"id": "split_0_train_7262_entity",
"type": "progene_text",
"text": [
"CRP"
],
"offsets": [
[
162,
165
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4637
|
split_0_train_4637
|
[
{
"id": "split_0_train_4637_passage",
"type": "progene_text",
"text": [
"Analysis of a plasmid library expressing alanine substitutions at every residue in the carboxyl - terminal domain of the alpha subunit ( alpha-CTD ) identified 15 residues ( mostly in the DNA - binding determinant ) that were important at both the full - length and truncated promoters ."
],
"offsets": [
[
0,
287
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4638
|
split_0_train_4638
|
[
{
"id": "split_0_train_4638_passage",
"type": "progene_text",
"text": [
"Only one substitution was defective at the full - length but not the truncated promoter , and this residue was located in the DNA - binding determinant ."
],
"offsets": [
[
0,
153
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4639
|
split_0_train_4639
|
[
{
"id": "split_0_train_4639_passage",
"type": "progene_text",
"text": [
"Six substitutions were defective only at the promoter activated by RhaS alone , and these may define a protein - contacting determinant on alpha-CTD ."
],
"offsets": [
[
0,
150
]
]
}
] |
[
{
"id": "split_0_train_7263_entity",
"type": "progene_text",
"text": [
"RhaS"
],
"offsets": [
[
67,
71
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4640
|
split_0_train_4640
|
[
{
"id": "split_0_train_4640_passage",
"type": "progene_text",
"text": [
"Overall , our results suggest that CRP interaction with alpha-CTD may not be required for rhaBAD activation ; however , alpha-CTD does contribute to full activation , probably through interactions with DNA and possibly RhaS ."
],
"offsets": [
[
0,
225
]
]
}
] |
[
{
"id": "split_0_train_7264_entity",
"type": "progene_text",
"text": [
"CRP"
],
"offsets": [
[
35,
38
]
],
"normalized": []
},
{
"id": "split_0_train_7265_entity",
"type": "progene_text",
"text": [
"rhaBAD"
],
"offsets": [
[
90,
96
]
],
"normalized": []
},
{
"id": "split_0_train_7266_entity",
"type": "progene_text",
"text": [
"RhaS"
],
"offsets": [
[
219,
223
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4641
|
split_0_train_4641
|
[
{
"id": "split_0_train_4641_passage",
"type": "progene_text",
"text": [
"Src homology domain 2 - containing tyrosine phosphatase 2 associates with intercellular adhesion molecule 1 to regulate cell survival ."
],
"offsets": [
[
0,
135
]
]
}
] |
[
{
"id": "split_0_train_7267_entity",
"type": "progene_text",
"text": [
"Src homology domain 2 - containing tyrosine phosphatase 2"
],
"offsets": [
[
0,
57
]
],
"normalized": []
},
{
"id": "split_0_train_7268_entity",
"type": "progene_text",
"text": [
"intercellular adhesion molecule 1"
],
"offsets": [
[
74,
107
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4642
|
split_0_train_4642
|
[
{
"id": "split_0_train_4642_passage",
"type": "progene_text",
"text": [
"Intercellular adhesion molecule-1 ( ICAM-1 ) binds to the plasma protein fibrinogen ( Fg ) to mediate leukocyte / endothelial cell interactions ."
],
"offsets": [
[
0,
145
]
]
}
] |
[
{
"id": "split_0_train_7269_entity",
"type": "progene_text",
"text": [
"Intercellular adhesion molecule-1"
],
"offsets": [
[
0,
33
]
],
"normalized": []
},
{
"id": "split_0_train_7270_entity",
"type": "progene_text",
"text": [
"ICAM-1"
],
"offsets": [
[
36,
42
]
],
"normalized": []
},
{
"id": "split_0_train_7271_entity",
"type": "progene_text",
"text": [
"fibrinogen"
],
"offsets": [
[
73,
83
]
],
"normalized": []
},
{
"id": "split_0_train_7272_entity",
"type": "progene_text",
"text": [
"Fg"
],
"offsets": [
[
86,
88
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4643
|
split_0_train_4643
|
[
{
"id": "split_0_train_4643_passage",
"type": "progene_text",
"text": [
"In our studies , the ligation of Fg to ICAM-1 on tumor necrosis factor-alpha - stimulated endothelial cells resulted in the tyrosine phosphorylation of Src homology domain 2 ( SH2 ) - containing phosphatase-2 ( SHP-2 ) ."
],
"offsets": [
[
0,
220
]
]
}
] |
[
{
"id": "split_0_train_7273_entity",
"type": "progene_text",
"text": [
"Fg"
],
"offsets": [
[
33,
35
]
],
"normalized": []
},
{
"id": "split_0_train_7274_entity",
"type": "progene_text",
"text": [
"ICAM-1"
],
"offsets": [
[
39,
45
]
],
"normalized": []
},
{
"id": "split_0_train_7275_entity",
"type": "progene_text",
"text": [
"tumor necrosis factor-alpha"
],
"offsets": [
[
49,
76
]
],
"normalized": []
},
{
"id": "split_0_train_7276_entity",
"type": "progene_text",
"text": [
"Src homology domain 2 ( SH2 ) - containing phosphatase-2"
],
"offsets": [
[
152,
208
]
],
"normalized": []
},
{
"id": "split_0_train_7277_entity",
"type": "progene_text",
"text": [
"SHP-2"
],
"offsets": [
[
211,
216
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4644
|
split_0_train_4644
|
[
{
"id": "split_0_train_4644_passage",
"type": "progene_text",
"text": [
"The ICAM-1 cytoplasmic sequence IKKYRLQ conforms poorly to the concensus immunoreceptor tyrosine - based inhibition motifs found in receptors that bind SHP-2 ."
],
"offsets": [
[
0,
159
]
]
}
] |
[
{
"id": "split_0_train_7278_entity",
"type": "progene_text",
"text": [
"ICAM-1"
],
"offsets": [
[
4,
10
]
],
"normalized": []
},
{
"id": "split_0_train_7279_entity",
"type": "progene_text",
"text": [
"SHP-2"
],
"offsets": [
[
152,
157
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4645
|
split_0_train_4645
|
[
{
"id": "split_0_train_4645_passage",
"type": "progene_text",
"text": [
"Nevertheless , the tyrosine phosphorylated sequence ( IKKpYRLQ ) bound specifically to the SH2 domain proximal to the NH(2) - terminal of SHP-2 ( SHP-2 - N ) but not to the SH2 domain proximal on the COOH - terminal side ( SHP-2 - C ) ."
],
"offsets": [
[
0,
236
]
]
}
] |
[
{
"id": "split_0_train_7280_entity",
"type": "progene_text",
"text": [
"SHP-2"
],
"offsets": [
[
138,
143
]
],
"normalized": []
},
{
"id": "split_0_train_7281_entity",
"type": "progene_text",
"text": [
"SHP-2"
],
"offsets": [
[
146,
151
]
],
"normalized": []
},
{
"id": "split_0_train_7282_entity",
"type": "progene_text",
"text": [
"SHP-2"
],
"offsets": [
[
223,
228
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4646
|
split_0_train_4646
|
[
{
"id": "split_0_train_4646_passage",
"type": "progene_text",
"text": [
"Phosphorylated ICAM-1 bound SHP-2 - N ."
],
"offsets": [
[
0,
39
]
]
}
] |
[
{
"id": "split_0_train_7283_entity",
"type": "progene_text",
"text": [
"ICAM-1"
],
"offsets": [
[
15,
21
]
],
"normalized": []
},
{
"id": "split_0_train_7284_entity",
"type": "progene_text",
"text": [
"SHP-2"
],
"offsets": [
[
28,
33
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4647
|
split_0_train_4647
|
[
{
"id": "split_0_train_4647_passage",
"type": "progene_text",
"text": [
"In immunoprecipitation experiments , SHP-2 associated with phosphorylated ICAM-1 ."
],
"offsets": [
[
0,
82
]
]
}
] |
[
{
"id": "split_0_train_7285_entity",
"type": "progene_text",
"text": [
"SHP-2"
],
"offsets": [
[
37,
42
]
],
"normalized": []
},
{
"id": "split_0_train_7286_entity",
"type": "progene_text",
"text": [
"ICAM-1"
],
"offsets": [
[
74,
80
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4648
|
split_0_train_4648
|
[
{
"id": "split_0_train_4648_passage",
"type": "progene_text",
"text": [
"Cells expressing truncated ICAM-1 that lacked the cytoplasmic sequence ( ICAM-1 ( TR ) ) failed to associate with SHP-2 ."
],
"offsets": [
[
0,
121
]
]
}
] |
[
{
"id": "split_0_train_7287_entity",
"type": "progene_text",
"text": [
"ICAM-1"
],
"offsets": [
[
27,
33
]
],
"normalized": []
},
{
"id": "split_0_train_7288_entity",
"type": "progene_text",
"text": [
"ICAM-1"
],
"offsets": [
[
73,
79
]
],
"normalized": []
},
{
"id": "split_0_train_7289_entity",
"type": "progene_text",
"text": [
"SHP-2"
],
"offsets": [
[
114,
119
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4649
|
split_0_train_4649
|
[
{
"id": "split_0_train_4649_passage",
"type": "progene_text",
"text": [
"ICAM-1 containing the tyrosine to alanine substitution at position 485 ( ICAM-1 ( Y485A ) ) associated weakly with SHP-2 ."
],
"offsets": [
[
0,
122
]
]
}
] |
[
{
"id": "split_0_train_7290_entity",
"type": "progene_text",
"text": [
"ICAM-1"
],
"offsets": [
[
0,
6
]
],
"normalized": []
},
{
"id": "split_0_train_7291_entity",
"type": "progene_text",
"text": [
"ICAM-1"
],
"offsets": [
[
73,
79
]
],
"normalized": []
},
{
"id": "split_0_train_7292_entity",
"type": "progene_text",
"text": [
"SHP-2"
],
"offsets": [
[
115,
120
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4650
|
split_0_train_4650
|
[
{
"id": "split_0_train_4650_passage",
"type": "progene_text",
"text": [
"Cells expressing ICAM-1 ( TR ) and ICAM-1 ( Y485A ) underwent apoptosis upon adhesion to Fg , whereas the wild type ICAM-1 maintained cell survival ."
],
"offsets": [
[
0,
149
]
]
}
] |
[
{
"id": "split_0_train_7293_entity",
"type": "progene_text",
"text": [
"ICAM-1"
],
"offsets": [
[
17,
23
]
],
"normalized": []
},
{
"id": "split_0_train_7294_entity",
"type": "progene_text",
"text": [
"ICAM-1"
],
"offsets": [
[
35,
41
]
],
"normalized": []
},
{
"id": "split_0_train_7295_entity",
"type": "progene_text",
"text": [
"Fg"
],
"offsets": [
[
89,
91
]
],
"normalized": []
},
{
"id": "split_0_train_7296_entity",
"type": "progene_text",
"text": [
"ICAM-1"
],
"offsets": [
[
116,
122
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4651
|
split_0_train_4651
|
[
{
"id": "split_0_train_4651_passage",
"type": "progene_text",
"text": [
"These results indicate that ICAM-1 interactions with SHP-2 allow better cellular survival mediated through Fg - ICAM-1 ligation ."
],
"offsets": [
[
0,
129
]
]
}
] |
[
{
"id": "split_0_train_7297_entity",
"type": "progene_text",
"text": [
"ICAM-1"
],
"offsets": [
[
28,
34
]
],
"normalized": []
},
{
"id": "split_0_train_7298_entity",
"type": "progene_text",
"text": [
"SHP-2"
],
"offsets": [
[
53,
58
]
],
"normalized": []
},
{
"id": "split_0_train_7299_entity",
"type": "progene_text",
"text": [
"Fg"
],
"offsets": [
[
107,
109
]
],
"normalized": []
},
{
"id": "split_0_train_7300_entity",
"type": "progene_text",
"text": [
"ICAM-1"
],
"offsets": [
[
112,
118
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4652
|
split_0_train_4652
|
[
{
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[] |
[] |
split_0_train_4653
|
split_0_train_4653
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] |
[] |
[] |
[] |
split_0_train_4654
|
split_0_train_4654
|
[
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"The 24 - OHase enzyme can also act on the 25-hydroxyvitamin D substrate to generate 24,25-dihydroxyvitamin D , a metabolite whose physiological importance remains unclear ."
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"24 - OHase"
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4,
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] |
[] |
[] |
[] |
split_0_train_4655
|
split_0_train_4655
|
[
{
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"24-OHase"
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65,
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[] |
[] |
[] |
split_0_train_4656
|
split_0_train_4656
|
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"Surprisingly , complete absence of 24 - OHase activity during development leads to impaired intramembranous bone mineralization ."
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}
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35,
45
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}
] |
[] |
[] |
[] |
split_0_train_4657
|
split_0_train_4657
|
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"text": [
"This phenotype was rescued by crossing the 24-OHase mutant mice to mice harboring a targeted mutation in the vitamin D receptor gene , confirming that the elevated 1,25(OH)2D levels , acting through the vitamin D receptor , were responsible for the observed accumulation of osteoid ."
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283
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}
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{
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"text": [
"vitamin D receptor"
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203,
221
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}
] |
[] |
[] |
[] |
split_0_train_4658
|
split_0_train_4658
|
[
{
"id": "split_0_train_4658_passage",
"type": "progene_text",
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"Our results confirm the physiological importance of the 24 - OHase enzyme for maintaining vitamin D homeostasis , and they reveal that 24,25-dihydroxyvitamin D is a dispensable metabolite during bone development ."
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[
0,
213
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}
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{
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"text": [
"24 - OHase"
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56,
66
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}
] |
[] |
[] |
[] |
split_0_train_4659
|
split_0_train_4659
|
[
{
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"type": "progene_text",
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"Regulation of interleukin 6 production in a human gastric epithelial cell line MKN-28 ."
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0,
87
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}
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[
{
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"text": [
"interleukin 6"
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[
14,
27
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}
] |
[] |
[] |
[] |
split_0_train_4660
|
split_0_train_4660
|
[
{
"id": "split_0_train_4660_passage",
"type": "progene_text",
"text": [
"Interleukin ( IL-) 6 is closely related to gastrointestinal diseases ."
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[
0,
70
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}
] |
[
{
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"text": [
"Interleukin ( IL-) 6"
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[
0,
20
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}
] |
[] |
[] |
[] |
split_0_train_4661
|
split_0_train_4661
|
[
{
"id": "split_0_train_4661_passage",
"type": "progene_text",
"text": [
"The question of whether gastric epithelial cell contributes to IL-6 production remains undefined ."
],
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[
0,
98
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]
}
] |
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{
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"type": "progene_text",
"text": [
"IL-6"
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[
63,
67
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}
] |
[] |
[] |
[] |
split_0_train_4662
|
split_0_train_4662
|
[
{
"id": "split_0_train_4662_passage",
"type": "progene_text",
"text": [
"We aim to evaluate the regulatory pathway of IL-6 expression in gastric epithelial cells , by using different inflammatory cytokines , endotoxin , or protein kinase modulators ."
],
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0,
177
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]
}
] |
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"text": [
"protein kinase"
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[
150,
164
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}
] |
[] |
[] |
[] |
split_0_train_4663
|
split_0_train_4663
|
[
{
"id": "split_0_train_4663_passage",
"type": "progene_text",
"text": [
"IL-6 was measured by ELISA ."
],
"offsets": [
[
0,
28
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]
}
] |
[
{
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"type": "progene_text",
"text": [
"IL-6"
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[
0,
4
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],
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}
] |
[] |
[] |
[] |
split_0_train_4664
|
split_0_train_4664
|
[
{
"id": "split_0_train_4664_passage",
"type": "progene_text",
"text": [
"Phorbol-12-myristate-13-acetate ( PMA ) , calcium ionophore A23187 , TNF-alpha , IL-1beta , oncostatin M ( OSM ) but not lipopolysaccharide stimulated IL-6 production from gastric epithelial cell line MKN-28 ."
],
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0,
209
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]
}
] |
[
{
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107,
110
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"type": "progene_text",
"text": [
"IL-6"
],
"offsets": [
[
151,
155
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4665
|
split_0_train_4665
|
[
{
"id": "split_0_train_4665_passage",
"type": "progene_text",
"text": [
"Blocking protein tyrosine kinase ( PTK ) activation by herbimycin A or genistein , or blocking NF-kappaB activation by pyrrolidinedithiocarbamate , reduced the IL-6 expression induced by TNF - alpha , IL-1beta and OSM ."
],
"offsets": [
[
0,
219
]
]
}
] |
[
{
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"text": [
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{
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35,
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160,
164
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{
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187,
198
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{
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201,
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{
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"type": "progene_text",
"text": [
"OSM"
],
"offsets": [
[
214,
217
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4666
|
split_0_train_4666
|
[
{
"id": "split_0_train_4666_passage",
"type": "progene_text",
"text": [
"Dexamethasone mimicked this effect ."
],
"offsets": [
[
0,
36
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4667
|
split_0_train_4667
|
[
{
"id": "split_0_train_4667_passage",
"type": "progene_text",
"text": [
"Protein kinase ( PK ) C inhibitor only reduced the PMA and OSM induced IL-6 production ."
],
"offsets": [
[
0,
88
]
]
}
] |
[
{
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"text": [
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23
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{
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62
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{
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"type": "progene_text",
"text": [
"IL-6"
],
"offsets": [
[
71,
75
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4668
|
split_0_train_4668
|
[
{
"id": "split_0_train_4668_passage",
"type": "progene_text",
"text": [
"Both inhibitors and activators for PKA and G-protein as well as IL-10 had no effects on IL-6 expression ."
],
"offsets": [
[
0,
105
]
]
}
] |
[
{
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"type": "progene_text",
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35,
38
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{
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52
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{
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"type": "progene_text",
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64,
69
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{
"id": "split_0_train_7336_entity",
"type": "progene_text",
"text": [
"IL-6"
],
"offsets": [
[
88,
92
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4669
|
split_0_train_4669
|
[
{
"id": "split_0_train_4669_passage",
"type": "progene_text",
"text": [
"These results indicate that inflammatory cytokines are crucial for IL-6 regulation in gastric epithelial cells ."
],
"offsets": [
[
0,
112
]
]
}
] |
[
{
"id": "split_0_train_7337_entity",
"type": "progene_text",
"text": [
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41,
50
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{
"id": "split_0_train_7338_entity",
"type": "progene_text",
"text": [
"IL-6"
],
"offsets": [
[
67,
71
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4670
|
split_0_train_4670
|
[
{
"id": "split_0_train_4670_passage",
"type": "progene_text",
"text": [
"The IL-6 signal pathway is mediated through PTK , NF-kappaB , and also involve PKC , intracellular calcium and sensitive to dexamethasone , but is not related to PKA , G-protein and IL-10 ."
],
"offsets": [
[
0,
189
]
]
}
] |
[
{
"id": "split_0_train_7339_entity",
"type": "progene_text",
"text": [
"IL-6"
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4,
8
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{
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"text": [
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44,
47
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},
{
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"type": "progene_text",
"text": [
"NF-kappaB"
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[
50,
59
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{
"id": "split_0_train_7342_entity",
"type": "progene_text",
"text": [
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79,
82
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{
"id": "split_0_train_7343_entity",
"type": "progene_text",
"text": [
"PKA"
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[
162,
165
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],
"normalized": []
},
{
"id": "split_0_train_7344_entity",
"type": "progene_text",
"text": [
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"offsets": [
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168,
177
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{
"id": "split_0_train_7345_entity",
"type": "progene_text",
"text": [
"IL-10"
],
"offsets": [
[
182,
187
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4671
|
split_0_train_4671
|
[
{
"id": "split_0_train_4671_passage",
"type": "progene_text",
"text": [
"BCoR , a novel corepressor involved in BCL-6 repression ."
],
"offsets": [
[
0,
57
]
]
}
] |
[
{
"id": "split_0_train_7346_entity",
"type": "progene_text",
"text": [
"BCoR"
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"offsets": [
[
0,
4
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},
{
"id": "split_0_train_7347_entity",
"type": "progene_text",
"text": [
"BCL-6"
],
"offsets": [
[
39,
44
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4672
|
split_0_train_4672
|
[
{
"id": "split_0_train_4672_passage",
"type": "progene_text",
"text": [
"BCL-6 encodes a POZ / zinc finger transcriptional repressor that is required for germinal center formation and may influence apoptosis ."
],
"offsets": [
[
0,
136
]
]
}
] |
[
{
"id": "split_0_train_7348_entity",
"type": "progene_text",
"text": [
"BCL-6"
],
"offsets": [
[
0,
5
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4673
|
split_0_train_4673
|
[
{
"id": "split_0_train_4673_passage",
"type": "progene_text",
"text": [
"Aberrant expression of BCL-6 due to chromosomal translocations is implicated in certain subtypes of non - Hodgkin 's lymphoma ."
],
"offsets": [
[
0,
127
]
]
}
] |
[
{
"id": "split_0_train_7349_entity",
"type": "progene_text",
"text": [
"BCL-6"
],
"offsets": [
[
23,
28
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4674
|
split_0_train_4674
|
[
{
"id": "split_0_train_4674_passage",
"type": "progene_text",
"text": [
"The POZ domains of BCL-6 and several other POZ proteins interact with corepressors N-CoR and SMRT ."
],
"offsets": [
[
0,
99
]
]
}
] |
[
{
"id": "split_0_train_7350_entity",
"type": "progene_text",
"text": [
"BCL-6"
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"offsets": [
[
19,
24
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],
"normalized": []
},
{
"id": "split_0_train_7351_entity",
"type": "progene_text",
"text": [
"N-CoR"
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"offsets": [
[
83,
88
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],
"normalized": []
},
{
"id": "split_0_train_7352_entity",
"type": "progene_text",
"text": [
"SMRT"
],
"offsets": [
[
93,
97
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4675
|
split_0_train_4675
|
[
{
"id": "split_0_train_4675_passage",
"type": "progene_text",
"text": [
"Here we identify and characterize a novel corepressor BCoR ( BCL-6 interacting corepressor ) , which is expressed ubiquitously in human tissues ."
],
"offsets": [
[
0,
145
]
]
}
] |
[
{
"id": "split_0_train_7353_entity",
"type": "progene_text",
"text": [
"BCoR"
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"offsets": [
[
54,
58
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],
"normalized": []
},
{
"id": "split_0_train_7354_entity",
"type": "progene_text",
"text": [
"BCL-6 interacting corepressor"
],
"offsets": [
[
61,
90
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4676
|
split_0_train_4676
|
[
{
"id": "split_0_train_4676_passage",
"type": "progene_text",
"text": [
"BCoR can function as a corepressor when tethered to DNA and , when overexpressed , can potentiate BCL-6 repression ."
],
"offsets": [
[
0,
116
]
]
}
] |
[
{
"id": "split_0_train_7355_entity",
"type": "progene_text",
"text": [
"BCoR"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_7356_entity",
"type": "progene_text",
"text": [
"BCL-6"
],
"offsets": [
[
98,
103
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4677
|
split_0_train_4677
|
[
{
"id": "split_0_train_4677_passage",
"type": "progene_text",
"text": [
"Specific class I and II histone deacetylases ( HDACs ) interact in vivo with BCoR , suggesting that BCoR may functionally link these two classes of HDACs ."
],
"offsets": [
[
0,
155
]
]
}
] |
[
{
"id": "split_0_train_7357_entity",
"type": "progene_text",
"text": [
"histone deacetylases"
],
"offsets": [
[
24,
44
]
],
"normalized": []
},
{
"id": "split_0_train_7358_entity",
"type": "progene_text",
"text": [
"HDACs"
],
"offsets": [
[
47,
52
]
],
"normalized": []
},
{
"id": "split_0_train_7359_entity",
"type": "progene_text",
"text": [
"BCoR"
],
"offsets": [
[
77,
81
]
],
"normalized": []
},
{
"id": "split_0_train_7360_entity",
"type": "progene_text",
"text": [
"BCoR"
],
"offsets": [
[
100,
104
]
],
"normalized": []
},
{
"id": "split_0_train_7361_entity",
"type": "progene_text",
"text": [
"HDACs"
],
"offsets": [
[
148,
153
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4678
|
split_0_train_4678
|
[
{
"id": "split_0_train_4678_passage",
"type": "progene_text",
"text": [
"Strikingly , BCoR interacts selectively with the POZ domain of BCL-6 but not with eight other POZ proteins tested , including PLZF ."
],
"offsets": [
[
0,
132
]
]
}
] |
[
{
"id": "split_0_train_7362_entity",
"type": "progene_text",
"text": [
"BCoR"
],
"offsets": [
[
13,
17
]
],
"normalized": []
},
{
"id": "split_0_train_7363_entity",
"type": "progene_text",
"text": [
"BCL-6"
],
"offsets": [
[
63,
68
]
],
"normalized": []
},
{
"id": "split_0_train_7364_entity",
"type": "progene_text",
"text": [
"PLZF"
],
"offsets": [
[
126,
130
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4679
|
split_0_train_4679
|
[
{
"id": "split_0_train_4679_passage",
"type": "progene_text",
"text": [
"Additionally , interactions between the BCL-6 POZ domain and SMRT , N-CoR , and BCoR are mutually exclusive ."
],
"offsets": [
[
0,
109
]
]
}
] |
[
{
"id": "split_0_train_7365_entity",
"type": "progene_text",
"text": [
"BCL-6"
],
"offsets": [
[
40,
45
]
],
"normalized": []
},
{
"id": "split_0_train_7366_entity",
"type": "progene_text",
"text": [
"SMRT"
],
"offsets": [
[
61,
65
]
],
"normalized": []
},
{
"id": "split_0_train_7367_entity",
"type": "progene_text",
"text": [
"N-CoR"
],
"offsets": [
[
68,
73
]
],
"normalized": []
},
{
"id": "split_0_train_7368_entity",
"type": "progene_text",
"text": [
"BCoR"
],
"offsets": [
[
80,
84
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4680
|
split_0_train_4680
|
[
{
"id": "split_0_train_4680_passage",
"type": "progene_text",
"text": [
"The specificity of the BCL-6 / BCoR interaction suggests that BCoR may have a role in BCL-6 - associated lymphomas ."
],
"offsets": [
[
0,
116
]
]
}
] |
[
{
"id": "split_0_train_7369_entity",
"type": "progene_text",
"text": [
"BCL-6"
],
"offsets": [
[
23,
28
]
],
"normalized": []
},
{
"id": "split_0_train_7370_entity",
"type": "progene_text",
"text": [
"BCoR"
],
"offsets": [
[
31,
35
]
],
"normalized": []
},
{
"id": "split_0_train_7371_entity",
"type": "progene_text",
"text": [
"BCoR"
],
"offsets": [
[
62,
66
]
],
"normalized": []
},
{
"id": "split_0_train_7372_entity",
"type": "progene_text",
"text": [
"BCL-6"
],
"offsets": [
[
86,
91
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4681
|
split_0_train_4681
|
[
{
"id": "split_0_train_4681_passage",
"type": "progene_text",
"text": [
"Regulation of expression of the yiaKLMNOPQRS operon for carbohydrate utilization in Escherichia coli : involvement of the main transcriptional factors ."
],
"offsets": [
[
0,
152
]
]
}
] |
[
{
"id": "split_0_train_7373_entity",
"type": "progene_text",
"text": [
"yiaKLMNOPQRS operon"
],
"offsets": [
[
32,
51
]
],
"normalized": []
},
{
"id": "split_0_train_7374_entity",
"type": "progene_text",
"text": [
"transcriptional factors"
],
"offsets": [
[
127,
150
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4682
|
split_0_train_4682
|
[
{
"id": "split_0_train_4682_passage",
"type": "progene_text",
"text": [
"The yiaKLMNOPQRS ( yiaK-S ) gene cluster of Escherichia coli is believed to be involved in the utilization of a hitherto unknown carbohydrate which generates the intermediate L-xylulose ."
],
"offsets": [
[
0,
187
]
]
}
] |
[
{
"id": "split_0_train_7375_entity",
"type": "progene_text",
"text": [
"yiaKLMNOPQRS"
],
"offsets": [
[
4,
16
]
],
"normalized": []
},
{
"id": "split_0_train_7376_entity",
"type": "progene_text",
"text": [
"yiaK-S"
],
"offsets": [
[
19,
25
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4683
|
split_0_train_4683
|
[
{
"id": "split_0_train_4683_passage",
"type": "progene_text",
"text": [
"Transcription of yiaK-S as a single message from the unique promoter found upstream of yiaK is proven in this study ."
],
"offsets": [
[
0,
117
]
]
}
] |
[
{
"id": "split_0_train_7377_entity",
"type": "progene_text",
"text": [
"yiaK-S"
],
"offsets": [
[
17,
23
]
],
"normalized": []
},
{
"id": "split_0_train_7378_entity",
"type": "progene_text",
"text": [
"yiaK"
],
"offsets": [
[
87,
91
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4684
|
split_0_train_4684
|
[
{
"id": "split_0_train_4684_passage",
"type": "progene_text",
"text": [
"The 5' end has been located at 60 bp upstream from the ATG ."
],
"offsets": [
[
0,
60
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4685
|
split_0_train_4685
|
[
{
"id": "split_0_train_4685_passage",
"type": "progene_text",
"text": [
"Expression of the yiaK-S operon is controlled in the wild - type strain by a repressor encoded by yiaJ ."
],
"offsets": [
[
0,
104
]
]
}
] |
[
{
"id": "split_0_train_7379_entity",
"type": "progene_text",
"text": [
"yiaK-S operon"
],
"offsets": [
[
18,
31
]
],
"normalized": []
},
{
"id": "split_0_train_7380_entity",
"type": "progene_text",
"text": [
"yiaJ"
],
"offsets": [
[
98,
102
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4686
|
split_0_train_4686
|
[
{
"id": "split_0_train_4686_passage",
"type": "progene_text",
"text": [
"No inducer molecule of the yiaK-S operon has been identified among over 80 carbohydrate or derivative compounds tested , the system being expressed only in a mutant strain lacking the YiaJ repressor ."
],
"offsets": [
[
0,
200
]
]
}
] |
[
{
"id": "split_0_train_7381_entity",
"type": "progene_text",
"text": [
"yiaK-S operon"
],
"offsets": [
[
27,
40
]
],
"normalized": []
},
{
"id": "split_0_train_7382_entity",
"type": "progene_text",
"text": [
"YiaJ"
],
"offsets": [
[
184,
188
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4687
|
split_0_train_4687
|
[
{
"id": "split_0_train_4687_passage",
"type": "progene_text",
"text": [
"The lacZ transcriptional fusions in the genetic background of the mutant strain revealed that yiaK-S is modulated by the integration host factor and by the cyclic AMP ( cAMP ) - cAMP receptor protein ( Crp ) activator complex ."
],
"offsets": [
[
0,
227
]
]
}
] |
[
{
"id": "split_0_train_7383_entity",
"type": "progene_text",
"text": [
"lacZ"
],
"offsets": [
[
4,
8
]
],
"normalized": []
},
{
"id": "split_0_train_7384_entity",
"type": "progene_text",
"text": [
"yiaK-S"
],
"offsets": [
[
94,
100
]
],
"normalized": []
},
{
"id": "split_0_train_7385_entity",
"type": "progene_text",
"text": [
"integration host factor"
],
"offsets": [
[
121,
144
]
],
"normalized": []
},
{
"id": "split_0_train_7386_entity",
"type": "progene_text",
"text": [
"cAMP receptor protein"
],
"offsets": [
[
178,
199
]
],
"normalized": []
},
{
"id": "split_0_train_7387_entity",
"type": "progene_text",
"text": [
"Crp"
],
"offsets": [
[
202,
205
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4688
|
split_0_train_4688
|
[
{
"id": "split_0_train_4688_passage",
"type": "progene_text",
"text": [
"A twofold increase in the induction was observed during anaerobic growth , which was independent of ArcA or Fnr ."
],
"offsets": [
[
0,
113
]
]
}
] |
[
{
"id": "split_0_train_7388_entity",
"type": "progene_text",
"text": [
"ArcA"
],
"offsets": [
[
100,
104
]
],
"normalized": []
},
{
"id": "split_0_train_7389_entity",
"type": "progene_text",
"text": [
"Fnr"
],
"offsets": [
[
108,
111
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4689
|
split_0_train_4689
|
[
{
"id": "split_0_train_4689_passage",
"type": "progene_text",
"text": [
"Gel mobility shift assays showed that the YiaJ repressor binds to a promoter fragment extending from - 50 to + 121 ."
],
"offsets": [
[
0,
116
]
]
}
] |
[
{
"id": "split_0_train_7390_entity",
"type": "progene_text",
"text": [
"YiaJ"
],
"offsets": [
[
42,
46
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4690
|
split_0_train_4690
|
[
{
"id": "split_0_train_4690_passage",
"type": "progene_text",
"text": [
"These studies also showed that the cAMP - Crp complex can bind to two different sites ."
],
"offsets": [
[
0,
87
]
]
}
] |
[
{
"id": "split_0_train_7391_entity",
"type": "progene_text",
"text": [
"Crp"
],
"offsets": [
[
42,
45
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4691
|
split_0_train_4691
|
[
{
"id": "split_0_train_4691_passage",
"type": "progene_text",
"text": [
"The lacZ transcriptional fusions of different fragments of the promoter demonstrated that binding of cAMP - Crp to the Crp site 1 , centered at - 106 , is essential for yiaK - S expression ."
],
"offsets": [
[
0,
190
]
]
}
] |
[
{
"id": "split_0_train_7392_entity",
"type": "progene_text",
"text": [
"lacZ"
],
"offsets": [
[
4,
8
]
],
"normalized": []
},
{
"id": "split_0_train_7393_entity",
"type": "progene_text",
"text": [
"Crp"
],
"offsets": [
[
108,
111
]
],
"normalized": []
},
{
"id": "split_0_train_7394_entity",
"type": "progene_text",
"text": [
"Crp"
],
"offsets": [
[
119,
122
]
],
"normalized": []
},
{
"id": "split_0_train_7395_entity",
"type": "progene_text",
"text": [
"yiaK - S"
],
"offsets": [
[
169,
177
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4692
|
split_0_train_4692
|
[
{
"id": "split_0_train_4692_passage",
"type": "progene_text",
"text": [
"The 5' end of the yiaJ gene was determined , and its promoter region was found to overlap with the divergent yiaK-S promoter ."
],
"offsets": [
[
0,
126
]
]
}
] |
[
{
"id": "split_0_train_7396_entity",
"type": "progene_text",
"text": [
"yiaJ"
],
"offsets": [
[
18,
22
]
],
"normalized": []
},
{
"id": "split_0_train_7397_entity",
"type": "progene_text",
"text": [
"yiaK-S"
],
"offsets": [
[
109,
115
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4693
|
split_0_train_4693
|
[
{
"id": "split_0_train_4693_passage",
"type": "progene_text",
"text": [
"Expression of yiaJ is autogenously regulated and reduced by the binding of Crp - cAMP to the Crp site 1 of the yiaK-S promoter ."
],
"offsets": [
[
0,
128
]
]
}
] |
[
{
"id": "split_0_train_7398_entity",
"type": "progene_text",
"text": [
"yiaJ"
],
"offsets": [
[
14,
18
]
],
"normalized": []
},
{
"id": "split_0_train_7399_entity",
"type": "progene_text",
"text": [
"Crp"
],
"offsets": [
[
75,
78
]
],
"normalized": []
},
{
"id": "split_0_train_7400_entity",
"type": "progene_text",
"text": [
"Crp"
],
"offsets": [
[
93,
96
]
],
"normalized": []
},
{
"id": "split_0_train_7401_entity",
"type": "progene_text",
"text": [
"yiaK-S"
],
"offsets": [
[
111,
117
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4694
|
split_0_train_4694
|
[
{
"id": "split_0_train_4694_passage",
"type": "progene_text",
"text": [
"Role of A and B blood group antigens in the expression of adhesive activity of von Willebrand factor ."
],
"offsets": [
[
0,
102
]
]
}
] |
[
{
"id": "split_0_train_7402_entity",
"type": "progene_text",
"text": [
"A and B blood group antigens"
],
"offsets": [
[
8,
36
]
],
"normalized": []
},
{
"id": "split_0_train_7403_entity",
"type": "progene_text",
"text": [
"von Willebrand factor"
],
"offsets": [
[
79,
100
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4695
|
split_0_train_4695
|
[
{
"id": "split_0_train_4695_passage",
"type": "progene_text",
"text": [
"ABO ( H ) blood group antigens are covalently linked to the oligosaccharide side - chains of von Willebrand factor ( VWF ) ."
],
"offsets": [
[
0,
124
]
]
}
] |
[
{
"id": "split_0_train_7404_entity",
"type": "progene_text",
"text": [
"ABO"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_7405_entity",
"type": "progene_text",
"text": [
"von Willebrand factor"
],
"offsets": [
[
93,
114
]
],
"normalized": []
},
{
"id": "split_0_train_7406_entity",
"type": "progene_text",
"text": [
"VWF"
],
"offsets": [
[
117,
120
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4696
|
split_0_train_4696
|
[
{
"id": "split_0_train_4696_passage",
"type": "progene_text",
"text": [
"In this study , we investigated the role of the A and B antigens in the expression of VWF adhesive activity ."
],
"offsets": [
[
0,
109
]
]
}
] |
[
{
"id": "split_0_train_7407_entity",
"type": "progene_text",
"text": [
"VWF"
],
"offsets": [
[
86,
89
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4697
|
split_0_train_4697
|
[
{
"id": "split_0_train_4697_passage",
"type": "progene_text",
"text": [
"VWF of type A , B or O was purified from fresh frozen plasma ."
],
"offsets": [
[
0,
62
]
]
}
] |
[
{
"id": "split_0_train_7408_entity",
"type": "progene_text",
"text": [
"VWF"
],
"offsets": [
[
0,
3
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4698
|
split_0_train_4698
|
[
{
"id": "split_0_train_4698_passage",
"type": "progene_text",
"text": [
"Presence of A or B antigen on the VWF was confirmed by enzyme - linked immunosorbent assay ( ELISA ) and by immunoblotting with monoclonal anti - A or anti - B ."
],
"offsets": [
[
0,
161
]
]
}
] |
[
{
"id": "split_0_train_7409_entity",
"type": "progene_text",
"text": [
"VWF"
],
"offsets": [
[
34,
37
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4699
|
split_0_train_4699
|
[
{
"id": "split_0_train_4699_passage",
"type": "progene_text",
"text": [
"The A or B antigen was also detected in the 48 / 52 - kDa fragment of the respective VWF after trypsin digestion ."
],
"offsets": [
[
0,
114
]
]
}
] |
[
{
"id": "split_0_train_7410_entity",
"type": "progene_text",
"text": [
"VWF"
],
"offsets": [
[
85,
88
]
],
"normalized": []
},
{
"id": "split_0_train_7411_entity",
"type": "progene_text",
"text": [
"trypsin"
],
"offsets": [
[
95,
102
]
],
"normalized": []
}
] |
[] |
[] |
[] |
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