id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_4400
|
split_0_train_4400
|
[
{
"id": "split_0_train_4400_passage",
"type": "progene_text",
"text": [
"Regulatory regions in the promoter and third intron of the growth hormone gene in rainbow trout , Oncorhynchus mykiss walbaum ."
],
"offsets": [
[
0,
127
]
]
}
] |
[
{
"id": "split_0_train_6885_entity",
"type": "progene_text",
"text": [
"growth hormone"
],
"offsets": [
[
59,
73
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4401
|
split_0_train_4401
|
[
{
"id": "split_0_train_4401_passage",
"type": "progene_text",
"text": [
"The mechanisms involved in the transcriptional regulation of the rainbow trout ( Oncorhynchus mykiss ) growth hormone ( tGH ) gene have been investigated ."
],
"offsets": [
[
0,
155
]
]
}
] |
[
{
"id": "split_0_train_6886_entity",
"type": "progene_text",
"text": [
"growth hormone"
],
"offsets": [
[
103,
117
]
],
"normalized": []
},
{
"id": "split_0_train_6887_entity",
"type": "progene_text",
"text": [
"tGH"
],
"offsets": [
[
120,
123
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4402
|
split_0_train_4402
|
[
{
"id": "split_0_train_4402_passage",
"type": "progene_text",
"text": [
"Transient transfection assays , using deletion mutants of the tGH promoter , demonstrated that the - 226 / + 24 5' - flanking region , bearing three binding sites for the pituitary - specific transcription factor GHF1 / Pit1 and a cAMP - response element , is necessary and sufficient to confer strong tissue - specific and cAMP - stimulated expression to a luciferase reporter gene ."
],
"offsets": [
[
0,
384
]
]
}
] |
[
{
"id": "split_0_train_6888_entity",
"type": "progene_text",
"text": [
"tGH"
],
"offsets": [
[
62,
65
]
],
"normalized": []
},
{
"id": "split_0_train_6889_entity",
"type": "progene_text",
"text": [
"pituitary - specific transcription factor"
],
"offsets": [
[
171,
212
]
],
"normalized": []
},
{
"id": "split_0_train_6890_entity",
"type": "progene_text",
"text": [
"GHF1"
],
"offsets": [
[
213,
217
]
],
"normalized": []
},
{
"id": "split_0_train_6891_entity",
"type": "progene_text",
"text": [
"Pit1"
],
"offsets": [
[
220,
224
]
],
"normalized": []
},
{
"id": "split_0_train_6892_entity",
"type": "progene_text",
"text": [
"luciferase"
],
"offsets": [
[
358,
368
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4403
|
split_0_train_4403
|
[
{
"id": "split_0_train_4403_passage",
"type": "progene_text",
"text": [
"This region is also upregulated by the synthetic glucocorticoid dexamethasone ( DEX ) , the combined effects of cAMP , and DEX being synergistic ."
],
"offsets": [
[
0,
146
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4404
|
split_0_train_4404
|
[
{
"id": "split_0_train_4404_passage",
"type": "progene_text",
"text": [
"Footprinting and gel shift assays revealed that GHF1 binds to a recognition element in the third intron of the tGH gene , suggesting that GHF1 can affect the expression of this gene by interacting with response elements in the transcription unit ."
],
"offsets": [
[
0,
247
]
]
}
] |
[
{
"id": "split_0_train_6893_entity",
"type": "progene_text",
"text": [
"GHF1"
],
"offsets": [
[
48,
52
]
],
"normalized": []
},
{
"id": "split_0_train_6894_entity",
"type": "progene_text",
"text": [
"tGH"
],
"offsets": [
[
111,
114
]
],
"normalized": []
},
{
"id": "split_0_train_6895_entity",
"type": "progene_text",
"text": [
"GHF1"
],
"offsets": [
[
138,
142
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4405
|
split_0_train_4405
|
[
{
"id": "split_0_train_4405_passage",
"type": "progene_text",
"text": [
"These results may be exploited to design tGH gene constructs for the production of autotransgenic fish , in which the expression of the isospecific transgene driven by a constitutive proximal promoter is specifically targeted to the pituitary and physiologically controlled ."
],
"offsets": [
[
0,
275
]
]
}
] |
[
{
"id": "split_0_train_6896_entity",
"type": "progene_text",
"text": [
"tGH"
],
"offsets": [
[
41,
44
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4406
|
split_0_train_4406
|
[
{
"id": "split_0_train_4406_passage",
"type": "progene_text",
"text": [
"Glycosylation of homologous immunodominant proteins of Ehrlichia chaffeensis and Ehrlichia canis ."
],
"offsets": [
[
0,
98
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4407
|
split_0_train_4407
|
[
{
"id": "split_0_train_4407_passage",
"type": "progene_text",
"text": [
"The glycoprotein genes of Ehrlichia chaffeensis ( 1 , 644 bp ) and Ehrlichia canis ( 2 , 064 bp ) encode proteins of 548 to 688 amino acids with predicted molecular masses of only 61 and 73 kDa but with electrophoretic mobilities of 120 kDa ( P120 ) and 140 kDa ( P140 ) , respectively ."
],
"offsets": [
[
0,
287
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4408
|
split_0_train_4408
|
[
{
"id": "split_0_train_4408_passage",
"type": "progene_text",
"text": [
"The 120 - kDa protein gene of E. chaffeensis contains four identical 240 - bp tandem repeat units , and the 140 - kDa protein gene of E. canis has 14 nearly identical , tandemly arranged 108 - bp repeat units ."
],
"offsets": [
[
0,
210
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4409
|
split_0_train_4409
|
[
{
"id": "split_0_train_4409_passage",
"type": "progene_text",
"text": [
"Conserved serine - rich motifs identified in the repeat units of P120 and P140 were also found in the repeat units of the human granulocytotropic ehrlichiosis agent 130 - kDa protein and of the fimbria - associated adhesin protein Fap1 of Streptococcus parasanguis ."
],
"offsets": [
[
0,
266
]
]
}
] |
[
{
"id": "split_0_train_6897_entity",
"type": "progene_text",
"text": [
"fimbria - associated adhesin protein Fap1"
],
"offsets": [
[
194,
235
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4410
|
split_0_train_4410
|
[
{
"id": "split_0_train_4410_passage",
"type": "progene_text",
"text": [
"Nearly the entire ( 99 % ) E. chaffeensis P120 gene ( 1 , 616 bp ) , the 14 - repeat region ( 78 % ) of the E. canis P140 gene ( 1 , 620 bp ) , and a 2 - repeat region from the E. chaffeensis P120 gene ( 520 bp ) were expressed in Escherichia coli ."
],
"offsets": [
[
0,
249
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4411
|
split_0_train_4411
|
[
{
"id": "split_0_train_4411_passage",
"type": "progene_text",
"text": [
"The recombinant proteins exhibited molecular masses ranging from 1.6 to 2 times larger than those predicted by the amino acid sequences ."
],
"offsets": [
[
0,
137
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4412
|
split_0_train_4412
|
[
{
"id": "split_0_train_4412_passage",
"type": "progene_text",
"text": [
"Antibodies against the recombinant proteins reacted with E. chaffeensis P120 and E. canis P140 , respectively ."
],
"offsets": [
[
0,
111
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4413
|
split_0_train_4413
|
[
{
"id": "split_0_train_4413_passage",
"type": "progene_text",
"text": [
"Carbohydrate was detected on the E. chaffeensis and E. canis recombinant proteins , including the two - repeat polypeptide region of E. chaffeensis P120 ."
],
"offsets": [
[
0,
154
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4414
|
split_0_train_4414
|
[
{
"id": "split_0_train_4414_passage",
"type": "progene_text",
"text": [
"A carbohydrate compositional analysis identified glucose , galactose , and xylose on the recombinant proteins ."
],
"offsets": [
[
0,
111
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4415
|
split_0_train_4415
|
[
{
"id": "split_0_train_4415_passage",
"type": "progene_text",
"text": [
"The presence of only one site for N-linked ( Asn-Xaa-Ser / Thr ) glycosylation , a lack of effect of N-glycosidase F , the presence of 70 and 126 Ser / Thr glycosylation sites in the repeat regions of P120 and P140 , respectively , and a high molar ratio of carbohydrate to protein suggest that the glycans may be O linked ."
],
"offsets": [
[
0,
324
]
]
}
] |
[
{
"id": "split_0_train_6898_entity",
"type": "progene_text",
"text": [
"N-glycosidase F"
],
"offsets": [
[
101,
116
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4416
|
split_0_train_4416
|
[
{
"id": "split_0_train_4416_passage",
"type": "progene_text",
"text": [
"Identification and characterization of a new prespore - specific regulatory gene , rsfA , of Bacillus subtilis ."
],
"offsets": [
[
0,
112
]
]
}
] |
[
{
"id": "split_0_train_6899_entity",
"type": "progene_text",
"text": [
"rsfA"
],
"offsets": [
[
83,
87
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4417
|
split_0_train_4417
|
[
{
"id": "split_0_train_4417_passage",
"type": "progene_text",
"text": [
"Differential gene expression during Bacillus subtilis sporulation is controlled by sigma factors and other regulatory effectors ."
],
"offsets": [
[
0,
129
]
]
}
] |
[
{
"id": "split_0_train_6900_entity",
"type": "progene_text",
"text": [
"sigma factors"
],
"offsets": [
[
83,
96
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4418
|
split_0_train_4418
|
[
{
"id": "split_0_train_4418_passage",
"type": "progene_text",
"text": [
"The first compartmentalized sigma factor , sigma ( F ) , is active specifically in the prespore compartment ."
],
"offsets": [
[
0,
109
]
]
}
] |
[
{
"id": "split_0_train_6901_entity",
"type": "progene_text",
"text": [
"sigma factor"
],
"offsets": [
[
28,
40
]
],
"normalized": []
},
{
"id": "split_0_train_6902_entity",
"type": "progene_text",
"text": [
"sigma ( F )"
],
"offsets": [
[
43,
54
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4419
|
split_0_train_4419
|
[
{
"id": "split_0_train_4419_passage",
"type": "progene_text",
"text": [
"During our screening for new chromosome segregation mutants using a sigma ( F ) - dependent gpr - lacZ reporter as a probe , we identified a new gene ( ywfN ) required for maximal expression of the reporter and named it rsfA ."
],
"offsets": [
[
0,
226
]
]
}
] |
[
{
"id": "split_0_train_6903_entity",
"type": "progene_text",
"text": [
"sigma ( F )"
],
"offsets": [
[
68,
79
]
],
"normalized": []
},
{
"id": "split_0_train_6904_entity",
"type": "progene_text",
"text": [
"gpr"
],
"offsets": [
[
92,
95
]
],
"normalized": []
},
{
"id": "split_0_train_6905_entity",
"type": "progene_text",
"text": [
"lacZ"
],
"offsets": [
[
98,
102
]
],
"normalized": []
},
{
"id": "split_0_train_6906_entity",
"type": "progene_text",
"text": [
"ywfN"
],
"offsets": [
[
152,
156
]
],
"normalized": []
},
{
"id": "split_0_train_6907_entity",
"type": "progene_text",
"text": [
"rsfA"
],
"offsets": [
[
220,
224
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4420
|
split_0_train_4420
|
[
{
"id": "split_0_train_4420_passage",
"type": "progene_text",
"text": [
"The product of rsfA has features of gene regulatory proteins , and the protein colocalizes with DNA ."
],
"offsets": [
[
0,
101
]
]
}
] |
[
{
"id": "split_0_train_6908_entity",
"type": "progene_text",
"text": [
"rsfA"
],
"offsets": [
[
15,
19
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4421
|
split_0_train_4421
|
[
{
"id": "split_0_train_4421_passage",
"type": "progene_text",
"text": [
"The expression of rsfA is under the control of both sigma ( F ) and sigma ( G ) ."
],
"offsets": [
[
0,
81
]
]
}
] |
[
{
"id": "split_0_train_6909_entity",
"type": "progene_text",
"text": [
"rsfA"
],
"offsets": [
[
18,
22
]
],
"normalized": []
},
{
"id": "split_0_train_6910_entity",
"type": "progene_text",
"text": [
"sigma ( F )"
],
"offsets": [
[
52,
63
]
],
"normalized": []
},
{
"id": "split_0_train_6911_entity",
"type": "progene_text",
"text": [
"sigma ( G )"
],
"offsets": [
[
68,
79
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4422
|
split_0_train_4422
|
[
{
"id": "split_0_train_4422_passage",
"type": "progene_text",
"text": [
"Null mutations in rsfA have different effects on the expression of sigma(F) - dependent genes , suggesting that the RsfA protein is a regulator of transcription that fine - tunes gene expression in the prespore ."
],
"offsets": [
[
0,
212
]
]
}
] |
[
{
"id": "split_0_train_6912_entity",
"type": "progene_text",
"text": [
"rsfA"
],
"offsets": [
[
18,
22
]
],
"normalized": []
},
{
"id": "split_0_train_6913_entity",
"type": "progene_text",
"text": [
"sigma(F)"
],
"offsets": [
[
67,
75
]
],
"normalized": []
},
{
"id": "split_0_train_6914_entity",
"type": "progene_text",
"text": [
"RsfA"
],
"offsets": [
[
116,
120
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4423
|
split_0_train_4423
|
[
{
"id": "split_0_train_4423_passage",
"type": "progene_text",
"text": [
"ESE-3 , a novel member of an epithelium - specific ets transcription factor subfamily , demonstrates different target gene specificity from ESE-1 ."
],
"offsets": [
[
0,
147
]
]
}
] |
[
{
"id": "split_0_train_6915_entity",
"type": "progene_text",
"text": [
"ESE-3"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "split_0_train_6916_entity",
"type": "progene_text",
"text": [
"epithelium - specific ets transcription factor subfamily"
],
"offsets": [
[
29,
85
]
],
"normalized": []
},
{
"id": "split_0_train_6917_entity",
"type": "progene_text",
"text": [
"ESE-1"
],
"offsets": [
[
140,
145
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4424
|
split_0_train_4424
|
[
{
"id": "split_0_train_4424_passage",
"type": "progene_text",
"text": [
"Most cancers originate as a result of aberrant gene expression in mainly glandular epithelial tissues leading to defects in epithelial cell differentiation ."
],
"offsets": [
[
0,
157
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4425
|
split_0_train_4425
|
[
{
"id": "split_0_train_4425_passage",
"type": "progene_text",
"text": [
"The latter is governed by distinct sets of transcriptional regulators ."
],
"offsets": [
[
0,
71
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4426
|
split_0_train_4426
|
[
{
"id": "split_0_train_4426_passage",
"type": "progene_text",
"text": [
"Here we report the characterization of epithelium - specific Ets factor , family member 3 ( ESE-3 ) , a novel member of the ESE subfamily of Ets transcription factors ."
],
"offsets": [
[
0,
168
]
]
}
] |
[
{
"id": "split_0_train_6918_entity",
"type": "progene_text",
"text": [
"epithelium - specific Ets factor , family member 3"
],
"offsets": [
[
39,
89
]
],
"normalized": []
},
{
"id": "split_0_train_6919_entity",
"type": "progene_text",
"text": [
"ESE-3"
],
"offsets": [
[
92,
97
]
],
"normalized": []
},
{
"id": "split_0_train_6920_entity",
"type": "progene_text",
"text": [
"ESE subfamily of Ets transcription factors"
],
"offsets": [
[
124,
166
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4427
|
split_0_train_4427
|
[
{
"id": "split_0_train_4427_passage",
"type": "progene_text",
"text": [
"ESE-3 shows highest homology to two other epithelium restricted Ets factors , ESE-1 and ESE-2 ."
],
"offsets": [
[
0,
95
]
]
}
] |
[
{
"id": "split_0_train_6921_entity",
"type": "progene_text",
"text": [
"ESE-3"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "split_0_train_6922_entity",
"type": "progene_text",
"text": [
"Ets"
],
"offsets": [
[
64,
67
]
],
"normalized": []
},
{
"id": "split_0_train_6923_entity",
"type": "progene_text",
"text": [
"ESE-1"
],
"offsets": [
[
78,
83
]
],
"normalized": []
},
{
"id": "split_0_train_6924_entity",
"type": "progene_text",
"text": [
"ESE-2"
],
"offsets": [
[
88,
93
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4428
|
split_0_train_4428
|
[
{
"id": "split_0_train_4428_passage",
"type": "progene_text",
"text": [
"ESE-3 , like ESE-1 and ESE-2 , is exclusively expressed in a subset of epithelial cells with highest expression in glandular epithelium such as prostate , pancreas , salivary gland , and trachea ."
],
"offsets": [
[
0,
196
]
]
}
] |
[
{
"id": "split_0_train_6925_entity",
"type": "progene_text",
"text": [
"ESE-3"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "split_0_train_6926_entity",
"type": "progene_text",
"text": [
"ESE-1"
],
"offsets": [
[
13,
18
]
],
"normalized": []
},
{
"id": "split_0_train_6927_entity",
"type": "progene_text",
"text": [
"ESE-2"
],
"offsets": [
[
23,
28
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4429
|
split_0_train_4429
|
[
{
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"text": [
"A potential role in branching morphogenesis is suggested , since ESE-3 transactivates the c-MET promoter via three high affinity binding sites ."
],
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[
0,
144
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]
}
] |
[
{
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65,
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{
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"type": "progene_text",
"text": [
"c-MET"
],
"offsets": [
[
90,
95
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4430
|
split_0_train_4430
|
[
{
"id": "split_0_train_4430_passage",
"type": "progene_text",
"text": [
"Additionally , ESE-3 binding to DNA sequences in the promoters of several glandular epithelium - specific genes suggests a role for ESE-3 in later stages of glandular epithelium differentiation ."
],
"offsets": [
[
0,
195
]
]
}
] |
[
{
"id": "split_0_train_6930_entity",
"type": "progene_text",
"text": [
"ESE-3"
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15,
20
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{
"id": "split_0_train_6931_entity",
"type": "progene_text",
"text": [
"ESE-3"
],
"offsets": [
[
132,
137
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4431
|
split_0_train_4431
|
[
{
"id": "split_0_train_4431_passage",
"type": "progene_text",
"text": [
"Although ESE-3 and ESE-1 bind with similar affinity to various Ets binding sites , ESE-3 and ESE-1 differ significantly in their ability to transactivate the promoters containing these sites ."
],
"offsets": [
[
0,
192
]
]
}
] |
[
{
"id": "split_0_train_6932_entity",
"type": "progene_text",
"text": [
"ESE-3"
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[
9,
14
]
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},
{
"id": "split_0_train_6933_entity",
"type": "progene_text",
"text": [
"ESE-1"
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19,
24
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],
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},
{
"id": "split_0_train_6934_entity",
"type": "progene_text",
"text": [
"Ets"
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63,
66
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],
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},
{
"id": "split_0_train_6935_entity",
"type": "progene_text",
"text": [
"ESE-3"
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83,
88
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{
"id": "split_0_train_6936_entity",
"type": "progene_text",
"text": [
"ESE-1"
],
"offsets": [
[
93,
98
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4432
|
split_0_train_4432
|
[
{
"id": "split_0_train_4432_passage",
"type": "progene_text",
"text": [
"Our results support the notion that ESE-1 , ESE-2 , and ESE-3 represent a unique epithelium - specific subfamily of Ets factors that have critical but distinct functions in epithelial cell differentiation and proliferation ."
],
"offsets": [
[
0,
224
]
]
}
] |
[
{
"id": "split_0_train_6937_entity",
"type": "progene_text",
"text": [
"ESE-1"
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36,
41
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{
"id": "split_0_train_6938_entity",
"type": "progene_text",
"text": [
"ESE-2"
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44,
49
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},
{
"id": "split_0_train_6939_entity",
"type": "progene_text",
"text": [
"ESE-3"
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[
56,
61
]
],
"normalized": []
},
{
"id": "split_0_train_6940_entity",
"type": "progene_text",
"text": [
"epithelium - specific subfamily of Ets factors"
],
"offsets": [
[
81,
127
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4433
|
split_0_train_4433
|
[
{
"id": "split_0_train_4433_passage",
"type": "progene_text",
"text": [
"Phenotypic variability and origins of mutations in the gene encoding 3beta-hydroxysteroid dehydrogenase type II ."
],
"offsets": [
[
0,
113
]
]
}
] |
[
{
"id": "split_0_train_6941_entity",
"type": "progene_text",
"text": [
"3beta-hydroxysteroid dehydrogenase type II"
],
"offsets": [
[
69,
111
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4434
|
split_0_train_4434
|
[
{
"id": "split_0_train_4434_passage",
"type": "progene_text",
"text": [
"Mutations in HSD3B2 , the gene for 3beta-hydroxysteroid dehydrogenase type II ( 3beta-HSD II ) have been detected and activities analysed through the in vitro expression of mutant cDNAs ."
],
"offsets": [
[
0,
187
]
]
}
] |
[
{
"id": "split_0_train_6942_entity",
"type": "progene_text",
"text": [
"HSD3B2"
],
"offsets": [
[
13,
19
]
],
"normalized": []
},
{
"id": "split_0_train_6943_entity",
"type": "progene_text",
"text": [
"3beta-hydroxysteroid dehydrogenase type II"
],
"offsets": [
[
35,
77
]
],
"normalized": []
},
{
"id": "split_0_train_6944_entity",
"type": "progene_text",
"text": [
"3beta-HSD II"
],
"offsets": [
[
80,
92
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4435
|
split_0_train_4435
|
[
{
"id": "split_0_train_4435_passage",
"type": "progene_text",
"text": [
"Two full sibs with male pseudohermaphroditism were found to be double heterozygotes : N100S / 266DeltaA ."
],
"offsets": [
[
0,
105
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4436
|
split_0_train_4436
|
[
{
"id": "split_0_train_4436_passage",
"type": "progene_text",
"text": [
"This genotype leads to the most profound loss of 3beta-HSD II enzyme activity ( 1.3 % of normal ) described to date in cases without severe salt - loss ."
],
"offsets": [
[
0,
153
]
]
}
] |
[
{
"id": "split_0_train_6945_entity",
"type": "progene_text",
"text": [
"3beta-HSD II"
],
"offsets": [
[
49,
61
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4437
|
split_0_train_4437
|
[
{
"id": "split_0_train_4437_passage",
"type": "progene_text",
"text": [
"One sib ( N100S / 266DeltaA ) is the first reported male case of type II deficiency affected with premature adrenarche ."
],
"offsets": [
[
0,
120
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4438
|
split_0_train_4438
|
[
{
"id": "split_0_train_4438_passage",
"type": "progene_text",
"text": [
"Three apparently independent kindreds had propositi affected with the HSD3B2 mutation A82T / A82T , which is associated with a non salt - losing phenotype with variable expressivity in females ."
],
"offsets": [
[
0,
194
]
]
}
] |
[
{
"id": "split_0_train_6946_entity",
"type": "progene_text",
"text": [
"HSD3B2"
],
"offsets": [
[
70,
76
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4439
|
split_0_train_4439
|
[
{
"id": "split_0_train_4439_passage",
"type": "progene_text",
"text": [
"These three families had the same extended HSD3B haplotype and are likely to have inherited the same ancestral mutation ."
],
"offsets": [
[
0,
121
]
]
}
] |
[
{
"id": "split_0_train_6947_entity",
"type": "progene_text",
"text": [
"HSD3B"
],
"offsets": [
[
43,
48
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4440
|
split_0_train_4440
|
[
{
"id": "split_0_train_4440_passage",
"type": "progene_text",
"text": [
"The significance of this finding is discussed in the light of the presence of A82T mutation at a homologous position in pseudogene varphi5 that is present in the HSD3B cluster ."
],
"offsets": [
[
0,
177
]
]
}
] |
[
{
"id": "split_0_train_6948_entity",
"type": "progene_text",
"text": [
"HSD3B"
],
"offsets": [
[
162,
167
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4441
|
split_0_train_4441
|
[
{
"id": "split_0_train_4441_passage",
"type": "progene_text",
"text": [
"Tyrosine 462 of the membrane - proximal F'-G' loop of murine Mpl is not essential for high - affinity binding of thrombopoietin ."
],
"offsets": [
[
0,
129
]
]
}
] |
[
{
"id": "split_0_train_6949_entity",
"type": "progene_text",
"text": [
"Mpl"
],
"offsets": [
[
61,
64
]
],
"normalized": []
},
{
"id": "split_0_train_6950_entity",
"type": "progene_text",
"text": [
"thrombopoietin"
],
"offsets": [
[
113,
127
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4442
|
split_0_train_4442
|
[
{
"id": "split_0_train_4442_passage",
"type": "progene_text",
"text": [
"The ligand binding site of Mpl , the thrombopoietin ( Tpo ) receptor , has not been determined ."
],
"offsets": [
[
0,
96
]
]
}
] |
[
{
"id": "split_0_train_6951_entity",
"type": "progene_text",
"text": [
"Mpl"
],
"offsets": [
[
27,
30
]
],
"normalized": []
},
{
"id": "split_0_train_6952_entity",
"type": "progene_text",
"text": [
"thrombopoietin ( Tpo ) receptor"
],
"offsets": [
[
37,
68
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4443
|
split_0_train_4443
|
[
{
"id": "split_0_train_4443_passage",
"type": "progene_text",
"text": [
"Tyr(462) of murine Mpl corresponds to Tyr(421) of the common beta chain of the human IL-3 , IL-5 and GM-CSF receptors ."
],
"offsets": [
[
0,
119
]
]
}
] |
[
{
"id": "split_0_train_6953_entity",
"type": "progene_text",
"text": [
"Mpl"
],
"offsets": [
[
19,
22
]
],
"normalized": []
},
{
"id": "split_0_train_6954_entity",
"type": "progene_text",
"text": [
"common beta chain of the human IL-3 , IL-5 and GM-CSF receptors"
],
"offsets": [
[
54,
117
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4444
|
split_0_train_4444
|
[
{
"id": "split_0_train_4444_passage",
"type": "progene_text",
"text": [
"Tyr(421) has been identified as essential for high - affinity ligand binding ."
],
"offsets": [
[
0,
78
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4445
|
split_0_train_4445
|
[
{
"id": "split_0_train_4445_passage",
"type": "progene_text",
"text": [
"To determine whether Tyr(462) is similarly required for Tpo binding , wild - type murine Mpl ( Mpl - WT ) or mutant receptors containing an alanine ( Y462A ) or lysine ( Y462K ) in place of Tyr(462) were expressed in BaF3 cells ."
],
"offsets": [
[
0,
229
]
]
}
] |
[
{
"id": "split_0_train_6955_entity",
"type": "progene_text",
"text": [
"Tpo"
],
"offsets": [
[
56,
59
]
],
"normalized": []
},
{
"id": "split_0_train_6956_entity",
"type": "progene_text",
"text": [
"Mpl"
],
"offsets": [
[
89,
92
]
],
"normalized": []
},
{
"id": "split_0_train_6957_entity",
"type": "progene_text",
"text": [
"Mpl"
],
"offsets": [
[
95,
98
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4446
|
split_0_train_4446
|
[
{
"id": "split_0_train_4446_passage",
"type": "progene_text",
"text": [
"In proliferation studies , the Y462A mutation had no effect on Tpo - induced growth ."
],
"offsets": [
[
0,
85
]
]
}
] |
[
{
"id": "split_0_train_6958_entity",
"type": "progene_text",
"text": [
"Tpo"
],
"offsets": [
[
63,
66
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4447
|
split_0_train_4447
|
[
{
"id": "split_0_train_4447_passage",
"type": "progene_text",
"text": [
"In contrast , the Y462K mutation led to an attenuated proliferative response to Tpo ."
],
"offsets": [
[
0,
85
]
]
}
] |
[
{
"id": "split_0_train_6959_entity",
"type": "progene_text",
"text": [
"Tpo"
],
"offsets": [
[
80,
83
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4448
|
split_0_train_4448
|
[
{
"id": "split_0_train_4448_passage",
"type": "progene_text",
"text": [
"In single - point binding studies , both Mpl - WT and Y462A cells were able to bind [(125)I] Tpo in a specific manner ."
],
"offsets": [
[
0,
119
]
]
}
] |
[
{
"id": "split_0_train_6960_entity",
"type": "progene_text",
"text": [
"Mpl"
],
"offsets": [
[
41,
44
]
],
"normalized": []
},
{
"id": "split_0_train_6961_entity",
"type": "progene_text",
"text": [
"Tpo"
],
"offsets": [
[
93,
96
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4449
|
split_0_train_4449
|
[
{
"id": "split_0_train_4449_passage",
"type": "progene_text",
"text": [
"In contrast , there was a marked reduction in binding of [(125)I] Tpo by Y462K cells ."
],
"offsets": [
[
0,
86
]
]
}
] |
[
{
"id": "split_0_train_6962_entity",
"type": "progene_text",
"text": [
"Tpo"
],
"offsets": [
[
66,
69
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4450
|
split_0_train_4450
|
[
{
"id": "split_0_train_4450_passage",
"type": "progene_text",
"text": [
"Mpl - WT cells bound Tpo with a K(d) of approximately 330 pM , while Y462A cells bound Tpo with a K(d) of approximately 268 pM ."
],
"offsets": [
[
0,
128
]
]
}
] |
[
{
"id": "split_0_train_6963_entity",
"type": "progene_text",
"text": [
"Mpl"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_6964_entity",
"type": "progene_text",
"text": [
"Tpo"
],
"offsets": [
[
21,
24
]
],
"normalized": []
},
{
"id": "split_0_train_6965_entity",
"type": "progene_text",
"text": [
"Tpo"
],
"offsets": [
[
87,
90
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4451
|
split_0_train_4451
|
[
{
"id": "split_0_train_4451_passage",
"type": "progene_text",
"text": [
"The binding affinity of Y462K cells was below that quantifiable by Scatchard analysis ."
],
"offsets": [
[
0,
87
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4452
|
split_0_train_4452
|
[
{
"id": "split_0_train_4452_passage",
"type": "progene_text",
"text": [
"This study suggests that unlike the corresponding Tyr(421) of the common human beta chain , Tyr(462) of murine Mpl is not required for high - affinity ligand binding , although it may be located in proximity to the ligand binding site ."
],
"offsets": [
[
0,
236
]
]
}
] |
[
{
"id": "split_0_train_6966_entity",
"type": "progene_text",
"text": [
"Mpl"
],
"offsets": [
[
111,
114
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4453
|
split_0_train_4453
|
[
{
"id": "split_0_train_4453_passage",
"type": "progene_text",
"text": [
"Cloning and characterization of additional members of the G protein - coupled receptor family ."
],
"offsets": [
[
0,
95
]
]
}
] |
[
{
"id": "split_0_train_6967_entity",
"type": "progene_text",
"text": [
"G protein - coupled receptor family"
],
"offsets": [
[
58,
93
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4454
|
split_0_train_4454
|
[
{
"id": "split_0_train_4454_passage",
"type": "progene_text",
"text": [
"A search of the expressed sequence tag ( EST ) database retrieved a human cDNA sequence which partially encoded a novel G protein - coupled receptor ( GPCR ) GPR26 ."
],
"offsets": [
[
0,
165
]
]
}
] |
[
{
"id": "split_0_train_6968_entity",
"type": "progene_text",
"text": [
"G protein - coupled receptor"
],
"offsets": [
[
120,
148
]
],
"normalized": []
},
{
"id": "split_0_train_6969_entity",
"type": "progene_text",
"text": [
"GPCR"
],
"offsets": [
[
151,
155
]
],
"normalized": []
},
{
"id": "split_0_train_6970_entity",
"type": "progene_text",
"text": [
"GPR26"
],
"offsets": [
[
158,
163
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4455
|
split_0_train_4455
|
[
{
"id": "split_0_train_4455_passage",
"type": "progene_text",
"text": [
"A human genomic DNA fragment encoding a partial open reading frame ( ORF ) and a rat cDNA encoding the full length ORF of GPR26 were obtained by library screening ."
],
"offsets": [
[
0,
164
]
]
}
] |
[
{
"id": "split_0_train_6971_entity",
"type": "progene_text",
"text": [
"GPR26"
],
"offsets": [
[
122,
127
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4456
|
split_0_train_4456
|
[
{
"id": "split_0_train_4456_passage",
"type": "progene_text",
"text": [
"The rat GPR26 cDNA encoded a protein of 317 amino acids , most similar ( albeit distantly related ) to the serotonin 5-HT(5A) and gastrin releasing hormone BB2 receptors ."
],
"offsets": [
[
0,
171
]
]
}
] |
[
{
"id": "split_0_train_6972_entity",
"type": "progene_text",
"text": [
"GPR26"
],
"offsets": [
[
8,
13
]
],
"normalized": []
},
{
"id": "split_0_train_6973_entity",
"type": "progene_text",
"text": [
"serotonin 5-HT(5A)"
],
"offsets": [
[
107,
125
]
],
"normalized": []
},
{
"id": "split_0_train_6974_entity",
"type": "progene_text",
"text": [
"gastrin releasing hormone BB2 receptors"
],
"offsets": [
[
130,
169
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4457
|
split_0_train_4457
|
[
{
"id": "split_0_train_4457_passage",
"type": "progene_text",
"text": [
"GPR26 mRNA expression analysis revealed signals in the striatum , pons , cerebellum and cortex ."
],
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[
0,
96
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]
}
] |
[
{
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"type": "progene_text",
"text": [
"GPR26"
],
"offsets": [
[
0,
5
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}
] |
[] |
[] |
[] |
split_0_train_4458
|
split_0_train_4458
|
[
{
"id": "split_0_train_4458_passage",
"type": "progene_text",
"text": [
"HEK293 and Rh7777 cells transfected with GPR26 cDNA displayed high basal cAMP levels , slow growth rate of clonal populations and derangements of normal cell shape ."
],
"offsets": [
[
0,
165
]
]
}
] |
[
{
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"type": "progene_text",
"text": [
"GPR26"
],
"offsets": [
[
41,
46
]
],
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}
] |
[] |
[] |
[] |
split_0_train_4459
|
split_0_train_4459
|
[
{
"id": "split_0_train_4459_passage",
"type": "progene_text",
"text": [
"We also used a sequence reported only in the patent literature encoding GPR57 ( a.k.a. HNHCI32 ) to PCR amplify a DNA fragment which was used to screen a human genomic library ."
],
"offsets": [
[
0,
177
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]
}
] |
[
{
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"type": "progene_text",
"text": [
"GPR57"
],
"offsets": [
[
72,
77
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4460
|
split_0_train_4460
|
[
{
"id": "split_0_train_4460_passage",
"type": "progene_text",
"text": [
"This resulted in the cloning of a genomic fragment containing a pseudogene , psiGPR57 , with a 99.6 % nucleotide identity to GPR57 ."
],
"offsets": [
[
0,
132
]
]
}
] |
[
{
"id": "split_0_train_6978_entity",
"type": "progene_text",
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"psiGPR57"
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77,
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{
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"type": "progene_text",
"text": [
"GPR57"
],
"offsets": [
[
125,
130
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4461
|
split_0_train_4461
|
[
{
"id": "split_0_train_4461_passage",
"type": "progene_text",
"text": [
"Based on shared sequence identities , the receptor encoded by GPR57 was predicted to belong to a novel subfamily of GPCRs together with GPR58 ( a.k.a. phBL5 , reported only in the patent literature ) , putative neurotransmitter receptor ( PNR ) and a 5-HT(4) pseudogene ."
],
"offsets": [
[
0,
271
]
]
}
] |
[
{
"id": "split_0_train_6980_entity",
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62,
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116,
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136,
141
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{
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"text": [
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202,
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{
"id": "split_0_train_6984_entity",
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239,
242
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{
"id": "split_0_train_6985_entity",
"type": "progene_text",
"text": [
"5-HT(4) pseudogene"
],
"offsets": [
[
251,
269
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4462
|
split_0_train_4462
|
[
{
"id": "split_0_train_4462_passage",
"type": "progene_text",
"text": [
"Analysis of this subfamily revealed greatest identities ( approximately 56 % ) between the receptors encoded by GPR57 and GPR58 , each with shared identities of approximately 40 % with PNR ."
],
"offsets": [
[
0,
190
]
]
}
] |
[
{
"id": "split_0_train_6986_entity",
"type": "progene_text",
"text": [
"GPR57"
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112,
117
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"normalized": []
},
{
"id": "split_0_train_6987_entity",
"type": "progene_text",
"text": [
"GPR58"
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122,
127
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"normalized": []
},
{
"id": "split_0_train_6988_entity",
"type": "progene_text",
"text": [
"PNR"
],
"offsets": [
[
185,
188
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4463
|
split_0_train_4463
|
[
{
"id": "split_0_train_4463_passage",
"type": "progene_text",
"text": [
"Furthermore , psiGPR57 , GPR58 , PNR and the 5-HT(4) pseudogene were mapped in a cluster localized to chromosome 6q22 - 24 ."
],
"offsets": [
[
0,
124
]
]
}
] |
[
{
"id": "split_0_train_6989_entity",
"type": "progene_text",
"text": [
"psiGPR57"
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[
14,
22
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},
{
"id": "split_0_train_6990_entity",
"type": "progene_text",
"text": [
"GPR58"
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"offsets": [
[
25,
30
]
],
"normalized": []
},
{
"id": "split_0_train_6991_entity",
"type": "progene_text",
"text": [
"PNR"
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"offsets": [
[
33,
36
]
],
"normalized": []
},
{
"id": "split_0_train_6992_entity",
"type": "progene_text",
"text": [
"5-HT(4) pseudogene"
],
"offsets": [
[
45,
63
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4464
|
split_0_train_4464
|
[
{
"id": "split_0_train_4464_passage",
"type": "progene_text",
"text": [
"PNR and GPR58 were expressed in COS cells , however no specific binding was observed for various serotonin receptor - specific ligands ."
],
"offsets": [
[
0,
136
]
]
}
] |
[
{
"id": "split_0_train_6993_entity",
"type": "progene_text",
"text": [
"PNR"
],
"offsets": [
[
0,
3
]
],
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},
{
"id": "split_0_train_6994_entity",
"type": "progene_text",
"text": [
"GPR58"
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[
8,
13
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],
"normalized": []
},
{
"id": "split_0_train_6995_entity",
"type": "progene_text",
"text": [
"serotonin receptor"
],
"offsets": [
[
97,
115
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4465
|
split_0_train_4465
|
[
{
"id": "split_0_train_4465_passage",
"type": "progene_text",
"text": [
"The RcsAB box ."
],
"offsets": [
[
0,
15
]
]
}
] |
[
{
"id": "split_0_train_6996_entity",
"type": "progene_text",
"text": [
"RcsAB"
],
"offsets": [
[
4,
9
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4466
|
split_0_train_4466
|
[
{
"id": "split_0_train_4466_passage",
"type": "progene_text",
"text": [
"Characterization of a new operator essential for the regulation of exopolysaccharide biosynthesis in enteric bacteria ."
],
"offsets": [
[
0,
119
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4467
|
split_0_train_4467
|
[
{
"id": "split_0_train_4467_passage",
"type": "progene_text",
"text": [
"The interaction of the two transcriptional regulators RcsA and RcsB with a specific operator is a common mechanism in the activation of capsule biosynthesis in enteric bacteria ."
],
"offsets": [
[
0,
178
]
]
}
] |
[
{
"id": "split_0_train_6997_entity",
"type": "progene_text",
"text": [
"RcsA"
],
"offsets": [
[
54,
58
]
],
"normalized": []
},
{
"id": "split_0_train_6998_entity",
"type": "progene_text",
"text": [
"RcsB"
],
"offsets": [
[
63,
67
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4468
|
split_0_train_4468
|
[
{
"id": "split_0_train_4468_passage",
"type": "progene_text",
"text": [
"We describe RcsAB binding sites in the wza promoter of the operon for colanic acid biosynthesis in Escherichia coli K-12 , in the galF promoter of the operon for K2 antigen biosynthesis in Klebsiella pneumoniae , and in the tviA ( vipR ) promoter of the operon for Vi antigen biosynthesis in Salmonella typhi ."
],
"offsets": [
[
0,
310
]
]
}
] |
[
{
"id": "split_0_train_6999_entity",
"type": "progene_text",
"text": [
"RcsAB"
],
"offsets": [
[
12,
17
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],
"normalized": []
},
{
"id": "split_0_train_7000_entity",
"type": "progene_text",
"text": [
"wza"
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"offsets": [
[
39,
42
]
],
"normalized": []
},
{
"id": "split_0_train_7001_entity",
"type": "progene_text",
"text": [
"galF"
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"offsets": [
[
130,
134
]
],
"normalized": []
},
{
"id": "split_0_train_7002_entity",
"type": "progene_text",
"text": [
"tviA"
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"offsets": [
[
224,
228
]
],
"normalized": []
},
{
"id": "split_0_train_7003_entity",
"type": "progene_text",
"text": [
"vipR"
],
"offsets": [
[
231,
235
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4469
|
split_0_train_4469
|
[
{
"id": "split_0_train_4469_passage",
"type": "progene_text",
"text": [
"We further show the interaction of RcsAB with the rcsA promoters of various species , indicating that rcsA autoregulation also depends on the presence of both proteins ."
],
"offsets": [
[
0,
169
]
]
}
] |
[
{
"id": "split_0_train_7004_entity",
"type": "progene_text",
"text": [
"RcsAB"
],
"offsets": [
[
35,
40
]
],
"normalized": []
},
{
"id": "split_0_train_7005_entity",
"type": "progene_text",
"text": [
"rcsA"
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"offsets": [
[
50,
54
]
],
"normalized": []
},
{
"id": "split_0_train_7006_entity",
"type": "progene_text",
"text": [
"rcsA"
],
"offsets": [
[
102,
106
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4470
|
split_0_train_4470
|
[
{
"id": "split_0_train_4470_passage",
"type": "progene_text",
"text": [
"The compilation of all identified RcsAB binding sites revealed the conserved core sequence TaAGaatatTCctA , which we propose to be termed RcsAB box ."
],
"offsets": [
[
0,
149
]
]
}
] |
[
{
"id": "split_0_train_7007_entity",
"type": "progene_text",
"text": [
"RcsAB"
],
"offsets": [
[
34,
39
]
],
"normalized": []
},
{
"id": "split_0_train_7008_entity",
"type": "progene_text",
"text": [
"RcsAB"
],
"offsets": [
[
138,
143
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4471
|
split_0_train_4471
|
[
{
"id": "split_0_train_4471_passage",
"type": "progene_text",
"text": [
"The RcsAB box is also part of Bordetella pertussis BvgA binding sites and may represent a more distributed recognition motif within the LuxR superfamily of transcriptional regulators ."
],
"offsets": [
[
0,
184
]
]
}
] |
[
{
"id": "split_0_train_7009_entity",
"type": "progene_text",
"text": [
"RcsAB"
],
"offsets": [
[
4,
9
]
],
"normalized": []
},
{
"id": "split_0_train_7010_entity",
"type": "progene_text",
"text": [
"BvgA"
],
"offsets": [
[
51,
55
]
],
"normalized": []
},
{
"id": "split_0_train_7011_entity",
"type": "progene_text",
"text": [
"LuxR superfamily"
],
"offsets": [
[
136,
152
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4472
|
split_0_train_4472
|
[
{
"id": "split_0_train_4472_passage",
"type": "progene_text",
"text": [
"The RcsAB box is essential for the induction of Rcs - regulated promoters ."
],
"offsets": [
[
0,
75
]
]
}
] |
[
{
"id": "split_0_train_7012_entity",
"type": "progene_text",
"text": [
"RcsAB"
],
"offsets": [
[
4,
9
]
],
"normalized": []
},
{
"id": "split_0_train_7013_entity",
"type": "progene_text",
"text": [
"Rcs"
],
"offsets": [
[
48,
51
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4473
|
split_0_train_4473
|
[
{
"id": "split_0_train_4473_passage",
"type": "progene_text",
"text": [
"Site - specific mutations of conserved nucleotides in the RcsAB boxes of the E. coli wza and rcsA promoters resulted in an exopolysaccharide - negative phenotype and in the reduction of reporter gene expression ."
],
"offsets": [
[
0,
212
]
]
}
] |
[
{
"id": "split_0_train_7014_entity",
"type": "progene_text",
"text": [
"RcsAB"
],
"offsets": [
[
58,
63
]
],
"normalized": []
},
{
"id": "split_0_train_7015_entity",
"type": "progene_text",
"text": [
"wza"
],
"offsets": [
[
85,
88
]
],
"normalized": []
},
{
"id": "split_0_train_7016_entity",
"type": "progene_text",
"text": [
"rcsA"
],
"offsets": [
[
93,
97
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4474
|
split_0_train_4474
|
[
{
"id": "split_0_train_4474_passage",
"type": "progene_text",
"text": [
"TrkA amino acids controlling specificity for nerve growth factor ."
],
"offsets": [
[
0,
66
]
]
}
] |
[
{
"id": "split_0_train_7017_entity",
"type": "progene_text",
"text": [
"TrkA"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_7018_entity",
"type": "progene_text",
"text": [
"nerve growth factor"
],
"offsets": [
[
45,
64
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4475
|
split_0_train_4475
|
[
{
"id": "split_0_train_4475_passage",
"type": "progene_text",
"text": [
"Neurotrophins are important for the development and maintenance of the vertebrate nervous system , mediating their signal into the cell by specific interaction with tyrosine kinase receptors of the Trk family ."
],
"offsets": [
[
0,
210
]
]
}
] |
[
{
"id": "split_0_train_7019_entity",
"type": "progene_text",
"text": [
"Neurotrophins"
],
"offsets": [
[
0,
13
]
],
"normalized": []
},
{
"id": "split_0_train_7020_entity",
"type": "progene_text",
"text": [
"tyrosine kinase receptors"
],
"offsets": [
[
165,
190
]
],
"normalized": []
},
{
"id": "split_0_train_7021_entity",
"type": "progene_text",
"text": [
"Trk family"
],
"offsets": [
[
198,
208
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4476
|
split_0_train_4476
|
[
{
"id": "split_0_train_4476_passage",
"type": "progene_text",
"text": [
"The extracellular portion of the Trk receptors has been previously proposed to consist of a cysteine - rich motif , a leucine - rich motif , a second cysteine - rich motif followed by two immunoglobulin - like domains ."
],
"offsets": [
[
0,
219
]
]
}
] |
[
{
"id": "split_0_train_7022_entity",
"type": "progene_text",
"text": [
"Trk"
],
"offsets": [
[
33,
36
]
],
"normalized": []
},
{
"id": "split_0_train_7023_entity",
"type": "progene_text",
"text": [
"immunoglobulin"
],
"offsets": [
[
188,
202
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4477
|
split_0_train_4477
|
[
{
"id": "split_0_train_4477_passage",
"type": "progene_text",
"text": [
"Earlier studies have shown that a major neurotrophin - binding site in the Trk receptors resides in the second immunoglobulin - like domain ."
],
"offsets": [
[
0,
141
]
]
}
] |
[
{
"id": "split_0_train_7024_entity",
"type": "progene_text",
"text": [
"neurotrophin"
],
"offsets": [
[
40,
52
]
],
"normalized": []
},
{
"id": "split_0_train_7025_entity",
"type": "progene_text",
"text": [
"Trk"
],
"offsets": [
[
75,
78
]
],
"normalized": []
},
{
"id": "split_0_train_7026_entity",
"type": "progene_text",
"text": [
"immunoglobulin"
],
"offsets": [
[
111,
125
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4478
|
split_0_train_4478
|
[
{
"id": "split_0_train_4478_passage",
"type": "progene_text",
"text": [
"Although the individual amino acids in TrkA involved in binding to nerve growth factor ( NGF ) and those in TrkC involved in binding to neurotrophin-3 have been mapped in this domain , the Trk amino acids that provide specificity remained unclear ."
],
"offsets": [
[
0,
248
]
]
}
] |
[
{
"id": "split_0_train_7027_entity",
"type": "progene_text",
"text": [
"TrkA"
],
"offsets": [
[
39,
43
]
],
"normalized": []
},
{
"id": "split_0_train_7028_entity",
"type": "progene_text",
"text": [
"nerve growth factor"
],
"offsets": [
[
67,
86
]
],
"normalized": []
},
{
"id": "split_0_train_7029_entity",
"type": "progene_text",
"text": [
"NGF"
],
"offsets": [
[
89,
92
]
],
"normalized": []
},
{
"id": "split_0_train_7030_entity",
"type": "progene_text",
"text": [
"TrkC"
],
"offsets": [
[
108,
112
]
],
"normalized": []
},
{
"id": "split_0_train_7031_entity",
"type": "progene_text",
"text": [
"neurotrophin-3"
],
"offsets": [
[
136,
150
]
],
"normalized": []
},
{
"id": "split_0_train_7032_entity",
"type": "progene_text",
"text": [
"Trk"
],
"offsets": [
[
189,
192
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4479
|
split_0_train_4479
|
[
{
"id": "split_0_train_4479_passage",
"type": "progene_text",
"text": [
"In this study , a minimum set of residues in the human TrkC second immunoglobulin - like domain , which does not bind nerve growth factor ( NGF ) , were substituted with those from human TrkA ."
],
"offsets": [
[
0,
193
]
]
}
] |
[
{
"id": "split_0_train_7033_entity",
"type": "progene_text",
"text": [
"TrkC"
],
"offsets": [
[
55,
59
]
],
"normalized": []
},
{
"id": "split_0_train_7034_entity",
"type": "progene_text",
"text": [
"NGF"
],
"offsets": [
[
140,
143
]
],
"normalized": []
},
{
"id": "split_0_train_7035_entity",
"type": "progene_text",
"text": [
"TrkA"
],
"offsets": [
[
187,
191
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4480
|
split_0_train_4480
|
[
{
"id": "split_0_train_4480_passage",
"type": "progene_text",
"text": [
"The resulting Trk variant recruited binding of NGF equivalent to TrkA , maintained neurotrophin - 3 binding equivalent to TrkC , and also bound brain - derived neurotrophin , although with lower affinity compared with TrkB ."
],
"offsets": [
[
0,
224
]
]
}
] |
[
{
"id": "split_0_train_7036_entity",
"type": "progene_text",
"text": [
"Trk"
],
"offsets": [
[
14,
17
]
],
"normalized": []
},
{
"id": "split_0_train_7037_entity",
"type": "progene_text",
"text": [
"NGF"
],
"offsets": [
[
47,
50
]
],
"normalized": []
},
{
"id": "split_0_train_7038_entity",
"type": "progene_text",
"text": [
"TrkA"
],
"offsets": [
[
65,
69
]
],
"normalized": []
},
{
"id": "split_0_train_7039_entity",
"type": "progene_text",
"text": [
"neurotrophin - 3"
],
"offsets": [
[
83,
99
]
],
"normalized": []
},
{
"id": "split_0_train_7040_entity",
"type": "progene_text",
"text": [
"TrkC"
],
"offsets": [
[
122,
126
]
],
"normalized": []
},
{
"id": "split_0_train_7041_entity",
"type": "progene_text",
"text": [
"brain - derived neurotrophin"
],
"offsets": [
[
144,
172
]
],
"normalized": []
},
{
"id": "split_0_train_7042_entity",
"type": "progene_text",
"text": [
"TrkB"
],
"offsets": [
[
218,
222
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4481
|
split_0_train_4481
|
[
{
"id": "split_0_train_4481_passage",
"type": "progene_text",
"text": [
"This implies that the amino acids in the second immunoglobulin - like domain that determine Trk specificity are distinct for each Trk ."
],
"offsets": [
[
0,
135
]
]
}
] |
[
{
"id": "split_0_train_7043_entity",
"type": "progene_text",
"text": [
"immunoglobulin"
],
"offsets": [
[
48,
62
]
],
"normalized": []
},
{
"id": "split_0_train_7044_entity",
"type": "progene_text",
"text": [
"Trk"
],
"offsets": [
[
92,
95
]
],
"normalized": []
},
{
"id": "split_0_train_7045_entity",
"type": "progene_text",
"text": [
"Trk"
],
"offsets": [
[
130,
133
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4482
|
split_0_train_4482
|
[
{
"id": "split_0_train_4482_passage",
"type": "progene_text",
"text": [
"Recombinant expression and neutralizing activity of an MHC class II binding epitope of toxic shock syndrome toxin-1 ."
],
"offsets": [
[
0,
117
]
]
}
] |
[
{
"id": "split_0_train_7046_entity",
"type": "progene_text",
"text": [
"MHC class II"
],
"offsets": [
[
55,
67
]
],
"normalized": []
},
{
"id": "split_0_train_7047_entity",
"type": "progene_text",
"text": [
"toxic shock syndrome toxin-1"
],
"offsets": [
[
87,
115
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4483
|
split_0_train_4483
|
[
{
"id": "split_0_train_4483_passage",
"type": "progene_text",
"text": [
"Toxic shock syndrome ( TSS ) is caused by the staphylococcal superantigen , TSST-1 ."
],
"offsets": [
[
0,
84
]
]
}
] |
[
{
"id": "split_0_train_7048_entity",
"type": "progene_text",
"text": [
"superantigen"
],
"offsets": [
[
61,
73
]
],
"normalized": []
},
{
"id": "split_0_train_7049_entity",
"type": "progene_text",
"text": [
"TSST-1"
],
"offsets": [
[
76,
82
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4484
|
split_0_train_4484
|
[
{
"id": "split_0_train_4484_passage",
"type": "progene_text",
"text": [
"The MHC class II binding domain of TSST-1 containing a conserved sequence with other related staphylococcal enterotoxins , comprising TSST - 1 residues 47 - 64 [ ( T(47-64 ) ] , was expressed as a fusion protein with either glutathione - S - transferase ( GST ( 47 - 64 ) ) , filamentous phage coat protein ( pIII ( 47 - 64 ) ) , or E. coli outer membrane porin protein ( OprF ( 47 - 64 ) ) , or synthesized as a peptide conjugated to bovine serum albumin , BSA ( 47 - 64 ) . GST ( 47 - 64 ) , OprF ( 47 - 64 ) and BSA ( 47 - 64 ) , but not pIII ( 47 - 64 ) , all induced high - titer T(47-64 ) - specific antibodies in Balb / c mice. However , only anti - GST ( 47-64 ) antibodies inhibited ( 125 ) I - TSST - 1 binding to MHC class II and abrogated TSST - 1 - induced T cell mitogenesis and TNFalpha secretion in human peripheral blood mononuclear cells ."
],
"offsets": [
[
0,
857
]
]
}
] |
[
{
"id": "split_0_train_7050_entity",
"type": "progene_text",
"text": [
"MHC class II"
],
"offsets": [
[
4,
16
]
],
"normalized": []
},
{
"id": "split_0_train_7051_entity",
"type": "progene_text",
"text": [
"TSST-1"
],
"offsets": [
[
35,
41
]
],
"normalized": []
},
{
"id": "split_0_train_7052_entity",
"type": "progene_text",
"text": [
"TSST - 1"
],
"offsets": [
[
134,
142
]
],
"normalized": []
},
{
"id": "split_0_train_7053_entity",
"type": "progene_text",
"text": [
"glutathione - S - transferase"
],
"offsets": [
[
224,
253
]
],
"normalized": []
},
{
"id": "split_0_train_7054_entity",
"type": "progene_text",
"text": [
"GST"
],
"offsets": [
[
256,
259
]
],
"normalized": []
},
{
"id": "split_0_train_7055_entity",
"type": "progene_text",
"text": [
"coat protein"
],
"offsets": [
[
294,
306
]
],
"normalized": []
},
{
"id": "split_0_train_7056_entity",
"type": "progene_text",
"text": [
"porin"
],
"offsets": [
[
356,
361
]
],
"normalized": []
},
{
"id": "split_0_train_7057_entity",
"type": "progene_text",
"text": [
"OprF"
],
"offsets": [
[
372,
376
]
],
"normalized": []
},
{
"id": "split_0_train_7058_entity",
"type": "progene_text",
"text": [
"serum albumin"
],
"offsets": [
[
442,
455
]
],
"normalized": []
},
{
"id": "split_0_train_7059_entity",
"type": "progene_text",
"text": [
"BSA"
],
"offsets": [
[
458,
461
]
],
"normalized": []
},
{
"id": "split_0_train_7060_entity",
"type": "progene_text",
"text": [
"GST"
],
"offsets": [
[
476,
479
]
],
"normalized": []
},
{
"id": "split_0_train_7061_entity",
"type": "progene_text",
"text": [
"OprF"
],
"offsets": [
[
494,
498
]
],
"normalized": []
},
{
"id": "split_0_train_7062_entity",
"type": "progene_text",
"text": [
"BSA"
],
"offsets": [
[
515,
518
]
],
"normalized": []
},
{
"id": "split_0_train_7063_entity",
"type": "progene_text",
"text": [
"GST"
],
"offsets": [
[
657,
660
]
],
"normalized": []
},
{
"id": "split_0_train_7064_entity",
"type": "progene_text",
"text": [
"TSST - 1"
],
"offsets": [
[
704,
712
]
],
"normalized": []
},
{
"id": "split_0_train_7065_entity",
"type": "progene_text",
"text": [
"MHC class II"
],
"offsets": [
[
724,
736
]
],
"normalized": []
},
{
"id": "split_0_train_7066_entity",
"type": "progene_text",
"text": [
"TSST - 1"
],
"offsets": [
[
751,
759
]
],
"normalized": []
},
{
"id": "split_0_train_7067_entity",
"type": "progene_text",
"text": [
"TNFalpha"
],
"offsets": [
[
793,
801
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4485
|
split_0_train_4485
|
[
{
"id": "split_0_train_4485_passage",
"type": "progene_text",
"text": [
"Purified GST ( 47-64 ) also inhibited ( 125 ) I - TSST - 1 binding in a dose - dependent manner ."
],
"offsets": [
[
0,
97
]
]
}
] |
[
{
"id": "split_0_train_7068_entity",
"type": "progene_text",
"text": [
"GST"
],
"offsets": [
[
9,
12
]
],
"normalized": []
},
{
"id": "split_0_train_7069_entity",
"type": "progene_text",
"text": [
"TSST - 1"
],
"offsets": [
[
50,
58
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4486
|
split_0_train_4486
|
[
{
"id": "split_0_train_4486_passage",
"type": "progene_text",
"text": [
"These findings suggest that GST ( 47-64 ) may have potential as a recombinant peptide vaccine or TSST - 1 receptor inhibitor against TSS ."
],
"offsets": [
[
0,
138
]
]
}
] |
[
{
"id": "split_0_train_7070_entity",
"type": "progene_text",
"text": [
"GST"
],
"offsets": [
[
28,
31
]
],
"normalized": []
},
{
"id": "split_0_train_7071_entity",
"type": "progene_text",
"text": [
"TSST - 1"
],
"offsets": [
[
97,
105
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4487
|
split_0_train_4487
|
[
{
"id": "split_0_train_4487_passage",
"type": "progene_text",
"text": [
"Choline plus cytidine stimulate phospholipid production , and the expression and secretion of amyloid precursor protein in rat PC12 cells ."
],
"offsets": [
[
0,
139
]
]
}
] |
[
{
"id": "split_0_train_7072_entity",
"type": "progene_text",
"text": [
"amyloid precursor protein"
],
"offsets": [
[
94,
119
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4488
|
split_0_train_4488
|
[
{
"id": "split_0_train_4488_passage",
"type": "progene_text",
"text": [
"The amyloid precursor protein ( APP ) is a transmembrane protein anchored in the membrane lipid bilayer ."
],
"offsets": [
[
0,
105
]
]
}
] |
[
{
"id": "split_0_train_7073_entity",
"type": "progene_text",
"text": [
"amyloid precursor protein"
],
"offsets": [
[
4,
29
]
],
"normalized": []
},
{
"id": "split_0_train_7074_entity",
"type": "progene_text",
"text": [
"APP"
],
"offsets": [
[
32,
35
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4489
|
split_0_train_4489
|
[
{
"id": "split_0_train_4489_passage",
"type": "progene_text",
"text": [
"Choline and cytidine are major precursors of cell membranes , and are regulatory elements in membrane biosynthesis ."
],
"offsets": [
[
0,
116
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4490
|
split_0_train_4490
|
[
{
"id": "split_0_train_4490_passage",
"type": "progene_text",
"text": [
"We examined the levels of cellular APP holoprotein and secreted APPs when rat PC12 cells are stimulated to undergo increase in membrane phospholipids by choline + cytidine ( 2+2,5+5,10+10 or 50 + 50 microM ) treatment ."
],
"offsets": [
[
0,
219
]
]
}
] |
[
{
"id": "split_0_train_7075_entity",
"type": "progene_text",
"text": [
"APP"
],
"offsets": [
[
35,
38
]
],
"normalized": []
},
{
"id": "split_0_train_7076_entity",
"type": "progene_text",
"text": [
"APPs"
],
"offsets": [
[
64,
68
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4491
|
split_0_train_4491
|
[
{
"id": "split_0_train_4491_passage",
"type": "progene_text",
"text": [
"We now show that as phospholipids levels are increased by supplemental choline and cytidine treatment , the levels of cell - associated APP also rise stoichiometrically ; these treatments also caused major ( up to 6. 8 - fold ) increases in the amounts of secreted APP released into the cell medium , and also stimulated increased process formation ."
],
"offsets": [
[
0,
350
]
]
}
] |
[
{
"id": "split_0_train_7077_entity",
"type": "progene_text",
"text": [
"APP"
],
"offsets": [
[
136,
139
]
],
"normalized": []
},
{
"id": "split_0_train_7078_entity",
"type": "progene_text",
"text": [
"APP"
],
"offsets": [
[
265,
268
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4492
|
split_0_train_4492
|
[
{
"id": "split_0_train_4492_passage",
"type": "progene_text",
"text": [
"These results show that choline plus cytidine increase both phospholipid levels , and the expression and secretion in PC12 cells ."
],
"offsets": [
[
0,
130
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4493
|
split_0_train_4493
|
[
{
"id": "split_0_train_4493_passage",
"type": "progene_text",
"text": [
"It appears that agents that stimulate cellular membrane biosynthesis may be used to stimulate the secretion of neurotrophic APPs and neurite formation in neurodegenerative disorders such as Alzheimer 's disease ."
],
"offsets": [
[
0,
212
]
]
}
] |
[
{
"id": "split_0_train_7079_entity",
"type": "progene_text",
"text": [
"APPs"
],
"offsets": [
[
124,
128
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4494
|
split_0_train_4494
|
[
{
"id": "split_0_train_4494_passage",
"type": "progene_text",
"text": [
"The motif for peptide binding to the insulin - dependent diabetes mellitus - associated class II MHC molecule I-Ag7 validated by phage display library ."
],
"offsets": [
[
0,
152
]
]
}
] |
[
{
"id": "split_0_train_7080_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
37,
44
]
],
"normalized": []
},
{
"id": "split_0_train_7081_entity",
"type": "progene_text",
"text": [
"class II MHC"
],
"offsets": [
[
88,
100
]
],
"normalized": []
},
{
"id": "split_0_train_7082_entity",
"type": "progene_text",
"text": [
"I-Ag7"
],
"offsets": [
[
110,
115
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4495
|
split_0_train_4495
|
[
{
"id": "split_0_train_4495_passage",
"type": "progene_text",
"text": [
"The MHC class II molecule I-Ag7 is essential for the development of insulin - dependent diabetes mellitus ( IDDM ) in the non - obese diabetic ( NOD ) mouse but the requirements for peptide binding to I - Ag7 are still controversial ."
],
"offsets": [
[
0,
234
]
]
}
] |
[
{
"id": "split_0_train_7083_entity",
"type": "progene_text",
"text": [
"MHC class II"
],
"offsets": [
[
4,
16
]
],
"normalized": []
},
{
"id": "split_0_train_7084_entity",
"type": "progene_text",
"text": [
"I-Ag7"
],
"offsets": [
[
26,
31
]
],
"normalized": []
},
{
"id": "split_0_train_7085_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
68,
75
]
],
"normalized": []
},
{
"id": "split_0_train_7086_entity",
"type": "progene_text",
"text": [
"I - Ag7"
],
"offsets": [
[
201,
208
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4496
|
split_0_train_4496
|
[
{
"id": "split_0_train_4496_passage",
"type": "progene_text",
"text": [
"We have now isolated I-Ag7 - binding phage from a large phage display library encoding random nonamer peptides ."
],
"offsets": [
[
0,
112
]
]
}
] |
[
{
"id": "split_0_train_7087_entity",
"type": "progene_text",
"text": [
"I-Ag7"
],
"offsets": [
[
21,
26
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4497
|
split_0_train_4497
|
[
{
"id": "split_0_train_4497_passage",
"type": "progene_text",
"text": [
"Ninety peptide - encoding regions of phage eluted from I - Ag7 were sequenced and > 75 % of the corresponding synthetic peptides bound to I - Ag7 ."
],
"offsets": [
[
0,
147
]
]
}
] |
[
{
"id": "split_0_train_7088_entity",
"type": "progene_text",
"text": [
"I - Ag7"
],
"offsets": [
[
55,
62
]
],
"normalized": []
},
{
"id": "split_0_train_7089_entity",
"type": "progene_text",
"text": [
"I - Ag7"
],
"offsets": [
[
138,
145
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4498
|
split_0_train_4498
|
[
{
"id": "split_0_train_4498_passage",
"type": "progene_text",
"text": [
"Peptide alignment led to the identification of position - specific anchor residues ."
],
"offsets": [
[
0,
84
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4499
|
split_0_train_4499
|
[
{
"id": "split_0_train_4499_passage",
"type": "progene_text",
"text": [
"Hydrophobic ( V and P ) and positively charged ( K ) residues were highly enriched at P6 and positively charged ( R and K) , aromatic ( Y ) or hydrophobic ( L ) residues at P9 ."
],
"offsets": [
[
0,
177
]
]
}
] |
[] |
[] |
[] |
[] |
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