id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_4300
|
split_0_train_4300
|
[
{
"id": "split_0_train_4300_passage",
"type": "progene_text",
"text": [
"The AL-R8 SI ( sealed insert ) is the next generation staging container for plutonium pits at the U.S. DOE Pantex Plant ."
],
"offsets": [
[
0,
121
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4301
|
split_0_train_4301
|
[
{
"id": "split_0_train_4301_passage",
"type": "progene_text",
"text": [
"The sealed insert is a stainless steel container that will be placed inside a modified AL-R8 container to stagepits ."
],
"offsets": [
[
0,
117
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4302
|
split_0_train_4302
|
[
{
"id": "split_0_train_4302_passage",
"type": "progene_text",
"text": [
"A pit is a hollow sphere of plutonium metal which is the primary fissionable material in nuclear weapons ( warheads and bombs ) ."
],
"offsets": [
[
0,
129
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4303
|
split_0_train_4303
|
[
{
"id": "split_0_train_4303_passage",
"type": "progene_text",
"text": [
"It is hermetically sealed by a cladding material , which is usually stainless steel ."
],
"offsets": [
[
0,
85
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4304
|
split_0_train_4304
|
[
{
"id": "split_0_train_4304_passage",
"type": "progene_text",
"text": [
"Personnel exposures to ionizing radiation from the pits in storage are expected to decrease due to the attenuation provided by the new SI ."
],
"offsets": [
[
0,
139
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4305
|
split_0_train_4305
|
[
{
"id": "split_0_train_4305_passage",
"type": "progene_text",
"text": [
"All personnel exposures to ionizing radiation at Pantex Plant are As Low As Reasonably Achievable ( ALARA ) ."
],
"offsets": [
[
0,
109
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4306
|
split_0_train_4306
|
[
{
"id": "split_0_train_4306_passage",
"type": "progene_text",
"text": [
"Pantex Plant secures the common defense and national security of the United States by safely staging plutonium pits in a manner that protects the health and safety of employees , the public , and the environment ."
],
"offsets": [
[
0,
213
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4307
|
split_0_train_4307
|
[
{
"id": "split_0_train_4307_passage",
"type": "progene_text",
"text": [
"Molecular cloning and characterization of a novel repeat - containing Leishmania major gene , ppg1 , that encodes a membrane - associated form of proteophosphoglycan with a putative glycosylphosphatidylinositol anchor ."
],
"offsets": [
[
0,
219
]
]
}
] |
[
{
"id": "split_0_train_6709_entity",
"type": "progene_text",
"text": [
"ppg1"
],
"offsets": [
[
94,
98
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4308
|
split_0_train_4308
|
[
{
"id": "split_0_train_4308_passage",
"type": "progene_text",
"text": [
"Leishmania parasites secrete a variety of proteins that are modified by phosphoglycan chains structurally similar to those of the cell surface glycolipid lipophosphoglycan ."
],
"offsets": [
[
0,
173
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4309
|
split_0_train_4309
|
[
{
"id": "split_0_train_4309_passage",
"type": "progene_text",
"text": [
"These proteins are collectively called proteophosphoglycans ."
],
"offsets": [
[
0,
61
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4310
|
split_0_train_4310
|
[
{
"id": "split_0_train_4310_passage",
"type": "progene_text",
"text": [
"We report here the cloning and sequencing of a novel Leishmania major proteophosphoglycan gene , ppg1 ."
],
"offsets": [
[
0,
103
]
]
}
] |
[
{
"id": "split_0_train_6710_entity",
"type": "progene_text",
"text": [
"ppg1"
],
"offsets": [
[
97,
101
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4311
|
split_0_train_4311
|
[
{
"id": "split_0_train_4311_passage",
"type": "progene_text",
"text": [
"It encodes a large polypeptide of approximately 2300 amino acids ."
],
"offsets": [
[
0,
66
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4312
|
split_0_train_4312
|
[
{
"id": "split_0_train_4312_passage",
"type": "progene_text",
"text": [
"The N - terminal domain of approximately 70 kDa exhibits 11 imperfect amino acid repeats that show some homology to promastigote surface glycoproteins of the psa2 / gp46 complex ."
],
"offsets": [
[
0,
179
]
]
}
] |
[
{
"id": "split_0_train_6711_entity",
"type": "progene_text",
"text": [
"psa2"
],
"offsets": [
[
158,
162
]
],
"normalized": []
},
{
"id": "split_0_train_6712_entity",
"type": "progene_text",
"text": [
"gp46"
],
"offsets": [
[
165,
169
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4313
|
split_0_train_4313
|
[
{
"id": "split_0_train_4313_passage",
"type": "progene_text",
"text": [
"The large central domain apparently consists exclusively of approximately 100 repetitive peptides of the sequence APSASSSSA ( P/S ) SSSSS ( +/-S) ."
],
"offsets": [
[
0,
147
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4314
|
split_0_train_4314
|
[
{
"id": "split_0_train_4314_passage",
"type": "progene_text",
"text": [
"Gene fusion experiments demonstrate that these peptide repeats are the targets of phosphoglycosylation in Leishmania and that they form extended filamentous structures reminiscent of mammalian mucins ."
],
"offsets": [
[
0,
201
]
]
}
] |
[
{
"id": "split_0_train_6713_entity",
"type": "progene_text",
"text": [
"mucins"
],
"offsets": [
[
193,
199
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4315
|
split_0_train_4315
|
[
{
"id": "split_0_train_4315_passage",
"type": "progene_text",
"text": [
"The C - terminal domain contains a functional glycosylphosphatidylinositol anchor addition signal sequence , which confers cell surface localization to a normally secreted Leishmania acid phosphatase , when fused to its C terminus ."
],
"offsets": [
[
0,
232
]
]
}
] |
[
{
"id": "split_0_train_6714_entity",
"type": "progene_text",
"text": [
"acid phosphatase"
],
"offsets": [
[
183,
199
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4316
|
split_0_train_4316
|
[
{
"id": "split_0_train_4316_passage",
"type": "progene_text",
"text": [
"Antibody binding studies show that the ppg1 gene product is phosphoglycosylated by phosphoglycan repeats and cap oligosaccharides ."
],
"offsets": [
[
0,
131
]
]
}
] |
[
{
"id": "split_0_train_6715_entity",
"type": "progene_text",
"text": [
"ppg1"
],
"offsets": [
[
39,
43
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4317
|
split_0_train_4317
|
[
{
"id": "split_0_train_4317_passage",
"type": "progene_text",
"text": [
"In contrast to previously characterized proteophosphoglycans , the ppg1 gene product is predominantly membrane - associated and it is expressed on the promastigote cell surface ."
],
"offsets": [
[
0,
178
]
]
}
] |
[
{
"id": "split_0_train_6716_entity",
"type": "progene_text",
"text": [
"ppg1"
],
"offsets": [
[
67,
71
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4318
|
split_0_train_4318
|
[
{
"id": "split_0_train_4318_passage",
"type": "progene_text",
"text": [
"Therefore this membrane - bound proteophosphoglycan may be important for direct host - parasite interactions ."
],
"offsets": [
[
0,
110
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4319
|
split_0_train_4319
|
[
{
"id": "split_0_train_4319_passage",
"type": "progene_text",
"text": [
"Resting metabolic rate and thermic effects of a sucrose - sweetened soft drink during the menstrual cycle in young Chinese women ."
],
"offsets": [
[
0,
130
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4320
|
split_0_train_4320
|
[
{
"id": "split_0_train_4320_passage",
"type": "progene_text",
"text": [
"The resting metabolic rate ( RMR ) and thermic effects ( TEF ) of a sucrose - sweetened soft drink in a group ( n = 19 ) of ovulating young Chinese women were determined by indirect calorimetry in the midfollicular and midluteal phases of the menstrual cycle ."
],
"offsets": [
[
0,
260
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4321
|
split_0_train_4321
|
[
{
"id": "split_0_train_4321_passage",
"type": "progene_text",
"text": [
"Urinary luteinizing hormone surge was used to confirm ovulation ."
],
"offsets": [
[
0,
65
]
]
}
] |
[
{
"id": "split_0_train_6717_entity",
"type": "progene_text",
"text": [
"luteinizing hormone"
],
"offsets": [
[
8,
27
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4322
|
split_0_train_4322
|
[
{
"id": "split_0_train_4322_passage",
"type": "progene_text",
"text": [
"The RMR was measured twice in each phase and found to be similar ( F(1,18 ) = 0.863 ) across the follicular ( 5018 kJ / 24 h ) and the luteal ( 5098 kJ / 24 h ) phases ."
],
"offsets": [
[
0,
169
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4323
|
split_0_train_4323
|
[
{
"id": "split_0_train_4323_passage",
"type": "progene_text",
"text": [
"Within each phase and on separate days , subjects were given water ( 280 mL ) or sucrose - sweetened soft drink ( 539 kJ ) ."
],
"offsets": [
[
0,
124
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4324
|
split_0_train_4324
|
[
{
"id": "split_0_train_4324_passage",
"type": "progene_text",
"text": [
"Soft drink , but not water , consumption increased energy expenditure over a period of 45 min ."
],
"offsets": [
[
0,
95
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4325
|
split_0_train_4325
|
[
{
"id": "split_0_train_4325_passage",
"type": "progene_text",
"text": [
"Compared with the follicular phase , a small but significant increase in TEF ( kJ / 45 min ) was observed in the luteal phase ( t = 2.434 , p < 0.05 ) ."
],
"offsets": [
[
0,
152
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4326
|
split_0_train_4326
|
[
{
"id": "split_0_train_4326_passage",
"type": "progene_text",
"text": [
"Energy expenditure after drinking the soft drink , however , was similar in the two phases ."
],
"offsets": [
[
0,
92
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4327
|
split_0_train_4327
|
[
{
"id": "split_0_train_4327_passage",
"type": "progene_text",
"text": [
"RMR was positively correlated with TEF ( r = 0.613 , p < 0.01 ) and net TEF ( r = 0.648 , p < 0.005 ) in the luteal but not the follicular phase ."
],
"offsets": [
[
0,
146
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4328
|
split_0_train_4328
|
[
{
"id": "split_0_train_4328_passage",
"type": "progene_text",
"text": [
"In ovulating women , the thermic effect of sucrose is influenced by the phase of the menstrual cycle ."
],
"offsets": [
[
0,
102
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4329
|
split_0_train_4329
|
[
{
"id": "split_0_train_4329_passage",
"type": "progene_text",
"text": [
"Functional evidence for a role of combined CDKN2A ( p16 - p14(ARF) ) / CDKN2B ( p15 ) gene inactivation in malignant gliomas ."
],
"offsets": [
[
0,
126
]
]
}
] |
[
{
"id": "split_0_train_6718_entity",
"type": "progene_text",
"text": [
"CDKN2A"
],
"offsets": [
[
43,
49
]
],
"normalized": []
},
{
"id": "split_0_train_6719_entity",
"type": "progene_text",
"text": [
"p16"
],
"offsets": [
[
52,
55
]
],
"normalized": []
},
{
"id": "split_0_train_6720_entity",
"type": "progene_text",
"text": [
"p14(ARF)"
],
"offsets": [
[
58,
66
]
],
"normalized": []
},
{
"id": "split_0_train_6721_entity",
"type": "progene_text",
"text": [
"CDKN2B"
],
"offsets": [
[
71,
77
]
],
"normalized": []
},
{
"id": "split_0_train_6722_entity",
"type": "progene_text",
"text": [
"p15"
],
"offsets": [
[
80,
83
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4330
|
split_0_train_4330
|
[
{
"id": "split_0_train_4330_passage",
"type": "progene_text",
"text": [
"Homozygous chromosome 9p deletions in gliomas commonly include the CDKN2A and CDKN2B genes , which code for the structurally highly homologous cdk inhibitors / tumor suppressors p16 and p15 , respectively ."
],
"offsets": [
[
0,
206
]
]
}
] |
[
{
"id": "split_0_train_6723_entity",
"type": "progene_text",
"text": [
"CDKN2A"
],
"offsets": [
[
67,
73
]
],
"normalized": []
},
{
"id": "split_0_train_6724_entity",
"type": "progene_text",
"text": [
"CDKN2B"
],
"offsets": [
[
78,
84
]
],
"normalized": []
},
{
"id": "split_0_train_6725_entity",
"type": "progene_text",
"text": [
"cdk inhibitors"
],
"offsets": [
[
143,
157
]
],
"normalized": []
},
{
"id": "split_0_train_6726_entity",
"type": "progene_text",
"text": [
"p16"
],
"offsets": [
[
178,
181
]
],
"normalized": []
},
{
"id": "split_0_train_6727_entity",
"type": "progene_text",
"text": [
"p15"
],
"offsets": [
[
186,
189
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4331
|
split_0_train_4331
|
[
{
"id": "split_0_train_4331_passage",
"type": "progene_text",
"text": [
"Alternative splicing of the CDKN2A gene results in the expression of p14 ( ARF ) ."
],
"offsets": [
[
0,
82
]
]
}
] |
[
{
"id": "split_0_train_6728_entity",
"type": "progene_text",
"text": [
"CDKN2A"
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"offsets": [
[
28,
34
]
],
"normalized": []
},
{
"id": "split_0_train_6729_entity",
"type": "progene_text",
"text": [
"p14 ( ARF )"
],
"offsets": [
[
69,
80
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4332
|
split_0_train_4332
|
[
{
"id": "split_0_train_4332_passage",
"type": "progene_text",
"text": [
"Interestingly , not only p16 and p15 , but also the structurally unrelated p14 ( ARF ) appear to function as negative cell cycle regulators ."
],
"offsets": [
[
0,
141
]
]
}
] |
[
{
"id": "split_0_train_6730_entity",
"type": "progene_text",
"text": [
"p16"
],
"offsets": [
[
25,
28
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],
"normalized": []
},
{
"id": "split_0_train_6731_entity",
"type": "progene_text",
"text": [
"p15"
],
"offsets": [
[
33,
36
]
],
"normalized": []
},
{
"id": "split_0_train_6732_entity",
"type": "progene_text",
"text": [
"p14 ( ARF )"
],
"offsets": [
[
75,
86
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4333
|
split_0_train_4333
|
[
{
"id": "split_0_train_4333_passage",
"type": "progene_text",
"text": [
"Concerted inactivation of p16 , p15 and p14 ( ARF ) could be demonstrated in seven of nine glioblastoma cell lines ."
],
"offsets": [
[
0,
116
]
]
}
] |
[
{
"id": "split_0_train_6733_entity",
"type": "progene_text",
"text": [
"p16"
],
"offsets": [
[
26,
29
]
],
"normalized": []
},
{
"id": "split_0_train_6734_entity",
"type": "progene_text",
"text": [
"p15"
],
"offsets": [
[
32,
35
]
],
"normalized": []
},
{
"id": "split_0_train_6735_entity",
"type": "progene_text",
"text": [
"p14 ( ARF )"
],
"offsets": [
[
40,
51
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4334
|
split_0_train_4334
|
[
{
"id": "split_0_train_4334_passage",
"type": "progene_text",
"text": [
"Strong suppression of tumorigenicity after transfection with p16 and p15 alone or in combination was seen in cell lines containing neither endogenous p16 nor p15 but functional pRB ."
],
"offsets": [
[
0,
182
]
]
}
] |
[
{
"id": "split_0_train_6736_entity",
"type": "progene_text",
"text": [
"p16"
],
"offsets": [
[
61,
64
]
],
"normalized": []
},
{
"id": "split_0_train_6737_entity",
"type": "progene_text",
"text": [
"p15"
],
"offsets": [
[
69,
72
]
],
"normalized": []
},
{
"id": "split_0_train_6738_entity",
"type": "progene_text",
"text": [
"p16"
],
"offsets": [
[
150,
153
]
],
"normalized": []
},
{
"id": "split_0_train_6739_entity",
"type": "progene_text",
"text": [
"p15"
],
"offsets": [
[
158,
161
]
],
"normalized": []
},
{
"id": "split_0_train_6740_entity",
"type": "progene_text",
"text": [
"pRB"
],
"offsets": [
[
177,
180
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4335
|
split_0_train_4335
|
[
{
"id": "split_0_train_4335_passage",
"type": "progene_text",
"text": [
"Significantly weaker growth suppression was observed in tumors either retaining expression of both p16 and p15 or p15 only ."
],
"offsets": [
[
0,
124
]
]
}
] |
[
{
"id": "split_0_train_6741_entity",
"type": "progene_text",
"text": [
"p16"
],
"offsets": [
[
99,
102
]
],
"normalized": []
},
{
"id": "split_0_train_6742_entity",
"type": "progene_text",
"text": [
"p15"
],
"offsets": [
[
107,
110
]
],
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{
"id": "split_0_train_6743_entity",
"type": "progene_text",
"text": [
"p15"
],
"offsets": [
[
114,
117
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4336
|
split_0_train_4336
|
[
{
"id": "split_0_train_4336_passage",
"type": "progene_text",
"text": [
"p14 ( ARF ) proved to be a potent tumor suppressor in the presence of wild - type p53 , while mutant p53 substantially reduced growth inhibition by p14 ( ARF ) ."
],
"offsets": [
[
0,
161
]
]
}
] |
[
{
"id": "split_0_train_6744_entity",
"type": "progene_text",
"text": [
"p14 ( ARF )"
],
"offsets": [
[
0,
11
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],
"normalized": []
},
{
"id": "split_0_train_6745_entity",
"type": "progene_text",
"text": [
"p53"
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[
82,
85
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],
"normalized": []
},
{
"id": "split_0_train_6746_entity",
"type": "progene_text",
"text": [
"p53"
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101,
104
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],
"normalized": []
},
{
"id": "split_0_train_6747_entity",
"type": "progene_text",
"text": [
"p14 ( ARF )"
],
"offsets": [
[
148,
159
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4337
|
split_0_train_4337
|
[
{
"id": "split_0_train_4337_passage",
"type": "progene_text",
"text": [
"No differences between p16 and p15 effects could be observed , suggesting a largely overlapping function of p16 and p15 ."
],
"offsets": [
[
0,
121
]
]
}
] |
[
{
"id": "split_0_train_6748_entity",
"type": "progene_text",
"text": [
"p16"
],
"offsets": [
[
23,
26
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},
{
"id": "split_0_train_6749_entity",
"type": "progene_text",
"text": [
"p15"
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31,
34
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},
{
"id": "split_0_train_6750_entity",
"type": "progene_text",
"text": [
"p16"
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108,
111
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},
{
"id": "split_0_train_6751_entity",
"type": "progene_text",
"text": [
"p15"
],
"offsets": [
[
116,
119
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4338
|
split_0_train_4338
|
[
{
"id": "split_0_train_4338_passage",
"type": "progene_text",
"text": [
"To facilitate further research into p16 / p15 effects , three cell lines with conditional , tetracycline - controlled p16 expression were established ."
],
"offsets": [
[
0,
151
]
]
}
] |
[
{
"id": "split_0_train_6752_entity",
"type": "progene_text",
"text": [
"p16"
],
"offsets": [
[
36,
39
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],
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},
{
"id": "split_0_train_6753_entity",
"type": "progene_text",
"text": [
"p15"
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42,
45
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},
{
"id": "split_0_train_6754_entity",
"type": "progene_text",
"text": [
"p16"
],
"offsets": [
[
118,
121
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4339
|
split_0_train_4339
|
[
{
"id": "split_0_train_4339_passage",
"type": "progene_text",
"text": [
"Reversible growth suppression mediated by p16 was observed in these models ."
],
"offsets": [
[
0,
76
]
]
}
] |
[
{
"id": "split_0_train_6755_entity",
"type": "progene_text",
"text": [
"p16"
],
"offsets": [
[
42,
45
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4340
|
split_0_train_4340
|
[
{
"id": "split_0_train_4340_passage",
"type": "progene_text",
"text": [
"Combined inactivation of CDKN2A and CDKN2B , i.e. , loss of both p16 and p15 as well as p14(ARF) , results in disruption of two major growth control pathways involving pRB and p53 in malignant gliomas ."
],
"offsets": [
[
0,
202
]
]
}
] |
[
{
"id": "split_0_train_6756_entity",
"type": "progene_text",
"text": [
"CDKN2A"
],
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[
25,
31
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],
"normalized": []
},
{
"id": "split_0_train_6757_entity",
"type": "progene_text",
"text": [
"CDKN2B"
],
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36,
42
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],
"normalized": []
},
{
"id": "split_0_train_6758_entity",
"type": "progene_text",
"text": [
"p16"
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65,
68
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],
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},
{
"id": "split_0_train_6759_entity",
"type": "progene_text",
"text": [
"p15"
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73,
76
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],
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},
{
"id": "split_0_train_6760_entity",
"type": "progene_text",
"text": [
"p14(ARF)"
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[
88,
96
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],
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},
{
"id": "split_0_train_6761_entity",
"type": "progene_text",
"text": [
"pRB"
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[
168,
171
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],
"normalized": []
},
{
"id": "split_0_train_6762_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
176,
179
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4341
|
split_0_train_4341
|
[
{
"id": "split_0_train_4341_passage",
"type": "progene_text",
"text": [
"Therefore , homozygous co - deletions of CDKN2A and CDKN2B rather than mutations targeting individual transcripts are frequently selected for in these tumors ."
],
"offsets": [
[
0,
159
]
]
}
] |
[
{
"id": "split_0_train_6763_entity",
"type": "progene_text",
"text": [
"CDKN2A"
],
"offsets": [
[
41,
47
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],
"normalized": []
},
{
"id": "split_0_train_6764_entity",
"type": "progene_text",
"text": [
"CDKN2B"
],
"offsets": [
[
52,
58
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4342
|
split_0_train_4342
|
[
{
"id": "split_0_train_4342_passage",
"type": "progene_text",
"text": [
"E1A + cHa-ras transformed rat embryo fibroblast cells are characterized by high and constitutive DNA binding activities of AP-1 dimers with significantly altered composition ."
],
"offsets": [
[
0,
175
]
]
}
] |
[
{
"id": "split_0_train_6765_entity",
"type": "progene_text",
"text": [
"E1A"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_6766_entity",
"type": "progene_text",
"text": [
"cHa-ras"
],
"offsets": [
[
6,
13
]
],
"normalized": []
},
{
"id": "split_0_train_6767_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
123,
127
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4343
|
split_0_train_4343
|
[
{
"id": "split_0_train_4343_passage",
"type": "progene_text",
"text": [
"Transcription factors of the AP-1 / ATF family , including c-Fos , c-Jun , and ATF-2 , play an important role in the regulation of cell proliferation and differentiation , and changes in their levels and/or activities may contribute to oncogenesis ."
],
"offsets": [
[
0,
249
]
]
}
] |
[
{
"id": "split_0_train_6768_entity",
"type": "progene_text",
"text": [
"Transcription factors"
],
"offsets": [
[
0,
21
]
],
"normalized": []
},
{
"id": "split_0_train_6769_entity",
"type": "progene_text",
"text": [
"AP-1 / ATF family"
],
"offsets": [
[
29,
46
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],
"normalized": []
},
{
"id": "split_0_train_6770_entity",
"type": "progene_text",
"text": [
"c-Fos"
],
"offsets": [
[
59,
64
]
],
"normalized": []
},
{
"id": "split_0_train_6771_entity",
"type": "progene_text",
"text": [
"c-Jun"
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"offsets": [
[
67,
72
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],
"normalized": []
},
{
"id": "split_0_train_6772_entity",
"type": "progene_text",
"text": [
"ATF-2"
],
"offsets": [
[
79,
84
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4344
|
split_0_train_4344
|
[
{
"id": "split_0_train_4344_passage",
"type": "progene_text",
"text": [
"We analyzed the alterations of AP-1 / ATF transcription factors upon immortalization and transformation in a panel of cell lines derived from rat embryo fibroblast ( REF ) cells ."
],
"offsets": [
[
0,
179
]
]
}
] |
[
{
"id": "split_0_train_6773_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
31,
35
]
],
"normalized": []
},
{
"id": "split_0_train_6774_entity",
"type": "progene_text",
"text": [
"ATF"
],
"offsets": [
[
38,
41
]
],
"normalized": []
},
{
"id": "split_0_train_6775_entity",
"type": "progene_text",
"text": [
"transcription factors"
],
"offsets": [
[
42,
63
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4345
|
split_0_train_4345
|
[
{
"id": "split_0_train_4345_passage",
"type": "progene_text",
"text": [
"The tumorigenic E1A + cHa-ras cells are characterized by high and constitutive DNA binding activities of AP-1 , in contrast to nontransformed cells and the E1A cells ."
],
"offsets": [
[
0,
167
]
]
}
] |
[
{
"id": "split_0_train_6776_entity",
"type": "progene_text",
"text": [
"E1A"
],
"offsets": [
[
16,
19
]
],
"normalized": []
},
{
"id": "split_0_train_6777_entity",
"type": "progene_text",
"text": [
"cHa-ras"
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"offsets": [
[
22,
29
]
],
"normalized": []
},
{
"id": "split_0_train_6778_entity",
"type": "progene_text",
"text": [
"AP-1"
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"offsets": [
[
105,
109
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],
"normalized": []
},
{
"id": "split_0_train_6779_entity",
"type": "progene_text",
"text": [
"E1A"
],
"offsets": [
[
156,
159
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4346
|
split_0_train_4346
|
[
{
"id": "split_0_train_4346_passage",
"type": "progene_text",
"text": [
"The expression of c-fos and c-jun genes was affected differently by the oncogenic transformation ."
],
"offsets": [
[
0,
98
]
]
}
] |
[
{
"id": "split_0_train_6780_entity",
"type": "progene_text",
"text": [
"c-fos"
],
"offsets": [
[
18,
23
]
],
"normalized": []
},
{
"id": "split_0_train_6781_entity",
"type": "progene_text",
"text": [
"c-jun"
],
"offsets": [
[
28,
33
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4347
|
split_0_train_4347
|
[
{
"id": "split_0_train_4347_passage",
"type": "progene_text",
"text": [
"By using antibodies to c-Jun and c-Fos proteins in electrophoretic mobility shift assays ( EMSA ) , we showed that E1A + cHa-ras transformants did not contain c-Fos under any condition of cell cultivation and growth factor stimulation , whereas c-Jun was constitutively upregulated ."
],
"offsets": [
[
0,
283
]
]
}
] |
[
{
"id": "split_0_train_6782_entity",
"type": "progene_text",
"text": [
"c-Jun"
],
"offsets": [
[
23,
28
]
],
"normalized": []
},
{
"id": "split_0_train_6783_entity",
"type": "progene_text",
"text": [
"c-Fos"
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"offsets": [
[
33,
38
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],
"normalized": []
},
{
"id": "split_0_train_6784_entity",
"type": "progene_text",
"text": [
"E1A"
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"offsets": [
[
115,
118
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],
"normalized": []
},
{
"id": "split_0_train_6785_entity",
"type": "progene_text",
"text": [
"cHa-ras"
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"offsets": [
[
121,
128
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],
"normalized": []
},
{
"id": "split_0_train_6786_entity",
"type": "progene_text",
"text": [
"c-Fos"
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"offsets": [
[
159,
164
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],
"normalized": []
},
{
"id": "split_0_train_6787_entity",
"type": "progene_text",
"text": [
"growth factor"
],
"offsets": [
[
209,
222
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],
"normalized": []
},
{
"id": "split_0_train_6788_entity",
"type": "progene_text",
"text": [
"c-Jun"
],
"offsets": [
[
245,
250
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4348
|
split_0_train_4348
|
[
{
"id": "split_0_train_4348_passage",
"type": "progene_text",
"text": [
"In the absence of c-fos gene expression , c-Fos protein appears to be replaced by proteins of Fos family ( Fra-1 ) and ATF family ( ATF-2 and ATFa ) ."
],
"offsets": [
[
0,
150
]
]
}
] |
[
{
"id": "split_0_train_6789_entity",
"type": "progene_text",
"text": [
"c-fos"
],
"offsets": [
[
18,
23
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],
"normalized": []
},
{
"id": "split_0_train_6790_entity",
"type": "progene_text",
"text": [
"c-Fos"
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"offsets": [
[
42,
47
]
],
"normalized": []
},
{
"id": "split_0_train_6791_entity",
"type": "progene_text",
"text": [
"Fos family"
],
"offsets": [
[
94,
104
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],
"normalized": []
},
{
"id": "split_0_train_6792_entity",
"type": "progene_text",
"text": [
"Fra-1"
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"offsets": [
[
107,
112
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],
"normalized": []
},
{
"id": "split_0_train_6793_entity",
"type": "progene_text",
"text": [
"ATF family"
],
"offsets": [
[
119,
129
]
],
"normalized": []
},
{
"id": "split_0_train_6794_entity",
"type": "progene_text",
"text": [
"ATF-2"
],
"offsets": [
[
132,
137
]
],
"normalized": []
},
{
"id": "split_0_train_6795_entity",
"type": "progene_text",
"text": [
"ATFa"
],
"offsets": [
[
142,
146
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4349
|
split_0_train_4349
|
[
{
"id": "split_0_train_4349_passage",
"type": "progene_text",
"text": [
"To determine the possible mechanisms of c-fos downregulation in E1A + cHa-ras transformants we have obtained populations of geneticin - resistant clones containing integrated reporter construct - 711fos - CAT and its mutants in serum - responsive element ( SRE ) and cAMP - responsive element ( CRE ) ."
],
"offsets": [
[
0,
302
]
]
}
] |
[
{
"id": "split_0_train_6796_entity",
"type": "progene_text",
"text": [
"c-fos"
],
"offsets": [
[
40,
45
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"normalized": []
},
{
"id": "split_0_train_6797_entity",
"type": "progene_text",
"text": [
"E1A"
],
"offsets": [
[
64,
67
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],
"normalized": []
},
{
"id": "split_0_train_6798_entity",
"type": "progene_text",
"text": [
"cHa-ras"
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"offsets": [
[
70,
77
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],
"normalized": []
},
{
"id": "split_0_train_6799_entity",
"type": "progene_text",
"text": [
"CAT"
],
"offsets": [
[
205,
208
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4350
|
split_0_train_4350
|
[
{
"id": "split_0_train_4350_passage",
"type": "progene_text",
"text": [
"Data obtained show that the mutations within the SRE lead to a manifold activation of fos - CAT expression ."
],
"offsets": [
[
0,
108
]
]
}
] |
[
{
"id": "split_0_train_6800_entity",
"type": "progene_text",
"text": [
"fos"
],
"offsets": [
[
86,
89
]
],
"normalized": []
},
{
"id": "split_0_train_6801_entity",
"type": "progene_text",
"text": [
"CAT"
],
"offsets": [
[
92,
95
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4351
|
split_0_train_4351
|
[
{
"id": "split_0_train_4351_passage",
"type": "progene_text",
"text": [
"This allows to suggest that c-fos downregulation in E1A + cHa-ras transformants is provided by a negative control mediated through the SRE regulatory region ."
],
"offsets": [
[
0,
158
]
]
}
] |
[
{
"id": "split_0_train_6802_entity",
"type": "progene_text",
"text": [
"c-fos"
],
"offsets": [
[
28,
33
]
],
"normalized": []
},
{
"id": "split_0_train_6803_entity",
"type": "progene_text",
"text": [
"E1A"
],
"offsets": [
[
52,
55
]
],
"normalized": []
},
{
"id": "split_0_train_6804_entity",
"type": "progene_text",
"text": [
"cHa-ras"
],
"offsets": [
[
58,
65
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4352
|
split_0_train_4352
|
[
{
"id": "split_0_train_4352_passage",
"type": "progene_text",
"text": [
"The profound differences in regulation and composition of transcription factors of the AP-1 family probably play a pivotal role in the transformation of REF cells by E1A and cHa-ras oncogenes ."
],
"offsets": [
[
0,
193
]
]
}
] |
[
{
"id": "split_0_train_6805_entity",
"type": "progene_text",
"text": [
"AP-1 family"
],
"offsets": [
[
87,
98
]
],
"normalized": []
},
{
"id": "split_0_train_6806_entity",
"type": "progene_text",
"text": [
"E1A"
],
"offsets": [
[
166,
169
]
],
"normalized": []
},
{
"id": "split_0_train_6807_entity",
"type": "progene_text",
"text": [
"cHa-ras"
],
"offsets": [
[
174,
181
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4353
|
split_0_train_4353
|
[
{
"id": "split_0_train_4353_passage",
"type": "progene_text",
"text": [
"Retinoic acid selectively activates the ERK2 but not JNK / SAPK or p38 MAP kinases when inducing myeloid differentiation ."
],
"offsets": [
[
0,
122
]
]
}
] |
[
{
"id": "split_0_train_6808_entity",
"type": "progene_text",
"text": [
"ERK2"
],
"offsets": [
[
40,
44
]
],
"normalized": []
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[] |
[] |
[] |
split_0_train_4354
|
split_0_train_4354
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"Among the three major mitogen - activated protein kinase ( MAPK ) cascades - - the extracellular signal regulated kinase ( ERK ) pathway , the c-JUN N - terminal / stress - activated protein kinase ( JNK / SAPK ) pathway , and the reactivating kinase ( p38 ) pathway--retinoic acid selectively utilizes ERK but not JNK / SAPK or p38 when inducing myeloid differentiation of HL-60 human myeloblastic leukemia cells ."
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329,
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}
] |
[] |
[] |
[] |
split_0_train_4355
|
split_0_train_4355
|
[
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"type": "progene_text",
"text": [
"Retinoic acid is known to activate ERK2 ."
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0,
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}
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{
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"text": [
"ERK2"
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[
35,
39
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}
] |
[] |
[] |
[] |
split_0_train_4356
|
split_0_train_4356
|
[
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"type": "progene_text",
"text": [
"The present data show that the activation is selective for this MAPK pathway ."
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0,
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"type": "progene_text",
"text": [
"MAPK"
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[
64,
68
]
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}
] |
[] |
[] |
[] |
split_0_train_4357
|
split_0_train_4357
|
[
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"type": "progene_text",
"text": [
"JNK / SAPK or p38 are not activated by retinoic acid ."
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0,
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}
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{
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"text": [
"p38"
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14,
17
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}
] |
[] |
[] |
[] |
split_0_train_4358
|
split_0_train_4358
|
[
{
"id": "split_0_train_4358_passage",
"type": "progene_text",
"text": [
"Presumably because it activates relevant signaling pathways including MAPK , the polyoma middle T antigen , as well as certain transformation defective mutants thereof , is known to promote retinoic acid - induced differentiation , although the mechanism of action is not well understood ."
],
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[
0,
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]
}
] |
[
{
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{
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"type": "progene_text",
"text": [
"middle T antigen"
],
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[
89,
105
]
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"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4359
|
split_0_train_4359
|
[
{
"id": "split_0_train_4359_passage",
"type": "progene_text",
"text": [
"The present results show that consistent with the selective involvement of ERK2 , ectopic expression of either the polyoma middle T antigen or its dl23 mutant , which is defective for PLCgamma and PI-3 kinase activation , or the delta205 mutant , which in addition is also weakened for activation of src - like kinases , caused no enhanced JNK / SAPK or p38 kinase activity that promoted the effects of retinoic acid ."
],
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[
0,
418
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]
}
] |
[
{
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{
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346,
350
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{
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"type": "progene_text",
"text": [
"p38 kinase"
],
"offsets": [
[
354,
364
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4360
|
split_0_train_4360
|
[
{
"id": "split_0_train_4360_passage",
"type": "progene_text",
"text": [
"However , all three of these polyoma antigens are known to enhance ERK2 activation and promote differentiation induced by retinoic acid ."
],
"offsets": [
[
0,
137
]
]
}
] |
[
{
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"type": "progene_text",
"text": [
"ERK2"
],
"offsets": [
[
67,
71
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4361
|
split_0_train_4361
|
[
{
"id": "split_0_train_4361_passage",
"type": "progene_text",
"text": [
"Polyoma - activated MAPK signaling relevant to retinoic acid - induced differentiation is thus restricted to ERK2 and does not involve JNK / SAPK or p38 ."
],
"offsets": [
[
0,
154
]
]
}
] |
[
{
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20,
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{
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{
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135,
138
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{
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141,
145
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{
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"type": "progene_text",
"text": [
"p38"
],
"offsets": [
[
149,
152
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4362
|
split_0_train_4362
|
[
{
"id": "split_0_train_4362_passage",
"type": "progene_text",
"text": [
"Taken together , the data indicate that among the three parallel MAPK pathways , retinoic acid - induced HL-60 myeloid differentiation selectively depends on activating ERK but not the other two MAPK pathways , JNK / SAPK or p38 , with no apparent cross talk between pathways ."
],
"offsets": [
[
0,
277
]
]
}
] |
[
{
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65,
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{
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195,
199
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},
{
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211,
214
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{
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"SAPK"
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217,
221
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},
{
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"type": "progene_text",
"text": [
"p38"
],
"offsets": [
[
225,
228
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4363
|
split_0_train_4363
|
[
{
"id": "split_0_train_4363_passage",
"type": "progene_text",
"text": [
"Furthermore , the striking ability of polyoma middle T antigens to promote retinoic acid - induced differentiation appears to utilize ERK , but not JNK / SPK or p38 signaling ."
],
"offsets": [
[
0,
176
]
]
}
] |
[
{
"id": "split_0_train_6853_entity",
"type": "progene_text",
"text": [
"middle T antigens"
],
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[
46,
63
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},
{
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"type": "progene_text",
"text": [
"ERK"
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134,
137
]
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},
{
"id": "split_0_train_6855_entity",
"type": "progene_text",
"text": [
"JNK"
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148,
151
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},
{
"id": "split_0_train_6856_entity",
"type": "progene_text",
"text": [
"SPK"
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[
154,
157
]
],
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},
{
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"type": "progene_text",
"text": [
"p38"
],
"offsets": [
[
161,
164
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4364
|
split_0_train_4364
|
[
{
"id": "split_0_train_4364_passage",
"type": "progene_text",
"text": [
"Structure and properties of cast binary Ti - Mo alloys ."
],
"offsets": [
[
0,
56
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4365
|
split_0_train_4365
|
[
{
"id": "split_0_train_4365_passage",
"type": "progene_text",
"text": [
"Structure and properties of a series of binary Ti - Mo alloys with molybdenum contents ranging from 6 to 20 wt % have been investigated ."
],
"offsets": [
[
0,
137
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4366
|
split_0_train_4366
|
[
{
"id": "split_0_train_4366_passage",
"type": "progene_text",
"text": [
"Experimental results indicated that crystal structure and morphology of the cast alloys were sensitive to their molybdenum contents ."
],
"offsets": [
[
0,
133
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4367
|
split_0_train_4367
|
[
{
"id": "split_0_train_4367_passage",
"type": "progene_text",
"text": [
"The hexagonal alpha' phase c.p ."
],
"offsets": [
[
0,
32
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4368
|
split_0_train_4368
|
[
{
"id": "split_0_train_4368_passage",
"type": "progene_text",
"text": [
"Ti exhibited a feather - like morphology ."
],
"offsets": [
[
0,
42
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4369
|
split_0_train_4369
|
[
{
"id": "split_0_train_4369_passage",
"type": "progene_text",
"text": [
"When Mo content was 6 wt % , a fine , acicular martensitic structure of orthorhombic alpha \" phase was observed ."
],
"offsets": [
[
0,
113
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4370
|
split_0_train_4370
|
[
{
"id": "split_0_train_4370_passage",
"type": "progene_text",
"text": [
"When Mo content was 7.5 wt % , the entire alloy was dominated by the martensitic alpha \" structure ."
],
"offsets": [
[
0,
100
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4371
|
split_0_train_4371
|
[
{
"id": "split_0_train_4371_passage",
"type": "progene_text",
"text": [
"When Mo content was increased to 10 wt % or higher , the retained beta phase became the only dominant phase ."
],
"offsets": [
[
0,
109
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4372
|
split_0_train_4372
|
[
{
"id": "split_0_train_4372_passage",
"type": "progene_text",
"text": [
"Among all Ti - Mo alloys , the alpha \" phase Ti-7.5Mo alloy had the lowest hardness ."
],
"offsets": [
[
0,
85
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4373
|
split_0_train_4373
|
[
{
"id": "split_0_train_4373_passage",
"type": "progene_text",
"text": [
"The bending strength of Ti-7.5Mo was similar to that of Ti-15Mo and Ti-13Nb-13Zr , and higher than c.p ."
],
"offsets": [
[
0,
104
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4374
|
split_0_train_4374
|
[
{
"id": "split_0_train_4374_passage",
"type": "progene_text",
"text": [
"Ti by nearly 60 % ."
],
"offsets": [
[
0,
19
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4375
|
split_0_train_4375
|
[
{
"id": "split_0_train_4375_passage",
"type": "progene_text",
"text": [
"The bending modulus of the alpha \" - dominated Ti-7.5Mo alloy was lower than that of Ti-15Mo by 22 % , of Ti-6A1-4V by 47 % , of Ti-13Nb-13Zr by 17 % , and of c.p ."
],
"offsets": [
[
0,
164
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4376
|
split_0_train_4376
|
[
{
"id": "split_0_train_4376_passage",
"type": "progene_text",
"text": [
"Ti by 40 % ."
],
"offsets": [
[
0,
12
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4377
|
split_0_train_4377
|
[
{
"id": "split_0_train_4377_passage",
"type": "progene_text",
"text": [
"Dry powder versus intravenous and nebulized gentamicin in cystic fibrosis and bronchiectasis ."
],
"offsets": [
[
0,
94
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4378
|
split_0_train_4378
|
[
{
"id": "split_0_train_4378_passage",
"type": "progene_text",
"text": [
"A pilot study ."
],
"offsets": [
[
0,
15
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4379
|
split_0_train_4379
|
[
{
"id": "split_0_train_4379_passage",
"type": "progene_text",
"text": [
"Aminoglycosides are a mainstay of therapy for patients with cystic fibrosis ( CF ) or non - CF bronchiectasis who are infected with Pseudomonas aeruginosa ( Psa ) ."
],
"offsets": [
[
0,
164
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4380
|
split_0_train_4380
|
[
{
"id": "split_0_train_4380_passage",
"type": "progene_text",
"text": [
"Traditionally , aerosolized antibiotics are delivered by liquid nebulization ."
],
"offsets": [
[
0,
78
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4381
|
split_0_train_4381
|
[
{
"id": "split_0_train_4381_passage",
"type": "progene_text",
"text": [
"The objective of this study was to determine whether a gentamicin dry powder inhaler ( DPI ) is as microbiologically active and potentially safe as gentamicin inhaled via a small - volume nebulizer ( SVN ) or given intravenously ."
],
"offsets": [
[
0,
230
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4382
|
split_0_train_4382
|
[
{
"id": "split_0_train_4382_passage",
"type": "progene_text",
"text": [
"The study was done according to a randomized , single - dose , and triple crossover protocol ."
],
"offsets": [
[
0,
94
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4383
|
split_0_train_4383
|
[
{
"id": "split_0_train_4383_passage",
"type": "progene_text",
"text": [
"Ten patients with CF or non - CF bronchiectasis and chronically infected with Psa were recruited ."
],
"offsets": [
[
0,
98
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4384
|
split_0_train_4384
|
[
{
"id": "split_0_train_4384_passage",
"type": "progene_text",
"text": [
"Patients received a single dose of either gentamicin 160 mg via DPI or SVN , or gentamicin at 5 mg / kg by intravenous infusion ."
],
"offsets": [
[
0,
129
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4385
|
split_0_train_4385
|
[
{
"id": "split_0_train_4385_passage",
"type": "progene_text",
"text": [
"In seven of the 10 patients , the minimum inhibitory concentration ( MIC ) was achieved in sputum after DPI and SVN , with mean ( 95 % confidence interval ) gentamicin concentrations at 2 h after administration of 13.1 microgram / g sputum ( range : 2.2 to 23.9 microgram / g ) and 97.2 microgram / g sputum ( range : 0.3 to 194.2 microgram / g ) , respectively , whereas gentamicin levels in the sputum after intravenous administration failed to reach the MIC ."
],
"offsets": [
[
0,
462
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4386
|
split_0_train_4386
|
[
{
"id": "split_0_train_4386_passage",
"type": "progene_text",
"text": [
"Gentamicin given by DPI and SVN significantly decreased the sputum Psa density ( p < 0.05 ) , by almost one order of magnitude ."
],
"offsets": [
[
0,
128
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4387
|
split_0_train_4387
|
[
{
"id": "split_0_train_4387_passage",
"type": "progene_text",
"text": [
"No significant decline in bacterial counts was observed after intravenous gentamicin ."
],
"offsets": [
[
0,
86
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4388
|
split_0_train_4388
|
[
{
"id": "split_0_train_4388_passage",
"type": "progene_text",
"text": [
"When gentamicin was inhaled , blood concentrations were minimal , and were below concentrations known to cause systemic toxicity ."
],
"offsets": [
[
0,
130
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4389
|
split_0_train_4389
|
[
{
"id": "split_0_train_4389_passage",
"type": "progene_text",
"text": [
"For treatment of Psa infections susceptible to gentamicin , gentamicin administration by DPI appeared to be as efficient as by SVN , despite the delivery of a 7 - fold lower dose to the airways ."
],
"offsets": [
[
0,
195
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4390
|
split_0_train_4390
|
[
{
"id": "split_0_train_4390_passage",
"type": "progene_text",
"text": [
"Induction of transformation and p53 - dependent apoptosis by adenovirus type 5 E4orf6 / 7 cDNA ."
],
"offsets": [
[
0,
96
]
]
}
] |
[
{
"id": "split_0_train_6858_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
32,
35
]
],
"normalized": []
},
{
"id": "split_0_train_6859_entity",
"type": "progene_text",
"text": [
"E4orf6 / 7"
],
"offsets": [
[
79,
89
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4391
|
split_0_train_4391
|
[
{
"id": "split_0_train_4391_passage",
"type": "progene_text",
"text": [
"Adenovirus ( Ad ) E4orf6 / 7 , one of the early gene products of human Ads , forms a stable complex with the cellular transcription factor E2F to activate transcription from the Ad E2 promoter ."
],
"offsets": [
[
0,
194
]
]
}
] |
[
{
"id": "split_0_train_6860_entity",
"type": "progene_text",
"text": [
"E4orf6 / 7"
],
"offsets": [
[
18,
28
]
],
"normalized": []
},
{
"id": "split_0_train_6861_entity",
"type": "progene_text",
"text": [
"transcription factor"
],
"offsets": [
[
118,
138
]
],
"normalized": []
},
{
"id": "split_0_train_6862_entity",
"type": "progene_text",
"text": [
"E2F"
],
"offsets": [
[
139,
142
]
],
"normalized": []
},
{
"id": "split_0_train_6863_entity",
"type": "progene_text",
"text": [
"E2"
],
"offsets": [
[
181,
183
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4392
|
split_0_train_4392
|
[
{
"id": "split_0_train_4392_passage",
"type": "progene_text",
"text": [
"E2F cDNAs have growth - promoting and apoptosis - inducing activities when overexpressed in cells ."
],
"offsets": [
[
0,
99
]
]
}
] |
[
{
"id": "split_0_train_6864_entity",
"type": "progene_text",
"text": [
"E2F"
],
"offsets": [
[
0,
3
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4393
|
split_0_train_4393
|
[
{
"id": "split_0_train_4393_passage",
"type": "progene_text",
"text": [
"We cloned Ad5 E4orf6 / 7 cDNA in both simian virus 40 - and human cytomegalovirus - based expression vectors to examine its transforming and apoptotic activities ."
],
"offsets": [
[
0,
163
]
]
}
] |
[
{
"id": "split_0_train_6865_entity",
"type": "progene_text",
"text": [
"E4orf6 / 7"
],
"offsets": [
[
14,
24
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4394
|
split_0_train_4394
|
[
{
"id": "split_0_train_4394_passage",
"type": "progene_text",
"text": [
"The cloned E4orf6 / 7 collaborated with a retinoblastoma protein ( RB ) - nonbinding and therefore E2F - nonreleasing mutant of Ad5 E1A ( dl922 / 947 ) to morphologically transform primary rat cells , suggesting that E2F is an important cellular protein functioning downstream of E1A for transformation ."
],
"offsets": [
[
0,
304
]
]
}
] |
[
{
"id": "split_0_train_6866_entity",
"type": "progene_text",
"text": [
"E4orf6 / 7"
],
"offsets": [
[
11,
21
]
],
"normalized": []
},
{
"id": "split_0_train_6867_entity",
"type": "progene_text",
"text": [
"retinoblastoma protein"
],
"offsets": [
[
42,
64
]
],
"normalized": []
},
{
"id": "split_0_train_6868_entity",
"type": "progene_text",
"text": [
"RB"
],
"offsets": [
[
67,
69
]
],
"normalized": []
},
{
"id": "split_0_train_6869_entity",
"type": "progene_text",
"text": [
"E2F"
],
"offsets": [
[
99,
102
]
],
"normalized": []
},
{
"id": "split_0_train_6870_entity",
"type": "progene_text",
"text": [
"E1A"
],
"offsets": [
[
132,
135
]
],
"normalized": []
},
{
"id": "split_0_train_6871_entity",
"type": "progene_text",
"text": [
"E2F"
],
"offsets": [
[
217,
220
]
],
"normalized": []
},
{
"id": "split_0_train_6872_entity",
"type": "progene_text",
"text": [
"E1A"
],
"offsets": [
[
280,
283
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4395
|
split_0_train_4395
|
[
{
"id": "split_0_train_4395_passage",
"type": "progene_text",
"text": [
"In a G418 colony formation assay , E4orf6 / 7 was shown to suppress growth of untransformed rat cells ."
],
"offsets": [
[
0,
103
]
]
}
] |
[
{
"id": "split_0_train_6873_entity",
"type": "progene_text",
"text": [
"E4orf6 / 7"
],
"offsets": [
[
35,
45
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4396
|
split_0_train_4396
|
[
{
"id": "split_0_train_4396_passage",
"type": "progene_text",
"text": [
"Moreover , a recombinant Ad expressing Ad5 E4orf6 / 7 induced apoptosis in rat cells when coinfected with wild - type p53 - expressing Ad ."
],
"offsets": [
[
0,
139
]
]
}
] |
[
{
"id": "split_0_train_6874_entity",
"type": "progene_text",
"text": [
"E4orf6 / 7"
],
"offsets": [
[
43,
53
]
],
"normalized": []
},
{
"id": "split_0_train_6875_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
118,
121
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4397
|
split_0_train_4397
|
[
{
"id": "split_0_train_4397_passage",
"type": "progene_text",
"text": [
"Mutational analysis of E4orf6 / 7 revealed that both of the domains required for growth inhibition and transformation by E4orf6 / 7 lay in the C - terminal region , which is essential for transactivation from the upstream sequence of an E2a promoter containing E2F - binding sites ."
],
"offsets": [
[
0,
282
]
]
}
] |
[
{
"id": "split_0_train_6876_entity",
"type": "progene_text",
"text": [
"E4orf6 / 7"
],
"offsets": [
[
23,
33
]
],
"normalized": []
},
{
"id": "split_0_train_6877_entity",
"type": "progene_text",
"text": [
"E4orf6 / 7"
],
"offsets": [
[
121,
131
]
],
"normalized": []
},
{
"id": "split_0_train_6878_entity",
"type": "progene_text",
"text": [
"E2a"
],
"offsets": [
[
237,
240
]
],
"normalized": []
},
{
"id": "split_0_train_6879_entity",
"type": "progene_text",
"text": [
"E2F"
],
"offsets": [
[
261,
264
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4398
|
split_0_train_4398
|
[
{
"id": "split_0_train_4398_passage",
"type": "progene_text",
"text": [
"However , the smallest mutant of E4orf6 / 7 , encoding the C-terminal 59 amino acids , failed to complement the RB - nonbinding dl922 / 947 mutant despite showing growth inhibition and E2F transactivation activities ."
],
"offsets": [
[
0,
217
]
]
}
] |
[
{
"id": "split_0_train_6880_entity",
"type": "progene_text",
"text": [
"E4orf6 / 7"
],
"offsets": [
[
33,
43
]
],
"normalized": []
},
{
"id": "split_0_train_6881_entity",
"type": "progene_text",
"text": [
"RB"
],
"offsets": [
[
112,
114
]
],
"normalized": []
},
{
"id": "split_0_train_6882_entity",
"type": "progene_text",
"text": [
"E2F"
],
"offsets": [
[
185,
188
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4399
|
split_0_train_4399
|
[
{
"id": "split_0_train_4399_passage",
"type": "progene_text",
"text": [
"Thus , it is suggested that a subregion of E4orf6 / 7 which is required for growth inhibition and transformation in collaboration with dl922 / 947 overlaps the transactivation domain of E4orf6 / 7 ."
],
"offsets": [
[
0,
198
]
]
}
] |
[
{
"id": "split_0_train_6883_entity",
"type": "progene_text",
"text": [
"E4orf6 / 7"
],
"offsets": [
[
43,
53
]
],
"normalized": []
},
{
"id": "split_0_train_6884_entity",
"type": "progene_text",
"text": [
"E4orf6 / 7"
],
"offsets": [
[
186,
196
]
],
"normalized": []
}
] |
[] |
[] |
[] |
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