id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_4200
|
split_0_train_4200
|
[
{
"id": "split_0_train_4200_passage",
"type": "progene_text",
"text": [
"Differential expression was confirmed by Northern blot analysis employing multiple normal and tumor cell lines ."
],
"offsets": [
[
0,
112
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4201
|
split_0_train_4201
|
[
{
"id": "split_0_train_4201_passage",
"type": "progene_text",
"text": [
"The promoter region - 619 to + 15 of the SPR1 gene was sequenced and analyzed by CAT assays , deletion analysis , and mutagenesis ."
],
"offsets": [
[
0,
131
]
]
}
] |
[
{
"id": "split_0_train_6568_entity",
"type": "progene_text",
"text": [
"SPR1"
],
"offsets": [
[
41,
45
]
],
"normalized": []
},
{
"id": "split_0_train_6569_entity",
"type": "progene_text",
"text": [
"CAT"
],
"offsets": [
[
81,
84
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4202
|
split_0_train_4202
|
[
{
"id": "split_0_train_4202_passage",
"type": "progene_text",
"text": [
"Up - regulation of SPR1 expression by PMA and UV irradiation was monitored by Northern analysis and analyzed by CAT assays ."
],
"offsets": [
[
0,
124
]
]
}
] |
[
{
"id": "split_0_train_6570_entity",
"type": "progene_text",
"text": [
"SPR1"
],
"offsets": [
[
19,
23
]
],
"normalized": []
},
{
"id": "split_0_train_6571_entity",
"type": "progene_text",
"text": [
"CAT"
],
"offsets": [
[
112,
115
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4203
|
split_0_train_4203
|
[
{
"id": "split_0_train_4203_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4204
|
split_0_train_4204
|
[
{
"id": "split_0_train_4204_passage",
"type": "progene_text",
"text": [
"The mechanism of down - regulation of SPR1 expression in breast tumor cells was investigated ."
],
"offsets": [
[
0,
94
]
]
}
] |
[
{
"id": "split_0_train_6572_entity",
"type": "progene_text",
"text": [
"SPR1"
],
"offsets": [
[
38,
42
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4205
|
split_0_train_4205
|
[
{
"id": "split_0_train_4205_passage",
"type": "progene_text",
"text": [
"It was found that the - 619 to + 15 upstream promoter region is sufficient for SPR1 expression in normal breast cells , but it is transcriptionally silent in most breast tumor cell lines ."
],
"offsets": [
[
0,
188
]
]
}
] |
[
{
"id": "split_0_train_6573_entity",
"type": "progene_text",
"text": [
"SPR1"
],
"offsets": [
[
79,
83
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4206
|
split_0_train_4206
|
[
{
"id": "split_0_train_4206_passage",
"type": "progene_text",
"text": [
"By deletion analysis and mutagenesis , two upstream cis - acting promoter elements were identified ."
],
"offsets": [
[
0,
100
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4207
|
split_0_train_4207
|
[
{
"id": "split_0_train_4207_passage",
"type": "progene_text",
"text": [
"Our data indicate that the AP-1 element located between - 139 and - 133 acts as a major enhancer of SPR1 transcription only in normal mammary epithelial cells but not in corresponding tumor cells , whereas the sequences flanking the AP-1 site do not affect its promoter enhancing activity ."
],
"offsets": [
[
0,
290
]
]
}
] |
[
{
"id": "split_0_train_6574_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
27,
31
]
],
"normalized": []
},
{
"id": "split_0_train_6575_entity",
"type": "progene_text",
"text": [
"SPR1"
],
"offsets": [
[
100,
104
]
],
"normalized": []
},
{
"id": "split_0_train_6576_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
233,
237
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4208
|
split_0_train_4208
|
[
{
"id": "split_0_train_4208_passage",
"type": "progene_text",
"text": [
"In addition , a transcriptional repressor was identified that binds unknown factor(s) and is active in both normal and tumor breast cells ."
],
"offsets": [
[
0,
139
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4209
|
split_0_train_4209
|
[
{
"id": "split_0_train_4209_passage",
"type": "progene_text",
"text": [
"Inhibitor function was mapped to a 35 - bp element located from - 178 to - 139 upstream of the human SPR1 mRNA start site ."
],
"offsets": [
[
0,
123
]
]
}
] |
[
{
"id": "split_0_train_6577_entity",
"type": "progene_text",
"text": [
"SPR1"
],
"offsets": [
[
101,
105
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4210
|
split_0_train_4210
|
[
{
"id": "split_0_train_4210_passage",
"type": "progene_text",
"text": [
"The expression of SPR1 could be induced in the 21MT-2 metastatic breast tumor cell line by PMA treatment or by short UV irradiation via a transcriptional mechanism ."
],
"offsets": [
[
0,
165
]
]
}
] |
[
{
"id": "split_0_train_6578_entity",
"type": "progene_text",
"text": [
"SPR1"
],
"offsets": [
[
18,
22
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4211
|
split_0_train_4211
|
[
{
"id": "split_0_train_4211_passage",
"type": "progene_text",
"text": [
"AP-1 is the cis element mediating the transcriptional activation of SPR1 by PMA , which induces the expression of AP-1 factors in 21MT-2 cells ."
],
"offsets": [
[
0,
144
]
]
}
] |
[
{
"id": "split_0_train_6579_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_6580_entity",
"type": "progene_text",
"text": [
"SPR1"
],
"offsets": [
[
68,
72
]
],
"normalized": []
},
{
"id": "split_0_train_6581_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
114,
118
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4212
|
split_0_train_4212
|
[
{
"id": "split_0_train_4212_passage",
"type": "progene_text",
"text": [
"Mutation of the AP-1 site abolishes the induction of SPR1 expression by PMA ."
],
"offsets": [
[
0,
77
]
]
}
] |
[
{
"id": "split_0_train_6582_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
16,
20
]
],
"normalized": []
},
{
"id": "split_0_train_6583_entity",
"type": "progene_text",
"text": [
"SPR1"
],
"offsets": [
[
53,
57
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4213
|
split_0_train_4213
|
[
{
"id": "split_0_train_4213_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4214
|
split_0_train_4214
|
[
{
"id": "split_0_train_4214_passage",
"type": "progene_text",
"text": [
"Our results demonstrate that loss of SPR1 expression in breast tumor cells results from impaired transactivation through the AP-1 site in the SPR1 promoter , as well as from the presence of a negative regulatory element active in both normal and tumor cells ."
],
"offsets": [
[
0,
259
]
]
}
] |
[
{
"id": "split_0_train_6584_entity",
"type": "progene_text",
"text": [
"SPR1"
],
"offsets": [
[
37,
41
]
],
"normalized": []
},
{
"id": "split_0_train_6585_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
125,
129
]
],
"normalized": []
},
{
"id": "split_0_train_6586_entity",
"type": "progene_text",
"text": [
"SPR1"
],
"offsets": [
[
142,
146
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4215
|
split_0_train_4215
|
[
{
"id": "split_0_train_4215_passage",
"type": "progene_text",
"text": [
"Furthermore , our results provide a basis for therapeutic manipulation of down - regulated genes , such as SPR1 , in human cancers ."
],
"offsets": [
[
0,
132
]
]
}
] |
[
{
"id": "split_0_train_6587_entity",
"type": "progene_text",
"text": [
"SPR1"
],
"offsets": [
[
107,
111
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4216
|
split_0_train_4216
|
[
{
"id": "split_0_train_4216_passage",
"type": "progene_text",
"text": [
"Cyclosporin pharmacokinetics in the elderly ."
],
"offsets": [
[
0,
45
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4217
|
split_0_train_4217
|
[
{
"id": "split_0_train_4217_passage",
"type": "progene_text",
"text": [
"Cyclosporin is an immunosuppressant used in organ transplantation and selected autoimmune diseases such as rheumatoid arthritis ."
],
"offsets": [
[
0,
129
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4218
|
split_0_train_4218
|
[
{
"id": "split_0_train_4218_passage",
"type": "progene_text",
"text": [
"In both these indications , the elderly represent an important and growing segment of the patient population ."
],
"offsets": [
[
0,
110
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4219
|
split_0_train_4219
|
[
{
"id": "split_0_train_4219_passage",
"type": "progene_text",
"text": [
"Cyclosporin is primarily eliminated via biotransformation by cytochrome P450 ( CYP ) 3A in the gut wall and liver ."
],
"offsets": [
[
0,
115
]
]
}
] |
[
{
"id": "split_0_train_6588_entity",
"type": "progene_text",
"text": [
"cytochrome P450 ( CYP ) 3A"
],
"offsets": [
[
61,
87
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4220
|
split_0_train_4220
|
[
{
"id": "split_0_train_4220_passage",
"type": "progene_text",
"text": [
"Additionally , P-glycoprotein ( mdr-1 ) located in the gastrointestinal epithelium can affect affect blood drug concentrations after oral administration of cyclosporin , presumably by counter - transporting the drug from the systemic circulation back into the gastrointestinal lumen ."
],
"offsets": [
[
0,
284
]
]
}
] |
[
{
"id": "split_0_train_6589_entity",
"type": "progene_text",
"text": [
"P-glycoprotein"
],
"offsets": [
[
15,
29
]
],
"normalized": []
},
{
"id": "split_0_train_6590_entity",
"type": "progene_text",
"text": [
"mdr-1"
],
"offsets": [
[
32,
37
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4221
|
split_0_train_4221
|
[
{
"id": "split_0_train_4221_passage",
"type": "progene_text",
"text": [
"Theoretically , age - related alterations in either of these pathways could affect cyclosporin disposition in the elderly ."
],
"offsets": [
[
0,
123
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4222
|
split_0_train_4222
|
[
{
"id": "split_0_train_4222_passage",
"type": "progene_text",
"text": [
"These general pharmacological considerations together with the narrow therapeutic index of cyclosporin between minimally immunosuppressive concentrations and those associated with adverse events , underscore the need for dedicated pharmacokinetic studies in the elderly ."
],
"offsets": [
[
0,
271
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4223
|
split_0_train_4223
|
[
{
"id": "split_0_train_4223_passage",
"type": "progene_text",
"text": [
"Single dose studies have demonstrated that cyclosporin pharmacokinetics are not different in healthy elderly individuals compared with healthy young adults , nor is the between - subject variability in pharmacokinetic parameters more heterogenous in healthy elderly individuals ."
],
"offsets": [
[
0,
279
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4224
|
split_0_train_4224
|
[
{
"id": "split_0_train_4224_passage",
"type": "progene_text",
"text": [
"Similarly , there were no apparent differences in cyclosporin disposition in elderly patients with rheumatoid arthritis compared with healthy young and elderly individuals ."
],
"offsets": [
[
0,
173
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4225
|
split_0_train_4225
|
[
{
"id": "split_0_train_4225_passage",
"type": "progene_text",
"text": [
"Whether pharmacokinetic variability may be increased in elderly patients has not been rigorously addressed and requires investigation in a larger patient population for a definitive conclusion ."
],
"offsets": [
[
0,
194
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4226
|
split_0_train_4226
|
[
{
"id": "split_0_train_4226_passage",
"type": "progene_text",
"text": [
"A population pharmacokinetic study of cyclosporin in organ transplant patients , including elderly allograft recipients up to 75 years of age , did not identify age as a covariable influencing cyclosporin pharmacokinetics ."
],
"offsets": [
[
0,
223
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4227
|
split_0_train_4227
|
[
{
"id": "split_0_train_4227_passage",
"type": "progene_text",
"text": [
"Hence , the available pharmacokinetic data in the elderly do not reveal any major differences from the disposition characterised in younger individuals ."
],
"offsets": [
[
0,
153
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4228
|
split_0_train_4228
|
[
{
"id": "split_0_train_4228_passage",
"type": "progene_text",
"text": [
"It is generally recognised that the elderly are more prone to drug - related adverse experiences and are at greater risk for drug - drug interactions secondary to polypharmacy ."
],
"offsets": [
[
0,
177
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4229
|
split_0_train_4229
|
[
{
"id": "split_0_train_4229_passage",
"type": "progene_text",
"text": [
"The former factor may underlie , in part , the increased incidence of renal adverse events reported in patients with rheumatoid arthritis over 65 years of age receiving cyclosporin ."
],
"offsets": [
[
0,
182
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4230
|
split_0_train_4230
|
[
{
"id": "split_0_train_4230_passage",
"type": "progene_text",
"text": [
"Clinical experience with cyclosporin in elderly organ transplant recipients has not revealed a tolerability profile remarkably different from those in younger patients ."
],
"offsets": [
[
0,
169
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4231
|
split_0_train_4231
|
[
{
"id": "split_0_train_4231_passage",
"type": "progene_text",
"text": [
"Polypharmacy may have specific relevance for elderly patients treated with cyclosporin since this agent is a substrate of both CYP3A and P-glycoprotein , both of which are important in the elimination of many commonly used drugs ."
],
"offsets": [
[
0,
230
]
]
}
] |
[
{
"id": "split_0_train_6591_entity",
"type": "progene_text",
"text": [
"CYP3A"
],
"offsets": [
[
127,
132
]
],
"normalized": []
},
{
"id": "split_0_train_6592_entity",
"type": "progene_text",
"text": [
"P-glycoprotein"
],
"offsets": [
[
137,
151
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4232
|
split_0_train_4232
|
[
{
"id": "split_0_train_4232_passage",
"type": "progene_text",
"text": [
"This implies that the clinician prescribing cyclosporin for an elderly patient must exercise a heightened awareness for potential drug - drug interactions which could affect the pharmacokinetics of cyclosporin ."
],
"offsets": [
[
0,
211
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4233
|
split_0_train_4233
|
[
{
"id": "split_0_train_4233_passage",
"type": "progene_text",
"text": [
"Based on the available cyclosporin pharmacokinetic data in adults , no age - related administration adaptations appear necessary for its use in the elderly ."
],
"offsets": [
[
0,
157
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4234
|
split_0_train_4234
|
[
{
"id": "split_0_train_4234_passage",
"type": "progene_text",
"text": [
"The effect of breakfast cereal on diet and serum cholesterol : a randomized trial in North Karelia , Finland ."
],
"offsets": [
[
0,
110
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4235
|
split_0_train_4235
|
[
{
"id": "split_0_train_4235_passage",
"type": "progene_text",
"text": [
"OBJECTIVE :"
],
"offsets": [
[
0,
11
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4236
|
split_0_train_4236
|
[
{
"id": "split_0_train_4236_passage",
"type": "progene_text",
"text": [
"To test the hypothesis that a high carbohydrate breakfast with breakfast cereal leads to a meaningful reduction in dietary energy intake from fat , especially from saturated fat , and thus lower serum cholesterol levels ."
],
"offsets": [
[
0,
221
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4237
|
split_0_train_4237
|
[
{
"id": "split_0_train_4237_passage",
"type": "progene_text",
"text": [
"DESIGN :"
],
"offsets": [
[
0,
8
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4238
|
split_0_train_4238
|
[
{
"id": "split_0_train_4238_passage",
"type": "progene_text",
"text": [
"An open randomized controlled cross - over trial ."
],
"offsets": [
[
0,
50
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4239
|
split_0_train_4239
|
[
{
"id": "split_0_train_4239_passage",
"type": "progene_text",
"text": [
"The subjects were randomized into intervention breakfast cereal or usual breakfast ( control ) groups ."
],
"offsets": [
[
0,
103
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4240
|
split_0_train_4240
|
[
{
"id": "split_0_train_4240_passage",
"type": "progene_text",
"text": [
"SETTING :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4241
|
split_0_train_4241
|
[
{
"id": "split_0_train_4241_passage",
"type": "progene_text",
"text": [
"Free - living subjects aged 29 - 71 y in Eastern Finland SUBJECTS : 224 enrolled , 209 completed the study ."
],
"offsets": [
[
0,
108
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4242
|
split_0_train_4242
|
[
{
"id": "split_0_train_4242_passage",
"type": "progene_text",
"text": [
"The subjects were recruited from a survey of a random population sample and from other sources , and their serum cholesterol was not lower than 5.0 mmol / l ."
],
"offsets": [
[
0,
158
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4243
|
split_0_train_4243
|
[
{
"id": "split_0_train_4243_passage",
"type": "progene_text",
"text": [
"Recruited persons did not have any chronic disease or very low saturated fat intake ."
],
"offsets": [
[
0,
85
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4244
|
split_0_train_4244
|
[
{
"id": "split_0_train_4244_passage",
"type": "progene_text",
"text": [
"INTERVENTION :"
],
"offsets": [
[
0,
14
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4245
|
split_0_train_4245
|
[
{
"id": "split_0_train_4245_passage",
"type": "progene_text",
"text": [
"The cereal group consumed 80 g ( men ) or 60 g ( women ) cereal at breakfast and the control group continued their usual dietary habits for six weeks ."
],
"offsets": [
[
0,
151
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4246
|
split_0_train_4246
|
[
{
"id": "split_0_train_4246_passage",
"type": "progene_text",
"text": [
"After a wash out of six weeks , a cross - over with another six week trial period took place ."
],
"offsets": [
[
0,
94
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4247
|
split_0_train_4247
|
[
{
"id": "split_0_train_4247_passage",
"type": "progene_text",
"text": [
"Measurements ( including serum samples and a 3 d food record ) took place before and after the two trial periods ."
],
"offsets": [
[
0,
114
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4248
|
split_0_train_4248
|
[
{
"id": "split_0_train_4248_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4249
|
split_0_train_4249
|
[
{
"id": "split_0_train_4249_passage",
"type": "progene_text",
"text": [
"The intervention period led to 2.5 en % ( energy percent units ) reduction in saturated fatty acids intake ."
],
"offsets": [
[
0,
108
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4250
|
split_0_train_4250
|
[
{
"id": "split_0_train_4250_passage",
"type": "progene_text",
"text": [
"The reduction in total fat intake was 5.5 en % ."
],
"offsets": [
[
0,
48
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4251
|
split_0_train_4251
|
[
{
"id": "split_0_train_4251_passage",
"type": "progene_text",
"text": [
"This was compensated for by increased intake of carbohydrates ."
],
"offsets": [
[
0,
63
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4252
|
split_0_train_4252
|
[
{
"id": "split_0_train_4252_passage",
"type": "progene_text",
"text": [
"The reduction in saturated fatty acids intake led to modest ( but in group 1 significant ) 0.15 mmol / l ( 2.5 % ) reduction in total serum cholesterol level ."
],
"offsets": [
[
0,
159
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4253
|
split_0_train_4253
|
[
{
"id": "split_0_train_4253_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4254
|
split_0_train_4254
|
[
{
"id": "split_0_train_4254_passage",
"type": "progene_text",
"text": [
"The trial showed that regular cereal breakfast can lead to reduced intake of total and saturated fatty acids of the daily diet and consequently to reduction in serum cholesterol level ."
],
"offsets": [
[
0,
185
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4255
|
split_0_train_4255
|
[
{
"id": "split_0_train_4255_passage",
"type": "progene_text",
"text": [
"Sequences required for induction of neurotensin receptor gene expression during neuronal differentiation of N1E-115 neuroblastoma cells ."
],
"offsets": [
[
0,
137
]
]
}
] |
[
{
"id": "split_0_train_6593_entity",
"type": "progene_text",
"text": [
"neurotensin receptor"
],
"offsets": [
[
36,
56
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4256
|
split_0_train_4256
|
[
{
"id": "split_0_train_4256_passage",
"type": "progene_text",
"text": [
"The promoter region of the mouse high affinity neurotensin receptor ( Ntr-1 ) gene was characterized , and sequences required for expression in neuroblastoma cell lines that express high affinity NT - binding sites were characterized ."
],
"offsets": [
[
0,
235
]
]
}
] |
[
{
"id": "split_0_train_6594_entity",
"type": "progene_text",
"text": [
"high affinity neurotensin receptor"
],
"offsets": [
[
33,
67
]
],
"normalized": []
},
{
"id": "split_0_train_6595_entity",
"type": "progene_text",
"text": [
"Ntr-1"
],
"offsets": [
[
70,
75
]
],
"normalized": []
},
{
"id": "split_0_train_6596_entity",
"type": "progene_text",
"text": [
"NT"
],
"offsets": [
[
196,
198
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4257
|
split_0_train_4257
|
[
{
"id": "split_0_train_4257_passage",
"type": "progene_text",
"text": [
"Me(2)SO - induced neuronal differentiation of N1E-115 neuroblastoma cells increased both the expression of the endogenous Ntr-1 gene and reporter genes driven by NTR-1 promoter sequences by 3-4 - fold ."
],
"offsets": [
[
0,
202
]
]
}
] |
[
{
"id": "split_0_train_6597_entity",
"type": "progene_text",
"text": [
"Ntr-1"
],
"offsets": [
[
122,
127
]
],
"normalized": []
},
{
"id": "split_0_train_6598_entity",
"type": "progene_text",
"text": [
"NTR-1"
],
"offsets": [
[
162,
167
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4258
|
split_0_train_4258
|
[
{
"id": "split_0_train_4258_passage",
"type": "progene_text",
"text": [
"Deletion analysis revealed that an 83 - base pair promoter region containing the transcriptional start site is required for Me(2) SO activation ."
],
"offsets": [
[
0,
145
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4259
|
split_0_train_4259
|
[
{
"id": "split_0_train_4259_passage",
"type": "progene_text",
"text": [
"Detailed mutational analysis of this region revealed that a CACCC box and the central region of a large GC - rich palindrome are the crucial cis - regulatory elements required for Me(2)SO induction ."
],
"offsets": [
[
0,
199
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4260
|
split_0_train_4260
|
[
{
"id": "split_0_train_4260_passage",
"type": "progene_text",
"text": [
"The CACCC box is bound by at least one factor that is induced upon Me(2)SO treatment of N1E-115 cells ."
],
"offsets": [
[
0,
103
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4261
|
split_0_train_4261
|
[
{
"id": "split_0_train_4261_passage",
"type": "progene_text",
"text": [
"The Me(2)SO effect was found to be both selective and cell type - restricted ."
],
"offsets": [
[
0,
78
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4262
|
split_0_train_4262
|
[
{
"id": "split_0_train_4262_passage",
"type": "progene_text",
"text": [
"Basal expression in the neuroblastoma cell lines required a distinct set of sequences , including an Sp1 - like sequence , and a sequence resembling an NGFI-A - binding site ; however , a more distal 5' sequence was found to repress basal activity in N1E-115 cells ."
],
"offsets": [
[
0,
266
]
]
}
] |
[
{
"id": "split_0_train_6599_entity",
"type": "progene_text",
"text": [
"Sp1"
],
"offsets": [
[
101,
104
]
],
"normalized": []
},
{
"id": "split_0_train_6600_entity",
"type": "progene_text",
"text": [
"NGFI-A"
],
"offsets": [
[
152,
158
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4263
|
split_0_train_4263
|
[
{
"id": "split_0_train_4263_passage",
"type": "progene_text",
"text": [
"These results provide evidence that Ntr-1 gene regulation involves both positive and negative regulatory elements located in the 5' - flanking region and that Ntr-1 gene activation involves the coordinate activation or induction of several factors , including a CACCC box binding complex ."
],
"offsets": [
[
0,
289
]
]
}
] |
[
{
"id": "split_0_train_6601_entity",
"type": "progene_text",
"text": [
"Ntr-1"
],
"offsets": [
[
36,
41
]
],
"normalized": []
},
{
"id": "split_0_train_6602_entity",
"type": "progene_text",
"text": [
"Ntr-1"
],
"offsets": [
[
159,
164
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4264
|
split_0_train_4264
|
[
{
"id": "split_0_train_4264_passage",
"type": "progene_text",
"text": [
"Members of the nuclear factor 1 transcription factor family regulate rat 3alpha-hydroxysteroid / dihydrodiol dehydrogenase ( 3alpha-HSD / DD AKR1C9 ) gene expression : a member of the aldo - keto reductase superfamily ."
],
"offsets": [
[
0,
219
]
]
}
] |
[
{
"id": "split_0_train_6603_entity",
"type": "progene_text",
"text": [
"nuclear factor 1 transcription factor family"
],
"offsets": [
[
15,
59
]
],
"normalized": []
},
{
"id": "split_0_train_6604_entity",
"type": "progene_text",
"text": [
"3alpha-hydroxysteroid / dihydrodiol dehydrogenase"
],
"offsets": [
[
73,
122
]
],
"normalized": []
},
{
"id": "split_0_train_6605_entity",
"type": "progene_text",
"text": [
"3alpha-HSD"
],
"offsets": [
[
125,
135
]
],
"normalized": []
},
{
"id": "split_0_train_6606_entity",
"type": "progene_text",
"text": [
"AKR1C9"
],
"offsets": [
[
141,
147
]
],
"normalized": []
},
{
"id": "split_0_train_6607_entity",
"type": "progene_text",
"text": [
"aldo - keto reductase superfamily"
],
"offsets": [
[
184,
217
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4265
|
split_0_train_4265
|
[
{
"id": "split_0_train_4265_passage",
"type": "progene_text",
"text": [
"Rat 3alpha-hydroxysteroid / dihydrodiol dehydrogenase ( 3alpha-HSD / DD ; AKR1C9 ) , a member of the aldo - keto reductase ( AKR ) superfamily , inactivates nearly all steroid hormones by converting 5alpha - and 5beta-dihydrosteroids to their respective 3alpha,5alpha - and 3alpha,5beta - tetrahydrosteroids and protects against circulating steroid hormone excess ."
],
"offsets": [
[
0,
365
]
]
}
] |
[
{
"id": "split_0_train_6608_entity",
"type": "progene_text",
"text": [
"3alpha-hydroxysteroid / dihydrodiol dehydrogenase"
],
"offsets": [
[
4,
53
]
],
"normalized": []
},
{
"id": "split_0_train_6609_entity",
"type": "progene_text",
"text": [
"3alpha-HSD"
],
"offsets": [
[
56,
66
]
],
"normalized": []
},
{
"id": "split_0_train_6610_entity",
"type": "progene_text",
"text": [
"AKR1C9"
],
"offsets": [
[
74,
80
]
],
"normalized": []
},
{
"id": "split_0_train_6611_entity",
"type": "progene_text",
"text": [
"aldo - keto reductase ( AKR ) superfamily"
],
"offsets": [
[
101,
142
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4266
|
split_0_train_4266
|
[
{
"id": "split_0_train_4266_passage",
"type": "progene_text",
"text": [
"It is highly expressed in rat liver comprising 0.5 - 1.0 % of the soluble protein ."
],
"offsets": [
[
0,
83
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4267
|
split_0_train_4267
|
[
{
"id": "split_0_train_4267_passage",
"type": "progene_text",
"text": [
"Previously , we identified a powerful distal enhancer resident at about - 4.0 kb to - 2.0 kb in the 5' - flanking region of the 3alpha-HSD / DD gene ."
],
"offsets": [
[
0,
150
]
]
}
] |
[
{
"id": "split_0_train_6612_entity",
"type": "progene_text",
"text": [
"3alpha-HSD"
],
"offsets": [
[
128,
138
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4268
|
split_0_train_4268
|
[
{
"id": "split_0_train_4268_passage",
"type": "progene_text",
"text": [
"We now report the functional dissection of this enhancer ."
],
"offsets": [
[
0,
58
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4269
|
split_0_train_4269
|
[
{
"id": "split_0_train_4269_passage",
"type": "progene_text",
"text": [
"Transfection of nested deletions of the 5'-end of the gene promoter linked to chloramphenicol acetyltransferase ( CAT ) into HepG2 cells located the enhancer activity between (-4673 to - 4179 bp ) ."
],
"offsets": [
[
0,
198
]
]
}
] |
[
{
"id": "split_0_train_6613_entity",
"type": "progene_text",
"text": [
"chloramphenicol acetyltransferase"
],
"offsets": [
[
78,
111
]
],
"normalized": []
},
{
"id": "split_0_train_6614_entity",
"type": "progene_text",
"text": [
"CAT"
],
"offsets": [
[
114,
117
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4270
|
split_0_train_4270
|
[
{
"id": "split_0_train_4270_passage",
"type": "progene_text",
"text": [
"Further internal and 5'-end deletion mutants revealed that a 73 - bp fragment ( from - 4351 to - 4279 bp ) contained a major enhancer element ."
],
"offsets": [
[
0,
143
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4271
|
split_0_train_4271
|
[
{
"id": "split_0_train_4271_passage",
"type": "progene_text",
"text": [
"This fragment spanned two imperfect direct repeats GTGGAAAAACCCAGGAA and GTGGAAAAAACCCAGGAA and contained three direct repeats of GGAAAAA ."
],
"offsets": [
[
0,
139
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4272
|
split_0_train_4272
|
[
{
"id": "split_0_train_4272_passage",
"type": "progene_text",
"text": [
"This fragment also contained three potential half - nuclear factor 1 ( NF1 ) sites ( TGGA - NNNNNGCCA ) and a putative CCAAT - enhancer binding protein ( C / EBP ) binding site ."
],
"offsets": [
[
0,
178
]
]
}
] |
[
{
"id": "split_0_train_6615_entity",
"type": "progene_text",
"text": [
"nuclear factor 1"
],
"offsets": [
[
52,
68
]
],
"normalized": []
},
{
"id": "split_0_train_6616_entity",
"type": "progene_text",
"text": [
"NF1"
],
"offsets": [
[
71,
74
]
],
"normalized": []
},
{
"id": "split_0_train_6617_entity",
"type": "progene_text",
"text": [
"CCAAT - enhancer binding protein"
],
"offsets": [
[
119,
151
]
],
"normalized": []
},
{
"id": "split_0_train_6618_entity",
"type": "progene_text",
"text": [
"C / EBP"
],
"offsets": [
[
154,
161
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4273
|
split_0_train_4273
|
[
{
"id": "split_0_train_4273_passage",
"type": "progene_text",
"text": [
"The 73 - bp fragment enhanced CAT activity from the basal 3alpha-HSD / DD gene promoter ."
],
"offsets": [
[
0,
89
]
]
}
] |
[
{
"id": "split_0_train_6619_entity",
"type": "progene_text",
"text": [
"CAT"
],
"offsets": [
[
30,
33
]
],
"normalized": []
},
{
"id": "split_0_train_6620_entity",
"type": "progene_text",
"text": [
"3alpha-HSD"
],
"offsets": [
[
58,
68
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4274
|
split_0_train_4274
|
[
{
"id": "split_0_train_4274_passage",
"type": "progene_text",
"text": [
"Recombinant C / EBPalpha and C / EBPbeta did not bind to this fragment ."
],
"offsets": [
[
0,
72
]
]
}
] |
[
{
"id": "split_0_train_6621_entity",
"type": "progene_text",
"text": [
"C / EBPalpha"
],
"offsets": [
[
12,
24
]
],
"normalized": []
},
{
"id": "split_0_train_6622_entity",
"type": "progene_text",
"text": [
"C / EBPbeta"
],
"offsets": [
[
29,
40
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4275
|
split_0_train_4275
|
[
{
"id": "split_0_train_4275_passage",
"type": "progene_text",
"text": [
"Electrophoretic mobility shift assays showed that HepG2 and rat liver nuclear extracts bound to this 73 - bp fragment ."
],
"offsets": [
[
0,
119
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4276
|
split_0_train_4276
|
[
{
"id": "split_0_train_4276_passage",
"type": "progene_text",
"text": [
"The 73 - bp protein complex was competed out by a NF1 oligonucleotide and was supershifted by an NF1 antibody ."
],
"offsets": [
[
0,
111
]
]
}
] |
[
{
"id": "split_0_train_6623_entity",
"type": "progene_text",
"text": [
"NF1"
],
"offsets": [
[
50,
53
]
],
"normalized": []
},
{
"id": "split_0_train_6624_entity",
"type": "progene_text",
"text": [
"NF1"
],
"offsets": [
[
97,
100
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4277
|
split_0_train_4277
|
[
{
"id": "split_0_train_4277_passage",
"type": "progene_text",
"text": [
"When the 73 - bp fragment was fused to an alpha1 - globin promoter - CAT construct and cotransfected with CCAAT transcription factor 1 ( CTF1 ) / NF1 into Drosophila Schneider SL2 insect cells ( which lack NF1 - like proteins ) trans - activation of CAT activity was observed ."
],
"offsets": [
[
0,
277
]
]
}
] |
[
{
"id": "split_0_train_6625_entity",
"type": "progene_text",
"text": [
"alpha1 - globin"
],
"offsets": [
[
42,
57
]
],
"normalized": []
},
{
"id": "split_0_train_6626_entity",
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250,
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] |
[] |
[] |
[] |
split_0_train_4278
|
split_0_train_4278
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"3alpha-HSD"
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124,
134
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}
] |
[] |
[] |
[] |
split_0_train_4279
|
split_0_train_4279
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46,
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] |
[] |
[] |
[] |
split_0_train_4280
|
split_0_train_4280
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216
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] |
[] |
[] |
[] |
split_0_train_4281
|
split_0_train_4281
|
[
{
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"type": "progene_text",
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"We recently showed that the antiapoptotic function of insulin requires nuclear factor kappaB ( NF-kappaB ) activation ( Bertrand , F. , Atfi , A. , Cadoret , A. , L'Allemain , G. , Robin , H. , Lascols , O. , Capeau , J. , and Cherqui , G. ( 1998 ) J. Biol. Chem. 273 , 2931 - 2938 ) ."
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"text": [
"NF-kappaB"
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95,
104
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}
] |
[] |
[] |
[] |
split_0_train_4282
|
split_0_train_4282
|
[
{
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"type": "progene_text",
"text": [
"Here we sought to identify the NF-kappaB - dependent survival genes that are activated by insulin to mediate this function ."
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0,
124
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}
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{
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"text": [
"insulin"
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"offsets": [
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90,
97
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}
] |
[] |
[] |
[] |
split_0_train_4283
|
split_0_train_4283
|
[
{
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"text": [
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189
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"text": [
"IRs"
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182,
185
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}
] |
[] |
[] |
[] |
split_0_train_4284
|
split_0_train_4284
|
[
{
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"type": "progene_text",
"text": [
"This effect required (i) IR activation since it was abrogated by IR mutation at tyrosines 1162 and 1163 and (ii) NF-kappaB activation since it was abolished by overexpression of dominant - negative IkappaB-alpha ( A32 / 36 ) and mimicked by overexpression of the NF-kappaB c-Rel subunit ."
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288
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"text": [
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273,
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}
] |
[] |
[] |
[] |
split_0_train_4285
|
split_0_train_4285
|
[
{
"id": "split_0_train_4285_passage",
"type": "progene_text",
"text": [
"TRAF2 contributed to insulin protection against serum withdrawal - induced apoptosis since TRAF2 overexpression mimicked insulin protection , whereas overexpression of dominant - negative TRAF2 -(87-501 ) reduced this process ."
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0,
227
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}
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{
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"TRAF2"
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[
188,
193
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}
] |
[] |
[] |
[] |
split_0_train_4286
|
split_0_train_4286
|
[
{
"id": "split_0_train_4286_passage",
"type": "progene_text",
"text": [
"Along with its protective effect , overexpressed TRAF2 increased basal and insulin - stimulated NF-kappaB activities ."
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118
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}
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{
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"text": [
"NF-kappaB"
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96,
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}
] |
[] |
[] |
[] |
split_0_train_4287
|
split_0_train_4287
|
[
{
"id": "split_0_train_4287_passage",
"type": "progene_text",
"text": [
"All effects were inhibited by IkappaB-alpha ( A32/36 ) , suggesting that an amplification loop involving TRAF2 activation of NF-kappaB is implicated in insulin antiapoptotic signaling ."
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[
0,
185
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}
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[
{
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"text": [
"NF-kappaB"
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"offsets": [
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125,
134
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}
] |
[] |
[] |
[] |
split_0_train_4288
|
split_0_train_4288
|
[
{
"id": "split_0_train_4288_passage",
"type": "progene_text",
"text": [
"We also show that insulin increased manganese - superoxide dismutase ( Mn-SOD ) mRNA expression through NF-kappaB activation and that Mn-SOD contributed to insulin antiapoptotic signaling since expression of antisense Mn-SOD RNA decreased this process ."
],
"offsets": [
[
0,
253
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]
}
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"text": [
"Mn-SOD"
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"offsets": [
[
218,
224
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4289
|
split_0_train_4289
|
[
{
"id": "split_0_train_4289_passage",
"type": "progene_text",
"text": [
"This study provides the first evidence that insulin activates the NF-kappaB - dependent survival genes encoding TRAF2 and Mn-SOD and thereby clarifies the role of NF-kappaB in the antiapoptotic function of insulin ."
],
"offsets": [
[
0,
215
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}
] |
[
{
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"type": "progene_text",
"text": [
"insulin"
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"offsets": [
[
206,
213
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4290
|
split_0_train_4290
|
[
{
"id": "split_0_train_4290_passage",
"type": "progene_text",
"text": [
"CHOP enhancement of gene transcription by interactions with Jun / Fos AP-1 complex proteins ."
],
"offsets": [
[
0,
93
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]
}
] |
[
{
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{
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{
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"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
70,
74
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4291
|
split_0_train_4291
|
[
{
"id": "split_0_train_4291_passage",
"type": "progene_text",
"text": [
"The transcription factor CHOP ( C / EBP homologous protein 10 ) is a bZIP protein induced by a variety of stimuli that evoke cellular stress responses and has been shown to arrest cell growth and to promote programmed cell death ."
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"offsets": [
[
0,
230
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]
}
] |
[
{
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"type": "progene_text",
"text": [
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4,
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{
"id": "split_0_train_6684_entity",
"type": "progene_text",
"text": [
"CHOP"
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25,
29
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{
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"text": [
"C / EBP homologous protein 10"
],
"offsets": [
[
32,
61
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4292
|
split_0_train_4292
|
[
{
"id": "split_0_train_4292_passage",
"type": "progene_text",
"text": [
"CHOP cannot form homodimers but forms stable heterodimers with the C / EBP family of activating transcription factors ."
],
"offsets": [
[
0,
119
]
]
}
] |
[
{
"id": "split_0_train_6686_entity",
"type": "progene_text",
"text": [
"CHOP"
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[
0,
4
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},
{
"id": "split_0_train_6687_entity",
"type": "progene_text",
"text": [
"C / EBP family"
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67,
81
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{
"id": "split_0_train_6688_entity",
"type": "progene_text",
"text": [
"activating transcription factors"
],
"offsets": [
[
85,
117
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4293
|
split_0_train_4293
|
[
{
"id": "split_0_train_4293_passage",
"type": "progene_text",
"text": [
"Although initially characterized as a dominant negative inhibitor of C / EBPs in the activation of gene transcription , CHOP - C / EBP can activate certain target genes ."
],
"offsets": [
[
0,
170
]
]
}
] |
[
{
"id": "split_0_train_6689_entity",
"type": "progene_text",
"text": [
"C / EBPs"
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"offsets": [
[
69,
77
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},
{
"id": "split_0_train_6690_entity",
"type": "progene_text",
"text": [
"CHOP"
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[
120,
124
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},
{
"id": "split_0_train_6691_entity",
"type": "progene_text",
"text": [
"C / EBP"
],
"offsets": [
[
127,
134
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4294
|
split_0_train_4294
|
[
{
"id": "split_0_train_4294_passage",
"type": "progene_text",
"text": [
"Here we show that CHOP interacts with members of the immediate - early response , growth - promoting AP-1 transcription factor family , JunD , c-Jun , and c-Fos , to activate promoter elements in the somatostatin , JunD , and collagenase genes ."
],
"offsets": [
[
0,
245
]
]
}
] |
[
{
"id": "split_0_train_6692_entity",
"type": "progene_text",
"text": [
"CHOP"
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"offsets": [
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18,
22
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{
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"text": [
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101,
133
]
],
"normalized": []
},
{
"id": "split_0_train_6694_entity",
"type": "progene_text",
"text": [
"JunD"
],
"offsets": [
[
136,
140
]
],
"normalized": []
},
{
"id": "split_0_train_6695_entity",
"type": "progene_text",
"text": [
"c-Jun"
],
"offsets": [
[
143,
148
]
],
"normalized": []
},
{
"id": "split_0_train_6696_entity",
"type": "progene_text",
"text": [
"c-Fos"
],
"offsets": [
[
155,
160
]
],
"normalized": []
},
{
"id": "split_0_train_6697_entity",
"type": "progene_text",
"text": [
"somatostatin"
],
"offsets": [
[
200,
212
]
],
"normalized": []
},
{
"id": "split_0_train_6698_entity",
"type": "progene_text",
"text": [
"JunD"
],
"offsets": [
[
215,
219
]
],
"normalized": []
},
{
"id": "split_0_train_6699_entity",
"type": "progene_text",
"text": [
"collagenase"
],
"offsets": [
[
226,
237
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4295
|
split_0_train_4295
|
[
{
"id": "split_0_train_4295_passage",
"type": "progene_text",
"text": [
"The leucine zipper dimerization domain is required for interactions with AP-1 proteins and transactivation of transcription ."
],
"offsets": [
[
0,
125
]
]
}
] |
[
{
"id": "split_0_train_6700_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
73,
77
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4296
|
split_0_train_4296
|
[
{
"id": "split_0_train_4296_passage",
"type": "progene_text",
"text": [
"Analyses by electrophoretic mobility shift assays and by an in vivo mammalian two - hybrid system for protein - protein interactions indicate that CHOP interacts with AP-1 proteins inside cells and suggest that it is recruited to the AP-1 complex by a tethering mechanism rather than by direct binding of DNA ."
],
"offsets": [
[
0,
310
]
]
}
] |
[
{
"id": "split_0_train_6701_entity",
"type": "progene_text",
"text": [
"CHOP"
],
"offsets": [
[
147,
151
]
],
"normalized": []
},
{
"id": "split_0_train_6702_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
167,
171
]
],
"normalized": []
},
{
"id": "split_0_train_6703_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
234,
238
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4297
|
split_0_train_4297
|
[
{
"id": "split_0_train_4297_passage",
"type": "progene_text",
"text": [
"Thus , CHOP not only is a negative or a positive regulator of C / EBP target genes but also , when tethered to AP-1 factors , can activate AP-1 target genes ."
],
"offsets": [
[
0,
158
]
]
}
] |
[
{
"id": "split_0_train_6704_entity",
"type": "progene_text",
"text": [
"CHOP"
],
"offsets": [
[
7,
11
]
],
"normalized": []
},
{
"id": "split_0_train_6705_entity",
"type": "progene_text",
"text": [
"C / EBP"
],
"offsets": [
[
62,
69
]
],
"normalized": []
},
{
"id": "split_0_train_6706_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
111,
115
]
],
"normalized": []
},
{
"id": "split_0_train_6707_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
139,
143
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4298
|
split_0_train_4298
|
[
{
"id": "split_0_train_4298_passage",
"type": "progene_text",
"text": [
"These findings establish the existence of a new mechanism by which CHOP regulates gene expression when cells are exposed to cellular stress ."
],
"offsets": [
[
0,
141
]
]
}
] |
[
{
"id": "split_0_train_6708_entity",
"type": "progene_text",
"text": [
"CHOP"
],
"offsets": [
[
67,
71
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4299
|
split_0_train_4299
|
[
{
"id": "split_0_train_4299_passage",
"type": "progene_text",
"text": [
"The AL-R8 SI : the next generation staging container for plutonium pits at the USDOE Pantex Plant ."
],
"offsets": [
[
0,
99
]
]
}
] |
[] |
[] |
[] |
[] |
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