id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_4000
|
split_0_train_4000
|
[
{
"id": "split_0_train_4000_passage",
"type": "progene_text",
"text": [
"To assess this , we converted TraR into a repressor by placing a copy of the tra box , an 18 - bp inverted repeat believed to be the recognition site for this protein , over the - 10 region of a promoter driving expression of lacZ ."
],
"offsets": [
[
0,
232
]
]
}
] |
[
{
"id": "split_0_train_6298_entity",
"type": "progene_text",
"text": [
"TraR"
],
"offsets": [
[
30,
34
]
],
"normalized": []
},
{
"id": "split_0_train_6299_entity",
"type": "progene_text",
"text": [
"tra"
],
"offsets": [
[
77,
80
]
],
"normalized": []
},
{
"id": "split_0_train_6300_entity",
"type": "progene_text",
"text": [
"lacZ"
],
"offsets": [
[
226,
230
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4001
|
split_0_train_4001
|
[
{
"id": "split_0_train_4001_passage",
"type": "progene_text",
"text": [
"Repression of this promoter by TraR depended on AAI or , at higher concentrations , VAI , the closely related signal of Vibrio fischeri ."
],
"offsets": [
[
0,
137
]
]
}
] |
[
{
"id": "split_0_train_6301_entity",
"type": "progene_text",
"text": [
"TraR"
],
"offsets": [
[
31,
35
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4002
|
split_0_train_4002
|
[
{
"id": "split_0_train_4002_passage",
"type": "progene_text",
"text": [
"C - terminal deletions as short as 2 aa and N - terminal deletions as short as 4 aa in TraR abolished both repressor and activator functions ."
],
"offsets": [
[
0,
142
]
]
}
] |
[
{
"id": "split_0_train_6302_entity",
"type": "progene_text",
"text": [
"TraR"
],
"offsets": [
[
87,
91
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4003
|
split_0_train_4003
|
[
{
"id": "split_0_train_4003_passage",
"type": "progene_text",
"text": [
"The C - terminal mutants were strongly dominant over TraR , suggesting that they can form heteromultimers with the wild - type activator ."
],
"offsets": [
[
0,
138
]
]
}
] |
[
{
"id": "split_0_train_6303_entity",
"type": "progene_text",
"text": [
"TraR"
],
"offsets": [
[
53,
57
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4004
|
split_0_train_4004
|
[
{
"id": "split_0_train_4004_passage",
"type": "progene_text",
"text": [
"Mutants of TraR with substitutions at Asp - 10 and Gly-123 failed to activate a positively controlled reporter but continued to repress the chimeric promoter in an AAI - dependent manner ."
],
"offsets": [
[
0,
188
]
]
}
] |
[
{
"id": "split_0_train_6304_entity",
"type": "progene_text",
"text": [
"TraR"
],
"offsets": [
[
11,
15
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4005
|
split_0_train_4005
|
[
{
"id": "split_0_train_4005_passage",
"type": "progene_text",
"text": [
"We conclude that TraR recognizes the tra box as its binding site , that binding of TraR to this site depends on AAI , and that the N - terminal half of the protein contains one or more domains that are required for activation but not for multimerization , for interaction with the acyl - homoserine lactone , or for DNA binding ."
],
"offsets": [
[
0,
329
]
]
}
] |
[
{
"id": "split_0_train_6305_entity",
"type": "progene_text",
"text": [
"TraR"
],
"offsets": [
[
17,
21
]
],
"normalized": []
},
{
"id": "split_0_train_6306_entity",
"type": "progene_text",
"text": [
"TraR"
],
"offsets": [
[
83,
87
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4006
|
split_0_train_4006
|
[
{
"id": "split_0_train_4006_passage",
"type": "progene_text",
"text": [
"The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins ."
],
"offsets": [
[
0,
103
]
]
}
] |
[
{
"id": "split_0_train_6307_entity",
"type": "progene_text",
"text": [
"Mad1"
],
"offsets": [
[
79,
83
]
],
"normalized": []
},
{
"id": "split_0_train_6308_entity",
"type": "progene_text",
"text": [
"Mad2"
],
"offsets": [
[
88,
92
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4007
|
split_0_train_4007
|
[
{
"id": "split_0_train_4007_passage",
"type": "progene_text",
"text": [
"The spindle checkpoint arrests the cell cycle at metaphase in the presence of defects in the mitotic spindle or in the attachment of chromosomes to the spindle ."
],
"offsets": [
[
0,
161
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4008
|
split_0_train_4008
|
[
{
"id": "split_0_train_4008_passage",
"type": "progene_text",
"text": [
"When spindle assembly is disrupted , the budding yeast mad and bub mutants fail to arrest and rapidly lose viability ."
],
"offsets": [
[
0,
118
]
]
}
] |
[
{
"id": "split_0_train_6309_entity",
"type": "progene_text",
"text": [
"mad"
],
"offsets": [
[
55,
58
]
],
"normalized": []
},
{
"id": "split_0_train_6310_entity",
"type": "progene_text",
"text": [
"bub"
],
"offsets": [
[
63,
66
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4009
|
split_0_train_4009
|
[
{
"id": "split_0_train_4009_passage",
"type": "progene_text",
"text": [
"We have cloned the MAD2 gene , which encodes a protein of 196 amino acids that remains at a constant level during the cell cycle ."
],
"offsets": [
[
0,
130
]
]
}
] |
[
{
"id": "split_0_train_6311_entity",
"type": "progene_text",
"text": [
"MAD2"
],
"offsets": [
[
19,
23
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4010
|
split_0_train_4010
|
[
{
"id": "split_0_train_4010_passage",
"type": "progene_text",
"text": [
"Gel filtration and co - immunoprecipitation analyses reveal that Mad2p tightly associates with another spindle checkpoint component , Mad1p ."
],
"offsets": [
[
0,
141
]
]
}
] |
[
{
"id": "split_0_train_6312_entity",
"type": "progene_text",
"text": [
"Mad2p"
],
"offsets": [
[
65,
70
]
],
"normalized": []
},
{
"id": "split_0_train_6313_entity",
"type": "progene_text",
"text": [
"Mad1p"
],
"offsets": [
[
134,
139
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4011
|
split_0_train_4011
|
[
{
"id": "split_0_train_4011_passage",
"type": "progene_text",
"text": [
"This association is independent of cell cycle stage and the presence or absence of other known checkpoint proteins ."
],
"offsets": [
[
0,
116
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4012
|
split_0_train_4012
|
[
{
"id": "split_0_train_4012_passage",
"type": "progene_text",
"text": [
"In addition , Mad2p binds to all of the different phosphorylated isoforms of Mad1p that can be resolved on SDS-PAGE ."
],
"offsets": [
[
0,
117
]
]
}
] |
[
{
"id": "split_0_train_6314_entity",
"type": "progene_text",
"text": [
"Mad2p"
],
"offsets": [
[
14,
19
]
],
"normalized": []
},
{
"id": "split_0_train_6315_entity",
"type": "progene_text",
"text": [
"Mad1p"
],
"offsets": [
[
77,
82
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4013
|
split_0_train_4013
|
[
{
"id": "split_0_train_4013_passage",
"type": "progene_text",
"text": [
"Deletion and mutational analysis of both proteins indicate that association of Mad2p with Mad1p is critical for checkpoint function and for hyperphosphorylation of Mad1p ."
],
"offsets": [
[
0,
171
]
]
}
] |
[
{
"id": "split_0_train_6316_entity",
"type": "progene_text",
"text": [
"Mad2p"
],
"offsets": [
[
79,
84
]
],
"normalized": []
},
{
"id": "split_0_train_6317_entity",
"type": "progene_text",
"text": [
"Mad1p"
],
"offsets": [
[
90,
95
]
],
"normalized": []
},
{
"id": "split_0_train_6318_entity",
"type": "progene_text",
"text": [
"Mad1p"
],
"offsets": [
[
164,
169
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4014
|
split_0_train_4014
|
[
{
"id": "split_0_train_4014_passage",
"type": "progene_text",
"text": [
"Differential expression of Myc1 and Myc2 isoforms in cells transformed by eIF4E : evidence for internal ribosome repositioning in the human c-myc 5'UTR ."
],
"offsets": [
[
0,
153
]
]
}
] |
[
{
"id": "split_0_train_6319_entity",
"type": "progene_text",
"text": [
"Myc1"
],
"offsets": [
[
27,
31
]
],
"normalized": []
},
{
"id": "split_0_train_6320_entity",
"type": "progene_text",
"text": [
"Myc2"
],
"offsets": [
[
36,
40
]
],
"normalized": []
},
{
"id": "split_0_train_6321_entity",
"type": "progene_text",
"text": [
"eIF4E"
],
"offsets": [
[
74,
79
]
],
"normalized": []
},
{
"id": "split_0_train_6322_entity",
"type": "progene_text",
"text": [
"c-myc"
],
"offsets": [
[
140,
145
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4015
|
split_0_train_4015
|
[
{
"id": "split_0_train_4015_passage",
"type": "progene_text",
"text": [
"eIF4E is essential for translation initiation , but its overexpression causes malignant transformation ."
],
"offsets": [
[
0,
104
]
]
}
] |
[
{
"id": "split_0_train_6323_entity",
"type": "progene_text",
"text": [
"eIF4E"
],
"offsets": [
[
0,
5
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4016
|
split_0_train_4016
|
[
{
"id": "split_0_train_4016_passage",
"type": "progene_text",
"text": [
"Recent work demonstrated that eIF4E / F participates in exposing and locating alternate translation start codons during scanning ."
],
"offsets": [
[
0,
130
]
]
}
] |
[
{
"id": "split_0_train_6324_entity",
"type": "progene_text",
"text": [
"eIF4E"
],
"offsets": [
[
30,
35
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4017
|
split_0_train_4017
|
[
{
"id": "split_0_train_4017_passage",
"type": "progene_text",
"text": [
"Translation initiation of several important protooncogenes and growth - regulators , such as Myc and FGF-2 , can start at CUG start codon(s) upstream of the normal open reading frame ( ORF ) ."
],
"offsets": [
[
0,
192
]
]
}
] |
[
{
"id": "split_0_train_6325_entity",
"type": "progene_text",
"text": [
"Myc"
],
"offsets": [
[
93,
96
]
],
"normalized": []
},
{
"id": "split_0_train_6326_entity",
"type": "progene_text",
"text": [
"FGF-2"
],
"offsets": [
[
101,
106
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4018
|
split_0_train_4018
|
[
{
"id": "split_0_train_4018_passage",
"type": "progene_text",
"text": [
"The resulting amino - terminal extension alters the properties of these proteins and their intracellular distribution ."
],
"offsets": [
[
0,
119
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4019
|
split_0_train_4019
|
[
{
"id": "split_0_train_4019_passage",
"type": "progene_text",
"text": [
"In cells overexpressing eIF4E , c-myc is overexpressed and particularly the larger , CUG-initiated form ( Myc1 ) ."
],
"offsets": [
[
0,
114
]
]
}
] |
[
{
"id": "split_0_train_6327_entity",
"type": "progene_text",
"text": [
"eIF4E"
],
"offsets": [
[
24,
29
]
],
"normalized": []
},
{
"id": "split_0_train_6328_entity",
"type": "progene_text",
"text": [
"c-myc"
],
"offsets": [
[
32,
37
]
],
"normalized": []
},
{
"id": "split_0_train_6329_entity",
"type": "progene_text",
"text": [
"Myc1"
],
"offsets": [
[
106,
110
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4020
|
split_0_train_4020
|
[
{
"id": "split_0_train_4020_passage",
"type": "progene_text",
"text": [
"Recent reports suggest that synthesis of Myc2 , the normally expressed AUG - initiated form , is mediated by an IRES ."
],
"offsets": [
[
0,
118
]
]
}
] |
[
{
"id": "split_0_train_6330_entity",
"type": "progene_text",
"text": [
"Myc2"
],
"offsets": [
[
41,
45
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4021
|
split_0_train_4021
|
[
{
"id": "split_0_train_4021_passage",
"type": "progene_text",
"text": [
"To determine what role eIF4E might play in c-myc expression , the c-myc 5' untranslated region ( UTR ) was fused in - frame to CAT reporters , and several more derivative constructs were made ."
],
"offsets": [
[
0,
193
]
]
}
] |
[
{
"id": "split_0_train_6331_entity",
"type": "progene_text",
"text": [
"eIF4E"
],
"offsets": [
[
23,
28
]
],
"normalized": []
},
{
"id": "split_0_train_6332_entity",
"type": "progene_text",
"text": [
"c-myc"
],
"offsets": [
[
43,
48
]
],
"normalized": []
},
{
"id": "split_0_train_6333_entity",
"type": "progene_text",
"text": [
"c-myc"
],
"offsets": [
[
66,
71
]
],
"normalized": []
},
{
"id": "split_0_train_6334_entity",
"type": "progene_text",
"text": [
"CAT"
],
"offsets": [
[
127,
130
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4022
|
split_0_train_4022
|
[
{
"id": "split_0_train_4022_passage",
"type": "progene_text",
"text": [
"In vitro translation experiments ( with and without eIF4E / F ) ; expression in CHO cells transformed with eIF4E ; and deletion / mutation analysis demonstrated that Myc1 is translated by a scanning mechanism , while Myc2 is translated by Internal Ribosome Repositioning ."
],
"offsets": [
[
0,
272
]
]
}
] |
[
{
"id": "split_0_train_6335_entity",
"type": "progene_text",
"text": [
"eIF4E"
],
"offsets": [
[
52,
57
]
],
"normalized": []
},
{
"id": "split_0_train_6336_entity",
"type": "progene_text",
"text": [
"eIF4E"
],
"offsets": [
[
107,
112
]
],
"normalized": []
},
{
"id": "split_0_train_6337_entity",
"type": "progene_text",
"text": [
"Myc1"
],
"offsets": [
[
166,
170
]
],
"normalized": []
},
{
"id": "split_0_train_6338_entity",
"type": "progene_text",
"text": [
"Myc2"
],
"offsets": [
[
217,
221
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4023
|
split_0_train_4023
|
[
{
"id": "split_0_train_4023_passage",
"type": "progene_text",
"text": [
"Moreover , the existence of a true IRES in the 5'UTR was contradicted by its failure to direct translation of a circular transcript , in contrast to hsp70 ."
],
"offsets": [
[
0,
156
]
]
}
] |
[
{
"id": "split_0_train_6339_entity",
"type": "progene_text",
"text": [
"hsp70"
],
"offsets": [
[
149,
154
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4024
|
split_0_train_4024
|
[
{
"id": "split_0_train_4024_passage",
"type": "progene_text",
"text": [
"The c-myc 5' UTR also failed to engage in translation in the absence of functional eIF4F , after cleavage of the eIF4G component with CVB4 protease-2A ."
],
"offsets": [
[
0,
152
]
]
}
] |
[
{
"id": "split_0_train_6340_entity",
"type": "progene_text",
"text": [
"c-myc"
],
"offsets": [
[
4,
9
]
],
"normalized": []
},
{
"id": "split_0_train_6341_entity",
"type": "progene_text",
"text": [
"eIF4F"
],
"offsets": [
[
83,
88
]
],
"normalized": []
},
{
"id": "split_0_train_6342_entity",
"type": "progene_text",
"text": [
"eIF4G"
],
"offsets": [
[
113,
118
]
],
"normalized": []
},
{
"id": "split_0_train_6343_entity",
"type": "progene_text",
"text": [
"protease-2A"
],
"offsets": [
[
139,
150
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4025
|
split_0_train_4025
|
[
{
"id": "split_0_train_4025_passage",
"type": "progene_text",
"text": [
"The Internal Repositioning Element ( IRPE ) in c-myc 5'UTR was delimited to nucleotides ( nt ) 394 - 440 from the P1 transcription start site ."
],
"offsets": [
[
0,
143
]
]
}
] |
[
{
"id": "split_0_train_6344_entity",
"type": "progene_text",
"text": [
"c-myc"
],
"offsets": [
[
47,
52
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4026
|
split_0_train_4026
|
[
{
"id": "split_0_train_4026_passage",
"type": "progene_text",
"text": [
"Subchronic inhalation study of 1-hexene in Fischer 344 rats ."
],
"offsets": [
[
0,
61
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4027
|
split_0_train_4027
|
[
{
"id": "split_0_train_4027_passage",
"type": "progene_text",
"text": [
"The objective of this study was to evaluate the toxicity of 1-hexene following repeated inhalation exposures in male and female Fischer 344 rats ."
],
"offsets": [
[
0,
146
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4028
|
split_0_train_4028
|
[
{
"id": "split_0_train_4028_passage",
"type": "progene_text",
"text": [
"Groups of 40 male and 40 female rats were exposed for 6 hours per day , 5 days per week , over a 13 - week period ."
],
"offsets": [
[
0,
115
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4029
|
split_0_train_4029
|
[
{
"id": "split_0_train_4029_passage",
"type": "progene_text",
"text": [
"Treatment groups consisted of air - exposed control ( 0 ppm ) and three test groups of 300 , 1000 , and 3000 ppm 1 - hexene ."
],
"offsets": [
[
0,
125
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4030
|
split_0_train_4030
|
[
{
"id": "split_0_train_4030_passage",
"type": "progene_text",
"text": [
"During the treatment period , the rats were observed daily for clinical signs of toxicity ; body weights and neuromuscular coordination [ females only ] were measured at 7 - day intervals ."
],
"offsets": [
[
0,
189
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4031
|
split_0_train_4031
|
[
{
"id": "split_0_train_4031_passage",
"type": "progene_text",
"text": [
"After 7 weeks of exposure and at the end of the treatment period , the rats were subject to macroscopic and microscopic pathology , clinical chemistry , hematology , urinalysis , and sperm counts ."
],
"offsets": [
[
0,
197
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4032
|
split_0_train_4032
|
[
{
"id": "split_0_train_4032_passage",
"type": "progene_text",
"text": [
"No mortalities were observed during the course of the study ."
],
"offsets": [
[
0,
61
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4033
|
split_0_train_4033
|
[
{
"id": "split_0_train_4033_passage",
"type": "progene_text",
"text": [
"No clinical signs of toxicity attributable to 1-hexene exposure were observed ."
],
"offsets": [
[
0,
79
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4034
|
split_0_train_4034
|
[
{
"id": "split_0_train_4034_passage",
"type": "progene_text",
"text": [
"Female rats exposed to 3000 ppm had significantly lower body weights compared to control rats from exposure day 5 persisting throughout the treatment period ."
],
"offsets": [
[
0,
158
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4035
|
split_0_train_4035
|
[
{
"id": "split_0_train_4035_passage",
"type": "progene_text",
"text": [
"Male rats exposed to 3000 ppm had slightly but not statistically significant lower body weights in comparison to controls ."
],
"offsets": [
[
0,
123
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4036
|
split_0_train_4036
|
[
{
"id": "split_0_train_4036_passage",
"type": "progene_text",
"text": [
"Male rats exhibited slightly increased absolute and relative testicular weights , and female rats had slightly decreased absolute [ but not relative ] liver and kidney weights , at 3000 ppm ."
],
"offsets": [
[
0,
191
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4037
|
split_0_train_4037
|
[
{
"id": "split_0_train_4037_passage",
"type": "progene_text",
"text": [
"There were no gross or microscopic morphological findings attributed to treatment ."
],
"offsets": [
[
0,
83
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4038
|
split_0_train_4038
|
[
{
"id": "split_0_train_4038_passage",
"type": "progene_text",
"text": [
"Exposure to 1-hexene did not affect neuromuscular coordination in females as determined using the Rotarod , nor sperm counts in male rats ."
],
"offsets": [
[
0,
139
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4039
|
split_0_train_4039
|
[
{
"id": "split_0_train_4039_passage",
"type": "progene_text",
"text": [
"Several statistically significant effects in hematology , clinical chemistry , and urinalysis evaluations were observed , but were either of small magnitude or did not correlate with histopathological findings , and thus did not appear to be of biological significance ."
],
"offsets": [
[
0,
270
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4040
|
split_0_train_4040
|
[
{
"id": "split_0_train_4040_passage",
"type": "progene_text",
"text": [
"In summary , the no - adverse - effect - level for this study was determined to be 1000 ppm , based on decreased weight gain in female rats , and on slight organ weight changes in both sexes at 3000 ppm ."
],
"offsets": [
[
0,
204
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4041
|
split_0_train_4041
|
[
{
"id": "split_0_train_4041_passage",
"type": "progene_text",
"text": [
"The catalytic group-I introns of the psbA gene of chlamydomonas reinhardtii : core structures , ORFs and evolutionary implications ."
],
"offsets": [
[
0,
132
]
]
}
] |
[
{
"id": "split_0_train_6345_entity",
"type": "progene_text",
"text": [
"psbA"
],
"offsets": [
[
37,
41
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4042
|
split_0_train_4042
|
[
{
"id": "split_0_train_4042_passage",
"type": "progene_text",
"text": [
"The sequences and predicted secondary structures of the four catalytic group-I introns in the psbA gene of Chlamydomonas reinhardtii , Cr.psbA-1-Cr.psbA-4 , have been determined ."
],
"offsets": [
[
0,
179
]
]
}
] |
[
{
"id": "split_0_train_6346_entity",
"type": "progene_text",
"text": [
"psbA"
],
"offsets": [
[
94,
98
]
],
"normalized": []
},
{
"id": "split_0_train_6347_entity",
"type": "progene_text",
"text": [
"Cr.psbA-1-Cr.psbA-4"
],
"offsets": [
[
135,
154
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4043
|
split_0_train_4043
|
[
{
"id": "split_0_train_4043_passage",
"type": "progene_text",
"text": [
"Cr.psbA-1 and Cr.psbA-4 are subgroup - IA1 introns and have similar secondary structures , except at the 3' end where Cr.psbA-1 contains a large inverted - repeat domain ."
],
"offsets": [
[
0,
171
]
]
}
] |
[
{
"id": "split_0_train_6348_entity",
"type": "progene_text",
"text": [
"Cr.psbA-1"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "split_0_train_6349_entity",
"type": "progene_text",
"text": [
"Cr.psbA-4"
],
"offsets": [
[
14,
23
]
],
"normalized": []
},
{
"id": "split_0_train_6350_entity",
"type": "progene_text",
"text": [
"Cr.psbA-1"
],
"offsets": [
[
118,
127
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4044
|
split_0_train_4044
|
[
{
"id": "split_0_train_4044_passage",
"type": "progene_text",
"text": [
"Cr.psbA-4 is closely related to intron 1 of the Chlamydomonas moewusii psbA gene , with which it shares the same location , high nucleotide identity in the core , and an identically placed ORF that shows 58 % amino - acid identity ."
],
"offsets": [
[
0,
232
]
]
}
] |
[
{
"id": "split_0_train_6351_entity",
"type": "progene_text",
"text": [
"Cr.psbA-4"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "split_0_train_6352_entity",
"type": "progene_text",
"text": [
"psbA"
],
"offsets": [
[
71,
75
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4045
|
split_0_train_4045
|
[
{
"id": "split_0_train_4045_passage",
"type": "progene_text",
"text": [
"Cr.psbA-2 is a subgroup - IA3 intron , and shows similarities to the Chlamydomonas eugametos rRNA intron , Ce.LSU-1 ."
],
"offsets": [
[
0,
117
]
]
}
] |
[
{
"id": "split_0_train_6353_entity",
"type": "progene_text",
"text": [
"Cr.psbA-2"
],
"offsets": [
[
0,
9
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4046
|
split_0_train_4046
|
[
{
"id": "split_0_train_4046_passage",
"type": "progene_text",
"text": [
"Cr.psbA-3 is a subgroup - IA2 intron , and is remarkably similar to the T4 phage intron , sunY ."
],
"offsets": [
[
0,
96
]
]
}
] |
[
{
"id": "split_0_train_6354_entity",
"type": "progene_text",
"text": [
"Cr.psbA-3"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "split_0_train_6355_entity",
"type": "progene_text",
"text": [
"sunY"
],
"offsets": [
[
90,
94
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4047
|
split_0_train_4047
|
[
{
"id": "split_0_train_4047_passage",
"type": "progene_text",
"text": [
"Interestingly , a degenerate version of Cr.psbA-3 is located in the intergenic region between the chloroplast petA and petD genes ."
],
"offsets": [
[
0,
131
]
]
}
] |
[
{
"id": "split_0_train_6356_entity",
"type": "progene_text",
"text": [
"Cr.psbA-3"
],
"offsets": [
[
40,
49
]
],
"normalized": []
},
{
"id": "split_0_train_6357_entity",
"type": "progene_text",
"text": [
"petA"
],
"offsets": [
[
110,
114
]
],
"normalized": []
},
{
"id": "split_0_train_6358_entity",
"type": "progene_text",
"text": [
"petD"
],
"offsets": [
[
119,
123
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4048
|
split_0_train_4048
|
[
{
"id": "split_0_train_4048_passage",
"type": "progene_text",
"text": [
"All four introns contain ORFs , which potentially code for basic proteins of 11-38 kDa ."
],
"offsets": [
[
0,
88
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4049
|
split_0_train_4049
|
[
{
"id": "split_0_train_4049_passage",
"type": "progene_text",
"text": [
"The ORFs in introns 2 and 3 contain variants of the GIY-YIG motif ; however , the Cr.psbA-2 ORF is free - standing , whereas the Cr.psbA-3 ORF is contiguous and in - frame with the upstream exon ."
],
"offsets": [
[
0,
196
]
]
}
] |
[
{
"id": "split_0_train_6359_entity",
"type": "progene_text",
"text": [
"Cr.psbA-2"
],
"offsets": [
[
82,
91
]
],
"normalized": []
},
{
"id": "split_0_train_6360_entity",
"type": "progene_text",
"text": [
"Cr.psbA-3"
],
"offsets": [
[
129,
138
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4050
|
split_0_train_4050
|
[
{
"id": "split_0_train_4050_passage",
"type": "progene_text",
"text": [
"The Cr.psbA-4 ORF contains an H-N-H motif , and possibly a GIY - YIG motif ."
],
"offsets": [
[
0,
76
]
]
}
] |
[
{
"id": "split_0_train_6361_entity",
"type": "progene_text",
"text": [
"Cr.psbA-4"
],
"offsets": [
[
4,
13
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4051
|
split_0_train_4051
|
[
{
"id": "split_0_train_4051_passage",
"type": "progene_text",
"text": [
"These data indicate that the C. reinhardtiipsbA introns have multiple origins , and illustrate some of the evolutionary DNA dynamics associated with group-I introns in Chlamydomonas ."
],
"offsets": [
[
0,
183
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4052
|
split_0_train_4052
|
[
{
"id": "split_0_train_4052_passage",
"type": "progene_text",
"text": [
"Isolation and characterisation of the retinoic acid receptor - alpha gene in the Japanese pufferfish , F. rubripes ."
],
"offsets": [
[
0,
116
]
]
}
] |
[
{
"id": "split_0_train_6362_entity",
"type": "progene_text",
"text": [
"retinoic acid receptor - alpha"
],
"offsets": [
[
38,
68
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4053
|
split_0_train_4053
|
[
{
"id": "split_0_train_4053_passage",
"type": "progene_text",
"text": [
"Nuclear hormone receptors ( NRs ) are ligand - inducible transcription factors that mediate critical functions in many species ."
],
"offsets": [
[
0,
128
]
]
}
] |
[
{
"id": "split_0_train_6363_entity",
"type": "progene_text",
"text": [
"Nuclear hormone receptors"
],
"offsets": [
[
0,
25
]
],
"normalized": []
},
{
"id": "split_0_train_6364_entity",
"type": "progene_text",
"text": [
"NRs"
],
"offsets": [
[
28,
31
]
],
"normalized": []
},
{
"id": "split_0_train_6365_entity",
"type": "progene_text",
"text": [
"transcription factors"
],
"offsets": [
[
57,
78
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4054
|
split_0_train_4054
|
[
{
"id": "split_0_train_4054_passage",
"type": "progene_text",
"text": [
"The majority of novel NRs have hitherto been cloned from cDNA libraries by virtue of their homology to previously identified receptors ."
],
"offsets": [
[
0,
136
]
]
}
] |
[
{
"id": "split_0_train_6366_entity",
"type": "progene_text",
"text": [
"NRs"
],
"offsets": [
[
22,
25
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4055
|
split_0_train_4055
|
[
{
"id": "split_0_train_4055_passage",
"type": "progene_text",
"text": [
"In this study , we validate a genomic DNA - based approach to isolating NRs by cloning the retinoic acid receptor - alpha ( RARalpha ) gene from the genome of the Japanese pufferfish , Fugu rubripes ."
],
"offsets": [
[
0,
200
]
]
}
] |
[
{
"id": "split_0_train_6367_entity",
"type": "progene_text",
"text": [
"NRs"
],
"offsets": [
[
72,
75
]
],
"normalized": []
},
{
"id": "split_0_train_6368_entity",
"type": "progene_text",
"text": [
"retinoic acid receptor - alpha"
],
"offsets": [
[
91,
121
]
],
"normalized": []
},
{
"id": "split_0_train_6369_entity",
"type": "progene_text",
"text": [
"RARalpha"
],
"offsets": [
[
124,
132
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4056
|
split_0_train_4056
|
[
{
"id": "split_0_train_4056_passage",
"type": "progene_text",
"text": [
"The fRARalpha gene is more compact than its human and murine counterparts and demonstrates a highly conserved genomic organisation and amino acid sequence , generating two isoforms ( fRARalpha1 and fRARalpha2 ) with divergent aminoterminal domains ."
],
"offsets": [
[
0,
249
]
]
}
] |
[
{
"id": "split_0_train_6370_entity",
"type": "progene_text",
"text": [
"fRARalpha"
],
"offsets": [
[
4,
13
]
],
"normalized": []
},
{
"id": "split_0_train_6371_entity",
"type": "progene_text",
"text": [
"fRARalpha1"
],
"offsets": [
[
183,
193
]
],
"normalized": []
},
{
"id": "split_0_train_6372_entity",
"type": "progene_text",
"text": [
"fRARalpha2"
],
"offsets": [
[
198,
208
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4057
|
split_0_train_4057
|
[
{
"id": "split_0_train_4057_passage",
"type": "progene_text",
"text": [
"In addition , a conserved regulatory element containing a retinoic acid response element was identified upstream of the fRARalpha2 - specific exon , implying that retinoid induction of this isoform is evolutionarily conserved and critical to its function in vivo ."
],
"offsets": [
[
0,
264
]
]
}
] |
[
{
"id": "split_0_train_6373_entity",
"type": "progene_text",
"text": [
"fRARalpha2"
],
"offsets": [
[
120,
130
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4058
|
split_0_train_4058
|
[
{
"id": "split_0_train_4058_passage",
"type": "progene_text",
"text": [
"We propose two uses for the Fugu genome in the study of NRs : the isolation of novel NRs that exhibit restricted spatio - temporal expression from genomic DNA and the identification of evolutionarily conserved promoter or intragenic regulatory DNA elements ."
],
"offsets": [
[
0,
258
]
]
}
] |
[
{
"id": "split_0_train_6374_entity",
"type": "progene_text",
"text": [
"NRs"
],
"offsets": [
[
56,
59
]
],
"normalized": []
},
{
"id": "split_0_train_6375_entity",
"type": "progene_text",
"text": [
"NRs"
],
"offsets": [
[
85,
88
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4059
|
split_0_train_4059
|
[
{
"id": "split_0_train_4059_passage",
"type": "progene_text",
"text": [
"Identification by in vivo genomic footprinting of a transcriptional switch containing NF-kappaB and Sp1 that regulates the IkappaBalpha promoter ."
],
"offsets": [
[
0,
146
]
]
}
] |
[
{
"id": "split_0_train_6376_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
86,
95
]
],
"normalized": []
},
{
"id": "split_0_train_6377_entity",
"type": "progene_text",
"text": [
"Sp1"
],
"offsets": [
[
100,
103
]
],
"normalized": []
},
{
"id": "split_0_train_6378_entity",
"type": "progene_text",
"text": [
"IkappaBalpha"
],
"offsets": [
[
123,
135
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4060
|
split_0_train_4060
|
[
{
"id": "split_0_train_4060_passage",
"type": "progene_text",
"text": [
"In unstimulated cells , NF-kappaB transcription factors are retained in the cytoplasm by inhibitory IkappaB proteins ."
],
"offsets": [
[
0,
118
]
]
}
] |
[
{
"id": "split_0_train_6379_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
24,
33
]
],
"normalized": []
},
{
"id": "split_0_train_6380_entity",
"type": "progene_text",
"text": [
"transcription factors"
],
"offsets": [
[
34,
55
]
],
"normalized": []
},
{
"id": "split_0_train_6381_entity",
"type": "progene_text",
"text": [
"IkappaB"
],
"offsets": [
[
100,
107
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4061
|
split_0_train_4061
|
[
{
"id": "split_0_train_4061_passage",
"type": "progene_text",
"text": [
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0,
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194,
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] |
[] |
[] |
[] |
split_0_train_4062
|
split_0_train_4062
|
[
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"type": "progene_text",
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0,
148
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"type": "progene_text",
"text": [
"IkappaBalpha"
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125,
137
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] |
[] |
[] |
[] |
split_0_train_4063
|
split_0_train_4063
|
[
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"id": "split_0_train_4063_passage",
"type": "progene_text",
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"In previous studies , tetracycline - inducible expression of transdominant repressors of IkappaBalpha ( TD - IkappaBalpha ) progressively decreased endogenous IkappaBalpha protein levels ."
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[
0,
188
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}
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[
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"text": [
"IkappaBalpha"
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159,
171
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}
] |
[] |
[] |
[] |
split_0_train_4064
|
split_0_train_4064
|
[
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"id": "split_0_train_4064_passage",
"type": "progene_text",
"text": [
"In the present study , we demonstrate that expression of TD - IkappaBalpha blocked phorbol myristate acetate - phytohemagglutinin or tumor necrosis factor alpha - induced IkappaBalpha gene transcription and abolished NF-kappaB DNA binding activity , due to the continued cytoplasmic sequestration of RelA ( p65 ) by TD - IkappaBalpha ."
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0,
335
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}
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62,
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217,
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{
"id": "split_0_train_6398_entity",
"type": "progene_text",
"text": [
"RelA ( p65 )"
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300,
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"type": "progene_text",
"text": [
"IkappaBalpha"
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"offsets": [
[
321,
333
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}
] |
[] |
[] |
[] |
split_0_train_4065
|
split_0_train_4065
|
[
{
"id": "split_0_train_4065_passage",
"type": "progene_text",
"text": [
"In vivo genomic footprinting revealed stimulus - responsive protein - DNA binding not only to the - 63 to - 53 kappaB1 site but also to the adjacent - 44 to - 36 Sp1 site of the IkappaBalpha promoter ."
],
"offsets": [
[
0,
201
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]
}
] |
[
{
"id": "split_0_train_6400_entity",
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"text": [
"kappaB1"
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111,
118
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{
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"text": [
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162,
165
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{
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"type": "progene_text",
"text": [
"IkappaBalpha"
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"offsets": [
[
178,
190
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4066
|
split_0_train_4066
|
[
{
"id": "split_0_train_4066_passage",
"type": "progene_text",
"text": [
"In vivo protection of both sites was inhibited by tetracycline - inducible TD - IkappaBalpha expression ."
],
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[
0,
105
]
]
}
] |
[
{
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"type": "progene_text",
"text": [
"IkappaBalpha"
],
"offsets": [
[
80,
92
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4067
|
split_0_train_4067
|
[
{
"id": "split_0_train_4067_passage",
"type": "progene_text",
"text": [
"Prolonged NF-kappaB binding and a temporal switch in the composition of NF-kappaB complexes bound to the - 63 to - 53 kappaB1 site of the IkappaBalpha promoter were also observed ; with time after induction , decreased levels of transcriptionally active p50 - p65 and increased p50 - c-Rel heterodimers were detected at the kappaB1 site ."
],
"offsets": [
[
0,
338
]
]
}
] |
[
{
"id": "split_0_train_6404_entity",
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10,
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138,
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254,
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{
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260,
263
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{
"id": "split_0_train_6410_entity",
"type": "progene_text",
"text": [
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278,
281
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{
"id": "split_0_train_6411_entity",
"type": "progene_text",
"text": [
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284,
289
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{
"id": "split_0_train_6412_entity",
"type": "progene_text",
"text": [
"kappaB1"
],
"offsets": [
[
324,
331
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4068
|
split_0_train_4068
|
[
{
"id": "split_0_train_4068_passage",
"type": "progene_text",
"text": [
"Mutation of either the kappaB1 site or the Sp1 site abolished transcription factor binding to the respective sites and the inducibility of the IkappaBalpha promoter in transient transfection studies ."
],
"offsets": [
[
0,
200
]
]
}
] |
[
{
"id": "split_0_train_6413_entity",
"type": "progene_text",
"text": [
"kappaB1"
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[
23,
30
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},
{
"id": "split_0_train_6414_entity",
"type": "progene_text",
"text": [
"Sp1"
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"offsets": [
[
43,
46
]
],
"normalized": []
},
{
"id": "split_0_train_6415_entity",
"type": "progene_text",
"text": [
"transcription factor"
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[
62,
82
]
],
"normalized": []
},
{
"id": "split_0_train_6416_entity",
"type": "progene_text",
"text": [
"IkappaBalpha"
],
"offsets": [
[
143,
155
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4069
|
split_0_train_4069
|
[
{
"id": "split_0_train_4069_passage",
"type": "progene_text",
"text": [
"These observations provide the first in vivo characterization of a promoter proximal transcriptional switch involving NF-kappaB and Sp1 that is essential for autoregulation of the IkappaBalpha promoter ."
],
"offsets": [
[
0,
203
]
]
}
] |
[
{
"id": "split_0_train_6417_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
118,
127
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],
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},
{
"id": "split_0_train_6418_entity",
"type": "progene_text",
"text": [
"Sp1"
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[
132,
135
]
],
"normalized": []
},
{
"id": "split_0_train_6419_entity",
"type": "progene_text",
"text": [
"IkappaBalpha"
],
"offsets": [
[
180,
192
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4070
|
split_0_train_4070
|
[
{
"id": "split_0_train_4070_passage",
"type": "progene_text",
"text": [
"Cloning , expression profile , and genomic organization of the mouse STAP / A170 gene ."
],
"offsets": [
[
0,
87
]
]
}
] |
[
{
"id": "split_0_train_6420_entity",
"type": "progene_text",
"text": [
"STAP"
],
"offsets": [
[
69,
73
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],
"normalized": []
},
{
"id": "split_0_train_6421_entity",
"type": "progene_text",
"text": [
"A170"
],
"offsets": [
[
76,
80
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4071
|
split_0_train_4071
|
[
{
"id": "split_0_train_4071_passage",
"type": "progene_text",
"text": [
"The preferential screening of cDNA libraries derived from the mouse osteoblastic cell line MC3T3-E1 has yielded a cDNA clone encoding a 442 - amino - acid protein designated STAP ( signal transduction and adaptor protein ) , which contains several motifs shared among transcription factors and adaptors such as a Zn - finger like motif , a proline - rich domain , and a PEST sequence ."
],
"offsets": [
[
0,
385
]
]
}
] |
[
{
"id": "split_0_train_6422_entity",
"type": "progene_text",
"text": [
"STAP"
],
"offsets": [
[
174,
178
]
],
"normalized": []
},
{
"id": "split_0_train_6423_entity",
"type": "progene_text",
"text": [
"signal transduction and adaptor protein"
],
"offsets": [
[
181,
220
]
],
"normalized": []
},
{
"id": "split_0_train_6424_entity",
"type": "progene_text",
"text": [
"transcription factors"
],
"offsets": [
[
268,
289
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4072
|
split_0_train_4072
|
[
{
"id": "split_0_train_4072_passage",
"type": "progene_text",
"text": [
"The amino acid sequence homology search also reveals that STAP is identical to a mouse oxidative stress protein , A170 , and has 90 % homology with a human p62 protein that binds to the tyrosine kinase p56(lck) SH2 domain ."
],
"offsets": [
[
0,
223
]
]
}
] |
[
{
"id": "split_0_train_6425_entity",
"type": "progene_text",
"text": [
"STAP"
],
"offsets": [
[
58,
62
]
],
"normalized": []
},
{
"id": "split_0_train_6426_entity",
"type": "progene_text",
"text": [
"A170"
],
"offsets": [
[
114,
118
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4073
|
split_0_train_4073
|
[
{
"id": "split_0_train_4073_passage",
"type": "progene_text",
"text": [
"Northern blot analysis indicated a broad expression profile of STAP mRNA in various tissues and cell lines ."
],
"offsets": [
[
0,
108
]
]
}
] |
[
{
"id": "split_0_train_6427_entity",
"type": "progene_text",
"text": [
"STAP"
],
"offsets": [
[
63,
67
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4074
|
split_0_train_4074
|
[
{
"id": "split_0_train_4074_passage",
"type": "progene_text",
"text": [
"In MC3T3-E1 cells , STAP mRNA was induced by treatment with TGF-beta , but not with BMP-2 or GDF-5 ."
],
"offsets": [
[
0,
100
]
]
}
] |
[
{
"id": "split_0_train_6428_entity",
"type": "progene_text",
"text": [
"STAP"
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"offsets": [
[
20,
24
]
],
"normalized": []
},
{
"id": "split_0_train_6429_entity",
"type": "progene_text",
"text": [
"TGF-beta"
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"offsets": [
[
60,
68
]
],
"normalized": []
},
{
"id": "split_0_train_6430_entity",
"type": "progene_text",
"text": [
"BMP-2"
],
"offsets": [
[
84,
89
]
],
"normalized": []
},
{
"id": "split_0_train_6431_entity",
"type": "progene_text",
"text": [
"GDF-5"
],
"offsets": [
[
93,
98
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4075
|
split_0_train_4075
|
[
{
"id": "split_0_train_4075_passage",
"type": "progene_text",
"text": [
"Analysis of the mouse STAP gene isolated from the genomic library revealed that the STAP gene spans a region of over 11 kb and comprises eight exons ."
],
"offsets": [
[
0,
150
]
]
}
] |
[
{
"id": "split_0_train_6432_entity",
"type": "progene_text",
"text": [
"STAP"
],
"offsets": [
[
22,
26
]
],
"normalized": []
},
{
"id": "split_0_train_6433_entity",
"type": "progene_text",
"text": [
"STAP"
],
"offsets": [
[
84,
88
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4076
|
split_0_train_4076
|
[
{
"id": "split_0_train_4076_passage",
"type": "progene_text",
"text": [
"The transcription start site was identified by primer extension analysis to be located 35 bp upstream from the translation initiation site ."
],
"offsets": [
[
0,
140
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4077
|
split_0_train_4077
|
[
{
"id": "split_0_train_4077_passage",
"type": "progene_text",
"text": [
"Sequencing analysis of the 5' flanking region of the STAP gene revealed multiple consensus motifs / sequences for several DNA binding transcription factors ."
],
"offsets": [
[
0,
157
]
]
}
] |
[
{
"id": "split_0_train_6434_entity",
"type": "progene_text",
"text": [
"STAP"
],
"offsets": [
[
53,
57
]
],
"normalized": []
},
{
"id": "split_0_train_6435_entity",
"type": "progene_text",
"text": [
"transcription factors"
],
"offsets": [
[
134,
155
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4078
|
split_0_train_4078
|
[
{
"id": "split_0_train_4078_passage",
"type": "progene_text",
"text": [
"The STAP gene had a TATA box , but no CCAAT box ."
],
"offsets": [
[
0,
49
]
]
}
] |
[
{
"id": "split_0_train_6436_entity",
"type": "progene_text",
"text": [
"STAP"
],
"offsets": [
[
4,
8
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4079
|
split_0_train_4079
|
[
{
"id": "split_0_train_4079_passage",
"type": "progene_text",
"text": [
"Potential Sp1 , AP-1 , NF-E2 , MyoD , and NF-kappaB binding sites were found in the 5' flanking region ( 1.4 kb ) of the STAP gene ."
],
"offsets": [
[
0,
132
]
]
}
] |
[
{
"id": "split_0_train_6437_entity",
"type": "progene_text",
"text": [
"Sp1"
],
"offsets": [
[
10,
13
]
],
"normalized": []
},
{
"id": "split_0_train_6438_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
16,
20
]
],
"normalized": []
},
{
"id": "split_0_train_6439_entity",
"type": "progene_text",
"text": [
"NF-E2"
],
"offsets": [
[
23,
28
]
],
"normalized": []
},
{
"id": "split_0_train_6440_entity",
"type": "progene_text",
"text": [
"MyoD"
],
"offsets": [
[
31,
35
]
],
"normalized": []
},
{
"id": "split_0_train_6441_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
42,
51
]
],
"normalized": []
},
{
"id": "split_0_train_6442_entity",
"type": "progene_text",
"text": [
"STAP"
],
"offsets": [
[
121,
125
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4080
|
split_0_train_4080
|
[
{
"id": "split_0_train_4080_passage",
"type": "progene_text",
"text": [
"The Escherichia coli NadR regulator is endowed with nicotinamide mononucleotide adenylyltransferase activity ."
],
"offsets": [
[
0,
110
]
]
}
] |
[
{
"id": "split_0_train_6443_entity",
"type": "progene_text",
"text": [
"NadR"
],
"offsets": [
[
21,
25
]
],
"normalized": []
},
{
"id": "split_0_train_6444_entity",
"type": "progene_text",
"text": [
"nicotinamide mononucleotide adenylyltransferase"
],
"offsets": [
[
52,
99
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4081
|
split_0_train_4081
|
[
{
"id": "split_0_train_4081_passage",
"type": "progene_text",
"text": [
"The first identification and characterization of a catalytic activity associated with NadR protein is reported ."
],
"offsets": [
[
0,
112
]
]
}
] |
[
{
"id": "split_0_train_6445_entity",
"type": "progene_text",
"text": [
"NadR"
],
"offsets": [
[
86,
90
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4082
|
split_0_train_4082
|
[
{
"id": "split_0_train_4082_passage",
"type": "progene_text",
"text": [
"A computer - aided search for sequence similarity revealed the presence in NadR of a 29 - residue region highly conserved among known nicotinamide mononucleotide adenylyltransferases ."
],
"offsets": [
[
0,
184
]
]
}
] |
[
{
"id": "split_0_train_6446_entity",
"type": "progene_text",
"text": [
"NadR"
],
"offsets": [
[
75,
79
]
],
"normalized": []
},
{
"id": "split_0_train_6447_entity",
"type": "progene_text",
"text": [
"nicotinamide mononucleotide adenylyltransferases"
],
"offsets": [
[
134,
182
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4083
|
split_0_train_4083
|
[
{
"id": "split_0_train_4083_passage",
"type": "progene_text",
"text": [
"The Escherichia coli nadR gene was cloned into a T7 - based vector and overexpressed ."
],
"offsets": [
[
0,
86
]
]
}
] |
[
{
"id": "split_0_train_6448_entity",
"type": "progene_text",
"text": [
"nadR"
],
"offsets": [
[
21,
25
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_4084
|
split_0_train_4084
|
[
{
"id": "split_0_train_4084_passage",
"type": "progene_text",
"text": [
"In addition to functionally specific DNA binding properties , the homogeneous recombinant protein catalyzes NAD synthesis from nicotinamide mononucleotide and ATP ."
],
"offsets": [
[
0,
164
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4085
|
split_0_train_4085
|
[
{
"id": "split_0_train_4085_passage",
"type": "progene_text",
"text": [
"Chemical uptake into human stratum corneum in vivo from volatile and non - volatile solvents ."
],
"offsets": [
[
0,
94
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4086
|
split_0_train_4086
|
[
{
"id": "split_0_train_4086_passage",
"type": "progene_text",
"text": [
"PURPOSE :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4087
|
split_0_train_4087
|
[
{
"id": "split_0_train_4087_passage",
"type": "progene_text",
"text": [
"Simple , safe and quick in vivo methods for estimating chemical uptake into the stratum corneum ( SC ) from volatile and non - volatile solvents are invaluable to health risk assessors ."
],
"offsets": [
[
0,
186
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4088
|
split_0_train_4088
|
[
{
"id": "split_0_train_4088_passage",
"type": "progene_text",
"text": [
"This study compares the human in vivo SC uptake of a model compound ( 4-cyanophenol ) from water and acetone using quantitative attenuated total reflectance - Fourier transform infrared ( ATR-FTIR ) spectroscopy ."
],
"offsets": [
[
0,
213
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4089
|
split_0_train_4089
|
[
{
"id": "split_0_train_4089_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4090
|
split_0_train_4090
|
[
{
"id": "split_0_train_4090_passage",
"type": "progene_text",
"text": [
"Small areas on the ventral forearms of human volunteers were treated with 4-cyanophenol ( CP ) dissolved either in water or acetone ."
],
"offsets": [
[
0,
133
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4091
|
split_0_train_4091
|
[
{
"id": "split_0_train_4091_passage",
"type": "progene_text",
"text": [
"After the skin was cleansed of remaining surface CP , SC samples were taken by a standard tape - stripping method ."
],
"offsets": [
[
0,
115
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4092
|
split_0_train_4092
|
[
{
"id": "split_0_train_4092_passage",
"type": "progene_text",
"text": [
"CP concentration profiles across the SC were quantitated by direct measurement of the permeant on the individual tape - strips using ATR-FTIR ."
],
"offsets": [
[
0,
143
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4093
|
split_0_train_4093
|
[
{
"id": "split_0_train_4093_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4094
|
split_0_train_4094
|
[
{
"id": "split_0_train_4094_passage",
"type": "progene_text",
"text": [
"Increasing the duration of exposure to CP aqueous solutions resulted in increasing CP uptake into the SC ; the kinetics of uptake correlated well with predictive diffusion equations ."
],
"offsets": [
[
0,
183
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4095
|
split_0_train_4095
|
[
{
"id": "split_0_train_4095_passage",
"type": "progene_text",
"text": [
"Increasing the ' dose ' of CP in acetone also resulted in increasing uptake into the SC , but uptake eventually plateaued at a maximum level ."
],
"offsets": [
[
0,
142
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4096
|
split_0_train_4096
|
[
{
"id": "split_0_train_4096_passage",
"type": "progene_text",
"text": [
"The amount of CP taken up into the SC from acetone was 2 to 8 - fold greater than that from water following similar short - time exposures ."
],
"offsets": [
[
0,
140
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4097
|
split_0_train_4097
|
[
{
"id": "split_0_train_4097_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4098
|
split_0_train_4098
|
[
{
"id": "split_0_train_4098_passage",
"type": "progene_text",
"text": [
"These safe , simple experimental methods provide practical and predictive assessments of chemical uptake into human SC in vivo ."
],
"offsets": [
[
0,
128
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_4099
|
split_0_train_4099
|
[
{
"id": "split_0_train_4099_passage",
"type": "progene_text",
"text": [
"Genomic organization of the S locus : Identification and characterization of genes in SLG / SRK region of S(9) haplotype of Brassica campestris ( syn. rapa ) ."
],
"offsets": [
[
0,
159
]
]
}
] |
[
{
"id": "split_0_train_6449_entity",
"type": "progene_text",
"text": [
"SLG"
],
"offsets": [
[
86,
89
]
],
"normalized": []
},
{
"id": "split_0_train_6450_entity",
"type": "progene_text",
"text": [
"SRK"
],
"offsets": [
[
92,
95
]
],
"normalized": []
}
] |
[] |
[] |
[] |
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