id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_3800 | split_0_train_3800 | [
{
"id": "split_0_train_3800_passage",
"type": "progene_text",
"text": [
"In the absence of L-arginine or at lower protein concentrations , the hexamers are clearly in rapid equilibrium with smaller subunits , whose dominant species appear to be based on trimers , as expected from the crystal structure of the ArgR C - terminal fragment , with the exception of the ArgR - C chimera , which apparently dissociates into dimers , suggesting that in the intact protein the DNA - binding domains may have a significant dimeric interaction ."
],
"offsets": [
[
0,
462
]
]
}
]
| [
{
"id": "split_0_train_6091_entity",
"type": "progene_text",
"text": [
"ArgR"
],
"offsets": [
[
237,
241
]
],
"normalized": []
},
{
"id": "split_0_train_6092_entity",
"type": "progene_text",
"text": [
"ArgR"
],
"offsets": [
[
292,
296
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3801 | split_0_train_3801 | [
{
"id": "split_0_train_3801_passage",
"type": "progene_text",
"text": [
"The hexamer - trimer Kdis in the micromolar range , suggesting that trimers are the principal species at in vivo concentrations.DNA binding by all four proteins has been probed by gel retardation and DNase I footprinting analysis using all three types of naturally occurring operators : biosynthetic sites encompassing two 18 bp ARG boxes separated by 2 bp ; biosynthetic sites containing two such boxes and a third 18 bp ARG box at a distance of 100 bp downstream , i.e. within the structural gene ; and finally a catabolic operator which contains a single ARG box site ."
],
"offsets": [
[
0,
572
]
]
}
]
| [
{
"id": "split_0_train_6093_entity",
"type": "progene_text",
"text": [
"DNase I"
],
"offsets": [
[
200,
207
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3802 | split_0_train_3802 | [
{
"id": "split_0_train_3802_passage",
"type": "progene_text",
"text": [
"The data show that all four proteins bind to the operators at the expected regions in an L-arginine - dependent fashion ."
],
"offsets": [
[
0,
121
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3803 | split_0_train_3803 | [
{
"id": "split_0_train_3803_passage",
"type": "progene_text",
"text": [
"From the apparent affinities of the chimeras for each target site , there is no obvious sequence - specificity associated with the N - terminal domains ; rather the data can be interpreted in terms of differential allosteric activation , including DNA binding in the absence of L-arginine.Remarkably , the proteins show apparent \" anti - competition \" in the presence of excess , specific DNA fragments in gel retardation ."
],
"offsets": [
[
0,
423
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3804 | split_0_train_3804 | [
{
"id": "split_0_train_3804_passage",
"type": "progene_text",
"text": [
"This appears to be due to assembly of an activated form of the protein , probably hexamers , on the operator DNA ."
],
"offsets": [
[
0,
114
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3805 | split_0_train_3805 | [
{
"id": "split_0_train_3805_passage",
"type": "progene_text",
"text": [
"The data are discussed in terms of the current models for the mode of action of both native proteins ."
],
"offsets": [
[
0,
102
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3806 | split_0_train_3806 | [
{
"id": "split_0_train_3806_passage",
"type": "progene_text",
"text": [
"Dominant negative murine serum response factor : alternative splicing within the activation domain inhibits transactivation of serum response factor binding targets ."
],
"offsets": [
[
0,
166
]
]
}
]
| [
{
"id": "split_0_train_6094_entity",
"type": "progene_text",
"text": [
"serum response factor"
],
"offsets": [
[
25,
46
]
],
"normalized": []
},
{
"id": "split_0_train_6095_entity",
"type": "progene_text",
"text": [
"serum response factor"
],
"offsets": [
[
127,
148
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3807 | split_0_train_3807 | [
{
"id": "split_0_train_3807_passage",
"type": "progene_text",
"text": [
"Primary transcripts encoding the MADS box superfamily of proteins , such as MEF2 in animals and ZEMa in plants , are alternatively spliced , producing several isoformic species ."
],
"offsets": [
[
0,
178
]
]
}
]
| [
{
"id": "split_0_train_6096_entity",
"type": "progene_text",
"text": [
"MADS box superfamily"
],
"offsets": [
[
33,
53
]
],
"normalized": []
},
{
"id": "split_0_train_6097_entity",
"type": "progene_text",
"text": [
"MEF2"
],
"offsets": [
[
76,
80
]
],
"normalized": []
},
{
"id": "split_0_train_6098_entity",
"type": "progene_text",
"text": [
"ZEMa"
],
"offsets": [
[
96,
100
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3808 | split_0_train_3808 | [
{
"id": "split_0_train_3808_passage",
"type": "progene_text",
"text": [
"We show here that murine serum response factor ( SRF ) primary RNA transcripts are alternatively spliced at the fifth exon , deleting approximately one - third of the C - terminal activation domain ."
],
"offsets": [
[
0,
199
]
]
}
]
| [
{
"id": "split_0_train_6099_entity",
"type": "progene_text",
"text": [
"serum response factor"
],
"offsets": [
[
25,
46
]
],
"normalized": []
},
{
"id": "split_0_train_6100_entity",
"type": "progene_text",
"text": [
"SRF"
],
"offsets": [
[
49,
52
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3809 | split_0_train_3809 | [
{
"id": "split_0_train_3809_passage",
"type": "progene_text",
"text": [
"Among the different muscle types examined , visceral smooth muscles have a very low ratio of SRFDelta5 to SRF ."
],
"offsets": [
[
0,
111
]
]
}
]
| [
{
"id": "split_0_train_6101_entity",
"type": "progene_text",
"text": [
"SRFDelta5"
],
"offsets": [
[
93,
102
]
],
"normalized": []
},
{
"id": "split_0_train_6102_entity",
"type": "progene_text",
"text": [
"SRF"
],
"offsets": [
[
106,
109
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3810 | split_0_train_3810 | [
{
"id": "split_0_train_3810_passage",
"type": "progene_text",
"text": [
"Increased levels of SRFDelta5 correlates well with reduced smooth muscle contractile gene activity within the elastic aortic arch , suggesting important biological roles for differential expression of SRFDelta5 variant relative to wild - type SRF ."
],
"offsets": [
[
0,
248
]
]
}
]
| [
{
"id": "split_0_train_6103_entity",
"type": "progene_text",
"text": [
"SRFDelta5"
],
"offsets": [
[
20,
29
]
],
"normalized": []
},
{
"id": "split_0_train_6104_entity",
"type": "progene_text",
"text": [
"SRFDelta5"
],
"offsets": [
[
201,
210
]
],
"normalized": []
},
{
"id": "split_0_train_6105_entity",
"type": "progene_text",
"text": [
"SRF"
],
"offsets": [
[
243,
246
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3811 | split_0_train_3811 | [
{
"id": "split_0_train_3811_passage",
"type": "progene_text",
"text": [
"SRFDelta5 forms DNA binding - competent homodimers and heterodimers ."
],
"offsets": [
[
0,
69
]
]
}
]
| [
{
"id": "split_0_train_6106_entity",
"type": "progene_text",
"text": [
"SRFDelta5"
],
"offsets": [
[
0,
9
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3812 | split_0_train_3812 | [
{
"id": "split_0_train_3812_passage",
"type": "progene_text",
"text": [
"SRFDelta5 acts as a naturally occurring dominant negative regulatory mutant that blocks SRF - dependent skeletal alpha-actin , cardiac alpha-actin , smooth alpha-actin , SM22alpha , and SRF promoter - luciferase reporter activities ."
],
"offsets": [
[
0,
233
]
]
}
]
| [
{
"id": "split_0_train_6107_entity",
"type": "progene_text",
"text": [
"SRFDelta5"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "split_0_train_6108_entity",
"type": "progene_text",
"text": [
"SRF"
],
"offsets": [
[
88,
91
]
],
"normalized": []
},
{
"id": "split_0_train_6109_entity",
"type": "progene_text",
"text": [
"alpha-actin"
],
"offsets": [
[
113,
124
]
],
"normalized": []
},
{
"id": "split_0_train_6110_entity",
"type": "progene_text",
"text": [
"alpha-actin"
],
"offsets": [
[
135,
146
]
],
"normalized": []
},
{
"id": "split_0_train_6111_entity",
"type": "progene_text",
"text": [
"alpha-actin"
],
"offsets": [
[
156,
167
]
],
"normalized": []
},
{
"id": "split_0_train_6112_entity",
"type": "progene_text",
"text": [
"SM22alpha"
],
"offsets": [
[
170,
179
]
],
"normalized": []
},
{
"id": "split_0_train_6113_entity",
"type": "progene_text",
"text": [
"SRF"
],
"offsets": [
[
186,
189
]
],
"normalized": []
},
{
"id": "split_0_train_6114_entity",
"type": "progene_text",
"text": [
"luciferase"
],
"offsets": [
[
201,
211
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3813 | split_0_train_3813 | [
{
"id": "split_0_train_3813_passage",
"type": "progene_text",
"text": [
"Expression of SRFDelta5 interferes with differentiation of myogenic C2C12 cells and the appearance of skeletal alpha-actin and myogenin mRNAs ."
],
"offsets": [
[
0,
143
]
]
}
]
| [
{
"id": "split_0_train_6115_entity",
"type": "progene_text",
"text": [
"SRFDelta5"
],
"offsets": [
[
14,
23
]
],
"normalized": []
},
{
"id": "split_0_train_6116_entity",
"type": "progene_text",
"text": [
"skeletal alpha-actin"
],
"offsets": [
[
102,
122
]
],
"normalized": []
},
{
"id": "split_0_train_6117_entity",
"type": "progene_text",
"text": [
"myogenin"
],
"offsets": [
[
127,
135
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3814 | split_0_train_3814 | [
{
"id": "split_0_train_3814_passage",
"type": "progene_text",
"text": [
"SRFDelta5 repressed the serum - induced activity of the c-fos serum response element ."
],
"offsets": [
[
0,
86
]
]
}
]
| [
{
"id": "split_0_train_6118_entity",
"type": "progene_text",
"text": [
"SRFDelta5"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "split_0_train_6119_entity",
"type": "progene_text",
"text": [
"c-fos"
],
"offsets": [
[
56,
61
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3815 | split_0_train_3815 | [
{
"id": "split_0_train_3815_passage",
"type": "progene_text",
"text": [
"SRFDelta5 fused to the yeast Gal4 DNA binding domain displayed low transcriptional activity , which was complemented by overexpression of the coactivator ATF6 ."
],
"offsets": [
[
0,
160
]
]
}
]
| [
{
"id": "split_0_train_6120_entity",
"type": "progene_text",
"text": [
"SRFDelta5"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "split_0_train_6121_entity",
"type": "progene_text",
"text": [
"Gal4"
],
"offsets": [
[
29,
33
]
],
"normalized": []
},
{
"id": "split_0_train_6122_entity",
"type": "progene_text",
"text": [
"ATF6"
],
"offsets": [
[
154,
158
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3816 | split_0_train_3816 | [
{
"id": "split_0_train_3816_passage",
"type": "progene_text",
"text": [
"These results indicate that the absence of exon 5 might be bypassed through recruitment of transcription factors that interact with extra - exon 5 regions in the transcriptional activating domain ."
],
"offsets": [
[
0,
197
]
]
}
]
| [
{
"id": "split_0_train_6123_entity",
"type": "progene_text",
"text": [
"transcription factors"
],
"offsets": [
[
91,
112
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3817 | split_0_train_3817 | [
{
"id": "split_0_train_3817_passage",
"type": "progene_text",
"text": [
"The novel alternatively spliced isoform of SRF , SRFDelta5 , may play an important regulatory role in modulating SRF - dependent gene expression ."
],
"offsets": [
[
0,
146
]
]
}
]
| [
{
"id": "split_0_train_6124_entity",
"type": "progene_text",
"text": [
"SRF"
],
"offsets": [
[
43,
46
]
],
"normalized": []
},
{
"id": "split_0_train_6125_entity",
"type": "progene_text",
"text": [
"SRFDelta5"
],
"offsets": [
[
49,
58
]
],
"normalized": []
},
{
"id": "split_0_train_6126_entity",
"type": "progene_text",
"text": [
"SRF"
],
"offsets": [
[
113,
116
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3818 | split_0_train_3818 | [
{
"id": "split_0_train_3818_passage",
"type": "progene_text",
"text": [
"A potential mechanism for selective control of cap - independent translation by a viral RNA sequence in cis and in trans ."
],
"offsets": [
[
0,
122
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3819 | split_0_train_3819 | [
{
"id": "split_0_train_3819_passage",
"type": "progene_text",
"text": [
"Highly efficient cap - independent translation initiation at the 5'-proximal AUG is facilitated by the 3' translation enhancer sequence ( 3'TE ) located near the 3' end of barley yellow dwarf virus ( BYDV ) genomic RNA ."
],
"offsets": [
[
0,
220
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3820 | split_0_train_3820 | [
{
"id": "split_0_train_3820_passage",
"type": "progene_text",
"text": [
"The role of the 3'TE in regulating viral translation was examined ."
],
"offsets": [
[
0,
67
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3821 | split_0_train_3821 | [
{
"id": "split_0_train_3821_passage",
"type": "progene_text",
"text": [
"The 3' TE is required for translation and thus replication of the genomic RNA that lacks a 5' cap ( Allen et al. , 1999 , Virology253 : 139 - 144 ) ."
],
"offsets": [
[
0,
149
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3822 | split_0_train_3822 | [
{
"id": "split_0_train_3822_passage",
"type": "progene_text",
"text": [
"Here we show that the 3' TE also mediates translation of uncapped viral subgenomic mRNAs ( sgRNA1 and sgRNA2 ) ."
],
"offsets": [
[
0,
112
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3823 | split_0_train_3823 | [
{
"id": "split_0_train_3823_passage",
"type": "progene_text",
"text": [
"A 109 - nt viral sequence is sufficient for 3'TE activity in vitro , but additional viral sequence is necessary for cap - independent translation in vivo ."
],
"offsets": [
[
0,
155
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3824 | split_0_train_3824 | [
{
"id": "split_0_train_3824_passage",
"type": "progene_text",
"text": [
"The 5' extremity of the sequence required in the 3' untranslated region ( UTR ) for cap - independent translation in vivo coincides with the 5' end of sgRNA2 ."
],
"offsets": [
[
0,
159
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3825 | split_0_train_3825 | [
{
"id": "split_0_train_3825_passage",
"type": "progene_text",
"text": [
"Thus , sgRNA2 has the 3'TE in its 5' UTR ."
],
"offsets": [
[
0,
42
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3826 | split_0_train_3826 | [
{
"id": "split_0_train_3826_passage",
"type": "progene_text",
"text": [
"Competition studies using physiological ratios of viral RNAs showed that , in trans , the 109 - nt 3'TE alone , or in the context of 869 - nt sgRNA2 , inhibited translation of genomic RNA much more than it inhibited translation of sgRNA1 ."
],
"offsets": [
[
0,
239
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3827 | split_0_train_3827 | [
{
"id": "split_0_train_3827_passage",
"type": "progene_text",
"text": [
"The divergent 5' UTRs of genomic RNA and sgRNA1 contribute to this differential susceptibility to inhibition ."
],
"offsets": [
[
0,
110
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3828 | split_0_train_3828 | [
{
"id": "split_0_train_3828_passage",
"type": "progene_text",
"text": [
"We propose that sgRNA2 serves as a novel regulatory RNA to carry out the switch from early to late gene expression ."
],
"offsets": [
[
0,
116
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3829 | split_0_train_3829 | [
{
"id": "split_0_train_3829_passage",
"type": "progene_text",
"text": [
"Thus , this new mechanism for temporal control of translation control involves a sequence that stimulates translation in cis and acts in trans to selectively inhibit translation of viral mRNA ."
],
"offsets": [
[
0,
193
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3830 | split_0_train_3830 | [
{
"id": "split_0_train_3830_passage",
"type": "progene_text",
"text": [
"Cost - effectiveness analysis of tropisetron vs. chlorpromazine - dexamethasone in the control of acute emesis induced by highly emetogenic chemotherapy in children ."
],
"offsets": [
[
0,
166
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3831 | split_0_train_3831 | [
{
"id": "split_0_train_3831_passage",
"type": "progene_text",
"text": [
"OBJECTIVE :"
],
"offsets": [
[
0,
11
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3832 | split_0_train_3832 | [
{
"id": "split_0_train_3832_passage",
"type": "progene_text",
"text": [
"To perform a cost - effectiveness analysis ( CEA ) between a standard antiemetic regimen - chlorpromazine + dexamethasone ( CPM-DEX ) - and a 5-HT3 receptor antagonist - tropisetron ( TROP ) --in the control of acute emesis induced by highly emetogenic chemotherapy in children , considering two analytic perspectives : hospital and patients ."
],
"offsets": [
[
0,
343
]
]
}
]
| [
{
"id": "split_0_train_6127_entity",
"type": "progene_text",
"text": [
"5-HT3 receptor"
],
"offsets": [
[
142,
156
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3833 | split_0_train_3833 | [
{
"id": "split_0_train_3833_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3834 | split_0_train_3834 | [
{
"id": "split_0_train_3834_passage",
"type": "progene_text",
"text": [
"The CEA was performed by constructing a decision tree , for both analytic perspectives , of the possible outcomes of treatment with TROP ( single 0.2 mg / kg i.v. ) or CPM ( 5-15 mg i.v. infusion for 3 doses ) plus DEX ( 2 mg / m2 i.v. bolus i.v. x2 ) ."
],
"offsets": [
[
0,
253
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3835 | split_0_train_3835 | [
{
"id": "split_0_train_3835_passage",
"type": "progene_text",
"text": [
"The patients were stratified by age in two groups ( 2 - 12 and 13-17 ) ."
],
"offsets": [
[
0,
72
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3836 | split_0_train_3836 | [
{
"id": "split_0_train_3836_passage",
"type": "progene_text",
"text": [
"To estimate the probability of each endpoint at the decision tree we have taken as a base a trial developed in the Department of Pediatrics ."
],
"offsets": [
[
0,
141
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3837 | split_0_train_3837 | [
{
"id": "split_0_train_3837_passage",
"type": "progene_text",
"text": [
"Direct medical cost of primary therapy , failure , complications and side effects were included in the cost calculations ."
],
"offsets": [
[
0,
122
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3838 | split_0_train_3838 | [
{
"id": "split_0_train_3838_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3839 | split_0_train_3839 | [
{
"id": "split_0_train_3839_passage",
"type": "progene_text",
"text": [
"From patients ' analytic perspective , TROP was more cost - effective than CPM - DEX for both groups of patients ."
],
"offsets": [
[
0,
114
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3840 | split_0_train_3840 | [
{
"id": "split_0_train_3840_passage",
"type": "progene_text",
"text": [
"Discrepancy between both analytic perspectives in 13 - 17 year - old patient 's group was resolved in favour of the option chosen from the patients ' analytic perspective ( TROP ) ."
],
"offsets": [
[
0,
181
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3841 | split_0_train_3841 | [
{
"id": "split_0_train_3841_passage",
"type": "progene_text",
"text": [
"Sensitivity analysis showed the reliability of the results ."
],
"offsets": [
[
0,
60
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3842 | split_0_train_3842 | [
{
"id": "split_0_train_3842_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3843 | split_0_train_3843 | [
{
"id": "split_0_train_3843_passage",
"type": "progene_text",
"text": [
"1 ."
],
"offsets": [
[
0,
3
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3844 | split_0_train_3844 | [
{
"id": "split_0_train_3844_passage",
"type": "progene_text",
"text": [
"TROP was more cost - effective than CPM-DEX ."
],
"offsets": [
[
0,
45
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3845 | split_0_train_3845 | [
{
"id": "split_0_train_3845_passage",
"type": "progene_text",
"text": [
"2 ."
],
"offsets": [
[
0,
3
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3846 | split_0_train_3846 | [
{
"id": "split_0_train_3846_passage",
"type": "progene_text",
"text": [
"Taking into account the patients ' analytic perspective is essential when we compare antiemetics pharmacoeconomically ."
],
"offsets": [
[
0,
119
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3847 | split_0_train_3847 | [
{
"id": "split_0_train_3847_passage",
"type": "progene_text",
"text": [
"3 ."
],
"offsets": [
[
0,
3
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3848 | split_0_train_3848 | [
{
"id": "split_0_train_3848_passage",
"type": "progene_text",
"text": [
"It seems necessary to increase the effectiveness of TROP in pediatric patients receiving highly emetogenic chemotherapy with strategies such as the addition of a steroid ."
],
"offsets": [
[
0,
171
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3849 | split_0_train_3849 | [
{
"id": "split_0_train_3849_passage",
"type": "progene_text",
"text": [
"sigmaK can negatively regulate sigE expression by two different mechanisms during sporulation of Bacillus subtilis ."
],
"offsets": [
[
0,
116
]
]
}
]
| [
{
"id": "split_0_train_6128_entity",
"type": "progene_text",
"text": [
"sigmaK"
],
"offsets": [
[
0,
6
]
],
"normalized": []
},
{
"id": "split_0_train_6129_entity",
"type": "progene_text",
"text": [
"sigE"
],
"offsets": [
[
31,
35
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3850 | split_0_train_3850 | [
{
"id": "split_0_train_3850_passage",
"type": "progene_text",
"text": [
"Temporal and spatial gene regulation during Bacillus subtilis sporulation involves the activation and inactivation of multiple sigma subunits of RNA polymerase in a cascade ."
],
"offsets": [
[
0,
174
]
]
}
]
| [
{
"id": "split_0_train_6130_entity",
"type": "progene_text",
"text": [
"sigma subunits of RNA polymerase"
],
"offsets": [
[
127,
159
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3851 | split_0_train_3851 | [
{
"id": "split_0_train_3851_passage",
"type": "progene_text",
"text": [
"In the mother cell compartment of sporulating cells , expression of the sigE gene , encoding the earlier - acting sigma factor , sigmaE , is negatively regulated by the later - acting sigma factor , sigmaK ."
],
"offsets": [
[
0,
207
]
]
}
]
| [
{
"id": "split_0_train_6131_entity",
"type": "progene_text",
"text": [
"sigE"
],
"offsets": [
[
72,
76
]
],
"normalized": []
},
{
"id": "split_0_train_6132_entity",
"type": "progene_text",
"text": [
"sigma factor"
],
"offsets": [
[
114,
126
]
],
"normalized": []
},
{
"id": "split_0_train_6133_entity",
"type": "progene_text",
"text": [
"sigmaE"
],
"offsets": [
[
129,
135
]
],
"normalized": []
},
{
"id": "split_0_train_6134_entity",
"type": "progene_text",
"text": [
"sigma factor"
],
"offsets": [
[
184,
196
]
],
"normalized": []
},
{
"id": "split_0_train_6135_entity",
"type": "progene_text",
"text": [
"sigmaK"
],
"offsets": [
[
199,
205
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3852 | split_0_train_3852 | [
{
"id": "split_0_train_3852_passage",
"type": "progene_text",
"text": [
"Here , it is shown that the negative feedback loop does not require SinR , an inhibitor of sigE transcription ."
],
"offsets": [
[
0,
111
]
]
}
]
| [
{
"id": "split_0_train_6136_entity",
"type": "progene_text",
"text": [
"SinR"
],
"offsets": [
[
68,
72
]
],
"normalized": []
},
{
"id": "split_0_train_6137_entity",
"type": "progene_text",
"text": [
"sigE"
],
"offsets": [
[
91,
95
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3853 | split_0_train_3853 | [
{
"id": "split_0_train_3853_passage",
"type": "progene_text",
"text": [
"Production of sigmaK about 1 h earlier than normal does affect Spo0A , which when phosphorylated is an activator of sigE transcription ."
],
"offsets": [
[
0,
136
]
]
}
]
| [
{
"id": "split_0_train_6138_entity",
"type": "progene_text",
"text": [
"sigmaK"
],
"offsets": [
[
14,
20
]
],
"normalized": []
},
{
"id": "split_0_train_6139_entity",
"type": "progene_text",
"text": [
"Spo0A"
],
"offsets": [
[
63,
68
]
],
"normalized": []
},
{
"id": "split_0_train_6140_entity",
"type": "progene_text",
"text": [
"sigE"
],
"offsets": [
[
116,
120
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3854 | split_0_train_3854 | [
{
"id": "split_0_train_3854_passage",
"type": "progene_text",
"text": [
"A mutation in the spo0A gene , which bypasses the phosphorelay leading to the phosphorylation of Spo0A , diminished the negative effect of early sigmaK production on sigE expression early in sporulation ."
],
"offsets": [
[
0,
204
]
]
}
]
| [
{
"id": "split_0_train_6141_entity",
"type": "progene_text",
"text": [
"spo0A"
],
"offsets": [
[
18,
23
]
],
"normalized": []
},
{
"id": "split_0_train_6142_entity",
"type": "progene_text",
"text": [
"Spo0A"
],
"offsets": [
[
97,
102
]
],
"normalized": []
},
{
"id": "split_0_train_6143_entity",
"type": "progene_text",
"text": [
"sigmaK"
],
"offsets": [
[
145,
151
]
],
"normalized": []
},
{
"id": "split_0_train_6144_entity",
"type": "progene_text",
"text": [
"sigE"
],
"offsets": [
[
166,
170
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3855 | split_0_train_3855 | [
{
"id": "split_0_train_3855_passage",
"type": "progene_text",
"text": [
"Also , early production of sigmaK reduced expression of other Spo0A - dependent genes but not expression of the Spo0A - independent ald gene ."
],
"offsets": [
[
0,
142
]
]
}
]
| [
{
"id": "split_0_train_6145_entity",
"type": "progene_text",
"text": [
"sigmaK"
],
"offsets": [
[
27,
33
]
],
"normalized": []
},
{
"id": "split_0_train_6146_entity",
"type": "progene_text",
"text": [
"Spo0A"
],
"offsets": [
[
62,
67
]
],
"normalized": []
},
{
"id": "split_0_train_6147_entity",
"type": "progene_text",
"text": [
"Spo0A"
],
"offsets": [
[
112,
117
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3856 | split_0_train_3856 | [
{
"id": "split_0_train_3856_passage",
"type": "progene_text",
"text": [
"In contrast , both sigE and ald were overexpressed late in development of cells that fail to make sigmaK ."
],
"offsets": [
[
0,
106
]
]
}
]
| [
{
"id": "split_0_train_6148_entity",
"type": "progene_text",
"text": [
"sigE"
],
"offsets": [
[
19,
23
]
],
"normalized": []
},
{
"id": "split_0_train_6149_entity",
"type": "progene_text",
"text": [
"sigmaK"
],
"offsets": [
[
98,
104
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3857 | split_0_train_3857 | [
{
"id": "split_0_train_3857_passage",
"type": "progene_text",
"text": [
"The ald promoter , like the sigE promoter , is believed to be recognized by sigmaA RNA polymerase , suggesting that sigmaK may inhibit sigmaA activity late in sporulation ."
],
"offsets": [
[
0,
172
]
]
}
]
| [
{
"id": "split_0_train_6150_entity",
"type": "progene_text",
"text": [
"ald"
],
"offsets": [
[
4,
7
]
],
"normalized": []
},
{
"id": "split_0_train_6151_entity",
"type": "progene_text",
"text": [
"sigE"
],
"offsets": [
[
28,
32
]
],
"normalized": []
},
{
"id": "split_0_train_6152_entity",
"type": "progene_text",
"text": [
"sigmaA"
],
"offsets": [
[
76,
82
]
],
"normalized": []
},
{
"id": "split_0_train_6153_entity",
"type": "progene_text",
"text": [
"RNA polymerase"
],
"offsets": [
[
83,
97
]
],
"normalized": []
},
{
"id": "split_0_train_6154_entity",
"type": "progene_text",
"text": [
"sigmaK"
],
"offsets": [
[
116,
122
]
],
"normalized": []
},
{
"id": "split_0_train_6155_entity",
"type": "progene_text",
"text": [
"sigmaA"
],
"offsets": [
[
135,
141
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3858 | split_0_train_3858 | [
{
"id": "split_0_train_3858_passage",
"type": "progene_text",
"text": [
"To exert this negative effect , sigmaK must be transcriptionally active ."
],
"offsets": [
[
0,
73
]
]
}
]
| [
{
"id": "split_0_train_6156_entity",
"type": "progene_text",
"text": [
"sigmaK"
],
"offsets": [
[
32,
38
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3859 | split_0_train_3859 | [
{
"id": "split_0_train_3859_passage",
"type": "progene_text",
"text": [
"A mutant form of sigmaK that associates with core RNA polymerase , but does not direct transcription of a sigmaK - dependent gene , failed to negatively regulate expression of sigE or ald late in development ."
],
"offsets": [
[
0,
209
]
]
}
]
| [
{
"id": "split_0_train_6157_entity",
"type": "progene_text",
"text": [
"sigmaK"
],
"offsets": [
[
17,
23
]
],
"normalized": []
},
{
"id": "split_0_train_6158_entity",
"type": "progene_text",
"text": [
"RNA polymerase"
],
"offsets": [
[
50,
64
]
],
"normalized": []
},
{
"id": "split_0_train_6159_entity",
"type": "progene_text",
"text": [
"sigmaK"
],
"offsets": [
[
106,
112
]
],
"normalized": []
},
{
"id": "split_0_train_6160_entity",
"type": "progene_text",
"text": [
"sigE"
],
"offsets": [
[
176,
180
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3860 | split_0_train_3860 | [
{
"id": "split_0_train_3860_passage",
"type": "progene_text",
"text": [
"On the other hand , the negative effect of early sigmaK production on sigE expression early in sporulation did not require transcriptional activity of sigmaK RNA polymerase ."
],
"offsets": [
[
0,
174
]
]
}
]
| [
{
"id": "split_0_train_6161_entity",
"type": "progene_text",
"text": [
"sigmaK"
],
"offsets": [
[
49,
55
]
],
"normalized": []
},
{
"id": "split_0_train_6162_entity",
"type": "progene_text",
"text": [
"sigE"
],
"offsets": [
[
70,
74
]
],
"normalized": []
},
{
"id": "split_0_train_6163_entity",
"type": "progene_text",
"text": [
"sigmaK"
],
"offsets": [
[
151,
157
]
],
"normalized": []
},
{
"id": "split_0_train_6164_entity",
"type": "progene_text",
"text": [
"RNA polymerase"
],
"offsets": [
[
158,
172
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3861 | split_0_train_3861 | [
{
"id": "split_0_train_3861_passage",
"type": "progene_text",
"text": [
"These results demonstrate that sigmaK can negatively regulate sigE expression by two different mechanisms , one observed when sigmaK is produced earlier than normal , which does not require sigmaK to be transcriptionally active and affects Spo0A , and the other observed when sigmaK is produced at the normal time , which requires sigmaK RNA polymerase transcriptional activity ."
],
"offsets": [
[
0,
379
]
]
}
]
| [
{
"id": "split_0_train_6165_entity",
"type": "progene_text",
"text": [
"sigmaK"
],
"offsets": [
[
31,
37
]
],
"normalized": []
},
{
"id": "split_0_train_6166_entity",
"type": "progene_text",
"text": [
"sigE"
],
"offsets": [
[
62,
66
]
],
"normalized": []
},
{
"id": "split_0_train_6167_entity",
"type": "progene_text",
"text": [
"sigmaK"
],
"offsets": [
[
126,
132
]
],
"normalized": []
},
{
"id": "split_0_train_6168_entity",
"type": "progene_text",
"text": [
"sigmaK"
],
"offsets": [
[
190,
196
]
],
"normalized": []
},
{
"id": "split_0_train_6169_entity",
"type": "progene_text",
"text": [
"Spo0A"
],
"offsets": [
[
240,
245
]
],
"normalized": []
},
{
"id": "split_0_train_6170_entity",
"type": "progene_text",
"text": [
"sigmaK"
],
"offsets": [
[
276,
282
]
],
"normalized": []
},
{
"id": "split_0_train_6171_entity",
"type": "progene_text",
"text": [
"sigmaK"
],
"offsets": [
[
331,
337
]
],
"normalized": []
},
{
"id": "split_0_train_6172_entity",
"type": "progene_text",
"text": [
"RNA polymerase"
],
"offsets": [
[
338,
352
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3862 | split_0_train_3862 | [
{
"id": "split_0_train_3862_passage",
"type": "progene_text",
"text": [
"The latter mechanism facilitates the switch from sigmaE to sigmaK in the cascade controlling mother cell gene expression ."
],
"offsets": [
[
0,
122
]
]
}
]
| [
{
"id": "split_0_train_6173_entity",
"type": "progene_text",
"text": [
"sigmaE"
],
"offsets": [
[
49,
55
]
],
"normalized": []
},
{
"id": "split_0_train_6174_entity",
"type": "progene_text",
"text": [
"sigmaK"
],
"offsets": [
[
59,
65
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3863 | split_0_train_3863 | [
{
"id": "split_0_train_3863_passage",
"type": "progene_text",
"text": [
"Computer analysis of transcription regulatory patterns in completely sequenced bacterial genomes ."
],
"offsets": [
[
0,
98
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3864 | split_0_train_3864 | [
{
"id": "split_0_train_3864_passage",
"type": "progene_text",
"text": [
"Recognition of transcription regulation sites ( operators ) is a hard problem in computational molecular biology ."
],
"offsets": [
[
0,
114
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3865 | split_0_train_3865 | [
{
"id": "split_0_train_3865_passage",
"type": "progene_text",
"text": [
"In most cases , small sample size and low degree of sequence conservation preclude the construction of reliable recognition rules ."
],
"offsets": [
[
0,
131
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3866 | split_0_train_3866 | [
{
"id": "split_0_train_3866_passage",
"type": "progene_text",
"text": [
"We suggest an approach to this problem based on simultaneous analysis of several related genomes ."
],
"offsets": [
[
0,
98
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3867 | split_0_train_3867 | [
{
"id": "split_0_train_3867_passage",
"type": "progene_text",
"text": [
"It appears that as long as a gene coding for a transcription regulator is conserved in the compared bacterial genomes , the regulation of the respective group of genes ( regulons ) also tends to be maintained ."
],
"offsets": [
[
0,
210
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3868 | split_0_train_3868 | [
{
"id": "split_0_train_3868_passage",
"type": "progene_text",
"text": [
"Thus a gene can be confidently predicted to belong to a particular regulon in case not only itself , but also its orthologs in other genomes have candidate operators in the regulatory regions ."
],
"offsets": [
[
0,
193
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3869 | split_0_train_3869 | [
{
"id": "split_0_train_3869_passage",
"type": "progene_text",
"text": [
"This provides for a greater sensitivity of operator identification as even relatively weak signals are likely to be functionally relevant when conserved ."
],
"offsets": [
[
0,
154
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3870 | split_0_train_3870 | [
{
"id": "split_0_train_3870_passage",
"type": "progene_text",
"text": [
"We use this approach to analyze the purine ( PurR ) , arginine ( ArgR ) and aromatic amino acid ( TrpR and TyrR ) regulons of Escherichia coli and Haemophilus influenzae ."
],
"offsets": [
[
0,
171
]
]
}
]
| [
{
"id": "split_0_train_6175_entity",
"type": "progene_text",
"text": [
"PurR"
],
"offsets": [
[
45,
49
]
],
"normalized": []
},
{
"id": "split_0_train_6176_entity",
"type": "progene_text",
"text": [
"ArgR"
],
"offsets": [
[
65,
69
]
],
"normalized": []
},
{
"id": "split_0_train_6177_entity",
"type": "progene_text",
"text": [
"TrpR"
],
"offsets": [
[
98,
102
]
],
"normalized": []
},
{
"id": "split_0_train_6178_entity",
"type": "progene_text",
"text": [
"TyrR"
],
"offsets": [
[
107,
111
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3871 | split_0_train_3871 | [
{
"id": "split_0_train_3871_passage",
"type": "progene_text",
"text": [
"Candidate binding sites in regulatory regions of the respective H.influenzae genes are identified , a new family of purine transport proteins predicted to belong to the PurR regulon is described , and probable regulation of arginine transport by ArgR is demonstrated ."
],
"offsets": [
[
0,
268
]
]
}
]
| [
{
"id": "split_0_train_6179_entity",
"type": "progene_text",
"text": [
"family of purine transport proteins"
],
"offsets": [
[
106,
141
]
],
"normalized": []
},
{
"id": "split_0_train_6180_entity",
"type": "progene_text",
"text": [
"PurR"
],
"offsets": [
[
169,
173
]
],
"normalized": []
},
{
"id": "split_0_train_6181_entity",
"type": "progene_text",
"text": [
"ArgR"
],
"offsets": [
[
246,
250
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3872 | split_0_train_3872 | [
{
"id": "split_0_train_3872_passage",
"type": "progene_text",
"text": [
"Differences in the regulation of some orthologous genes in E.coli and H.influenzae , in particular the apparent lack of the autoregulation of the purine repressor gene in H.influenzae , are demonstrated ."
],
"offsets": [
[
0,
204
]
]
}
]
| [
{
"id": "split_0_train_6182_entity",
"type": "progene_text",
"text": [
"purine repressor"
],
"offsets": [
[
146,
162
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3873 | split_0_train_3873 | [
{
"id": "split_0_train_3873_passage",
"type": "progene_text",
"text": [
"Cellular activity in the gallbladder of children with anomalous arrangement of the pancreaticobiliary duct ."
],
"offsets": [
[
0,
108
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3874 | split_0_train_3874 | [
{
"id": "split_0_train_3874_passage",
"type": "progene_text",
"text": [
"BACKGROUND / PURPOSE :"
],
"offsets": [
[
0,
22
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3875 | split_0_train_3875 | [
{
"id": "split_0_train_3875_passage",
"type": "progene_text",
"text": [
"Anomalous arrangement of the pancreaticobiliary duct ( AAPBD ) is closely related to congenital biliary dilatation and frequently associated with biliary tract malignancy ."
],
"offsets": [
[
0,
172
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3876 | split_0_train_3876 | [
{
"id": "split_0_train_3876_passage",
"type": "progene_text",
"text": [
"To examine the mechanism of biliary tract carcinogenesis in patients with AAPBD , we investigated histologically the early changes in cell proliferative kinetics of the gallbladder mucosa of children with AAPBD ."
],
"offsets": [
[
0,
212
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3877 | split_0_train_3877 | [
{
"id": "split_0_train_3877_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3878 | split_0_train_3878 | [
{
"id": "split_0_train_3878_passage",
"type": "progene_text",
"text": [
"Twenty-three specimens of gallbladder were obtained from 23 children with AAPBD , and six control specimens were obtained from pediatric patients ."
],
"offsets": [
[
0,
147
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3879 | split_0_train_3879 | [
{
"id": "split_0_train_3879_passage",
"type": "progene_text",
"text": [
"All specimens were fixed routinely and paraffin embedded and examined histologically with H&E staining and immunohistochemically with monoclonal antibody Ki-67 ( MIB-1 ) , which reacts with a human nuclear antigen associated with cell proliferation ."
],
"offsets": [
[
0,
250
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3880 | split_0_train_3880 | [
{
"id": "split_0_train_3880_passage",
"type": "progene_text",
"text": [
"Ki-67 labeling index ( Ki-67 LI ) was obtained by counting the numbers of Ki-67 - positive cells per 1,000 gallbladder epithelial cells ."
],
"offsets": [
[
0,
137
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3881 | split_0_train_3881 | [
{
"id": "split_0_train_3881_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3882 | split_0_train_3882 | [
{
"id": "split_0_train_3882_passage",
"type": "progene_text",
"text": [
"Significant differences in Ki-67 LI were noted between children with and without AAPBD ."
],
"offsets": [
[
0,
88
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3883 | split_0_train_3883 | [
{
"id": "split_0_train_3883_passage",
"type": "progene_text",
"text": [
"Furthermore , Ki-67 LI and the incidence of epithelial hyperplasia of gallbladder were significantly higher in children with AAPBD in whom the major pancreatic duct joined the common bile duct ( P-C type ) than in those in whom the common bile duct joined the major pancreatic duct ( C-P type ) ."
],
"offsets": [
[
0,
296
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3884 | split_0_train_3884 | [
{
"id": "split_0_train_3884_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3885 | split_0_train_3885 | [
{
"id": "split_0_train_3885_passage",
"type": "progene_text",
"text": [
"Cellular proliferative activity was increased in children with AAPBD , especially those with the P-C - type anomaly ."
],
"offsets": [
[
0,
117
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3886 | split_0_train_3886 | [
{
"id": "split_0_train_3886_passage",
"type": "progene_text",
"text": [
"These results suggest that the early mucosal changes of the gallbladder occurred in early childhood of patients with AAPBD and might be associated with gallbladder cancer ."
],
"offsets": [
[
0,
172
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3887 | split_0_train_3887 | [
{
"id": "split_0_train_3887_passage",
"type": "progene_text",
"text": [
"Early diagnosis and early surgical division of the biliary tract and pancreatic duct is recommended for children with AAPBD ."
],
"offsets": [
[
0,
125
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3888 | split_0_train_3888 | [
{
"id": "split_0_train_3888_passage",
"type": "progene_text",
"text": [
"A G - box element from the Catharanthus roseus strictosidine synthase ( Str ) gene promoter confers seed - specific expression in transgenic tobacco plants ."
],
"offsets": [
[
0,
157
]
]
}
]
| [
{
"id": "split_0_train_6183_entity",
"type": "progene_text",
"text": [
"strictosidine synthase"
],
"offsets": [
[
47,
69
]
],
"normalized": []
},
{
"id": "split_0_train_6184_entity",
"type": "progene_text",
"text": [
"Str"
],
"offsets": [
[
72,
75
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3889 | split_0_train_3889 | [
{
"id": "split_0_train_3889_passage",
"type": "progene_text",
"text": [
"The enzyme encoded by the strictosidine synthase ( Str ) gene from Catharanthus roseus catalyses a key step in the biosynthesis of the pharmaceutically important terpenoid indole alkaloids ."
],
"offsets": [
[
0,
190
]
]
}
]
| [
{
"id": "split_0_train_6185_entity",
"type": "progene_text",
"text": [
"strictosidine synthase"
],
"offsets": [
[
26,
48
]
],
"normalized": []
},
{
"id": "split_0_train_6186_entity",
"type": "progene_text",
"text": [
"Str"
],
"offsets": [
[
51,
54
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3890 | split_0_train_3890 | [
{
"id": "split_0_train_3890_passage",
"type": "progene_text",
"text": [
"Str cDNA and genomic clones have already been isolated , allowing us to study the regulation of Str gene expression ."
],
"offsets": [
[
0,
117
]
]
}
]
| [
{
"id": "split_0_train_6187_entity",
"type": "progene_text",
"text": [
"Str"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_6188_entity",
"type": "progene_text",
"text": [
"Str"
],
"offsets": [
[
96,
99
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3891 | split_0_train_3891 | [
{
"id": "split_0_train_3891_passage",
"type": "progene_text",
"text": [
"Here we focus on the role of a putative cis - acting element , CACGTG , in the Str promoter ."
],
"offsets": [
[
0,
93
]
]
}
]
| [
{
"id": "split_0_train_6189_entity",
"type": "progene_text",
"text": [
"Str"
],
"offsets": [
[
79,
82
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3892 | split_0_train_3892 | [
{
"id": "split_0_train_3892_passage",
"type": "progene_text",
"text": [
"This sequence is known as a G-box , and functions as a transcription - regulating sequence in a number of other promoters ."
],
"offsets": [
[
0,
123
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3893 | split_0_train_3893 | [
{
"id": "split_0_train_3893_passage",
"type": "progene_text",
"text": [
"By means of electrophoretic mobility shift assays it was demonstrated that the Str G-box is capable of interacting with nuclear factors in tobacco and with the cloned tobacco G-box - binding factor TAF-1 ."
],
"offsets": [
[
0,
205
]
]
}
]
| [
{
"id": "split_0_train_6190_entity",
"type": "progene_text",
"text": [
"Str"
],
"offsets": [
[
79,
82
]
],
"normalized": []
},
{
"id": "split_0_train_6191_entity",
"type": "progene_text",
"text": [
"TAF-1"
],
"offsets": [
[
198,
203
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3894 | split_0_train_3894 | [
{
"id": "split_0_train_3894_passage",
"type": "progene_text",
"text": [
"Disruption of the Str G - box sequence by two single - nucleotide mutations prevented binding of factors , thereby demonstrating the specificity of the observed interactions ."
],
"offsets": [
[
0,
175
]
]
}
]
| [
{
"id": "split_0_train_6192_entity",
"type": "progene_text",
"text": [
"Str"
],
"offsets": [
[
18,
21
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3895 | split_0_train_3895 | [
{
"id": "split_0_train_3895_passage",
"type": "progene_text",
"text": [
"Functional analysis in transgenic tobacco plants demonstrated that these mutations also reduced the transcriptional activity of constructs containing tetramers of the Str G - box sequence ."
],
"offsets": [
[
0,
189
]
]
}
]
| [
{
"id": "split_0_train_6193_entity",
"type": "progene_text",
"text": [
"Str"
],
"offsets": [
[
167,
170
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3896 | split_0_train_3896 | [
{
"id": "split_0_train_3896_passage",
"type": "progene_text",
"text": [
"Expression directed by a tetramer of the Str G - box fused to a truncated promoter containing only a TATA box was confined to seeds and was found to increase during seed maturation ."
],
"offsets": [
[
0,
182
]
]
}
]
| [
{
"id": "split_0_train_6194_entity",
"type": "progene_text",
"text": [
"Str"
],
"offsets": [
[
41,
44
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3897 | split_0_train_3897 | [
{
"id": "split_0_train_3897_passage",
"type": "progene_text",
"text": [
"Thus , the Str G-box tetramer is able to direct seed - specific expression independently of other regulatory sequences ."
],
"offsets": [
[
0,
120
]
]
}
]
| [
{
"id": "split_0_train_6195_entity",
"type": "progene_text",
"text": [
"Str"
],
"offsets": [
[
11,
14
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3898 | split_0_train_3898 | [
{
"id": "split_0_train_3898_passage",
"type": "progene_text",
"text": [
"G-box-directed expression in leaves required the presence of an enhancer region from the cauliflower mosaic virus ( CaMV ) 35S promoter ."
],
"offsets": [
[
0,
137
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3899 | split_0_train_3899 | [
{
"id": "split_0_train_3899_passage",
"type": "progene_text",
"text": [
"The results indicate that the G-box needs to interact with other elements to drive expression in leaf , and that it can by itself confer seed - specific expression as a multimer ."
],
"offsets": [
[
0,
179
]
]
}
]
| []
| []
| []
| []
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.