id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_3900 | split_0_train_3900 | [
{
"id": "split_0_train_3900_passage",
"type": "progene_text",
"text": [
"The fact that only some of the G - boxes found in different promoters serve as seed - specific elements indicates that sequences flanking the G-box determine the transcriptional activity in different tissues ."
],
"offsets": [
[
0,
209
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3901 | split_0_train_3901 | [
{
"id": "split_0_train_3901_passage",
"type": "progene_text",
"text": [
"Based on sequence comparisons we propose that the nucleotides at positions - 4 , - 3 , - 2 and/or + 4 are important in determining seed - specific expression ."
],
"offsets": [
[
0,
159
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3902 | split_0_train_3902 | [
{
"id": "split_0_train_3902_passage",
"type": "progene_text",
"text": [
"The identification of alcohol dependence criteria in the general population ."
],
"offsets": [
[
0,
77
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3903 | split_0_train_3903 | [
{
"id": "split_0_train_3903_passage",
"type": "progene_text",
"text": [
"AIMS :"
],
"offsets": [
[
0,
6
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3904 | split_0_train_3904 | [
{
"id": "split_0_train_3904_passage",
"type": "progene_text",
"text": [
"To assess the criteria used to identify alcohol dependence in the general population ."
],
"offsets": [
[
0,
86
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3905 | split_0_train_3905 | [
{
"id": "split_0_train_3905_passage",
"type": "progene_text",
"text": [
"DESIGN AND SETTING :"
],
"offsets": [
[
0,
20
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3906 | split_0_train_3906 | [
{
"id": "split_0_train_3906_passage",
"type": "progene_text",
"text": [
"Two independent probability surveys of the US household population 18 years of age and older were analyzed : the 1994 National Telephone Survey ( NTS-94 ) , which interviewed 637 respondents , and the 1988 National Household Interview Survey ( NHIS-88 ) which interviewed 43 , 809 respondents in their homes ."
],
"offsets": [
[
0,
309
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3907 | split_0_train_3907 | [
{
"id": "split_0_train_3907_passage",
"type": "progene_text",
"text": [
"PARTICIPANTS :"
],
"offsets": [
[
0,
14
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3908 | split_0_train_3908 | [
{
"id": "split_0_train_3908_passage",
"type": "progene_text",
"text": [
"The analyses of the NHIS-88 dataset focused on drinkers who consumed at least 12 drinks of alcohol in the 12 months prior to the survey interview ( N = 22 , 102 ) ."
],
"offsets": [
[
0,
164
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3909 | split_0_train_3909 | [
{
"id": "split_0_train_3909_passage",
"type": "progene_text",
"text": [
"The analyses of the NTS-94 dataset focused on drinkers who consumed at least one drink in the 12 months prior to the survey interview ( N = 637 ) ."
],
"offsets": [
[
0,
147
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3910 | split_0_train_3910 | [
{
"id": "split_0_train_3910_passage",
"type": "progene_text",
"text": [
"MEASUREMENTS :"
],
"offsets": [
[
0,
14
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3911 | split_0_train_3911 | [
{
"id": "split_0_train_3911_passage",
"type": "progene_text",
"text": [
"Criteria for DSM-IV alcohol dependence were operationalized using 15 items from a standardized questionnaire ."
],
"offsets": [
[
0,
110
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3912 | split_0_train_3912 | [
{
"id": "split_0_train_3912_passage",
"type": "progene_text",
"text": [
"FINDINGS :"
],
"offsets": [
[
0,
10
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3913 | split_0_train_3913 | [
{
"id": "split_0_train_3913_passage",
"type": "progene_text",
"text": [
"Analyses suggested that normal drinking behavior can be misidentified as dependence criteria ."
],
"offsets": [
[
0,
94
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3914 | split_0_train_3914 | [
{
"id": "split_0_train_3914_passage",
"type": "progene_text",
"text": [
"Results for men who drank up to two drinks per day suggest that if the dependence criteria were invalid , reductions in the prevalence of specific indicators of alcohol dependence would range from 0.3 % to 5.2 % ."
],
"offsets": [
[
0,
213
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3915 | split_0_train_3915 | [
{
"id": "split_0_train_3915_passage",
"type": "progene_text",
"text": [
"Correcting for the misidentification of alcohol dependence diagnosis would reduce the overall prevalence of alcohol dependence by 0.5 % ."
],
"offsets": [
[
0,
137
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3916 | split_0_train_3916 | [
{
"id": "split_0_train_3916_passage",
"type": "progene_text",
"text": [
"Up to 7 % of the men could have been diagnosed as alcohol - dependent and could have provided invalid reports ."
],
"offsets": [
[
0,
111
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3917 | split_0_train_3917 | [
{
"id": "split_0_train_3917_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3918 | split_0_train_3918 | [
{
"id": "split_0_train_3918_passage",
"type": "progene_text",
"text": [
"The identification of alcohol dependence in general population samples must include careful probing of the nature of drinking - related behavior reported by respondents ."
],
"offsets": [
[
0,
170
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3919 | split_0_train_3919 | [
{
"id": "split_0_train_3919_passage",
"type": "progene_text",
"text": [
"This will decrease misidentification of dependence criteria , increasing the validity of dependence diagnosis in survey research ."
],
"offsets": [
[
0,
130
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3920 | split_0_train_3920 | [
{
"id": "split_0_train_3920_passage",
"type": "progene_text",
"text": [
"Structural and functional analysis of the control region of the human DNA topoisomerase II alpha gene in drug - resistant cells ."
],
"offsets": [
[
0,
129
]
]
}
]
| [
{
"id": "split_0_train_6196_entity",
"type": "progene_text",
"text": [
"DNA topoisomerase II alpha"
],
"offsets": [
[
70,
96
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3921 | split_0_train_3921 | [
{
"id": "split_0_train_3921_passage",
"type": "progene_text",
"text": [
"We have previously shown that the DNA topoisomerase II alpha ( topo II alpha ) gene is down - regulated in VP16 / VM26 - resistant cells at the transcriptional level ."
],
"offsets": [
[
0,
167
]
]
}
]
| [
{
"id": "split_0_train_6197_entity",
"type": "progene_text",
"text": [
"DNA topoisomerase II alpha"
],
"offsets": [
[
34,
60
]
],
"normalized": []
},
{
"id": "split_0_train_6198_entity",
"type": "progene_text",
"text": [
"topo II alpha"
],
"offsets": [
[
63,
76
]
],
"normalized": []
},
{
"id": "split_0_train_6199_entity",
"type": "progene_text",
"text": [
"VP16"
],
"offsets": [
[
107,
111
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3922 | split_0_train_3922 | [
{
"id": "split_0_train_3922_passage",
"type": "progene_text",
"text": [
"To determine the DNA elements responsible for down - regulation , the transcriptional activities of luciferase reporter constructs containing various lengths of the promoter sequences were investigated by transient transfection of two resistant cell lines , KB / VP2 and KB / VM4 ."
],
"offsets": [
[
0,
281
]
]
}
]
| [
{
"id": "split_0_train_6200_entity",
"type": "progene_text",
"text": [
"luciferase"
],
"offsets": [
[
100,
110
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3923 | split_0_train_3923 | [
{
"id": "split_0_train_3923_passage",
"type": "progene_text",
"text": [
"The transcriptional activities of the full - length promoter (-295 to + 85 ) and of three deletion constructs (-197 , - 154 and - 74 to + 85 ) were significantly down - regulated in resistant cells ."
],
"offsets": [
[
0,
199
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3924 | split_0_train_3924 | [
{
"id": "split_0_train_3924_passage",
"type": "progene_text",
"text": [
"In contrast , the transcriptional activity of the minimal promoter (-20 to + 85 ) in resistant cells was similar to that in parental KB cells ."
],
"offsets": [
[
0,
143
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3925 | split_0_train_3925 | [
{
"id": "split_0_train_3925_passage",
"type": "progene_text",
"text": [
"Furthermore , introduction of a mutation in ICE1 abolished the down - regulation of the topo II alpha promoter activity in drug - resistant cells ."
],
"offsets": [
[
0,
147
]
]
}
]
| [
{
"id": "split_0_train_6201_entity",
"type": "progene_text",
"text": [
"topo II alpha"
],
"offsets": [
[
88,
101
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3926 | split_0_train_3926 | [
{
"id": "split_0_train_3926_passage",
"type": "progene_text",
"text": [
"In vivo footprinting analysis of topo II alpha gene promoter revealed several specific protein - binding sites , a GC box , ICE1 , ICE2 and ICE3 ."
],
"offsets": [
[
0,
146
]
]
}
]
| [
{
"id": "split_0_train_6202_entity",
"type": "progene_text",
"text": [
"topo II alpha"
],
"offsets": [
[
33,
46
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3927 | split_0_train_3927 | [
{
"id": "split_0_train_3927_passage",
"type": "progene_text",
"text": [
"In vivo footprinting analysis also identified a cluster of hypersensitive sites ."
],
"offsets": [
[
0,
81
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3928 | split_0_train_3928 | [
{
"id": "split_0_train_3928_passage",
"type": "progene_text",
"text": [
"However , there was no marked difference in protein - binding sites between parental and resistant cells ."
],
"offsets": [
[
0,
106
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3929 | split_0_train_3929 | [
{
"id": "split_0_train_3929_passage",
"type": "progene_text",
"text": [
"To confirm our previous results , we have established the VP16 - resistant cell lines T12 - VP1 and T12 - VP2 from T12 cells derived from human bladder cancer T24 cells stably transfected with the chloramphenicol acetyltransferase reporter gene driven by the topo II alpha gene promoter ."
],
"offsets": [
[
0,
288
]
]
}
]
| [
{
"id": "split_0_train_6203_entity",
"type": "progene_text",
"text": [
"VP16"
],
"offsets": [
[
58,
62
]
],
"normalized": []
},
{
"id": "split_0_train_6204_entity",
"type": "progene_text",
"text": [
"chloramphenicol acetyltransferase"
],
"offsets": [
[
197,
230
]
],
"normalized": []
},
{
"id": "split_0_train_6205_entity",
"type": "progene_text",
"text": [
"topo II alpha"
],
"offsets": [
[
259,
272
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3930 | split_0_train_3930 | [
{
"id": "split_0_train_3930_passage",
"type": "progene_text",
"text": [
"The expression to topo II alpha was down - regulated in both cell lines ."
],
"offsets": [
[
0,
73
]
]
}
]
| [
{
"id": "split_0_train_6206_entity",
"type": "progene_text",
"text": [
"topo II alpha"
],
"offsets": [
[
18,
31
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3931 | split_0_train_3931 | [
{
"id": "split_0_train_3931_passage",
"type": "progene_text",
"text": [
"We also found that CAT gene expression was significantly decreased to one - fifth of that in T12 parental cells ."
],
"offsets": [
[
0,
113
]
]
}
]
| [
{
"id": "split_0_train_6207_entity",
"type": "progene_text",
"text": [
"CAT"
],
"offsets": [
[
19,
22
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3932 | split_0_train_3932 | [
{
"id": "split_0_train_3932_passage",
"type": "progene_text",
"text": [
"These results suggest that the expression of the topo II alpha gene requires the binding of multiple factors to the core promoter and is down - regulated at the transcriptional level , probably through binding of a negative factor to ICE1 in drug - resistant cells ."
],
"offsets": [
[
0,
266
]
]
}
]
| [
{
"id": "split_0_train_6208_entity",
"type": "progene_text",
"text": [
"topo II alpha"
],
"offsets": [
[
49,
62
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3933 | split_0_train_3933 | [
{
"id": "split_0_train_3933_passage",
"type": "progene_text",
"text": [
"Promoter activity of the beta-amyloid precursor protein gene is negatively modulated by an upstream regulatory element ."
],
"offsets": [
[
0,
120
]
]
}
]
| [
{
"id": "split_0_train_6209_entity",
"type": "progene_text",
"text": [
"beta-amyloid precursor protein"
],
"offsets": [
[
25,
55
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3934 | split_0_train_3934 | [
{
"id": "split_0_train_3934_passage",
"type": "progene_text",
"text": [
"Alzheimer 's disease ( AD ) is characterized by the aggregation of the amyloid beta-peptide ( Abeta ) which is generated from a larger beta-amyloid precursor protein ( betaAPP ) ."
],
"offsets": [
[
0,
179
]
]
}
]
| [
{
"id": "split_0_train_6210_entity",
"type": "progene_text",
"text": [
"amyloid beta-peptide"
],
"offsets": [
[
71,
91
]
],
"normalized": []
},
{
"id": "split_0_train_6211_entity",
"type": "progene_text",
"text": [
"Abeta"
],
"offsets": [
[
94,
99
]
],
"normalized": []
},
{
"id": "split_0_train_6212_entity",
"type": "progene_text",
"text": [
"beta-amyloid precursor protein"
],
"offsets": [
[
135,
165
]
],
"normalized": []
},
{
"id": "split_0_train_6213_entity",
"type": "progene_text",
"text": [
"betaAPP"
],
"offsets": [
[
168,
175
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3935 | split_0_train_3935 | [
{
"id": "split_0_train_3935_passage",
"type": "progene_text",
"text": [
"An overexpression of the betaAPP gene in certain areas of the AD brain has been suggested to be an important factor in the neuropathology of AD ."
],
"offsets": [
[
0,
145
]
]
}
]
| [
{
"id": "split_0_train_6214_entity",
"type": "progene_text",
"text": [
"betaAPP"
],
"offsets": [
[
25,
32
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3936 | split_0_train_3936 | [
{
"id": "split_0_train_3936_passage",
"type": "progene_text",
"text": [
"Here we have further characterized an upstream regulatory element ( URE ) located between - 2257 and - 2234 of the human betaAPP promoter ."
],
"offsets": [
[
0,
139
]
]
}
]
| [
{
"id": "split_0_train_6215_entity",
"type": "progene_text",
"text": [
"betaAPP"
],
"offsets": [
[
121,
128
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3937 | split_0_train_3937 | [
{
"id": "split_0_train_3937_passage",
"type": "progene_text",
"text": [
"In addition to its location in the promoter , BLAST search reveals that URE is present in several introns of the betaAPP gene and is also detected in many other genes ."
],
"offsets": [
[
0,
168
]
]
}
]
| [
{
"id": "split_0_train_6216_entity",
"type": "progene_text",
"text": [
"betaAPP"
],
"offsets": [
[
113,
120
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3938 | split_0_train_3938 | [
{
"id": "split_0_train_3938_passage",
"type": "progene_text",
"text": [
"For functional studies , two promoter regions were cloned upstream of the reporter gene , chloramphenicol acetyl transferase ( CAT ) : (i) phbetaE-B - the plasmid that contains the human (h) promoter region ( - 2832 to + 101 ) including URE , and (ii) prhbetaE-B - the plasmid that contains the rhesus ( rh ) promoter region excluding URE as it lacks a 270 bp region of the hbetaAPP promoter (-2435 to - 2165 ) ."
],
"offsets": [
[
0,
412
]
]
}
]
| [
{
"id": "split_0_train_6217_entity",
"type": "progene_text",
"text": [
"chloramphenicol acetyl transferase"
],
"offsets": [
[
90,
124
]
],
"normalized": []
},
{
"id": "split_0_train_6218_entity",
"type": "progene_text",
"text": [
"CAT"
],
"offsets": [
[
127,
130
]
],
"normalized": []
},
{
"id": "split_0_train_6219_entity",
"type": "progene_text",
"text": [
"hbetaAPP"
],
"offsets": [
[
374,
382
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3939 | split_0_train_3939 | [
{
"id": "split_0_train_3939_passage",
"type": "progene_text",
"text": [
"Transient transfection studies indicate that phbetaE-B displayed significantly less CAT - promoter activity than prhbetaE-B in C6 , PC12 and SK-N-SH cells ."
],
"offsets": [
[
0,
156
]
]
}
]
| [
{
"id": "split_0_train_6220_entity",
"type": "progene_text",
"text": [
"CAT"
],
"offsets": [
[
84,
87
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3940 | split_0_train_3940 | [
{
"id": "split_0_train_3940_passage",
"type": "progene_text",
"text": [
"To determine the role of URE in a heterologous promoter , a pbetaURE construct was made by subcloning URE in an enhancerless promoter vector pCATP ."
],
"offsets": [
[
0,
148
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3941 | split_0_train_3941 | [
{
"id": "split_0_train_3941_passage",
"type": "progene_text",
"text": [
"The pbetaURE - CAT construct displayed threefold to fourfold less promoter activity than pCATP when different cell lines were transfected with the plasmids ."
],
"offsets": [
[
0,
157
]
]
}
]
| [
{
"id": "split_0_train_6221_entity",
"type": "progene_text",
"text": [
"CAT"
],
"offsets": [
[
15,
18
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3942 | split_0_train_3942 | [
{
"id": "split_0_train_3942_passage",
"type": "progene_text",
"text": [
"URE interacts with a novel protein(s) as determined by the electrophoretic mobility shift assay ( EMSA ) ."
],
"offsets": [
[
0,
106
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3943 | split_0_train_3943 | [
{
"id": "split_0_train_3943_passage",
"type": "progene_text",
"text": [
"Although the core DNA region of URE resembles with the NF-kB element , URE - binding protein is not related to the NF-kB transcription factor ."
],
"offsets": [
[
0,
143
]
]
}
]
| [
{
"id": "split_0_train_6222_entity",
"type": "progene_text",
"text": [
"NF-kB"
],
"offsets": [
[
55,
60
]
],
"normalized": []
},
{
"id": "split_0_train_6223_entity",
"type": "progene_text",
"text": [
"NF-kB"
],
"offsets": [
[
115,
120
]
],
"normalized": []
},
{
"id": "split_0_train_6224_entity",
"type": "progene_text",
"text": [
"transcription factor"
],
"offsets": [
[
121,
141
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3944 | split_0_train_3944 | [
{
"id": "split_0_train_3944_passage",
"type": "progene_text",
"text": [
"When EMSA was performed with specific competitors in different cell lines , the labeled URE probe was not competed by the oligonucleotides specific for either the AP3 , NF-1 or NF-kB transcription factor ."
],
"offsets": [
[
0,
205
]
]
}
]
| [
{
"id": "split_0_train_6225_entity",
"type": "progene_text",
"text": [
"AP3"
],
"offsets": [
[
163,
166
]
],
"normalized": []
},
{
"id": "split_0_train_6226_entity",
"type": "progene_text",
"text": [
"NF-1"
],
"offsets": [
[
169,
173
]
],
"normalized": []
},
{
"id": "split_0_train_6227_entity",
"type": "progene_text",
"text": [
"NF-kB"
],
"offsets": [
[
177,
182
]
],
"normalized": []
},
{
"id": "split_0_train_6228_entity",
"type": "progene_text",
"text": [
"transcription factor"
],
"offsets": [
[
183,
203
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3945 | split_0_train_3945 | [
{
"id": "split_0_train_3945_passage",
"type": "progene_text",
"text": [
"The migration of the URE - protein complex was different from the NF-kB - protein complex in the EMSA gel ."
],
"offsets": [
[
0,
107
]
]
}
]
| [
{
"id": "split_0_train_6229_entity",
"type": "progene_text",
"text": [
"NF-kB"
],
"offsets": [
[
66,
71
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3946 | split_0_train_3946 | [
{
"id": "split_0_train_3946_passage",
"type": "progene_text",
"text": [
"A distinct URE - specific nuclear factor was also detected in frontal cortex of a normal human brain ."
],
"offsets": [
[
0,
102
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3947 | split_0_train_3947 | [
{
"id": "split_0_train_3947_passage",
"type": "progene_text",
"text": [
"These results suggest that the URE region acts as a repressor element , that the URE - binding protein is not related to the known transcription factors tested , and that the protein is present in astrocytic , neuroblastoma , PC12 cells and in the human brain ."
],
"offsets": [
[
0,
261
]
]
}
]
| [
{
"id": "split_0_train_6230_entity",
"type": "progene_text",
"text": [
"transcription factors"
],
"offsets": [
[
131,
152
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3948 | split_0_train_3948 | [
{
"id": "split_0_train_3948_passage",
"type": "progene_text",
"text": [
"The first ATPase domain of the yeast 246 - kDa protein is required for in vivo unwinding of the U4 / U6 duplex ."
],
"offsets": [
[
0,
112
]
]
}
]
| [
{
"id": "split_0_train_6231_entity",
"type": "progene_text",
"text": [
"ATPase"
],
"offsets": [
[
10,
16
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3949 | split_0_train_3949 | [
{
"id": "split_0_train_3949_passage",
"type": "progene_text",
"text": [
"The yeast PRP44 gene , alternatively named as BRR2 , SLT22 , RSS1 , or SNU246 , encodes a 246 - kDa protein with putative RNA helicase function during pre - mRNA splicing ."
],
"offsets": [
[
0,
172
]
]
}
]
| [
{
"id": "split_0_train_6232_entity",
"type": "progene_text",
"text": [
"PRP44"
],
"offsets": [
[
10,
15
]
],
"normalized": []
},
{
"id": "split_0_train_6233_entity",
"type": "progene_text",
"text": [
"BRR2"
],
"offsets": [
[
46,
50
]
],
"normalized": []
},
{
"id": "split_0_train_6234_entity",
"type": "progene_text",
"text": [
"SLT22"
],
"offsets": [
[
53,
58
]
],
"normalized": []
},
{
"id": "split_0_train_6235_entity",
"type": "progene_text",
"text": [
"RSS1"
],
"offsets": [
[
61,
65
]
],
"normalized": []
},
{
"id": "split_0_train_6236_entity",
"type": "progene_text",
"text": [
"SNU246"
],
"offsets": [
[
71,
77
]
],
"normalized": []
},
{
"id": "split_0_train_6237_entity",
"type": "progene_text",
"text": [
"RNA helicase"
],
"offsets": [
[
122,
134
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3950 | split_0_train_3950 | [
{
"id": "split_0_train_3950_passage",
"type": "progene_text",
"text": [
"The protein is a typical DEAD / H family member , but unlike most other members of this family , it contains two putative RNA helicase domains , each with a highly conserved ATPase motif ."
],
"offsets": [
[
0,
188
]
]
}
]
| [
{
"id": "split_0_train_6238_entity",
"type": "progene_text",
"text": [
"RNA helicase"
],
"offsets": [
[
122,
134
]
],
"normalized": []
},
{
"id": "split_0_train_6239_entity",
"type": "progene_text",
"text": [
"ATPase"
],
"offsets": [
[
174,
180
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3951 | split_0_train_3951 | [
{
"id": "split_0_train_3951_passage",
"type": "progene_text",
"text": [
"Prior to this study little was known about functional roles for these two domains ."
],
"offsets": [
[
0,
83
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3952 | split_0_train_3952 | [
{
"id": "split_0_train_3952_passage",
"type": "progene_text",
"text": [
"We present genetic and biochemical evidence that ATPase motifs of only the first helicase domain are required for cell viability and pre - mRNA splicing ."
],
"offsets": [
[
0,
154
]
]
}
]
| [
{
"id": "split_0_train_6240_entity",
"type": "progene_text",
"text": [
"ATPase"
],
"offsets": [
[
49,
55
]
],
"normalized": []
},
{
"id": "split_0_train_6241_entity",
"type": "progene_text",
"text": [
"helicase"
],
"offsets": [
[
81,
89
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3953 | split_0_train_3953 | [
{
"id": "split_0_train_3953_passage",
"type": "progene_text",
"text": [
"Overexpression of mutations in the first domain results in a dominant negative phenotype , and extracts from these mutant strains inhibit in vitro pre - mRNA splicing ."
],
"offsets": [
[
0,
168
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3954 | split_0_train_3954 | [
{
"id": "split_0_train_3954_passage",
"type": "progene_text",
"text": [
"In vitro analyses of affinity purified proteins revealed that only the first helicase domain possesses poly ( U ) - dependent ATPase activity ."
],
"offsets": [
[
0,
143
]
]
}
]
| [
{
"id": "split_0_train_6242_entity",
"type": "progene_text",
"text": [
"helicase"
],
"offsets": [
[
77,
85
]
],
"normalized": []
},
{
"id": "split_0_train_6243_entity",
"type": "progene_text",
"text": [
"ATPase"
],
"offsets": [
[
126,
132
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3955 | split_0_train_3955 | [
{
"id": "split_0_train_3955_passage",
"type": "progene_text",
"text": [
"Overexpression of a dominant negative protein in vivo reduces the relative abundance of free U4 and U6 snRNA with a concomitant accumulation of the U4 / U6 duplex ."
],
"offsets": [
[
0,
164
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3956 | split_0_train_3956 | [
{
"id": "split_0_train_3956_passage",
"type": "progene_text",
"text": [
"Accumulation of the U4 / U6 duplex was relieved by overexpression of wild - type Prp44p ."
],
"offsets": [
[
0,
89
]
]
}
]
| [
{
"id": "split_0_train_6244_entity",
"type": "progene_text",
"text": [
"Prp44p"
],
"offsets": [
[
81,
87
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3957 | split_0_train_3957 | [
{
"id": "split_0_train_3957_passage",
"type": "progene_text",
"text": [
"Three DEAD / H box proteins , Prp16p , Prp22p and Prp44p , have previously been shown to affect U4 / U6 unwinding activity in vitro ."
],
"offsets": [
[
0,
133
]
]
}
]
| [
{
"id": "split_0_train_6245_entity",
"type": "progene_text",
"text": [
"Prp16p"
],
"offsets": [
[
30,
36
]
],
"normalized": []
},
{
"id": "split_0_train_6246_entity",
"type": "progene_text",
"text": [
"Prp22p"
],
"offsets": [
[
39,
45
]
],
"normalized": []
},
{
"id": "split_0_train_6247_entity",
"type": "progene_text",
"text": [
"Prp44p"
],
"offsets": [
[
50,
56
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3958 | split_0_train_3958 | [
{
"id": "split_0_train_3958_passage",
"type": "progene_text",
"text": [
"The possible role of these proteins in mediating this reaction in vivo was explored following induced expression of ATPase domain mutants in each of these ."
],
"offsets": [
[
0,
156
]
]
}
]
| [
{
"id": "split_0_train_6248_entity",
"type": "progene_text",
"text": [
"ATPase"
],
"offsets": [
[
116,
122
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3959 | split_0_train_3959 | [
{
"id": "split_0_train_3959_passage",
"type": "progene_text",
"text": [
"Although overexpression of the mutant form of either Prp16p , Prp22p , or Prp44p was lethal , only expression of the mutant Prp44p resulted in accumulation of the U4 / U6 helix ."
],
"offsets": [
[
0,
178
]
]
}
]
| [
{
"id": "split_0_train_6249_entity",
"type": "progene_text",
"text": [
"Prp16p"
],
"offsets": [
[
53,
59
]
],
"normalized": []
},
{
"id": "split_0_train_6250_entity",
"type": "progene_text",
"text": [
"Prp22p"
],
"offsets": [
[
62,
68
]
],
"normalized": []
},
{
"id": "split_0_train_6251_entity",
"type": "progene_text",
"text": [
"Prp44p"
],
"offsets": [
[
74,
80
]
],
"normalized": []
},
{
"id": "split_0_train_6252_entity",
"type": "progene_text",
"text": [
"Prp44p"
],
"offsets": [
[
124,
130
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3960 | split_0_train_3960 | [
{
"id": "split_0_train_3960_passage",
"type": "progene_text",
"text": [
"Our results , when combined with previously published in vitro results , support a direct role for Prp44p in unwinding of the U4 / U6 helix ."
],
"offsets": [
[
0,
141
]
]
}
]
| [
{
"id": "split_0_train_6253_entity",
"type": "progene_text",
"text": [
"Prp44p"
],
"offsets": [
[
99,
105
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3961 | split_0_train_3961 | [
{
"id": "split_0_train_3961_passage",
"type": "progene_text",
"text": [
"Cardiopulmonary and CD4 cell changes in response to exercise training in early symptomatic HIV infection ."
],
"offsets": [
[
0,
106
]
]
}
]
| [
{
"id": "split_0_train_6254_entity",
"type": "progene_text",
"text": [
"CD4"
],
"offsets": [
[
20,
23
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3962 | split_0_train_3962 | [
{
"id": "split_0_train_3962_passage",
"type": "progene_text",
"text": [
"PURPOSE :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3963 | split_0_train_3963 | [
{
"id": "split_0_train_3963_passage",
"type": "progene_text",
"text": [
"The purposes of the present study were to assess the effects of a 12 - wk laboratory based aerobic exercise program on cardiopulmonary function , CD4 cell count , and physician - assessed health status among symptomatic pre - AIDS HIV - infected individuals ( N = 28 ) and to assess the degree to which ill health was associated with exercise relapse ."
],
"offsets": [
[
0,
352
]
]
}
]
| [
{
"id": "split_0_train_6255_entity",
"type": "progene_text",
"text": [
"CD4"
],
"offsets": [
[
146,
149
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3964 | split_0_train_3964 | [
{
"id": "split_0_train_3964_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3965 | split_0_train_3965 | [
{
"id": "split_0_train_3965_passage",
"type": "progene_text",
"text": [
"Responses to graded exercise test , physician - assessed health status , and CD4 cell counts were determined at baseline and 12 - wk follow - up for participants randomly assigned to exercise or control conditions , and reasons for exercise noncompliance were recorded ."
],
"offsets": [
[
0,
270
]
]
}
]
| [
{
"id": "split_0_train_6256_entity",
"type": "progene_text",
"text": [
"CD4"
],
"offsets": [
[
77,
80
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3966 | split_0_train_3966 | [
{
"id": "split_0_train_3966_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3967 | split_0_train_3967 | [
{
"id": "split_0_train_3967_passage",
"type": "progene_text",
"text": [
"Approximately 61 % of exercise - assigned participants complied ( > 50 % attendance ) with the exercise program , and analyses of exercise relapse data indicated that obesity and smoking status , but not exercise - associated illness , differentiated compliant from noncompliant exercisers ."
],
"offsets": [
[
0,
291
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3968 | split_0_train_3968 | [
{
"id": "split_0_train_3968_passage",
"type": "progene_text",
"text": [
"Compliant exercisers significantly improved peak oxygen consumption ( VO2peak ; 12 % ) , oxygen pulse ( O2pulse ; 13 % ) , tidal volume ( TV ; 8 % ) , ventilation ( VE ; 17 % ) , and leg power ( 25 % ) to a greater degree than control participants and noncompliant exercisers ( all P < 0.05 ) ."
],
"offsets": [
[
0,
294
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3969 | split_0_train_3969 | [
{
"id": "split_0_train_3969_passage",
"type": "progene_text",
"text": [
"Although no group differences in health status were found , a significant interaction effect indicated that noncompliant exercisers ' CD4 cells declined ( 18 % ) significantly , whereas compliant exercisers ' cell counts significantly increased ( 13 % ; P < 0.05 ) ."
],
"offsets": [
[
0,
266
]
]
}
]
| [
{
"id": "split_0_train_6257_entity",
"type": "progene_text",
"text": [
"CD4"
],
"offsets": [
[
134,
137
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3970 | split_0_train_3970 | [
{
"id": "split_0_train_3970_passage",
"type": "progene_text",
"text": [
"CONCLUSION :"
],
"offsets": [
[
0,
12
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3971 | split_0_train_3971 | [
{
"id": "split_0_train_3971_passage",
"type": "progene_text",
"text": [
"We conclude that although aerobic exercise can improve cardiopulmonary functioning in symptomatic HIV - infected individuals with minimal health risks , attention to factors associated with exercise adherence is warranted ."
],
"offsets": [
[
0,
223
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3972 | split_0_train_3972 | [
{
"id": "split_0_train_3972_passage",
"type": "progene_text",
"text": [
"Characterization of the genomic structure of the murine Spam1 gene and its promoter : evidence for transcriptional regulation by a cAMP - responsive element ."
],
"offsets": [
[
0,
158
]
]
}
]
| [
{
"id": "split_0_train_6258_entity",
"type": "progene_text",
"text": [
"Spam1"
],
"offsets": [
[
56,
61
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3973 | split_0_train_3973 | [
{
"id": "split_0_train_3973_passage",
"type": "progene_text",
"text": [
"The Sperm Adhesion Molecule 1 ( SPAM1 ) , also known as PH-20 , is a sperm membrane - bound protein that has been shown to have bifunctional roles in fertilization ."
],
"offsets": [
[
0,
165
]
]
}
]
| [
{
"id": "split_0_train_6259_entity",
"type": "progene_text",
"text": [
"Sperm Adhesion Molecule 1"
],
"offsets": [
[
4,
29
]
],
"normalized": []
},
{
"id": "split_0_train_6260_entity",
"type": "progene_text",
"text": [
"SPAM1"
],
"offsets": [
[
32,
37
]
],
"normalized": []
},
{
"id": "split_0_train_6261_entity",
"type": "progene_text",
"text": [
"PH-20"
],
"offsets": [
[
56,
61
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3974 | split_0_train_3974 | [
{
"id": "split_0_train_3974_passage",
"type": "progene_text",
"text": [
"It is encoded by a gene that is widely conserved in mammalian species , underscoring its importance in the fertilization process ."
],
"offsets": [
[
0,
130
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3975 | split_0_train_3975 | [
{
"id": "split_0_train_3975_passage",
"type": "progene_text",
"text": [
"Here we determined the genomic structure of the murine homologue , Spam1 , using PCR analysis , and studied its transcriptional regulation ."
],
"offsets": [
[
0,
140
]
]
}
]
| [
{
"id": "split_0_train_6262_entity",
"type": "progene_text",
"text": [
"Spam1"
],
"offsets": [
[
67,
72
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3976 | split_0_train_3976 | [
{
"id": "split_0_train_3976_passage",
"type": "progene_text",
"text": [
"The gene covers approximately 10.5 kb of genomic DNA , is encoded by four exons , and the splice site consensus sequence is maintained in all intron - exon junctions , similar to that reported for the human homologue ."
],
"offsets": [
[
0,
218
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3977 | split_0_train_3977 | [
{
"id": "split_0_train_3977_passage",
"type": "progene_text",
"text": [
"With primer extension analysis , two transcription initiation sites were detected ."
],
"offsets": [
[
0,
83
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3978 | split_0_train_3978 | [
{
"id": "split_0_train_3978_passage",
"type": "progene_text",
"text": [
"One was assigned to the residue C and the other ( a minor site ) to the residue G , at positions 1 and - 56 , respectively ."
],
"offsets": [
[
0,
124
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3979 | split_0_train_3979 | [
{
"id": "split_0_train_3979_passage",
"type": "progene_text",
"text": [
"These are at 313 and 369 nucleotides upstream of the translation initiation codon , ATG ."
],
"offsets": [
[
0,
89
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3980 | split_0_train_3980 | [
{
"id": "split_0_train_3980_passage",
"type": "progene_text",
"text": [
"In about 770 bp upstream region of Spam1 that has been cloned and sequenced , multiple transcription factor binding sites including a CRE ( cAMP - responsive element ) were found ."
],
"offsets": [
[
0,
180
]
]
}
]
| [
{
"id": "split_0_train_6263_entity",
"type": "progene_text",
"text": [
"Spam1"
],
"offsets": [
[
35,
40
]
],
"normalized": []
},
{
"id": "split_0_train_6264_entity",
"type": "progene_text",
"text": [
"transcription factor"
],
"offsets": [
[
87,
107
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3981 | split_0_train_3981 | [
{
"id": "split_0_train_3981_passage",
"type": "progene_text",
"text": [
"We specifically studied the function of the eight nucleotide CRE sequence ( TGATGTCA ) at - 57 ( or - 62 depending on the strain of mice ) of the promoter region ."
],
"offsets": [
[
0,
163
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3982 | split_0_train_3982 | [
{
"id": "split_0_train_3982_passage",
"type": "progene_text",
"text": [
"It can bind to the transcription factor CREM ( cAMP - responsive element modulator ) in gel mobility shift assays using mouse testis nuclear extract , and the binding can be inhibited by a 28 bp oligonucleotide containing the CRE sequence ."
],
"offsets": [
[
0,
240
]
]
}
]
| [
{
"id": "split_0_train_6265_entity",
"type": "progene_text",
"text": [
"transcription factor"
],
"offsets": [
[
19,
39
]
],
"normalized": []
},
{
"id": "split_0_train_6266_entity",
"type": "progene_text",
"text": [
"CREM"
],
"offsets": [
[
40,
44
]
],
"normalized": []
},
{
"id": "split_0_train_6267_entity",
"type": "progene_text",
"text": [
"cAMP - responsive element modulator"
],
"offsets": [
[
47,
82
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3983 | split_0_train_3983 | [
{
"id": "split_0_train_3983_passage",
"type": "progene_text",
"text": [
"Similar binding and inhibition assays using rat nuclear extract suggest the existence of a rat CRE sequence and the involvement of CREM in rat Spam1 expression ."
],
"offsets": [
[
0,
161
]
]
}
]
| [
{
"id": "split_0_train_6268_entity",
"type": "progene_text",
"text": [
"CREM"
],
"offsets": [
[
131,
135
]
],
"normalized": []
},
{
"id": "split_0_train_6269_entity",
"type": "progene_text",
"text": [
"Spam1"
],
"offsets": [
[
143,
148
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3984 | split_0_train_3984 | [
{
"id": "split_0_train_3984_passage",
"type": "progene_text",
"text": [
"In vitro transcription assays suggest that CRE is necessary for the transcriptional activity of the murine promoter , and Northern analysis shows that Spam1 transcripts are absent in CREM - knockout mice ."
],
"offsets": [
[
0,
205
]
]
}
]
| [
{
"id": "split_0_train_6270_entity",
"type": "progene_text",
"text": [
"Spam1"
],
"offsets": [
[
151,
156
]
],
"normalized": []
},
{
"id": "split_0_train_6271_entity",
"type": "progene_text",
"text": [
"CREM"
],
"offsets": [
[
183,
187
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3985 | split_0_train_3985 | [
{
"id": "split_0_train_3985_passage",
"type": "progene_text",
"text": [
"The results strongly suggest that the murine Spam1 expression is under the control of CREM , and that this transcriptional regulator for Spam1 might be conserved in other mammals , at least in the rat ."
],
"offsets": [
[
0,
202
]
]
}
]
| [
{
"id": "split_0_train_6272_entity",
"type": "progene_text",
"text": [
"Spam1"
],
"offsets": [
[
45,
50
]
],
"normalized": []
},
{
"id": "split_0_train_6273_entity",
"type": "progene_text",
"text": [
"CREM"
],
"offsets": [
[
86,
90
]
],
"normalized": []
},
{
"id": "split_0_train_6274_entity",
"type": "progene_text",
"text": [
"Spam1"
],
"offsets": [
[
137,
142
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3986 | split_0_train_3986 | [
{
"id": "split_0_train_3986_passage",
"type": "progene_text",
"text": [
"Substitution of the insulin receptor transmembrane domain with that of glycophorin A inhibits insulin action ."
],
"offsets": [
[
0,
110
]
]
}
]
| [
{
"id": "split_0_train_6275_entity",
"type": "progene_text",
"text": [
"insulin receptor"
],
"offsets": [
[
20,
36
]
],
"normalized": []
},
{
"id": "split_0_train_6276_entity",
"type": "progene_text",
"text": [
"glycophorin A"
],
"offsets": [
[
71,
84
]
],
"normalized": []
},
{
"id": "split_0_train_6277_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
94,
101
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3987 | split_0_train_3987 | [
{
"id": "split_0_train_3987_passage",
"type": "progene_text",
"text": [
"To study the role of transmembrane ( TM ) domains interactions in the activation of the insulin receptor , we have replaced the insulin receptor TM domain with that of glycophorin A ( GpA ) , an erythrocyte protein that spontaneously forms detergent - resistant dimers through TM - TM interactions ."
],
"offsets": [
[
0,
299
]
]
}
]
| [
{
"id": "split_0_train_6278_entity",
"type": "progene_text",
"text": [
"insulin receptor"
],
"offsets": [
[
88,
104
]
],
"normalized": []
},
{
"id": "split_0_train_6279_entity",
"type": "progene_text",
"text": [
"insulin receptor"
],
"offsets": [
[
128,
144
]
],
"normalized": []
},
{
"id": "split_0_train_6280_entity",
"type": "progene_text",
"text": [
"glycophorin A"
],
"offsets": [
[
168,
181
]
],
"normalized": []
},
{
"id": "split_0_train_6281_entity",
"type": "progene_text",
"text": [
"GpA"
],
"offsets": [
[
184,
187
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3988 | split_0_train_3988 | [
{
"id": "split_0_train_3988_passage",
"type": "progene_text",
"text": [
"Insulin receptor cDNA sequences with the TM domain replaced by that of GpA were constructed and stably transfected in CHO cells ."
],
"offsets": [
[
0,
129
]
]
}
]
| [
{
"id": "split_0_train_6282_entity",
"type": "progene_text",
"text": [
"Insulin receptor"
],
"offsets": [
[
0,
16
]
],
"normalized": []
},
{
"id": "split_0_train_6283_entity",
"type": "progene_text",
"text": [
"GpA"
],
"offsets": [
[
71,
74
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3989 | split_0_train_3989 | [
{
"id": "split_0_train_3989_passage",
"type": "progene_text",
"text": [
"Insulin binding to cells and solubilized receptors was not modified ."
],
"offsets": [
[
0,
69
]
]
}
]
| [
{
"id": "split_0_train_6284_entity",
"type": "progene_text",
"text": [
"Insulin"
],
"offsets": [
[
0,
7
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3990 | split_0_train_3990 | [
{
"id": "split_0_train_3990_passage",
"type": "progene_text",
"text": [
"Electrophoresis after partial reduction of disulfide bonds revealed an altered structure for the soluble chimeric receptors , seen as an altered mobility apparently due to increased interactions between the beta subunits of the receptor ."
],
"offsets": [
[
0,
238
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3991 | split_0_train_3991 | [
{
"id": "split_0_train_3991_passage",
"type": "progene_text",
"text": [
"Insulin signaling was markedly decreased for cells transfected with chimeric receptors compared with cells transfected with normal receptors ."
],
"offsets": [
[
0,
142
]
]
}
]
| [
{
"id": "split_0_train_6285_entity",
"type": "progene_text",
"text": [
"Insulin"
],
"offsets": [
[
0,
7
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3992 | split_0_train_3992 | [
{
"id": "split_0_train_3992_passage",
"type": "progene_text",
"text": [
"A decrease in insulin - induced receptor kinase activity was observed for solubilized chimeric receptors ."
],
"offsets": [
[
0,
106
]
]
}
]
| [
{
"id": "split_0_train_6286_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
14,
21
]
],
"normalized": []
},
{
"id": "split_0_train_6287_entity",
"type": "progene_text",
"text": [
"receptor kinase"
],
"offsets": [
[
32,
47
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3993 | split_0_train_3993 | [
{
"id": "split_0_train_3993_passage",
"type": "progene_text",
"text": [
"In conclusion , substitution by the native GpA TM domain of the insulin receptor results in structurally modified chimeric receptors that are unable to transmit the insulin signal properly ."
],
"offsets": [
[
0,
190
]
]
}
]
| [
{
"id": "split_0_train_6288_entity",
"type": "progene_text",
"text": [
"GpA"
],
"offsets": [
[
43,
46
]
],
"normalized": []
},
{
"id": "split_0_train_6289_entity",
"type": "progene_text",
"text": [
"insulin receptor"
],
"offsets": [
[
64,
80
]
],
"normalized": []
},
{
"id": "split_0_train_6290_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
165,
172
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3994 | split_0_train_3994 | [
{
"id": "split_0_train_3994_passage",
"type": "progene_text",
"text": [
"It is hypothesized that this substitution may impose structural constraints that prevent the proper changes in conformation necessary for activation of the receptor kinase ."
],
"offsets": [
[
0,
173
]
]
}
]
| [
{
"id": "split_0_train_6291_entity",
"type": "progene_text",
"text": [
"receptor kinase"
],
"offsets": [
[
156,
171
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3995 | split_0_train_3995 | [
{
"id": "split_0_train_3995_passage",
"type": "progene_text",
"text": [
"Other mutants modifying the structure or the membrane orientation of the glycophorin A TM domain are required to better understand these constraints ."
],
"offsets": [
[
0,
150
]
]
}
]
| [
{
"id": "split_0_train_6292_entity",
"type": "progene_text",
"text": [
"glycophorin A"
],
"offsets": [
[
73,
86
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3996 | split_0_train_3996 | [
{
"id": "split_0_train_3996_passage",
"type": "progene_text",
"text": [
"Signal - dependent DNA binding and functional domains of the quorum - sensing activator TraR as identified by repressor activity ."
],
"offsets": [
[
0,
130
]
]
}
]
| [
{
"id": "split_0_train_6293_entity",
"type": "progene_text",
"text": [
"TraR"
],
"offsets": [
[
88,
92
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3997 | split_0_train_3997 | [
{
"id": "split_0_train_3997_passage",
"type": "progene_text",
"text": [
"TraR , a member of the LuxR family of quorum - sensing transcription factors , is responsible for the population density - dependent regulation of Ti plasmid conjugal transfer ."
],
"offsets": [
[
0,
177
]
]
}
]
| [
{
"id": "split_0_train_6294_entity",
"type": "progene_text",
"text": [
"TraR"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_6295_entity",
"type": "progene_text",
"text": [
"LuxR family"
],
"offsets": [
[
23,
34
]
],
"normalized": []
},
{
"id": "split_0_train_6296_entity",
"type": "progene_text",
"text": [
"transcription factors"
],
"offsets": [
[
55,
76
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3998 | split_0_train_3998 | [
{
"id": "split_0_train_3998_passage",
"type": "progene_text",
"text": [
"The protein requires as coinducer an acyl - homoserine lactone signal molecule called AAI ( Agrobacterium autoinducer ) that is produced by the bacteria themselves ."
],
"offsets": [
[
0,
165
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3999 | split_0_train_3999 | [
{
"id": "split_0_train_3999_passage",
"type": "progene_text",
"text": [
"TraR only activates its target genes , making it difficult to determine whether interaction with AAI is required for binding DNA or for initiating transcription ."
],
"offsets": [
[
0,
162
]
]
}
]
| [
{
"id": "split_0_train_6297_entity",
"type": "progene_text",
"text": [
"TraR"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
]
| []
| []
| []
|
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