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split_0_train_3700 | split_0_train_3700 | [
{
"id": "split_0_train_3700_passage",
"type": "progene_text",
"text": [
"Northern blot analysis indicated that O. novo - ulmi Ld nucleic acid extracts contain more single - stranded ( ss , positive - stranded ) RNA than dsRNA for all three newly described mitoviruses ."
],
"offsets": [
[
0,
196
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3701 | split_0_train_3701 | [
{
"id": "split_0_train_3701_passage",
"type": "progene_text",
"text": [
"O. novo - ulmi RNA-7 , previously believed to be a satellite - like RNA , is shown to be a defective RNA , derived from OnuMV4 - Ld RNA by multiple internal deletions ."
],
"offsets": [
[
0,
168
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3702 | split_0_train_3702 | [
{
"id": "split_0_train_3702_passage",
"type": "progene_text",
"text": [
"OnuMV4 - Ld is therefore the helper virus for the replication of both RNA-7 and another defective RNA , RNA - 10 ."
],
"offsets": [
[
0,
114
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3703 | split_0_train_3703 | [
{
"id": "split_0_train_3703_passage",
"type": "progene_text",
"text": [
"Sequence comparisons indicate that RNA-10 could be derived from RNA-7 , as previously suggested , or derived directly from RNA-4 ."
],
"offsets": [
[
0,
130
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3704 | split_0_train_3704 | [
{
"id": "split_0_train_3704_passage",
"type": "progene_text",
"text": [
"Characterization of NAD : arginine ADP-ribosyltransferases ."
],
"offsets": [
[
0,
60
]
]
}
]
| [
{
"id": "split_0_train_6002_entity",
"type": "progene_text",
"text": [
"NAD : arginine ADP-ribosyltransferases"
],
"offsets": [
[
20,
58
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3705 | split_0_train_3705 | [
{
"id": "split_0_train_3705_passage",
"type": "progene_text",
"text": [
"NAD : arginine mono-ADP-ribosyltransferases catalyze the transfer of ADP-ribose from NAD to the guanidino group of arginine on a target protein ."
],
"offsets": [
[
0,
145
]
]
}
]
| [
{
"id": "split_0_train_6003_entity",
"type": "progene_text",
"text": [
"NAD : arginine mono-ADP-ribosyltransferases"
],
"offsets": [
[
0,
43
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3706 | split_0_train_3706 | [
{
"id": "split_0_train_3706_passage",
"type": "progene_text",
"text": [
"Deduced amino acid sequences of one family ( ART1 ) of mammalian ADP - ribosyltransferases , cloned from muscle and lymphocytes , show hydrophobic amino and carboxyl termini consistent with glycosylphosphatidylinositol ( GPI ) - anchored proteins ."
],
"offsets": [
[
0,
248
]
]
}
]
| [
{
"id": "split_0_train_6004_entity",
"type": "progene_text",
"text": [
"ART1"
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"offsets": [
[
45,
49
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},
{
"id": "split_0_train_6005_entity",
"type": "progene_text",
"text": [
"ADP - ribosyltransferases"
],
"offsets": [
[
65,
90
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3707 | split_0_train_3707 | [
{
"id": "split_0_train_3707_passage",
"type": "progene_text",
"text": [
"The proteins , overexpressed in mammalian cells transfected with the transferase cDNAs , are released from the cell surface with phosphatidylinositol - specific phospholipase C ( PI-PLC ) , and display immunological and biochemical characteristics consistent with a cell surface , GPI-anchored protein ."
],
"offsets": [
[
0,
303
]
]
}
]
| [
{
"id": "split_0_train_6006_entity",
"type": "progene_text",
"text": [
"transferase"
],
"offsets": [
[
69,
80
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],
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},
{
"id": "split_0_train_6007_entity",
"type": "progene_text",
"text": [
"phosphatidylinositol - specific phospholipase C"
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[
129,
176
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],
"normalized": []
},
{
"id": "split_0_train_6008_entity",
"type": "progene_text",
"text": [
"PI-PLC"
],
"offsets": [
[
179,
185
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3708 | split_0_train_3708 | [
{
"id": "split_0_train_3708_passage",
"type": "progene_text",
"text": [
"In contrast , the deduced amino acid sequence of a second family ( ART5 ) of transferases , cloned from murine lymphoma cells and expressed in high abundance in testis , displays a hydrophobic amino terminus , consistent with a signal sequence , but lacks a hydrophobic signal sequence at its carboxyl terminus , suggesting that the protein is destined for export ."
],
"offsets": [
[
0,
365
]
]
}
]
| [
{
"id": "split_0_train_6009_entity",
"type": "progene_text",
"text": [
"ART5"
],
"offsets": [
[
67,
71
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],
"normalized": []
},
{
"id": "split_0_train_6010_entity",
"type": "progene_text",
"text": [
"transferases"
],
"offsets": [
[
77,
89
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3709 | split_0_train_3709 | [
{
"id": "split_0_train_3709_passage",
"type": "progene_text",
"text": [
"Consistent with the surface localization of the GPI - linked transferases , multiple surface substrates have been identified in myotubes and activated lymphocytes , and , notably , include integrin alpha subunits ."
],
"offsets": [
[
0,
214
]
]
}
]
| [
{
"id": "split_0_train_6011_entity",
"type": "progene_text",
"text": [
"transferases"
],
"offsets": [
[
61,
73
]
],
"normalized": []
},
{
"id": "split_0_train_6012_entity",
"type": "progene_text",
"text": [
"integrin alpha"
],
"offsets": [
[
189,
203
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3710 | split_0_train_3710 | [
{
"id": "split_0_train_3710_passage",
"type": "progene_text",
"text": [
"Similar to the bacterial toxin ADP-ribosyltransferases , the mammalian transferases contain the characteristic domains involved in NAD binding and ADP-ribose transfer , including a highly acidic region near the carboxy terminus , which , when disrupted by in vitro mutagenesis , results in a loss of enzymatic activity ."
],
"offsets": [
[
0,
320
]
]
}
]
| [
{
"id": "split_0_train_6013_entity",
"type": "progene_text",
"text": [
"ADP-ribosyltransferases"
],
"offsets": [
[
31,
54
]
],
"normalized": []
},
{
"id": "split_0_train_6014_entity",
"type": "progene_text",
"text": [
"transferases"
],
"offsets": [
[
71,
83
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3711 | split_0_train_3711 | [
{
"id": "split_0_train_3711_passage",
"type": "progene_text",
"text": [
"The carboxyl half of the protein , synthesized as a fusion protein in E. coli , possessed NADase , but not ADP-ribosyltransferase activity ."
],
"offsets": [
[
0,
140
]
]
}
]
| [
{
"id": "split_0_train_6015_entity",
"type": "progene_text",
"text": [
"NADase"
],
"offsets": [
[
90,
96
]
],
"normalized": []
},
{
"id": "split_0_train_6016_entity",
"type": "progene_text",
"text": [
"ADP-ribosyltransferase"
],
"offsets": [
[
107,
129
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3712 | split_0_train_3712 | [
{
"id": "split_0_train_3712_passage",
"type": "progene_text",
"text": [
"These findings are consistent with the existence at the carboxyl terminus of ART1 of a catalytically active domain , capable of hydrolyzing NAD , but not of transferring ADP-ribose to a guanidino acceptor ."
],
"offsets": [
[
0,
206
]
]
}
]
| [
{
"id": "split_0_train_6017_entity",
"type": "progene_text",
"text": [
"ART1"
],
"offsets": [
[
77,
81
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3713 | split_0_train_3713 | [
{
"id": "split_0_train_3713_passage",
"type": "progene_text",
"text": [
"Cardiopulmonary bypass increases coronary IL-8 in diabetic patients without evidence of reperfusion injury ."
],
"offsets": [
[
0,
108
]
]
}
]
| [
{
"id": "split_0_train_6018_entity",
"type": "progene_text",
"text": [
"IL-8"
],
"offsets": [
[
42,
46
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3714 | split_0_train_3714 | [
{
"id": "split_0_train_3714_passage",
"type": "progene_text",
"text": [
"BACKGROUND :"
],
"offsets": [
[
0,
12
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3715 | split_0_train_3715 | [
{
"id": "split_0_train_3715_passage",
"type": "progene_text",
"text": [
"Endothelin-1 ( ET-1 ) has been shown to be a potent agonist for monocyte production of the neutrophil chemotactic cytokine interleukin-8 ( IL-8 ) ."
],
"offsets": [
[
0,
147
]
]
}
]
| [
{
"id": "split_0_train_6019_entity",
"type": "progene_text",
"text": [
"Endothelin-1"
],
"offsets": [
[
0,
12
]
],
"normalized": []
},
{
"id": "split_0_train_6020_entity",
"type": "progene_text",
"text": [
"ET-1"
],
"offsets": [
[
15,
19
]
],
"normalized": []
},
{
"id": "split_0_train_6021_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
114,
122
]
],
"normalized": []
},
{
"id": "split_0_train_6022_entity",
"type": "progene_text",
"text": [
"interleukin-8"
],
"offsets": [
[
123,
136
]
],
"normalized": []
},
{
"id": "split_0_train_6023_entity",
"type": "progene_text",
"text": [
"IL-8"
],
"offsets": [
[
139,
143
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3716 | split_0_train_3716 | [
{
"id": "split_0_train_3716_passage",
"type": "progene_text",
"text": [
"We have shown that diabetic patients demonstrate elevated coronary ET-1 after coronary artery bypass grafting ( CABG ) ."
],
"offsets": [
[
0,
120
]
]
}
]
| [
{
"id": "split_0_train_6024_entity",
"type": "progene_text",
"text": [
"ET-1"
],
"offsets": [
[
67,
71
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3717 | split_0_train_3717 | [
{
"id": "split_0_train_3717_passage",
"type": "progene_text",
"text": [
"We hypothesized that these same diabetic patients would manifest elevated coronary IL-8 and conjugated diene concentrations ( an index of reperfusion injury ) ."
],
"offsets": [
[
0,
160
]
]
}
]
| [
{
"id": "split_0_train_6025_entity",
"type": "progene_text",
"text": [
"IL-8"
],
"offsets": [
[
83,
87
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3718 | split_0_train_3718 | [
{
"id": "split_0_train_3718_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3719 | split_0_train_3719 | [
{
"id": "split_0_train_3719_passage",
"type": "progene_text",
"text": [
"Sixteen patients [ 9 nondiabetics and 7 type II diabetics ] underwent nonemergent CABG ."
],
"offsets": [
[
0,
88
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3720 | split_0_train_3720 | [
{
"id": "split_0_train_3720_passage",
"type": "progene_text",
"text": [
"The two groups did not differ significantly in preoperative ejection fraction , number of vessels bypassed , or cross - clamp time ."
],
"offsets": [
[
0,
132
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3721 | split_0_train_3721 | [
{
"id": "split_0_train_3721_passage",
"type": "progene_text",
"text": [
"Coronary sinus samples were obtained prior to cardioplegic arrest ( baseline ) and at 1 and 15 min after reperfusion periods A and B ( A , reperfusion of native coronaries + LIMA ; B , reperfusion of saphenous vein grafts in addition to native coronary system + LIMA ) ."
],
"offsets": [
[
0,
270
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3722 | split_0_train_3722 | [
{
"id": "split_0_train_3722_passage",
"type": "progene_text",
"text": [
"Plasma samples were analyzed for IL-8 ( ELISA ) and conjugated dienes ( spectrophotometry ) ."
],
"offsets": [
[
0,
93
]
]
}
]
| [
{
"id": "split_0_train_6026_entity",
"type": "progene_text",
"text": [
"IL-8"
],
"offsets": [
[
33,
37
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3723 | split_0_train_3723 | [
{
"id": "split_0_train_3723_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3724 | split_0_train_3724 | [
{
"id": "split_0_train_3724_passage",
"type": "progene_text",
"text": [
"Initially after reperfusion , IL-8 in both groups was significantly lower than precardioplegia values ."
],
"offsets": [
[
0,
103
]
]
}
]
| [
{
"id": "split_0_train_6027_entity",
"type": "progene_text",
"text": [
"IL-8"
],
"offsets": [
[
30,
34
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3725 | split_0_train_3725 | [
{
"id": "split_0_train_3725_passage",
"type": "progene_text",
"text": [
"In reperfusion B , only the diabetic group demonstrated a significant increase in IL-8 concentrations at 1 and 15 min compared to nondiabetics ."
],
"offsets": [
[
0,
144
]
]
}
]
| [
{
"id": "split_0_train_6028_entity",
"type": "progene_text",
"text": [
"IL-8"
],
"offsets": [
[
82,
86
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3726 | split_0_train_3726 | [
{
"id": "split_0_train_3726_passage",
"type": "progene_text",
"text": [
"Conjugated diene levels were significantly higher in diabetics at each time point than nondiabetics ."
],
"offsets": [
[
0,
101
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3727 | split_0_train_3727 | [
{
"id": "split_0_train_3727_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3728 | split_0_train_3728 | [
{
"id": "split_0_train_3728_passage",
"type": "progene_text",
"text": [
"This study demonstrates an early decrease in IL-8 in both groups , most likely related to depressed production secondary to hypothermia ."
],
"offsets": [
[
0,
137
]
]
}
]
| [
{
"id": "split_0_train_6029_entity",
"type": "progene_text",
"text": [
"IL-8"
],
"offsets": [
[
45,
49
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3729 | split_0_train_3729 | [
{
"id": "split_0_train_3729_passage",
"type": "progene_text",
"text": [
"The subsequent elevation in IL-8 only in the diabetic group was seen without concomitant conjugated diene elevation ."
],
"offsets": [
[
0,
117
]
]
}
]
| [
{
"id": "split_0_train_6030_entity",
"type": "progene_text",
"text": [
"IL-8"
],
"offsets": [
[
28,
32
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3730 | split_0_train_3730 | [
{
"id": "split_0_train_3730_passage",
"type": "progene_text",
"text": [
"While no evidence of reperfusion injury was demonstrated in this time frame , the elevation of IL-8 in diabetics after CABG may contribute to later infiltration and associated oxidative damage ."
],
"offsets": [
[
0,
194
]
]
}
]
| [
{
"id": "split_0_train_6031_entity",
"type": "progene_text",
"text": [
"IL-8"
],
"offsets": [
[
95,
99
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3731 | split_0_train_3731 | [
{
"id": "split_0_train_3731_passage",
"type": "progene_text",
"text": [
"A phase I study of paclitaxel and epirubicin , without and with filgrastim , for the treatment of platinum - resistant advanced ovarian cancer ."
],
"offsets": [
[
0,
144
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3732 | split_0_train_3732 | [
{
"id": "split_0_train_3732_passage",
"type": "progene_text",
"text": [
"The aim of the study was to determine the maximum tolerated dose ( MTD ) of epirubicin combined with a fixed dose of paclitaxel , without and with support of filgrastim , in patients with platinum resistant or refractory ovarian cancer ."
],
"offsets": [
[
0,
237
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3733 | split_0_train_3733 | [
{
"id": "split_0_train_3733_passage",
"type": "progene_text",
"text": [
"Paclitaxel ( 150 mg / m2 ) and epirubicin ( starting dose 90 mg / m2 , 15 mg / m2 escalation per level ) were given on day 1 , every 28 days for 4 - 6 cycles ."
],
"offsets": [
[
0,
159
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3734 | split_0_train_3734 | [
{
"id": "split_0_train_3734_passage",
"type": "progene_text",
"text": [
"Filgrastim ( F ) ( 5 microg / kg / die ) was given in case of grade 4 leukopenia ( levels without support ) or from day 4 up to leukocyte count > 10,000 / mm3 after nadir ( levels with support ) ."
],
"offsets": [
[
0,
196
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3735 | split_0_train_3735 | [
{
"id": "split_0_train_3735_passage",
"type": "progene_text",
"text": [
"Cohorts of 3 patients were enrolled at each level and further 3 patients were planned if 1 or 2 unacceptable toxic events ( UTE ) were registered ."
],
"offsets": [
[
0,
147
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3736 | split_0_train_3736 | [
{
"id": "split_0_train_3736_passage",
"type": "progene_text",
"text": [
"MTD was determined first without and then with filgrastim ."
],
"offsets": [
[
0,
59
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3737 | split_0_train_3737 | [
{
"id": "split_0_train_3737_passage",
"type": "progene_text",
"text": [
"Four levels were studied ( 90 , 90 + F , 105 + F , 120 + F ) with 4 , 6 , 5 and 4 patients enrolled , respectively ."
],
"offsets": [
[
0,
116
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3738 | split_0_train_3738 | [
{
"id": "split_0_train_3738_passage",
"type": "progene_text",
"text": [
"UTE ( grade 4 neutropenia ) were observed in 3 patients at level 1 ."
],
"offsets": [
[
0,
68
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3739 | split_0_train_3739 | [
{
"id": "split_0_train_3739_passage",
"type": "progene_text",
"text": [
"Thus , 90 mg / m2 was the MTD for epirubicin without filgrastim ."
],
"offsets": [
[
0,
65
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3740 | split_0_train_3740 | [
{
"id": "split_0_train_3740_passage",
"type": "progene_text",
"text": [
"MTD of epirubicin with filgrastim was not reached at 120 mg / m2 ."
],
"offsets": [
[
0,
66
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3741 | split_0_train_3741 | [
{
"id": "split_0_train_3741_passage",
"type": "progene_text",
"text": [
"Hematological toxicity was mild ."
],
"offsets": [
[
0,
33
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3742 | split_0_train_3742 | [
{
"id": "split_0_train_3742_passage",
"type": "progene_text",
"text": [
"Grade 3 mucositis was reported in 1 patient ."
],
"offsets": [
[
0,
45
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3743 | split_0_train_3743 | [
{
"id": "split_0_train_3743_passage",
"type": "progene_text",
"text": [
"Among the 14 patients with measurable or evaluable disease , 3 objective responses were observed ( 1 complete and 2 partial ) for an overall response rate of 21.4 % ."
],
"offsets": [
[
0,
166
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3744 | split_0_train_3744 | [
{
"id": "split_0_train_3744_passage",
"type": "progene_text",
"text": [
"The combination of paclitaxel 150 mg / m2 and epirubicin at 120 mg / m2 with filgrastim is a feasible therapy ."
],
"offsets": [
[
0,
111
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3745 | split_0_train_3745 | [
{
"id": "split_0_train_3745_passage",
"type": "progene_text",
"text": [
"Grade 4 leukopenia is the dose limiting toxicity using epirubicin at 90 mg / m2 without filgrastim ."
],
"offsets": [
[
0,
100
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3746 | split_0_train_3746 | [
{
"id": "split_0_train_3746_passage",
"type": "progene_text",
"text": [
"[ The susceptibility of Anopheles pseudopunctipennis larvae to parasitism by the nematode Romanomermis iyengari ( Nematoda : Mermithidae ) , the state of Oaxaca , Mexico ] Mosquito larvae of the species Anopheles pseudopunctipennis Theobald 1901 were studied under laboratory and field conditions to evaluate the level of susceptibility to the parasitism of nematode Romanomermis iyengari Welch 1964 ."
],
"offsets": [
[
0,
401
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3747 | split_0_train_3747 | [
{
"id": "split_0_train_3747_passage",
"type": "progene_text",
"text": [
"Doses of 5 : 1 and 10 : 1 and development stage II larvae collected in natural reservoirs were used for the laboratory assays ."
],
"offsets": [
[
0,
127
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3748 | split_0_train_3748 | [
{
"id": "split_0_train_3748_passage",
"type": "progene_text",
"text": [
"A dose of 1,000 preparasitic agents / m2 was applied to field trials ."
],
"offsets": [
[
0,
70
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3749 | split_0_train_3749 | [
{
"id": "split_0_train_3749_passage",
"type": "progene_text",
"text": [
"The results of the lab and field tests yielded high levels of infestation in larvae with values ranging from 90 to 100 % and from 85 to 95 % , respectively ."
],
"offsets": [
[
0,
157
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3750 | split_0_train_3750 | [
{
"id": "split_0_train_3750_passage",
"type": "progene_text",
"text": [
"A marked reduction of the larval densities was observed in the 5 treated reservoirs seven days later , which showed an elevated susceptibility of the anopheline species to mermithid parasitism ."
],
"offsets": [
[
0,
194
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3751 | split_0_train_3751 | [
{
"id": "split_0_train_3751_passage",
"type": "progene_text",
"text": [
"Body composition in HIV - infected children : relations with disease progression and survival ."
],
"offsets": [
[
0,
95
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3752 | split_0_train_3752 | [
{
"id": "split_0_train_3752_passage",
"type": "progene_text",
"text": [
"BACKGROUND :"
],
"offsets": [
[
0,
12
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3753 | split_0_train_3753 | [
{
"id": "split_0_train_3753_passage",
"type": "progene_text",
"text": [
"Malnutrition is common in HIV - infected children , but the body compartment that is most affected has been ill defined ."
],
"offsets": [
[
0,
121
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3754 | split_0_train_3754 | [
{
"id": "split_0_train_3754_passage",
"type": "progene_text",
"text": [
"OBJECTIVES :"
],
"offsets": [
[
0,
12
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3755 | split_0_train_3755 | [
{
"id": "split_0_train_3755_passage",
"type": "progene_text",
"text": [
"Our objectives were to 1 ) compare the fat - free mass ( FFM ) of children with HIV infection with that of control children , 2 ) assess the contribution of FFM to body weight in HIV - infected children compared with that of control children , and 3 ) study the relations between body weight , FFM , and mortality ."
],
"offsets": [
[
0,
315
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3756 | split_0_train_3756 | [
{
"id": "split_0_train_3756_passage",
"type": "progene_text",
"text": [
"DESIGN :"
],
"offsets": [
[
0,
8
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3757 | split_0_train_3757 | [
{
"id": "split_0_train_3757_passage",
"type": "progene_text",
"text": [
"A cross - sectional study was performed in 86 HIV - infected and 113 uninfected children ( mean ages : 6.9 and 7.7 y , respectively ) ."
],
"offsets": [
[
0,
135
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3758 | split_0_train_3758 | [
{
"id": "split_0_train_3758_passage",
"type": "progene_text",
"text": [
"FFM was estimated from single - frequency bioelectrical impedance analysis by using 3 different published equations ; a further estimate was obtained from triceps - skinfold - thickness measurements ."
],
"offsets": [
[
0,
200
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3759 | split_0_train_3759 | [
{
"id": "split_0_train_3759_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3760 | split_0_train_3760 | [
{
"id": "split_0_train_3760_passage",
"type": "progene_text",
"text": [
"All 4 estimates of body composition showed that FFM in HIV - infected children was significantly less than in control children of similar age ."
],
"offsets": [
[
0,
143
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3761 | split_0_train_3761 | [
{
"id": "split_0_train_3761_passage",
"type": "progene_text",
"text": [
"However , FFM as a percentage of body weight was not significantly different between groups ."
],
"offsets": [
[
0,
93
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3762 | split_0_train_3762 | [
{
"id": "split_0_train_3762_passage",
"type": "progene_text",
"text": [
"In the whole group of infected children , an age - specific z score < -2 for weight and for FFM was significantly associated with an increased risk of death [ relative risk ( 95 % CI ) = 11.4 ( 3.1 , 41.0 ) and 5.1 ( 1.5 , 18.2 ) , respectively ] ; when only children with more severe disease were considered , only z score for weight was significantly associated with an increased risk [ 4.6 ( 1.4 , 14.9 ) ] ."
],
"offsets": [
[
0,
411
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3763 | split_0_train_3763 | [
{
"id": "split_0_train_3763_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3764 | split_0_train_3764 | [
{
"id": "split_0_train_3764_passage",
"type": "progene_text",
"text": [
"These findings suggest that no preferential catabolism of FFM occurs in HIV - infected children and that body weight for age is a better prognostic indicator than is FFM estimated by bioelectrical impedance analysis ."
],
"offsets": [
[
0,
217
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3765 | split_0_train_3765 | [
{
"id": "split_0_train_3765_passage",
"type": "progene_text",
"text": [
"Identification of a functional transcriptional factor AP-1 site in the sheep interferon tau gene that mediates a response to PMA in JEG3 cells ."
],
"offsets": [
[
0,
144
]
]
}
]
| [
{
"id": "split_0_train_6032_entity",
"type": "progene_text",
"text": [
"transcriptional factor"
],
"offsets": [
[
31,
53
]
],
"normalized": []
},
{
"id": "split_0_train_6033_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
54,
58
]
],
"normalized": []
},
{
"id": "split_0_train_6034_entity",
"type": "progene_text",
"text": [
"interferon tau"
],
"offsets": [
[
77,
91
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3766 | split_0_train_3766 | [
{
"id": "split_0_train_3766_passage",
"type": "progene_text",
"text": [
"To examine regulatory mechanisms of sheep interferon tau ( oIFNtau ) gene expression , potential enhancer / silencer elements of the oIFNtau gene were examined using a transient transfection system with oIFNtau gene - chloramphenicol acetyltransferase ( oIFNtau - CAT ) reporter constructs in human choriocarcinoma cells , JEG3 ."
],
"offsets": [
[
0,
329
]
]
}
]
| [
{
"id": "split_0_train_6035_entity",
"type": "progene_text",
"text": [
"interferon tau"
],
"offsets": [
[
42,
56
]
],
"normalized": []
},
{
"id": "split_0_train_6036_entity",
"type": "progene_text",
"text": [
"oIFNtau"
],
"offsets": [
[
59,
66
]
],
"normalized": []
},
{
"id": "split_0_train_6037_entity",
"type": "progene_text",
"text": [
"oIFNtau"
],
"offsets": [
[
133,
140
]
],
"normalized": []
},
{
"id": "split_0_train_6038_entity",
"type": "progene_text",
"text": [
"oIFNtau"
],
"offsets": [
[
203,
210
]
],
"normalized": []
},
{
"id": "split_0_train_6039_entity",
"type": "progene_text",
"text": [
"chloramphenicol acetyltransferase"
],
"offsets": [
[
218,
251
]
],
"normalized": []
},
{
"id": "split_0_train_6040_entity",
"type": "progene_text",
"text": [
"oIFNtau"
],
"offsets": [
[
254,
261
]
],
"normalized": []
},
{
"id": "split_0_train_6041_entity",
"type": "progene_text",
"text": [
"CAT"
],
"offsets": [
[
264,
267
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3767 | split_0_train_3767 | [
{
"id": "split_0_train_3767_passage",
"type": "progene_text",
"text": [
"Experiments with 5'-deletion constructs revealed that the upstream regions from bases - 654 to - 607 and from bases - 606 to - 555 were essential for oIFNtau gene expression ."
],
"offsets": [
[
0,
175
]
]
}
]
| [
{
"id": "split_0_train_6042_entity",
"type": "progene_text",
"text": [
"oIFNtau"
],
"offsets": [
[
150,
157
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3768 | split_0_train_3768 | [
{
"id": "split_0_train_3768_passage",
"type": "progene_text",
"text": [
"In a heterologous transcriptional system in which the upstream regions of oIFNtau were inserted in front of simian virus 40 ( SV40 ) promoter , the regions between bases - 654 and - 555 were determined as being the enhancer region required for oIFNtau - SV40 - CAT transactivation ."
],
"offsets": [
[
0,
282
]
]
}
]
| [
{
"id": "split_0_train_6043_entity",
"type": "progene_text",
"text": [
"oIFNtau"
],
"offsets": [
[
74,
81
]
],
"normalized": []
},
{
"id": "split_0_train_6044_entity",
"type": "progene_text",
"text": [
"oIFNtau"
],
"offsets": [
[
244,
251
]
],
"normalized": []
},
{
"id": "split_0_train_6045_entity",
"type": "progene_text",
"text": [
"CAT"
],
"offsets": [
[
261,
264
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3769 | split_0_train_3769 | [
{
"id": "split_0_train_3769_passage",
"type": "progene_text",
"text": [
"A subsequent study with the oIFNtau - CAT constructs lacking the upstream region between bases - 542 and - 124 revealed that , in addition to the further upstream region between bases - 1000 and - 654 , the sequences from bases - 543 to - 452 seemed to act as silencer regions ."
],
"offsets": [
[
0,
278
]
]
}
]
| [
{
"id": "split_0_train_6046_entity",
"type": "progene_text",
"text": [
"oIFNtau"
],
"offsets": [
[
28,
35
]
],
"normalized": []
},
{
"id": "split_0_train_6047_entity",
"type": "progene_text",
"text": [
"CAT"
],
"offsets": [
[
38,
41
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3770 | split_0_train_3770 | [
{
"id": "split_0_train_3770_passage",
"type": "progene_text",
"text": [
"The oIFNtau - CAT constructs with site - specific mutagenesis revealed that multiple enhancer elements existed between bases - 654 and - 555 of the oIFNtau gene ."
],
"offsets": [
[
0,
162
]
]
}
]
| [
{
"id": "split_0_train_6048_entity",
"type": "progene_text",
"text": [
"oIFNtau"
],
"offsets": [
[
4,
11
]
],
"normalized": []
},
{
"id": "split_0_train_6049_entity",
"type": "progene_text",
"text": [
"CAT"
],
"offsets": [
[
14,
17
]
],
"normalized": []
},
{
"id": "split_0_train_6050_entity",
"type": "progene_text",
"text": [
"oIFNtau"
],
"offsets": [
[
148,
155
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3771 | split_0_train_3771 | [
{
"id": "split_0_train_3771_passage",
"type": "progene_text",
"text": [
"On the basis of nucleotide sequence analysis , there are numerous sites between bases - 654 and - 555 to which potential transcriptional factors , AP-1 , GATA and GATA - related proteins , could bind ."
],
"offsets": [
[
0,
201
]
]
}
]
| [
{
"id": "split_0_train_6051_entity",
"type": "progene_text",
"text": [
"transcriptional factors"
],
"offsets": [
[
121,
144
]
],
"normalized": []
},
{
"id": "split_0_train_6052_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
147,
151
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3772 | split_0_train_3772 | [
{
"id": "split_0_train_3772_passage",
"type": "progene_text",
"text": [
"Furthermore , gel mobility - shift assays revealed that AP-1 or other nuclear factors could bind to these elements ."
],
"offsets": [
[
0,
116
]
]
}
]
| [
{
"id": "split_0_train_6053_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
56,
60
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3773 | split_0_train_3773 | [
{
"id": "split_0_train_3773_passage",
"type": "progene_text",
"text": [
"In co - transfection studies , the expression of c-Jun plus c-Fos enhanced the transactivation of oIFNtau - CAT but the expression of GATA-1 , GATA-2 or GATA-3 did not ."
],
"offsets": [
[
0,
169
]
]
}
]
| [
{
"id": "split_0_train_6054_entity",
"type": "progene_text",
"text": [
"c-Jun"
],
"offsets": [
[
49,
54
]
],
"normalized": []
},
{
"id": "split_0_train_6055_entity",
"type": "progene_text",
"text": [
"c-Fos"
],
"offsets": [
[
60,
65
]
],
"normalized": []
},
{
"id": "split_0_train_6056_entity",
"type": "progene_text",
"text": [
"oIFNtau"
],
"offsets": [
[
98,
105
]
],
"normalized": []
},
{
"id": "split_0_train_6057_entity",
"type": "progene_text",
"text": [
"CAT"
],
"offsets": [
[
108,
111
]
],
"normalized": []
},
{
"id": "split_0_train_6058_entity",
"type": "progene_text",
"text": [
"GATA-1"
],
"offsets": [
[
134,
140
]
],
"normalized": []
},
{
"id": "split_0_train_6059_entity",
"type": "progene_text",
"text": [
"GATA-2"
],
"offsets": [
[
143,
149
]
],
"normalized": []
},
{
"id": "split_0_train_6060_entity",
"type": "progene_text",
"text": [
"GATA-3"
],
"offsets": [
[
153,
159
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3774 | split_0_train_3774 | [
{
"id": "split_0_train_3774_passage",
"type": "progene_text",
"text": [
"Taken together , these results suggest that the upstream region between bases - 654 and - 555 could be considered as the enhancer region for oIFNtau gene transactivation ."
],
"offsets": [
[
0,
171
]
]
}
]
| [
{
"id": "split_0_train_6061_entity",
"type": "progene_text",
"text": [
"oIFNtau"
],
"offsets": [
[
141,
148
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3775 | split_0_train_3775 | [
{
"id": "split_0_train_3775_passage",
"type": "progene_text",
"text": [
"Ultrasonographic evaluation of tumorous lesions in digital vessels ."
],
"offsets": [
[
0,
68
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3776 | split_0_train_3776 | [
{
"id": "split_0_train_3776_passage",
"type": "progene_text",
"text": [
"Ultrasonography has recently been used for evaluation of various conditions in Orthopaedics ."
],
"offsets": [
[
0,
93
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3777 | split_0_train_3777 | [
{
"id": "split_0_train_3777_passage",
"type": "progene_text",
"text": [
"Ultrasonographic examination is a noninvasive screening test especially for soft tissue masses ."
],
"offsets": [
[
0,
96
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3778 | split_0_train_3778 | [
{
"id": "split_0_train_3778_passage",
"type": "progene_text",
"text": [
"Ultrasonography is also a useful and essential diagnostic tool in cardiovascular disorders because real - time images of heart and vessels can be obtained ."
],
"offsets": [
[
0,
156
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3779 | split_0_train_3779 | [
{
"id": "split_0_train_3779_passage",
"type": "progene_text",
"text": [
"However , there have been few reports which describe ultrasonographic evaluation of tumorous lesions in digital vessels ."
],
"offsets": [
[
0,
121
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3780 | split_0_train_3780 | [
{
"id": "split_0_train_3780_passage",
"type": "progene_text",
"text": [
"In this paper , such lesions in two cases were evaluated by ultrasonography ."
],
"offsets": [
[
0,
77
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3781 | split_0_train_3781 | [
{
"id": "split_0_train_3781_passage",
"type": "progene_text",
"text": [
"An aneurysm of the digital artery is one of the definite candidates for ultrasonographic evaluation ."
],
"offsets": [
[
0,
101
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3782 | split_0_train_3782 | [
{
"id": "split_0_train_3782_passage",
"type": "progene_text",
"text": [
"Novel proteins interacting with the leucine - rich repeat domain of human flightless-I identified by the yeast two - hybrid system ."
],
"offsets": [
[
0,
132
]
]
}
]
| [
{
"id": "split_0_train_6062_entity",
"type": "progene_text",
"text": [
"flightless-I"
],
"offsets": [
[
74,
86
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3783 | split_0_train_3783 | [
{
"id": "split_0_train_3783_passage",
"type": "progene_text",
"text": [
"The flightless-I gene encodes a member of the gelsolin - like family of actin - binding proteins linked to a leucine - rich repeat ( LRR ) domain ."
],
"offsets": [
[
0,
147
]
]
}
]
| [
{
"id": "split_0_train_6063_entity",
"type": "progene_text",
"text": [
"flightless-I"
],
"offsets": [
[
4,
16
]
],
"normalized": []
},
{
"id": "split_0_train_6064_entity",
"type": "progene_text",
"text": [
"gelsolin - like family of actin - binding proteins"
],
"offsets": [
[
46,
96
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3784 | split_0_train_3784 | [
{
"id": "split_0_train_3784_passage",
"type": "progene_text",
"text": [
"It is required for cellularization during early embryogenesis and normal development of the indirect flight muscles in Drosophila melanogaster ."
],
"offsets": [
[
0,
144
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3785 | split_0_train_3785 | [
{
"id": "split_0_train_3785_passage",
"type": "progene_text",
"text": [
"Although the association between actin and the gelsolin - like domain of the human Flightless-I homologue ( FLI ) has been established , its biological role is unknown ."
],
"offsets": [
[
0,
169
]
]
}
]
| [
{
"id": "split_0_train_6065_entity",
"type": "progene_text",
"text": [
"actin"
],
"offsets": [
[
33,
38
]
],
"normalized": []
},
{
"id": "split_0_train_6066_entity",
"type": "progene_text",
"text": [
"gelsolin"
],
"offsets": [
[
47,
55
]
],
"normalized": []
},
{
"id": "split_0_train_6067_entity",
"type": "progene_text",
"text": [
"Flightless-I"
],
"offsets": [
[
83,
95
]
],
"normalized": []
},
{
"id": "split_0_train_6068_entity",
"type": "progene_text",
"text": [
"FLI"
],
"offsets": [
[
108,
111
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3786 | split_0_train_3786 | [
{
"id": "split_0_train_3786_passage",
"type": "progene_text",
"text": [
"The human FLI gene is mapped within the Smith - Magenis microdeletion region of chromosome 17 ."
],
"offsets": [
[
0,
95
]
]
}
]
| [
{
"id": "split_0_train_6069_entity",
"type": "progene_text",
"text": [
"FLI"
],
"offsets": [
[
10,
13
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3787 | split_0_train_3787 | [
{
"id": "split_0_train_3787_passage",
"type": "progene_text",
"text": [
"We report the identification of two related genes , LRRFIP1 and LRRFIP2 , encoding proteins that interact with the LRR domain of human FLI using the yeast two - hybrid system ."
],
"offsets": [
[
0,
176
]
]
}
]
| [
{
"id": "split_0_train_6070_entity",
"type": "progene_text",
"text": [
"LRRFIP1"
],
"offsets": [
[
52,
59
]
],
"normalized": []
},
{
"id": "split_0_train_6071_entity",
"type": "progene_text",
"text": [
"LRRFIP2"
],
"offsets": [
[
64,
71
]
],
"normalized": []
},
{
"id": "split_0_train_6072_entity",
"type": "progene_text",
"text": [
"FLI"
],
"offsets": [
[
135,
138
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3788 | split_0_train_3788 | [
{
"id": "split_0_train_3788_passage",
"type": "progene_text",
"text": [
"LRRFIP1 exhibits sequence identity with the TRIP RNA - binding protein and GCF-2 transcriptional repressor , which are also related to the murine FLAP-1 gene ."
],
"offsets": [
[
0,
159
]
]
}
]
| [
{
"id": "split_0_train_6073_entity",
"type": "progene_text",
"text": [
"LRRFIP1"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "split_0_train_6074_entity",
"type": "progene_text",
"text": [
"TRIP"
],
"offsets": [
[
44,
48
]
],
"normalized": []
},
{
"id": "split_0_train_6075_entity",
"type": "progene_text",
"text": [
"GCF-2"
],
"offsets": [
[
75,
80
]
],
"normalized": []
},
{
"id": "split_0_train_6076_entity",
"type": "progene_text",
"text": [
"FLAP-1"
],
"offsets": [
[
146,
152
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3789 | split_0_train_3789 | [
{
"id": "split_0_train_3789_passage",
"type": "progene_text",
"text": [
"LRRFIP2 is a novel gene that shares sequence homology with LRRFIP1 and FLAP-1 ."
],
"offsets": [
[
0,
79
]
]
}
]
| [
{
"id": "split_0_train_6077_entity",
"type": "progene_text",
"text": [
"LRRFIP2"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "split_0_train_6078_entity",
"type": "progene_text",
"text": [
"LRRFIP1"
],
"offsets": [
[
59,
66
]
],
"normalized": []
},
{
"id": "split_0_train_6079_entity",
"type": "progene_text",
"text": [
"FLAP-1"
],
"offsets": [
[
71,
77
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3790 | split_0_train_3790 | [
{
"id": "split_0_train_3790_passage",
"type": "progene_text",
"text": [
"LRRFIP1 and LRRFIP2 both express alternative splice variants in heart and skeletal muscle tissue ."
],
"offsets": [
[
0,
98
]
]
}
]
| [
{
"id": "split_0_train_6080_entity",
"type": "progene_text",
"text": [
"LRRFIP1"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "split_0_train_6081_entity",
"type": "progene_text",
"text": [
"LRRFIP2"
],
"offsets": [
[
12,
19
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3791 | split_0_train_3791 | [
{
"id": "split_0_train_3791_passage",
"type": "progene_text",
"text": [
"A coiled - coil domain , conserved within each encoded protein , serves as a potential interaction motif for FLI LRR ."
],
"offsets": [
[
0,
118
]
]
}
]
| [
{
"id": "split_0_train_6082_entity",
"type": "progene_text",
"text": [
"FLI"
],
"offsets": [
[
109,
112
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3792 | split_0_train_3792 | [
{
"id": "split_0_train_3792_passage",
"type": "progene_text",
"text": [
"The occurrence of multiple proteins able to interact with FLI within the same tissue suggests that they may compete for the same binding site ."
],
"offsets": [
[
0,
143
]
]
}
]
| [
{
"id": "split_0_train_6083_entity",
"type": "progene_text",
"text": [
"FLI"
],
"offsets": [
[
58,
61
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3793 | split_0_train_3793 | [
{
"id": "split_0_train_3793_passage",
"type": "progene_text",
"text": [
"Sequencing and PCR - directed genomic analysis indicate that LRRFIP1 and LRRFIP2 are related genes that arose from gene duplication ."
],
"offsets": [
[
0,
133
]
]
}
]
| [
{
"id": "split_0_train_6084_entity",
"type": "progene_text",
"text": [
"LRRFIP1"
],
"offsets": [
[
61,
68
]
],
"normalized": []
},
{
"id": "split_0_train_6085_entity",
"type": "progene_text",
"text": [
"LRRFIP2"
],
"offsets": [
[
73,
80
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3794 | split_0_train_3794 | [
{
"id": "split_0_train_3794_passage",
"type": "progene_text",
"text": [
"Probing activation of the prokaryotic arginine transcriptional regulator using chimeric proteins ."
],
"offsets": [
[
0,
98
]
]
}
]
| [
{
"id": "split_0_train_6086_entity",
"type": "progene_text",
"text": [
"arginine transcriptional regulator"
],
"offsets": [
[
38,
72
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3795 | split_0_train_3795 | [
{
"id": "split_0_train_3795_passage",
"type": "progene_text",
"text": [
"The major transcription factors controlling arginine metabolism in Escherichia coli and Bacillus subtilis , ArgR and AhrC , respectively , are homologous multimeric proteins that form l - arginine - dependent DNA - binding complexes capable of repressing transcription of the biosynthetic genes ( both ) , activating transcription of catabolic genes ( AhrC only ) or facilitating plasmid dimer resolution ( both ) ."
],
"offsets": [
[
0,
415
]
]
}
]
| [
{
"id": "split_0_train_6087_entity",
"type": "progene_text",
"text": [
"transcription factors"
],
"offsets": [
[
10,
31
]
],
"normalized": []
},
{
"id": "split_0_train_6088_entity",
"type": "progene_text",
"text": [
"ArgR"
],
"offsets": [
[
108,
112
]
],
"normalized": []
},
{
"id": "split_0_train_6089_entity",
"type": "progene_text",
"text": [
"AhrC"
],
"offsets": [
[
117,
121
]
],
"normalized": []
},
{
"id": "split_0_train_6090_entity",
"type": "progene_text",
"text": [
"AhrC"
],
"offsets": [
[
352,
356
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3796 | split_0_train_3796 | [
{
"id": "split_0_train_3796_passage",
"type": "progene_text",
"text": [
"Multimerisation and l - arginine binding are associated with the C - terminal 70 - 80 residues ; the N-terminal regions contain a winged helix - turn - helix DNA - binding domain ."
],
"offsets": [
[
0,
180
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3797 | split_0_train_3797 | [
{
"id": "split_0_train_3797_passage",
"type": "progene_text",
"text": [
"We have constructed chimeric genes in which the sequences for the N and C - terminal domains have been swapped ."
],
"offsets": [
[
0,
112
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3798 | split_0_train_3798 | [
{
"id": "split_0_train_3798_passage",
"type": "progene_text",
"text": [
"The resultant chimeric proteins and their corresponding native proteins have been analysed for their ability to multimerise and bind DNA operator sites in an L-arginine - dependent fashion.Gel filtration and equilibrium sedimentation analysis are consistent with the formation of hexamers by all four proteins in the presence of L-arginine and at high protein concentrations ( > 100 nM monomer ) ."
],
"offsets": [
[
0,
397
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3799 | split_0_train_3799 | [
{
"id": "split_0_train_3799_passage",
"type": "progene_text",
"text": [
"The hexamer sedimentation coefficients suggest that there is a reduction in molecular volume upon binding L-arginine , consistent with a conformational change accompanying an allosteric activation of DNA - binding ."
],
"offsets": [
[
0,
215
]
]
}
]
| []
| []
| []
| []
|
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