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stringlengths 15
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stringlengths 15
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list | entities
list | events
list | coreferences
list | relations
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|---|---|---|---|---|---|---|
split_0_train_3600 | split_0_train_3600 | [
{
"id": "split_0_train_3600_passage",
"type": "progene_text",
"text": [
"Transforming growth factor - beta1 induces interleukin-6 expression via activating protein-1 consisting of JunD homodimers in primary human lung fibroblasts ."
],
"offsets": [
[
0,
158
]
]
}
]
| [
{
"id": "split_0_train_5888_entity",
"type": "progene_text",
"text": [
"Transforming growth factor - beta1"
],
"offsets": [
[
0,
34
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],
"normalized": []
},
{
"id": "split_0_train_5889_entity",
"type": "progene_text",
"text": [
"interleukin-6"
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[
43,
56
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],
"normalized": []
},
{
"id": "split_0_train_5890_entity",
"type": "progene_text",
"text": [
"activating protein-1"
],
"offsets": [
[
72,
92
]
],
"normalized": []
},
{
"id": "split_0_train_5891_entity",
"type": "progene_text",
"text": [
"JunD"
],
"offsets": [
[
107,
111
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3601 | split_0_train_3601 | [
{
"id": "split_0_train_3601_passage",
"type": "progene_text",
"text": [
"Transforming growth factor ( TGF ) - beta1 induces extracellular matrix deposition and proliferation of mesenchymal cells ."
],
"offsets": [
[
0,
123
]
]
}
]
| [
{
"id": "split_0_train_5892_entity",
"type": "progene_text",
"text": [
"Transforming growth factor ( TGF ) - beta1"
],
"offsets": [
[
0,
42
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3602 | split_0_train_3602 | [
{
"id": "split_0_train_3602_passage",
"type": "progene_text",
"text": [
"We recently reported that interleukin ( IL ) - 6 is an essential mediator of growth factor - induced proliferation of lung fibroblasts ."
],
"offsets": [
[
0,
136
]
]
}
]
| [
{
"id": "split_0_train_5893_entity",
"type": "progene_text",
"text": [
"interleukin ( IL ) - 6"
],
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[
26,
48
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"normalized": []
},
{
"id": "split_0_train_5894_entity",
"type": "progene_text",
"text": [
"growth factor"
],
"offsets": [
[
77,
90
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3603 | split_0_train_3603 | [
{
"id": "split_0_train_3603_passage",
"type": "progene_text",
"text": [
"Here , we demonstrate by reverse transcriptase polymerase chain reaction and enzyme - linked immunoassay that TGF-beta1 is a potent inducer of IL-6 mRNA and protein in primary human lung fibroblasts ."
],
"offsets": [
[
0,
200
]
]
}
]
| [
{
"id": "split_0_train_5895_entity",
"type": "progene_text",
"text": [
"TGF-beta1"
],
"offsets": [
[
110,
119
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],
"normalized": []
},
{
"id": "split_0_train_5896_entity",
"type": "progene_text",
"text": [
"IL-6"
],
"offsets": [
[
143,
147
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3604 | split_0_train_3604 | [
{
"id": "split_0_train_3604_passage",
"type": "progene_text",
"text": [
"Transient transfections of fibroblasts with a luciferase reporter gene construct containing nucleotides - 651 to + 1 of the human IL-6 promoter revealed that TGF-beta1 also potently activated IL-6 promoter activity ."
],
"offsets": [
[
0,
216
]
]
}
]
| [
{
"id": "split_0_train_5897_entity",
"type": "progene_text",
"text": [
"luciferase"
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"offsets": [
[
46,
56
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],
"normalized": []
},
{
"id": "split_0_train_5898_entity",
"type": "progene_text",
"text": [
"IL-6"
],
"offsets": [
[
130,
134
]
],
"normalized": []
},
{
"id": "split_0_train_5899_entity",
"type": "progene_text",
"text": [
"TGF-beta1"
],
"offsets": [
[
158,
167
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],
"normalized": []
},
{
"id": "split_0_train_5900_entity",
"type": "progene_text",
"text": [
"IL-6"
],
"offsets": [
[
192,
196
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3605 | split_0_train_3605 | [
{
"id": "split_0_train_3605_passage",
"type": "progene_text",
"text": [
"Progressive 5'-deletions and site - directed mutagenesis of the parental construct located the TGF-beta1 - responsive cis - regulatory element to a known activating protein-1 ( AP-1 ) sequence ( nucleotides - 284 to - 276 ) ."
],
"offsets": [
[
0,
225
]
]
}
]
| [
{
"id": "split_0_train_5901_entity",
"type": "progene_text",
"text": [
"TGF-beta1"
],
"offsets": [
[
95,
104
]
],
"normalized": []
},
{
"id": "split_0_train_5902_entity",
"type": "progene_text",
"text": [
"activating protein-1"
],
"offsets": [
[
154,
174
]
],
"normalized": []
},
{
"id": "split_0_train_5903_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
177,
181
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3606 | split_0_train_3606 | [
{
"id": "split_0_train_3606_passage",
"type": "progene_text",
"text": [
"Gel shift analyses revealed that AP-1 DNA binding activity in nuclear extracts was increased 30 min after stimulation with TGF-beta1 ."
],
"offsets": [
[
0,
134
]
]
}
]
| [
{
"id": "split_0_train_5904_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
33,
37
]
],
"normalized": []
},
{
"id": "split_0_train_5905_entity",
"type": "progene_text",
"text": [
"TGF-beta1"
],
"offsets": [
[
123,
132
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3607 | split_0_train_3607 | [
{
"id": "split_0_train_3607_passage",
"type": "progene_text",
"text": [
"In contrast , neither CCAAT enhancer - binding protein - beta , NF-kappaB , nor Sp1 were activated by TGF-beta1 ."
],
"offsets": [
[
0,
113
]
]
}
]
| [
{
"id": "split_0_train_5906_entity",
"type": "progene_text",
"text": [
"CCAAT enhancer - binding protein - beta"
],
"offsets": [
[
22,
61
]
],
"normalized": []
},
{
"id": "split_0_train_5907_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
64,
73
]
],
"normalized": []
},
{
"id": "split_0_train_5908_entity",
"type": "progene_text",
"text": [
"Sp1"
],
"offsets": [
[
80,
83
]
],
"normalized": []
},
{
"id": "split_0_train_5909_entity",
"type": "progene_text",
"text": [
"TGF-beta1"
],
"offsets": [
[
102,
111
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3608 | split_0_train_3608 | [
{
"id": "split_0_train_3608_passage",
"type": "progene_text",
"text": [
"Supershift analyses demonstrated that the AP-1 complex induced by TGF-beta1 was composed of Jun isoforms and absent of Fos isoforms ."
],
"offsets": [
[
0,
133
]
]
}
]
| [
{
"id": "split_0_train_5910_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
42,
46
]
],
"normalized": []
},
{
"id": "split_0_train_5911_entity",
"type": "progene_text",
"text": [
"TGF-beta1"
],
"offsets": [
[
66,
75
]
],
"normalized": []
},
{
"id": "split_0_train_5912_entity",
"type": "progene_text",
"text": [
"Jun"
],
"offsets": [
[
92,
95
]
],
"normalized": []
},
{
"id": "split_0_train_5913_entity",
"type": "progene_text",
"text": [
"Fos"
],
"offsets": [
[
119,
122
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3609 | split_0_train_3609 | [
{
"id": "split_0_train_3609_passage",
"type": "progene_text",
"text": [
"Moreover , this complex was found to be a JunD homodimer ."
],
"offsets": [
[
0,
58
]
]
}
]
| [
{
"id": "split_0_train_5914_entity",
"type": "progene_text",
"text": [
"JunD"
],
"offsets": [
[
42,
46
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3610 | split_0_train_3610 | [
{
"id": "split_0_train_3610_passage",
"type": "progene_text",
"text": [
"Our data thus demonstrate that TGF-beta1 is a potent inducer of IL-6 in primary human lung fibroblasts ."
],
"offsets": [
[
0,
104
]
]
}
]
| [
{
"id": "split_0_train_5915_entity",
"type": "progene_text",
"text": [
"TGF-beta1"
],
"offsets": [
[
31,
40
]
],
"normalized": []
},
{
"id": "split_0_train_5916_entity",
"type": "progene_text",
"text": [
"IL-6"
],
"offsets": [
[
64,
68
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3611 | split_0_train_3611 | [
{
"id": "split_0_train_3611_passage",
"type": "progene_text",
"text": [
"The TGF-beta1 - activated JunD homodimer may be essential for a majority of the biological effects induced by TGF-beta1 in this cell type , such as proliferation and extracellular matrix synthesis ."
],
"offsets": [
[
0,
198
]
]
}
]
| [
{
"id": "split_0_train_5917_entity",
"type": "progene_text",
"text": [
"TGF-beta1"
],
"offsets": [
[
4,
13
]
],
"normalized": []
},
{
"id": "split_0_train_5918_entity",
"type": "progene_text",
"text": [
"JunD"
],
"offsets": [
[
26,
30
]
],
"normalized": []
},
{
"id": "split_0_train_5919_entity",
"type": "progene_text",
"text": [
"TGF-beta1"
],
"offsets": [
[
110,
119
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3612 | split_0_train_3612 | [
{
"id": "split_0_train_3612_passage",
"type": "progene_text",
"text": [
"Patients ' perception of visual impairment in glaucoma : a pilot study ."
],
"offsets": [
[
0,
72
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3613 | split_0_train_3613 | [
{
"id": "split_0_train_3613_passage",
"type": "progene_text",
"text": [
"BACKGROUND / AIMS :"
],
"offsets": [
[
0,
19
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3614 | split_0_train_3614 | [
{
"id": "split_0_train_3614_passage",
"type": "progene_text",
"text": [
"There is a paucity of useful information on the level of visual disability suffered by glaucoma patients ."
],
"offsets": [
[
0,
106
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3615 | split_0_train_3615 | [
{
"id": "split_0_train_3615_passage",
"type": "progene_text",
"text": [
"The aims of this study were to determine and rank the frequency of self reported visual disability in daily tasks performed by glaucoma patients ; to examine the interrelation between disabilities using factor analysis ; to study the relation between perceived visual difficulty and a measure of the severity of visual field loss ; to develop a glaucoma specific subgroup of questions ; and examine the validity and reliability of this subgroup of questions ."
],
"offsets": [
[
0,
459
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3616 | split_0_train_3616 | [
{
"id": "split_0_train_3616_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3617 | split_0_train_3617 | [
{
"id": "split_0_train_3617_passage",
"type": "progene_text",
"text": [
"63 glaucoma patients completed a questionnaire containing 62 questions covering 10 broad aspects of daily life activities using a five point answer scale ."
],
"offsets": [
[
0,
155
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3618 | split_0_train_3618 | [
{
"id": "split_0_train_3618_passage",
"type": "progene_text",
"text": [
"Patients were classified into three groups as having mild , moderate , and severe field loss on the basis of the perimetric results ."
],
"offsets": [
[
0,
133
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3619 | split_0_train_3619 | [
{
"id": "split_0_train_3619_passage",
"type": "progene_text",
"text": [
"The relation between a measure of the severity of visual field loss and subjective visual disability in the three groups was examined ."
],
"offsets": [
[
0,
135
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3620 | split_0_train_3620 | [
{
"id": "split_0_train_3620_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3621 | split_0_train_3621 | [
{
"id": "split_0_train_3621_passage",
"type": "progene_text",
"text": [
"Using factor analysis , the most frequently reported problems were grouped into the following four categories : outdoor mobility , glare and lighting conditions and activities demanding functional peripheral vision , household tasks , and personal care ."
],
"offsets": [
[
0,
254
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3622 | split_0_train_3622 | [
{
"id": "split_0_train_3622_passage",
"type": "progene_text",
"text": [
"These four factors accounted for 72 % of the variability in the patients ' questionnaire responses ."
],
"offsets": [
[
0,
100
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3623 | split_0_train_3623 | [
{
"id": "split_0_train_3623_passage",
"type": "progene_text",
"text": [
"With increasing severity of binocular visual field loss there was an increase in the number of self reported visual problems ."
],
"offsets": [
[
0,
126
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3624 | split_0_train_3624 | [
{
"id": "split_0_train_3624_passage",
"type": "progene_text",
"text": [
"A loss of confidence in performing some routine daily tasks tended to precede self reported specific visual disabilities ."
],
"offsets": [
[
0,
122
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3625 | split_0_train_3625 | [
{
"id": "split_0_train_3625_passage",
"type": "progene_text",
"text": [
"The factor \" glare and lighting and activities demanding functional peripheral vision \" was found to have a significant relation with a measure of visual field loss and was used to create a glaucoma specific subset of questions ."
],
"offsets": [
[
0,
229
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3626 | split_0_train_3626 | [
{
"id": "split_0_train_3626_passage",
"type": "progene_text",
"text": [
"Cronbach 's alpha showed a high degree of reliability and internal consistency ( alpha = 0.96 ) in this glaucoma specific subset of questions ."
],
"offsets": [
[
0,
143
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3627 | split_0_train_3627 | [
{
"id": "split_0_train_3627_passage",
"type": "progene_text",
"text": [
"Furthermore , the validity of this new subset of questions was shown to be significant ( r = 0.037 , p < 0.05 ) for the correlation between a measure of the severity of binocular visual field loss and the mean score of the variables used in the glaucoma specific subgroup of questions ."
],
"offsets": [
[
0,
286
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3628 | split_0_train_3628 | [
{
"id": "split_0_train_3628_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3629 | split_0_train_3629 | [
{
"id": "split_0_train_3629_passage",
"type": "progene_text",
"text": [
"Outcome measures and quality of life issues need to be addressed in glaucoma ."
],
"offsets": [
[
0,
78
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3630 | split_0_train_3630 | [
{
"id": "split_0_train_3630_passage",
"type": "progene_text",
"text": [
"This pilot study identified common problems encountered by patients which at the present time are not assessed in routine glaucoma care ."
],
"offsets": [
[
0,
137
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3631 | split_0_train_3631 | [
{
"id": "split_0_train_3631_passage",
"type": "progene_text",
"text": [
"It also identified a subgroup of questions that seems to be specific for glaucoma ."
],
"offsets": [
[
0,
83
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3632 | split_0_train_3632 | [
{
"id": "split_0_train_3632_passage",
"type": "progene_text",
"text": [
"Further research is required if a significant impact on the quality of life of glaucoma patients is to be achieved ."
],
"offsets": [
[
0,
116
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3633 | split_0_train_3633 | [
{
"id": "split_0_train_3633_passage",
"type": "progene_text",
"text": [
"Constrictive pericarditis and pleuropulmonary disease linked to ergot dopamine agonist therapy ( cabergoline ) for Parkinson 's disease ."
],
"offsets": [
[
0,
137
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3634 | split_0_train_3634 | [
{
"id": "split_0_train_3634_passage",
"type": "progene_text",
"text": [
"Cabergoline is one of several ergoline dopamine agonist medications used in the treatment of Parkinson 's disease ( PD ) ."
],
"offsets": [
[
0,
122
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3635 | split_0_train_3635 | [
{
"id": "split_0_train_3635_passage",
"type": "progene_text",
"text": [
"We diagnosed constrictive pericarditis ( CP ) in a patient with PD receiving cabergoline therapy ( 10 mg daily ) , who had symptoms and signs of congestive heart failure ( CHF ) ."
],
"offsets": [
[
0,
179
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3636 | split_0_train_3636 | [
{
"id": "split_0_train_3636_passage",
"type": "progene_text",
"text": [
"In the absence of previous reported cases of this condition linked to ergoline drugs , cabergoline was not initially identified as the cause ."
],
"offsets": [
[
0,
142
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3637 | split_0_train_3637 | [
{
"id": "split_0_train_3637_passage",
"type": "progene_text",
"text": [
"Shortly thereafter , however , the patient developed of a severe pleuropulmonary inflammatory - fibrotic syndrome , a recognized complication of ergoline medications , thus suggesting a common pathogenesis due to cabergoline therapy ."
],
"offsets": [
[
0,
234
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3638 | split_0_train_3638 | [
{
"id": "split_0_train_3638_passage",
"type": "progene_text",
"text": [
"To our knowledge , this is the first case in the English literature , although we speculate that CP may be more common than reported among patients with PD who are treated with an ergoline drug ( cabergoline , bromocriptine , pergolide , or lisuride ) ."
],
"offsets": [
[
0,
253
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3639 | split_0_train_3639 | [
{
"id": "split_0_train_3639_passage",
"type": "progene_text",
"text": [
"The diagnosis of CP is difficult and requires a high level of suspicion ; symptoms may masquerade as CHF due to common mechanisms such as coronary artery disease ."
],
"offsets": [
[
0,
163
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3640 | split_0_train_3640 | [
{
"id": "split_0_train_3640_passage",
"type": "progene_text",
"text": [
"In patients with PD who are taking not only cabergoline but also one of the other ergoline drugs , CP should be suspected if symptoms of CHF develop ."
],
"offsets": [
[
0,
150
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3641 | split_0_train_3641 | [
{
"id": "split_0_train_3641_passage",
"type": "progene_text",
"text": [
"Gene arrangement and RNA transcription of the BamHI fragments K and M2 within the non - oncogenic Marek 's disease virus serotype 2 unique long genome region ."
],
"offsets": [
[
0,
159
]
]
}
]
| [
{
"id": "split_0_train_5920_entity",
"type": "progene_text",
"text": [
"BamHI"
],
"offsets": [
[
46,
51
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3642 | split_0_train_3642 | [
{
"id": "split_0_train_3642_passage",
"type": "progene_text",
"text": [
"We determined the nucleotide sequence of a 6593 bp fragment of the Marek 's disease virus serotype 2 ( MDV2 ) unique long region located in the right part of genomic BamHI - M2 and the adjacent part of BamHI - K fragments ."
],
"offsets": [
[
0,
223
]
]
}
]
| [
{
"id": "split_0_train_5921_entity",
"type": "progene_text",
"text": [
"BamHI"
],
"offsets": [
[
166,
171
]
],
"normalized": []
},
{
"id": "split_0_train_5922_entity",
"type": "progene_text",
"text": [
"BamHI"
],
"offsets": [
[
202,
207
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3643 | split_0_train_3643 | [
{
"id": "split_0_train_3643_passage",
"type": "progene_text",
"text": [
"Within this region five complete open reading frames ( ORFs ) were identified whose deduced amino acid sequences exhibited homology to the UL53 ( glycoprotein K ) , UL54 ( immediate early regulatory protein ICP27 ) , and UL55 gene products of herpes simplex virus type 1 ( HSV-1 ) ."
],
"offsets": [
[
0,
282
]
]
}
]
| [
{
"id": "split_0_train_5923_entity",
"type": "progene_text",
"text": [
"UL53"
],
"offsets": [
[
139,
143
]
],
"normalized": []
},
{
"id": "split_0_train_5924_entity",
"type": "progene_text",
"text": [
"glycoprotein K"
],
"offsets": [
[
146,
160
]
],
"normalized": []
},
{
"id": "split_0_train_5925_entity",
"type": "progene_text",
"text": [
"UL54"
],
"offsets": [
[
165,
169
]
],
"normalized": []
},
{
"id": "split_0_train_5926_entity",
"type": "progene_text",
"text": [
"immediate early regulatory protein ICP27"
],
"offsets": [
[
172,
212
]
],
"normalized": []
},
{
"id": "split_0_train_5927_entity",
"type": "progene_text",
"text": [
"UL55"
],
"offsets": [
[
221,
225
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3644 | split_0_train_3644 | [
{
"id": "split_0_train_3644_passage",
"type": "progene_text",
"text": [
"Homologue to the HSV-1 UL56 was not detected ."
],
"offsets": [
[
0,
46
]
]
}
]
| [
{
"id": "split_0_train_5928_entity",
"type": "progene_text",
"text": [
"UL56"
],
"offsets": [
[
23,
27
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3645 | split_0_train_3645 | [
{
"id": "split_0_train_3645_passage",
"type": "progene_text",
"text": [
"However , we identified a gene between the MDV2 UL54 and UL55 genes with homology to the first ORF ( ORF-1 ) of equine herpesvirus type 1 and corresponding gene identified in pseudorabies virus ."
],
"offsets": [
[
0,
195
]
]
}
]
| [
{
"id": "split_0_train_5929_entity",
"type": "progene_text",
"text": [
"UL54"
],
"offsets": [
[
48,
52
]
],
"normalized": []
},
{
"id": "split_0_train_5930_entity",
"type": "progene_text",
"text": [
"UL55"
],
"offsets": [
[
57,
61
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3646 | split_0_train_3646 | [
{
"id": "split_0_train_3646_passage",
"type": "progene_text",
"text": [
"Two adjacent ORFs contained in the BamHI - K fragment , ORF 873s and ORF 873 , were found by computer analysis to have the properties of an intron encoding a glycoprotein : ORF 873s encodes a 84 amino acid polypeptide with a stretch of a hydrophobic signal sequence in the C - terminus , and ORF 873 encodes a 873 amino acid polypeptide with a transmembrane domain and putative three N - linked glycosylation sites ."
],
"offsets": [
[
0,
416
]
]
}
]
| [
{
"id": "split_0_train_5931_entity",
"type": "progene_text",
"text": [
"BamHI"
],
"offsets": [
[
35,
40
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3647 | split_0_train_3647 | [
{
"id": "split_0_train_3647_passage",
"type": "progene_text",
"text": [
"All the identified genes were confirmed to be transcribed with 3'-coterminal transcripts and/or a unique transcript in the virus - infected cells ."
],
"offsets": [
[
0,
147
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3648 | split_0_train_3648 | [
{
"id": "split_0_train_3648_passage",
"type": "progene_text",
"text": [
"Especially , 3.5 kb mRNA of ORF 873s and ORF 873 are transcribed from a potential promoter region of ORF 873s , and splice donor and acceptor sites are used to splice the mRNA after cleavage of a 113 bp - nucleotide sequence ."
],
"offsets": [
[
0,
226
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3649 | split_0_train_3649 | [
{
"id": "split_0_train_3649_passage",
"type": "progene_text",
"text": [
"Molecular alterations of the Fyn - complex occur as late events of human T cell activation ."
],
"offsets": [
[
0,
92
]
]
}
]
| [
{
"id": "split_0_train_5932_entity",
"type": "progene_text",
"text": [
"Fyn"
],
"offsets": [
[
29,
32
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3650 | split_0_train_3650 | [
{
"id": "split_0_train_3650_passage",
"type": "progene_text",
"text": [
"Two - dimensional gel electrophoresis of anti - p59fyn immunoprecipitates obtained from non - transformed resting human T lymphocytes resulted in the identification of an oligomeric protein complex which is constitutively formed between Fyn and several additional phosphoproteins ( pp43 , pp72 , pp85 , the protein tyrosine kinase Pyk2 , as well as the two recently cloned adaptor proteins , SKAP55 and SLAP-130 ) ."
],
"offsets": [
[
0,
415
]
]
}
]
| [
{
"id": "split_0_train_5933_entity",
"type": "progene_text",
"text": [
"p59fyn"
],
"offsets": [
[
48,
54
]
],
"normalized": []
},
{
"id": "split_0_train_5934_entity",
"type": "progene_text",
"text": [
"Fyn"
],
"offsets": [
[
237,
240
]
],
"normalized": []
},
{
"id": "split_0_train_5935_entity",
"type": "progene_text",
"text": [
"protein tyrosine kinase"
],
"offsets": [
[
307,
330
]
],
"normalized": []
},
{
"id": "split_0_train_5936_entity",
"type": "progene_text",
"text": [
"Pyk2"
],
"offsets": [
[
331,
335
]
],
"normalized": []
},
{
"id": "split_0_train_5937_entity",
"type": "progene_text",
"text": [
"adaptor proteins"
],
"offsets": [
[
373,
389
]
],
"normalized": []
},
{
"id": "split_0_train_5938_entity",
"type": "progene_text",
"text": [
"SKAP55"
],
"offsets": [
[
392,
398
]
],
"normalized": []
},
{
"id": "split_0_train_5939_entity",
"type": "progene_text",
"text": [
"SLAP-130"
],
"offsets": [
[
403,
411
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3651 | split_0_train_3651 | [
{
"id": "split_0_train_3651_passage",
"type": "progene_text",
"text": [
"With the exception of pp85 , these proteins seem to preferentially interact with Fyn since they are not detectable in Lck immunoprecipitates prepared under the same experimental conditions ."
],
"offsets": [
[
0,
190
]
]
}
]
| [
{
"id": "split_0_train_5940_entity",
"type": "progene_text",
"text": [
"Fyn"
],
"offsets": [
[
81,
84
]
],
"normalized": []
},
{
"id": "split_0_train_5941_entity",
"type": "progene_text",
"text": [
"Lck"
],
"offsets": [
[
118,
121
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3652 | split_0_train_3652 | [
{
"id": "split_0_train_3652_passage",
"type": "progene_text",
"text": [
"Among the individual members of the Fyn - complex pp85 , SKAP55 and pp43 are constitutively phosphorylated on tyrosine residue (s) in vivo and likely interact with Fyn via its src homology 2 ( SH2 ) - domain ."
],
"offsets": [
[
0,
209
]
]
}
]
| [
{
"id": "split_0_train_5942_entity",
"type": "progene_text",
"text": [
"Fyn"
],
"offsets": [
[
36,
39
]
],
"normalized": []
},
{
"id": "split_0_train_5943_entity",
"type": "progene_text",
"text": [
"SKAP55"
],
"offsets": [
[
57,
63
]
],
"normalized": []
},
{
"id": "split_0_train_5944_entity",
"type": "progene_text",
"text": [
"Fyn"
],
"offsets": [
[
164,
167
]
],
"normalized": []
},
{
"id": "split_0_train_5945_entity",
"type": "progene_text",
"text": [
"src"
],
"offsets": [
[
176,
179
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3653 | split_0_train_3653 | [
{
"id": "split_0_train_3653_passage",
"type": "progene_text",
"text": [
"In contrast to non - transformed T lymphocytes , continuously proliferating transformed human T cell lines express an altered Fyn - complex ."
],
"offsets": [
[
0,
141
]
]
}
]
| [
{
"id": "split_0_train_5946_entity",
"type": "progene_text",
"text": [
"Fyn"
],
"offsets": [
[
126,
129
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3654 | split_0_train_3654 | [
{
"id": "split_0_train_3654_passage",
"type": "progene_text",
"text": [
"Thus , despite normal expression and tyrosine phosphorylation , SKAP55 does not associate with Fyn in Jurkat cells and in other human T cell lines ."
],
"offsets": [
[
0,
148
]
]
}
]
| [
{
"id": "split_0_train_5947_entity",
"type": "progene_text",
"text": [
"SKAP55"
],
"offsets": [
[
64,
70
]
],
"normalized": []
},
{
"id": "split_0_train_5948_entity",
"type": "progene_text",
"text": [
"Fyn"
],
"offsets": [
[
95,
98
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3655 | split_0_train_3655 | [
{
"id": "split_0_train_3655_passage",
"type": "progene_text",
"text": [
"Instead two novel proteins interact with Fyn among which one has previously been identified as alpha-tubulin ."
],
"offsets": [
[
0,
110
]
]
}
]
| [
{
"id": "split_0_train_5949_entity",
"type": "progene_text",
"text": [
"Fyn"
],
"offsets": [
[
41,
44
]
],
"normalized": []
},
{
"id": "split_0_train_5950_entity",
"type": "progene_text",
"text": [
"alpha-tubulin"
],
"offsets": [
[
95,
108
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3656 | split_0_train_3656 | [
{
"id": "split_0_train_3656_passage",
"type": "progene_text",
"text": [
"Importantly , almost identical alterations of the Fyn - complex as observed in Jurkat cells are induced in non - transformed T lymphocytes following mitogenic stimulation ."
],
"offsets": [
[
0,
172
]
]
}
]
| [
{
"id": "split_0_train_5951_entity",
"type": "progene_text",
"text": [
"Fyn"
],
"offsets": [
[
50,
53
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3657 | split_0_train_3657 | [
{
"id": "split_0_train_3657_passage",
"type": "progene_text",
"text": [
"These data suggest that Fyn and its associated proteins could be involved in the control of human T cell proliferation ."
],
"offsets": [
[
0,
120
]
]
}
]
| [
{
"id": "split_0_train_5952_entity",
"type": "progene_text",
"text": [
"Fyn"
],
"offsets": [
[
24,
27
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3658 | split_0_train_3658 | [
{
"id": "split_0_train_3658_passage",
"type": "progene_text",
"text": [
"Moreover , the analogous constitutive alterations in transformed T cell lines could indicate that deregulation of the Fyn - complex might be functionally associated with the malignant phenotype of these cells ."
],
"offsets": [
[
0,
210
]
]
}
]
| [
{
"id": "split_0_train_5953_entity",
"type": "progene_text",
"text": [
"Fyn"
],
"offsets": [
[
118,
121
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3659 | split_0_train_3659 | [
{
"id": "split_0_train_3659_passage",
"type": "progene_text",
"text": [
"Prostate - specific antigen ( PSA ) promoter - driven androgen - inducible expression of sodium iodide symporter in prostate cancer cell lines ."
],
"offsets": [
[
0,
144
]
]
}
]
| [
{
"id": "split_0_train_5954_entity",
"type": "progene_text",
"text": [
"Prostate - specific antigen"
],
"offsets": [
[
0,
27
]
],
"normalized": []
},
{
"id": "split_0_train_5955_entity",
"type": "progene_text",
"text": [
"PSA"
],
"offsets": [
[
30,
33
]
],
"normalized": []
},
{
"id": "split_0_train_5956_entity",
"type": "progene_text",
"text": [
"sodium iodide symporter"
],
"offsets": [
[
89,
112
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3660 | split_0_train_3660 | [
{
"id": "split_0_train_3660_passage",
"type": "progene_text",
"text": [
"Currently , no curative therapy for metastatic prostate cancer exists ."
],
"offsets": [
[
0,
71
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3661 | split_0_train_3661 | [
{
"id": "split_0_train_3661_passage",
"type": "progene_text",
"text": [
"Causing prostate cancer cells to express functionally active sodium iodide symporter ( NIS ) would enable those cells to concentrate iodide from plasma and might offer the ability to treat prostate cancer with radioiodine ."
],
"offsets": [
[
0,
223
]
]
}
]
| [
{
"id": "split_0_train_5957_entity",
"type": "progene_text",
"text": [
"sodium iodide symporter"
],
"offsets": [
[
61,
84
]
],
"normalized": []
},
{
"id": "split_0_train_5958_entity",
"type": "progene_text",
"text": [
"NIS"
],
"offsets": [
[
87,
90
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3662 | split_0_train_3662 | [
{
"id": "split_0_train_3662_passage",
"type": "progene_text",
"text": [
"Therefore , the aim of our study was to achieve tissue - specific expression of full - length human NIS ( hNIS ) cDNA in the androgen - sensitive human prostatic adenocarcinoma cell line LNCaP and in subcell lines C4 , C4-2 , and C4-2b in vitro ."
],
"offsets": [
[
0,
246
]
]
}
]
| [
{
"id": "split_0_train_5959_entity",
"type": "progene_text",
"text": [
"NIS"
],
"offsets": [
[
100,
103
]
],
"normalized": []
},
{
"id": "split_0_train_5960_entity",
"type": "progene_text",
"text": [
"hNIS"
],
"offsets": [
[
106,
110
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3663 | split_0_train_3663 | [
{
"id": "split_0_train_3663_passage",
"type": "progene_text",
"text": [
"For this purpose , an expression vector was generated in which full - length hNIS cDNA coupled to the prostate - specific antigen ( PSA ) promoter has been ligated into the pEGFP-1 vector ( NIS / PSA - pEGFP-1 ) ."
],
"offsets": [
[
0,
213
]
]
}
]
| [
{
"id": "split_0_train_5961_entity",
"type": "progene_text",
"text": [
"hNIS"
],
"offsets": [
[
77,
81
]
],
"normalized": []
},
{
"id": "split_0_train_5962_entity",
"type": "progene_text",
"text": [
"prostate - specific antigen"
],
"offsets": [
[
102,
129
]
],
"normalized": []
},
{
"id": "split_0_train_5963_entity",
"type": "progene_text",
"text": [
"PSA"
],
"offsets": [
[
132,
135
]
],
"normalized": []
},
{
"id": "split_0_train_5964_entity",
"type": "progene_text",
"text": [
"NIS"
],
"offsets": [
[
190,
193
]
],
"normalized": []
},
{
"id": "split_0_train_5965_entity",
"type": "progene_text",
"text": [
"PSA"
],
"offsets": [
[
196,
199
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3664 | split_0_train_3664 | [
{
"id": "split_0_train_3664_passage",
"type": "progene_text",
"text": [
"The PSA promoter is responsible for androgen - dependent expression of PSA in benign and malignant prostate cells and was therefore used to mediate androgen - dependent prostate - specific expression of NIS ."
],
"offsets": [
[
0,
208
]
]
}
]
| [
{
"id": "split_0_train_5966_entity",
"type": "progene_text",
"text": [
"PSA"
],
"offsets": [
[
4,
7
]
],
"normalized": []
},
{
"id": "split_0_train_5967_entity",
"type": "progene_text",
"text": [
"PSA"
],
"offsets": [
[
71,
74
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3665 | split_0_train_3665 | [
{
"id": "split_0_train_3665_passage",
"type": "progene_text",
"text": [
"In addition , two control vectors were designed , which consist of the pEGFP-1 vector containing the PSA promoter without NIS cDNA ( PSA - pEGFP-1 ) and NIS cDNA without the PSA promoter ( NIS - pEGFP-1 ) ."
],
"offsets": [
[
0,
206
]
]
}
]
| [
{
"id": "split_0_train_5968_entity",
"type": "progene_text",
"text": [
"PSA"
],
"offsets": [
[
101,
104
]
],
"normalized": []
},
{
"id": "split_0_train_5969_entity",
"type": "progene_text",
"text": [
"NIS"
],
"offsets": [
[
122,
125
]
],
"normalized": []
},
{
"id": "split_0_train_5970_entity",
"type": "progene_text",
"text": [
"PSA"
],
"offsets": [
[
133,
136
]
],
"normalized": []
},
{
"id": "split_0_train_5971_entity",
"type": "progene_text",
"text": [
"NIS"
],
"offsets": [
[
153,
156
]
],
"normalized": []
},
{
"id": "split_0_train_5972_entity",
"type": "progene_text",
"text": [
"PSA"
],
"offsets": [
[
174,
177
]
],
"normalized": []
},
{
"id": "split_0_train_5973_entity",
"type": "progene_text",
"text": [
"NIS"
],
"offsets": [
[
189,
192
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3666 | split_0_train_3666 | [
{
"id": "split_0_train_3666_passage",
"type": "progene_text",
"text": [
"Prostate cancer cells were transiently transfected with each of the above - described expression vectors , incubated with or without androgen ( mibolerone ) for 48 h , and monitored for iodide uptake activity ."
],
"offsets": [
[
0,
210
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3667 | split_0_train_3667 | [
{
"id": "split_0_train_3667_passage",
"type": "progene_text",
"text": [
"In addition , stably transfected LNCaP cell lines were established for each vector ."
],
"offsets": [
[
0,
84
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3668 | split_0_train_3668 | [
{
"id": "split_0_train_3668_passage",
"type": "progene_text",
"text": [
"Prostate cells transfected with NIS / PSA - pEGFP-1 showed perchlorate - sensitive , androgen - dependent iodide uptake in a range comparable to that observed in control cell lines transfected with hNIS cDNA ."
],
"offsets": [
[
0,
209
]
]
}
]
| [
{
"id": "split_0_train_5974_entity",
"type": "progene_text",
"text": [
"NIS"
],
"offsets": [
[
32,
35
]
],
"normalized": []
},
{
"id": "split_0_train_5975_entity",
"type": "progene_text",
"text": [
"PSA"
],
"offsets": [
[
38,
41
]
],
"normalized": []
},
{
"id": "split_0_train_5976_entity",
"type": "progene_text",
"text": [
"hNIS"
],
"offsets": [
[
198,
202
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3669 | split_0_train_3669 | [
{
"id": "split_0_train_3669_passage",
"type": "progene_text",
"text": [
"Perchlorate - sensitive iodide uptake was not observed in cells transfected with NIS / PSA - pEGFP-1 and treated without androgen or in cells transfected with the control vectors ."
],
"offsets": [
[
0,
180
]
]
}
]
| [
{
"id": "split_0_train_5977_entity",
"type": "progene_text",
"text": [
"NIS"
],
"offsets": [
[
81,
84
]
],
"normalized": []
},
{
"id": "split_0_train_5978_entity",
"type": "progene_text",
"text": [
"PSA"
],
"offsets": [
[
87,
90
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3670 | split_0_train_3670 | [
{
"id": "split_0_train_3670_passage",
"type": "progene_text",
"text": [
"In addition , prostate cancer cell lines without PSA expression ( PC-3 and DU-145 ) did not show iodide uptake activity when transfected with NIS / PSA - pEGFP-1 ."
],
"offsets": [
[
0,
163
]
]
}
]
| [
{
"id": "split_0_train_5979_entity",
"type": "progene_text",
"text": [
"PSA"
],
"offsets": [
[
49,
52
]
],
"normalized": []
},
{
"id": "split_0_train_5980_entity",
"type": "progene_text",
"text": [
"NIS"
],
"offsets": [
[
142,
145
]
],
"normalized": []
},
{
"id": "split_0_train_5981_entity",
"type": "progene_text",
"text": [
"PSA"
],
"offsets": [
[
148,
151
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3671 | split_0_train_3671 | [
{
"id": "split_0_train_3671_passage",
"type": "progene_text",
"text": [
"Western blotting of LNCaP and C4-2b cell membranes transfected with NIS / PSA - pEGFP-1 using a monoclonal antibody that recognizes the COOH - terminus of hNIS revealed a band with a molecular weight of 90,000 that was not detected in androgen - deprived cells or in cells transfected with the control vectors , as well as a minor band at Mr 150,000 in transiently transfected LNCaP cell membranes ."
],
"offsets": [
[
0,
399
]
]
}
]
| [
{
"id": "split_0_train_5982_entity",
"type": "progene_text",
"text": [
"NIS"
],
"offsets": [
[
68,
71
]
],
"normalized": []
},
{
"id": "split_0_train_5983_entity",
"type": "progene_text",
"text": [
"PSA"
],
"offsets": [
[
74,
77
]
],
"normalized": []
},
{
"id": "split_0_train_5984_entity",
"type": "progene_text",
"text": [
"hNIS"
],
"offsets": [
[
155,
159
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3672 | split_0_train_3672 | [
{
"id": "split_0_train_3672_passage",
"type": "progene_text",
"text": [
"In conclusion , tissue - specific androgen - dependent iodide uptake activity has been induced in prostate cancer cells by PSA promoter - directed NIS expression ."
],
"offsets": [
[
0,
163
]
]
}
]
| [
{
"id": "split_0_train_5985_entity",
"type": "progene_text",
"text": [
"PSA"
],
"offsets": [
[
123,
126
]
],
"normalized": []
},
{
"id": "split_0_train_5986_entity",
"type": "progene_text",
"text": [
"NIS"
],
"offsets": [
[
147,
150
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3673 | split_0_train_3673 | [
{
"id": "split_0_train_3673_passage",
"type": "progene_text",
"text": [
"This study represents an initial step toward therapy of prostate cancer with radioiodine ."
],
"offsets": [
[
0,
90
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3674 | split_0_train_3674 | [
{
"id": "split_0_train_3674_passage",
"type": "progene_text",
"text": [
"Premarketing adverse drug experiences : data management procedures ."
],
"offsets": [
[
0,
68
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3675 | split_0_train_3675 | [
{
"id": "split_0_train_3675_passage",
"type": "progene_text",
"text": [
"Unexpected death occurring early in clinical trials ."
],
"offsets": [
[
0,
53
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3676 | split_0_train_3676 | [
{
"id": "split_0_train_3676_passage",
"type": "progene_text",
"text": [
"Reporting of adverse events occurring during clinical trials of investigational drugs is a complex and controversial issue ."
],
"offsets": [
[
0,
124
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3677 | split_0_train_3677 | [
{
"id": "split_0_train_3677_passage",
"type": "progene_text",
"text": [
"Even the interpretation of the term , \" adverse event , \" cannot be agreed upon by researchers ."
],
"offsets": [
[
0,
96
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3678 | split_0_train_3678 | [
{
"id": "split_0_train_3678_passage",
"type": "progene_text",
"text": [
"The ultimate adverse event , death , presents even a greater challenge ."
],
"offsets": [
[
0,
72
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3679 | split_0_train_3679 | [
{
"id": "split_0_train_3679_passage",
"type": "progene_text",
"text": [
"This paper presents an actual case of death during a clinical trial to illustrate a methodological approach to deal with such an event ."
],
"offsets": [
[
0,
136
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3680 | split_0_train_3680 | [
{
"id": "split_0_train_3680_passage",
"type": "progene_text",
"text": [
"Telomerase RNA function in recombinant Tetrahymena telomerase ."
],
"offsets": [
[
0,
63
]
]
}
]
| [
{
"id": "split_0_train_5987_entity",
"type": "progene_text",
"text": [
"Telomerase"
],
"offsets": [
[
0,
10
]
],
"normalized": []
},
{
"id": "split_0_train_5988_entity",
"type": "progene_text",
"text": [
"telomerase"
],
"offsets": [
[
51,
61
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3681 | split_0_train_3681 | [
{
"id": "split_0_train_3681_passage",
"type": "progene_text",
"text": [
"Telomerase is a ribonucleoprotein reverse transcriptase specialized for use of a sequence within its integral RNA component as the template for DNA synthesis ."
],
"offsets": [
[
0,
159
]
]
}
]
| [
{
"id": "split_0_train_5989_entity",
"type": "progene_text",
"text": [
"Telomerase"
],
"offsets": [
[
0,
10
]
],
"normalized": []
},
{
"id": "split_0_train_5990_entity",
"type": "progene_text",
"text": [
"reverse transcriptase"
],
"offsets": [
[
34,
55
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3682 | split_0_train_3682 | [
{
"id": "split_0_train_3682_passage",
"type": "progene_text",
"text": [
"Telomerase adds telomeric simple sequence repeats to single - stranded primers in vitro or chromosome ends in vivo ."
],
"offsets": [
[
0,
116
]
]
}
]
| [
{
"id": "split_0_train_5991_entity",
"type": "progene_text",
"text": [
"Telomerase"
],
"offsets": [
[
0,
10
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3683 | split_0_train_3683 | [
{
"id": "split_0_train_3683_passage",
"type": "progene_text",
"text": [
"We have investigated the sequences and structures of recombinant Tetrahymena thermophila telomerase RNA necessary for physical association and activity with the catalytic protein subunit expressed in rabbit reticulocyte lysate ."
],
"offsets": [
[
0,
228
]
]
}
]
| [
{
"id": "split_0_train_5992_entity",
"type": "progene_text",
"text": [
"telomerase"
],
"offsets": [
[
89,
99
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3684 | split_0_train_3684 | [
{
"id": "split_0_train_3684_passage",
"type": "progene_text",
"text": [
"In contrast with previous results using another reconstitution method , we find that phylogenetically conserved primary sequences and a phylogenetically nonconserved secondary structure are essential for telomerase RNA function ."
],
"offsets": [
[
0,
229
]
]
}
]
| [
{
"id": "split_0_train_5993_entity",
"type": "progene_text",
"text": [
"telomerase"
],
"offsets": [
[
204,
214
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3685 | split_0_train_3685 | [
{
"id": "split_0_train_3685_passage",
"type": "progene_text",
"text": [
"Telomerase RNA binding to the catalytic protein subunit requires sequences 5' of the template and is highly sequence specific ."
],
"offsets": [
[
0,
127
]
]
}
]
| [
{
"id": "split_0_train_5994_entity",
"type": "progene_text",
"text": [
"Telomerase"
],
"offsets": [
[
0,
10
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3686 | split_0_train_3686 | [
{
"id": "split_0_train_3686_passage",
"type": "progene_text",
"text": [
"Other telomerase RNA sequences are required for enzyme activity and proper template use but not for protein interaction affinity ."
],
"offsets": [
[
0,
130
]
]
}
]
| [
{
"id": "split_0_train_5995_entity",
"type": "progene_text",
"text": [
"telomerase"
],
"offsets": [
[
6,
16
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3687 | split_0_train_3687 | [
{
"id": "split_0_train_3687_passage",
"type": "progene_text",
"text": [
"In addition , we demonstrate that the production of active recombinant telomerase requires a factor in rabbit reticulocyte lysate that promotes ribonucleoprotein assembly ."
],
"offsets": [
[
0,
172
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3688 | split_0_train_3688 | [
{
"id": "split_0_train_3688_passage",
"type": "progene_text",
"text": [
"These studies demonstrate multiple functions for the telomerase RNA and indicate that recombinant telomerase activity requires more than the catalytic protein and RNA components of the enzyme that have been identified to date ."
],
"offsets": [
[
0,
227
]
]
}
]
| [
{
"id": "split_0_train_5996_entity",
"type": "progene_text",
"text": [
"telomerase"
],
"offsets": [
[
53,
63
]
],
"normalized": []
},
{
"id": "split_0_train_5997_entity",
"type": "progene_text",
"text": [
"telomerase"
],
"offsets": [
[
98,
108
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3689 | split_0_train_3689 | [
{
"id": "split_0_train_3689_passage",
"type": "progene_text",
"text": [
"Multiple mitochondrial viruses in an isolate of the Dutch Elm disease fungus Ophiostoma novo - ulmi ."
],
"offsets": [
[
0,
101
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3690 | split_0_train_3690 | [
{
"id": "split_0_train_3690_passage",
"type": "progene_text",
"text": [
"The nucleotide sequences of three mitochondrial virus double - stranded ( ds ) RNAs , RNA - 4 ( 2599 nucleotides ) , RNA-5 ( 2474 nucleotides ) , and RNA-6 ( 2343 nucleotides ) , in a diseased isolate Log1 / 3-8d2 ( Ld ) of the Dutch elm disease fungus Ophiostoma novo - ulmi have been determined ."
],
"offsets": [
[
0,
298
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3691 | split_0_train_3691 | [
{
"id": "split_0_train_3691_passage",
"type": "progene_text",
"text": [
"All these RNAs are A - U - rich ( 71 - 73 % A + U residues ) ."
],
"offsets": [
[
0,
62
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3692 | split_0_train_3692 | [
{
"id": "split_0_train_3692_passage",
"type": "progene_text",
"text": [
"Using the fungal mitochondrial genetic code in which UGA codes for tryptophan , the positive - strand of each of RNAs 4 , 5 , and 6 contains a single open reading frame ( ORF ) with the potential to encode a protein of 783 , 729 , and 695 amino acids , respectively , all of which contain conserved motifs characteristic of RNA - dependent RNA polymerases ( RdRps ) ."
],
"offsets": [
[
0,
367
]
]
}
]
| [
{
"id": "split_0_train_5998_entity",
"type": "progene_text",
"text": [
"RNA - dependent RNA polymerases"
],
"offsets": [
[
324,
355
]
],
"normalized": []
},
{
"id": "split_0_train_5999_entity",
"type": "progene_text",
"text": [
"RdRps"
],
"offsets": [
[
358,
363
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3693 | split_0_train_3693 | [
{
"id": "split_0_train_3693_passage",
"type": "progene_text",
"text": [
"Sequence comparisons showed that these RNAs are related to each other and to a previously characterized RNA , RNA - 3a , from the same O. novo - ulmi isolate , especially within the RdRp - like motifs ."
],
"offsets": [
[
0,
202
]
]
}
]
| [
{
"id": "split_0_train_6000_entity",
"type": "progene_text",
"text": [
"RdRp"
],
"offsets": [
[
182,
186
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3694 | split_0_train_3694 | [
{
"id": "split_0_train_3694_passage",
"type": "progene_text",
"text": [
"However , the overall RNA nucleotide and RdRp amino acid sequence identities were relatively low ( 43 - 55 % and 20 - 32 % , respectively ) ."
],
"offsets": [
[
0,
141
]
]
}
]
| [
{
"id": "split_0_train_6001_entity",
"type": "progene_text",
"text": [
"RdRp"
],
"offsets": [
[
41,
45
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3695 | split_0_train_3695 | [
{
"id": "split_0_train_3695_passage",
"type": "progene_text",
"text": [
"The 5' - and 3' - terminal sequences of these RNAs are different , but they can all be folded into potentially stable stem - loop structures ."
],
"offsets": [
[
0,
142
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3696 | split_0_train_3696 | [
{
"id": "split_0_train_3696_passage",
"type": "progene_text",
"text": [
"Those of RNA-4 and RNA-6 have inverted complementarity , potentially forming panhandle structures ."
],
"offsets": [
[
0,
99
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3697 | split_0_train_3697 | [
{
"id": "split_0_train_3697_passage",
"type": "progene_text",
"text": [
"Their molecular and biological properties indicate that RNAs 3a , 4 , 5 , and 6 are the genomes of four different viruses , which replicate independently in the same cell ."
],
"offsets": [
[
0,
172
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3698 | split_0_train_3698 | [
{
"id": "split_0_train_3698_passage",
"type": "progene_text",
"text": [
"These four viruses are also related to a mitochondrial RNA virus from another fungus , Cryphonectria parasitica , recently designated the type species of the Mitovirus genus of the Narnaviridae family , and to a virus from the fungus Rhizoctonia solani ."
],
"offsets": [
[
0,
254
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3699 | split_0_train_3699 | [
{
"id": "split_0_train_3699_passage",
"type": "progene_text",
"text": [
"It is proposed that the four O. novo - ulmi mitochondrial viruses are assigned to the Mitovirus genus and designated O. novo - ulmi mitovirus ( OnuMV ) 3a - Ld , 4 - Ld , 5 - Ld , and 6-Ld , respectively ."
],
"offsets": [
[
0,
205
]
]
}
]
| []
| []
| []
| []
|
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